| Year |
Citation |
Score |
| 2020 |
de Souza Neto LR, Moreira-Filho JT, Neves BJ, Maidana RLBR, Guimarães ACR, Furnham N, Andrade CH, Silva FP. Strategies to Support Fragment-to-Lead Optimization in Drug Discovery. Frontiers in Chemistry. 8: 93. PMID 32133344 DOI: 10.3389/Fchem.2020.00093 |
0.306 |
|
| 2019 |
Tyzack JD, Furnham N, Sillitoe I, Orengo CM, Thornton JM. Exploring Enzyme Evolution from Changes in Sequence, Structure, and Function. Methods in Molecular Biology (Clifton, N.J.). 1851: 263-275. PMID 30298402 DOI: 10.1007/978-1-4939-8736-8_14 |
0.602 |
|
| 2017 |
Valasatava Y, Rosato A, Furnham N, Thornton JM, Andreini C. To what extent do structural changes in catalytic metal sites affect enzyme function? Journal of Inorganic Biochemistry. 179: 40-53. PMID 29161638 DOI: 10.1016/J.Jinorgbio.2017.11.002 |
0.539 |
|
| 2017 |
Ribeiro AJM, Holliday GL, Furnham N, Tyzack JD, Ferris K, Thornton JM. Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites. Nucleic Acids Research. PMID 29106569 DOI: 10.1093/Nar/Gkx1012 |
0.551 |
|
| 2017 |
Tyzack JD, Furnham N, Sillitoe I, Orengo CM, Thornton JM. Understanding enzyme function evolution from a computational perspective. Current Opinion in Structural Biology. 47: 131-139. PMID 28892668 DOI: 10.1016/J.Sbi.2017.08.003 |
0.592 |
|
| 2017 |
Furnham N. Complementary Sources of Protein Functional Information: The Far Side of GO. Methods in Molecular Biology (Clifton, N.J.). 1446: 263-274. PMID 27812949 DOI: 10.1007/978-1-4939-3743-1_19 |
0.444 |
|
| 2016 |
Mascotti ML, Ayub MJ, Furnham N, Thornton JM, Laskowski RA. Chopping and changing: The evolution of the flavin-dependent monooxygenases. Journal of Molecular Biology. PMID 27423402 DOI: 10.1016/J.Jmb.2016.07.003 |
0.573 |
|
| 2016 |
Phelan J, Coll F, McNerney R, Ascher DB, Pires DE, Furnham N, Coeck N, Hill-Cawthorne GA, Nair MB, Mallard K, Ramsay A, Campino S, Hibberd ML, Pain A, Rigouts L, et al. Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance. Bmc Medicine. 14: 31. PMID 27005572 DOI: 10.1186/S12916-016-0575-9 |
0.342 |
|
| 2015 |
Sillitoe I, Furnham N. FunTree: advances in a resource for exploring and contextualising protein function evolution. Nucleic Acids Research. PMID 26590404 DOI: 10.1093/Nar/Gkv1274 |
0.544 |
|
| 2015 |
Furnham N, Dawson NL, Rahman SA, Thornton JM, Orengo CA. Large-Scale Analysis Exploring Evolution of Catalytic Machineries and Mechanisms in Enzyme Superfamilies. Journal of Molecular Biology. PMID 26585402 DOI: 10.1016/J.Jmb.2015.11.010 |
0.62 |
|
| 2015 |
Tyagi N, Farnell EJ, Fitzsimmons CM, Ryan S, Tukahebwa E, Maizels RM, Dunne DW, Thornton JM, Furnham N. Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity. Plos Computational Biology. 11: e1004546. PMID 26513360 DOI: 10.1371/Journal.Pcbi.1004546 |
0.473 |
|
| 2015 |
Martínez Cuesta S, Rahman SA, Furnham N, Thornton JM. The Classification and Evolution of Enzyme Function. Biophysical Journal. PMID 25986631 DOI: 10.1016/J.Bpj.2015.04.020 |
0.603 |
|
| 2015 |
Benavente ED, Coll F, Furnham N, McNerney R, Glynn JR, Campino S, Pain A, Mohareb FR, Clark TG. PhyTB: Phylogenetic tree visualisation and sample positioning for M. tuberculosis. Bmc Bioinformatics. 16: 155. PMID 25968323 DOI: 10.1186/S12859-015-0603-3 |
0.327 |
|
| 2015 |
Farnell EJ, Tyagi N, Ryan S, Chalmers IW, Pinot de Moira A, Jones FM, Wawrzyniak J, Fitzsimmons CM, Tukahebwa EM, Furnham N, Maizels RM, Dunne DW. Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection. Frontiers in Immunology. 6: 26. PMID 25691884 DOI: 10.3389/Fimmu.2015.00026 |
0.323 |
|
| 2015 |
Sillitoe I, Lewis TE, Cuff A, Das S, Ashford P, Dawson NL, Furnham N, Laskowski RA, Lee D, Lees JG, Lehtinen S, Studer RA, Thornton J, Orengo CA. CATH: comprehensive structural and functional annotations for genome sequences. Nucleic Acids Research. 43: D376-81. PMID 25348408 DOI: 10.1093/Nar/Gku947 |
0.566 |
|
| 2014 |
Martinez Cuesta S, Furnham N, Rahman SA, Sillitoe I, Thornton JM. The evolution of enzyme function in the isomerases. Current Opinion in Structural Biology. 26: 121-30. PMID 25000289 DOI: 10.1016/J.Sbi.2014.06.002 |
0.606 |
|
| 2014 |
Holliday GL, Rahman SA, Furnham N, Thornton JM. Exploring the biological and chemical complexity of the ligases. Journal of Molecular Biology. 426: 2098-111. PMID 24657765 DOI: 10.1016/J.Jmb.2014.03.008 |
0.592 |
|
| 2014 |
Rahman SA, Cuesta SM, Furnham N, Holliday GL, Thornton JM. EC-BLAST: a tool to automatically search and compare enzyme reactions. Nature Methods. 11: 171-4. PMID 24412978 DOI: 10.1038/Nmeth.2803 |
0.546 |
|
| 2014 |
Furnham N, Holliday GL, de Beer TA, Jacobsen JO, Pearson WR, Thornton JM. The Catalytic Site Atlas 2.0: cataloging catalytic sites and residues identified in enzymes. Nucleic Acids Research. 42: D485-9. PMID 24319146 DOI: 10.1093/Nar/Gkt1243 |
0.602 |
|
| 2013 |
Sillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM, Orengo CA. New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. Nucleic Acids Research. 41: D490-8. PMID 23203873 DOI: 10.1093/Nar/Gks1211 |
0.591 |
|
| 2013 |
Furnham N, Laskowski RA, Thornton JM. Abstracting knowledge from the protein data bank. Biopolymers. 99: 183-8. PMID 23023892 DOI: 10.1002/Bip.22107 |
0.501 |
|
| 2012 |
Furnham N, de Beer TA, Thornton JM. Current challenges in genome annotation through structural biology and bioinformatics. Current Opinion in Structural Biology. 22: 594-601. PMID 22884875 DOI: 10.1016/J.Sbi.2012.07.005 |
0.556 |
|
| 2012 |
Furnham N, Sillitoe I, Holliday GL, Cuff AL, Laskowski RA, Orengo CA, Thornton JM. Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies. Plos Computational Biology. 8: e1002403. PMID 22396634 DOI: 10.1371/Journal.Pcbi.1002403 |
0.626 |
|
| 2012 |
Furnham N, Sillitoe I, Holliday GL, Cuff AL, Rahman SA, Laskowski RA, Orengo CA, Thornton JM. FunTree: a resource for exploring the functional evolution of structurally defined enzyme superfamilies. Nucleic Acids Research. 40: D776-82. PMID 22006843 DOI: 10.1093/Nar/Gkr852 |
0.634 |
|
| 2012 |
Cuesta SM, Furnham N, Thornton JM. Evolution of NAD (P)H binding domain superfamily F1000research. 3. DOI: 10.7490/F1000Research.1089820.1 |
0.44 |
|
| 2011 |
Cuff AL, Sillitoe I, Lewis T, Clegg AB, Rentzsch R, Furnham N, Pellegrini-Calace M, Jones D, Thornton J, Orengo CA. Extending CATH: increasing coverage of the protein structure universe and linking structure with function. Nucleic Acids Research. 39: D420-6. PMID 21097779 DOI: 10.1093/Nar/Gkq1001 |
0.585 |
|
| 2009 |
Furnham N, Garavelli JS, Apweiler R, Thornton JM. Missing in action: enzyme functional annotations in biological databases. Nature Chemical Biology. 5: 521-5. PMID 19620987 DOI: 10.1038/Nchembio0809-521 |
0.585 |
|
| 2008 |
Ragone S, Maman JD, Furnham N, Pellegrini L. Structural basis for inhibition of homologous recombination by the RecX protein. The Embo Journal. 27: 2259-69. PMID 18650935 DOI: 10.1038/Emboj.2008.145 |
0.379 |
|
| 2008 |
Furnham N, de Bakker PI, Gore S, Burke DF, Blundell TL. Comparative modelling by restraint-based conformational sampling. Bmc Structural Biology. 8: 7. PMID 18237407 DOI: 10.1186/1472-6807-8-7 |
0.372 |
|
| 2006 |
Furnham N, Doré AS, Chirgadze DY, de Bakker PI, Depristo MA, Blundell TL. Knowledge-based real-space explorations for low-resolution structure determination. Structure (London, England : 1993). 14: 1313-20. PMID 16905105 DOI: 10.1016/J.Str.2006.06.014 |
0.354 |
|
| 2006 |
Doré AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL. Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. Dna Repair. 5: 362-8. PMID 16388993 DOI: 10.1016/J.Dnarep.2005.11.004 |
0.312 |
|
| 2004 |
Furnham N, Ruffle S, Southan C. Splice variants: a homology modeling approach. Proteins. 54: 596-608. PMID 14748006 DOI: 10.1002/Prot.10568 |
0.401 |
|
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