Tom Blundell - Publications

Biochemistry University of Cambridge, Cambridge, England, United Kingdom 
structural biology, structural bioinformatics

339 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Hnízda A, Tesina P, Nguyen TB, Kukačka Z, Kater L, Chaplin A, Beckmann R, Ascher DB, Novák P, Blundell TL. SAP domain forms a flexible part of DNA aperture in Ku70/80. The Febs Journal. PMID 33511782 DOI: 10.1111/febs.15732  0.44
2021 Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK. Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis. Structure (London, England : 1993). PMID 33444527 DOI: 10.1016/j.str.2020.12.008  0.4
2021 Mendes V, Green SR, Evans JC, Hess J, Blaszczyk M, Spry C, Bryant O, Cory-Wright J, Chan DS, Torres PHM, Wang Z, Nahiyaan N, O'Neill S, Damerow S, Post J, ... ... Blundell TL, et al. Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site. Nature Communications. 12: 143. PMID 33420031 DOI: 10.1038/s41467-020-20224-x  0.32
2021 Alsulami AF, Thomas SE, Jamasb AR, Beaudoin CA, Moghul I, Bannerman B, Copoiu L, Vedithi SC, Torres P, Blundell TL. SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets. Briefings in Bioinformatics. PMID 33416848 DOI: 10.1093/bib/bbaa404  0.44
2020 Vedithi SC, Malhotra S, Skwark MJ, Munir A, Acebrón-García-De-Eulate M, Waman VP, Alsulami A, Ascher DB, Blundell TL. HARP: a database of structural impacts of systematic missense mutations in drug targets of . Computational and Structural Biotechnology Journal. 18: 3692-3704. PMID 33304465 DOI: 10.1016/j.csbj.2020.11.013  0.44
2020 Munir A, Vedithi SC, Chaplin AK, Blundell TL. Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance. Frontiers in Genetics. 11: 965. PMID 33101362 DOI: 10.3389/fgene.2020.00965  0.4
2020 Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL. Dimers of DNA-PK create a stage for DNA double-strand break repair. Nature Structural & Molecular Biology. PMID 33077952 DOI: 10.1038/s41594-020-00517-x  0.4
2020 Maryam A, Khalid RR, Vedithi SC, Ece A, Çınaroğlu SS, Siddiqi AR, Blundell TL. Exploring the structural basis of conformational heterogeneity and autoinhibition of human cGMP-specific protein kinase Iα through computational modelling and molecular dynamics simulations. Computational and Structural Biotechnology Journal. 18: 1625-1638. PMID 32670503 DOI: 10.1016/j.csbj.2020.06.016  0.4
2020 Waman VP, Blundell TL, Buchan DWA, Gough J, Jones D, Kelley L, Murzin A, Pandurangan AP, Sillitoe I, Sternberg M, Torres P, Orengo C. The Genome3D Consortium for Structural Annotations of Selected Model Organisms. Methods in Molecular Biology (Clifton, N.J.). 2165: 27-67. PMID 32621218 DOI: 10.1007/978-1-0716-0708-4_3  0.84
2020 Thomas SE, Whitehouse AJ, Brown K, Burbaud S, Belardinelli JM, Sangen J, Lahiri R, Libardo MDJ, Gupta P, Malhotra S, Boshoff HIM, Jackson M, Abell C, Coyne AG, Blundell TL, et al. Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Research. PMID 32602532 DOI: 10.1093/nar/gkaa539  0.44
2020 Ochi T, Quarantotti V, Lin H, Jullien J, Rosa E Silva I, Boselli F, Barnabas DD, Johnson CM, McLaughlin SH, Freund SMV, Blackford AN, Kimata Y, Goldstein RE, Jackson SP, Blundell TL, et al. CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions. Structure (London, England : 1993). PMID 32375023 DOI: 10.1016/j.str.2020.04.010  0.48
2020 Vedithi SC, Rodrigues CHM, Portelli S, Skwark MJ, Das M, Ascher DB, Blundell TL, Malhotra S. Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in . Computational and Structural Biotechnology Journal. 18: 271-286. PMID 32042379 DOI: 10.1016/j.csbj.2020.01.002  0.44
2019 Homeyer N, van Deursen R, Ochoa-Montaño B, Heikamp K, Ray P, Zuccotto F, Blundell TL, Gilbert IH. A platform for target prediction of phenotypic screening hit molecules. Journal of Molecular Graphics & Modelling. 107485. PMID 31836397 DOI: 10.1016/j.jmgm.2019.107485  0.36
2019 Mendes V, Acebrón-García-de-Eulate M, Verma N, Blaszczyk M, Dias MVB, Blundell TL. Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate. Mbio. 10. PMID 31772052 DOI: 10.1128/mBio.02272-19  0.32
2019 Trapero A, Pacitto A, Chan DS, Abell C, Blundell TL, Ascher DB, Coyne AG. Covalent inactivation of Mycobacterium thermoresistibile inosine-5'-monophosphate dehydrogenase (IMPDH). Bioorganic & Medicinal Chemistry Letters. 126792. PMID 31757668 DOI: 10.1016/j.bmcl.2019.126792  0.44
2019 Sillitoe I, Andreeva A, Blundell TL, Buchan DWA, Finn RD, Gough J, Jones D, Kelley LA, Paysan-Lafosse T, Lam SD, Murzin AG, Pandurangan AP, Salazar GA, Skwark MJ, Sternberg MJE, et al. Genome3D: integrating a collaborative data pipeline to expand the depth and breadth of consensus protein structure annotation. Nucleic Acids Research. PMID 31733063 DOI: 10.1093/nar/gkz967  0.84
2019 Pandurangan AP, Blundell TL. Prediction of impacts of mutations on protein structure and interactions: SDM, a statistical approach, and mCSM, using machine learning. Protein Science : a Publication of the Protein Society. PMID 31693276 DOI: 10.1002/pro.3774  0.84
2019 Skwark MJ, Torres PHM, Copoiu L, Bannerman B, Floto RA, Blundell TL. Mabellini: a genome-wide database for understanding the structural proteome and evaluating prospective antimicrobial targets of the emerging pathogen Mycobacterium abscessus. Database : the Journal of Biological Databases and Curation. 2019. PMID 31681953 DOI: 10.1093/database/baz113  0.4
2019 Copoiu L, Torres PHM, Ascher DB, Blundell TL, Malhotra S. ProCarbDB: a database of carbohydrate-binding proteins. Nucleic Acids Research. PMID 31598690 DOI: 10.1093/nar/gkz860  0.44
2019 Saltzberg DJ, Hepburn M, Pilla KB, Schriemer DC, Lees-Miller SP, Blundell TL, Sali A. SSEThread: Integrative threading of the DNA-PKcs sequence based on data from chemical cross-linking and hydrogen deuterium exchange. Progress in Biophysics and Molecular Biology. PMID 31570166 DOI: 10.1016/j.pbiomolbio.2019.09.003  0.68
2019 Malhotra S, Alsulami AF, Heiyun Y, Ochoa BM, Jubb H, Forbes S, Blundell TL. Understanding the impacts of missense mutations on structures and functions of human cancer-related genes: A preliminary computational analysis of the COSMIC Cancer Gene Census. Plos One. 14: e0219935. PMID 31323058 DOI: 10.1371/journal.pone.0219935  0.4
2019 Munir A, Kumar N, Ramalingam SB, Tamilzhalagan S, Shanmugam SK, Palaniappan AN, Nair D, Priyadarshini P, Natarajan M, Tripathy S, Ranganathan UD, Peacock SJ, Parkhill J, Blundell TL, Malhotra S. Identification and Characterization of Genetic Determinants of Isoniazid and Rifampicin Resistance in Mycobacterium tuberculosis in Southern India. Scientific Reports. 9: 10283. PMID 31311987 DOI: 10.1038/s41598-019-46756-x  0.4
2019 Whitehouse A, Thomas SE, Brown KP, Fanourakis A, Chan D, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG. Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches. Journal of Medicinal Chemistry. PMID 31282680 DOI: 10.1021/acs.jmedchem.9b00809  0.44
2019 Singh V, Pacitto A, Donini S, Ferraris DM, Boros S, Illyés E, Szokol B, Rizzi M, Blundell TL, Ascher DB, Pato J, Mizrahi V. Synthesis and Structure-Activity relationship of 1-(5-isoquinolinesulfonyl)piperazine analogues as inhibitors of Mycobacterium tuberculosis IMPDH. European Journal of Medicinal Chemistry. 174: 309-329. PMID 31055147 DOI: 10.1016/j.ejmech.2019.04.027  0.44
2019 Thomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL. Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 377: 20180422. PMID 31030650 DOI: 10.1098/rsta.2018.0422  0.44
2019 Wu Q, Liang S, Ochi T, Chirgadze DY, Huiskonen JT, Blundell TL. Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways. Progress in Biophysics and Molecular Biology. PMID 31014919 DOI: 10.1016/j.pbiomolbio.2019.03.007  0.48
2019 Maryam A, Vedithi SC, Khalid RR, Alsulami AF, Torres PHM, Siddiqi AR, Blundell TL. The Molecular Organization of Human cGMP Specific Phosphodiesterase 6 (PDE6): Structural Implications of Somatic Mutations in Cancer and Retinitis Pigmentosa. Computational and Structural Biotechnology Journal. 17: 378-389. PMID 30962868 DOI: 10.1016/j.csbj.2019.03.004  0.4
2019 Waman VP, Vedithi SC, Thomas SE, Bannerman BP, Munir A, Skwark MJ, Malhotra S, Blundell TL. Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery. Emerging Microbes & Infections. 8: 109-118. PMID 30866765 DOI: 10.1080/22221751.2018.1561158  0.44
2018 Nishi R, Wijnhoven PWG, Kimura Y, Matsui M, Konietzny R, Wu Q, Nakamura K, Blundell TL, Kessler BM. The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage. Scientific Reports. 8: 17891. PMID 30559450 DOI: 10.1038/s41598-018-36235-0  0.4
2018 Tiwari S, van Tonder AJ, Vilchèze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR. Arginine-deprivation-induced oxidative damage sterilizes . Proceedings of the National Academy of Sciences of the United States of America. PMID 30143580 DOI: 10.1073/pnas.1808874115  0.44
2018 Roca C, Requena C, Sebastián-Pérez V, Malhotra S, Radoux C, Pérez C, Martinez A, Antonio Páez J, Blundell TL, Campillo NE. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of Enzyme Inhibition and Medicinal Chemistry. 33: 1034-1047. PMID 29873262 DOI: 10.1080/14756366.2018.1476502  0.4
2018 Vedithi SC, Malhotra S, Das M, Daniel S, Kishore N, George A, Arumugam S, Rajan L, Ebenezer M, Ascher DB, Arnold E, Blundell TL. Publisher Correction: Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae. Scientific Reports. 8: 8250. PMID 29789675 DOI: 10.1038/s41598-018-26451-z  0.44
2018 Wang JL, Duboc C, Wu Q, Ochi T, Liang S, Tsutakawa SE, Lees-Miller SP, Nadal M, Tainer JA, Blundell TL, Strick TR. Dissection of DNA double-strand-break repair using novel single-molecule forceps. Nature Structural & Molecular Biology. PMID 29786079 DOI: 10.1038/s41594-018-0065-1  0.48
2018 Vedithi SC, Malhotra S, Das M, Daniel S, Kishore N, George A, Arumugam S, Rajan L, Ebenezer M, Ascher DB, Arnold E, Blundell TL. Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae. Scientific Reports. 8: 5016. PMID 29567948 DOI: 10.1038/s41598-018-23423-1  0.44
2018 Trapero A, Pacitto A, Singh V, Sabbah M, Coyne AG, Mizrahi V, Blundell TL, Ascher DB, Abell C. A fragment-based approach to targeting inosine-5´-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis. Journal of Medicinal Chemistry. PMID 29547284 DOI: 10.1021/acs.jmedchem.7b01622  0.44
2017 Malhotra S, Mugumbate G, Blundell TL, Higueruelo AP. TIBLE: a web-based, freely accessible resource for small-molecule binding data for mycobacterial species. Database : the Journal of Biological Databases and Curation. 2017. PMID 29220433 DOI: 10.1093/database/bax041  0.4
2017 Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP. Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach. Frontiers in Pharmacology. 8: 681. PMID 29018348 DOI: 10.3389/fphar.2017.00681  0.52
2017 Malhotra S, Vedithi SC, Blundell TL. Decoding the similarities and differences among mycobacterial species. Plos Neglected Tropical Diseases. 11: e0005883. PMID 28854187 DOI: 10.1371/journal.pntd.0005883  0.4
2017 Arora K, Ochoa-Montaño B, Tsang PS, Blundell TL, Dawes SS, Mizrahi V, Bayliss T, Mackenzie CJ, Cleghorn LAT, Ray PC, Wyatt PG, Uh E, Lee J, Barry CE, Boshoff HI. Correction for Arora et al., "Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis". Antimicrobial Agents and Chemotherapy. 61. PMID 28839085 DOI: 10.1128/AAC.01429-17  0.36
2017 Chirgadze DY, Ascher DB, Blundell TL, Sibanda BL. DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage. Methods in Enzymology. 592: 145-157. PMID 28668119 DOI: 10.1016/bs.mie.2017.04.001  0.52
2017 Thomas SE, Mendes V, Kim SY, Malhotra S, Ochoa-Montaño B, Blaszczyk M, Blundell TL. Structural biology and the design of new therapeutics: from HIV and cancer to mycobacterial infections. Journal of Molecular Biology. PMID 28648615 DOI: 10.1016/j.jmb.2017.06.014  0.44
2017 Pandurangan AP, Ochoa-Montaño B, Ascher DB, Blundell TL. SDM: a server for predicting effects of mutations on protein stability. Nucleic Acids Research. PMID 28525590 DOI: 10.1093/nar/gkx439  0.84
2017 Chan DS, Mendes V, Thomas SE, McConnell BN, Matak-Vinković D, Coyne AG, Blundell TL, Abell C. Fragment screening against the EthR-DNA interaction by native mass spectrometry. Angewandte Chemie (International Ed. in English). PMID 28513917 DOI: 10.1002/anie.201702888  0.44
2017 Ochoa-Montaño B, Blundell TL. XSuLT: a web server for structural annotation and representation of sequence-structure alignments. Nucleic Acids Research. PMID 28510698 DOI: 10.1093/nar/gkx421  0.36
2017 Pandurangan AP, Ascher DB, Thomas SE, Blundell TL. Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance. Biochemical Society Transactions. 45: 303-311. PMID 28408471 DOI: 10.1042/BST20160422  0.84
2017 Shiu-Hin Chan D, Seetoh WG, McConnell BN, Matak-Vinković D, Thomas SE, Mendes V, Blaszczyk M, Coyne AG, Blundell TL, Abell C. Structural insights into the EthR-DNA interaction using native mass spectrometry. Chemical Communications (Cambridge, England). PMID 28287239 DOI: 10.1039/c7cc00804j  0.44
2017 Sibanda BL, Chirgadze DY, Ascher DB, Blundell TL. DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair. Science (New York, N.Y.). 355: 520-524. PMID 28154079 DOI: 10.1126/science.aak9654  0.52
2016 Malhotra S, Thomas SE, Ochoa Montano B, Blundell TL. Structure-guided, target-based drug discovery - exploiting genome information from HIV to mycobacterial infections. Postepy Biochemii. 62: 262-272. PMID 28132480  0.44
2016 Jubb HC, Higueruelo AP, Ochoa-Montaño B, Pitt WR, Ascher DB, Blundell TL. Arpeggio: A web server for calculating and visualising interatomic interactions in protein structures. Journal of Molecular Biology. PMID 27964945 DOI: 10.1016/j.jmb.2016.12.004  0.44
2016 Jubb HC, Pandurangan AP, Turner MA, Ochoa-Montaño B, Blundell TL, Ascher DB. Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health. Progress in Biophysics and Molecular Biology. PMID 27913149 DOI: 10.1016/j.pbiomolbio.2016.10.002  0.84
2016 Singh V, Donini S, Pacitto A, Sala C, Hartkoorn RC, Dhar N, Keri G, Ascher DB, Mondésert G, Vocat A, Lupien A, Sommer R, Vermet H, Lagrange S, Buechler J, ... ... Blundell TL, et al. The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis. Acs Infectious Diseases. PMID 27726334 DOI: 10.1021/acsinfecdis.6b00102  0.44
2016 Park Y, Pacitto A, Bayliss T, Cleghorn LA, Wang Z, Hartman T, Arora K, Ioerger TR, Sacchettini J, Rizzi M, Donini S, Blundell TL, Ascher DB, Rhee KY, Breda A, et al. Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 27704782 DOI: 10.1021/acsinfecdis.6b00103  0.44
2016 Chang HH, Watanabe G, Gerodimos CA, Ochi T, Blundell TL, Jackson SP, Lieber MR. Different DNA End Configurations Dictate Which NHEJ Components are Most Important for Joining Efficiency. The Journal of Biological Chemistry. PMID 27703001 DOI: 10.1074/jbc.M116.752329  0.48
2016 Pires DE, Blundell TL, Ascher DB. mCSM-lig: quantifying the effects of mutations on protein-small molecule affinity in genetic disease and emergence of drug resistance. Scientific Reports. 6: 29575. PMID 27384129 DOI: 10.1038/srep29575  0.44
2016 Scott DE, Marsh M, Blundell TL, Abell C, Hyvönen M. Structure Activity Relationship of the Peptide Binding Motif Mediating the RAD51:BRCA2 Protein-Protein Interaction. Febs Letters. PMID 26992456 DOI: 10.1002/1873-3468.12139  1
2016 Pires DE, Chen J, Blundell TL, Ascher DB. In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity. Scientific Reports. 6: 19848. PMID 26797105 DOI: 10.1038/srep19848  0.44
2016 Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blundell TL. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Molecular Cell. PMID 26778126 DOI: 10.1016/j.molcel.2015.12.017  1
2015 Winter A, Sigurdardottir AG, DiCara D, Valenti G, Blundell TL, Gherardi E. Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach. Molecular Cancer Therapeutics. PMID 26712116 DOI: 10.1158/1535-7163.MCT-15-0446  1
2015 Pacitto A, Ascher DB, Wong LH, Blaszczyk BK, Nookala RK, Zhang N, Dokudovskaya S, Levine TP, Blundell TL. Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein. Open Biology. 5. PMID 26631379 DOI: 10.1098/rsob.150174  0.44
2015 Mendes V, Blaszczyk M, Maranha A, Empadinhas N, Blundell TL. Structure of Mycobacterium thermoresistibile GlgE defines novel conformational states that contribute to the catalytic mechanism. Scientific Reports. 5: 17144. PMID 26616850 DOI: 10.1038/srep17144  1
2015 Metri R, Hariharaputran S, Ramakrishnan G, Anand P, Raghavender US, Ochoa-Montaño B, Higueruelo AP, Sowdhamini R, Chandra NR, Blundell TL, Srinivasan N. SInCRe-structural interactome computational resource for Mycobacterium tuberculosis. Database : the Journal of Biological Databases and Curation. 2015. PMID 26130660 DOI: 10.1093/database/bav060  1
2015 Blaszczyk M, Harmer NJ, Chirgadze DY, Ascher DB, Blundell TL. Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors. Progress in Biophysics and Molecular Biology. PMID 25957048 DOI: 10.1016/j.pbiomolbio.2015.04.007  1
2015 Jafri M, Wake NC, Ascher DB, Pires DE, Gentle D, Morris MR, Rattenberry E, Simpson MA, Trembath RC, Weber A, Woodward ER, Donaldson A, Blundell TL, Latif F, Maher ER. Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma. Cancer Discovery. 5: 723-9. PMID 25873077 DOI: 10.1158/2159-8290.CD-14-1096  1
2015 Pires DE, Blundell TL, Ascher DB. pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures. Journal of Medicinal Chemistry. 58: 4066-72. PMID 25860834 DOI: 10.1021/acs.jmedchem.5b00104  0.44
2015 Ochoa-Montaño B, Mohan N, Blundell TL. CHOPIN: a web resource for the structural and functional proteome of Mycobacterium tuberculosis. Database : the Journal of Biological Databases and Curation. 2015. PMID 25833954 DOI: 10.1093/database/bav026  1
2015 Nemethova M, Radvanszky J, Kadasi L, Ascher DB, Pires DE, Blundell TL, Porfirio B, Mannoni A, Santucci A, Milucci L, Sestini S, Biolcati G, Sorge F, Aurizi C, Aquaron R, et al. Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy. European Journal of Human Genetics : Ejhg. PMID 25804398 DOI: 10.1038/ejhg.2015.60  1
2015 Murray JE, van der Burg M, IJspeert H, Carroll P, Wu Q, Ochi T, Leitch A, Miller ES, Kysela B, Jawad A, Bottani A, Brancati F, Cappa M, Cormier-Daire V, Deshpande C, ... ... Blundell TL, et al. Mutations in the NHEJ component XRCC4 cause primordial dwarfism. American Journal of Human Genetics. 96: 412-24. PMID 25728776 DOI: 10.1016/j.ajhg.2015.01.013  1
2015 Wu Q, Jubb H, Blundell TL. Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif. Progress in Biophysics and Molecular Biology. 117: 143-8. PMID 25701377 DOI: 10.1016/j.pbiomolbio.2015.02.003  1
2015 Usher JL, Ascher DB, Pires DE, Milan AM, Blundell TL, Ranganath LR. Analysis of HGD Gene Mutations in Patients with Alkaptonuria from the United Kingdom: Identification of Novel Mutations. Jimd Reports. PMID 25681086 DOI: 10.1007/8904_2014_380  0.44
2015 Jubb H, Blundell TL, Ascher DB. Flexibility and small pockets at protein-protein interfaces: New insights into druggability. Progress in Biophysics and Molecular Biology. PMID 25662442 DOI: 10.1016/j.pbiomolbio.2015.01.009  1
2015 Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP. DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair. Science (New York, N.Y.). 347: 185-8. PMID 25574025 DOI: 10.1126/science.1261971  1
2015 Ramakrishnan G, Ochoa-Montaño B, Raghavender US, Mudgal R, Joshi AG, Chandra NR, Sowdhamini R, Blundell TL, Srinivasan N. Enriching the annotation of Mycobacterium tuberculosis H37Rv proteome using remote homology detection approaches: insights into structure and function. Tuberculosis (Edinburgh, Scotland). 95: 14-25. PMID 25467293 DOI: 10.1016/  1
2015 Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cozzetto D, Dana JM, Filippis I, Gough J, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, Mistry J, et al. Genome3D: exploiting structure to help users understand their sequences. Nucleic Acids Research. 43: D382-6. PMID 25348407 DOI: 10.1093/nar/gku973  1
2015 Pires DE, Blundell TL, Ascher DB. Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes. Nucleic Acids Research. 43: D387-91. PMID 25324307 DOI: 10.1093/nar/gku966  0.44
2015 Sigurdardottir AG, Winter A, Sobkowicz A, Fragai M, Chirgadze D, Ascher DB, Blundell TL, Gherardi E. Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding Chemical Science. 6: 6147-6157. DOI: 10.1039/c5sc02155c  1
2015 Ascher DB, Jubb HC, Pires DEV, Ochi T, Higueruelo A, Blundell TL. Protein-protein interactions: Structures and druggability Nato Science For Peace and Security Series a: Chemistry and Biology. 38: 141-163. DOI: 10.1007/978-94-017-9719-1_12  1
2015 Blundell TL, Bolanos-Garcia V, Chirgadze DY, Harmer NJ, Lo T, Pellegrini L, Lynn Sibanda B. Asymmetry in the multiprotein systems of molecular biology Science of Crystal Structures: Highlights in Crystallography. 231-237. DOI: 10.1007/978-3-319-19827-9_24  1
2014 Hepburn L, Prajsnar TK, Klapholz C, Moreno P, Loynes CA, Ogryzko NV, Brown K, Schiebler M, Hegyi K, Antrobus R, Hammond KL, Connolly J, Ochoa B, Bryant C, Otto M, ... ... Blundell T, et al. Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus. Science (New York, N.Y.). 346: 641-6. PMID 25359976 DOI: 10.1126/science.1258705  0.32
2014 Pitt WR, Montalvão RW, Blundell TL. Polyphony: superposition independent methods for ensemble-based drug discovery. Bmc Bioinformatics. 15: 324. PMID 25265915 DOI: 10.1186/1471-2105-15-324  1
2014 Arora K, Ochoa-Montaño B, Tsang PS, Blundell TL, Dawes SS, Mizrahi V, Bayliss T, Mackenzie CJ, Cleghorn LA, Ray PC, Wyatt PG, Uh E, Lee J, Barry CE, Boshoff HI. Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 58: 6962-5. PMID 25155596 DOI: 10.1128/AAC.03486-14  1
2014 Mageed SN, Cunningham F, Hung AW, Silvestre HL, Wen S, Blundell TL, Abell C, McConkey GA. Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy. Antimicrobial Agents and Chemotherapy. 58: 6345-53. PMID 25049241 DOI: 10.1128/AAC.02640-14  1
2014 Pires DE, Ascher DB, Blundell TL. DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach. Nucleic Acids Research. 42: W314-9. PMID 24829462 DOI: 10.1093/nar/gku411  1
2014 Webb ME, Yorke BA, Kershaw T, Lovelock S, Lobley CM, Kilkenny ML, Smith AG, Blundell TL, Pearson AR, Abell C. Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase. Acta Crystallographica. Section D, Biological Crystallography. 70: 1166-72. PMID 24699660 DOI: 10.1107/S1399004713034275  1
2014 Brown A, Adam LE, Blundell TL. The crystal structure of fibroblast growth factor 18 (FGF18). Protein & Cell. 5: 343-7. PMID 24668462 DOI: 10.1007/s13238-014-0033-4  1
2014 Ochi T, Wu Q, Blundell TL. The spatial organization of non-homologous end joining: from bridging to end joining. Dna Repair. 17: 98-109. PMID 24636752 DOI: 10.1016/j.dnarep.2014.02.010  1
2014 Ballester PJ, Schreyer A, Blundell TL. Does a more precise chemical description of protein-ligand complexes lead to more accurate prediction of binding affinity? Journal of Chemical Information and Modeling. 54: 944-55. PMID 24528282 DOI: 10.1021/ci500091r  1
2014 Surade S, Ty N, Hengrung N, Lechartier B, Cole ST, Abell C, Blundell TL. A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR. The Biochemical Journal. 458: 387-94. PMID 24313835 DOI: 10.1042/BJ20131127  1
2014 Pires DE, Ascher DB, Blundell TL. mCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics (Oxford, England). 30: 335-42. PMID 24281696 DOI: 10.1093/bioinformatics/btt691  1
2014 Dias MV, Tyrakis P, Domingues RR, Paes Leme AF, Blundell TL. Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs. Structure (London, England : 1993). 22: 94-103. PMID 24210757 DOI: 10.1016/j.str.2013.09.022  1
2013 Tófoli de Araújo F, Bolanos-Garcia VM, Pereira CT, Sanches M, Oshiro EE, Ferreira RC, Chigardze DY, Barbosa JA, de Souza Ferreira LC, Benedetti CE, Blundell TL, Balan A. Structural and physiological analyses of the alkanesulphonate-binding protein (SsuA) of the citrus pathogen Xanthomonas citri. Plos One. 8: e80083. PMID 24282519 DOI: 10.1371/journal.pone.0080083  1
2013 Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proceedings of the National Academy of Sciences of the United States of America. 110: 12984-9. PMID 23872845 DOI: 10.1073/pnas.1304045110  1
2013 Schreyer AM, Blundell TL. CREDO: a structural interactomics database for drug discovery. Database : the Journal of Biological Databases and Curation. 2013: bat049. PMID 23868908 DOI: 10.1093/database/bat049  1
2013 Arendse L, Blundell TL, Blackburn J. Combining in silico protein stability calculations with structure-function relationships to explore the effect of polymorphic variation on cytochrome P450 drug metabolism. Current Drug Metabolism. 14: 745-63. PMID 23826828 DOI: 10.2174/13892002113149990097  1
2013 Higueruelo AP, Jubb H, Blundell TL. TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions. Database : the Journal of Biological Databases and Curation. 2013: bat039. PMID 23766369 DOI: 10.1093/database/bat039  1
2013 Higueruelo AP, Jubb H, Blundell TL. Protein-protein interactions as druggable targets: recent technological advances. Current Opinion in Pharmacology. 13: 791-6. PMID 23735579 DOI: 10.1016/j.coph.2013.05.009  1
2013 Brown A, Robinson CJ, Gallagher JT, Blundell TL. Cooperative heparin-mediated oligomerization of fibroblast growth factor-1 (FGF1) precedes recruitment of FGFR2 to ternary complexes. Biophysical Journal. 104: 1720-30. PMID 23601319 DOI: 10.1016/j.bpj.2013.02.051  1
2013 Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault JP, Lassalle G, ... Blundell TL, et al. Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell. 23: 489-501. PMID 23597563 DOI: 10.1016/j.ccr.2013.02.018  1
2013 Ochi T, Gu X, Blundell TL. Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair. Structure (London, England : 1993). 21: 672-9. PMID 23523427 DOI: 10.1016/j.str.2013.02.014  1
2013 Scott DE, Ehebauer MT, Pukala T, Marsh M, Blundell TL, Venkitaraman AR, Abell C, Hyvönen M. Using a fragment-based approach to target protein-protein interactions. Chembiochem : a European Journal of Chemical Biology. 14: 332-42. PMID 23344974 DOI: 10.1002/cbic.201200521  1
2013 Lewis TE, Sillitoe I, Andreeva A, Blundell TL, Buchan DW, Chothia C, Cuff A, Dana JM, Filippis I, Gough J, Hunter S, Jones DT, Kelley LA, Kleywegt GJ, Minneci F, et al. Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains. Nucleic Acids Research. 41: D499-507. PMID 23203986 DOI: 10.1093/nar/gks1266  1
2013 Schmidt MF, Korb O, Howard NI, Dias MV, Blundell TL, Abell C. Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach. Chemmedchem. 8: 54-8. PMID 23169689 DOI: 10.1002/cmdc.201200508  1
2012 Higueruelo AP, Schreyer A, Bickerton GR, Blundell TL, Pitt WR. What can we learn from the evolution of protein-ligand interactions to aid the design of new therapeutics? Plos One. 7: e51742. PMID 23240060 DOI: 10.1371/journal.pone.0051742  1
2012 Schreyer AM, Blundell T. USRCAT: real-time ultrafast shape recognition with pharmacophoric constraints. Journal of Cheminformatics. 4: 27. PMID 23131020 DOI: 10.1186/1758-2946-4-27  1
2012 Blundell TL. Professor Dame Louise Napier Johnson (26 September 1940-25 September 2012). Acta Crystallographica. Section D, Biological Crystallography. 68: 1588-90. PMID 23090409 DOI: 10.1107/S0907444912042965  1
2012 Thebault P, Chirgadze DY, Dou Z, Blundell TL, Elowe S, Bolanos-Garcia VM. Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint). The Biochemical Journal. 448: 321-8. PMID 23067341 DOI: 10.1042/BJ20121448  1
2012 Nookala RK, Langemeyer L, Pacitto A, Ochoa-Montaño B, Donaldson JC, Blaszczyk BK, Chirgadze DY, Barr FA, Bazan JF, Blundell TL. Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biology. 2: 120071. PMID 22977732 DOI: 10.1098/rsob.120071  1
2012 Winter A, Higueruelo AP, Marsh M, Sigurdardottir A, Pitt WR, Blundell TL. Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery. Quarterly Reviews of Biophysics. 45: 383-426. PMID 22971516 DOI: 10.1017/S0033583512000108  1
2012 Bolanos-Garcia VM, Nilsson J, Blundell TL. The architecture of the BubR1 tetratricopeptide tandem repeat defines a protein motif underlying mitotic checkpoint-kinetochore communication. Bioarchitecture. 2: 23-27. PMID 22754625  0.4
2012 Ochi T, Wu Q, Chirgadze DY, Grossmann JG, Bolanos-Garcia VM, Blundell TL. Structural insights into the role of domain flexibility in human DNA ligase IV. Structure (London, England : 1993). 20: 1212-22. PMID 22658747 DOI: 10.1016/j.str.2012.04.012  1
2012 Bolanos-Garcia VM, Wu Q, Ochi T, Chirgadze DY, Sibanda BL, Blundell TL. Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 370: 3023-39. PMID 22615474 DOI: 10.1098/rsta.2011.0268  1
2012 Bailey D, Carpenter EP, Coker A, Coker S, Read J, Jones AT, Erskine P, Aguilar CF, Badasso M, Toldo L, Rippmann F, Sanz-Aparicio J, Albert A, Blundell TL, Roberts NB, et al. An analysis of subdomain orientation, conformational change and disorder in relation to crystal packing of aspartic proteinases. Acta Crystallographica. Section D, Biological Crystallography. 68: 541-52. PMID 22525752 DOI: 10.1107/S0907444912004817  1
2012 Webb ME, Lobley CM, Soliman F, Kilkenny ML, Smith AG, Blundell TL, Abell C. Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 414-7. PMID 22505409 DOI: 10.1107/S1744309112009487  1
2012 Jubb H, Higueruelo AP, Winter A, Blundell TL. Structural biology and drug discovery for protein-protein interactions. Trends in Pharmacological Sciences. 33: 241-8. PMID 22503442 DOI: 10.1016/  1
2012 Surade S, Blundell TL. Structural biology and drug discovery of difficult targets: the limits of ligandability. Chemistry & Biology. 19: 42-50. PMID 22284353 DOI: 10.1016/j.chembiol.2011.12.013  1
2012 Lee S, Thebault P, Freschi L, Beaufils S, Blundell TL, Landry CR, Bolanos-Garcia VM, Elowe S. Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases. The Journal of Biological Chemistry. 287: 5988-6001. PMID 22187426 DOI: 10.1074/jbc.M111.307355  1
2012 Wu Q, Sibanda L, Ochi T, Bolanos-Garcia VM, Blundell TL, Chirgadze DY. Spatial and temporal organisation of multiprotein systems of cell regulation and signalling: What can we learn from NHEJ system of double-strand break repair? Nato Science For Peace and Security Series a: Chemistry and Biology. 1-31. DOI: 10.1007/978-94-007-2530-0_1  1
2011 Noble D. Editorial. Interface Focus. 1: 1-2. PMID 22419969 DOI: 10.1098/rsfs.2010.0385  1
2011 Bolanos-Garcia VM, Lischetti T, Matak-Vinković D, Cota E, Simpson PJ, Chirgadze DY, Spring DR, Robinson CV, Nilsson J, Blundell TL. Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site. Structure (London, England : 1993). 19: 1691-700. PMID 22000412 DOI: 10.1016/j.str.2011.09.017  1
2011 Wu Q, Ochi T, Matak-Vinkovic D, Robinson CV, Chirgadze DY, Blundell TL. Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions. Biochemical Society Transactions. 39: 1387-92, suppl 2 p f. PMID 21936820 DOI: 10.1042/BST0391387  1
2011 Abdel-Rahman N, Martinez-Arias A, Blundell TL. Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach. Biochemical Society Transactions. 39: 1327-33. PMID 21936810 DOI: 10.1042/BST0391327  1
2011 Bickerton GR, Higueruelo AP, Blundell TL. Comprehensive, atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database. Bmc Bioinformatics. 12: 313. PMID 21801404 DOI: 10.1186/1471-2105-12-313  1
2011 Blundell TL, Hendrickson WA. What is 'current opinion' in structural biology? Current Opinion in Structural Biology. 21: 447-9. PMID 21795039 DOI: 10.1016/  1
2011 Worth CL, Preissner R, Blundell TL. SDM--a server for predicting effects of mutations on protein stability and malfunction. Nucleic Acids Research. 39: W215-22. PMID 21593128 DOI: 10.1093/nar/gkr363  1
2011 Dias MV, Snee WC, Bromfield KM, Payne RJ, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. The Biochemical Journal. 436: 729-39. PMID 21410435 DOI: 10.1042/BJ20110002  1
2011 Gong S, Worth CL, Cheng TM, Blundell TL. Meet me halfway: when genomics meets structural bioinformatics. Journal of Cardiovascular Translational Research. 4: 281-303. PMID 21350909 DOI: 10.1007/s12265-011-9259-1  1
2011 Bolanos-Garcia VM, Blundell TL. BUB1 and BUBR1: multifaceted kinases of the cell cycle. Trends in Biochemical Sciences. 36: 141-50. PMID 20888775 DOI: 10.1016/j.tibs.2010.08.004  1
2011 Thornton JM. Abstracting knowledge from the PDB over 40 years Nature Structural and Molecular Biology. 18: 1313-1314. DOI: 10.1038/nsmb1211-1304  1
2010 Ochi T, Sibanda BL, Wu Q, Chirgadze DY, Bolanos-Garcia VM, Blundell TL. Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining. Journal of Nucleic Acids. 2010. PMID 20862368 DOI: 10.4061/2010/621695  1
2010 Sinha Roy R, Soni S, Harfouche R, Vasudevan PR, Holmes O, de Jonge H, Rowe A, Paraskar A, Hentschel DM, Chirgadze D, Blundell TL, Gherardi E, Mashelkar RA, Sengupta S. Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 13608-13. PMID 20639469 DOI: 10.1073/pnas.1006007107  1
2010 Worth CL, Blundell TL. On the evolutionary conservation of hydrogen bonds made by buried polar amino acids: the hidden joists, braces and trusses of protein architecture. Bmc Evolutionary Biology. 10: 161. PMID 20513243 DOI: 10.1186/1471-2148-10-161  1
2010 Murray CW, Blundell TL. Structural biology in fragment-based drug design. Current Opinion in Structural Biology. 20: 497-507. PMID 20471246 DOI: 10.1016/  1
2010 Dias MV, Huang F, Chirgadze DY, Tosin M, Spiteller D, Dry EF, Leadlay PF, Spencer JB, Blundell TL. Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK. The Journal of Biological Chemistry. 285: 22495-504. PMID 20430898 DOI: 10.1074/jbc.M110.107177  1
2010 Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. Journal of the American Chemical Society. 132: 4544-5. PMID 20232910 DOI: 10.1021/ja100595u  1
2010 D'Arcy S, Davies OR, Blundell TL, Bolanos-Garcia VM. Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition. The Journal of Biological Chemistry. 285: 14764-76. PMID 20220147 DOI: 10.1074/jbc.M109.082016  1
2010 Gong S, Blundell TL. Structural and functional restraints on the occurrence of single amino acid variations in human proteins. Plos One. 5: e9186. PMID 20169194 DOI: 10.1371/journal.pone.0009186  1
2010 Sridharan S, Howard N, Kerbarh O, B?aszczyk M, Abell C, Blundell TL. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes. Journal of Molecular Biology. 397: 290-300. PMID 20079748 DOI: 10.1016/j.jmb.2010.01.019  1
2010 Sibanda BL, Chirgadze DY, Blundell TL. Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature. 463: 118-21. PMID 20023628 DOI: 10.1038/nature08648  1
2010 Ricketts CJ, Forman JR, Rattenberry E, Bradshaw N, Lalloo F, Izatt L, Cole TR, Armstrong R, Kumar VK, Morrison PJ, Atkinson AB, Douglas F, Ball SG, Cook J, Srirangalingam U, ... ... Blundell TL, et al. Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD. Human Mutation. 31: 41-51. PMID 19802898 DOI: 10.1002/humu.21136  1
2009 Reis NM, Chirgadze DY, Blundell TL, Mackley MR. The effect of protein-precipitant interfaces and applied shear on the nucleation and growth of lysozyme crystals. Acta Crystallographica. Section D, Biological Crystallography. 65: 1127-39. PMID 19923710 DOI: 10.1107/S0907444909031527  1
2009 Blundell TL, Bolanos-Garcia VM. Targeting protein interactions of p53 for therapeutic intervention: success in a frustrated landscape. Cell Cycle (Georgetown, Tex.). 8: 3631-2. PMID 19875920  1
2009 Higueruelo AP, Schreyer A, Bickerton GR, Pitt WR, Groom CR, Blundell TL. Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database. Chemical Biology & Drug Design. 74: 457-67. PMID 19811506 DOI: 10.1111/j.1747-0285.2009.00889.x  1
2009 Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angewandte Chemie (International Ed. in English). 48: 8452-6. PMID 19780086 DOI: 10.1002/anie.200903821  1
2009 Lee S, Brown A, Pitt WR, Higueruelo AP, Gong S, Bickerton GR, Schreyer A, Tanramluk D, Baylay A, Blundell TL. Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics. Molecular Biosystems. 5: 1456-72. PMID 19763326 DOI: 10.1039/B906402h  1
2009 Worth CL, Gong S, Blundell TL. Structural and functional constraints in the evolution of protein families. Nature Reviews. Molecular Cell Biology. 10: 709-20. PMID 19756040 DOI: 10.1038/nrm2762  1
2009 Gong S, Worth CL, Bickerton GR, Lee S, Tanramluk D, Blundell TL. Structural and functional restraints in the evolution of protein families and superfamilies. Biochemical Society Transactions. 37: 727-33. PMID 19614584 DOI: 10.1042/BST0370727  1
2009 Truman AW, Dias MV, Wu S, Blundell TL, Huang F, Spencer JB. Chimeric glycosyltransferases for the generation of hybrid glycopeptides. Chemistry & Biology. 16: 676-85. PMID 19549605 DOI: 10.1016/j.chembiol.2009.04.013  1
2009 Tanramluk D, Schreyer A, Pitt WR, Blundell TL. On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine. Chemical Biology & Drug Design. 74: 16-24. PMID 19519740 DOI: 10.1111/j.1747-0285.2009.00832.x  1
2009 Appert A, Nam CH, Lobato N, Priego E, Miguel RN, Blundell T, Drynan L, Sewell H, Tanaka T, Rabbitts T. Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia. Cancer Research. 69: 4784-90. PMID 19487290 DOI: 10.1158/0008-5472.CAN-08-4774  1
2009 Lee S, Blundell TL. Ulla: a program for calculating environment-specific amino acid substitution tables. Bioinformatics (Oxford, England). 25: 1976-7. PMID 19417059 DOI: 10.1093/bioinformatics/btp300  1
2009 Forman JR, Worth CL, Bickerton GR, Eisen TG, Blundell TL. Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis. Proteins. 77: 84-96. PMID 19408298 DOI: 10.1002/prot.22419  1
2009 Lee S, Blundell TL. BIPA: a database for protein-nucleic acid interaction in 3D structures. Bioinformatics (Oxford, England). 25: 1559-60. PMID 19357098 DOI: 10.1093/bioinformatics/btp243  1
2009 Schreyer A, Blundell T. CREDO: a protein-ligand interaction database for drug discovery. Chemical Biology & Drug Design. 73: 157-67. PMID 19207418 DOI: 10.1111/j.1747-0285.2008.00762.x  1
2009 Karmali AM, Blundell TL, Furnham N. Model-building strategies for low-resolution X-ray crystallographic data. Acta Crystallographica. Section D, Biological Crystallography. 65: 121-7. PMID 19171966 DOI: 10.1107/S0907444908040006  1
2009 Bolanos-Garcia VM, Kiyomitsu T, D'Arcy S, Chirgadze DY, Grossmann JG, Matak-Vinkovic D, Venkitaraman AR, Yanagida M, Robinson CV, Blundell TL. The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores. Structure (London, England : 1993). 17: 105-16. PMID 19141287 DOI: 10.1016/j.str.2008.10.015  1
2009 Worth CL, Blundell TL. Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains. Proteins. 75: 413-29. PMID 18837037 DOI: 10.1002/prot.22248  1
2009 Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme Nato Science For Peace and Security Series a: Chemistry and Biology. 21-36. DOI: 10.1007/978-90-481-2339-1-3  1
2009 Heikkila TJ, Surade S, Silvestre HL, Dias MVB, Ciulli A, Bromfield K, Scott D, Howard N, Wen S, Wei AH, Osborne D, Abell C, Blundell TL. Fragment-based drug discovery in academia: Experiences from a tuberculosis programme Nato Science For Peace and Security Series a: Chemistry and Biology. 21-36.  1
2008 Montalvao RW, Cavalli A, Salvatella X, Blundell TL, Vendruscolo M. Structure determination of protein-protein complexes using NMR chemical shifts: case of an endonuclease colicin-immunity protein complex. Journal of the American Chemical Society. 130: 15990-6. PMID 18980319 DOI: 10.1021/ja805258z  1
2008 Cheng TM, Blundell TL, Fernandez-Recio J. Structural assembly of two-domain proteins by rigid-body docking. Bmc Bioinformatics. 9: 441. PMID 18925951 DOI: 10.1186/1471-2105-9-441  1
2008 Gong S, Blundell TL. Discarding functional residues from the substitution table improves predictions of active sites within three-dimensional structures. Plos Computational Biology. 4: e1000179. PMID 18833291 DOI: 10.1371/journal.pcbi.1000179  1
2008 Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, Abell C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. Chembiochem : a European Journal of Chemical Biology. 9: 2606-11. PMID 18821554 DOI: 10.1002/cbic.200800437  1
2008 Cheng TM, Lu YE, Vendruscolo M, Lio' P, Blundell TL. Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms. Plos Computational Biology. 4: e1000135. PMID 18654622 DOI: 10.1371/journal.pcbi.1000135  1
2008 Núñez Miguel R, Sanders J, Chirgadze DY, Blundell TL, Furmaniak J, Rees Smith B. FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity. Journal of Molecular Endocrinology. 41: 145-64. PMID 18606720 DOI: 10.1677/JME-08-0040  1
2008 Goodger SJ, Robinson CJ, Murphy KJ, Gasiunas N, Harmer NJ, Blundell TL, Pye DA, Gallagher JT. Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms. The Journal of Biological Chemistry. 283: 13001-8. PMID 18281281 DOI: 10.1074/jbc.M704531200  1
2008 Furnham N, de Bakker PI, Gore S, Burke DF, Blundell TL. Comparative modelling by restraint-based conformational sampling. Bmc Structural Biology. 8: 7. PMID 18237407 DOI: 10.1186/1472-6807-8-7  1
2008 Li Y, Chirgadze DY, Bolanos-Garcia VM, Sibanda BL, Davies OR, Ahnesorg P, Jackson SP, Blundell TL. Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ Embo Journal. 27: 290-300. PMID 18046455 DOI: 10.1038/sj.emboj.7601942  1
2008 Gore S, Blundell T. Optimal side-chain packing in proteins and crystallographic refinement Journal of Applied Crystallography. 41: 319-328. DOI: 10.1107/S0021889808001672  1
2008 Blundell TL. Structural Correlations in Families of Homologous Proteins Structure Correlation. 1: 669-683. DOI: 10.1002/9783527616091.ch16  1
2007 Worth CL, Bickerton GR, Schreyer A, Forman JR, Cheng TM, Lee S, Gong S, Burke DF, Blundell TL. A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease. Journal of Bioinformatics and Computational Biology. 5: 1297-318. PMID 18172930 DOI: 10.1142/S0219720007003120  1
2007 Blundell T. New Dimensions of Structural Proteomics: Exploring Chemical and Biological Space Structure. 15: 1342-1343. PMID 17997956 DOI: 10.1016/j.str.2007.10.008  1
2007 King JD, Harmer NJ, Preston A, Palmer CM, Rejzek M, Field RA, Blundell TL, Maskell DJ. Predicting Protein Function from Structure-The Roles of Short-chain Dehydrogenase/Reductase Enzymes in Bordetella O-antigen Biosynthesis Journal of Molecular Biology. 374: 749-763. PMID 17950751 DOI: 10.1016/j.jmb.2007.09.055  1
2007 Porollo A, Meller J. Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. Bmc Bioinformatics. 8: 316. PMID 17727718 DOI: 10.1186/1471-2105-8-316  1
2007 Burke DF, Worth CL, Priego EM, Cheng T, Smink LJ, Todd JA, Blundell TL. Genome bioinformatic analysis of nonsynonymous SNPs. Bmc Bioinformatics. 8: 301. PMID 17708757 DOI: 10.1186/1471-2105-8-301  0.32
2007 Harmer NJ, King JD, Palmer CM, Preston A, Maskell DJ, Blundell TL. Cloning, expression, purification and preliminary crystallographic analysis of the short-chain dehydrogenase enzymes WbmF, WbmG and WbmH from Bordetella bronchiseptica Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63: 711-715. PMID 17671375 DOI: 10.1107/S174430910703477X  1
2007 Sanders J, Chirgadze DY, Sanders P, Baker S, Sullivan A, Bhardwaja A, Bolton J, Reeve M, Nakatake N, Evans M, Richards T, Powell M, Miguel RN, Blundell TL, Furmaniak J, et al. Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody Thyroid. 17: 395-410. PMID 17542669 DOI: 10.1089/thy.2007.0034  1
2007 Cheng TMK, Blundell TL, Fernandez-Recio J. PyDock: Electrostatics and desolvation for effective scoring of rigid-body protein-protein docking Proteins: Structure, Function and Genetics. 68: 503-515. PMID 17444519 DOI: 10.1002/prot.21419  1
2007 Gore SP, Karmali AM, Blundell TL. Rappertk: A versatile engine for discrete restraint-based conformational sampling of macromolecules Bmc Structural Biology. 7. PMID 17376228 DOI: 10.1186/1472-6807-7-13  1
2007 Smith RE, Lovell SC, Burke DF, Montalvao RW, Blundell TL. Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities. Bioinformatics (Oxford, England). 23: 1099-105. PMID 17341496 DOI: 10.1093/bioinformatics/btm073  1
2007 Kerbarh O, Ciulli A, Chirgadze DY, Blundell TL, Abell C. Nucleophile selectivity of chorismate-utilizing enzymes. Chembiochem : a European Journal of Chemical Biology. 8: 622-4. PMID 17335098 DOI: 10.1002/cbic.200700019  1
2007 Ciulli A, Lobley CM, Tuck KL, Smith AG, Blundell TL, Abell C. pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study. Acta Crystallographica. Section D, Biological Crystallography. 63: 171-8. PMID 17242510 DOI: 10.1107/S0907444906044465  1
2007 Ciulli A, Chirgadze DY, Smith AG, Blundell TL, Abell C. Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: Substrate recognition, conformational change, and cooperativity Journal of Biological Chemistry. 282: 8487-8497. PMID 17229734 DOI: 10.1074/jbc.M611171200  1
2007 Ciulli A, Blundell TL, Abell C. Discovery and extrapolation of fragment structures towards drug design Rsc Biomolecular Sciences. 293-318.  1
2006 Bolanos-Garcia VM, Fernandez-Recio J, Allende JE, Blundell TL. Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit. Trends in Biochemical Sciences. 31: 654-61. PMID 17084631 DOI: 10.1016/j.tibs.2006.10.005  1
2006 Blundell TL, Fernández-Recio J. Cell biology: Brief encounters bolster contacts Nature. 444: 279-280. PMID 17051147 DOI: 10.1038/nature05306  1
2006 Furnham N, Doré AS, Chirgadze DY, de Bakker PI, Depristo MA, Blundell TL. Knowledge-based real-space explorations for low-resolution structure determination. Structure (London, England : 1993). 14: 1313-20. PMID 16905105 DOI: 10.1016/j.str.2006.06.014  1
2006 Popovic B, Tang X, Chirgadze DY, Huang F, Blundell TL, Spencer JB. Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis. Proteins. 65: 220-30. PMID 16894611 DOI: 10.1002/prot.21076  1
2006 Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Probing hot spots at protein-ligand binding sites: A fragment-based approach using biophysical methods Journal of Medicinal Chemistry. 49: 4992-5000. PMID 16884311 DOI: 10.1021/jm060490r  1
2006 Ryu EK, Cho KJ, Kim JK, Harmer NJ, Blundell TL, Kim KH. Expression and purification of recombinant human fibroblast growth factor receptor in Escherichia coli Protein Expression and Purification. 49: 15-22. PMID 16750394 DOI: 10.1016/j.pep.2006.04.008  1
2006 Hoskins J, Lovell S, Blundell TL. An algorithm for predicting protein-protein interaction sites: Abnormally exposed amino acid residues and secondary structure elements Protein Science. 15: 1017-1029. PMID 16641487 DOI: 10.1110/ps.051589106  1
2006 Gherardi E, Sandin S, Petoukhov MV, Finch J, Youles ME, Öfverstedt LG, Miguel RN, Blundell TL, Vande Woude GF, Skoglund U, Svergun DI. Structural basis of hepatocyte growth factor/scatter factor and MET signalling Proceedings of the National Academy of Sciences of the United States of America. 103: 4046-4051. PMID 16537482 DOI: 10.1073/pnas.0509040103  1
2006 Blundell TL, Sibanda BL, Montalvão RW, Brewerton S, Chelliah V, Worth CL, Harmer NJ, Davies O, Burke D. Structural biology and bioinformatics in drug design: Opportunities and challenges for target identification and lead discovery Philosophical Transactions of the Royal Society B: Biological Sciences. 361: 413-423. PMID 16524830 DOI: 10.1098/rstb.2005.1800  1
2006 Furnham N, Blundell TL, DePristo MA, Terwilliger TC. Is one solution good enough? Nature Structural & Molecular Biology. 13: 184-5; discussion 18. PMID 16518382 DOI: 10.1038/nsmb0306-184  1
2006 Chelliah V, Blundell TL, Fernández-Recio J. Efficient restraints for protein-protein docking by comparison of observed amino acid substitution patterns with those predicted from local environment Journal of Molecular Biology. 357: 1669-1682. PMID 16488431 DOI: 10.1016/j.jmb.2006.01.001  1
2006 de Bakker PI, Furnham N, Blundell TL, DePristo MA. Conformer generation under restraints. Current Opinion in Structural Biology. 16: 160-5. PMID 16483766 DOI: 10.1016/  1
2006 Kerbarh O, Chirgadze DY, Blundell TL, Abell C. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate Journal of Molecular Biology. 357: 524-534. PMID 16434053 DOI: 10.1016/j.jmb.2005.12.078  1
2006 Doré AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL. Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. Dna Repair. 5: 362-8. PMID 16388993 DOI: 10.1016/j.dnarep.2005.11.004  1
2006 Harmer NJ, Robinson CJ, Adam LE, Ilag LL, Robinson CV, Gallagher JT, Blundell TL. Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin. The Biochemical Journal. 393: 741-8. PMID 16223363 DOI: 10.1042/BJ20050985  1
2005 Miguel RN, Chen S, Nikfarjam L, Kominami S, Carpenter B, Pra CD, Betterle C, Zanchetta R, Nakamatsu T, Powell M, Hewer R, Blundell TL, Smith BR, Furmaniak J. Analysis of the interaction between human steroid 21-hydroxylase and various monoclonal antibodies using comparative structural modelling European Journal of Endocrinology. 153: 949-961. PMID 16322402 DOI: 10.1530/eje.1.02044  1
2005 Carafoli F, Chirgadze DY, Blundell TL, Gherardi E. Crystal structure of the β-chain of human hepatocyte growth factor-like/macrophage stimulating protein Febs Journal. 272: 5799-5807. PMID 16279944 DOI: 10.1111/j.1742-4658.2005.04968.x  1
2005 Robinson CJ, Harmer NJ, Goodger SJ, Blundell TL, Gallagher JT. Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes. The Journal of Biological Chemistry. 280: 42274-82. PMID 16219767 DOI: 10.1074/jbc.M505720200  1
2005 Chelliah V, Blundell T, Mizuguchi K. Functional restraints on the patterns of amino acid substitutions: Application to sequence-structure homology recognition Proteins: Structure, Function and Genetics. 61: 722-731. PMID 16193489 DOI: 10.1002/prot.20617  1
2005 Núñez Miguel R, Sanders J, Blundell TL, Rees Smith B, Furmaniak J. Comparative modeling of the thyrotropin receptor [2] Thyroid. 15: 746-747. PMID 16178067 DOI: 10.1089/thy.2005.15.746  1
2005 DePristo MA, De Bakker PIW, Johnson RJK, Blundell TL. Crystallographic refinement by knowledge-based exploration of complex energy landscapes Structure. 13: 1311-1319. PMID 16154088 DOI: 10.1016/j.str.2005.06.008  1
2005 Sanders J, Allen F, Jeffreys J, Bolton J, Richards T, Depraetere H, Nakatake N, Evans M, Kiddie A, Premawardhana LDKE, Chirgadze DY, Núñez Miguel R, Blundell TL, Furmaniak J, Rees Smith B. Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist Thyroid. 15: 672-682. PMID 16053383 DOI: 10.1089/thy.2005.15.672  1
2005 Montalvão RW, Smith RE, Lovell SC, Blundell TL. CHORAL: a differential geometry approach to the prediction of the cores of protein structures. Bioinformatics (Oxford, England). 21: 3719-25. PMID 16046494 DOI: 10.1093/bioinformatics/bti595  1
2005 Bolanos-Garcia VM, Beaufils S, Renault A, Grossmann JG, Brewerton S, Lee M, Venkitaraman A, Blundell TL. The conserved N-terminal region of the mitotic checkpoint protein BUBR1: A putative TPR motif of high surface activity Biophysical Journal. 89: 2640-2649. PMID 16040755 DOI: 10.1529/biophysj.105.063511  1
2005 Ehebauer MT, Chirgadze DY, Hayward P, Martinez Arias A, Blundell TL. High-resolution crystal structure of the human Notch 1 ankyrin domain. The Biochemical Journal. 392: 13-20. PMID 16011479 DOI: 10.1042/BJ20050515  1
2005 Aurikko JP, Ruotolo BT, Grossmann JG, Moncrieffe MC, Stephens E, Leppänen VM, Robinson CV, Saarma M, Bradshaw RA, Blundell TL. Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR. The Journal of Biological Chemistry. 280: 33453-60. PMID 16009712 DOI: 10.1074/jbc.M503189200  1
2005 Congreve M, Murray CW, Blundell TL. Structural biology and drug discovery. Drug Discovery Today. 10: 895-907. PMID 15993809 DOI: 10.1016/S1359-6446(05)03484-7  1
2005 Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL. The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. Biochemistry. 44: 8930-9. PMID 15966718 DOI: 10.1021/bi0502036  1
2005 Gore SP, Burke DF, Blundell TL. PROVAT: A tool for Voronoi tessellation analysis of protein structures and complexes Bioinformatics. 21: 3316-3317. PMID 15932902 DOI: 10.1093/bioinformatics/bti523  1
2005 Blundell TL. Advances in the uses of synchrotron X-ray and proton beams in structural biology Progress in Biophysics and Molecular Biology. 89: 121-123. PMID 15910914 DOI: 10.1016/j.pbiomolbio.2004.09.002  1
2005 Adams N, Bigmore HR, Blundell TL, Boyd CL, Dubberley SR, Sealey AJ, Cowley AR, Skinner ME, Mountford P. New titanium imido synthons: syntheses and supramolecular structures. Inorganic Chemistry. 44: 2882-94. PMID 15819576 DOI: 10.1021/ic050011z  1
2005 Messenger NJ, Kabitschke C, Andrews R, Grimmer D, Núñez Miguel R, Blundell TL, Smith JC, Wardle FC. Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1. Developmental Cell. 8: 599-610. PMID 15809041 DOI: 10.1016/j.devcel.2005.03.001  1
2005 Harmer NJ, Sivak JM, Amaya E, Blundell TL. 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family. Febs Letters. 579: 1161-6. PMID 15710406 DOI: 10.1016/j.febslet.2004.11.114  1
2005 Cubellis MV, Caillez F, Blundell TL, Lovell SC. Properties of polyproline II, a secondary structure element implicated in protein-protein interactions Proteins: Structure, Function and Genetics. 58: 880-892. PMID 15657931 DOI: 10.1002/prot.20327  1
2005 Blundell TL. The developing art of protein crystallisation: New advances from improved knowledge automation and miniaturisation Progress in Biophysics and Molecular Biology. 88: 283-284. PMID 15652245 DOI: 10.1016/j.pbiomolbio.2004.07.002  1
2005 Blundell TL. New strategies for structure-guided design of AIDS antivirals Progress in Biophysics and Molecular Biology. 88: 191-192. PMID 15572154 DOI: 10.1016/j.pbiomolbio.2004.07.004  1
2005 Chelliah V, Blundell TL. Quantifying structural and functional restraints on amino acid substitutions in evolution of proteins Biokhimiya. 70: 1013-1020. DOI: 10.1007/s10541-005-0192-2  1
2004 Miguel RN, Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Blundell TL, Smith BR, Furmaniak J. Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling Thyroid. 14: 991-1011. PMID 15650352 DOI: 10.1089/thy.2004.14.991  1
2004 Bertrand L, Sayed MF, Pei XY, Parisini E, Dhanaraj V, Bolanos-Garcia VM, Allende JE, Blundell TL. Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop. Acta Crystallographica. Section D, Biological Crystallography. 60: 1698-704. PMID 15388915 DOI: 10.1107/S0907444904016750  1
2004 Chelliah V, Chen L, Blundell TL, Lovell SC. Distinguishing structural and functional restraints in evolution in order to identify interaction sites Journal of Molecular Biology. 342: 1487-1504. PMID 15364576 DOI: 10.1016/j.jmb.2004.08.022  1
2004 Blundell TL, Patel S. High-throughput X-ray crystallography for drug discovery Current Opinion in Pharmacology. 4: 490-496. PMID 15351354 DOI: 10.1016/j.coph.2004.04.007  1
2004 Sanders J, Jeffreys J, Depraetere H, Evans M, Richards T, Kiddie A, Brereton K, Premawardhana LDKE, Chirgadze DY, Miguel RN, Blundell TL, Furmaniak J, Smith BR. Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: Sequence structure and function Thyroid. 14: 560-570. PMID 15320966 DOI: 10.1089/1050725041692918  1
2004 Harmer NJ, Ilag LL, Mulloy B, Pellegrini L, Robinson CV, Blundell TL. Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex Journal of Molecular Biology. 339: 821-834. PMID 15165853 DOI: 10.1016/j.jmb.2004.04.031  1
2004 DePristo MA, De Bakker PIW, Blundell TL. Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography Structure. 12: 831-838. PMID 15130475 DOI: 10.1016/j.str.2004.02.031  1
2004 González B, Pajares MA, Martínez-Ripoll M, Blundell TL, Sanz-Aparicio J. Crystal structure of rat liver betaine homocysteine S-methyltransferase reveals new oligomerization features and conformational changes upon substrate binding Journal of Molecular Biology. 338: 771-782. PMID 15099744 DOI: 10.1016/j.jmb.2004.03.005  1
2004 Brewerton SC, Doré AS, Drake ACB, Leuther KK, Blundell TL. Structural analysis of DNA-PKcs: Modelling of the repeat units and insights into the detailed molecular architecture Journal of Structural Biology. 145: 295-306. PMID 14960380 DOI: 10.1016/j.jsb.2003.11.024  1
2004 Harmer NJ, Pellegrini L, Chirgadze D, Fernandez-Recio J, Blundell TL. The Crystal Structure of Fibroblast Growth Factor (FGF) 19 Reveals Novel Features of the FGF Family and Offers a Structural Basis for Its Unusual Receptor Affinity Biochemistry. 43: 629-640. PMID 14730967 DOI: 10.1021/bi035320k  1
2004 Doré AS, Drake ACB, Brewerton SC, Blundell TL. Identification of DNA-PK in the arthropods: Evidence for the ancient ancestry of vertebrate non-homologous end-joining Dna Repair. 3: 33-41. PMID 14697757 DOI: 10.1016/j.dnarep.2003.09.003  1
2004 Ottenhof HH, Ashurst JL, Whitney HM, Saldanha SA, Schmitzberger F, Gweon HS, Blundell TL, Abell C, Smith AG. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. The Plant Journal : For Cell and Molecular Biology. 37: 61-72. PMID 14675432 DOI: 10.1046/j.1365-313X.2003.01940.x  1
2004 Badasso MO, Dhanaraj V, Wood SP, Cooper JB, Blundell TL. Crystallization and X-ray analysis of the Y75N mutant of Mucor pusillus pepsin complexed with inhibitor Acta Crystallographica Section D: Biological Crystallography. 60: 770-772. DOI: 10.1107/S0907444904003221  1
2003 Shetty RP, De Bakker PIW, DePristo MA, Blundell TL. Advantages of fine-grained side chain conformer libraries Protein Engineering. 16: 963-969. PMID 14983076  1
2003 Schmitzberger F, Kilkenny ML, Lobley CMC, Webb ME, Vinkovic M, Matak-Vinkovic D, Witty M, Chirgadze DY, Smith AG, Abel C, Blundell TL. Structural constraints on protein self-processing in L-aspartate-α -decarboxylase Embo Journal. 22: 6193-6204. PMID 14633979 DOI: 10.1093/emboj/cdg575  1
2003 Yu DS, Sonoda E, Takeda S, Huang CLH, Pellegrini L, Blundell TL, Venkitaraman AR. Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2 Molecular Cell. 12: 1029-1041. PMID 14580352 DOI: 10.1016/S1097-2765(03)00394-0  1
2003 Gherardi E, Youles ME, Miguel RN, Blundell TL, Iamele L, Gough J, Bandyopadhyay A, Hartmann G, Butler PJG. Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor Proceedings of the National Academy of Sciences of the United States of America. 100: 12039-12044. PMID 14528000 DOI: 10.1073/pnas.2034936100  1
2003 Owen D, Lowe PN, Nietlispach D, Brosnan CE, Chirgadze DY, Parker PJ, Blundell TL, Mott HR. Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1). The Journal of Biological Chemistry. 278: 50578-87. PMID 14514689 DOI: 10.1074/jbc.M304313200  1
2003 Vinayagam A, Shi J, Pugalenthi G, Meenakshi B, Blundell TL, Sowdhamini R. DDBASE2.0: Updated domain database with improved identification of structural domains Bioinformatics. 19: 1760-1764. PMID 14512346 DOI: 10.1093/bioinformatics/btg233  1
2003 Lo T, Pellegrini L, Venkitaraman AR, Blundell TL. Sequence fingerprints in BRCA2 and RAD51: Implications for DNA repair and cancer Dna Repair. 2: 1015-1028. PMID 12967658 DOI: 10.1016/S1568-7864(03)00097-1  1
2003 Miguel RN, Sanders J, Jeffreys J, Depraetere H, Blundell T, Furmaniak J, Smith BR. Thyrotropin receptor cleavage domain and tissue inhibitor of metalloproteinase-2 [2] Thyroid. 13: 665-666. PMID 12964975  1
2003 Shin DS, Pellegrini L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK, Hitomi C, Arvai AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA. Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. The Embo Journal. 22: 4566-76. PMID 12941707 DOI: 10.1093/emboj/cdg429  1
2003 Depristo MA, De Bakker PIW, Shetty RP, Blundell TL. Discrete restraint-based protein modeling and the Cα-trace problem Protein Science. 12: 2032-2046. PMID 12931001 DOI: 10.1110/ps.0386903  1
2003 Von Delft F, Inoue T, Saldanha SA, Ottenhof HH, Schmitzberger F, Birch LM, Dhanaraj V, Witty M, Smith AG, Blundell TL, Abell C. Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites Structure. 11: 985-996. PMID 12906829 DOI: 10.1016/S0969-2126(03)00158-8  1
2003 Schmitzberger F, Smith AG, Abell C, Blundell TL. Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (βα)8 phosphoenolpyruvate/pyruvate superfamily Journal of Bacteriology. 185: 4163-4171. PMID 12837791 DOI: 10.1128/JB.185.14.4163-4171.2003  1
2003 Lobley CM, Schmitzberger F, Kilkenny ML, Whitney H, Ottenhof HH, Chakauya E, Webb ME, Birch LM, Tuck KL, Abell C, Smith AG, Blundell TL. Structural insights into the evolution of the pantothenate-biosynthesis pathway. Biochemical Society Transactions. 31: 563-71. PMID 12773157 DOI: 10.1042/  1
2003 Evans PC, Smith TS, Lai MJ, Williams MG, Burke DF, Heyninck K, Kreike MM, Beyaert R, Blundell TL, Kilshaw PJ. A novel type of deubiquitinating enzyme. The Journal of Biological Chemistry. 278: 23180-6. PMID 12682062 DOI: 10.1074/jbc.M301863200  1
2003 Deane CM, Blundell TL. Protein Comparative Modelling and Drug Discovery The Practice of Medicinal Chemistry: Second Edition. 445-458. DOI: 10.1016/B978-012744481-9/50031-3  1
2001 Williams MG, Shirai H, Shi J, Nagendra HG, Mueller J, Mizuguchi K, Miguel RN, Lovell SC, Innis CA, Deane CM, Chen L, Campillo N, Burke DF, Blundell TL, de Bakker PI. Sequence-structure homology recognition by iterative alignment refinement and comparative modeling. Proteins. 92-7. PMID 11835486 DOI: 10.1002/prot.1169  0.32
2001 Deane CM, Blundell TL. CODA: a combined algorithm for predicting the structurally variable regions of protein models. Protein Science : a Publication of the Protein Society. 10: 599-612. PMID 11344328 DOI: 10.1110/ps.37601  0.32
2000 Deane CM, Blundell TL. A novel exhaustive search algorithm for predicting the conformation of polypeptide segments in proteins. Proteins. 40: 135-44. PMID 10813838 DOI: 10.1002/(SICI)1097-0134(20000701)40:1<135::AID-PROT150>3.0.CO;2-1  0.32
1999 Nagarajaram HA, Reddy BV, Blundell TL. Analysis and prediction of inter-strand packing distances between beta-sheets of globular proteins. Protein Engineering. 12: 1055-62. PMID 10611399  1
1999 Burke DF, Deane CM, Nagarajaram HA, Campillo N, Martin-Martinez M, Mendes J, Molina F, Perry J, Reddy BV, Soares CM, Steward RE, Williams M, Carrondo MA, Blundell TL, Mizuguchi K. An iterative structure-assisted approach to sequence alignment and comparative modeling. Proteins. 55-60. PMID 10526352 DOI: 10.1002/(SICI)1097-0134(1999)37:3+<55::AID-PROT8>3.0.CO;2-B  1
1999 Srinivasan N, Antonelli M, Jacob G, Korn I, Romero F, Jedlicki A, Dhanaraj V, Sayed MF, Blundell TL, Allende CC, Allende JE. Structural interpretation of site-directed mutagenesis and specificity of the catalytic subunit of protein kinase CK2 using comparative modelling. Protein Engineering. 12: 119-27. PMID 10195283  1
1999 Reddy BV, Nagarajaram HA, Blundell TL. Analysis of interactive packing of secondary structural elements in alpha/beta units in proteins. Protein Science : a Publication of the Protein Society. 8: 573-86. PMID 10091660 DOI: 10.1110/ps.8.3.573  1
1999 Chirgadze DY, Hepple JP, Zhou H, Byrd RA, Blundell TL, Gherardi E. Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding. Nature Structural Biology. 6: 72-9. PMID 9886295 DOI: 10.1038/4947  0.4
1998 Sowdhamini R, Burke DF, Deane C, Huang JF, Mizuguchi K, Nagarajaram HA, Overington JP, Srinivasan N, Steward RE, Blundell TL. Protein three-dimensional structural databases: domains, structurally aligned homologues and superfamilies. Acta Crystallographica. Section D, Biological Crystallography. 54: 1168-77. PMID 10089493 DOI: 10.1107/S0907444998007148  1
1998 Groves MR, Dhanaraj V, Badasso M, Nugent P, Pitts JE, Hoover DJ, Blundell TL. A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure. Protein Engineering. 11: 833-40. PMID 9862200 DOI: 10.1093/PROTEIN/11.10.833  1
1998 Mizuguchi K, Deane CM, Blundell TL, Overington JP. HOMSTRAD: a database of protein structure alignments for homologous families. Protein Science : a Publication of the Protein Society. 7: 2469-71. PMID 9828015 DOI: 10.1002/pro.5560071126  1
1998 Sowdhamini R, Burke DF, Huang JF, Mizuguchi K, Nagarajaram HA, Srinivasan N, Steward RE, Blundell TL. CAMPASS: a database of structurally aligned protein superfamilies. Structure (London, England : 1993). 6: 1087-94. PMID 9753697 DOI: 10.1016/S0969-2126(98)00110-5  1
1998 Loew A, Ho YK, Blundell T, Bax B. Phosducin induces a structural change in transducin beta gamma. Structure (London, England : 1993). 6: 1007-19. PMID 9739091 DOI: 10.1016/s0969-2126(98)00102-6  0.44
1998 Mizuguchi K, Deane CM, Blundell TL, Johnson MS, Overington JP. JOY: protein sequence-structure representation and analysis. Bioinformatics (Oxford, England). 14: 617-23. PMID 9730927 DOI: 10.1093/bioinformatics/14.7.617  1
1998 Chirgadze DY, Hepple J, Byrd RA, Sowdhamini R, Blundell TL, Gherardi E. Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation. Febs Letters. 430: 126-9. PMID 9678607 DOI: 10.1016/s0014-5793(98)00558-4  0.4
1998 Snook CF, Woolley GA, Oliva G, Pattabhi V, Wood SP, Blundell TL, Wallace BA. The structure and function of antiamoebin I, a proline-rich membrane-active polypeptide Structure. 6: 783-792. PMID 9655831 DOI: 10.1016/S0969-2126(98)00079-3  1
1997 Bax B, Blundell TL, Murray-Rust J, McDonald NQ. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure (London, England : 1993). 5: 1275-85. PMID 9351801  1
1997 Aguilar CF, Cronin NB, Badasso M, Dreyer T, Newman MP, Cooper JB, Hoover DJ, Wood SP, Johnson MS, Blundell TL. The three-dimensional structure at 2.4 Å resolution of glycosylated proteinase A from the lysosome-like vacuole of Saccharomyces cerevisiae Journal of Molecular Biology. 267: 899-915. PMID 9135120 DOI: 10.1006/jmbi.1996.0880  1
1997 Sowdhamini R, Rufino SD, Blundell TL. A database of globular protein structural domains: clustering of representative family members into similar folds. Folding & Design. 1: 209-20. PMID 9079382 DOI: 10.1016/S1359-0278(96)00032-6  0.44
1997 Topham CM, Srinivasan N, Blundell TL. Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables. Protein Engineering. 10: 7-21. PMID 9051729 DOI: 10.1093/PROTEIN/10.1.7  0.4
1996 Blundell TL, Srinivasan N. Symmetry, stability, and dynamics of multidomain and multicomponent protein systems Proceedings of the National Academy of Sciences of the United States of America. 93: 14243-14248. PMID 8962033 DOI: 10.1073/pnas.93.25.14243  1
1996 Guruprasad K, Blundell TL, Xie S, Green J, Szafranska B, Nagel RJ, McDowell K, Baker CB, Roberts RM. Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases. Protein Engineering. 9: 849-56. PMID 8931124 DOI: 10.1093/PROTEIN/9.10.849  1
1996 Srinivasan N, Bax B, Blundell TL, Parker PJ. Structural aspects of the functional modules in human protein kinase- Cα deduced from comparative analyses Proteins: Structure, Function and Genetics. 26: 217-235. PMID 8916229 DOI: 10.1002/(SICI)1097-0134(199610)26:2<217::AID-PROT11>3.0.CO;2-S  1
1996 Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GL, Sussman JL. Archival journal requirements of macromolecular crystallographic data Journal of Biomolecular Structure & Dynamics. 13: 583. PMID 8906878 DOI: 10.1080/07391102.1996.10508870  1
1996 Baker EN, Blundell TL, Dodson E, Dodson G, Gilliland GL, Sussman JL, Vijayan M. Diffraction data deposition Structure (London, England : 1993). 4: 217. PMID 8805528 DOI: 10.1016/S0969-2126(96)00024-X  1
1996 Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GL, Sussman JL. Archival journal requirements for data deposition. Biophysical Journal. 70: 2994. PMID 8744337 DOI: 10.1016/S0006-3495(96)79869-7  1
1996 Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily. Structure (London, England : 1993). 4: 375-86. PMID 8740360 DOI: 10.1016/S0969-2126(96)00043-3  1
1996 Louie GV, Brownlie PD, Lambert R, Cooper JB, Blundell TL, Wood SP, Malashkevich VN, Hädener A, Warren MJ, Shoolingin-Jordan PM. The three-dimensional structure of Escherichia coli porphobilinogen deaminase at 1.76-Å resolution Proteins: Structure, Function and Genetics. 25: 48-78. PMID 8727319  1
1996 Baker EN, Blundell TL, Vijayan M, Dodson E, Dodson G, Gilliland GI, Sussman JL. Crystallographic data deposition Nature. 379: 202. PMID 8538780 DOI: 10.1038/379202A0  1
1995 May AC, Johnson MS, Rufino SD, Wako H, Zhu ZY, Sowdhamini R, Srinivasan N, Rodionov MA, Blundell TL. The recognition of protein structure and function from sequence: adding value to genome data. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 344: 373-81. PMID 7800707 DOI: 10.1098/RSTB.1994.0076  0.36
1995 McDonald NQ, Murray-Rust J, Blundell TL. The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action. Structure (London, England : 1993). 3: 1-6. PMID 7743124 DOI: 10.1016/S0969-2126(01)00129-0  1
1994 Sali A, Blundell TL. Comparative protein modelling by satisfaction of spatial restraints. Journal of Molecular Biology. 234: 779-815. PMID 8254673 DOI: 10.1006/JMBI.1993.1626  0.44
1994 Donnelly D, Overington JP, Blundell TL. The prediction and orientation of alpha-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules. Protein Engineering. 7: 645-53. PMID 8073034  1
1994 Whittle PJ, Blundell TL. Protein structure--based drug design. Annual Review of Biophysics and Biomolecular Structure. 23: 349-75. PMID 7919786 DOI: 10.1146/  1
1994 Bradshaw RA, Murray-Rust J, Ibáñez CF, McDonald NQ, Lapatto R, Blundell TL. Nerve growth factor: structure/function relationships. Protein Science : a Publication of the Protein Society. 3: 1901-13. PMID 7703837 DOI: 10.1002/pro.5560031102  1
1993 Johnson MS, Overington JP, Blundell TL. Alignment and searching for common protein folds using a data bank of structural templates. Journal of Molecular Biology. 231: 735-52. PMID 8515448 DOI: 10.1006/jmbi.1993.1323  1
1993 Bradshaw RA, Blundell TL, Lapatto R, McDonald NQ, Murray-Rust J. Nerve growth factor revisited. Trends in Biochemical Sciences. 18: 48-52. PMID 8488558 DOI: 10.1016/0968-0004(93)90052-O  1
1993 Scarborough PE, Guruprasad K, Topham C, Richo GR, Conner GE, Blundell TL, Dunn BM. Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling Protein Science. 2: 264-276. PMID 8443603  1
1993 Donnelly D, Overington JP, Ruffle SV, Nugent JH, Blundell TL. Modeling alpha-helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues. Protein Science : a Publication of the Protein Society. 2: 55-70. PMID 8443590 DOI: 10.1002/pro.5560020106  1
1993 Topham CM, McLeod A, Eisenmenger F, Overington JP, Johnson MS, Blundell TL. Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables. Journal of Molecular Biology. 229: 194-220. PMID 8421300 DOI: 10.1006/jmbi.1993.1018  1
1993 Srinivasan N, Blundell TL. An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure Protein Engineering, Design and Selection. 6: 501-512. PMID 8415577 DOI: 10.1093/protein/6.5.501  1
1993 Reddy BV, Blundell TL. Packing of secondary structural elements in proteins. Analysis and prediction of inter-helix distances. Journal of Molecular Biology. 233: 464-79. PMID 8411156 DOI: 10.1006/jmbi.1993.1524  1
1993 Hoffrén AM, Saloheimo M, Thomas P, Overington JP, Johnson MS, Knowles JK, Blundell TL. Modelling of the lignin peroxidase LIII of Phlebia radiata: use of a sequence template generated from a 3-D structure. Protein Engineering. 6: 177-82. PMID 8386362  1
1993 Blundell TL, Johnson MS. Catching a common fold Protein Science. 2: 877-883. PMID 8318893 DOI: 10.1002/PRO.5560020602  1
1993 Overington JP, Zhu ZY, Sali A, Johnson MS, Sowdhamini R, Louie GV, Blundell TL. Molecular recognition in protein families: a database of aligned three-dimensional structures of related proteins. Biochemical Society Transactions. 21: 597-604. PMID 8224474  1
1993 Murray-Rust J, McDonald NQ, Blundell TL, Hosang M, Oefner C, Winkler F, Bradshaw RA. Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors. Structure (London, England : 1993). 1: 153-9. PMID 8069627 DOI: 10.1016/0969-2126(93)90029-G  1
1992 Badasso M, Frazao C, Sibanda BL, Dhanaraj V, DeAlwis C, Cooper JB, Wood SP, Blundell TL, Murakami K, Miyazaki H, Hobart PM, Geoghegan KF, Ammirati MJ, Lanzetti AJ, Danley DE, et al. Crystallization and preliminary X-ray analysis of complexes of peptide inhibitors with human recombinant and mouse submandibular renins Journal of Molecular Biology. 223: 447-453. PMID 1738157 DOI: 10.1016/0022-2836(92)90663-5  1
1992 Zhu ZY, Sali A, Blundell TL. A variable gap penalty function and feature weights for protein 3-D structure comparisons. Protein Engineering. 5: 43-51. PMID 1631045 DOI: 10.1093/PROTEIN/5.1.43  0.36
1992 Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HPC, Newman M, Aguilar C, Wood SP, Blundell TL, Hobart PM, Geoghegan KF, Ammirati MJ, et al. X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins Nature. 357: 466-472. PMID 1608447 DOI: 10.1038/357466a0  1
1992 Sali A, Veerapandian B, Cooper JB, Moss DS, Hofmann T, Blundell TL. Domain flexibility in aspartic proteinases. Proteins. 12: 158-70. PMID 1603805 DOI: 10.1002/PROT.340120209  0.36
1992 Cooper J, Quail W, Frazao C, Foundling SI, Blundell TL, Humblet C, Lunney EA, Lowther WT, Dunn BM. X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors. Biochemistry. 31: 8142-50. PMID 1525155  1
1992 Overington J, Donnelly D, Johnson MS, Sali A, Blundell TL. Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds. Protein Science : a Publication of the Protein Society. 1: 216-26. PMID 1304904 DOI: 10.1002/pro.5560010203  1
1992 Veerapandian B, Cooper JB, Sali A, Blundell TL, Rosati RL, Dominy BW, Damon DB, Hoover DJ. Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases. Protein Science : a Publication of the Protein Society. 1: 322-8. PMID 1304340 DOI: 10.1002/pro.5560010303  0.68
1992 Blundell TL, Doolittle RF. Sequences and topology-An inverse approach to the old folding problem. Editorial overview Current Opinion in Structural Biology. 2: 381-383. DOI: 10.1016/0959-440X(92)90228-Y  1
1991 Veerapandian B, Cooper JB, Sali A, Blundell TL. X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution. Journal of Molecular Biology. 216: 1017-29. PMID 2266553 DOI: 10.1016/S0022-2836(99)80017-5  0.32
1991 McDonald NQ, Blundell TL. Crystallization and characterization of the high molecular weight form of nerve growth factor (7 S NGF). Journal of Molecular Biology. 219: 595-601. PMID 2056528 DOI: 10.1016/0022-2836(91)90655-P  1
1991 McDonald NQ, Lapatto R, Murray-Rust J, Gunning J, Wlodawer A, Blundell TL. New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature. 354: 411-4. PMID 1956407 DOI: 10.1038/354411a0  1
1991 Newman M, Safro M, Frazao C, Khan G, Zdanov A, Tickle IJ, Blundell TL, Andreeva N. X-ray analyses of aspartic proteinases IV. Structure and refinement at 2.2 Å resolution of bovine chymosin Journal of Molecular Biology. 221: 1295-1309. PMID 1942052 DOI: 10.1016/0022-2836(91)90934-X  1
1991 Hoover DJ, Veerapandian B, Cooper JB, Damon DB, Dominy BW, Rosati RL, Blundell TL. X-ray analysis of a difluorostatone renin inhibitor bound as the tetrahedral hydrate to the aspartic protease endothiapepsin. Advances in Experimental Medicine and Biology. 306: 269-73. PMID 1812716  1
1990 Sali A, Overington JP, Johnson MS, Blundell TL. From comparisons of protein sequences and structures to protein modelling and design. Trends in Biochemical Sciences. 15: 235-40. PMID 2200167 DOI: 10.1016/0968-0004(90)90036-B  1
1990 Sali A, Blundell TL. Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming. Journal of Molecular Biology. 212: 403-28. PMID 2181150 DOI: 10.1016/0022-2836(90)90134-8  0.32
1990 Johnson MS, Sali A, Blundell TL. Phylogenetic relationships from three-dimensional protein structures. Methods in Enzymology. 183: 670-90. PMID 2156133 DOI: 10.1016/0076-6879(90)83044-A  0.56
1990 Topham CM, Thomas P, Overington JP, Johnson MS, Eisenmenger F, Blundell TL. An assessment of COMPOSER: a rule-based approach to modelling protein structure. Biochemical Society Symposium. 57: 1-9. PMID 2099735  1
1990 McDonald NQ, Lapatto R, Murray-Rust J, Blundell TL. X-ray crystallographic studies on murine nerve growth factor. Journal of Cell Science. Supplement. 13: 19-30. PMID 2084116  1
1990 Overington J, Johnson MS, Sali A, Blundell TL. Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction. Proceedings. Biological Sciences / the Royal Society. 241: 132-45. PMID 1978340 DOI: 10.1098/rspb.1990.0077  1
1989 Cooper JB, Foundling SI, Blundell TL, Boger J, Jupp RA, Kay J. X-ray studies of aspartic proteinase-statine inhibitor complexes. Biochemistry. 28: 8596-603. PMID 2690945  1
1989 Lapatto R, Blundell T, Hemmings A, Overington J, Wilderspin A, Wood S, Merson JR, Whittle PJ, Danley DE, Geoghegan KF. X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes. Nature. 342: 299-302. PMID 2682266 DOI: 10.1038/342299a0  1
1989 Blundell TL, Elliott G, Gardner SP, Hubbard T, Islam S, Johnson M, Mantafounis D, Murray-Rust P, Overington J, Pitts JE. Protein engineering and design. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 324: 447-60. PMID 2573083  1
1989 Sibanda BL, Blundell TL, Thornton JM. Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering. Journal of Molecular Biology. 206: 759-77. PMID 2500530  0.52
1988 Blundell T, Carney D, Gardner S, Hayes F, Howlin B, Hubbard T, Overington J, Singh DA, Sibanda BL, Sutcliffe M. 18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design. European Journal of Biochemistry / Febs. 172: 513-20. PMID 3280310 DOI: 10.1111/J.1432-1033.1988.TB13917.X  1
1988 Thornton JM, Singh J, Campbell S, Blundell TL. Protein-protein recognition via side-chain interactions. Biochemical Society Transactions. 16: 927-30. PMID 3224756  0.52
1987 Blundell TL, Sibanda BL, Sternberg MJ, Thornton JM. Knowledge-based prediction of protein structures and the design of novel molecules. Nature. 326: 347-52. PMID 3550471 DOI: 10.1038/326347a0  0.52
1987 Jhoti H, McLeod AN, Blundell TL, Ishizaki H, Nagasawa H, Suzuki A. Prothoracicotropic hormone has an insulin-like tertiary structure Febs Letters. 219: 419-425. PMID 3301403 DOI: 10.1016/0014-5793(87)80264-8  1
1987 Foundling SI, Cooper J, Watson FE, Cleasby A, Pearl LH, Sibanda BL, Hemmings A, Wood SP, Blundell TL, Valler MJ, Norey CG, Kay J, Boger J, Dunn BM, Leckie BJ, et al. High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes Nature. 327: 349-352. PMID 3295561  1
1984 Glover ID, Barlow DJ, Pitts JE, Wood SP, Tickle IJ, Blundell TL, Tatemoto K, Kimmel JR, Wollmer A, Strassburger W. Conformational studies on the pancreatic polypeptide hormone family. European Journal of Biochemistry / Febs. 142: 379-85. PMID 6745282 DOI: 10.1111/J.1432-1033.1984.TB08298.X  1
1984 Travers P, Blundell TL, Sternberg MJ, Bodmer WF. Structural and evolutionary analysis of HLA-D-region products. Nature. 310: 235-8. PMID 6379465 DOI: 10.1038/310235A0  0.52
1982 Strassburger W, Glatter U, Wollmer A, Fleischhauer J, Mercola DA, Blundell TL, Glover I, Pitts JE, Tickle IJ, Wood SP. Calculated tyrosyl circular dichroism of proteins: absence of tryptophan and cystine interferences in avian pancreatic polypeptide. Febs Letters. 139: 295-9. PMID 7075780 DOI: 10.1016/0014-5793(82)80874-0  1
1980 Horuk R, Blundell TL, Lazarus NR, Neville RW, Stone D, Wollmer A. A monomeric insulin from the porcupine (Hystrix cristata), an Old World hystricomorph. Nature. 286: 822-4. PMID 6995860 DOI: 10.1038/286822a0  1
1977 Jenkins JA, Tickle IJ, Sewell T, Blundell TL. The structure at 0.3nm (3A) resolution of the acid proteinase from Endothia parasitica [proceedings] Biochemical Society Transactions. 5: 1120-1121. PMID 913799 DOI: 10.1042/BST0051120  1
1977 Jenkins J, Tickle I, Sewell T, Ungaretti L, Wollmer A, Blundell T. X-ray analysis and circular dichroism of the acid protease from Endothia parasitica and chymosin Advances in Experimental Medicine and Biology. 95: 43-60. PMID 339693 DOI: 10.1007/978-1-4757-0719-9_4  1
1975 Wood SP, Blundell TL, Wollmer A, Lazarus NR, Neville RW. The relation of conformation and association of insulin to receptor binding; x-ray and circular-dichroism studies on bovine and hystricomorph insulins. European Journal of Biochemistry / Febs. 55: 531-42. PMID 1175610 DOI: 10.1111/j.1432-1033.1975.tb02190.x  1
1972 Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA. Three-dimensional atomic structure of insulin and its relationship to activity. Diabetes. 21: 492-505. PMID 5054329 DOI: 10.2337/diab.21.2.S492  1
1972 Blundell TL, Cutfield JF, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA. The crystal structure of rhombohedral 2 zinc insulin. Cold Spring Harbor Symposia On Quantitative Biology. 36: 233-41. PMID 4508138 DOI: 10.1101/SQB.1972.036.01.031  1
1972 Blundell T, Dodson G, Hodgkin D, Mercola D. Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by Advances in Protein Chemistry. 26. DOI: 10.1016/S0065-3233(08)60143-6  1
1971 Blundell TL, Cutfield JF, Dodson GG, Dodson E, Hodgkin DC, Mercola D. The structure and biology of insulin. The Biochemical Journal. 125: 50P-51P. PMID 5169433 DOI: 10.1042/bj1250050P  1
1971 Blundell TL, Dodson GG, Dodson E, Hodgkin DC, Vijayan M. X-ray analysis and the structure of insulin Recent Progress in Hormone Research. 27: 1-40. PMID 4946130 DOI: 10.1016/B978-0-12-571127-2.50025-0  1
1971 Blundell TL, Cutfield JF, Cutfield SM, Dodson EJ, Dodson GG, Hodgkin DC, Mercola DA, Vijayan M. Atomic positions in rhombohedral 2-zinc insulin crystals. Nature. 231: 506-11. PMID 4932997 DOI: 10.1038/231506A0  1
1971 Blundell TL, Powell HM. Stereochemistry of cobalt complexes with heteronuclear metal-metal bonds: The crystal and molecular structure of tetracarbonyl(triphenylphosphineaurio) cobalt, and of tetracarbonyl{[bis-(o-dimethylarsinophenyl)methylarsine]argentio} cobalt Journal of the Chemical Society a: Inorganic, Physical, and Theoretical Chemistry. 1685-1690. DOI: 10.1039/J19710001685  1
1967 Blundell TL, Powell HM. The crystal and molecular structure of [Pd(TPAS)Cl]ClO3,C 6H6 [TPAS = o-phenylenebis-(o- dimethylarsinophenylmethylarsine)]: The stereochemistry of a pentaco-ordinate palladium complex ion Journal of the Chemical Society a: Inorganic, Physical, and Theoretical Chemistry. 1650-1657. DOI: 10.1039/J19670001650  1
1967 Blundell TL, Powell HM, Venanzi LM. A distorted trigonal bipyramidal co-ordination of cobalt in tris-(o-diphenylphosphinophenyl)phosphinochlorocobalt(II) tetraphenylborate Chemical Communications (London). 763-764. DOI: 10.1039/C19670000763  1
1967 Blundell TL, Powell HM. An unusual co-ordination of thallium in the crystal structure of dimethyl-1,10-phenanthrolinethallium perchlorate Chemical Communications (London). 54-55. DOI: 10.1039/C19670000054  1
1965 Kilbourn BT, Blundell TL, Powell HM. The molecular structures of bis-(o-dimethylarsinophenyl)methylarsinecopper- managanese pentacarbonyl, triphenylgermanium-manganese pentacarbonyl, and triphenylphosphinegold-cobalt tetracarbonyl Chemical Communications (London). 444-445. DOI: 10.1039/C19650000444  1
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