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Amy M. Barrios - Publications

Affiliations: 
Chemistry: Doctor of Philosophy University of Southern California, Los Angeles, CA, United States 
Area:
Inorganic Chemistry, Pharmaceutical Chemistry, Biochemistry
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wang H, Gaston R, Ahmed KT, Dudley GB, Barrios A. Derivatives of the Fungal Natural Product Illudalic Acid Inhibit the Activity of Protein Histidine Phosphatase PHPT1. Chemmedchem. e202300187. PMID 37267298 DOI: 10.1002/cmdc.202300187  0.369
2022 McCullough BS, Wang H, Barrios AM. Inhibitor Screen Identifies Covalent Inhibitors of the Protein Histidine Phosphatase PHPT1. Acs Medicinal Chemistry Letters. 13: 1198-1201. PMID 35859860 DOI: 10.1021/acsmedchemlett.2c00053  0.337
2020 Barrios AM. PTPs: Degrading the Undruggable. Journal of Medicinal Chemistry. PMID 32615037 DOI: 10.1021/Acs.Jmedchem.0C01000  0.414
2020 McCullough BS, Barrios AM. Fluorogenic probes for imaging cellular phosphatase activity. Current Opinion in Chemical Biology. 57: 34-40. PMID 32470893 DOI: 10.1016/J.Cbpa.2020.04.004  0.368
2020 McCullough BS, Barrios AM. In Vitro Assays for Measuring Protein Histidine Phosphatase Activity. Methods in Molecular Biology (Clifton, N.J.). 2077: 109-120. PMID 31707655 DOI: 10.1007/978-1-4939-9884-5_8  0.386
2019 McCullough BS, Batsomboon P, Hutchinson KB, Dudley GB, Barrios AM. Synthesis and PTP Inhibitory Activity of Illudalic Acid and Its Methyl Ether, with Insights into Selectivity for LAR PTP over Other Tyrosine Phosphatases under Physiologically Relevant Conditions. Journal of Natural Products. PMID 31809044 DOI: 10.1021/Acs.Jnatprod.9B00663  0.383
2019 Ma ES, Barrios AM. Rational design of a SHP-2 targeted, fluorogenic peptide substrate. Bioorganic & Medicinal Chemistry Letters. PMID 31351693 DOI: 10.1016/J.Bmcl.2019.07.034  0.326
2018 McCullough BS, Barrios AM. Facile, Fluorogenic Assay for Protein Histidine Phosphatase Activity. Biochemistry. PMID 29630837 DOI: 10.1021/Acs.Biochem.8B00278  0.302
2017 Biswas S, McCullough BS, Ma ES, LaJoie D, Russell CW, Garrett Brown D, Round JL, Ullman KS, Mulvey MA, Barrios AM. Dual colorimetric and fluorogenic probes for visualizing tyrosine phosphatase activity. Chemical Communications (Cambridge, England). PMID 28144650 DOI: 10.1039/C6Cc09204G  0.332
2015 Thorson MK, Van Wagoner RM, Harper MK, Ireland CM, Majtan T, Kraus JP, Barrios AM. Marine natural products as inhibitors of cystathionine beta-synthase activity. Bioorganic & Medicinal Chemistry Letters. 25: 1064-6. PMID 25666819 DOI: 10.1016/J.Bmcl.2015.01.013  0.354
2014 Thorson MK, Puerta DT, Cohen SM, Barrios AM. Inhibition of the lymphoid tyrosine phosphatase: the effect of zinc(II) ions and chelating ligand fragments on enzymatic activity. Bioorganic & Medicinal Chemistry Letters. 24: 4019-22. PMID 24997687 DOI: 10.1016/J.Bmcl.2014.06.016  0.445
2014 Ahmed VF, Bottini N, Barrios AM. Covalent inhibition of the lymphoid tyrosine phosphatase. Chemmedchem. 9: 296-9. PMID 24403103 DOI: 10.1002/Cmdc.201300404  0.453
2014 Sharlow ER, Leimgruber S, Murray S, Lira A, Sciotti RJ, Hickman M, Hudson T, Leed S, Caridha D, Barrios AM, Close D, Grögl M, Lazo JS. Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity. Acs Chemical Biology. 9: 663-72. PMID 24328400 DOI: 10.1021/Cb400800Q  0.401
2014 Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM. pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays. Methods (San Diego, Calif.). 65: 165-74. PMID 23886911 DOI: 10.1016/J.Ymeth.2013.07.022  0.35
2013 Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM. Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors. Chembiochem : a European Journal of Chemical Biology. 14: 1640-7. PMID 23956195 DOI: 10.1002/Cbic.201300273  0.501
2013 Kulkarni RA, Stanford SM, Vellore NA, Krishnamurthy D, Bliss MR, Baron R, Bottini N, Barrios AM. Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase. Chemmedchem. 8: 1561-8. PMID 23873737 DOI: 10.1002/Cmdc.201300215  0.425
2013 He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY. A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases. Journal of Medicinal Chemistry. 56: 4990-5008. PMID 23713581 DOI: 10.1021/Jm400248C  0.459
2013 Thorson MK, Majtan T, Kraus JP, Barrios AM. Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe. Angewandte Chemie (International Ed. in English). 52: 4641-4. PMID 23512751 DOI: 10.1002/Anie.201300841  0.364
2013 Qian Z, Liu T, Liu YY, Briesewitz R, Barrios AM, Jhiang SM, Pei D. Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs. Acs Chemical Biology. 8: 423-31. PMID 23130658 DOI: 10.1021/Cb3005275  0.328
2012 Stanford SM, Panchal RG, Walker LM, Wu DJ, Falk MD, Mitra S, Damle SS, Ruble D, Kaltcheva T, Zhang S, Zhang ZY, Bavari S, Barrios AM, Bottini N. High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45. Proceedings of the National Academy of Sciences of the United States of America. 109: 13972-7. PMID 22891353 DOI: 10.1073/Pnas.1205028109  0.633
2012 Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, et al. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine. 18: 956-60. PMID 22610278 DOI: 10.1038/Nm.2758  0.726
2012 Obiri DD, Flink N, Maier JV, Neeb A, Maddalo D, Thiele W, Menon A, Stassen M, Kulkarni RA, Garabedian MJ, Barrios AM, Cato ACB. PEST-domain-enriched tyrosine phosphatase and glucocorticoids as regulators of anaphylaxis in mice Allergy: European Journal of Allergy and Clinical Immunology. 67: 175-182. PMID 21981059 DOI: 10.1111/J.1398-9995.2011.02731.X  0.307
2011 Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry. 54: 1640-54. PMID 21341673 DOI: 10.1021/Jm101202J  0.456
2011 Karver CE, Ahmed VF, Barrios AM. Oxidative inactivation of the lymphoid tyrosine phosphatase mediated by both general and active site directed NO donors. Bioorganic & Medicinal Chemistry Letters. 21: 285-7. PMID 21129966 DOI: 10.1016/J.Bmcl.2010.11.025  0.335
2010 Karver MR, Krishnamurthy D, Bottini N, Barrios AM. Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase. Journal of Inorganic Biochemistry. 104: 268-73. PMID 20083307 DOI: 10.1016/J.Jinorgbio.2009.12.012  0.76
2009 Karver MR, Krishnamurthy D, Kulkarni RA, Bottini N, Barrios AM. Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes. Journal of Medicinal Chemistry. 52: 6912-8. PMID 19888762 DOI: 10.1021/Jm901220M  0.77
2009 Krishnamurthy D, Barrios AM. Profiling protein tyrosine phosphatase activity with mechanistic probes. Current Opinion in Chemical Biology. 13: 375-81. PMID 19716756 DOI: 10.1016/J.Cbpa.2009.07.017  0.34
2008 Karver MR, Barrios AM. Identifying and characterizing the biological targets of metallotherapeutics: Two approaches using Au(I)-protein interactions as model systems. Analytical Biochemistry. 382: 63-5. PMID 18692018 DOI: 10.1016/J.Ab.2008.07.019  0.742
2008 Krishnamurthy D, Karver MR, Fiorillo E, Orrú V, Stanford SM, Bottini N, Barrios AM. Gold(I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study. Journal of Medicinal Chemistry. 51: 4790-5. PMID 18605719 DOI: 10.1021/Jm800101W  0.773
2008 Franzman MA, Barrios AM. Spectroscopic evidence for the formation of goldfingers. Inorganic Chemistry. 47: 3928-30. PMID 18426199 DOI: 10.1021/Ic800157T  0.362
2008 Mitra S, Barrios AM. Identifying selective protein tyrosine phosphatase substrates and inhibitors from a fluorogenic, combinatorial peptide library. Chembiochem : a European Journal of Chemical Biology. 9: 1216-9. PMID 18412190 DOI: 10.1002/Cbic.200800046  0.612
2008 Gunatilleke SS, de Oliveira CA, McCammon JA, Barrios AM. Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 555-61. PMID 18253767 DOI: 10.1007/S00775-008-0344-0  0.773
2008 Hubbard CE, Barrios AM. A highly efficient route to enantiomerically pure l-N-Bz-Pmp(t-Bu)2-OH and incorporation into a peptide-based protein tyrosine phosphatase inhibitor. Bioorganic & Medicinal Chemistry Letters. 18: 679-81. PMID 18240386 DOI: 10.1016/J.Bmcl.2007.11.056  0.744
2008 Gunatilleke SS, Barrios AM. Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions. Journal of Inorganic Biochemistry. 102: 555-63. PMID 18164406 DOI: 10.1016/J.Jinorgbio.2007.10.019  0.757
2007 Mitra S, Barrios AM. A series of peptide-based, fluorogenic probes for protein tyrosine phosphatase activity. Analytical Biochemistry. 370: 249-51. PMID 17662953 DOI: 10.1016/J.Ab.2007.06.012  0.582
2006 Gunatilleke SS, Barrios AM. Inhibition of lysosomal cysteine proteases by a series of Au(I) complexes: a detailed mechanistic investigation. Journal of Medicinal Chemistry. 49: 3933-7. PMID 16789749 DOI: 10.1021/Jm060158F  0.776
2005 Mitra S, Barrios AM. Highly sensitive peptide-based probes for protein tyrosine phosphatase activity utilizing a fluorogenic mimic of phosphotyrosine. Bioorganic & Medicinal Chemistry Letters. 15: 5142-5. PMID 16203147 DOI: 10.1016/J.Bmcl.2005.08.054  0.569
2004 Chircorian A, Barrios AM. Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I). Bioorganic & Medicinal Chemistry Letters. 14: 5113-6. PMID 15380210 DOI: 10.1016/J.Bmcl.2004.07.073  0.499
2002 Barrios AM, Craik CS. Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence. Bioorganic & Medicinal Chemistry Letters. 12: 3619-23. PMID 12443789 DOI: 10.1016/S0960-894X(02)00786-2  0.361
2001 Barrios AM, Lippard SJ. Decomposition of alkyl-substituted urea molecules at a hydroxide-bridged dinickel center Inorganic Chemistry. 40: 1250-1255. PMID 11300826 DOI: 10.1021/Ic000933W  0.316
2001 Barrios AM, Lippard SJ. Phthalazine-based dinucleating ligands afford dinuclear centers often encountered in metalloenzyme active sites Inorganic Chemistry. 40: 1060-1064. PMID 11259020 DOI: 10.1021/Ic000889K  0.306
1998 LeCloux DD, Barrios AM, Mizoguchi TJ, Lippard SJ. Modeling the diiron centers of non-heme iron enzymes. Preparation of sterically hindered diiron(II) tetracarboxylate complexes and their reactions with dioxygen Journal of the American Chemical Society. 120: 9001-9014. DOI: 10.1021/Ja981216S  0.304
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