Lee Gehrke - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Microbiology Biology

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Vora SM, Fontana P, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M, Wang L, Iwasaki A, Wu H. Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35149555 DOI: 10.1073/pnas.2117198119  0.377
2020 Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, Li Z, Romorini L, Rodriguez Varela MS, Rothhammer V, Barroso A, Tjon EC, Sanmarco LM, Takenaka MC, Modaresi SMS, Gutiérrez-Vázquez C, ... ... Gehrke L, et al. AHR is a Zika virus host factor and a candidate target for antiviral therapy. Nature Neuroscience. PMID 32690969 DOI: 10.1038/S41593-020-0664-0  0.392
2020 Bosch I, Reddy A, de Puig H, Ludert JE, Perdomo-Celis F, Narváez CF, Versiani A, Fandos D, Nogueira ML, Singla M, Lodha R, Medigeshi GR, Lorenzana I, Ralde HV, Gélvez-Ramírez M, ... ... Gehrke L, et al. Serotype-specific detection of dengue viruses in a nonstructural protein 1-based enzyme-linked immunosorbent assay validated with a multi-national cohort. Plos Neglected Tropical Diseases. 14: e0008203. PMID 32579555 DOI: 10.1371/Journal.Pntd.0008203  0.329
2020 Basak A, Munschauer M, Lareau CA, Montbleau KE, Ulirsch JC, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, Wu X, Gehrke L, Rice CM, An X, Christou HA, et al. Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nature Genetics. PMID 31959994 DOI: 10.1038/S41588-019-0568-7  0.462
2019 Antonucci J, Gehrke L. Cerebral Organoid Models for Neurotropic Viruses. Acs Infectious Diseases. PMID 31580050 DOI: 10.1021/Acsinfecdis.9B00339  0.525
2019 Li Y, Muffat J, Omer Javed A, Keys HR, Lungjangwa T, Bosch I, Khan M, Virgilio MC, Gehrke L, Sabatini DM, Jaenisch R. Genome-wide CRISPR screen for Zika virus resistance in human neural cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31019072 DOI: 10.1073/Pnas.1900867116  0.306
2019 Metsky HC, Siddle KJ, Gladden-Young A, Qu J, Yang DK, Brehio P, Goldfarb A, Piantadosi A, Wohl S, Carter A, Lin AE, Barnes KG, Tully DC, Corleis B, Hennigan S, ... ... Gehrke L, et al. Capturing sequence diversity in metagenomes with comprehensive and scalable probe design. Nature Biotechnology. 37: 160-168. PMID 30718881 DOI: 10.1038/S41587-018-0006-X  0.311
2019 Ocwieja K, Stanton A, Richards A, Antonucci J, Hughes T, Shalek A, Jaenisch R, Gehrke L. 973. Single-cell RNA Sequencing Analysis of Zika Virus Infection in Human Stem Cell-Derived Cerebral Organoids Open Forum Infectious Diseases. 6: S33-S34. DOI: 10.1093/Ofid/Ofz359.075  0.436
2018 Myhrvold C, Freije CA, Gootenberg JS, Abudayyeh OO, Metsky HC, Durbin AF, Kellner MJ, Tan AL, Paul LM, Parham LA, Garcia KF, Barnes KG, Chak B, Mondini A, Nogueira ML, ... ... Gehrke L, et al. Field-deployable viral diagnostics using CRISPR-Cas13. Science (New York, N.Y.). 360: 444-448. PMID 29700266 DOI: 10.1126/Science.Aas8836  0.335
2018 Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK, Abdulhay NJ, Specht H, Keshishian H, Mani DR, Jovanovic M, Ellis SR, Fulco CP, Engreitz JM, Schütz S, ... ... Gehrke L, et al. Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis. Cell. PMID 29551269 DOI: 10.1016/J.Cell.2018.02.036  0.313
2018 Basak A, Munschauer M, Ulirsch JC, Montbleau KE, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, Wu X, Gehrke L, Rice CM, An X, Christou HA, Narla M, et al. Control of Human Hemoglobin Switching By LIN28B-Mediated Regulation of BCL11A Translation Blood. 132: 412-412. DOI: 10.1182/Blood-2018-99-117440  0.444
2017 Bosch I, de Puig H, Hiley M, Carré-Camps M, Perdomo-Celis F, Narváez CF, Salgado DM, Senthoor D, O'Grady M, Phillips E, Durbin A, Fandos D, Miyazaki H, Yen CW, Gélvez-Ramírez M, ... ... Gehrke L, et al. Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum. Science Translational Medicine. 9. PMID 28954927 DOI: 10.1126/Scitranslmed.Aan1589  0.351
2017 Metsky HC, Matranga CB, Wohl S, Schaffner SF, Freije CA, Winnicki SM, West K, Qu J, Baniecki ML, Gladden-Young A, Lin AE, Tomkins-Tinch CH, Ye SH, Park DJ, Luo CY, ... ... Gehrke L, et al. Zika virus evolution and spread in the Americas. Nature. PMID 28538734 DOI: 10.1038/Nature22402  0.36
2016 Durbin AF, Wang C, Marcotrigiano J, Gehrke L. RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling. Mbio. 7. PMID 27651356 DOI: 10.1128/Mbio.00833-16  0.638
2016 Pardee K, Green AA, Takahashi MK, Braff D, Lambert G, Lee JW, Ferrante T, Ma D, Donghia N, Fan M, Daringer NM, Bosch I, Dudley DM, O'Connor DH, Gehrke L, et al. Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components. Cell. PMID 27160350 DOI: 10.1016/J.Cell.2016.04.059  0.504
2013 Pickett BE, Liu M, Sadat EL, Squires RB, Noronha JM, He S, Jen W, Zaremba S, Gu Z, Zhou L, Larsen CN, Bosch I, Gehrke L, McGee M, Klem EB, et al. Metadata-driven comparative analysis tool for sequences (meta-CATS): an automated process for identifying significant sequence variations that correlate with virus attributes. Virology. 447: 45-51. PMID 24210098 DOI: 10.1016/J.Virol.2013.08.021  0.342
2011 Schmidt DJ, Pickett BE, Camacho D, Comach G, Xhaja K, Lennon NJ, Rizzolo K, de Bosch N, Becerra A, Nogueira ML, Mondini A, da Silva EV, Vasconcelos PF, Muñoz-Jordán JL, Santiago GA, ... ... Gehrke L, et al. A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 11: 2011-9. PMID 21964598 DOI: 10.1016/J.Meegid.2011.09.010  0.361
2011 Gomila RC, Martin GW, Gehrke L. NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication. Plos One. 6: e16687. PMID 21386893 DOI: 10.1371/Journal.Pone.0016687  0.841
2009 Simon AE, Gehrke L. RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs. Biochimica Et Biophysica Acta. 1789: 571-83. PMID 19501200 DOI: 10.1016/J.Bbagrm.2009.05.005  0.698
2009 Uzri D, Gehrke L. Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. Journal of Virology. 83: 4174-84. PMID 19224987 DOI: 10.1128/Jvi.02449-08  0.81
2008 Gomila RC, Gehrke L. Biochemical approaches for characterizing RNA-protein complexes in preparation for high resolution structure analysis. Methods in Molecular Biology (Clifton, N.J.). 451: 279-91. PMID 18370263 DOI: 10.1007/978-1-59745-102-4_20  0.837
2007 Reichert VL, Choi M, Petrillo JE, Gehrke L. Alfalfa mosaic virus coat protein bridges RNA and RNA-dependent RNA polymerase in vitro. Virology. 364: 214-26. PMID 17400272 DOI: 10.1016/J.Virol.2007.02.026  0.853
2006 Boyce M, Scott F, Guogas LM, Gehrke L. Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex. Journal of Molecular Recognition : Jmr. 19: 68-78. PMID 16312015 DOI: 10.1002/Jmr.759  0.847
2005 Guogas LM, Laforest SM, Gehrke L. Coat protein activation of alfalfa mosaic virus replication is concentration dependent. Journal of Virology. 79: 5752-61. PMID 15827190 DOI: 10.1128/Jvi.79.9.5752-5761.2005  0.836
2005 Petrillo JE, Rocheleau G, Kelley-Clarke B, Gehrke L. Evaluation of the conformational switch model for alfalfa mosaic virus RNA replication. Journal of Virology. 79: 5743-51. PMID 15827189 DOI: 10.1128/Jvi.79.9.5743-5751.2005  0.841
2004 Guogas LM, Filman DJ, Hogle JM, Gehrke L. Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication. Science (New York, N.Y.). 306: 2108-11. PMID 15604410 DOI: 10.1126/Science.1103399  0.847
2004 Rocheleau G, Petrillo J, Guogas L, Gehrke L. Degenerate in vitro genetic selection reveals mutations that diminish alfalfa mosaic virus RNA replication without affecting coat protein binding. Journal of Virology. 78: 8036-46. PMID 15254175 DOI: 10.1128/Jvi.78.15.8036-8046.2004  0.776
2004 Laforest SM, Gehrke L. Spatial determinants of the alfalfa mosaic virus coat protein binding site. Rna (New York, N.Y.). 10: 48-58. PMID 14681584 DOI: 10.1261/Rna.5154104  0.74
2004 Guogas L, Hogle J, Gehrke L. Origins of Life and the RNA World: Evolution of RNA-Replicase Recognition Symposium - International Astronomical Union. 213: 321-324. DOI: 10.1017/s0074180900193489  0.639
2001 Tumer NE, Kaniewski W, Haley L, Gehrke L, Lodge JK, Sanders P. The second amino acid of alfalfa mosaic virus coat protein is critical for coat protein-mediated protection. Proceedings of the National Academy of Sciences of the United States of America. 88: 2331-5. PMID 11607167 DOI: 10.1073/Pnas.88.6.2331  0.589
1998 Ansel-Mckinney P, Gehrke L. RNA determinants of a specific RNA-coat protein peptide interaction in alfalfa mosaic virus: Conservation of homologous features in ilarvirus RNAs Journal of Molecular Biology. 278: 767-785. PMID 9614941 DOI: 10.1006/Jmbi.1998.1656  0.769
1998 Swanson MM, Ansel-McKinney P, Houser-Scott F, Yusibov V, Loesch-Fries LS, Gehrke L. Viral coat protein peptides with limited sequence homology bind similar domains of alfalfa mosaic virus and tobacco streak virus RNAs. Journal of Virology. 72: 3227-34. PMID 9525649 DOI: 10.1128/Jvi.72.4.3227-3234.1998  0.743
1997 MacBeth KJ, Ro YT, Gehrke L, Patterson JL. Cleavage site mapping and substrate-specificity of Leishmaniavirus 2-1 capsid endoribonuclease activity. Journal of Biochemistry. 122: 193-200. PMID 9276688 DOI: 10.1093/Oxfordjournals.Jbchem.A021728  0.648
1997 Hann LE, Webb AC, Cai JM, Gehrke L. Identification of a competitive translation determinant in the 3' untranslated region of alfalfa mosaic virus coat protein mRNA Molecular and Cellular Biology. 17: 2005-2013. PMID 9121448 DOI: 10.1128/Mcb.17.4.2005  0.723
1997 Houser-Scott F, Ansel-McKinney P, Cai JM, Gehrke L. In vitro genetic selection analysis of alfalfa mosaic virus coat protein binding to 3'-terminal AUGC repeats in the viral RNAs Journal of Virology. 71: 2310-2319. PMID 9032367 DOI: 10.1128/Jvi.71.3.2310-2319.1997  0.733
1996 Ansel-McKinney P, Scott SW, Swanson M, Ge X, Gehrke L. A plant viral coat protein RNA binding consensus sequence contains a crucial arginine. The Embo Journal. 15: 5077-84. PMID 8890181 DOI: 10.1002/J.1460-2075.1996.Tb00888.X  0.731
1995 Hann LE, Gehrke L. mRNAs containing the unstructured 5′ leader sequence of alfalfa mosaic virus RNA 4 translate inefficiently in lysates from poliovirus-infected HeLa cells Journal of Virology. 69: 4986-4993. PMID 7609069 DOI: 10.1128/Jvi.69.8.4986-4993.1995  0.607
1994 Baer ML, Houser F, Loesch-Fries LS, Gehrke L. Specific RNA binding by amino-terminal peptides of alfalfa mosaic virus coat protein. The Embo Journal. 13: 727-35. PMID 8313916 DOI: 10.1002/J.1460-2075.1994.Tb06312.X  0.739
1994 Houser-Scott F, Baer ML, Liem KF, Cai JM, Gehrke L. Nucleotide sequence and structural determinants of specific binding of coat protein or coat protein peptides to the 3' untranslated region of alfalfa mosaic virus RNA 4. Journal of Virology. 68: 2194-205. PMID 8139004 DOI: 10.1128/Jvi.68.4.2194-2205.1994  0.679
1994 Gehrke L, Hann LE, Kaspar RL. Chapter 25. Translational Control of Gene Expression Annual Reports in Medicinal Chemistry. 29: 245-254. DOI: 10.1016/S0065-7743(08)60738-1  0.583
1991 Chen JJ, Throop MS, Gehrke L, Kuo I, Pal JK, Brodsky M, London IM. Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase. Proceedings of the National Academy of Sciences of the United States of America. 88: 7729-33. PMID 1679235 DOI: 10.1073/Pnas.88.17.7729  0.363
1991 Tumer NGE, Kaniewski W, Haley L, Gehrke L, Lodge JK, Sanders P. The second amino acid of alfalfa mosaic virus coat protein is critical for coat protein-mediated protection Proceedings of the National Academy of Sciences of the United States of America. 88: 2331-2335.  0.512
1988 Jobling SA, Cuthbert CM, Rogers SG, Fraley RT, Gehrke L. In vitro transcription and translational efficiency of chimeric SP6 messenger RNAs devoid of 5′ vector nucleotides Nucleic Acids Research. 16: 4483-4498. PMID 3260027 DOI: 10.1093/Nar/16.10.4483  0.588
1987 Jobling SA, Gehrke L. Enhanced translation of chimaeric messenger RNAs containing a plant viral untranslated leader sequence Nature. 325: 622-625. PMID 3492677 DOI: 10.1038/325622A0  0.603
1986 Gehrke L. Preparation of mRNA transcripts for secondary structure analysis using SP6 polymerase, guanylyltransferase, and preparative gel electrophoresis Gene Analysis Techniques. 3: 45-52. DOI: 10.1016/0735-0651(86)90005-1  0.491
1984 Quigley GJ, Gehrke L, Roth DA, Auron PE. Computer-aided nucleic acid secondary structure modeling incorporating enzymatic digestion data Nucleic Acids Research. 12: 347-366. PMID 6320093 DOI: 10.1093/Nar/12.1Part1.347  0.506
1983 Gehrke L, Ilan J. Preferential utilization of exogenously supplied leucine for protein synthesis in estradiol-induced and uninduced cockerel liver explants Proceedings of the National Academy of Sciences of the United States of America. 80: 3274-3278. PMID 6574484 DOI: 10.1073/Pnas.80.11.3274  0.305
1983 Gehrke L, Auron PE, Quigley GJ, Rich A, Sonenberg N. 5′-Conformation of capped alfalfa mosaic virus ribonucleic acid 4 may reflect its independence of the cap structure or of cap-binding protein for efficient translation Biochemistry. 22: 5157-5164. PMID 6317016 DOI: 10.1021/Bi00291A015  0.601
1977 Bast RE, Garfield SA, Gehrke L, Ilan J. Coordination of ribosome content and polysome formation during estradiol stimulation of vitellogenin synthesis in immature male chick livers. Proceedings of the National Academy of Sciences of the United States of America. 74: 3133-7. PMID 269377 DOI: 10.1073/Pnas.74.8.3133  0.306
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