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Michela Ottolia, PhD - Publications

Affiliations: 
Physiology University of California, Los Angeles, Los Angeles, CA 
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y. Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1. Nature Communications. 14: 6181. PMID 37794011 DOI: 10.1038/s41467-023-41885-4  0.444
2021 Ottolia M, John S, Hazan A, Goldhaber JI. The Cardiac Na -Ca Exchanger: From Structure to Function. Comprehensive Physiology. 12: 2681-2717. PMID 34964124 DOI: 10.1002/cphy.c200031  0.407
2021 Angelini M, Pezhouman A, Savalli N, Chang MG, Steccanella F, Scranton K, Calmettes G, Ottolia M, Pantazis A, Karagueuzian HS, Weiss JN, Olcese R. Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current. The Journal of General Physiology. 153. PMID 34698805 DOI: 10.1085/jgp.202012584  0.337
2021 Lotteau S, Zhang R, Hazan A, Grabar C, Gonzalez D, Aynaszyan S, Philipson KD, Ottolia M, Goldhaber JI. Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia. Journal of the American Heart Association. e019273. PMID 34472363 DOI: 10.1161/JAHA.120.019273  0.419
2020 Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI. Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling. Cell Calcium. 87: 102167. PMID 32028091 DOI: 10.1016/J.Ceca.2020.102167  0.452
2020 Zyrianova T, Lopez B, Liao A, Gu C, Wong L, Ottolia M, Olcese R, Schwingshackl A. Large Conductance Ca2+-activated K+ Channels Regulate LPS-induced Cytokine Secretion from Alveolar Epithelial and Endothelial Cells Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.997  0.47
2020 Scranton K, Umar S, Calmettes G, Eghbali M, Goldhaber JI, John SA, Olcese R, Escobar AL, Ottolia M. The Na+-dependent Inactivation of NCX1.1 is Physiologically Relevant to Cardiac Function Biophysical Journal. 118: 100a-101a. DOI: 10.1016/J.Bpj.2019.11.707  0.354
2020 Steccanella F, Scranton K, Panday N, Angelini M, Zhang R, Lotteau S, John SA, Olcese R, Goldhaber JI, Ottolia M. Genetic Ablation of NCX1.1 Na+-dependent Inactivation Impacts Cardiac Action Potential and Ca2+ Transient Biophysical Journal. 118: 100a. DOI: 10.1016/J.Bpj.2019.11.706  0.469
2019 Scranton K, John S, Escobar A, Goldhaber JI, Ottolia M. Modulation of the cardiac Na-Ca exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications. Cell Calcium. 87: 102140. PMID 32070924 DOI: 10.1016/J.Ceca.2019.102140  0.541
2018 John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. Molecular determinants of pH regulation in the cardiac Na+-Ca2+ exchanger. The Journal of General Physiology. PMID 29301861 DOI: 10.1085/Jgp.201611693  0.496
2017 John S, Kim B, Olcese R, Goldhaber JI, Ottolia M. Proton Sensitivity of NCX: Modulation by Na, Ca and a Distinct Proton-Sensing Domain Biophysical Journal. 112: 275a. DOI: 10.1016/J.Bpj.2016.11.1488  0.489
2015 Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, et al. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. The Journal of Physiology. 593: 1361-82. PMID 25772291 DOI: 10.1113/Jphysiol.2014.282319  0.486
2014 Ottolia M, John S, Goldhaber JI. Four Histidines Account for the Inhibitory Effect of Protons on the Cardiac Na+-Ca2+ Exchanger Biophysical Journal. 106: 581a. DOI: 10.1016/J.Bpj.2013.11.3223  0.509
2013 Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. Na/Ca exchange and contraction of the heart. Journal of Molecular and Cellular Cardiology. 61: 28-33. PMID 23770352 DOI: 10.1016/J.Yjmcc.2013.06.001  0.517
2013 John SA, Liao J, Jiang Y, Ottolia M. The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. Proceedings of the National Academy of Sciences of the United States of America. 110: 7500-5. PMID 23589872 DOI: 10.1073/Pnas.1218751110  0.505
2013 Ottolia M, Philipson KD. NCX1: mechanism of transport. Advances in Experimental Medicine and Biology. 961: 49-54. PMID 23224869 DOI: 10.1007/978-1-4614-4756-6_5  0.509
2013 Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD. 20 years from NCX purification and cloning: milestones. Advances in Experimental Medicine and Biology. 961: 17-23. PMID 23224866 DOI: 10.1007/978-1-4614-4756-6_2  0.471
2012 Boctor N, John S, Philipson KD, Ottolia M. The Affinity of the Cardiac Na+-Ca2+ Exchanger to Regulatory Ca2+ is Decreased by Cytoplasmic Mg2+ Biophysical Journal. 102: 662a. DOI: 10.1016/J.Bpj.2011.11.3606  0.52
2012 Bridge JHB, Torres NS, Ottolia M. Na +-Ca 2+ Exchange Currents Cell Physiology Source Book. 195-219. DOI: 10.1016/B978-0-12-387738-3.00014-7  0.429
2011 John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proceedings of the National Academy of Sciences of the United States of America. 108: 1699-704. PMID 21209335 DOI: 10.1073/Pnas.1016114108  0.515
2011 Ottolia M, Nicoll DA, Philipson KD. The Cytoplasmic Ion Permeation Pathway of the Cardiac Na+-Ca2+ Exchanger Biophysical Journal. 100: 244a. DOI: 10.1016/J.Bpj.2010.12.1552  0.514
2010 Ottolia M, Nicoll DA, John S, Philipson KD. Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation. Channels (Austin, Tex.). 4: 159-62. PMID 20224291 DOI: 10.4161/Chan.4.3.11386  0.525
2010 Ottolia M, Ribalet B, Scott J, Philipson KD. Ca2+-Induced Conformational Changes of Na+-Ca2+ Exchanger Dimers: Role of Ca2+ Binding Domains Biophysical Journal. 98: 683a. DOI: 10.1016/J.Bpj.2009.12.3754  0.513
2010 Ottolia M, Nicoll DA, John S, Philipson KD. Interactions between Ca2+ binding domains of the Na +-Ca2+ exchanger and secondary regulation Channels. 4.  0.415
2009 Ottolia M, Nicoll DA, Philipson KD. Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger. The Journal of Biological Chemistry. 284: 32735-41. PMID 19801651 DOI: 10.1074/Jbc.M109.055434  0.516
2009 Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger. The Journal of Biological Chemistry. 284: 14688-92. PMID 19332552 DOI: 10.1074/Jbc.C900037200  0.518
2009 Ottolia M, Nicoll DA, Philipson KD. Roles of Calcium Binding Domains 1 and 2 in Ca2+ Regulation of the Na+-Ca2+ exchanger Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.3619  0.523
2008 Xie Y, Ottolia M, John SA, Chen JN, Philipson KD. Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart. American Journal of Physiology. Cell Physiology. 295: C388-93. PMID 18550703 DOI: 10.1152/Ajpcell.00178.2008  0.522
2008 Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. The RCK2 domain of the human BKCa channel is a calcium sensor. Proceedings of the National Academy of Sciences of the United States of America. 105: 376-81. PMID 18162557 DOI: 10.1073/Pnas.0705261105  0.577
2007 Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin, Tex.). 1: 397-9. PMID 18690047 DOI: 10.4161/Chan.1.6.5640  0.525
2007 Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proceedings of the National Academy of Sciences of the United States of America. 104: 18467-72. PMID 17962412 DOI: 10.1073/Pnas.0707417104  0.523
2007 Ottolia M, John S, Xie Y, Ren X, Philipson KD. Shedding light on the Na+/Ca2+ exchanger. Annals of the New York Academy of Sciences. 1099: 78-85. PMID 17446447 DOI: 10.1196/Annals.1387.044  0.522
2007 Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. What we know about the structure of NCX1 and how it relates to its function. Annals of the New York Academy of Sciences. 1099: 1-6. PMID 17303833 DOI: 10.1196/Annals.1387.014  0.446
2007 Ottolia M, Philipson KD, John S. Xenopus oocyte plasma membrane sheets for FRET analysis. American Journal of Physiology. Cell Physiology. 292: C1519-22. PMID 17166939 DOI: 10.1152/Ajpcell.00435.2006  0.351
2007 Ottolia M, John S, Ren X, Philipson KD. Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization. The Journal of Biological Chemistry. 282: 3695-701. PMID 17158867 DOI: 10.1074/Jbc.M610425200  0.489
2005 Ottolia M, Nicoll DA, Philipson KD. Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger. The Journal of Biological Chemistry. 280: 1061-9. PMID 15519995 DOI: 10.1074/Jbc.M411899200  0.445
2004 Ottolia M, Philipson KD, John S. Conformational changes of the Ca(2+) regulatory site of the Na(+)-Ca(2+) exchanger detected by FRET. Biophysical Journal. 87: 899-906. PMID 15298897 DOI: 10.1529/Biophysj.104.043471  0.536
2002 Ottolia M, Schumann S, Nicoll DA, Philipson KD. Activation of the cardiac Na+/Ca2+ exchanger by DEPC. Annals of the New York Academy of Sciences. 976: 85-8. PMID 12502540 DOI: 10.1111/J.1749-6632.2002.Tb04720.X  0.496
2002 Nicoll DA, Ottolia M, Philipson KD. Toward a topological model of the NCX1 exchanger. Annals of the New York Academy of Sciences. 976: 11-8. PMID 12502529 DOI: 10.1111/J.1749-6632.2002.Tb04709.X  0.353
2002 Philipson KD, Nicoll DA, Ottolia M, Quednau BD, Reuter H, John S, Qiu Z. The Na+/Ca2+ exchange molecule: an overview. Annals of the New York Academy of Sciences. 976: 1-10. PMID 12502528 DOI: 10.1111/J.1749-6632.2002.Tb04708.X  0.482
2001 Ottolia M, John S, Qiu Z, Philipson KD. Split Na+-Ca2+ exchangers. Implications for function and expression. The Journal of Biological Chemistry. 276: 19603-9. PMID 11274218 DOI: 10.1074/Jbc.M101489200  0.416
2000 Santacruz-Toloza L, Ottolia M, Nicoll DA, Philipson KD. Functional analysis of a disulfide bond in the cardiac Na(+)-Ca(2+) exchanger. The Journal of Biological Chemistry. 275: 182-8. PMID 10617603 DOI: 10.1074/Jbc.275.1.182  0.436
1999 Groh S, Marty I, Ottolia M, Prestipino G, Chapel A, Villaz M, Ronjat M. Functional interaction of the cytoplasmic domain of triadin with the skeletal ryanodine receptor. The Journal of Biological Chemistry. 274: 12278-83. PMID 10212196 DOI: 10.1074/Jbc.274.18.12278  0.504
1999 Ottolia M, Babini E, Gazzotti P, Possani LD, Prestipino G. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum. Brain Research. 815: 410-3. PMID 9878856 DOI: 10.1016/S0006-8993(98)01165-2  0.506
1999 Nicoll DA, Ottolia M, Lu L, Lu Y, Philipson KD. A new topological model of the cardiac sarcolemmal Na+-Ca2+ exchanger. The Journal of Biological Chemistry. 274: 910-7. PMID 9873031 DOI: 10.1074/Jbc.274.2.910  0.456
1998 Ottolia M, Platano D, Qin N, Noceti F, Birnbaumer M, Toro L, Birnbaumer L, Stefani E, Olcese R. Functional coupling between human E-type Ca2+ channels and mu opioid receptors expressed in Xenopus oocytes. Febs Letters. 427: 96-102. PMID 9613607 DOI: 10.1016/S0014-5793(98)00401-3  0.624
1998 Pisciotta M, Ottolia M, Possani LD, Prestipino G. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes. Biochemical and Biophysical Research Communications. 242: 287-91. PMID 9446786 DOI: 10.1006/Bbrc.1997.7929  0.457
1997 Treves S, Scutari E, Robert M, Groh S, Ottolia M, Prestipino G, Ronjat M, Zorzato F. Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. Biochemistry. 36: 11496-503. PMID 9298970 DOI: 10.1021/Bi970160W  0.491
1997 Stefani E, Ottolia M, Noceti F, Olcese R, Wallner M, Latorre R, Toro L. Voltage-controlled gating in a large conductance Ca2+-sensitive K+channel (hslo). Proceedings of the National Academy of Sciences of the United States of America. 94: 5427-31. PMID 9144254 DOI: 10.1073/Pnas.94.10.5427  0.669
1996 Ottolia M, Toro L. Reconstitution in lipid bilayers of an ATP-sensitive K+ channel from pig coronary smooth muscle. The Journal of Membrane Biology. 153: 203-9. PMID 8849415 DOI: 10.1007/S002329900123  0.579
1995 Wallner M, Meera P, Ottolia M, Kaczorowski GJ, Latorre R, Garcia ML, Stefani E, Toro L. Characterization of and modulation by a beta-subunit of a human maxi KCa channel cloned from myometrium. Receptors & Channels. 3: 185-99. PMID 8821792  0.647
1994 Toro L, Ottolia M, Stefani E, Latorre R. Structural determinants in the interaction of Shaker inactivating peptide and a Ca(2+)-activated K+ channel. Biochemistry. 33: 7220-8. PMID 8003487 DOI: 10.1021/Bi00189A026  0.651
1994 Ottolia M, Toro L. Potentiation of large conductance KCa channels by niflumic, flufenamic, and mefenamic acids. Biophysical Journal. 67: 2272-9. PMID 7535111 DOI: 10.1016/S0006-3495(94)80712-X  0.579
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