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Tina M. Cairns, Ph.D. - Publications

Affiliations: 
2000 Pennsylvania State University, State College, PA, United States 
Area:
Microbiology Biology, Molecular Biology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Atanasiu D, Saw WT, Cairns TM, Friedman HM, Eisenberg RJ, Cohen GH. Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion. Viruses. 15. PMID 37112875 DOI: 10.3390/v15040895  0.416
2022 Gandy LA, Canning AJ, Lou H, Xia K, He P, Su G, Cairns T, Liu J, Zhang F, Linhardt RJ, Cohen G, Wang C. Molecular determinants of the interaction between HSV-1 glycoprotein D and heparan sulfate. Frontiers in Molecular Biosciences. 9: 1043713. PMID 36419932 DOI: 10.3389/fmolb.2022.1043713  0.365
2021 Atanasiu D, Saw WT, Cairns TM, Eisenberg RJ, Cohen GH. Using Split Luciferase Assay and anti-HSV Glycoprotein Monoclonal Antibodies to Predict a Functional Binding Site Between gD and gH/gL. Journal of Virology. PMID 33504603 DOI: 10.1128/JVI.00053-21  0.489
2020 Brooks BD, Closmore A, Yang J, Holland M, Cairns T, Cohen GH, Bailey-Kellogg C. Characterizing Epitope Binding Regions of Entire Antibody Panels by Combining Experimental and Computational Analysis of Antibody: Antigen Binding Competition. Molecules (Basel, Switzerland). 25. PMID 32796656 DOI: 10.3390/Molecules25163659  0.373
2020 Cairns TM, Connolly SA. Entry of Alphaherpesviruses. Current Issues in Molecular Biology. 41: 63-124. PMID 32764159 DOI: 10.21775/Cimb.041.063  0.524
2020 Cairns TM, Atanasiu D, Saw WT, Lou H, Whitbeck JC, Ditto NT, Bruun B, Browne H, Bennett L, Wu C, Krummenacher C, Brooks BD, Eisenberg RJ, Cohen GH. Localization of the interaction site of herpes simplex virus glycoprotein D (gD) on the membrane fusion regulator, gH/gL. Journal of Virology. PMID 32759318 DOI: 10.1128/Jvi.00983-20  0.536
2020 Tuzmen C, Cairns TM, Atanasiu D, Lou H, Saw WT, Hall BL, Cohen JB, Cohen GH, Glorioso JC. Point Mutations in Retargeted gD Eliminate the Sensitivity of EGFR/EGFRvIII-Targeted HSV to Key Neutralizing Antibodies. Molecular Therapy. Methods & Clinical Development. 16: 145-154. PMID 32042851 DOI: 10.1016/J.Omtm.2019.12.013  0.552
2019 Awasthi S, Hook LM, Swaminathan G, Cairns TM, Brooks B, Smith JS, Ditto NT, Gindy ME, Bett AJ, Espeseth AS, Cohen GH, Friedman HM. Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants. Vaccine. PMID 31153687 DOI: 10.1016/J.Vaccine.2019.05.068  0.419
2019 Cairns TM, Ditto NT, Atanasiu D, Lou H, Brooks BD, Saw WT, Eisenberg RJ, Cohen GH. Surface plasmon resonance (SPR) reveals direct binding of HSV glycoproteins gH/gL to gD and locates a gH/gL binding site on gD. Journal of Virology. PMID 31092568 DOI: 10.1128/Jvi.00289-19  0.477
2018 Atanasiu D, Saw WT, Lazear E, Whitbeck JC, Cairns TM, Lou H, Eisenberg RJ, Cohen GH. Using antibodies and mutants to localize the presumptive gH/gL binding site on HSV gD. Journal of Virology. PMID 30282715 DOI: 10.1128/Jvi.01694-18  0.568
2018 Hook LM, Cairns TM, Awasthi S, Brooks BD, Ditto NT, Eisenberg RJ, Cohen GH, Friedman HM. Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs. Plos Pathogens. 14: e1007095. PMID 29791513 DOI: 10.1371/Journal.Ppat.1007095  0.457
2017 Cairns TM, Ditto NT, Lou H, Brooks BD, Atanasiu D, Eisenberg RJ, Cohen GH. Global sensing of the antigenic structure of herpes simplex virus gD using high-throughput array-based SPR imaging. Plos Pathogens. 13: e1006430. PMID 28614387 DOI: 10.1371/Journal.Ppat.1006430  0.438
2016 Persson J, Zhang Y, Olafsdottir TA, Thörn K, Cairns TM, Wegmann F, Sattentau QJ, Eisenberg RJ, Cohen GH, Harandi AM. Nasal Immunization Confers High Avidity Neutralizing Antibody Response and Immunity to Primary and Recurrent Genital Herpes in Guinea Pigs. Frontiers in Immunology. 7: 640. PMID 28082979 DOI: 10.3389/Fimmu.2016.00640  0.365
2015 Cairns TM, Huang ZY, Gallagher JR, Lin Y, Lou H, Whitbeck JC, Wald A, Cohen GH, Eisenberg RJ. Patient-specific neutralizing antibody responses to herpes simplex virus are attributed to epitopes on either gD, gB, or both and can be type-specific. Journal of Virology. PMID 26109729 DOI: 10.1128/Jvi.01213-15  0.517
2014 Cairns TM, Huang ZY, Whitbeck JC, Ponce de Leon M, Lou H, Wald A, Krummenacher C, Eisenberg RJ, Cohen GH. Dissection of the antibody response against herpes simplex virus glycoproteins in naturally infected humans. Journal of Virology. 88: 12612-22. PMID 25142599 DOI: 10.1128/Jvi.01930-14  0.494
2014 Whitbeck JC, Huang ZY, Cairns TM, Gallagher JR, Lou H, Ponce-de-Leon M, Belshe RB, Eisenberg RJ, Cohen GH. Repertoire of epitopes recognized by serum IgG from humans vaccinated with herpes simplex virus 2 glycoprotein D. Journal of Virology. 88: 7786-95. PMID 24789783 DOI: 10.1128/Jvi.00544-14  0.446
2014 Cairns TM, Fontana J, Huang ZY, Whitbeck JC, Atanasiu D, Rao S, Shelly SS, Lou H, Ponce de Leon M, Steven AC, Eisenberg RJ, Cohen GH. Mechanism of neutralization of herpes simplex virus by antibodies directed at the fusion domain of glycoprotein B. Journal of Virology. 88: 2677-89. PMID 24352457 DOI: 10.1128/Jvi.03200-13  0.515
2013 Maurer UE, Zeev-Ben-Mordehai T, Pandurangan AP, Cairns TM, Hannah BP, Whitbeck JC, Eisenberg RJ, Cohen GH, Topf M, Huiskonen JT, Grünewald K. The structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction. Structure (London, England : 1993). 21: 1396-405. PMID 23850455 DOI: 10.1016/J.Str.2013.05.018  0.353
2013 Atanasiu D, Cairns TM, Whitbeck JC, Saw WT, Rao S, Eisenberg RJ, Cohen GH. Regulation of herpes simplex virus gB-induced cell-cell fusion by mutant forms of gH/gL in the absence of gD and cellular receptors. Mbio. 4. PMID 23443004 DOI: 10.1128/Mbio.00046-13  0.572
2012 Shelly SS, Cairns TM, Whitbeck JC, Lou H, Krummenacher C, Cohen GH, Eisenberg RJ. The membrane-proximal region (MPR) of herpes simplex virus gB regulates association of the fusion loops with lipid membranes. Mbio. 3. PMID 23170000 DOI: 10.1128/Mbio.00429-12  0.529
2012 Eisenberg RJ, Atanasiu D, Cairns TM, Gallagher JR, Krummenacher C, Cohen GH. Herpes virus fusion and entry: a story with many characters. Viruses. 4: 800-32. PMID 22754650 DOI: 10.3390/V4050800  0.531
2012 Lazear E, Whitbeck JC, Ponce-de-Leon M, Cairns TM, Willis SH, Zuo Y, Krummenacher C, Cohen GH, Eisenberg RJ. Antibody-induced conformational changes in herpes simplex virus glycoprotein gD reveal new targets for virus neutralization. Journal of Virology. 86: 1563-76. PMID 22130533 DOI: 10.1128/Jvi.06480-11  0.504
2011 Eisenberg RJ, Cairns TM, Cohen GH. HCMV grabs a mechanism to escape neutralization. Cell Host & Microbe. 10: 177-8. PMID 21925104 DOI: 10.1016/J.Chom.2011.08.011  0.354
2011 Cairns TM, Whitbeck JC, Lou H, Heldwein EE, Chowdary TK, Eisenberg RJ, Cohen GH. Capturing the herpes simplex virus core fusion complex (gB-gH/gL) in an acidic environment. Journal of Virology. 85: 6175-84. PMID 21507973 DOI: 10.1128/Jvi.00119-11  0.508
2010 Chowdary TK, Cairns TM, Atanasiu D, Cohen GH, Eisenberg RJ, Heldwein EE. Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL. Nature Structural & Molecular Biology. 17: 882-8. PMID 20601960 DOI: 10.1038/Nsmb.1837  0.526
2010 Silverman JL, Sharma S, Cairns TM, Heldwein EE. Fusion-deficient insertion mutants of herpes simplex virus type 1 glycoprotein B adopt the trimeric postfusion conformation. Journal of Virology. 84: 2001-12. PMID 19939928 DOI: 10.1128/Jvi.01791-09  0.512
2009 Hannah BP, Cairns TM, Bender FC, Whitbeck JC, Lou H, Eisenberg RJ, Cohen GH. Herpes simplex virus glycoprotein B associates with target membranes via its fusion loops. Journal of Virology. 83: 6825-36. PMID 19369321 DOI: 10.1128/Jvi.00301-09  0.591
2008 Lazear E, Carfi A, Whitbeck JC, Cairns TM, Krummenacher C, Cohen GH, Eisenberg RJ. Engineered disulfide bonds in herpes simplex virus type 1 gD separate receptor binding from fusion initiation and viral entry. Journal of Virology. 82: 700-9. PMID 18032483 DOI: 10.1128/Jvi.02192-07  0.478
2007 Atanasiu D, Whitbeck JC, Cairns TM, Reilly B, Cohen GH, Eisenberg RJ. Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion. Proceedings of the National Academy of Sciences of the United States of America. 104: 18718-23. PMID 18003913 DOI: 10.1073/Pnas.0707452104  0.49
2007 Scheifele LZ, Kenney SP, Cairns TM, Craven RC, Parent LJ. Overlapping roles of the Rous sarcoma virus Gag p10 domain in nuclear export and virion core morphology. Journal of Virology. 81: 10718-28. PMID 17634229 DOI: 10.1128/Jvi.01061-07  0.646
2007 Cairns TM, Friedman LS, Lou H, Whitbeck JC, Shaner MS, Cohen GH, Eisenberg RJ. N-terminal mutants of herpes simplex virus type 2 gH are transported without gL but require gL for function. Journal of Virology. 81: 5102-11. PMID 17344290 DOI: 10.1128/Jvi.00097-07  0.439
2006 Cairns TM, Shaner MS, Zuo Y, Ponce-de-Leon M, Baribaud I, Eisenberg RJ, Cohen GH, Whitbeck JC. Epitope mapping of herpes simplex virus type 2 gH/gL defines distinct antigenic sites, including some associated with biological function. Journal of Virology. 80: 2596-608. PMID 16501070 DOI: 10.1128/Jvi.80.6.2596-2608.2006  0.524
2005 Cairns TM, Landsburg DJ, Whitbeck JC, Eisenberg RJ, Cohen GH. Contribution of cysteine residues to the structure and function of herpes simplex virus gH/gL. Virology. 332: 550-62. PMID 15680420 DOI: 10.1016/J.Virol.2004.12.006  0.435
2003 Cairns TM, Milne RS, Ponce-de-Leon M, Tobin DK, Cohen GH, Eisenberg RJ. Structure-function analysis of herpes simplex virus type 1 gD and gH-gL: clues from gDgH chimeras. Journal of Virology. 77: 6731-42. PMID 12767993 DOI: 10.1128/Jvi.77.12.6731-6742.2003  0.578
2001 Cairns TM, Craven RC. Viral DNA synthesis defects in assembly-competent Rous sarcoma virus CA mutants. Journal of Virology. 75: 242-50. PMID 11119594 DOI: 10.1128/Jvi.75.1.242-250.2001  0.648
2000 Parent LJ, Cairns TM, Albert JA, Wilson CB, Wills JW, Craven RC. RNA dimerization defect in a Rous sarcoma virus matrix mutant. Journal of Virology. 74: 164-72. PMID 10590103 DOI: 10.1128/Jvi.74.1.164-172.2000  0.659
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