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Keefe T. Chan, Ph.D. - Publications

Affiliations: 
2010 University of Wisconsin, Madison, Madison, WI 
Area:
Cell Biology
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dietrich C, Trub A, Ahn A, Taylor M, Ambani K, Chan KT, Lu KH, Mahendra CA, Blyth C, Coulson R, Ramm S, Watt AC, Matsa SK, Bisi J, Strum J, et al. INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors. Cancer Discovery. PMID 38047585 DOI: 10.1158/2159-8290.CD-23-0954  0.358
2022 Zhu H, Chan KT, Huang X, Cerra C, Blake S, Trigos AS, Anderson D, Creek DJ, De Souza DP, Wang X, Fu C, Jana M, Sanij E, Pearson RB, Kang J. Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation. Elife. 11. PMID 35758651 DOI: 10.7554/eLife.71929  0.311
2020 Kusnadi EP, Trigos AS, Cullinane C, Goode DL, Larsson O, Devlin JR, Chan KT, De Souza DP, McConville MJ, McArthur GA, Thomas G, Sanij E, Poortinga G, Hannan RD, Hannan KM, et al. Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis. The Embo Journal. e105111. PMID 32945574 DOI: 10.15252/Embj.2020105111  0.346
2020 Zhu H, Blake S, Kusuma FK, Pearson RB, Kang J, Chan KT. Oncogene-Induced Senescence: from Biology to Therapy. Mechanisms of Ageing and Development. 111229. PMID 32171687 DOI: 10.1016/J.Mad.2020.111229  0.416
2019 AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, et al. Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 31439820 DOI: 10.1073/Pnas.1901323116  0.424
2019 Chan KT, Blake S, Zhu H, Kang J, Trigos AS, Madhamshettiwar PB, Diesch J, Paavolainen L, Horvath P, Hannan RD, George AJ, Sanij E, Hannan KM, Simpson KJ, Pearson RB. A functional genetic screen defines the AKT-induced senescence signaling network. Cell Death and Differentiation. PMID 31285545 DOI: 10.1038/S41418-019-0384-8  0.417
2018 Zhu H, Blake S, Chan KT, Pearson RB, Kang J. Cystathionine -Synthase in Physiology and Cancer. Biomed Research International. 2018: 3205125. PMID 30050925 DOI: 10.1155/2018/3205125  0.368
2017 Yan S, Frank D, Son J, Hannan KM, Hannan RD, Chan KT, Pearson RB, Sanij E. The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer. International Journal of Molecular Sciences. 18. PMID 28117679 DOI: 10.3390/Ijms18010210  0.346
2017 Yan S, Chan KT, Simpson KJ, Sanij E, Sheppard KE, Hannan KM, Hannan RD, Pearson RB. Abstract A24: A genome-wide RNAi screen identifies synthetic lethality of CX-5461 with homologous recombination repair deficiency in ovarian cancer Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-A24  0.411
2016 Chan KT, Paavolainen L, Hannan KM, George AJ, Hannan RD, Simpson KJ, Horvath P, Pearson RB. Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence. Assay and Drug Development Technologies. 14: 416-428. PMID 27552145 DOI: 10.1089/Adt.2016.739  0.441
2016 Quin J, Chan KT, Devlin JR, Cameron DP, Diesch J, Cullinane C, Ahern J, Khot A, Hein N, George AJ, Hannan KM, Poortinga G, Sheppard KE, Khanna KK, Johnstone RW, et al. Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling. Oncotarget. PMID 27391441 DOI: 10.18632/Oncotarget.10452  0.36
2015 Creed SJ, Le CP, Hassan M, Pon CK, Albold S, Chan KT, Berginski ME, Huang Z, Bear JE, Lane JR, Halls ML, Ferrari D, Nowell CJ, Sloan EK. β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion. Breast Cancer Research : Bcr. 17: 145. PMID 26607426 DOI: 10.1186/S13058-015-0655-3  0.453
2015 Carson CC, Moschos SJ, Edmiston SN, Darr DB, Nikolaishvili-Feinberg N, Groben PA, Zhou X, Kuan PF, Pandey S, Chan KT, Jordan JL, Hao H, Frank JS, Hopkinson DA, Gibbs DC, et al. IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2167-76. PMID 25934889 DOI: 10.1158/1078-0432.Ccr-14-1826  0.334
2014 Chan KT, Asokan SB, King SJ, Bo T, Dubose ES, Liu W, Berginski ME, Simon JM, Davis IJ, Gomez SM, Sharpless NE, Bear JE. LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues. The Journal of Cell Biology. 207: 299-315. PMID 25349262 DOI: 10.1083/Jcb.201404067  0.452
2013 Chan KT, Asokan SB, Bo T, Berginski ME, Liu W, Cochran SD, Sharpless NE, Bear JE. Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-C14  0.41
2013 Debebe Z, Porter M, Hull-Ryde EE, Rasmussen N, Sendor A, Norris-Drouin J, Chan K, Bear JE, Janzen WP, Rathmell K. Abstract B206: Ror2 as a therapeutic target in renal cell carcinoma and other invasive cancers. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B206  0.48
2012 Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, Chan KT, Roadcap DW, Ollila DW, Thomas NE, Castrillon DH, Miller CR, Perou CM, Wong KK, Bear JE, Sharpless NE. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell. 21: 751-64. PMID 22698401 DOI: 10.1016/J.Ccr.2012.03.048  0.321
2012 Chan KT, Roadcap DW, Holoweckyj N, Bear JE. Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. The Biochemical Journal. 444: 89-96. PMID 22364218 DOI: 10.1042/Bj20120209  0.31
2011 Chan KT, Creed SJ, Bear JE. Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends in Cell Biology. 21: 481-8. PMID 21632254 DOI: 10.1016/J.Tcb.2011.04.004  0.408
2010 Chan KT, Bennin DA, Huttenlocher A. Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK). The Journal of Biological Chemistry. 285: 11418-26. PMID 20150423 DOI: 10.1074/Jbc.M109.090746  0.68
2010 Chan KT, Bennin DA, Huttenlocher A. Regulation of adhesion dynamics by calpain-mediated proteolysis of FAK F1000research. 1. DOI: 10.7490/F1000Research.41.1  0.635
2009 Chan KT, Cortesio CL, Huttenlocher A. FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. The Journal of Cell Biology. 185: 357-70. PMID 19364917 DOI: 10.1083/Jcb.200809110  0.771
2008 Cortesio CL, Chan KT, Perrin BJ, Burton NO, Zhang S, Zhang ZY, Huttenlocher A. Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. The Journal of Cell Biology. 180: 957-71. PMID 18332219 DOI: 10.1083/Jcb.200708048  0.69
2008 Cortesio CL, Chan KT, Huttenlocher A. Adhesion Dynamics in Motile Cells Cell Junctions: Adhesion, Development, and Disease. 71-88. DOI: 10.1002/9783527622092.ch4  0.736
2007 Lokuta MA, Senetar MA, Bennin DA, Nuzzi PA, Chan KT, Ott VL, Huttenlocher A. Type Igamma PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis. Molecular Biology of the Cell. 18: 5069-80. PMID 17928408 DOI: 10.1091/Mbc.E07-05-0428  0.699
2007 Chan KT, Cortesio CL, Huttenlocher A. Integrins in cell migration. Methods in Enzymology. 426: 47-67. PMID 17697879 DOI: 10.1016/S0076-6879(07)26003-3  0.755
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