Bernhard O. Palsson, PhD - Publications

1984-1995 Chemical Engineering University of Michigan, Ann Arbor, Ann Arbor, MI 
 1995- Bioengineering University of California, San Diego, La Jolla, CA 

489 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Rajput A, Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Lamsa A, Seif Y, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Knight R, ... ... Palsson BO, et al. Profiling the effect of nafcillin on HA-MRSA D712 using bacteriological and physiological media. Scientific Data. 6: 322. PMID 31848353 DOI: 10.1038/s41597-019-0331-z  1
2019 Anand A, Chen K, Yang L, Sastry AV, Olson CA, Poudel S, Seif Y, Hefner Y, Phaneuf PV, Xu S, Szubin R, Feist AM, Palsson BO. Adaptive evolution reveals a tradeoff between growth rate and oxidative stress during naphthoquinone-based aerobic respiration. Proceedings of the National Academy of Sciences of the United States of America. PMID 31767748 DOI: 10.1073/pnas.1909987116  1
2019 Nogales J, Mueller J, Gudmundsson S, Canalejo FJ, Duque E, Monk J, Feist AM, Ramos JL, Niu W, Palsson BO. High-quality genome-scale metabolic modeling of Pseudomonas putida highlights its broad metabolic capabilities. Environmental Microbiology. PMID 31657101 DOI: 10.1111/1462-2920.14843  1
2019 Anand A, Chen K, Catoiu E, Sastry AV, Olson CA, Sandberg TE, Seif Y, Xu S, Szubin R, Yang L, Feist AM, Palsson BO. OxyR is a convergent target for mutations acquired during adaptation to oxidative stress-prone metabolic states. Molecular Biology and Evolution. PMID 31651953 DOI: 10.1093/molbev/msz251  1
2019 Du B, Olson CA, Sastry AV, Fang X, Phaneuf PV, Chen K, Wu M, Szubin R, Xu S, Gao Y, Hefner Y, Feist AM, Palsson BO. Adaptive laboratory evolution of under acid stress. Microbiology (Reading, England). PMID 31625833 DOI: 10.1099/mic.0.000867  1
2019 Machado H, Weng LL, Dillon N, Seif Y, Holland M, Pekar JE, Monk JM, Nizet V, Palsson BO, Feist AM. A defined minimal medium for systems analyses of reveals strain-specific metabolic requirements. Applied and Environmental Microbiology. PMID 31471305 DOI: 10.1128/AEM.01773-19  1
2019 Sandberg TE, Salazar MJ, Weng LL, Palsson BO, Feist AM. The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology. Metabolic Engineering. PMID 31401242 DOI: 10.1016/j.ymben.2019.08.004  1
2019 Yang L, Mih N, Anand A, Park JH, Tan J, Yurkovich JT, Monk JM, Lloyd CJ, Sandberg TE, Seo SW, Kim D, Sastry AV, Phaneuf P, Gao Y, Broddrick JT, ... ... Palsson BO, et al. Cellular responses to reactive oxygen species are predicted from molecular mechanisms. Proceedings of the National Academy of Sciences of the United States of America. PMID 31270234 DOI: 10.1073/pnas.1905039116  1
2019 Cheng C, O'Brien EJ, McCloskey D, Utrilla J, Olson C, LaCroix RA, Sandberg TE, Feist AM, Palsson BO, King ZA. Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism. Plos Computational Biology. 15: e1007066. PMID 31158228 DOI: 10.1371/journal.pcbi.1007066  1
2019 Yang JH, Wright SN, Hamblin M, McCloskey D, Alcantar MA, Schrübbers L, Lopatkin AJ, Satish S, Nili A, Palsson BO, Walker GC, Collins JJ. A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action. Cell. PMID 31080069 DOI: 10.1016/j.cell.2019.04.016  1
2019 Poudel S, Tsunemoto H, Meehan M, Szubin R, Olson CA, Lamsa A, Seif Y, Dillon N, Vrbanac A, Sugie J, Dahesh S, Monk JM, Dorrestein PC, Pogliano J, Knight R, ... ... Palsson BO, et al. Characterization of CA-MRSA TCH1516 exposed to nafcillin in bacteriological and physiological media. Scientific Data. 6: 43. PMID 31028276 DOI: 10.1038/s41597-019-0051-4  1
2019 Lachance JC, Lloyd CJ, Monk JM, Yang L, Sastry AV, Seif Y, Palsson BO, Rodrigue S, Feist AM, King ZA, Jacques PÉ. BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data. Plos Computational Biology. 15: e1006971. PMID 31009451 DOI: 10.1371/journal.pcbi.1006971  1
2019 Guzmán GI, Sandberg TE, LaCroix RA, Nyerges Á, Papp H, de Raad M, King ZA, Hefner Y, Northen TR, Notebaart RA, Pál C, Palsson BO, Papp B, Feist AM. Enzyme promiscuity shapes adaptation to novel growth substrates. Molecular Systems Biology. 15: e8462. PMID 30962359 DOI: 10.15252/msb.20188462  1
2019 Luo H, Hansen ASL, Yang L, Schneider K, Kristensen M, Christensen U, Christensen HB, Du B, Özdemir E, Feist AM, Keasling JD, Jensen MK, Herrgård MJ, Palsson BO. Coupling S-adenosylmethionine-dependent methylation to growth: Design and uses. Plos Biology. 17: e2007050. PMID 30856169 DOI: 10.1371/journal.pbio.2007050  1
2019 Heirendt L, Arreckx S, Pfau T, Mendoza SN, Richelle A, Heinken A, Haraldsdóttir HS, Wachowiak J, Keating SM, Vlasov V, Magnusdóttir S, Ng CY, Preciat G, Žagare A, Chan SHJ, ... ... Palsson BØ, et al. Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0. Nature Protocols. PMID 30787451 DOI: 10.1038/s41596-018-0098-2  1
2019 Anand A, Olson CA, Yang L, Sastry AV, Catoiu E, Choudhary KS, Phaneuf PV, Sandberg TE, Xu S, Hefner Y, Szubin R, Feist AM, Palsson BO. Pseudogene repair driven by selection pressure applied in experimental evolution. Nature Microbiology. PMID 30692668 DOI: 10.1038/s41564-018-0340-2  1
2018 Guzmán GI, Olson CA, Hefner Y, Phaneuf PV, Catoiu E, Crepaldi LB, Micas LG, Palsson BO, Feist AM. Reframing gene essentiality in terms of adaptive flexibility. Bmc Systems Biology. 12: 143. PMID 30558585 DOI: 10.1186/s12918-018-0653-z  1
2018 Dinh HV, King ZA, Palsson BO, Feist AM. Identification of growth-coupled production strains considering protein costs and kinetic variability. Metabolic Engineering Communications. 7: e00080. PMID 30370222 DOI: 10.1016/j.mec.2018.e00080  1
2018 Phaneuf PV, Gosting D, Palsson BO, Feist AM. ALEdb 1.0: a database of mutations from adaptive laboratory evolution experimentation. Nucleic Acids Research. PMID 30357390 DOI: 10.1093/nar/gky983  1
2018 McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. Evolution of gene knockout strains of E. coli reveal regulatory architectures governed by metabolism. Nature Communications. 9: 3796. PMID 30228271 DOI: 10.1038/s41467-018-06219-9  1
2018 McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. Growth Adaptation of and Deletion Strains Diverges From a Similar Initial Perturbation of the Transcriptome. Frontiers in Microbiology. 9: 1793. PMID 30131786 DOI: 10.3389/fmicb.2018.01793  1
2018 McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. Multiple optimal phenotypes overcome redox and glycolytic intermediate metabolite imbalances in knockout evolutions. Applied and Environmental Microbiology. PMID 30054360 DOI: 10.1128/AEM.00823-18  1
2018 McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. Adaptive laboratory evolution resolves energy depletion to maintain high aromatic metabolite phenotypes in Escherichia coli strains lacking the Phosphotransferase System. Metabolic Engineering. PMID 29906504 DOI: 10.1016/j.ymben.2018.06.005  1
2018 McCloskey D, Xu S, Sandberg TE, Brunk E, Hefner Y, Szubin R, Feist AM, Palsson BO. Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes. Metabolic Engineering. PMID 29842925 DOI: 10.1016/j.ymben.2018.05.012  1
2018 Latif H, Federowicz S, Ebrahim A, Tarasova J, Szubin R, Utrilla J, Zengler K, Palsson BO. ChIP-exo interrogation of Crp, DNA, and RNAP holoenzyme interactions. Plos One. 13: e0197272. PMID 29771928 DOI: 10.1371/journal.pone.0197272  1
2018 Norsigian CJ, Kavvas E, Seif Y, Palsson BO, Monk JM. iCN718, an Updated and Improved Genome-Scale Metabolic Network Reconstruction of AYE. Frontiers in Genetics. 9: 121. PMID 29692801 DOI: 10.3389/fgene.2018.00121  0.92
2018 Cho S, Choe D, Lee E, Kim SC, Palsson BØ, Cho BK. High-level dCas9 expression induces abnormal cell morphology in Escherichia coli. Acs Synthetic Biology. PMID 29544049 DOI: 10.1021/acssynbio.7b00462  0.92
2018 Yurkovich JT, Bordbar A, Sigurjónsson ÓE, Palsson BO. Systems biology as an emerging paradigm in transfusion medicine. Bmc Systems Biology. 12: 31. PMID 29514691 DOI: 10.1186/s12918-018-0558-x  1
2018 Kavvas ES, Seif Y, Yurkovich JT, Norsigian C, Poudel S, Greenwald WW, Ghatak S, Palsson BO, Monk JM. Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions. Bmc Systems Biology. 12: 25. PMID 29499714 DOI: 10.1186/s12918-018-0557-y  1
2018 Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Dräger A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlić A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, ... ... Palsson BO, et al. Recon3D enables a three-dimensional view of gene variation in human metabolism. Nature Biotechnology. PMID 29457794 DOI: 10.1038/nbt.4072  1
2018 Mih N, Brunk E, Chen K, Catoiu E, Sastry A, Kavvas E, Monk JM, Zhang Z, Palsson BO, Valencia A. ssbio: A Python Framework for Structural Systems Biology. Bioinformatics (Oxford, England). PMID 29444205 DOI: 10.1093/bioinformatics/bty077  1
2018 Yurkovich JT, Palsson BO. Quantitative -omic data empowers bottom-up systems biology. Current Opinion in Biotechnology. 51: 130-136. PMID 29414439 DOI: 10.1016/j.copbio.2018.01.009  0.8
2018 Kim D, Seo SW, Gao Y, Nam H, Guzman GI, Cho BK, Palsson BO. Systems assessment of transcriptional regulation on central carbon metabolism by Cra and CRP. Nucleic Acids Research. PMID 29394395 DOI: 10.1093/nar/gky069  0.92
2018 Yang L, Yurkovich JT, King ZA, Palsson BO. Modeling the multi-scale mechanisms of macromolecular resource allocation. Current Opinion in Microbiology. 45: 8-15. PMID 29367175 DOI: 10.1016/j.mib.2018.01.002  0.92
2018 Abdel-Haleem AM, Hefzi H, Mineta K, Gao X, Gojobori T, Palsson BO, Lewis NE, Jamshidi N. Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting. Plos Computational Biology. 14: e1005895. PMID 29300748 DOI: 10.1371/journal.pcbi.1005895  1
2017 Nilsson A, Nielsen J, Palsson BO. Metabolic Models of Protein Allocation Call for the Kinetome. Cell Systems. 5: 538-541. PMID 29284126 DOI: 10.1016/j.cels.2017.11.013  0.56
2017 Du B, Zielinski DC, Palsson BO. Topological and kinetic determinants of the modal matrices of dynamic models of metabolism. Plos One. 12: e0189880. PMID 29267329 DOI: 10.1371/journal.pone.0189880  1
2017 Long CP, Gonzalez JE, Feist AM, Palsson BO, Antoniewicz MR. Dissecting the genetic and metabolic mechanisms of adaptation to the knockout of a major metabolic enzyme in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. PMID 29255023 DOI: 10.1073/pnas.1716056115  1
2017 Yang JH, Bhargava P, McCloskey D, Mao N, Palsson BO, Collins JJ. Antibiotic-Induced Changes to the Host Metabolic Environment Inhibit Drug Efficacy and Alter Immune Function. Cell Host & Microbe. 22: 757-765.e3. PMID 29199098 DOI: 10.1016/j.chom.2017.10.020  1
2017 Chen K, Gao Y, Mih N, O'Brien EJ, Yang L, Palsson BO. Thermosensitivity of growth is determined by chaperone-mediated proteome reallocation. Proceedings of the National Academy of Sciences of the United States of America. 114: 11548-11553. PMID 29073085 DOI: 10.1073/pnas.1705524114  1
2017 Yurkovich JT, Zielinski DC, Yang L, Paglia G, Rolfsson O, Sigurjónsson ÓE, Broddrick JT, Bordbar A, Wichuk K, Brynjólfsson S, Palsson S, Gudmundsson S, Palsson BO. Quantitative time-course metabolomics in human red blood cells reveal the temperature dependence of human metabolic networks. The Journal of Biological Chemistry. PMID 29030425 DOI: 10.1074/jbc.M117.804914  1
2017 Monk JM, Lloyd CJ, Brunk E, Mih N, Sastry A, King Z, Takeuchi R, Nomura W, Zhang Z, Mori H, Feist AM, Palsson BO. iML1515, a knowledgebase that computes Escherichia coli traits. Nature Biotechnology. 35: 904-908. PMID 29020004 DOI: 10.1038/nbt.3956  1
2017 Yurkovich JT, Yurkovich BJ, Dräger A, Palsson BO, King ZA. A Padawan Programmer's Guide to Developing Software Libraries. Cell Systems. PMID 28988801 DOI: 10.1016/j.cels.2017.08.003  1
2017 Long CP, Gonzalez JE, Feist AM, Palsson BO, Antoniewicz MR. Fast growth phenotype of E. coli K-12 from adaptive laboratory evolution does not require intracellular flux rewiring. Metabolic Engineering. PMID 28951266 DOI: 10.1016/j.ymben.2017.09.012  1
2017 Fang X, Sastry A, Mih N, Kim D, Tan J, Yurkovich JT, Lloyd CJ, Gao Y, Yang L, Palsson BO. Global transcriptional regulatory network for Escherichia coli robustly connects gene expression to transcription factor activities. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874552 DOI: 10.1073/pnas.1702581114  1
2017 Seo SW, Gao Y, Kim D, Szubin R, Yang J, Cho BK, Palsson BO. Revealing genome-scale transcriptional regulatory landscape of OmpR highlights its expanded regulatory roles under osmotic stress in Escherichia coli K-12 MG1655. Scientific Reports. 7: 2181. PMID 28526842 DOI: 10.1038/s41598-017-02110-7  0.92
2017 Sandberg TE, Lloyd CJ, Palsson BO, Feist AM. Laboratory Evolution to Alternating Substrate Environments Yields Distinct Phenotypic and Genetic Adaptive Strategies. Applied and Environmental Microbiology. PMID 28455337 DOI: 10.1128/AEM.00410-17  1
2017 Sastry A, Monk J, Tegel H, Uhlén M, Palsson BO, Rockberg J, Brunk E. Machine Learning in Computational Biology to Accelerate High-Throughput Protein Expression. Bioinformatics (Oxford, England). PMID 28398465 DOI: 10.1093/bioinformatics/btx207  1
2017 Bordbar A, Yurkovich JT, Paglia G, Rolfsson O, Sigurjónsson ÓE, Palsson BO. Elucidating dynamic metabolic physiology through network integration of quantitative time-course metabolomics. Scientific Reports. 7: 46249. PMID 28387366 DOI: 10.1038/srep46249  1
2017 Yurkovich JT, Yang L, Palsson BO. Biomarkers are used to predict quantitative metabolite concentration profiles in human red blood cells. Plos Computational Biology. 13: e1005424. PMID 28264007 DOI: 10.1371/journal.pcbi.1005424  0.8
2017 Levering J, Dupont CL, Allen AE, Palsson BO, Zengler K. Integrated Regulatory and Metabolic Networks of the Marine Diatom Phaeodactylum tricornutum Predict the Response to Rising CO2 Levels. Msystems. 2. PMID 28217746 DOI: 10.1128/mSystems.00142-16  1
2017 LaCroix RA, Palsson BO, Feist AM. A Model for Designing Adaptive Laboratory Evolution Experiments. Applied and Environmental Microbiology. PMID 28159796 DOI: 10.1128/AEM.03115-16  1
2017 Zielinski DC, Jamshidi N, Corbett AJ, Bordbar A, Thomas A, Palsson BO. Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. Scientific Reports. 7: 41241. PMID 28120890 DOI: 10.1038/srep41241  1
2017 Ma D, Yang L, Fleming RM, Thiele I, Palsson BO, Saunders MA. Reliable and efficient solution of genome-scale models of Metabolism and macromolecular Expression. Scientific Reports. 7: 40863. PMID 28098205 DOI: 10.1038/srep40863  1
2017 van Wijk XM, Döhrmann S, Hallström BM, Li S, Voldborg BG, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD. Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion. Mbio. 8. PMID 28074024 DOI: 10.1128/mBio.02128-16  1
2017 Aziz RK, Monk JM, Andrews KA, Nhan J, Khaw VL, Wong H, Palsson BO, Charusanti P. The aldehyde dehydrogenase, AldA, is essential for L-1,2-propanediol utilization in laboratory-evolved Escherichia coli. Microbiological Research. 194: 47-52. PMID 27938862 DOI: 10.1016/j.micres.2016.10.006  0.92
2016 King ZA, O'Brien EJ, Feist AM, Palsson BO. Literature mining supports a next-generation modeling approach to predict cellular byproduct secretion. Metabolic Engineering. PMID 27986597 DOI: 10.1016/j.ymben.2016.12.004  1
2016 Broddrick JT, Rubin BE, Welkie DG, Du N, Mih N, Diamond S, Lee JJ, Golden SS, Palsson BO. Unique attributes of cyanobacterial metabolism revealed by improved genome-scale metabolic modeling and essential gene analysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911809 DOI: 10.1073/pnas.1613446113  1
2016 Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, ... ... Palsson BO, et al. A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism. Cell Systems. 3: 434-443.e8. PMID 27883890 DOI: 10.1016/j.cels.2016.10.020  1
2016 Yang L, Yurkovich JT, Lloyd CJ, Ebrahim A, Saunders MA, Palsson BO. Principles of proteome allocation are revealed using proteomic data and genome-scale models. Scientific Reports. 6: 36734. PMID 27857205 DOI: 10.1038/srep36734  0.96
2016 D'Alessandro A, Nemkov T, Yoshida T, Bordbar A, Palsson BO, Hansen KC. Citrate metabolism in red blood cells stored in additive solution-3. Transfusion. PMID 27813142 DOI: 10.1111/trf.13892  1
2016 Ebrahim A, Brunk E, Tan J, O'Brien EJ, Kim D, Szubin R, Lerman JA, Lechner A, Sastry A, Bordbar A, Feist AM, Palsson BO. Multi-omic data integration enables discovery of hidden biological regularities. Nature Communications. 7: 13091. PMID 27782110 DOI: 10.1038/ncomms13091  1
2016 Monk JM, Koza A, Campodonico MA, Machado D, Seoane JM, Palsson BO, Herrgård MJ, Feist AM. Multi-omics Quantification of Species Variation of Escherichia coli Links Molecular Features with Strain Phenotypes. Cell Systems. PMID 27667363 DOI: 10.1016/j.cels.2016.08.013  1
2016 Yang L, Ma D, Ebrahim A, Lloyd CJ, Saunders MA, Palsson BO. solveME: fast and reliable solution of nonlinear ME models. Bmc Bioinformatics. 17: 391. PMID 27659412 DOI: 10.1186/s12859-016-1240-1  0.96
2016 Paglia G, D'Alessandro A, Rolfsson Ó, Sigurjónsson ÓE, Bordbar A, Palsson S, Nemkov T, Hansen KC, Gudmundsson S, Palsson BO. Biomarkers defining the metabolic age of red blood cells during cold storage. Blood. PMID 27554084 DOI: 10.1182/blood-2016-06-721688  1
2016 Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, ... ... Palsson BØ, et al. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nature Biotechnology. 34: 828-837. PMID 27504778 DOI: 10.1038/nbt.3597  0.72
2016 Paglia G, Sigurjónsson ÓE, Bordbar A, Rolfsson Ó, Magnusdottir M, Palsson S, Wichuk K, Gudmundsson S, Palsson BO. Metabolic fate of adenine in red blood cells during storage in SAGM solution. Transfusion. PMID 27491795 DOI: 10.1111/trf.13740  1
2016 Mih N, Brunk E, Bordbar A, Palsson BO. A Multi-scale Computational Platform to Mechanistically Assess the Effect of Genetic Variation on Drug Responses in Human Erythrocyte Metabolism. Plos Computational Biology. 12: e1005039. PMID 27467583 DOI: 10.1371/journal.pcbi.1005039  1
2016 Liu HC, Jamshidi N, Chen Y, Eraly SA, Cho SY, Bhatnagar V, Wu W, Bush KT, Abagyan R, Palsson BO, Nigam SK. Construction and Evaluation of an Organic Anion Transporter 1 (OAT1)-Centered Metabolic Network. The Journal of Biological Chemistry. PMID 27440044 DOI: 10.1074/jbc.M116.745216  1
2016 O'Brien EJ, Utrilla J, Palsson BO. Quantification and Classification of E. coli Proteome Utilization and Unused Protein Costs across Environments. Plos Computational Biology. 12: e1004998. PMID 27351952 DOI: 10.1371/journal.pcbi.1004998  1
2016 Bosi E, Monk JM, Aziz RK, Fondi M, Nizet V, Palsson BØ. Comparative genome-scale modelling of Staphylococcus aureus strains identifies strain-specific metabolic capabilities linked to pathogenicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27286824 DOI: 10.1073/pnas.1523199113  1
2016 Du B, Zielinski DC, Kavvas ES, Dräger A, Tan J, Zhang Z, Ruggiero KE, Arzumanyan GA, Palsson BO. Evaluation of rate law approximations in bottom-up kinetic models of metabolism. Bmc Systems Biology. 10: 40. PMID 27266508 DOI: 10.1186/s12918-016-0283-2  1
2016 Feist AM, Palsson BO. What do cells actually want? Genome Biology. 17: 110. PMID 27215675 DOI: 10.1186/s13059-016-0983-3  1
2016 Brunk E, George KW, Alonso-Gutierrez J, Thompson M, Baidoo E, Wang G, Petzold CJ, McCloskey D, Monk J, Yang L, O'Brien EJ, Batth TS, Martin HG, Feist A, Adams PD, ... ... Palsson BO, et al. Characterizing Strain Variation in Engineered E. coli Using a Multi-Omics-Based Workflow. Cell Systems. PMID 27211860 DOI: 10.1016/j.cels.2016.04.004  1
2016 Levering J, Broddrick J, Dupont CL, Peers G, Beeri K, Mayers J, Gallina AA, Allen AE, Palsson BO, Zengler K. Genome-Scale Model Reveals Metabolic Basis of Biomass Partitioning in a Model Diatom. Plos One. 11: e0155038. PMID 27152931 DOI: 10.1371/journal.pone.0155038  1
2016 Utrilla J, O'Brien EJ, Chen K, McCloskey D, Cheung J, Wang H, Armenta-Medina D, Feist AM, Palsson BO. Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution. Cell Systems. 2: 260-271. PMID 27135538 DOI: 10.1016/j.cels.2016.04.003  1
2016 McCloskey D, Young JD, Xu S, Palsson BØ, Feist AM. A modeling method for increased precision and scope of directly measurable fluxes at a genome-scale. Analytical Chemistry. PMID 26981784 DOI: 10.1021/acs.analchem.5b04914  1
2016 Brunk E, Mih N, Monk J, Zhang Z, O'Brien EJ, Bliven SE, Chen K, Chang RL, Bourne PE, Palsson BO. Systems biology of the structural proteome. Bmc Systems Biology. 10: 26. PMID 26969117 DOI: 10.1186/s12918-016-0271-6  1
2016 Sandberg TE, Long CP, Gonzalez JE, Feist AM, Antoniewicz MR, Palsson BO. Evolution of E. coli on [U-13C]Glucose Reveals a Negligible Isotopic Influence on Metabolism and Physiology. Plos One. 11: e0151130. PMID 26964043 DOI: 10.1371/journal.pone.0151130  1
2016 Golabgir A, Gutierrez JM, Hefzi H, Li S, Palsson BO, Herwig C, Lewis NE. Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow. Biotechnology Advances. PMID 26948029 DOI: 10.1016/j.biotechadv.2016.02.011  1
2016 Bordbar A, Johansson PI, Paglia G, Harrison SJ, Wichuk K, Magnusdottir M, Valgeirsdottir S, Gybel-Brask M, Ostrowski SR, Palsson S, Rolfsson O, Sigurjónsson OE, Hansen MB, Gudmundsson S, Palsson BO. Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomes. Transfusion. PMID 26749434 DOI: 10.1111/trf.13460  1
2015 Bordbar A, McCloskey D, Zielinski DC, Sonnenschein N, Jamshidi N, Palsson BO. Personalized Whole-Cell Kinetic Models of Metabolism for Discovery in Genomics and Pharmacodynamics. Cell Systems. 1: 283-292. PMID 27136057 DOI: 10.1016/j.cels.2015.10.003  1
2015 McCloskey D, Young JD, Xu S, Palsson BØ, Feist AM. MID Max: A LC-MS/MS method for measuring the precursor and product mass isotopomer distributions (MIDs) of metabolic intermediates and cofactors for metabolic flux analysis (MFA) applications. Analytical Chemistry. PMID 26666286 DOI: 10.1021/acs.analchem.5b03887  1
2015 Aziz RK, Monk JM, Lewis RM, In Loh S, Mishra A, Abhay Nagle A, Satyanarayana C, Dhakshinamoorthy S, Luche M, Kitchen DB, Andrews KA, Fong NL, Li HJ, Palsson BO, Charusanti P. Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations. Scientific Reports. 5: 16025. PMID 26531810 DOI: 10.1038/srep16025  1
2015 King ZA, Lu J, Dräger A, Miller P, Federowicz S, Lerman JA, Ebrahim A, Palsson BO, Lewis NE. BiGG Models: A platform for integrating, standardizing and sharing genome-scale models. Nucleic Acids Research. PMID 26476456 DOI: 10.1093/nar/gkv1049  1
2015 Ebrahim A, Almaas E, Bauer E, Bordbar A, Burgard AP, Chang RL, Dräger A, Famili I, Feist AM, Fleming RM, Fong SS, Hatzimanikatis V, Herrgård MJ, Holder A, Hucka M, ... ... Palsson BO, et al. Do genome-scale models need exact solvers or clearer standards? Molecular Systems Biology. 11: 831. PMID 26467284  1
2015 Dräger A, Zielinski DC, Keller R, Rall M, Eichner J, Palsson BO, Zell A. SBMLsqueezer 2: context-sensitive creation of kinetic equations in biochemical networks. Bmc Systems Biology. 9: 68. PMID 26452770 DOI: 10.1186/s12918-015-0212-9  1
2015 Aziz RK, Khaw VL, Monk JM, Brunk E, Lewis R, Loh SI, Mishra A, Nagle AA, Satyanarayana C, Dhakshinamoorthy S, Luche M, Kitchen DB, Andrews KA, Palsson BØ, Charusanti P. Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC. Frontiers in Microbiology. 6: 958. PMID 26441892 DOI: 10.3389/fmicb.2015.00958  1
2015 King ZA, Dräger A, Ebrahim A, Sonnenschein N, Lewis NE, Palsson BO. Escher: A Web Application for Building, Sharing, and Embedding Data-Rich Visualizations of Biological Pathways. Plos Computational Biology. 11: e1004321. PMID 26313928 DOI: 10.1371/journal.pcbi.1004321  1
2015 Seo SW, Kim D, Szubin R, Palsson BO. Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655. Cell Reports. PMID 26279566 DOI: 10.1016/j.celrep.2015.07.043  1
2015 Yang L, Tan J, O'Brien EJ, Monk JM, Kim D, Li HJ, Charusanti P, Ebrahim A, Lloyd CJ, Yurkovich JT, Du B, Dräger A, Thomas A, Sun Y, Saunders MA, ... Palsson BO, et al. Systems biology definition of the core proteome of metabolism and expression is consistent with high-throughput data. Proceedings of the National Academy of Sciences of the United States of America. PMID 26261351 DOI: 10.1073/pnas.1501384112  1
2015 Seo SW, Kim D, O'Brien EJ, Szubin R, Palsson BO. Decoding genome-wide GadEWX-transcriptional regulatory networks reveals multifaceted cellular responses to acid stress in Escherichia coli. Nature Communications. 6: 7970. PMID 26258987 DOI: 10.1038/ncomms8970  1
2015 Rodriguez N, Thomas A, Watanabe L, Vazirabad IY, Kofia V, Gómez HF, Mittag F, Matthes J, Rudolph J, Wrzodek F, Netz E, Diamantikos A, Eichner J, Keller R, Wrzodek C, ... ... Palsson BØ, et al. JSBML 1.0: providing a smorgasbord of options to encode systems biology models. Bioinformatics (Oxford, England). PMID 26079347 DOI: 10.1093/bioinformatics/btv341  1
2015 Zielinski DC, Filipp FV, Bordbar A, Jensen K, Smith JW, Herrgard MJ, Mo ML, Palsson BO. Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis. Nature Communications. 6: 7101. PMID 26055627 DOI: 10.1038/ncomms8101  1
2015 O'Brien EJ, Monk JM, Palsson BO. Using Genome-scale Models to Predict Biological Capabilities. Cell. 161: 971-987. PMID 26000478 DOI: 10.1016/j.cell.2015.05.019  1
2015 Aurich MK, Paglia G, Rolfsson Ó, Hrafnsdóttir S, Magnúsdóttir M, Stefaniak MM, Palsson BØ, Fleming RM, Thiele I. Prediction of intracellular metabolic states from extracellular metabolomic data. Metabolomics : Official Journal of the Metabolomic Society. 11: 603-619. PMID 25972769 DOI: 10.1007/s11306-014-0721-3  1
2015 Rolfsson Ó, Palsson BO. Decoding the jargon of bottom-up metabolic systems biology. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 588-91. PMID 25761171 DOI: 10.1002/bies.201400187  0.84
2015 Pacini T, Fu W, Gudmundsson S, Chiaravalle AE, Brynjolfson S, Palsson BO, Astarita G, Paglia G. Multidimensional analytical approach based on UHPLC-UV-ion mobility-MS for the screening of natural pigments. Analytical Chemistry. 87: 2593-9. PMID 25647265 DOI: 10.1021/ac504707n  0.84
2015 O'Brien EJ, Palsson BO. Computing the functional proteome: recent progress and future prospects for genome-scale models. Current Opinion in Biotechnology. 34: 125-134. PMID 25576845 DOI: 10.1016/j.copbio.2014.12.017  1
2015 King ZA, Lloyd CJ, Feist AM, Palsson BO. Next-generation genome-scale models for metabolic engineering. Current Opinion in Biotechnology. 35: 23-29. PMID 25575024 DOI: 10.1016/j.copbio.2014.12.016  1
2015 Guzmán GI, Utrilla J, Nurk S, Brunk E, Monk JM, Ebrahim A, Palsson BO, Feist AM. Model-driven discovery of underground metabolic functions in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 112: 929-34. PMID 25564669 DOI: 10.1073/pnas.1414218112  1
2015 Paglia G, Angel P, Williams JP, Richardson K, Olivos HJ, Thompson JW, Menikarachchi L, Lai S, Walsh C, Moseley A, Plumb RS, Grant DF, Palsson BO, Langridge J, Geromanos S, et al. Ion mobility-derived collision cross section as an additional measure for lipid fingerprinting and identification. Analytical Chemistry. 87: 1137-44. PMID 25495617 DOI: 10.1021/ac503715v  0.84
2015 LaCroix RA, Sandberg TE, O'Brien EJ, Utrilla J, Ebrahim A, Guzman GI, Szubin R, Palsson BO, Feist AM. Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium. Applied and Environmental Microbiology. 81: 17-30. PMID 25304508 DOI: 10.1128/AEM.02246-14  1
2015 Paglia G, Sigurjónsson ÓE, Rolfsson Ó, Hansen MB, Brynjólfsson S, Gudmundsson S, Palsson BO. Metabolomic analysis of platelets during storage: a comparison between apheresis- and buffy coat-derived platelet concentrates. Transfusion. 55: 301-13. PMID 25156572 DOI: 10.1111/trf.12834  0.84
2015 Palsson BO. Systems biology: Constraint-based reconstruction and analysis Systems Biology: Constraint-Based Reconstruction and Analysis. 1-531. DOI: 10.1017/CBO9781139854610  1
2015 Bordbar A, McCloskey D, Zielinski DC, Sonnenschein N, Jamshidi N, Palsson BO. Personalized Whole-Cell Kinetic Models of Metabolism for Discovery in Genomics and Pharmacodynamics Cell Systems. 1: 283-292. DOI: 10.1016/j.cels.2015.10.003  1
2015 McCloskey D, Gangoiti JA, Palsson BO, Feist AM. A pH and solvent optimized reverse-phase ion-paring-LC–MS/MS method that leverages multiple scan-types for targeted absolute quantification of intracellular metabolites Metabolomics. 11: 1338-1350. DOI: 10.1007/s11306-015-0790-y  1
2014 Latif H, Szubin R, Tan J, Brunk E, Lechner A, Zengler K, Palsson BO. A streamlined ribosome profiling protocol for the characterization of microorganisms. Biotechniques. 58: 329-32. PMID 26054770 DOI: 10.2144/000114302  1
2014 Dräger A, Palsson BØ. Improving collaboration by standardization efforts in systems biology. Frontiers in Bioengineering and Biotechnology. 2: 61. PMID 25538939 DOI: 10.3389/fbioe.2014.00061  1
2014 Nam H, Campodonico M, Bordbar A, Hyduke DR, Kim S, Zielinski DC, Palsson BO. A systems approach to predict oncometabolites via context-specific genome-scale metabolic networks. Plos Computational Biology. 10: e1003837. PMID 25232952 DOI: 10.1371/journal.pcbi.1003837  1
2014 Liu JK, O'Brien EJ, Lerman JA, Zengler K, Palsson BO, Feist AM. Reconstruction and modeling protein translocation and compartmentalization in Escherichia coli at the genome-scale. Bmc Systems Biology. 8: 110. PMID 25227965 DOI: 10.1186/s12918-014-0110-6  1
2014 Seo SW, Kim D, Latif H, O'Brien EJ, Szubin R, Palsson BO. Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli. Nature Communications. 5: 4910. PMID 25222563 DOI: 10.1038/ncomms5910  1
2014 Latif H, Li HJ, Charusanti P, Palsson BØ, Aziz RK. A Gapless, Unambiguous Genome Sequence of the Enterohemorrhagic Escherichia coli O157:H7 Strain EDL933. Genome Announcements. 2. PMID 25125650 DOI: 10.1128/genomeA.00821-14  0.96
2014 Campodonico MA, Andrews BA, Asenjo JA, Palsson BO, Feist AM. Generation of an atlas for commodity chemical production in Escherichia coli and a novel pathway prediction algorithm, GEM-Path. Metabolic Engineering. 25: 140-58. PMID 25080239 DOI: 10.1016/j.ymben.2014.07.009  1
2014 Sandberg TE, Pedersen M, LaCroix RA, Ebrahim A, Bonde M, Herrgard MJ, Palsson BO, Sommer M, Feist AM. Evolution of Escherichia coli to 42 °C and subsequent genetic engineering reveals adaptive mechanisms and novel mutations. Molecular Biology and Evolution. 31: 2647-62. PMID 25015645 DOI: 10.1093/molbev/msu209  1
2014 Bordbar A, Nagarajan H, Lewis NE, Latif H, Ebrahim A, Federowicz S, Schellenberger J, Palsson BO. Minimal metabolic pathway structure is consistent with associated biomolecular interactions. Molecular Systems Biology. 10: 737. PMID 24987116 DOI: 10.15252/msb.20145243  1
2014 Monk J, Palsson BO. Genetics. Predicting microbial growth. Science (New York, N.Y.). 344: 1448-9. PMID 24970063 DOI: 10.1126/science.1253388  1
2014 Rohatgi N, Nielsen TK, Bjørn SP, Axelsson I, Paglia G, Voldborg BG, Palsson BO, Rolfsson Ó. Biochemical characterization of human gluconokinase and the proposed metabolic impact of gluconic acid as determined by constraint based metabolic network analysis. Plos One. 9: e98760. PMID 24896608 DOI: 10.1371/journal.pone.0098760  1
2014 Paglia G, Sigurjónsson ÓE, Rolfsson Ó, Valgeirsdottir S, Hansen MB, Brynjólfsson S, Gudmundsson S, Palsson BO. Comprehensive metabolomic study of platelets reveals the expression of discrete metabolic phenotypes during storage. Transfusion. 54: 2911-23. PMID 24840017 DOI: 10.1111/trf.12710  1
2014 Monk J, Nogales J, Palsson BO. Optimizing genome-scale network reconstructions. Nature Biotechnology. 32: 447-52. PMID 24811519 DOI: 10.1038/nbt.2870  1
2014 Paglia G, Williams JP, Menikarachchi L, Thompson JW, Tyldesley-Worster R, Halldórsson S, Rolfsson O, Moseley A, Grant D, Langridge J, Palsson BO, Astarita G. Ion mobility derived collision cross sections to support metabolomics applications. Analytical Chemistry. 86: 3985-93. PMID 24640936 DOI: 10.1021/ac500405x  0.84
2014 Cheng KK, Lee BS, Masuda T, Ito T, Ikeda K, Hirayama A, Deng L, Dong J, Shimizu K, Soga T, Tomita M, Palsson BO, Robert M. Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol. Nature Communications. 5: 3233. PMID 24481126 DOI: 10.1038/ncomms4233  1
2014 Thomas A, Rahmanian S, Bordbar A, Palsson BØ, Jamshidi N. Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. Scientific Reports. 4: 3925. PMID 24473230 DOI: 10.1038/srep03925  1
2014 Cho BK, Kim D, Knight EM, Zengler K, Palsson BO. Genome-scale reconstruction of the sigma factor network in Escherichia coli: topology and functional states. Bmc Biology. 12: 4. PMID 24461193 DOI: 10.1186/1741-7007-12-4  1
2014 Bordbar A, Monk JM, King ZA, Palsson BO. Constraint-based models predict metabolic and associated cellular functions. Nature Reviews. Genetics. 15: 107-20. PMID 24430943 DOI: 10.1038/nrg3643  1
2014 Huang TW, Lam I, Chang HY, Tsai SF, Palsson BO, Charusanti P. Capsule deletion via a λ-Red knockout system perturbs biofilm formation and fimbriae expression in Klebsiella pneumoniae MGH 78578. Bmc Research Notes. 7: 13. PMID 24398052 DOI: 10.1186/1756-0500-7-13  1
2014 Fu W, Paglia G, Magnúsdóttir M, Steinarsdóttir EA, Gudmundsson S, Palsson BØ, Andrésson ÓS, Brynjólfsson S. Effects of abiotic stressors on lutein production in the green microalga Dunaliella salina. Microbial Cell Factories. 13: 3. PMID 24397433 DOI: 10.1186/1475-2859-13-3  0.84
2014 McCloskey D, Gangoiti JA, King ZA, Naviaux RK, Barshop BA, Palsson BO, Feist AM. A model-driven quantitative metabolomics analysis of aerobic and anaerobic metabolism in E. coli K-12 MG1655 that is biochemically and thermodynamically consistent. Biotechnology and Bioengineering. 111: 803-15. PMID 24249002 DOI: 10.1002/bit.25133  1
2014 Hwang KS, Kim HU, Charusanti P, Palsson BØ, Lee SY. Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites. Biotechnology Advances. 32: 255-68. PMID 24189093 DOI: 10.1016/j.biotechadv.2013.10.008  1
2014 McCloskey D, Utrilla J, Naviaux RK, Palsson BO, Feist AM. Fast Swinnex filtration (FSF): a fast and robust sampling and extraction method suitable for metabolomics analysis of cultures grown in complex media Metabolomics. 11: 198-209. DOI: 10.1007/s11306-014-0686-2  1
2014 Bordbar A, Palsson BO. Moving toward genome-scale kinetic models: The mass action stoichiometric simulation approach Functional Coherence of Molecular Networks in Bioinformatics. 201-220. DOI: 10.1007/978-1-4614-0320-3_8  1
2013 Monk JM, Charusanti P, Aziz RK, Lerman JA, Premyodhin N, Orth JD, Feist AM, Palsson BØ. Genome-scale metabolic reconstructions of multiple Escherichia coli strains highlight strain-specific adaptations to nutritional environments. Proceedings of the National Academy of Sciences of the United States of America. 110: 20338-43. PMID 24277855 DOI: 10.1073/pnas.1307797110  1
2013 Nagarajan H, Embree M, Rotaru AE, Shrestha PM, Feist AM, Palsson BØ, Lovley DR, Zengler K. Characterization and modelling of interspecies electron transfer mechanisms and microbial community dynamics of a syntrophic association. Nature Communications. 4: 2809. PMID 24264237 DOI: 10.1038/ncomms3809  1
2013 Chang RL, Xie L, Bourne PE, Palsson BO. Antibacterial mechanisms identified through structural systems pharmacology. Bmc Systems Biology. 7: 102. PMID 24112686 DOI: 10.1186/1752-0509-7-102  1
2013 O'Brien EJ, Lerman JA, Chang RL, Hyduke DR, Palsson BØ. Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction. Molecular Systems Biology. 9: 693. PMID 24084808 DOI: 10.1038/msb.2013.52  1
2013 Palsson S, Hickling TP, Bradshaw-Pierce EL, Zager M, Jooss K, O'Brien PJ, Spilker ME, Palsson BO, Vicini P. The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models. Bmc Systems Biology. 7: 95. PMID 24074340 DOI: 10.1186/1752-0509-7-95  1
2013 Schmidt BJ, Ebrahim A, Metz TO, Adkins JN, Palsson BØ, Hyduke DR. GIM3E: condition-specific models of cellular metabolism developed from metabolomics and expression data. Bioinformatics (Oxford, England). 29: 2900-8. PMID 23975765 DOI: 10.1093/bioinformatics/btt493  1
2013 Ebrahim A, Lerman JA, Palsson BO, Hyduke DR. COBRApy: COnstraints-Based Reconstruction and Analysis for Python. Bmc Systems Biology. 7: 74. PMID 23927696 DOI: 10.1186/1752-0509-7-74  1
2013 Wu W, Jamshidi N, Eraly SA, Liu HC, Bush KT, Palsson BO, Nigam SK. Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1825-34. PMID 23920220 DOI: 10.1124/dmd.113.052647  1
2013 Lewis NE, Liu X, Li Y, Nagarajan H, Yerganian G, O'Brien E, Bordbar A, Roth AM, Rosenbloom J, Bian C, Xie M, Chen W, Li N, Baycin-Hizal D, Latif H, ... ... Palsson BO, et al. Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome. Nature Biotechnology. 31: 759-65. PMID 23873082 DOI: 10.1038/nbt.2624  1
2013 Nguyen DD, Wu CH, Moree WJ, Lamsa A, Medema MH, Zhao X, Gavilan RG, Aparicio M, Atencio L, Jackson C, Ballesteros J, Sanchez J, Watrous JD, Phelan VV, van de Wiel C, ... ... Palsson BØ, et al. MS/MS networking guided analysis of molecule and gene cluster families. Proceedings of the National Academy of Sciences of the United States of America. 110: E2611-20. PMID 23798442 DOI: 10.1073/pnas.1303471110  1
2013 Chang RL, Andrews K, Kim D, Li Z, Godzik A, Palsson BO. Structural systems biology evaluation of metabolic thermotolerance in Escherichia coli. Science (New York, N.Y.). 340: 1220-3. PMID 23744946 DOI: 10.1126/science.1234012  1
2013 McCloskey D, Palsson BØ, Feist AM. Basic and applied uses of genome-scale metabolic network reconstructions of Escherichia coli. Molecular Systems Biology. 9: 661. PMID 23632383 DOI: 10.1038/msb.2013.18  1
2013 Qiu Y, Nagarajan H, Embree M, Shieu W, Abate E, Juárez K, Cho BK, Elkins JG, Nevin KP, Barrett CL, Lovley DR, Palsson BO, Zengler K. Characterizing the interplay between multiple levels of organization within bacterial sigma factor regulatory networks. Nature Communications. 4: 1755. PMID 23612296 DOI: 10.1038/ncomms2743  1
2013 Kim YM, Schmidt BJ, Kidwai AS, Jones MB, Deatherage Kaiser BL, Brewer HM, Mitchell HD, Palsson BO, McDermott JE, Heffron F, Smith RD, Peterson SN, Ansong C, Hyduke DR, Metz TO, et al. Salmonella modulates metabolism during growth under conditions that induce expression of virulence genes. Molecular Biosystems. 9: 1522-34. PMID 23559334 DOI: 10.1039/c3mb25598k  1
2013 Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, Thorleifsson SG, Agren R, Bölling C, Bordel S, Chavali AK, ... ... Palsson BØ, et al. A community-driven global reconstruction of human metabolism. Nature Biotechnology. 31: 419-25. PMID 23455439 DOI: 10.1038/nbt.2488  1
2013 Fong NL, Lerman JA, Lam I, Palsson BO, Charusanti P. Reconciling a Salmonella enterica metabolic model with experimental data confirms that overexpression of the glyoxylate shunt can rescue a lethal ppc deletion mutant. Fems Microbiology Letters. 342: 62-9. PMID 23432746 DOI: 10.1111/1574-6968.12109  1
2013 Hyduke DR, Lewis NE, Palsson BØ. Analysis of omics data with genome-scale models of metabolism. Molecular Biosystems. 9: 167-74. PMID 23247105 DOI: 10.1039/c2mb25453k  1
2013 Fu W, Guðmundsson O, Paglia G, Herjólfsson G, Andrésson OS, Palsson BO, Brynjólfsson S. Enhancement of carotenoid biosynthesis in the green microalga Dunaliella salina with light-emitting diodes and adaptive laboratory evolution. Applied Microbiology and Biotechnology. 97: 2395-403. PMID 23095941 DOI: 10.1007/s00253-012-4502-5  1
2013 Rolfsson Ó, Paglia G, Magnusdóttir M, Palsson BØ, Thiele I. Inferring the metabolism of human orphan metabolites from their metabolic network context affirms human gluconokinase activity. The Biochemical Journal. 449: 427-35. PMID 23067238 DOI: 10.1042/BJ20120980  1
2013 Ansong C, Deatherage BL, Hyduke D, Schmidt B, McDermott JE, Jones MB, Chauhan S, Charusanti P, Kim YM, Nakayasu ES, Li J, Kidwai A, Niemann G, Brown RN, Metz TO, ... ... Palsson BO, et al. Studying Salmonellae and Yersiniae host-pathogen interactions using integrated 'omics and modeling. Current Topics in Microbiology and Immunology. 363: 21-41. PMID 22886542 DOI: 10.1007/82_2012_247  1
2013 Hefzi H, Palsson BO, Lewis NE. Reconstruction of Genome-Scale Metabolic Networks Handbook of Systems Biology. 229-250. DOI: 10.1016/B978-0-12-385944-0.00012-5  1
2013 Zielinski DC, Palsson BO. Kinetic modeling of metabolic networks Systems Metabolic Engineering. 25-55. DOI: 10.1007/978-94-007-4534-6_2  1
2013 Lee SY, Sohn SB, Kim HU, Park JM, Kim TY, Orth JD, Palsson BO. Genome-scale network modeling Systems Metabolic Engineering. 1-23. DOI: 10.1007/978-94-007-4534-6_1  1
2012 Seo JH, Hong JS, Kim D, Cho BK, Huang TW, Tsai SF, Palsson BO, Charusanti P. Multiple-omic data analysis of Klebsiella pneumoniae MGH 78578 reveals its transcriptional architecture and regulatory features. Bmc Genomics. 13: 679. PMID 23194155 DOI: 10.1186/1471-2164-13-679  1
2012 Fu W, Magnúsdóttir M, Brynjólfson S, Palsson BØ, Paglia G. UPLC-UV-MS(E) analysis for quantification and identification of major carotenoid and chlorophyll species in algae. Analytical and Bioanalytical Chemistry. 404: 3145-54. PMID 23052878 DOI: 10.1007/s00216-012-6434-4  1
2012 Thiele I, Fleming RM, Que R, Bordbar A, Diep D, Palsson BO. Multiscale modeling of metabolism and macromolecular synthesis in E. coli and its application to the evolution of codon usage. Plos One. 7: e45635. PMID 23029152 DOI: 10.1371/journal.pone.0045635  1
2012 Paglia G, Palsson BØ, Sigurjonsson OE. Systems biology of stored blood cells: can it help to extend the expiration date? Journal of Proteomics. 76: 163-7. PMID 22982136 DOI: 10.1016/j.jprot.2012.08.014  1
2012 Baycin-Hizal D, Tabb DL, Chaerkady R, Chen L, Lewis NE, Nagarajan H, Sarkaria V, Kumar A, Wolozny D, Colao J, Jacobson E, Tian Y, O'Meally RN, Krag SS, Cole RN, ... Palsson BO, et al. Proteomic analysis of Chinese hamster ovary cells. Journal of Proteome Research. 11: 5265-76. PMID 22971049 DOI: 10.1021/pr300476w  1
2012 Nam H, Lewis NE, Lerman JA, Lee DH, Chang RL, Kim D, Palsson BO. Network context and selection in the evolution to enzyme specificity. Science (New York, N.Y.). 337: 1101-4. PMID 22936779 DOI: 10.1126/science.1216861  1
2012 Kim D, Hong JS, Qiu Y, Nagarajan H, Seo JH, Cho BK, Tsai SF, Palsson BØ. Comparative analysis of regulatory elements between Escherichia coli and Klebsiella pneumoniae by genome-wide transcription start site profiling. Plos Genetics. 8: e1002867. PMID 22912590 DOI: 10.1371/journal.pgen.1002867  1
2012 Fu W, Gudmundsson O, Feist AM, Herjolfsson G, Brynjolfsson S, Palsson BØ. Maximizing biomass productivity and cell density of Chlorella vulgaris by using light-emitting diode-based photobioreactor. Journal of Biotechnology. 161: 242-9. PMID 22796827 DOI: 10.1016/j.jbiotec.2012.07.004  1
2012 Lerman JA, Hyduke DR, Latif H, Portnoy VA, Lewis NE, Orth JD, Schrimpe-Rutledge AC, Smith RD, Adkins JN, Zengler K, Palsson BO. In silico method for modelling metabolism and gene product expression at genome scale. Nature Communications. 3: 929. PMID 22760628 DOI: 10.1038/ncomms1928  1
2012 Bordbar A, Mo ML, Nakayasu ES, Schrimpe-Rutledge AC, Kim YM, Metz TO, Jones MB, Frank BC, Smith RD, Peterson SN, Hyduke DR, Adkins JN, Palsson BO. Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation. Molecular Systems Biology. 8: 558. PMID 22735334 DOI: 10.1038/msb.2012.21  1
2012 Paglia G, Magnúsdóttir M, Thorlacius S, Sigurjónsson OE, Guðmundsson S, Palsson BØ, Thiele I. Intracellular metabolite profiling of platelets: evaluation of extraction processes and chromatographic strategies. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 898: 111-20. PMID 22608809 DOI: 10.1016/j.jchromb.2012.04.026  1
2012 Charusanti P, Fong NL, Nagarajan H, Pereira AR, Li HJ, Abate EA, Su Y, Gerwick WH, Palsson BO. Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction. Plos One. 7: e33727. PMID 22470465 DOI: 10.1371/journal.pone.0033727  1
2012 Zengler K, Palsson BO. A road map for the development of community systems (CoSy) biology. Nature Reviews. Microbiology. 10: 366-72. PMID 22450377 DOI: 10.1038/nrmicro2763  1
2012 Lewis NE, Nagarajan H, Palsson BO. Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. Nature Reviews. Microbiology. 10: 291-305. PMID 22367118 DOI: 10.1038/nrmicro2737  1
2012 Nogales J, Gudmundsson S, Knight EM, Palsson BO, Thiele I. Detailing the optimality of photosynthesis in cyanobacteria through systems biology analysis. Proceedings of the National Academy of Sciences of the United States of America. 109: 2678-83. PMID 22308420 DOI: 10.1073/pnas.1117907109  1
2012 Paglia G, Hrafnsdóttir S, Magnúsdóttir M, Fleming RM, Thorlacius S, Palsson BØ, Thiele I. Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole-time of flight mass spectrometry (UPLC-Q-ToF-MS). Analytical and Bioanalytical Chemistry. 402: 1183-98. PMID 22159369 DOI: 10.1007/s00216-011-5556-4  1
2012 Bordbar A, Palsson BO. Using the reconstructed genome-scale human metabolic network to study physiology and pathology. Journal of Internal Medicine. 271: 131-41. PMID 22142339 DOI: 10.1111/j.1365-2796.2011.02494.x  1
2012 Cho BK, Federowicz S, Park YS, Zengler K, Palsson BØ. Deciphering the transcriptional regulatory logic of amino acid metabolism. Nature Chemical Biology. 8: 65-71. PMID 22082910 DOI: 10.1038/nchembio.710  1
2012 Fleming RM, Maes CM, Saunders MA, Ye Y, Palsson BØ. A variational principle for computing nonequilibrium fluxes and potentials in genome-scale biochemical networks. Journal of Theoretical Biology. 292: 71-7. PMID 21983269 DOI: 10.1016/j.jtbi.2011.09.029  1
2011 Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bmc Systems Biology. 5: 180. PMID 22041191 DOI: 10.1186/1752-0509-5-180  1
2011 Lee DH, Feist AM, Barrett CL, Palsson BØ. Cumulative number of cell divisions as a meaningful timescale for adaptive laboratory evolution of Escherichia coli. Plos One. 6: e26172. PMID 22028828 DOI: 10.1371/journal.pone.0026172  1
2011 Charusanti P, Chauhan S, McAteer K, Lerman JA, Hyduke DR, Motin VL, Ansong C, Adkins JN, Palsson BO. An experimentally-supported genome-scale metabolic network reconstruction for Yersinia pestis CO92. Bmc Systems Biology. 5: 163. PMID 21995956 DOI: 10.1186/1752-0509-5-163  1
2011 Orth JD, Conrad TM, Na J, Lerman JA, Nam H, Feist AM, Palsson BØ. A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011. Molecular Systems Biology. 7: 535. PMID 21988831 DOI: 10.1038/msb.2011.65  1
2011 Rolfsson O, Palsson BØ, Thiele I. The human metabolic reconstruction Recon 1 directs hypotheses of novel human metabolic functions. Bmc Systems Biology. 5: 155. PMID 21962087 DOI: 10.1186/1752-0509-5-155  0.72
2011 Schellenberger J, Que R, Fleming RM, Thiele I, Orth JD, Feist AM, Zielinski DC, Bordbar A, Lewis NE, Rahmanian S, Kang J, Hyduke DR, Palsson BØ. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0. Nature Protocols. 6: 1290-307. PMID 21886097 DOI: 10.1038/nprot.2011.308  1
2011 Chang RL, Ghamsari L, Manichaikul A, Hom EF, Balaji S, Fu W, Shen Y, Hao T, Palsson BØ, Salehi-Ashtiani K, Papin JA. Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism. Molecular Systems Biology. 7: 518. PMID 21811229 DOI: 10.1038/msb.2011.52  1
2011 Xu X, Nagarajan H, Lewis NE, Pan S, Cai Z, Liu X, Chen W, Xie M, Wang W, Hammond S, Andersen MR, Neff N, Passarelli B, Koh W, Fan HC, ... ... Palsson BO, et al. The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line. Nature Biotechnology. 29: 735-41. PMID 21804562 DOI: 10.1038/nbt.1932  1
2011 Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, Bush KT, Gallegos TF, Sweet DH, Palsson BØ, Nigam SK. Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. The Journal of Biological Chemistry. 286: 31522-31. PMID 21757732 DOI: 10.1074/jbc.M111.272534  1
2011 Bordbar A, Jamshidi N, Palsson BO. iAB-RBC-283: A proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological states. Bmc Systems Biology. 5: 110. PMID 21749716 DOI: 10.1186/1752-0509-5-110  1
2011 Conrad TM, Lewis NE, Palsson BØ. Microbial laboratory evolution in the era of genome-scale science. Molecular Systems Biology. 7: 509. PMID 21734648 DOI: 10.1038/msb.2011.42  1
2011 McDermott JE, Yoon H, Nakayasu ES, Metz TO, Hyduke DR, Kidwai AS, Palsson BO, Adkins JN, Heffron F. Technologies and approaches to elucidate and model the virulence program of salmonella. Frontiers in Microbiology. 2: 121. PMID 21687430 DOI: 10.3389/fmicb.2011.00121  1
2011 Cho BK, Federowicz SA, Embree M, Park YS, Kim D, Palsson BØ. The PurR regulon in Escherichia coli K-12 MG1655. Nucleic Acids Research. 39: 6456-64. PMID 21572102 DOI: 10.1093/nar/gkr307  1
2011 Applebee MK, Joyce AR, Conrad TM, Pettigrew DW, Palsson BØ. Functional and metabolic effects of adaptive glycerol kinase (GLPK) mutants in Escherichia coli. The Journal of Biological Chemistry. 286: 23150-9. PMID 21550976 DOI: 10.1074/jbc.M110.195305  1
2011 Liao YC, Huang TW, Chen FC, Charusanti P, Hong JS, Chang HY, Tsai SF, Palsson BO, Hsiung CA. An experimentally validated genome-scale metabolic reconstruction of Klebsiella pneumoniae MGH 78578, iYL1228. Journal of Bacteriology. 193: 1710-7. PMID 21296962 DOI: 10.1128/JB.01218-10  1
2011 Schellenberger J, Lewis NE, Palsson BØ. Elimination of thermodynamically infeasible loops in steady-state metabolic models. Biophysical Journal. 100: 544-53. PMID 21281568 DOI: 10.1016/j.bpj.2010.12.3707  1
2011 Thiele I, Hyduke DR, Steeb B, Fankam G, Allen DK, Bazzani S, Charusanti P, Chen FC, Fleming RM, Hsiung CA, De Keersmaecker SC, Liao YC, Marchal K, Mo ML, Özdemir E, ... ... Palsson BO, et al. A community effort towards a knowledge-base and mathematical model of the human pathogen Salmonella Typhimurium LT2. Bmc Systems Biology. 5: 8. PMID 21244678 DOI: 10.1186/1752-0509-5-8  1
2011 Mahadevan R, Palsson BØ, Lovley DR. In situ to in silico and back: elucidating the physiology and ecology of Geobacter spp. using genome-scale modelling. Nature Reviews. Microbiology. 9: 39-50. PMID 21132020 DOI: 10.1038/nrmicro2456  1
2011 Barrett CL, Cho BK, Palsson BO. Sensitive and accurate identification of protein-DNA binding events in ChIP-chip assays using higher order derivative analysis. Nucleic Acids Research. 39: 1656-65. PMID 21051353 DOI: 10.1093/nar/gkq848  1
2011 Tremblay PL, Summers ZM, Glaven RH, Nevin KP, Zengler K, Barrett CL, Qiu Y, Palsson BO, Lovley DR. A c-type cytochrome and a transcriptional regulator responsible for enhanced extracellular electron transfer in Geobacter sulfurreducens revealed by adaptive evolution. Environmental Microbiology. 13: 13-23. PMID 20636372 DOI: 10.1111/j.1462-2920.2010.02302.x  1
2011 Palsson B. Systems biology: Simulation of dynamic network states Systems Biology: Simulation of Dynamic Network States. 1-317. DOI: 10.1017/CBO9780511736179  1
2011 Jamshidi N, Palsson BO. Metabolic network dynamics: Properties and principles Understanding the Dynamics of Biological Systems: Lessons Learned From Integrative Systems Biology. 19-37. DOI: 10.1007/978-1-4419-7964-3_2  1
2010 Orth JD, Fleming RM, Palsson BØ. Reconstruction and Use of Microbial Metabolic Networks: the Core Escherichia coli Metabolic Model as an Educational Guide. Ecosal Plus. 4. PMID 26443778 DOI: 10.1128/ecosalplus.10.2.1  1
2010 Lewis NE, Schramm G, Bordbar A, Schellenberger J, Andersen MP, Cheng JK, Patel N, Yee A, Lewis RA, Eils R, König R, Palsson BØ. Large-scale in silico modeling of metabolic interactions between cell types in the human brain. Nature Biotechnology. 28: 1279-85. PMID 21102456 DOI: 10.1038/nbt.1711  1
2010 Lerman J, Palsson BO. Microbiology. Topping off a multiscale balancing act. Science (New York, N.Y.). 330: 1058-9. PMID 21097927 DOI: 10.1126/science.1199353  1
2010 Charusanti P, Conrad TM, Knight EM, Venkataraman K, Fong NL, Xie B, Gao Y, Palsson BØ. Genetic basis of growth adaptation of Escherichia coli after deletion of pgi, a major metabolic gene. Plos Genetics. 6: e1001186. PMID 21079674 DOI: 10.1371/journal.pgen.1001186  1
2010 Conrad TM, Frazier M, Joyce AR, Cho BK, Knight EM, Lewis NE, Landick R, Palsson BØ. RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media. Proceedings of the National Academy of Sciences of the United States of America. 107: 20500-5. PMID 21057108 DOI: 10.1073/pnas.0911253107  1
2010 Bordbar A, Lewis NE, Schellenberger J, Palsson BØ, Jamshidi N. Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions. Molecular Systems Biology. 6: 422. PMID 20959820 DOI: 10.1038/msb.2010.68  1
2010 Sigurdsson MI, Jamshidi N, Steingrimsson E, Thiele I, Palsson BØ. A detailed genome-wide reconstruction of mouse metabolism based on human Recon 1. Bmc Systems Biology. 4: 140. PMID 20959003 DOI: 10.1186/1752-0509-4-140  1
2010 Chang RL, Xie L, Xie L, Bourne PE, Palsson BØ. Drug off-target effects predicted using structural analysis in the context of a metabolic network model. Plos Computational Biology. 6: e1000938. PMID 20957118 DOI: 10.1371/journal.pcbi.1000938  1
2010 Portnoy VA, Scott DA, Lewis NE, Tarasova Y, Osterman AL, Palsson BØ. Deletion of genes encoding cytochrome oxidases and quinol monooxygenase blocks the aerobic-anaerobic shift in Escherichia coli K-12 MG1655. Applied and Environmental Microbiology. 76: 6529-40. PMID 20709841 DOI: 10.1128/AEM.01178-10  1
2010 Lewis NE, Hixson KK, Conrad TM, Lerman JA, Charusanti P, Polpitiya AD, Adkins JN, Schramm G, Purvine SO, Lopez-Ferrer D, Weitz KK, Eils R, König R, Smith RD, Palsson BØ. Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models. Molecular Systems Biology. 6: 390. PMID 20664636 DOI: 10.1038/msb.2010.47  1
2010 Qiu Y, Cho BK, Park YS, Lovley D, Palsson BØ, Zengler K. Structural and operational complexity of the Geobacter sulfurreducens genome. Genome Research. 20: 1304-11. PMID 20592237 DOI: 10.1101/gr.107540.110  1
2010 Orth JD, Palsson B. Systematizing the generation of missing metabolic knowledge Biotechnology and Bioengineering. 107: 403-412. PMID 20589842 DOI: 10.1002/bit.22844  1
2010 Nagarajan H, Butler JE, Klimes A, Qiu Y, Zengler K, Ward J, Young ND, Methé BA, Palsson BØ, Lovley DR, Barrett CL. De Novo assembly of the complete genome of an enhanced electricity-producing variant of Geobacter sulfurreducens using only short reads. Plos One. 5: e10922. PMID 20544019 DOI: 10.1371/journal.pone.0010922  1
2010 Thiele I, Fleming RM, Bordbar A, Schellenberger J, Palsson BØ. Functional characterization of alternate optimal solutions of Escherichia coli's transcriptional and translational machinery. Biophysical Journal. 98: 2072-81. PMID 20483314 DOI: 10.1016/j.bpj.2010.01.060  1
2010 Lee DH, Palsson BØ. Adaptive evolution of Escherichia coli K-12 MG1655 during growth on a Nonnative carbon source, L-1,2-propanediol. Applied and Environmental Microbiology. 76: 4158-68. PMID 20435762 DOI: 10.1128/AEM.00373-10  1
2010 Feist AM, Palsson BO. The biomass objective function. Current Opinion in Microbiology. 13: 344-9. PMID 20430689 DOI: 10.1016/j.mib.2010.03.003  1
2010 Schellenberger J, Park JO, Conrad TM, Palsson BØ. BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions. Bmc Bioinformatics. 11: 213. PMID 20426874 DOI: 10.1186/1471-2105-11-213  1
2010 Thiele I, Palsson BØ. Reconstruction annotation jamborees: a community approach to systems biology. Molecular Systems Biology. 6: 361. PMID 20393581 DOI: 10.1038/msb.2010.15  1
2010 Jamshidi N, Palsson BØ. Mass action stoichiometric simulation models: incorporating kinetics and regulation into stoichiometric models. Biophysical Journal. 98: 175-85. PMID 20338839 DOI: 10.1016/j.bpj.2009.09.064  1
2010 Orth JD, Thiele I, Palsson BO. What is flux balance analysis? Nature Biotechnology. 28: 245-248. PMID 20212490 DOI: 10.1038/nbt.1614  1
2010 Hyduke DR, Palsson BØ. Towards genome-scale signalling network reconstructions. Nature Reviews. Genetics. 11: 297-307. PMID 20177425 DOI: 10.1038/nrg2750  1
2010 Thiele I, Palsson BØ. A protocol for generating a high-quality genome-scale metabolic reconstruction. Nature Protocols. 5: 93-121. PMID 20057383 DOI: 10.1038/nprot.2009.203  1
2010 Feist AM, Zielinski DC, Orth JD, Schellenberger J, Herrgard MJ, Palsson BO. Model-driven evaluation of the production potential for growth-coupled products of Escherichia coli Metabolic Engineering. 12: 173-186. PMID 19840862 DOI: 10.1016/j.ymben.2009.10.003  1
2009 Oberhardt MA, Palsson BØ, Papin JA. Applications of genome-scale metabolic reconstructions. Molecular Systems Biology. 5: 320. PMID 19888215 DOI: 10.1038/msb.2009.77  1
2009 Cho BK, Zengler K, Qiu Y, Park YS, Knight EM, Barrett CL, Gao Y, Palsson BØ. The transcription unit architecture of the Escherichia coli genome. Nature Biotechnology. 27: 1043-9. PMID 19881496 DOI: 10.1038/nbt.1582  1
2009 Conrad TM, Joyce AR, Applebee MK, Barrett CL, Xie B, Gao Y, Palsson BØ. Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short-term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations. Genome Biology. 10: R118. PMID 19849850 DOI: 10.1186/gb-2009-10-10-r118  1
2009 Jamshidi N, Palsson BØ. Flux-concentration duality in dynamic nonequilibrium biological networks. Biophysical Journal. 97: L11-3. PMID 19720010 DOI: 10.1016/j.bpj.2009.06.049  1
2009 Cho BK, Palsson BØ. Can the protein occupancy landscape show the topologically isolated chromosomal domains in the E. coli genome?: An exciting prospect. Molecular Cell. 35: 255-6. PMID 19683488 DOI: 10.1016/j.molcel.2009.07.019  1
2009 Cho BK, Palsson BØ. Probing the basis for genotype-phenotype relationships. Nature Methods. 6: 565-6. PMID 19644456 DOI: 10.1038/nmeth0809-565  1
2009 Gianchandani EP, Joyce AR, Palsson BØ, Papin JA. Functional states of the genome-scale Escherichia coli transcriptional regulatory system. Plos Computational Biology. 5: e1000403. PMID 19503608 DOI: 10.1371/journal.pcbi.1000403  1
2009 Jamshidi N, Palsson BO. Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes. Bmc Systems Biology. 3: 44. PMID 19405968 DOI: 10.1186/1752-0509-3-44  1
2009 Lewis NE, Cho BK, Knight EM, Palsson BO. Gene expression profiling and the use of genome-scale in silico models of Escherichia coli for analysis: providing context for content. Journal of Bacteriology. 191: 3437-44. PMID 19363119 DOI: 10.1128/JB.00034-09  1
2009 Mo ML, Palsson BO, HerrgÃ¥rd MJ. Connecting extracellular metabolomic measurements to intracellular flux states in yeast. Bmc Systems Biology. 3: 37. PMID 19321003 DOI: 10.1186/1752-0509-3-37  1
2009 Thiele I, Jamshidi N, Fleming RM, Palsson BØ. Genome-scale reconstruction of Escherichia coli's transcriptional and translational machinery: a knowledge base, its mathematical formulation, and its functional characterization. Plos Computational Biology. 5: e1000312. PMID 19282977 DOI: 10.1371/journal.pcbi.1000312  1
2009 Li F, Thiele I, Jamshidi N, Palsson BØ. Identification of potential pathway mediation targets in Toll-like receptor signaling. Plos Computational Biology. 5: e1000292. PMID 19229310 DOI: 10.1371/journal.pcbi.1000292  1
2009 Sigurdsson MI, Jamshidi N, Jonsson JJ, Palsson BO. Genome-scale network analysis of imprinted human metabolic genes. Epigenetics. 4: 43-6. PMID 19218833 DOI: 10.4161/epi.4.1.7603  1
2009 Feist AM, HerrgÃ¥rd MJ, Thiele I, Reed JL, Palsson BØ. Reconstruction of biochemical networks in microorganisms. Nature Reviews. Microbiology. 7: 129-43. PMID 19116616 DOI: 10.1038/nrmicro1949  1
2009 Mo ML, Palsson BØ. Understanding human metabolic physiology: a genome-to-systems approach. Trends in Biotechnology. 27: 37-44. PMID 19010556 DOI: 10.1016/j.tibtech.2008.09.007  1
2009 Schellenberger J, Palsson BØ. Use of randomized sampling for analysis of metabolic networks. The Journal of Biological Chemistry. 284: 5457-61. PMID 18940807 DOI: 10.1074/jbc.R800048200  1
2009 Feist AM, Thiele I, Palsson B. Genome-scale reconstruction, modeling, and simulation of E. coli's metabolic network Systems Biology and Biotechnology of Escherichia Coli. 149-176. DOI: 10.1007/978-1-4020-9394-4_9  1
2009 Applebee MK, Palsson B. Genome-scale models and the genetic basis for E. coli adaptation Systems Biology and Biotechnology of Escherichia Coli. 237-256. DOI: 10.1007/978-1-4020-9394-4_12  1
2009 Joyce AR, Palsson B. In Silico Genome-Scale Metabolic Models: The Constraint-Based Approach and Its Applications Systems Biology and Synthetic Biology. 193-233. DOI: 10.1002/9780470437988.ch6  1
2009 Palsson B. Foreword Systems Biology and Synthetic Biology. ix. DOI: 10.1002/9780470437988  1
2008 Cho BK, Barrett CL, Knight EM, Park YS, Palsson BØ. Genome-scale reconstruction of the Lrp regulatory network in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 105: 19462-7. PMID 19052235 DOI: 10.1073/pnas.0807227105  1
2008 Portnoy VA, Herrgård MJ, Palsson BØ. Aerobic fermentation of D-glucose by an evolved cytochrome oxidase-deficient Escherichia coli strain. Applied and Environmental Microbiology. 74: 7561-9. PMID 18952873 DOI: 10.1128/AEM.00880-08  1
2008 HerrgÃ¥rd MJ, Swainston N, Dobson P, Dunn WB, Arga KY, Arvas M, Blüthgen N, Borger S, Costenoble R, Heinemann M, Hucka M, Le Novère N, Li P, Liebermeister W, Mo ML, ... ... Palsson BØ, et al. A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nature Biotechnology. 26: 1155-60. PMID 18846089 DOI: 10.1038/nbt1492  1
2008 Nogales J, Palsson BØ, Thiele I. A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: iJN746 as a cell factory. Bmc Systems Biology. 2: 79. PMID 18793442 DOI: 10.1186/1752-0509-2-79  1
2008 Jamshidi N, Palsson BØ. Top-down analysis of temporal hierarchy in biochemical reaction networks. Plos Computational Biology. 4: e1000177. PMID 18787685 DOI: 10.1371/journal.pcbi.1000177  1
2008 Lee J, Yun H, Feist AM, Palsson BØ, Lee SY. Genome-scale reconstruction and in silico analysis of the Clostridium acetobutylicum ATCC 824 metabolic network. Applied Microbiology and Biotechnology. 80: 849-62. PMID 18758767 DOI: 10.1007/s00253-008-1654-4  1
2008 Shlomi T, Cabili MN, Herrgård MJ, Palsson BØ, Ruppin E. Network-based prediction of human tissue-specific metabolism. Nature Biotechnology. 26: 1003-10. PMID 18711341 DOI: 10.1038/nbt.1487  1
2008 Feist AM, Palsson BØ. The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli. Nature Biotechnology. 26: 659-67. PMID 18536691 DOI: 10.1038/nbt1401  1
2008 Applebee MK, Herrgård MJ, Palsson BØ. Impact of individual mutations on increased fitness in adaptively evolved strains of Escherichia coli. Journal of Bacteriology. 190: 5087-94. PMID 18487343 DOI: 10.1128/JB.01976-07  1
2008 Becker SA, Palsson BO. Context-specific metabolic networks are consistent with experiments. Plos Computational Biology. 4: e1000082. PMID 18483554 DOI: 10.1371/journal.pcbi.1000082  1
2008 Joyce AR, Palsson BØ. Predicting gene essentiality using genome-scale in silico models. Methods in Molecular Biology (Clifton, N.J.). 416: 433-57. PMID 18392986 DOI: 10.1007/978-1-59745-321-9_30  1
2008 Cho BK, Knight EM, Palsson BØ. Genomewide identification of protein binding locations using chromatin immunoprecipitation coupled with microarray. Methods in Molecular Biology (Clifton, N.J.). 439: 131-45. PMID 18370100 DOI: 10.1007/978-1-59745-188-8_9  1
2008 Cho BK, Knight EM, Barrett CL, Palsson BØ. Genome-wide analysis of Fis binding in Escherichia coli indicates a causative role for A-/AT-tracts. Genome Research. 18: 900-10. PMID 18340041 DOI: 10.1101/gr.070276.107  1
2008 Jamshidi N, Palsson BØ. Formulating genome-scale kinetic models in the post-genome era. Molecular Systems Biology. 4: 171. PMID 18319723 DOI: 10.1038/msb.2008.8  1
2008 Becker SA, Palsson BO. Three factors underlying incorrect in silico predictions of essential metabolic genes. Bmc Systems Biology. 2: 14. PMID 18248675 DOI: 10.1186/1752-0509-2-14  1
2008 Reed JL, Hua Q, Palsson BO. Determining metabolic fluxes using experimental measurements Aiche Annual Meeting, Conference Proceedings 1
2007 Resendis-Antonio O, Reed JL, Encarnación S, Collado-Vides J, Palsson BØ. Metabolic reconstruction and modeling of nitrogen fixation in Rhizobium etli. Plos Computational Biology. 3: 1887-95. PMID 17922569 DOI: 10.1371/journal.pcbi.0030192  1
2007 Yeung M, Thiele I, Palsson BO. Estimation of the number of extreme pathways for metabolic networks. Bmc Bioinformatics. 8: 363. PMID 17897474 DOI: 10.1186/1471-2105-8-363  1
2007 Shlomi T, Herrgard M, Portnoy V, Naim E, Palsson BØ, Sharan R, Ruppin E. Systematic condition-dependent annotation of metabolic genes. Genome Research. 17: 1626-33. PMID 17895423 DOI: 10.1101/gr.6678707  1
2007 Cho BK, Charusanti P, Herrgård MJ, Palsson BO. Microbial regulatory and metabolic networks. Current Opinion in Biotechnology. 18: 360-4. PMID 17719767 DOI: 10.1016/j.copbio.2007.07.002  0.92
2007 Mo ML, Jamshidi N, Palsson BØ. A genome-scale, constraint-based approach to systems biology of human metabolism. Molecular Biosystems. 3: 598-603. PMID 17700859 DOI: 10.1039/b705597h  1
2007 Herring CD, Palsson BØ. An evaluation of Comparative Genome Sequencing (CGS) by comparing two previously-sequenced bacterial genomes. Bmc Genomics. 8: 274. PMID 17697331 DOI: 10.1186/1471-2164-8-274  0.6
2007 Feist AM, Henry CS, Reed JL, Krummenacker M, Joyce AR, Karp PD, Broadbelt LJ, Hatzimanikatis V, Palsson BØ. A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information. Molecular Systems Biology. 3: 121. PMID 17593909 DOI: 10.1038/msb4100155  1
2007 Oh YK, Palsson BO, Park SM, Schilling CH, Mahadevan R. Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data. The Journal of Biological Chemistry. 282: 28791-9. PMID 17573341 DOI: 10.1074/jbc.M703759200  1
2007 Jamshidi N, Vo TD, Palsson BO. In silico analysis of SNPs and other high-throughput data. Methods in Molecular Biology (Clifton, N.J.). 366: 267-85. PMID 17568130 DOI: 10.1007/978-1-59745-030-0_15  1
2007 Jamshidi N, Palsson BØ. Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets. Bmc Systems Biology. 1: 26. PMID 17555602 DOI: 10.1186/1752-0509-1-26  1
2007 Hua Q, Joyce AR, Palsson BØ, Fong SS. Metabolic characterization of Escherichia coli strains adapted to growth on lactate. Applied and Environmental Microbiology. 73: 4639-47. PMID 17513588 DOI: 10.1128/AEM.00527-07  1
2007 Anderson MJ, DeLabarre B, Raghunathan A, Palsson BO, Brunger AT, Quake SR. Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices. Biochemistry. 46: 5722-31. PMID 17441732 DOI: 10.1021/bi700096p  1
2007 Becker SA, Feist AM, Mo ML, Hannum G, Palsson BØ, Herrgard MJ. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox. Nature Protocols. 2: 727-38. PMID 17406635 DOI: 10.1038/nprot.2007.99  1
2007 Vo TD, Paul Lee WN, Palsson BO. Systems analysis of energy metabolism elucidates the affected respiratory chain complex in Leigh's syndrome. Molecular Genetics and Metabolism. 91: 15-22. PMID 17336115 DOI: 10.1016/j.ymgme.2007.01.012  1
2007 Duarte NC, Becker SA, Jamshidi N, Thiele I, Mo ML, Vo TD, Srivas R, Palsson BØ. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proceedings of the National Academy of Sciences of the United States of America. 104: 1777-82. PMID 17267599 DOI: 10.1073/pnas.0610772104  1
2007 Joyce AR, Palsson BO. Toward whole cell modeling and simulation: comprehensive functional genomics through the constraint-based approach. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 64: 265, 267-309. PMID 17195479 DOI: 10.1007/978-3-7643-7567-6_11  1
2007 Vo TD, Palsson BO. Building the power house: recent advances in mitochondrial studies through proteomics and systems biology. American Journal of Physiology. Cell Physiology. 292: C164-77. PMID 16885397 DOI: 10.1152/ajpcell.00193.2006  1
2007 Thiele I, Palsson BO. Bringing genomes to life: The use of genome-scale in silico models Introduction to Systems Biology. 14-36. DOI: 10.1007/978-1-59745-531-2_2  1
2006 Reed JL, Patel TR, Chen KH, Joyce AR, Applebee MK, Herring CD, Bui OT, Knight EM, Fong SS, Palsson BO. Systems approach to refining genome annotation. Proceedings of the National Academy of Sciences of the United States of America. 103: 17480-4. PMID 17088549 DOI: 10.1073/pnas.0603364103  1
2006 Herring CD, Raghunathan A, Honisch C, Patel T, Applebee MK, Joyce AR, Albert TJ, Blattner FR, van den Boom D, Cantor CR, Palsson BØ. Comparative genome sequencing of Escherichia coli allows observation of bacterial evolution on a laboratory timescale. Nature Genetics. 38: 1406-12. PMID 17086184 DOI: 10.1038/ng1906  1
2006 Joyce AR, Reed JL, White A, Edwards R, Osterman A, Baba T, Mori H, Lesely SA, Palsson BØ, Agarwalla S. Experimental and computational assessment of conditionally essential genes in Escherichia coli. Journal of Bacteriology. 188: 8259-71. PMID 17012394 DOI: 10.1128/JB.00740-06  1
2006 Barrett CL, Kim TY, Kim HU, Palsson BØ, Lee SY. Systems biology as a foundation for genome-scale synthetic biology. Current Opinion in Biotechnology. 17: 488-92. PMID 16934450 DOI: 10.1016/j.copbio.2006.08.001  1
2006 Gianchandani EP, Papin JA, Price ND, Joyce AR, Palsson BO. Matrix formalism to describe functional states of transcriptional regulatory systems. Plos Computational Biology. 2: e101. PMID 16895435 DOI: 10.1371/journal.pcbi.0020101  1
2006 Vo TD, Palsson BO. Isotopomer analysis of myocardial substrate metabolism: a systems biology approach. Biotechnology and Bioengineering. 95: 972-83. PMID 16878330 DOI: 10.1002/bit.21063  1
2006 Cho BK, Knight EM, Palsson BØ. Transcriptional regulation of the fad regulon genes of Escherichia coli by ArcA. Microbiology (Reading, England). 152: 2207-19. PMID 16849788 DOI: 10.1099/mic.0.28912-0  0.92
2006 Herrgård MJ, Fong SS, Palsson BØ. Identification of genome-scale metabolic network models using experimentally measured flux profiles. Plos Computational Biology. 2: e72. PMID 16839195 DOI: 10.1371/journal.pcbi.0020072  1
2006 Jamshidi N, Palsson BØ. Systems biology of SNPs. Molecular Systems Biology. 2: 38. PMID 16820779 DOI: 10.1038/msb4100077  1
2006 Hua Q, Joyce AR, Fong SS, Palsson BØ. Metabolic analysis of adaptive evolution for in silico-designed lactate-producing strains. Biotechnology and Bioengineering. 95: 992-1002. PMID 16807925 DOI: 10.1002/bit.21073  1
2006 Feist AM, Scholten JC, Palsson BØ, Brockman FJ, Ideker T. Modeling methanogenesis with a genome-scale metabolic reconstruction of Methanosarcina barkeri. Molecular Systems Biology. 2: 2006.0004. PMID 16738551 DOI: 10.1038/msb4100046  1
2006 Barrett CL, Palsson BO. Iterative reconstruction of transcriptional regulatory networks: an algorithmic approach. Plos Computational Biology. 2: e52. PMID 16710450 DOI: 10.1371/journal.pcbi.0020052  1
2006 Herrgård MJ, Lee BS, Portnoy V, Palsson BØ. Integrated analysis of regulatory and metabolic networks reveals novel regulatory mechanisms in Saccharomyces cerevisiae. Genome Research. 16: 627-35. PMID 16606697 DOI: 10.1101/gr.4083206  1
2006 Price ND, Thiele I, Palsson BØ. Candidate states of Helicobacter pylori's genome-scale metabolic network upon application of "loop law" thermodynamic constraints. Biophysical Journal. 90: 3919-28. PMID 16533855 DOI: 10.1529/biophysj.105.072645  1
2006 Jamshidi N, Palsson BØ. Systems biology of the human red blood cell. Blood Cells, Molecules & Diseases. 36: 239-47. PMID 16533612 DOI: 10.1016/j.bcmd.2006.01.006  1
2006 Barrett CL, Price ND, Palsson BO. Network-level analysis of metabolic regulation in the human red blood cell using random sampling and singular value decomposition. Bmc Bioinformatics. 7: 132. PMID 16533395 DOI: 10.1186/1471-2105-7-132  1
2006 Clark IB, Hanania EG, Stevens J, Gallina M, Fieck A, Brandes R, Palsson BO, Koller MR. Optoinjection for efficient targeted delivery of a broad range of compounds and macromolecules into diverse cell types. Journal of Biomedical Optics. 11: 014034. PMID 16526911 DOI: 10.1117/1.2168148  0.4
2006 Becker SA, Price ND, Palsson BØ. Metabolite coupling in genome-scale metabolic networks. Bmc Bioinformatics. 7: 111. PMID 16519800 DOI: 10.1186/1471-2105-7-111  1
2006 Joyce AR, Palsson BØ. The model organism as a system: integrating 'omics' data sets. Nature Reviews. Molecular Cell Biology. 7: 198-210. PMID 16496022 DOI: 10.1038/nrm1857  1
2006 Mahadevan R, Bond DR, Butler JE, Esteve-Nuñez A, Coppi MV, Palsson BO, Schilling CH, Lovley DR. Characterization of metabolism in the Fe(III)-reducing organism Geobacter sulfurreducens by constraint-based modeling. Applied and Environmental Microbiology. 72: 1558-68. PMID 16461711 DOI: 10.1128/AEM.72.2.1558-1568.2006  1
2006 Cho BK, Knight EM, Palsson BO. PCR-based tandem epitope tagging system for Escherichia coli genome engineering. Biotechniques. 40: 67-72. PMID 16454042  0.92
2006 Reed JL, Famili I, Thiele I, Palsson BO. Towards multidimensional genome annotation. Nature Reviews. Genetics. 7: 130-41. PMID 16418748 DOI: 10.1038/nrg1769  1
2006 Allen TE, Price ND, Joyce AR, Palsson BØ. Long-range periodic patterns in microbial genomes indicate significant multi-scale chromosomal organization. Plos Computational Biology. 2: e2. PMID 16410829 DOI: 10.1371/journal.pcbi.0020002  1
2006 Fong SS, Nanchen A, Palsson BO, Sauer U. Latent pathway activation and increased pathway capacity enable Escherichia coli adaptation to loss of key metabolic enzymes. The Journal of Biological Chemistry. 281: 8024-33. PMID 16319065 DOI: 10.1074/jbc.M510016200  1
2006 Vo TD, Lim SK, Lee WNP, Palsson BO. Isotopomer analysis of cellular metabolism in tissue culture: A comparative study between the pathway and network-based methods Metabolomics. 2: 243-256. DOI: 10.1007/s11306-006-0033-3  1
2005 Fong SS, Joyce AR, Palsson BØ. The econometrics of evolution. Nature Chemical Biology. 1: 191-2. PMID 16408032 DOI: 10.1038/nchembio0905-191  1
2005 Barrett CL, Herring CD, Reed JL, Palsson BO. The global transcriptional regulatory network for metabolism in Escherichia coli exhibits few dominant functional states. Proceedings of the National Academy of Sciences of the United States of America. 102: 19103-8. PMID 16357206 DOI: 10.1073/pnas.0505231102  1
2005 Fong SS, Joyce AR, Palsson BØ. Parallel adaptive evolution cultures of Escherichia coli lead to convergent growth phenotypes with different gene expression states. Genome Research. 15: 1365-72. PMID 16204189 DOI: 10.1101/gr.3832305  1
2005 Herring CD, Raffaelle M, Allen TE, Kanin EI, Landick R, Ansari AZ, Palsson BØ. Immobilization of Escherichia coli RNA polymerase and location of binding sites by use of chromatin immunoprecipitation and microarrays. Journal of Bacteriology. 187: 6166-74. PMID 16109958 DOI: 10.1128/JB.187.17.6166-6174.2005  1
2005 Thiele I, Vo TD, Price ND, Palsson BØ. Expanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants. Journal of Bacteriology. 187: 5818-30. PMID 16077130 DOI: 10.1128/JB.187.16.5818-5830.2005  1
2005 Herrgård MJ, Palsson BØ. Untangling the web of functional and physical interactions in yeast. Journal of Biology. 4: 5. PMID 15982410 DOI: 10.1186/jbiol26  0.88
2005 Fong SS, Burgard AP, Herring CD, Knight EM, Blattner FR, Maranas CD, Palsson BO. In silico design and adaptive evolution of Escherichia coli for production of lactic acid Biotechnology and Bioengineering. 91: 643-648. PMID 15962337 DOI: 10.1002/bit.20542  1
2005 Hanania EG, Fieck A, Stevens J, Bodzin LJ, Palsson BØ, Koller MR. Automated in situ measurement of cell-specific antibody secretion and laser-mediated purification for rapid cloning of highly-secreting producers. Biotechnology and Bioengineering. 91: 872-6. PMID 15937942 DOI: 10.1002/bit.20559  0.4
2005 Becker SA, Palsson BØ. Genome-scale reconstruction of the metabolic network in Staphylococcus aureus N315: an initial draft to the two-dimensional annotation. Bmc Microbiology. 5: 8. PMID 15752426 DOI: 10.1186/1471-2180-5-8  1
2005 Papin JA, Hunter T, Palsson BO, Subramaniam S. Reconstruction of cellular signalling networks and analysis of their properties. Nature Reviews. Molecular Cell Biology. 6: 99-111. PMID 15654321 DOI: 10.1038/nrm1570  1
2005 Famili I, Mahadevan R, Palsson BO. k-Cone analysis: determining all candidate values for kinetic parameters on a network scale. Biophysical Journal. 88: 1616-25. PMID 15626710 DOI: 10.1529/biophysj.104.050385  1
2005 Bell SL, Palsson BØ. Expa: a program for calculating extreme pathways in biochemical reaction networks. Bioinformatics (Oxford, England). 21: 1739-40. PMID 15613397 DOI: 10.1093/bioinformatics/bti228  1
2005 Mahadevan R, Palsson BO. Properties of metabolic networks: structure versus function. Biophysical Journal. 88: L07-9. PMID 15574705 DOI: 10.1529/biophysj.104.055723  1
2005 Thiele I, Price ND, Vo TD, Palsson BØ. Candidate metabolic network states in human mitochondria. Impact of diabetes, ischemia, and diet. The Journal of Biological Chemistry. 280: 11683-95. PMID 15572364 DOI: 10.1074/jbc.M409072200  1
2004 Honisch C, Raghunathan A, Cantor CR, Palsson BØ, van den Boom D. High-throughput mutation detection underlying adaptive evolution of Escherichia coli-K12. Genome Research. 14: 2495-502. PMID 15574828 DOI: 10.1101/gr.2977704  1
2004 Papin JA, Reed JL, Palsson BO. Hierarchical thinking in network biology: the unbiased modularization of biochemical networks. Trends in Biochemical Sciences. 29: 641-7. PMID 15544950 DOI: 10.1016/j.tibs.2004.10.001  1
2004 Price ND, Reed JL, Palsson BØ. Genome-scale models of microbial cells: evaluating the consequences of constraints. Nature Reviews. Microbiology. 2: 886-97. PMID 15494745 DOI: 10.1038/nrmicro1023  1
2004 Westerhoff HV, Palsson BO. The evolution of molecular biology into systems biology. Nature Biotechnology. 22: 1249-52. PMID 15470464 DOI: 10.1038/nbt1020  1
2004 Price ND, Schellenberger J, Palsson BO. Uniform sampling of steady-state flux spaces: means to design experiments and to interpret enzymopathies. Biophysical Journal. 87: 2172-86. PMID 15454420 DOI: 10.1529/biophysj.104.043000  1
2004 Fong SS, Palsson BØ. Metabolic gene-deletion strains of Escherichia coli evolve to computationally predicted growth phenotypes. Nature Genetics. 36: 1056-8. PMID 15448692 DOI: 10.1038/ng1432  1
2004 Koller MR, Hanania EG, Stevens J, Eisfeld TM, Sasaki GC, Fieck A, Palsson BØ. High-throughput laser-mediated in situ cell purification with high purity and yield. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 61: 153-61. PMID 15382147 DOI: 10.1002/cyto.a.20079  0.4
2004 Duarte NC, Palsson BØ, Fu P. Integrated analysis of metabolic phenotypes in Saccharomyces cerevisiae. Bmc Genomics. 5: 63. PMID 15355549 DOI: 10.1186/1471-2164-5-63  0.8
2004 Reed JL, Palsson BØ. Genome-scale in silico models of E. coli have multiple equivalent phenotypic states: assessment of correlated reaction subsets that comprise network states. Genome Research. 14: 1797-805. PMID 15342562 DOI: 10.1101/gr.2546004  1
2004 Papin JA, Stelling J, Price ND, Klamt S, Schuster S, Palsson BO. Comparison of network-based pathway analysis methods. Trends in Biotechnology. 22: 400-5. PMID 15283984 DOI: 10.1016/j.tibtech.2004.06.010  1
2004 Papin JA, Palsson BO. The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis. Biophysical Journal. 87: 37-46. PMID 15240442 DOI: 10.1529/biophysj.103.029884  1
2004 Vo TD, Greenberg HJ, Palsson BO. Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical data. The Journal of Biological Chemistry. 279: 39532-40. PMID 15205464 DOI: 10.1074/jbc.M403782200  1
2004 Duarte NC, Herrgård MJ, Palsson BØ. Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model. Genome Research. 14: 1298-309. PMID 15197165 DOI: 10.1101/gr.2250904  0.88
2004 Herrgård MJ, Palsson BØ. Flagellar biosynthesis in silico: building quantitative models of regulatory networks. Cell. 117: 689-90. PMID 15186769 DOI: 10.1016/j.cell.2004.05.020  0.88
2004 Wiback SJ, Famili I, Greenberg HJ, Palsson BØ. Monte Carlo sampling can be used to determine the size and shape of the steady-state flux space. Journal of Theoretical Biology. 228: 437-47. PMID 15178193 DOI: 10.1016/j.jtbi.2004.02.006  1
2004 Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO. Integrating high-throughput and computational data elucidates bacterial networks. Nature. 429: 92-6. PMID 15129285 DOI: 10.1038/nature02456  1
2004 Raghunathan A, Price ND, Galperin MY, Makarova KS, Purvine S, Picone AF, Cherny T, Xie T, Reilly TJ, Munson R, Tyler RE, Akerley BJ, Smith AL, Palsson BO, Kolker E. In Silico Metabolic Model and Protein Expression of Haemophilus influenzae Strain Rd KW20 in Rich Medium. Omics : a Journal of Integrative Biology. 8: 25-41. PMID 15107235 DOI: 10.1089/153623104773547471  1
2004 Herrgård MJ, Covert MW, Palsson BØ. Reconstruction of microbial transcriptional regulatory networks. Current Opinion in Biotechnology. 15: 70-7. PMID 15102470 DOI: 10.1016/j.copbio.2003.11.002  1
2004 Palsson BØ. In silico biotechnology. Era of reconstruction and interrogation. Current Opinion in Biotechnology. 15: 50-1. PMID 15102466 DOI: 10.1016/j.copbio.2004.01.006  0.68
2004 Wiback SJ, Mahadevan R, Palsson BØ. Using metabolic flux data to further constrain the metabolic solution space and predict internal flux patterns: the Escherichia coli spectrum. Biotechnology and Bioengineering. 86: 317-31. PMID 15083512 DOI: 10.1002/bit.20011  1
2004 Papin JA, Palsson BO. Topological analysis of mass-balanced signaling networks: a framework to obtain network properties including crosstalk. Journal of Theoretical Biology. 227: 283-97. PMID 14990392 DOI: 10.1016/j.jtbi.2003.11.016  1
2003 Ibarra RU, Fu P, Palsson BO, DiTonno JR, Edwards JS. Quantitative analysis of Escherichia coli metabolic phenotypes within the context of phenotypic phase planes. Journal of Molecular Microbiology and Biotechnology. 6: 101-8. PMID 15044828  1
2003 Covert MW, Famili I, Palsson BO. Identifying constraints that govern cell behavior: a key to converting conceptual to computational models in biology? Biotechnology and Bioengineering. 84: 763-72. PMID 14708117 DOI: 10.1002/bit.10849  1
2003 Famili I, Forster J, Nielsen J, Palsson BO. Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network. Proceedings of the National Academy of Sciences of the United States of America. 100: 13134-9. PMID 14578455 DOI: 10.1073/pnas.2235812100  1
2003 Price ND, Reed JL, Papin JA, Wiback SJ, Palsson BO. Network-based analysis of metabolic regulation in the human red blood cell. Journal of Theoretical Biology. 225: 185-94. PMID 14575652 DOI: 10.1016/S0022-5193(03)00237-6  1
2003 Fong SS, Marciniak JY, Palsson BØ. Description and interpretation of adaptive evolution of Escherichia coli K-12 MG1655 by using a genome-scale in silico metabolic model. Journal of Bacteriology. 185: 6400-8. PMID 14563875 DOI: 10.1128/JB.185.21.6400-6408.2003  1
2003 Allen TE, Herrgård MJ, Liu M, Qiu Y, Glasner JD, Blattner FR, Palsson BØ. Genome-scale analysis of the uses of the Escherichia coli genome: model-driven analysis of heterogeneous data sets. Journal of Bacteriology. 185: 6392-9. PMID 14563874 DOI: 10.1128/JB.185.21.6392-6399.2003  1
2003 Herrgård MJ, Covert MW, Palsson BØ. Reconciling gene expression data with known genome-scale regulatory network structures. Genome Research. 13: 2423-34. PMID 14559784 DOI: 10.1101/gr.1330003  1
2003 Förster J, Famili I, Palsson BO, Nielsen J. Large-scale evaluation of in silico gene deletions in Saccharomyces cerevisiae. Omics : a Journal of Integrative Biology. 7: 193-202. PMID 14506848  1
2003 Reed JL, Vo TD, Schilling CH, Palsson BO. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Genome Biology. 4: R54. PMID 12952533 DOI: 10.1186/gb-2003-4-9-r54  1
2003 Wiback SJ, Mahadevan R, Palsson BØ. Reconstructing metabolic flux vectors from extreme pathways: defining the alpha-spectrum. Journal of Theoretical Biology. 224: 313-24. PMID 12941590 DOI: 10.1016/S0022-5193(03)00168-1  1
2003 Famili I, Palsson BO. Systemic metabolic reactions are obtained by singular value decomposition of genome-scale stoichiometric matrices. Journal of Theoretical Biology. 224: 87-96. PMID 12900206 DOI: 10.1016/S0022-5193(03)00146-2  1
2003 Raghunathan A, Palsson BO. Scalable method to determine mutations that occur during adaptive evolution of Escherichia coli. Biotechnology Letters. 25: 435-41. PMID 12882568 DOI: 10.1023/A:1022497310798  1
2003 Kolker E, Purvine S, Galperin MY, Stolyar S, Goodlett DR, Nesvizhskii AI, Keller A, Xie T, Eng JK, Yi E, Hood L, Picone AF, Cherny T, Tjaden BC, Siegel AF, ... ... Palsson BO, et al. Initial proteome analysis of model microorganism Haemophilus influenzae strain Rd KW20. Journal of Bacteriology. 185: 4593-602. PMID 12867470 DOI: 10.1128/JB.185.15.4593-4602.2003  1
2003 Famili I, Palsson BO. The convex basis of the left null space of the stoichiometric matrix leads to the definition of metabolically meaningful pools. Biophysical Journal. 85: 16-26. PMID 12829460 DOI: 10.1016/S0006-3495(03)74450-6  1
2003 Papin JA, Price ND, Wiback SJ, Fell DA, Palsson BO. Metabolic pathways in the post-genome era. Trends in Biochemical Sciences. 28: 250-8. PMID 12765837 DOI: 10.1016/S0968-0004(03)00064-1  1
2003 Palsson BO, Price ND, Papin JA. Development of network-based pathway definitions: the need to analyze real metabolic networks. Trends in Biotechnology. 21: 195-8. PMID 12727379 DOI: 10.1016/S0167-7799(03)00080-5  1
2003 Reed JL, Palsson BØ. Thirteen years of building constraint-based in silico models of Escherichia coli. Journal of Bacteriology. 185: 2692-9. PMID 12700248 DOI: 10.1128/JB.185.9.2692-2699.2003  1
2003 Price ND, Papin JA, Schilling CH, Palsson BO. Genome-scale microbial in silico models: the constraints-based approach. Trends in Biotechnology. 21: 162-9. PMID 12679064 DOI: 10.1016/S0167-7799(03)00030-1  1
2003 Covert MW, Palsson BO. Constraints-based models: regulation of gene expression reduces the steady-state solution space. Journal of Theoretical Biology. 221: 309-25. PMID 12642111 DOI: 10.1006/jtbi.2003.3071  1
2003 Förster J, Famili I, Fu P, Palsson BØ, Nielsen J. Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Research. 13: 244-53. PMID 12566402 DOI: 10.1101/gr.234503  1
2003 Price ND, Reed JL, Papin JA, Famili I, Palsson BO. Analysis of metabolic capabilities using singular value decomposition of extreme pathway matrices. Biophysical Journal. 84: 794-804. PMID 12547764 DOI: 10.1016/S0006-3495(03)74899-1  1
2003 Allen TE, Palsson BØ. Sequence-based analysis of metabolic demands for protein synthesis in prokaryotes. Journal of Theoretical Biology. 220: 1-18. PMID 12453446 DOI: 10.1006/jtbi.2003.3087  1
2002 Kolker E, Purvine S, Picone A, Cherny T, Akerley BJ, Munson RS, Palsson BO, Daines DA, Smith AL. H. influenzae Consortium: integrative study of H. influenzae-human interactions. Omics : a Journal of Integrative Biology. 6: 341-8. PMID 12626093 DOI: 10.1089/153623102321112764  1
2002 Papin JA, Price ND, Palsson BØ. Extreme pathway lengths and reaction participation in genome-scale metabolic networks. Genome Research. 12: 1889-900. PMID 12466293 DOI: 10.1101/gr.327702  1
2002 Ibarra RU, Edwards JS, Palsson BO. Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature. 420: 186-9. PMID 12432395 DOI: 10.1038/nature01149  1
2002 Price ND, Famili I, Beard DA, Palsson BØ. Extreme pathways and Kirchhoff's second law. Biophysical Journal. 83: 2879-82. PMID 12425318 DOI: 10.1016/S0006-3495(02)75297-1  1
2002 Schilling CH, Covert MW, Famili I, Church GM, Edwards JS, Palsson BO. Genome-scale metabolic model of Helicobacter pylori 26695. Journal of Bacteriology. 184: 4582-93. PMID 12142428 DOI: 10.1128/JB.184.16.4582-4593.2002  1
2002 Wiback SJ, Palsson BO. Extreme pathway analysis of human red blood cell metabolism. Biophysical Journal. 83: 808-18. PMID 12124266 DOI: 10.1016/S0006-3495(02)75210-7  1
2002 Kauffman KJ, Pajerowski JD, Jamshidi N, Palsson BO, Edwards JS. Description and analysis of metabolic connectivity and dynamics in the human red blood cell. Biophysical Journal. 83: 646-62. PMID 12124254 DOI: 10.1016/S0006-3495(02)75198-9  1
2002 Covert MW, Palsson BØ. Transcriptional regulation in constraints-based metabolic models of Escherichia coli. The Journal of Biological Chemistry. 277: 28058-64. PMID 12006566 DOI: 10.1074/jbc.M201691200  1
2002 Price ND, Papin JA, Palsson BØ. Determination of redundancy and systems properties of the metabolic network of Helicobacter pylori using genome-scale extreme pathway analysis. Genome Research. 12: 760-9. PMID 11997342 DOI: 10.1101/gr.218002. Article published online before print in April 2002  1
2002 Lee GM, Fong SS, Oh DJ, Francis K, Palsson BO. Characterization and efficacy of PKH26 as a probe to study the replication history of the human hematopoietic KG1a progenitor cell line. In Vitro Cellular & Developmental Biology. Animal. 38: 90-6. PMID 11929001 DOI: 10.1290/1071-2690(2002)038<0090:CAEOPA>2.0.CO;2  1
2002 Edwards JS, Ramakrishna R, Palsson BO. Characterizing the metabolic phenotype: a phenotype phase plane analysis. Biotechnology and Bioengineering. 77: 27-36. PMID 11745171 DOI: 10.1002/bit.10047  1
2001 Jamshidi N, Edwards JS, Fahland T, Church GM, Palsson BO. Dynamic simulation of the human red blood cell metabolic network. Bioinformatics (Oxford, England). 17: 286-7. PMID 11294796  1
2001 Covert MW, Schilling CH, Famili I, Edwards JS, Goryanin II, Selkov E, Palsson BO. Metabolic modeling of microbial strains in silico. Trends in Biochemical Sciences. 26: 179-86. PMID 11246024 DOI: 10.1016/S0968-0004(00)01754-0  1
2001 Edwards JS, Ibarra RU, Palsson BO. In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nature Biotechnology. 19: 125-30. PMID 11175725 DOI: 10.1038/84379  1
2001 Ramakrishna R, Edwards JS, McCulloch A, Palsson BO. Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 280: R695-704. PMID 11171647  1
2000 Schilling CH, Edwards JS, Letscher D, Palsson BØ. Combining pathway analysis with flux balance analysis for the comprehensive study of metabolic systems. Biotechnology and Bioengineering. 71: 286-306. PMID 11291038 DOI: 10.1002/1097-0290(2000)71:4<286::AID-BIT1018>3.0.CO;2-R  1
2000 Edwards JS, Palsson BO. Robustness analysis of the Escherichia coli metabolic network. Biotechnology Progress. 16: 927-39. PMID 11101318 DOI: 10.1021/bp0000712  1
2000 Edwards JS, Palsson BO. Multiple steady states in kinetic models of red cell metabolism. Journal of Theoretical Biology. 207: 125-7. PMID 11027485 DOI: 10.1006/jtbi.2000.2165  1
2000 Edwards JS, Palsson BO. Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions. Bmc Bioinformatics. 1: 1. PMID 11001586 DOI: 10.1186/1471-2105-1-1  1
2000 Oh DJ, Martinez AR, Lee GM, Francis K, Palsson BO. Intercellular adhesion can be visualized using fluorescently labeled fibrosarcoma HT1080 cells cocultured with hematopoietic cell lines or CD34(+) enriched human mobilized peripheral blood cells. Cytometry. 40: 119-25. PMID 10805931 DOI: 10.1002/(SICI)1097-0320(20000601)40:2<119::AID-CYTO5>3.0.CO;2-P  1
2000 Oh DJ, Martinez AR, Lee GM, Francis K, Palsson BO. Extension of osmolality-induced podia is observed from fluorescently labeled hematopoietic cell lines in hyperosmotic medium. Cytometry. 40: 109-18. PMID 10805930 DOI: 10.1002/(SICI)1097-0320(20000601)40:2<109::AID-CYTO4>3.0.CO;2-V  1
2000 Edwards JS, Palsson BO. The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities. Proceedings of the National Academy of Sciences of the United States of America. 97: 5528-33. PMID 10805808  1
2000 Schilling CH, Palsson BO. Assessment of the metabolic capabilities of Haemophilus influenzae Rd through a genome-scale pathway analysis. Journal of Theoretical Biology. 203: 249-83. PMID 10716908 DOI: 10.1006/jtbi.2000.1088  1
2000 Schilling CH, Letscher D, Palsson BO. Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective. Journal of Theoretical Biology. 203: 229-48. PMID 10716907 DOI: 10.1006/jtbi.2000.1073  1
2000 Lee GM, Fong S, Francis K, Oh DJ, Palsson BO. In situ labeling of adherent cells with PKH26. In Vitro Cellular & Developmental Biology. Animal. 36: 4-6. PMID 10691033 DOI: 10.1290/1071-2690(2000)036<0004:ISLOAC>2.0.CO;2  1
1999 Holloway W, Martinez AR, Oh DJ, Francis K, Ramakrishna R, Palsson BO. Key adhesion molecules are present on long podia extended by hematopoietic cells. Cytometry. 37: 171-7. PMID 10520196 DOI: 10.1002/(SICI)1097-0320(19991101)37:3<171::AID-CYTO2>3.0.CO;2-8  1
1999 Huang S, Law P, Francis K, Palsson BO, Ho AD. Symmetry of initial cell divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules. Blood. 94: 2595-604. PMID 10515863  1
1999 Oh DJ, Lee GM, Francis K, Palsson BO. Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line. Cytometry. 36: 312-8. PMID 10404146 DOI: 10.1002/(SICI)1097-0320(19990801)36:4<312::AID-CYTO5>3.0.CO;2-V  1
1999 Edwards JS, Palsson BO. Systems properties of the Haemophilus influenzae Rd metabolic genotype. The Journal of Biological Chemistry. 274: 17410-6. PMID 10364169  1
1999 Schilling CH, Schuster S, Palsson BO, Heinrich R. Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era. Biotechnology Progress. 15: 296-303. PMID 10356246 DOI: 10.1021/bp990048k  1
1999 Schilling CH, Edwards JS, Palsson BO. Toward metabolic phenomics: analysis of genomic data using flux balances. Biotechnology Progress. 15: 288-95. PMID 10356245 DOI: 10.1021/bp9900357  1
1998 Andreadis S, Fuller AO, Palsson BO. Cell cycle dependence of retroviral transduction: An issue of overlapping time scales. Biotechnology and Bioengineering. 58: 272-81. PMID 10191401 DOI: 10.1002/(SICI)1097-0290(19980420)58:2/3<272::AID-BIT23>3.0.CO;2-D  1
1998 Edwards JS, Palsson BO. How will bioinformatics influence metabolic engineering? Biotechnology and Bioengineering. 58: 162-9. PMID 10191386 DOI: 10.1002/(SICI)1097-0290(19980420)58:2/3<162::AID-BIT8>3.0.CO;2-J  1
1998 Mandalam RK, Palsson BO. Elemental balancing of biomass and medium composition enhances growth capacity in high-density Chlorella vulgaris cultures. Biotechnology and Bioengineering. 59: 605-11. PMID 10099378 DOI: 10.1002/(SICI)1097-0290(19980905)59:5<605::AID-BIT11>3.0.CO;2-8  1
1998 Koller MR, Palsson MA, Manchel I, Maher RJ, Palsson BO. Tissue culture surface characteristics influence the expansion of human bone marrow cells. Biomaterials. 19: 1963-72. PMID 9863530  1
1998 Francis K, Ramakrishna R, Holloway W, Palsson BO. Two new pseudopod morphologies displayed by the human hematopoietic KG1a progenitor cell line and by primary human CD34(+) cells. Blood. 92: 3616-23. PMID 9808555  1
1998 Schilling CH, Palsson BO. The underlying pathway structure of biochemical reaction networks. Proceedings of the National Academy of Sciences of the United States of America. 95: 4193-8. PMID 9539712 DOI: 10.1073/pnas.95.8.4193  1
1997 Francis K, Palsson BO. Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion. Proceedings of the National Academy of Sciences of the United States of America. 94: 12258-62. PMID 9356436 DOI: 10.1073/pnas.94.23.12258  1
1997 Andreadis ST, Brott D, Fuller AO, Palsson BO. Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours. Journal of Virology. 71: 7541-8. PMID 9311834  1
1997 Koller MR, Manchel I, Palsson BO. Importance of parenchymal:stromal cell ratio for the ex vivo reconstitution of human hematopoiesis. Stem Cells (Dayton, Ohio). 15: 305-13. PMID 9253115 DOI: 10.1002/stem.150305  0.4
1997 Andreadis S, Palsson BO. Coupled effects of polybrene and calf serum on the efficiency of retroviral transduction and the stability of retroviral vectors. Human Gene Therapy. 8: 285-91. PMID 9048195 DOI: 10.1089/hum.1997.8.3-285  1
1996 Shen BQ, Clarke MF, Palsson BO. Kinetics of retroviral production from the amphotropic ΨCRIP murine producer cell line. Cytotechnology. 22: 185-95. PMID 22358929 DOI: 10.1007/BF00353938  0.4
1996 Peng CA, Koller MR, Palsson BØ. Unilineage model of hematopoiesis predicts self-renewal of stem and progenitor cells based on ex vivo growth data. Biotechnology and Bioengineering. 52: 24-33. PMID 18629849 DOI: 10.1002/(SICI)1097-0290(19961005)52:1<24::AID-BIT3>3.0.CO;2-0  1
1996 Koller MR, Manchel I, Palsson MA, Maher RJ, Palsson BØ. Different measures of human hematopoietic cell culture performance are optimized under vastly different conditions. Biotechnology and Bioengineering. 50: 505-13. PMID 18627012 DOI: 10.1002/(SICI)1097-0290(19960605)50:5<505::AID-BIT4>3.0.CO;2-J  0.4
1996 Peng CA, Palsson BØ. Cell growth and differentiation on feeder layers is predicted to be influenced by bioreactor geometry. Biotechnology and Bioengineering. 50: 479-92. PMID 18627010 DOI: 10.1002/(SICI)1097-0290(19960605)50:5<479::AID-BIT2>3.0.CO;2-C  1
1996 Chuck AS, Palsson BØ. Membrane adsorption characteristics determine the kinetics of flow-through transductions. Biotechnology and Bioengineering. 51: 260-70. PMID 18624359 DOI: 10.1002/(SICI)1097-0290(19960805)51:3<260::AID-BIT2>3.0.CO;2-B  1
1996 Koller MR, Manchel I, Brott DA, Palsson Bø. Donor-to-donor variability in the expansion potential of human bone marrow cells is reduced by accessory cells but not by soluble growth factors. Experimental Hematology. 24: 1484-93. PMID 8950231  1
1996 Koller MR, Oxender M, Brott DA, Palsson BO. flt-3 ligand is more potent than c-kit ligand for the synergistic stimulation of ex vivo hematopoietic cell expansion. Journal of Hematotherapy. 5: 449-59. PMID 8938517  1
1996 Chuck AS, Palsson BO. Consistent and high rates of gene transfer can be obtained using flow-through transduction over a wide range of retroviral titers. Human Gene Therapy. 7: 743-50. PMID 8919596 DOI: 10.1089/hum.1996.7.6-743  1
1996 Andreadis ST, Palsson BO. Kinetics of retrovirus mediated gene transfer: the importance of intracellular half-life of retroviruses. Journal of Theoretical Biology. 182: 1-20. PMID 8917734 DOI: 10.1006/jtbi.1996.0140  1
1996 Chuck AS, Clarke MF, Palsson BO. Retroviral infection is limited by Brownian motion. Human Gene Therapy. 7: 1527-34. PMID 8864753 DOI: 10.1089/hum.1996.7.13-1527  1
1996 Peng CA, Palsson BO. Determination of specific oxygen uptake rates in human hematopoietic cultures and implications for bioreactor design. Annals of Biomedical Engineering. 24: 373-81. PMID 8734058 DOI: 10.1007/BF02660886  1
1996 Rogers CE, Bradley MS, Palsson BO, Koller MR. Flow cytometric analysis of human bone marrow perfusion cultures: erythroid development and relationship with burst-forming units-erythroid. Experimental Hematology. 24: 597-604. PMID 8605964  0.4
1995 Palsson BO, Oh DJ, Koller MR. Replating of bioreactor expanded human bone marrow results in extended growth of primitive and mature cells. Cytotechnology. 18: 125-31. PMID 22358645 DOI: 10.1007/BF00744328  0.96
1995 Varma A, Palsson BO. Parametric sensitivity of stoichiometric flux balance models applied to wild-type Escherichia coli metabolism. Biotechnology and Bioengineering. 45: 69-79. PMID 18623053 DOI: 10.1002/bit.260450110  1
1995 Koller MR, Bradley MS, Palsson BO. Growth factor consumption and production in perfusion cultures of human bone marrow correlate with specific cell production. Experimental Hematology. 23: 1275-83. PMID 7589282  0.4
1995 Eipers PG, Krauss JC, Palsson BO, Emerson SG, Todd RF, Clarke MF. Retroviral-mediated gene transfer in human bone marrow cells growth in continuous perfusion culture vessels. Blood. 86: 3754-62. PMID 7579342  1
1995 Emerson SG, Palsson BO, Clarke MF, Silver SM, Adams PT, Koller MR, Van Zant G, Rummel S, Armstrong RD, Maluta J. In vitro expansion of hematopoietic cells for clinical application. Cancer Treatment and Research. 76: 215-23. PMID 7577336  0.64
1995 Koller MR, Manchel I, Newsom BS, Palsson MA, Palsson BO. Bioreactor expansion of human bone marrow: comparison of unprocessed, density-separated, and CD34-enriched cells. Journal of Hematotherapy. 4: 159-69. PMID 7551915  0.4
1995 Koller MR, Palsson MA, Manchel I, Palsson BO. Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects. Blood. 86: 1784-93. PMID 7544642  0.4
1994 Oh DJ, Koller MR, Palsson BO. Frequent harvesting from perfused bone marrow cultures results in increased overall cell and progenitor expansion. Biotechnology and Bioengineering. 44: 609-16. PMID 18618796 DOI: 10.1002/bit.260440507  0.96
1994 Lee CG, Palsson BØ. High-density algal photobioreactors using light-emitting diodes. Biotechnology and Bioengineering. 44: 1161-7. PMID 18618541 DOI: 10.1002/bit.260441002  1
1994 Levee MG, Lee GM, Paek SH, Palsson BO. Microencapsulated human bone marrow cultures: a potential culture system for the clonal outgrowth of hematopoietic progenitor cells. Biotechnology and Bioengineering. 43: 734-9. PMID 18615796 DOI: 10.1002/bit.260430807  1
1994 Varma A, Palsson BO. Predictions for oxygen supply control to enhance population stability of engineered production strains. Biotechnology and Bioengineering. 43: 275-85. PMID 18615690 DOI: 10.1002/bit.260430403  1
1994 Varma A, Palsson BO. Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. Applied and Environmental Microbiology. 60: 3724-31. PMID 7986045  1
1994 Lee GM, Kim SJ, Palsson BO. Enhanced specific antibody productivity of calcium alginate-entrapped hybridoma is cell line-specific. Cytotechnology. 16: 1-15. PMID 7765785  1
1994 Lee GM, Palsson BO. Monoclonal antibody production using free-suspended and entrapped hybridoma cells. Biotechnology & Genetic Engineering Reviews. 12: 509-33. PMID 7727036  1
1993 Varma A, Palsson BO. Metabolic capabilities of Escherichia coli: I. synthesis of biosynthetic precursors and cofactors. Journal of Theoretical Biology. 165: 477-502. PMID 21322280 DOI: 10.1006/jtbi.1993.1202  1
1993 Lee GM, Palsson BO. Stability of antibody productivity is improved when hybridoma cells are entrapped in calcium alginate beads. Biotechnology and Bioengineering. 42: 1131-5. PMID 18613244 DOI: 10.1002/bit.260420917  1
1993 Koller MR, Palsson BO. Review: tissue engineering: reconstitution of human hematopoiesis ex vivo. Biotechnology and Bioengineering. 42: 909-30. PMID 18613140 DOI: 10.1002/bit.260420802  0.4
1993 Merritt SE, Palsson BO. Loss of antibody productivity is highly reproducible in multiple hybridoma subclones. Biotechnology and Bioengineering. 42: 247-50. PMID 18612986 DOI: 10.1002/bit.260420213  1
1993 Varma A, Boesch BW, Palsson BO. Biochemical production capabilities of Escherichia coli. Biotechnology and Bioengineering. 42: 59-73. PMID 18609648 DOI: 10.1002/bit.260420109  1
1993 Lee GM, Chuck AS, Palsson BO. Cell Culture conditions determine the enhancement of specific monoclonal antibody productivity of calcium alginate-entrapped S3H5/gamma2bA2 hybridoma cells. Biotechnology and Bioengineering. 41: 330-40. PMID 18609557 DOI: 10.1002/bit.260410307  1
1993 Meyerhoff ME, Trojanowicz M, Palsson BO. Simultaneous enzymatic/electrochemical determination of glucose and L-glutamine in hybridoma media by flow-injection analysis. Biotechnology and Bioengineering. 41: 964-9. PMID 18601278 DOI: 10.1002/bit.260411007  0.01
1993 Varma A, Boesch BW, Palsson BO. Stoichiometric interpretation of Escherichia coli glucose catabolism under various oxygenation rates. Applied and Environmental Microbiology. 59: 2465-73. PMID 8368835  1
1993 Palsson BO, Lee ID. Model complexity has a significant effect on the numerical value and interpretation of metabolic sensitivity coefficients. Journal of Theoretical Biology. 161: 299-315. PMID 8331956 DOI: 10.1006/jtbi.1993.1057  1
1993 Koller MR, Emerson SG, Palsson BO. Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures. Blood. 82: 378-84. PMID 8329697  0.64
1993 Palsson BO, Paek SH, Schwartz RM, Palsson M, Lee GM, Silver S, Emerson SG. Expansion of human bone marrow progenitor cells in a high cell density continuous perfusion system. Bio/Technology (Nature Publishing Company). 11: 368-72. PMID 7763438 DOI: 10.1038/nbt0393-368  1
1992 Javanmardian M, Palsson BO. Continuous photoautotrophic cultures of the eukaryotic alga Chlorella vulgaris can exhibit stable oscillatory dynamics. Biotechnology and Bioengineering. 39: 487-97. PMID 18600974 DOI: 10.1002/bit.260390503  1
1992 Ozturk SS, Riley MR, Palsson BO. Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production. Biotechnology and Bioengineering. 39: 418-31. PMID 18600963 DOI: 10.1002/bit.260390408  1
1992 Chuck AS, Palsson BO. Population balance between producing and nonproducing hybridoma clones is very sensitive to serum level, state of inoculum, and medium composition. Biotechnology and Bioengineering. 39: 354-60. PMID 18600953 DOI: 10.1002/bit.260390315  1
1992 Javanmardian M, Palsson BøO. Design and operation of an algal photobioreactor system. Advances in Space Research : the Official Journal of the Committee On Space Research (Cospar). 12: 231-5. PMID 11537069 DOI: 10.1016/0273-1177(92)90029-W  1
1992 Keasling JD, Palsson BO, Cooper S. Replication of the R6K plasmid during the Escherichia coli cell cycle. Journal of Bacteriology. 174: 1060-2. PMID 1732198  0.96
1992 Keasling JD, Palsson BO, Cooper S. Replication of prophage P1 is cell-cycle specific. Journal of Bacteriology. 174: 4457-62. PMID 1624438  0.96
1992 Savinell JM, Palsson BO. Network analysis of intermediary metabolism using linear optimization. II. Interpretation of hybridoma cell metabolism. Journal of Theoretical Biology. 154: 455-73. PMID 1593897 DOI: 10.1016/S0022-5193(05)80162-6  1
1992 Savinell JM, Palsson BO. Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism. Journal of Theoretical Biology. 154: 421-54. PMID 1593896 DOI: 10.1016/S0022-5193(05)80161-4  1
1992 Varma A, el-Awar FY, Palsson BO, Emerson SG, Clarke MF. Can Dexter cultures support stem cell proliferation? Experimental Hematology. 20: 87-91. PMID 1577098  1
1992 Keasling JD, Palsson BO, Cooper S. Replication of mini-F plasmids during the bacterial division cycle. Research in Microbiology. 143: 541-8. PMID 1475515  0.96
1992 Lee ID, Palsson BO. A Macintosh software package for simulation of human red blood cell metabolism. Computer Methods and Programs in Biomedicine. 38: 195-226. PMID 1473341 DOI: 10.1016/0169-2607(92)90102-D  1
1992 Savinell JM, Palsson BO. Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism. Journal of Theoretical Biology. 155: 215-42. PMID 1453698 DOI: 10.1016/S0022-5193(05)80596-X  1
1992 Savinell JM, Palsson BO. Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods. Journal of Theoretical Biology. 155: 201-14. PMID 1453697 DOI: 10.1016/S0022-5193(05)80595-8  1
1992 Schwartz RM, Caldwell J, Clarke MF, Emerson SG, Palsson BO. The influence of extra-cellular matrix and stroma remodeling on the productivity of long-term human bone marrow cultures. Cytotechnology. 10: 217-24. PMID 1369237 DOI: 10.1007/BF00146672  1
1991 Lee GM, Varma A, Palsson BO. Production of monoclonal antibody using free-suspended and immobilized hybridoma cells: Effect of serum. Biotechnology and Bioengineering. 38: 821-30. PMID 18600839 DOI: 10.1002/bit.260380804  1
1991 Javanmardian M, Palsson BO. High-density photoautotrophic algal cultures: design, construction, and operation of a novel photobioreactor system. Biotechnology and Bioengineering. 38: 1182-9. PMID 18600714 DOI: 10.1002/bit.260381010  1
1991 Ozturk SS, Palsson BO. Effect of medium osmolarity on hybridoma growth, metabolism, and antibody production. Biotechnology and Bioengineering. 37: 989-93. PMID 18597326 DOI: 10.1002/bit.260371015  1
1991 Ozturk SS, Palsson BO. Physiological changes during the adaptation of hybridoma cells to low serum and serum-free media. Biotechnology and Bioengineering. 37: 35-46. PMID 18597305 DOI: 10.1002/bit.260370107  1
1991 Emerson SG, Palsson BO, Clarke MF. The construction of high efficiency human bone marrow tissue ex vivo. Journal of Cellular Biochemistry. 45: 268-72. PMID 2066377 DOI: 10.1002/jcb.240450308  0.64
1991 Caldwell J, Palsson BO, Locey B, Emerson SG. Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells. Journal of Cellular Physiology. 147: 344-53. PMID 2040665 DOI: 10.1002/jcp.1041470221  0.64
1991 Keasling JD, Palsson BO, Cooper S. Cell-cycle-specific F plasmid replication: regulation by cell size control of initiation. Journal of Bacteriology. 173: 2673-80. PMID 2013579  0.96
1991 Schwartz RM, Palsson BO, Emerson SG. Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures. Proceedings of the National Academy of Sciences of the United States of America. 88: 6760-4. PMID 1862099 DOI: 10.1073/pnas.88.15.6760  1
1991 Schwartz RM, Emerson SG, Clarke MF, Palsson BO. In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors. Blood. 78: 3155-61. PMID 1742483  1
1991 Ozturk SS, Palsson BO. Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 2. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor. Biotechnology Progress. 7: 481-94. PMID 1367750 DOI: 10.1021/bp00012a002  1
1991 Ozturk SS, Palsson BO. Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 1. Analysis of data from controlled batch reactors. Biotechnology Progress. 7: 471-80. PMID 1367749 DOI: 10.1021/bp00012a001  1
1991 Ozturk SS, Palsson BO. Examination of serum and bovine serum albumin as shear protective agents in agitated cultures of hybridoma cells. Journal of Biotechnology. 18: 13-28. PMID 1367099 DOI: 10.1016/0168-1656(91)90232-K  1
1991 Lee GM, Varma A, Palsson BO. Application of population balance model to the loss of hybridoma antibody productivity. Biotechnology Progress. 7: 72-5. PMID 1366981 DOI: 10.1021/bp00007a013  1
1991 Caldwell J, Locey B, Clarke MF, Emerson SG, Palsson BO. Influence of medium exchange schedules on metabolic, growth, and GM-CSF secretion rates of genetically engineered NIH-3T3 cells. Biotechnology Progress. 7: 1-8. PMID 1366977 DOI: 10.1021/bp00007a001  0.64
1990 Lee GM, Palsson BO. Immobilization can improve the stability of hybridoma antibody productivity in serum-free media. Biotechnology and Bioengineering. 36: 1049-55. PMID 18595043 DOI: 10.1002/bit.260361010  1
1990 Palsson BO, Keasling JD, Emerson SG. The regulatory mechanisms of human immunodeficiency virus replication predict multiple expression rates. Proceedings of the National Academy of Sciences of the United States of America. 87: 772-6. PMID 2405389  0.96
1990 Ozturk SS, Dressman JB, Palsson BO. On the use of the quasi-equilibrium assumption for drug dissolution. Pharmaceutical Research. 7: 425-9. PMID 2362919 DOI: 10.1023/A:1015892011092  1
1990 Ozturk SS, Palsson BO. Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum-free media. Hybridoma. 9: 167-75. PMID 2347598  1
1990 Joshi A, Palsson BO. Metabolic dynamics in the human red cell. Part IV--Data prediction and some model computations. Journal of Theoretical Biology. 142: 69-85. PMID 2141094  1
1990 Joshi A, Palsson BO. Metabolic dynamics in the human red cell. Part III--Metabolic reaction rates. Journal of Theoretical Biology. 142: 41-68. PMID 2141093  1
1990 Lee ID, Palsson BO. A comprehensive model of human erythrocyte metabolism: extensions to include pH effects. Biomedica Biochimica Acta. 49: 771-89. PMID 2082921  1
1990 Ozturk SS, Palsson BO. Effect of initial cell density on hybridoma growth, metabolism, and monoclonal antibody production. Journal of Biotechnology. 16: 259-78. PMID 1366938 DOI: 10.1016/0168-1656(90)90041-9  1
1990 Ozturk SS, Palsson BO. Effects of dissolved oxygen on hybridoma cell growth, metabolism, and antibody production kinetics in continuous culture. Biotechnology Progress. 6: 437-46. PMID 1366834 DOI: 10.1021/bp00006a006  1
1990 Ozturk SS, Palsson BO. Chemical decomposition of glutamine in cell culture media: effect of media type, pH, and serum concentration. Biotechnology Progress. 6: 121-8. PMID 1366484 DOI: 10.1021/bp00002a005  1
1989 Ozturk SS, Palsson BO, Thiele JH. Control of interspecies electron transfer flow during anaerobic digestion: dynamic diffusion reaction models for hydrogen gas transfer in microbial flocs. Biotechnology and Bioengineering. 33: 745-57. PMID 18587976 DOI: 10.1002/bit.260330612  1
1989 Keasling JD, Palsson BO. On the kinetics of plasmid replication. Journal of Theoretical Biology. 136: 487-92. PMID 2811403  0.96
1989 Lee GM, Huard TK, Palsson BO. Effect of serum concentration on hybridoma cell growth and monoclonal antibody production at various initial cell densities. Hybridoma. 8: 369-75. PMID 2744789  1
1989 Palsson BO, Narang A, Joshi A. Computer model of human erythrocyte metabolism. Progress in Clinical and Biological Research. 319: 133-50; discussion 1. PMID 2695934  1
1989 Lee GM, Savinell JM, Palsson BO. Serum can act as a shear protecting agent in agitated hybridoma cell cultures. Hybridoma. 8: 639-45. PMID 2693339  1
1989 Joshi A, Palsson BO. Metabolic dynamics in the human red cell. Part II--Interactions with the environment. Journal of Theoretical Biology. 141: 529-45. PMID 2630804  1
1989 Joshi A, Palsson BO. Metabolic dynamics in the human red cell. Part I--A comprehensive kinetic model. Journal of Theoretical Biology. 141: 515-28. PMID 2630803  1
1989 Keasling JD, Palsson BO. ColE1 plasmid replication: a simple kinetic description from a structured model. Journal of Theoretical Biology. 141: 447-61. PMID 2483575  0.96
1988 Joshi A, Palsson BO. Escherichia coil growth dynamics: A three-pool biochemically based description. Biotechnology and Bioengineering. 31: 102-16. PMID 18581570 DOI: 10.1002/bit.260310203  1
1988 Ozturk SS, Palsson BO, Donohoe B, Dressman JB. Kinetics of release from enteric-coated tablets. Pharmaceutical Research. 5: 550-65. PMID 3247318 DOI: 10.1023/A:1015937912504  1
1988 Ozturk SS, Palsson BO, Dressman JB. Dissolution of ionizable drugs in buffered and unbuffered solutions. Pharmaceutical Research. 5: 272-82. PMID 3244637 DOI: 10.1023/A:1015970502993  1
1987 Palsson BO, Joshi A. On the dynamic order of structured Escherichia coli growth models. Biotechnology and Bioengineering. 29: 789-92. PMID 18576521 DOI: 10.1002/bit.260290623  1
1987 Palsson BO, Joshi A, Ozturk SS. Reducing complexity in metabolic networks: making metabolic meshes manageable. Federation Proceedings. 46: 2485-9. PMID 3297796  1
1985 Palsson BO, Lightfoot EN. Mathematical modelling of dynamics and control in metabolic networks. V. Static bifurcations in single biochemical control loops. Journal of Theoretical Biology. 113: 279-98. PMID 3999779 DOI: 10.1016/S0022-5193(85)80228-9  1
1985 Palsson BO, Lightfoot EN. Mathematical modelling of dynamics and control in metabolic networks. IV. Local stability analysis of single biochemical control loops. Journal of Theoretical Biology. 113: 261-77. PMID 3999778 DOI: 10.1016/S0022-5193(85)80227-7  1
1985 Palsson BO, Palsson H, Lightfoot EN. Mathematical modelling of dynamics and control in metabolic networks. III. Linear reaction sequences. Journal of Theoretical Biology. 113: 231-59. PMID 3999777 DOI: 10.1016/S0022-5193(85)80226-5  1
1984 Palsson BO, Jamier R, Lightfoot EN. Mathematical modelling of dynamics and control in metabolic networks. II. Simple dimeric enzymes. Journal of Theoretical Biology. 111: 303-21. PMID 6513573 DOI: 10.1016/S0022-5193(84)80212-X  1
1984 Palsson BO, Lightfoot EN. Mathematical modelling of dynamics and control in metabolic networks. I. On Michaelis-Menten kinetics. Journal of Theoretical Biology. 111: 273-302. PMID 6513572 DOI: 10.1016/S0022-5193(84)80211-8  1
1981 Palsson BO, Fathi-Afshar S, Rudd DF, Lightfoot EN. Biomass as a source of chemical feedstocks: an economic evaluation. Science (New York, N.Y.). 213: 513-7. PMID 17794821 DOI: 10.1126/science.213.4507.513  1
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