William J. Jusko - Publications

Affiliations: 
Pharmaceutical Sciences State University of New York, Buffalo, Buffalo, NY, United States 

179 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yu R, Song D, DuBois DC, Almon RR, Jusko WJ. Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats. The Aaps Journal. 21: 93. PMID 31342216 DOI: 10.1208/s12248-019-0362-6  0.64
2019 Ayyar VS, Song D, DuBois DC, Almon RR, Jusko WJ. Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics - I: Determination and Prediction of Dexamethasone and Methylprednisolone Tissue Binding in the Rat. The Journal of Pharmacology and Experimental Therapeutics. PMID 31197020 DOI: 10.1124/jpet.119.257519  0.64
2019 Ayyar VS, DuBois DC, Nakamura T, Almon RR, Jusko WJ. Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics - II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression. The Journal of Pharmacology and Experimental Therapeutics. PMID 31197019 DOI: 10.1124/jpet.119.257527  0.64
2019 Ayyar VS, DuBois DC, Almon RR, Jusko WJ. Modeling Corticosteroid Pharmacokinetics & Pharmacodynamics - III: Estrous Cycle- and Estrogen Receptor-Dependent Antagonism of GILZ Enhancement by Corticosteroids. The Journal of Pharmacology and Experimental Therapeutics. PMID 31197018 DOI: 10.1124/jpet.119.257543  0.64
2019 Barcellos T, Natavio M, Stanczyk FZ, Luo D, Jusko WJ, Bender NM. Effects of ritonavir-boosted protease inhibitors on combined oral contraceptive pharmacokinetics and pharmacodynamics in HIV-positive women. Contraception. PMID 31194965 DOI: 10.1016/j.contraception.2019.06.002  0.36
2019 Mavroudis PD, Ayyar VS, Jusko WJ. ATLAS mPBPK: a MATLAb-based tool for modeling and Simulation of minimal Physiologically Based PharmacoKinetic models. Cpt: Pharmacometrics & Systems Pharmacology. PMID 31154668 DOI: 10.1002/psp4.12441  0.36
2019 Acevedo A, Berthel A, DuBois D, Almon RR, Jusko WJ, Androulakis IP. Pathway-Based Analysis of the Liver Response to Intravenous Methylprednisolone Administration in Rats: Acute Versus Chronic Dosing. Gene Regulation and Systems Biology. 13: 1177625019840282. PMID 31019365 DOI: 10.1177/1177625019840282  0.64
2019 Mavroudis PD, van den Anker J, Conklin LS, Damsker JM, Hoffman EP, Nagaraju K, Clemens PR, Jusko WJ. Population Pharmacokinetics of Vamorolone (VBP15) in Healthy Men and Boys With Duchenne Muscular Dystrophy. Journal of Clinical Pharmacology. PMID 30742306 DOI: 10.1002/jcph.1388  0.44
2019 Natavio M, Stanczyk FZ, Molins EAG, Nelson A, Jusko WJ. Pharmacokinetics of the 1.5mg levonorgestrel emergency contraceptive in women with normal, obese and extremely obese body mass index. Contraception. PMID 30703352 DOI: 10.1016/j.contraception.2019.01.003  0.36
2019 Ayyar VS, Krzyzanski W, Jusko WJ. Indirect pharmacodynamic models for responses with circadian removal. Journal of Pharmacokinetics and Pharmacodynamics. 46: 89-101. PMID 30694437 DOI: 10.1007/s10928-019-09620-z  0.76
2019 Luo D, Carter KA, Molins EAG, Straubinger NL, Geng J, Shao S, Jusko WJ, Straubinger RM, Lovell JF. Pharmacokinetics and pharmacodynamics of liposomal chemophototherapy with short drug-light intervals. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30684512 DOI: 10.1016/j.jconrel.2019.01.030  1
2019 Luo D, Westhoff CL, Edelman AB, Natavio M, Stanczyk FZ, Jusko WJ. Altered pharmacokinetics of combined Oral contraceptives in obesity - multi-study assessment. Contraception. PMID 30684471 DOI: 10.1016/j.contraception.2018.12.009  0.36
2018 Conklin LS, Damsker JM, Hoffman EP, Jusko WJ, Mavroudis PD, Schwartz BD, Mengle-Gaw LJ, Smith EC, Mah JK, Guglieri M, Nevo Y, Kuntz N, McDonald CM, Tulinius M, Ryan MM, et al. Phase IIa trial in Duchenne muscular dystrophy shows vamorolone is a first-in-class dissociative steroidal anti-inflammatory drug. Pharmacological Research. PMID 30219580 DOI: 10.1016/j.phrs.2018.09.007  0.44
2018 Song D, DuBois DC, Almon RR, Jusko WJ. Modeling Sex Differences in Anti-inflammatory Effects of Dexamethasone in Arthritic Rats. Pharmaceutical Research. 35: 203. PMID 30191329 DOI: 10.1007/s11095-018-2483-5  0.64
2018 Ayyar VS, Sukumaran S, DuBois DC, Almon RR, Jusko WJ. Modeling Corticosteroid Pharmacogenomics and Proteomics in Rat Liver. The Journal of Pharmacology and Experimental Therapeutics. PMID 30087156 DOI: 10.1124/jpet.118.251959  0.64
2018 Zhu X, Shen X, Qu J, Straubinger RM, Jusko WJ. Multi-Scale Network Model Supported by Proteomics for Analysis of Combined Gemcitabine and Birinapant Effects in Pancreatic Cancer Cells. Cpt: Pharmacometrics & Systems Pharmacology. PMID 30084546 DOI: 10.1002/psp4.12320  1
2018 Zhu X, Trueman S, Straubinger RM, Jusko WJ. Physiologically-based pharmacokinetic and pharmacodynamic models for gemcitabine and birinapant in pancreatic cancer xenografts. Journal of Pharmacokinetics and Pharmacodynamics. PMID 30069744 DOI: 10.1007/s10928-018-9603-z  1
2018 Molins EAG, Jusko WJ. Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells. The Aaps Journal. 20: 80. PMID 29951754 DOI: 10.1208/s12248-018-0235-4  0.36
2018 Mavroudis PD, DuBois DC, Almon RR, Jusko WJ. Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat. Plos One. 13: e0197534. PMID 29894471 DOI: 10.1371/journal.pone.0197534  0.64
2018 Mavroudis PD, DuBois DC, Almon RR, Jusko WJ. Daily variation of gene expression in diverse rat tissues. Plos One. 13: e0197258. PMID 29746605 DOI: 10.1371/journal.pone.0197258  0.64
2018 Ayyar VS, Sukumaran S, DuBois DC, Almon RR, Qu J, Jusko WJ. Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver. Journal of Pharmacokinetics and Pharmacodynamics. PMID 29704219 DOI: 10.1007/s10928-018-9585-x  1
2018 Zhu X, Shen X, Qu J, Straubinger RM, Jusko WJ. Proteomic Analysis of Combined Gemcitabine and Birinapant in Pancreatic Cancer Cells. Frontiers in Pharmacology. 9: 84. PMID 29520231 DOI: 10.3389/fphar.2018.00084  1
2017 McLaughlin MJ, He Y, Brunstrom-Hernandez J, Thio LL, Carleton BC, Ross CJD, Gaedigk A, Lewandowski A, Dai H, Jusko WJ, Leeder JS. Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children with Cerebral Palsy. Pm & R : the Journal of Injury, Function, and Rehabilitation. PMID 28867665 DOI: 10.1016/j.pmrj.2017.08.441  0.48
2017 Ayyar VS, DuBois DC, Almon RR, Jusko WJ. Mechanistic Multi-Tissue Modeling of GILZ Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics. The Journal of Pharmacology and Experimental Therapeutics. PMID 28729456 DOI: 10.1124/jpet.117.242990  0.64
2017 Nie J, DuBois DC, Xue B, Jusko WJ, Almon RR. Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats. Gene Regulation and Systems Biology. 11: 1177625017710009. PMID 28607540 DOI: 10.1177/1177625017710009  0.64
2017 Li X, DuBois DC, Song D, Almon RR, Jusko WJ, Chen X. Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28416614 DOI: 10.1124/dmd.117.075614  0.64
2017 Chen X, DuBois DC, Almon RR, Jusko WJ. Interrelationships between Infliximab and rhTNF-α in Plasma using Minimal Physiologically-Based Pharmacokinetic (mPBPK) Models. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28411280 DOI: 10.1124/dmd.116.074807  0.64
2017 Chen X, DuBois DC, Almon RR, Jusko WJ. Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically-Based Pharmacokinetic (mPBPK) Models. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28411279 DOI: 10.1124/dmd.116.074799  0.64
2017 Ayyar VS, Almon RR, DuBois DC, Sukumaran S, Qu J, Jusko WJ. Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism. Journal of Proteomics. PMID 28315483 DOI: 10.1016/j.jprot.2017.03.007  1
2017 Kamisoglu K, Acevedo A, Almon RR, Coyle S, Corbett S, Dubois DC, Nguyen TT, Jusko WJ, Androulakis IP. Understanding Physiology in the Continuum: Integration of Information from Multiple -Omics Levels. Frontiers in Pharmacology. 8: 91. PMID 28289389 DOI: 10.3389/fphar.2017.00091  0.64
2017 Li X, DuBois DC, Almon RR, Jusko WJ. Modeling Sex Differences in Pharmacokinetics, Pharmacodynamics, and Disease Progression Effects of Naproxen in Rats with Collagen-Induced Arthritis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28246127 DOI: 10.1124/dmd.116.074526  0.64
2017 Li X, DuBois DC, Almon RR, Jusko WJ. Effect of Disease-Related Changes in Plasma Albumin on the Pharmacokinetics of Naproxen in Male and Female Arthritic Rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 28246126 DOI: 10.1124/dmd.116.074500  0.64
2017 Koch G, Jusko WJ, Schropp J. Target mediated drug disposition with drug-drug interaction, Part II: competitive and uncompetitive cases. Journal of Pharmacokinetics and Pharmacodynamics. PMID 28074396 DOI: 10.1007/s10928-016-9502-0  0.44
2017 Koch G, Jusko WJ, Schropp J. Target-mediated drug disposition with drug-drug interaction, Part I: single drug case in alternative formulations. Journal of Pharmacokinetics and Pharmacodynamics. PMID 28074395 DOI: 10.1007/s10928-016-9501-1  0.44
2016 Miao X, Koch G, Ait-Oudhia S, Straubinger RM, Jusko WJ. Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells. Frontiers in Pharmacology. 7: 421. PMID 27895579 DOI: 10.3389/fphar.2016.00421  1
2016 Koch G, Schropp J, Jusko WJ. Assessment of non-linear combination effect terms for drug-drug interactions. Journal of Pharmacokinetics and Pharmacodynamics. PMID 27638639 DOI: 10.1007/s10928-016-9490-0  0.44
2016 Rao RT, DuBois DC, Almon RR, Jusko WJ, Androulakis IP. Mathematical Modeling of the Circadian Dynamics of the Neuroendocrine-Immune Network in Experimentally Induced Arthritis. American Journal of Physiology. Endocrinology and Metabolism. ajpendo.00006.2016. PMID 27221115 DOI: 10.1152/ajpendo.00006.2016  0.64
2015 Miao X, Koch G, Straubinger RM, Jusko WJ. Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells. Cancer Chemotherapy and Pharmacology. PMID 26604207 DOI: 10.1007/s00280-015-2907-4  1
2015 Lon HK, DuBois DC, Earp JC, Almon RR, Jusko WJ. Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats. Pharmacology Research & Perspectives. 3: e00169. PMID 26516581 DOI: 10.1002/prp2.169  0.72
2015 Xue B, Nie J, Wang X, DuBois DC, Jusko WJ, Almon RR. Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats. Gene Regulation and Systems Biology. 9: 15-26. PMID 26309393 DOI: 10.4137/GRSB.S25172  0.64
2015 Zhu X, Straubinger RM, Jusko WJ. Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cells. Journal of Pharmacokinetics and Pharmacodynamics. 42: 477-96. PMID 26252969 DOI: 10.1007/s10928-015-9429-x  1
2015 Ayyar VS, Almon RR, Jusko WJ, DuBois DC. Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids. Physiological Reports. 3. PMID 26056061 DOI: 10.14814/phy2.12382  0.64
2015 Chen X, DuBois DC, Almon RR, Jusko WJ. Biodistribution of etanercept to tissues and sites of inflammation in arthritic rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 898-907. PMID 25834031 DOI: 10.1124/dmd.114.062901  0.64
2015 Kamisoglu K, Sukumaran S, Nouri-Nigjeh E, Tu C, Li J, Shen X, Duan X, Qu J, Almon RR, DuBois DC, Jusko WJ, Androulakis IP. Tandem analysis of transcriptome and proteome changes after a single dose of corticosteroid: a systems approach to liver function in pharmacogenomics. Omics : a Journal of Integrative Biology. 19: 80-91. PMID 25611119 DOI: 10.1089/omi.2014.0130  1
2015 Grimsrud KN, Ait-Oudhia S, Durbin-Johnson BP, Rocke DM, Mama KR, Rezende ML, Stanley SD, Jusko WJ. Pharmacokinetic and pharmacodynamic analysis comparing diverse effects of detomidine, medetomidine, and dexmedetomidine in the horse: a population analysis. Journal of Veterinary Pharmacology and Therapeutics. 38: 24-34. PMID 25073816 DOI: 10.1111/jvp.12139  1
2014 Wang X, DuBois DC, Sukumaran S, Ayyar V, Jusko WJ, Almon RR. Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 7: 531-41. PMID 25419150 DOI: 10.2147/DMSO.S69891  1
2014 Wang X, DuBois DC, Cao Y, Jusko WJ, Almon RR. Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 7: 381-9. PMID 25120374 DOI: 10.2147/DMSO.S65818  1
2014 Nouri-Nigjeh E, Sukumaran S, Tu C, Li J, Shen X, Duan X, DuBois DC, Almon RR, Jusko WJ, Qu J. Highly multiplexed and reproducible ion-current-based strategy for large-scale quantitative proteomics and the application to protein expression dynamics induced by methylprednisolone in 60 rats. Analytical Chemistry. 86: 8149-57. PMID 25072516 DOI: 10.1021/ac501380s  1
2014 Nguyen TT, Almon RR, Dubois DC, Sukumaran S, Jusko WJ, Androulakis IP. Tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration. Gene Regulation and Systems Biology. 8: 75-87. PMID 24653645 DOI: 10.4137/GRSB.S13134  1
2014 He Y, Brunstrom-Hernandez JE, Thio LL, Lackey S, Gaebler-Spira D, Kuroda MM, Stashinko E, Hoon AH, Vargus-Adams J, Stevenson RD, Lowenhaupt S, McLaughlin JF, Christensen A, Dosa NP, Butler M, ... ... Jusko WJ, et al. Population pharmacokinetics of oral baclofen in pediatric patients with cerebral palsy. The Journal of Pediatrics. 164: 1181-1188.e8. PMID 24607242 DOI: 10.1016/j.jpeds.2014.01.029  1
2013 Fang J, Sukumaran S, Dubois DC, Almon RR, Jusko WJ. Meta-modeling of methylprednisolone effects on glucose regulation in rats. Plos One. 8: e81679. PMID 24312573 DOI: 10.1371/journal.pone.0081679  1
2013 Lon HK, Liu D, DuBois DC, Almon RR, Jusko WJ. Modeling pharmacokinetics/pharmacodynamics of abatacept and disease progression in collagen-induced arthritic rats: a population approach. Journal of Pharmacokinetics and Pharmacodynamics. 40: 701-12. PMID 24233383 DOI: 10.1007/s10928-013-9341-1  1
2013 Hamed SS, Straubinger RM, Jusko WJ. Pharmacodynamic modeling of cell cycle and apoptotic effects of gemcitabine on pancreatic adenocarcinoma cells. Cancer Chemotherapy and Pharmacology. 72: 553-63. PMID 23835677 DOI: 10.1007/s00280-013-2226-6  1
2013 Liu DY, Lon HK, Wang YL, DuBois DC, Almon RR, Jusko WJ. Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen-induced arthritic rats. Biopharmaceutics & Drug Disposition. 34: 203-14. PMID 23456770 DOI: 10.1002/bdd.1838  1
2013 Pawaskar DK, Straubinger RM, Fetterly GJ, Hylander BH, Repasky EA, Ma WW, Jusko WJ. Synergistic interactions between sorafenib and everolimus in pancreatic cancer xenografts in mice. Cancer Chemotherapy and Pharmacology. 71: 1231-40. PMID 23455452 DOI: 10.1007/s00280-013-2117-x  1
2013 Pawaskar DK, Straubinger RM, Fetterly GJ, Hylander BH, Repasky EA, Ma WW, Jusko WJ. Physiologically based pharmacokinetic models for everolimus and sorafenib in mice. Cancer Chemotherapy and Pharmacology. 71: 1219-29. PMID 23455451 DOI: 10.1007/s00280-013-2116-y  1
2013 DuBois DC, Sukumaran S, Jusko WJ, Almon RR. Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver. Steroids. 78: 312-20. PMID 23257260 DOI: 10.1016/j.steroids.2012.11.014  1
2013 Pawaskar DK, Straubinger RM, Fetterly GJ, Ma WW, Jusko WJ. Interactions of everolimus and sorafenib in whole blood lymphocyte proliferation. Pharmaceutical Research. 30: 707-13. PMID 23151723 DOI: 10.1007/s11095-012-0909-z  1
2013 Pawaskar DK, Straubinger RM, Fetterly GJ, Ma WW, Jusko WJ. Interactions of everolimus and sorafenib in pancreatic cancer cells. The Aaps Journal. 15: 78-84. PMID 23054975 DOI: 10.1208/s12248-012-9417-7  1
2013 Fang J, Landersdorfer CB, Cirincione B, Jusko WJ. Study reanalysis using a mechanism-based pharmacokinetic/pharmacodynamic model of pramlintide in subjects with type 1 diabetes. The Aaps Journal. 15: 15-29. PMID 23054970 DOI: 10.1208/s12248-012-9409-7  0.6
2012 Almon RR, Dubois DC, Sukumaran S, Wang X, Xue B, Nie J, Jusko WJ. Effects of high fat feeding on liver gene expression in diabetic goto-kakizaki rats. Gene Regulation and Systems Biology. 6: 151-68. PMID 23236253 DOI: 10.4137/GRSB.S10371  1
2012 Lon HK, Liu D, Jusko WJ. Pharmacokinetic/pharmacodynamic modeling in inflammation. Critical Reviews in Biomedical Engineering. 40: 295-312. PMID 23140121 DOI: 10.1615/CritRevBiomedEng.v40.i4.50  1
2012 Sukumaran S, Dubois DC, Jusko WJ, Almon RR. Glucocorticoid effects on adiponectin expression. Vitamins and Hormones. 90: 163-86. PMID 23017716 DOI: 10.1016/B978-0-12-398313-8.00007-5  1
2012 Cao Y, DuBois DC, Almon RR, Jusko WJ. Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats. Biopharmaceutics & Drug Disposition. 33: 285-91. PMID 22782506 DOI: 10.1002/bdd.1797  1
2012 Landersdorfer CB, He YL, Jusko WJ. Mechanism-based population pharmacokinetic modelling in diabetes: vildagliptin as a tight binding inhibitor and substrate of dipeptidyl peptidase IV. British Journal of Clinical Pharmacology. 73: 391-401. PMID 22442826  0.6
2012 Landersdorfer CB, He YL, Jusko WJ. Mechanism-based population modelling of the effects of vildagliptin on GLP-1, glucose and insulin in patients with type 2 diabetes. British Journal of Clinical Pharmacology. 73: 373-90. PMID 22442825  0.6
2012 Sukumaran S, Lepist EI, DuBois DC, Almon RR, Jusko WJ. Pharmacokinetic/pharmacodynamic modeling of methylprednisolone effects on iNOS mRNA expression and nitric oxide during LPS-induced inflammation in rats. Pharmaceutical Research. 29: 2060-9. PMID 22422321 DOI: 10.1007/s11095-012-0733-5  1
2011 Liu D, Lon HK, Dubois DC, Almon RR, Jusko WJ. Population pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis. Journal of Pharmacokinetics and Pharmacodynamics. 38: 769-86. PMID 22002845 DOI: 10.1007/s10928-011-9219-z  1
2011 Cao Y, Dubois DC, Sun H, Almon RR, Jusko WJ. Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats. The Journal of Pharmacology and Experimental Therapeutics. 339: 896-904. PMID 21903749 DOI: 10.1124/jpet.111.185686  1
2011 Bai JP, Bell R, Buckman S, Burckart GJ, Eichler HG, Fang KC, Goodsaid FM, Jusko WJ, Lesko LL, Meibohm B, Patterson SD, Puig O, Smerage JB, Snider BJ, Wagner JA, et al. Translational biomarkers: from preclinical to clinical a report of 2009 AAPS/ACCP Biomarker Workshop. The Aaps Journal. 13: 274-83. PMID 21448748 DOI: 10.1208/s12248-011-9265-x  1
2011 Sukumaran S, Jusko WJ, Dubois DC, Almon RR. Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action. Journal of Applied Physiology (Bethesda, Md. : 1985). 110: 1732-47. PMID 21436464 DOI: 10.1152/japplphysiol.00079.2011  1
2011 Sukumaran S, Jusko WJ, DuBois DC, Almon RR. Mechanistic modeling of the effects of glucocorticoids and circadian rhythms on adipokine expression. The Journal of Pharmacology and Experimental Therapeutics. 337: 734-46. PMID 21398515 DOI: 10.1124/jpet.111.179960  1
2011 Fang J, DuBois DC, He Y, Almon RR, Jusko WJ. Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats. Journal of Pharmacokinetics and Pharmacodynamics. 38: 293-316. PMID 21394487 DOI: 10.1007/s10928-011-9194-4  1
2011 Xue B, Sukumaran S, Nie J, Jusko WJ, Dubois DC, Almon RR. Adipose tissue deficiency and chronic inflammation in diabetic Goto-Kakizaki rats. Plos One. 6: e17386. PMID 21364767 DOI: 10.1371/journal.pone.0017386  1
2011 Lon HK, Liu D, Zhang Q, DuBois DC, Almon RR, Jusko WJ. Pharmacokinetic-pharmacodynamic disease progression model for effect of etanercept in Lewis rats with collagen-induced arthritis. Pharmaceutical Research. 28: 1622-30. PMID 21360252 DOI: 10.1007/s11095-011-0396-7  1
2011 Nie J, Xue B, Sukumaran S, Jusko WJ, Dubois DC, Almon RR. Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats. Molecular and Cellular Endocrinology. 338: 10-7. PMID 21356272 DOI: 10.1016/j.mce.2011.02.016  1
2011 Scheff JD, Almon RR, Dubois DC, Jusko WJ, Androulakis IP. Assessment of pharmacologic area under the curve when baselines are variable. Pharmaceutical Research. 28: 1081-9. PMID 21234658 DOI: 10.1007/s11095-010-0363-8  1
2011 Nie J, DuBois DC, Jusko WJ, Almon RR. Mechanistic population modeling of diabetes disease progression in Goto-Kakizaki rat muscle. Biopharmaceutics & Drug Disposition. 32: 50-63. PMID 21162119 DOI: 10.1002/bdd.738  1
2011 Gao W, Bihorel S, DuBois DC, Almon RR, Jusko WJ. Mechanism-based disease progression modeling of type 2 diabetes in Goto-Kakizaki rats. Journal of Pharmacokinetics and Pharmacodynamics. 38: 143-62. PMID 21127951 DOI: 10.1007/s10928-010-9182-0  1
2010 Ovacik MA, Sukumaran S, Almon RR, DuBois DC, Jusko WJ, Androulakis IP. Circadian signatures in rat liver: from gene expression to pathways. Bmc Bioinformatics. 11: 540. PMID 21040584 DOI: 10.1186/1471-2105-11-540  1
2010 Nguyen TT, Almon RR, Dubois DC, Jusko WJ, Androulakis IP. Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: transcriptional dynamics and regulatory structures. Bmc Bioinformatics. 11: 515. PMID 20946642 DOI: 10.1186/1471-2105-11-515  1
2010 Landersdorfer CB, Jusko WJ. Pharmacokinetic/pharmacodynamic modeling of glucose clamp effects of inhaled and subcutaneous insulin in healthy volunteers and diabetic patients. Drug Metabolism and Pharmacokinetics. 25: 418-29. PMID 20924141 DOI: JST.JSTAGE/dmpk/DMPK-10-RG-017  0.6
2010 Sukumaran S, Xue B, Jusko WJ, Dubois DC, Almon RR. Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology. Physiological Genomics. 42: 141-52. PMID 20682845 DOI: 10.1152/physiolgenomics.00106.2010  1
2010 Sukumaran S, Almon RR, DuBois DC, Jusko WJ. Circadian rhythms in gene expression: Relationship to physiology, disease, drug disposition and drug action. Advanced Drug Delivery Reviews. 62: 904-17. PMID 20542067 DOI: 10.1016/j.addr.2010.05.009  1
2010 Findling RL, Landersdorfer CB, Kafantaris V, Pavuluri M, McNamara NK, McClellan J, Frazier JA, Sikich L, Kowatch R, Lingler J, Faber J, Taylor-Zapata P, Jusko WJ. First-dose pharmacokinetics of lithium carbonate in children and adolescents. Journal of Clinical Psychopharmacology. 30: 404-10. PMID 20531219 DOI: 10.1097/JCP.0b013e3181e66a62  1
2010 Nguyen TT, Almon RR, DuBois DC, Jusko WJ, Androulakis IP. Importance of replication in analyzing time-series gene expression data: corticosteroid dynamics and circadian patterns in rat liver. Bmc Bioinformatics. 11: 279. PMID 20500897 DOI: 10.1186/1471-2105-11-279  1
2010 Scheff JD, Almon RR, DuBois DC, Jusko WJ, Androulakis IP. A new symbolic representation for the identification of informative genes in replicated microarray experiments. Omics : a Journal of Integrative Biology. 14: 239-48. PMID 20455749 DOI: 10.1089/omi.2010.0005  1
2010 Bulitta JB, Yang JC, Yohonn L, Ly NS, Brown SV, D'Hondt RE, Jusko WJ, Forrest A, Tsuji BT. Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model. Antimicrobial Agents and Chemotherapy. 54: 2051-62. PMID 20211900 DOI: 10.1128/AAC.00881-09  1
2010 Hale G, Rebello P, Al Bakir I, Bolam E, Wiczling P, Jusko WJ, Vandemeulebroucke E, Keymeulen B, Mathieu C, Ziegler AG, Chatenoud L, Waldmann H. Pharmacokinetics and antibody responses to the CD3 antibody otelixizumab used in the treatment of type 1 diabetes. Journal of Clinical Pharmacology. 50: 1238-48. PMID 20147616 DOI: 10.1177/0091270009356299  1
2010 Ghoshal S, Rao I, Earp JC, Jusko WJ, Wetzler M. Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity. Cancer Chemotherapy and Pharmacology. 66: 681-9. PMID 20035426 DOI: 10.1007/s00280-009-1210-7  1
2010 Wiczling P, Rosenzweig M, Vaickus L, Jusko WJ. Pharmacokinetics and pharmacodynamics of a chimeric/humanized anti-CD3 monoclonal antibody, otelixizumab (TRX4), in subjects with psoriasis and with type 1 diabetes mellitus. Journal of Clinical Pharmacology. 50: 494-506. PMID 19934031 DOI: 10.1177/0091270009349376  1
2009 Khinkis LA, Krzyzanski W, Jusko WJ, Greco WR. D-optimal designs for parameter estimation for indirect pharmacodynamic response models. Journal of Pharmacokinetics and Pharmacodynamics. 36: 523-39. PMID 19904585 DOI: 10.1007/s10928-009-9135-7  0.76
2009 Woo S, Pawaskar D, Jusko WJ. Methods of utilizing baseline values for indirect response models. Journal of Pharmacokinetics and Pharmacodynamics. 36: 381-405. PMID 19697107 DOI: 10.1007/s10928-009-9128-6  1
2009 Cho HY, Blum RA, Sunderland T, Cooper GJ, Jusko WJ. Pharmacokinetic and pharmacodynamic modeling of a copper-selective chelator (TETA) in healthy adults. Journal of Clinical Pharmacology. 49: 916-28. PMID 19602718 DOI: 10.1177/0091270009337939  1
2009 Yang EH, Almon RR, Dubois DC, Jusko WJ, Androulakis IP. Identification of global transcriptional dynamics. Plos One. 4: e5992. PMID 19593450 DOI: 10.1371/journal.pone.0005992  1
2009 Mager DE, Woo S, Jusko WJ. Scaling pharmacodynamics from in vitro and preclinical animal studies to humans. Drug Metabolism and Pharmacokinetics. 24: 16-24. PMID 19252333 DOI: JST.JSTAGE/dmpk/24.16  1
2009 Jin JY, Jusko WJ. Pharmacodynamics of glucose regulation by methylprednisolone. I. Adrenalectomized rats. Biopharmaceutics & Drug Disposition. 30: 21-34. PMID 19156931 DOI: 10.1002/bdd.643  1
2009 Jin JY, Jusko WJ. Pharmacodynamics of glucose regulation by methylprednisolone. II. normal rats. Biopharmaceutics & Drug Disposition. 30: 35-48. PMID 19156669 DOI: 10.1002/bdd.642  1
2009 Almon RR, DuBois DC, Lai W, Xue B, Nie J, Jusko WJ. Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats. The Journal of Endocrinology. 200: 331-46. PMID 19074471 DOI: 10.1677/JOE-08-0404  1
2009 Landersdorfer CB, DuBois DC, Almon RR, Jusko WJ. Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats. The Journal of Pharmacology and Experimental Therapeutics. 328: 644-51. PMID 18971370 DOI: 10.1124/jpet.108.144766  1
2009 Bulitta JB, Ly NS, Yang JC, Forrest A, Jusko WJ, Tsuji BT. Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. 53: 46-56. PMID 18852268 DOI: 10.1128/AAC.00489-08  1
2009 Bulitta JB, Zhao P, Arnold RD, Kessler DR, Daifuku R, Pratt J, Luciano G, Hanauske AR, Gelderblom H, Awada A, Jusko WJ. Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients. Cancer Chemotherapy and Pharmacology. 63: 1049-63. PMID 18791718 DOI: 10.1007/s00280-008-0827-2  0.32
2009 Bulitta JB, Zhao P, Arnold RD, Kessler DR, Daifuku R, Pratt J, Luciano G, Hanauske AR, Gelderblom H, Awada A, Jusko WJ. Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients. Cancer Chemotherapy and Pharmacology. 63: 1035-48. PMID 18791717 DOI: 10.1007/s00280-008-0828-1  0.32
2009 Earp JC, Dubois DC, Almon RR, Jusko WJ. Quantitative dynamic models of arthritis progression in the rat. Pharmaceutical Research. 26: 196-203. PMID 18758921 DOI: 10.1007/s11095-008-9711-3  1
2008 Yao Z, Hoffman EP, Ghimbovschi S, DuBois DC, Almon RR, Jusko WJ. Pharmacodynamic/pharmacogenomic modeling of insulin resistance genes in rat muscle after methylprednisolone treatment: exploring regulatory signaling cascades. Gene Regulation and Systems Biology. 2: 141-61. PMID 19787081  0.64
2008 Hazra A, DuBois DC, Almon RR, Snyder GH, Jusko WJ. Pharmacodynamic modeling of acute and chronic effects of methylprednisolone on hepatic urea cycle genes in rats. Gene Regulation and Systems Biology. 2: 1-19. PMID 19787073  0.64
2008 Almon RR, Yang E, Lai W, Androulakis IP, Ghimbovschi S, Hoffman EP, Jusko WJ, Dubois DC. Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R1031-47. PMID 18667713 DOI: 10.1152/ajpregu.90399.2008  1
2008 Earp JC, Pyszczynski NA, Molano DS, Jusko WJ. Pharmacokinetics of dexamethasone in a rat model of rheumatoid arthritis. Biopharmaceutics & Drug Disposition. 29: 366-72. PMID 18613033 DOI: 10.1002/bdd.626  1
2008 Landersdorfer CB, Jusko WJ. Pharmacokinetic/pharmacodynamic modelling in diabetes mellitus. Clinical Pharmacokinetics. 47: 417-48. PMID 18563953 DOI: 10.2165/00003088-200847070-00001  0.6
2008 Almon RR, Yang E, Lai W, Androulakis IP, DuBois DC, Jusko WJ. Circadian variations in rat liver gene expression: relationships to drug actions. The Journal of Pharmacology and Experimental Therapeutics. 326: 700-16. PMID 18562560 DOI: 10.1124/jpet.108.140186  1
2008 Earp JC, Dubois DC, Molano DS, Pyszczynski NA, Keller CE, Almon RR, Jusko WJ. Modeling corticosteroid effects in a rat model of rheumatoid arthritis I: mechanistic disease progression model for the time course of collagen-induced arthritis in Lewis rats. The Journal of Pharmacology and Experimental Therapeutics. 326: 532-45. PMID 18448865 DOI: 10.1124/jpet.108.137372  1
2008 Earp JC, Dubois DC, Molano DS, Pyszczynski NA, Almon RR, Jusko WJ. Modeling corticosteroid effects in a rat model of rheumatoid arthritis II: mechanistic pharmacodynamic model for dexamethasone effects in Lewis rats with collagen-induced arthritis. The Journal of Pharmacology and Experimental Therapeutics. 326: 546-54. PMID 18448864 DOI: 10.1124/jpet.108.137414  1
2008 Mager DE, Jusko WJ. Development of translational pharmacokinetic-pharmacodynamic models. Clinical Pharmacology and Therapeutics. 83: 909-12. PMID 18388873 DOI: 10.1038/clpt.2008.52  1
2008 Yao Z, Hoffman EP, Ghimbovschi S, Dubois DC, Almon RR, Jusko WJ. Mathematical modeling of corticosteroid pharmacogenomics in rat muscle following acute and chronic methylprednisolone dosing. Molecular Pharmaceutics. 5: 328-39. PMID 18271548 DOI: 10.1021/mp700094s  1
2008 Yang E, Almon RR, Dubois DC, Jusko WJ, Androulakis IP. Extracting global system dynamics of corticosteroid genomic effects in rat liver. The Journal of Pharmacology and Experimental Therapeutics. 324: 1243-54. PMID 18086872 DOI: 10.1124/jpet.107.133074  1
2008 Woo S, Krzyzanski W, Duliege AM, Stead RB, Jusko WJ. Population pharmacokinetics and pharmacodynamics of peptidic erythropoiesis receptor agonist (ERA) in healthy volunteers. Journal of Clinical Pharmacology. 48: 43-52. PMID 18025524 DOI: 10.1177/0091270007309702  1
2008 Woo S, Krzyzanski W, Jusko WJ. Pharmacodynamic model for chemotherapy-induced anemia in rats. Cancer Chemotherapy and Pharmacology. 62: 123-33. PMID 17891399 DOI: 10.1007/s00280-007-0582-9  1
2008 Yao Z, DuBois DC, Almon RR, Jusko WJ. Pharmacokinetic/pharmacodynamic modeling of corticosterone suppression and lymphocytopenia by methylprednisolone in rats. Journal of Pharmaceutical Sciences. 97: 2820-32. PMID 17828751 DOI: 10.1002/jps.21167  1
2008 Hazra A, Pyszczynski NA, DuBois DC, Almon RR, Jusko WJ. Modeling of corticosteroid effects on hepatic low-density lipoprotein receptors and plasma lipid dynamics in rats. Pharmaceutical Research. 25: 769-80. PMID 17674160 DOI: 10.1007/s11095-007-9371-8  1
2007 Woo S, Krzyzanski W, Jusko WJ. Target-mediated pharmacokinetic and pharmacodynamic model of recombinant human erythropoietin (rHuEPO). Journal of Pharmacokinetics and Pharmacodynamics. 34: 849-68. PMID 17943422 DOI: 10.1007/s10928-007-9074-0  1
2007 Hazra A, Pyszczynski N, DuBois DC, Almon RR, Jusko WJ. Modeling receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase dynamics in rats: dual regulation by endogenous and exogenous corticosteroids. Journal of Pharmacokinetics and Pharmacodynamics. 34: 643-67. PMID 17593325 DOI: 10.1007/s10928-007-9063-3  1
2007 Woo S, Jusko WJ. Interspecies comparisons of pharmacokinetics and pharmacodynamics of recombinant human erythropoietin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1672-8. PMID 17576810 DOI: 10.1124/dmd.107.015248  1
2007 Hazra A, Pyszczynski N, DuBois DC, Almon RR, Jusko WJ. Pharmacokinetics of methylprednisolone after intravenous and intramuscular administration in rats. Biopharmaceutics & Drug Disposition. 28: 263-73. PMID 17569107 DOI: 10.1002/bdd.551  1
2007 Almon RR, DuBois DC, Yao Z, Hoffman EP, Ghimbovschi S, Jusko WJ. Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens. Physiological Genomics. 30: 282-99. PMID 17473217 DOI: 10.1152/physiolgenomics.00242.2006  1
2007 Wetzler M, Earp JC, Brady MT, Keng MK, Jusko WJ. Synergism between arsenic trioxide and heat shock protein 90 inhibitors on signal transducer and activator of transcription protein 3 activity--pharmacodynamic drug-drug interaction modeling. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2261-70. PMID 17404111 DOI: 10.1158/1078-0432.CCR-06-2468  1
2007 Samtani MN, Jusko WJ. Quantification of dexamethasone and corticosterone in rat biofluids and fetal tissue using highly sensitive analytical methods: assay validation and application to a pharmacokinetic study. Biomedical Chromatography : Bmc. 21: 585-97. PMID 17385808 DOI: 10.1002/bmc.788  1
2007 Hong Y, Mager DE, Blum RA, Jusko WJ. Population pharmacokinetic/pharmacodynamic modeling of systemic corticosteroid inhibition of whole blood lymphocytes: modeling interoccasion pharmacodynamic variability. Pharmaceutical Research. 24: 1088-97. PMID 17385022 DOI: 10.1007/s11095-006-9232-x  1
2007 Yang E, Simcha D, Almon RR, Dubois DC, Jusko WJ, Androulakis IP. Context specific transcription factor prediction. Annals of Biomedical Engineering. 35: 1053-67. PMID 17377845 DOI: 10.1007/s10439-007-9268-z  1
2007 Yao Z, Zhao B, Hoffman EP, Ghimbovschi S, DuBois DC, Almon RR, Jusko WJ. Application of scaling factors in simultaneous modeling of microarray data from diverse chips. Pharmaceutical Research. 24: 643-9. PMID 17318415 DOI: 10.1007/s11095-006-9215-y  1
2007 Almon RR, DuBois DC, Jusko WJ. A microarray analysis of the temporal response of liver to methylprednisolone: a comparative analysis of two dosing regimens. Endocrinology. 148: 2209-25. PMID 17303664 DOI: 10.1210/en.2006-0790  1
2007 Hazra A, DuBois DC, Almon RR, Jusko WJ. Assessing the dynamics of nuclear glucocorticoid-receptor complex: adding flexibility to gene expression modeling. Journal of Pharmacokinetics and Pharmacodynamics. 34: 333-54. PMID 17285360 DOI: 10.1007/s10928-007-9049-1  1
2006 Hazra A, Krzyzanski W, Jusko WJ. Mathematical assessment of properties of precursor-dependent indirect pharmacodynamic response models. Journal of Pharmacokinetics and Pharmacodynamics. 33: 683-717. PMID 17053985 DOI: 10.1007/s10928-006-9030-4  1
2006 Woo S, Krzyzanski W, Jusko WJ. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 319: 1297-306. PMID 16973883 DOI: 10.1124/jpet.106.111377  1
2006 Schwab M, Coksaygan T, Samtani MN, Jusko WJ, Nathanielsz PW. Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses. Obstetrics and Gynecology. 108: 617-25. PMID 16946223 DOI: 10.1097/01.AOG.0000232815.80648.01  1
2006 Krzyzanski W, Dmochowski J, Matsushima N, Jusko WJ. Assessment of dosing impact on intra-individual variability in estimation of parameters for basic indirect response models. Journal of Pharmacokinetics and Pharmacodynamics. 33: 635-55. PMID 16941234 DOI: 10.1007/s10928-006-9028-y  1
2006 Qu J, Jusko WJ, Straubinger RM. Utility of cleavable isotope-coded affinity-tagged reagents for quantification of low-copy proteins induced by methylprednisolone using liquid chromatography/tandem mass spectrometry. Analytical Chemistry. 78: 4543-52. PMID 16808464 DOI: 10.1021/ac0521697  1
2006 Yao Z, DuBois DC, Almon RR, Jusko WJ. Modeling circadian rhythms of glucocorticoid receptor and glutamine synthetase expression in rat skeletal muscle. Pharmaceutical Research. 23: 670-9. PMID 16673181 DOI: 10.1007/s11095-005-9608-3  1
2006 Krzyzanski W, Woo S, Jusko WJ. Pharmacodynamic models for agents that alter production of natural cells with various distributions of lifespans. Journal of Pharmacokinetics and Pharmacodynamics. 33: 125-66. PMID 16565883 DOI: 10.1007/s10928-006-9007-3  1
2006 Yao Z, Krzyzanski W, Jusko WJ. Assessment of basic indirect pharmacodynamic response models with physiological limits. Journal of Pharmacokinetics and Pharmacodynamics. 33: 167-93. PMID 16547797 DOI: 10.1007/s10928-006-9003-7  0.76
2006 Samtani MN, Pyszczynski NA, Dubois DC, Almon RR, Jusko WJ. Modeling glucocorticoid-mediated fetal lung maturation: I. Temporal patterns of corticosteroids in rat pregnancy. The Journal of Pharmacology and Experimental Therapeutics. 317: 117-26. PMID 16371449 DOI: 10.1124/jpet.105.095851  1
2006 Samtani MN, Pyszczynski NA, Dubois DC, Almon RR, Jusko WJ. Modeling glucocorticoid-mediated fetal lung maturation: II. Temporal patterns of gene expression in fetal rat lung. The Journal of Pharmacology and Experimental Therapeutics. 317: 127-38. PMID 16371448 DOI: 10.1124/jpet.105.095869  1
2005 Perez-Ruixo JJ, Kimko HC, Chow AT, Piotrovsky V, Krzyzanski W, Jusko WJ. Population cell life span models for effects of drugs following indirect mechanisms of action. Journal of Pharmacokinetics and Pharmacodynamics. 32: 767-93. PMID 16328102 DOI: 10.1007/s10928-005-0019-1  1
2005 Almon RR, Dubois DC, Jin JY, Jusko WJ. Pharmacogenomic responses of rat liver to methylprednisolone: an approach to mining a rich microarray time series. The Aaps Journal. 7: E156-94. PMID 16146338 DOI: 10.1208/aapsj070117  1
2005 Krzyzanski W, Jusko WJ, Wacholtz MC, Minton N, Cheung WK. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after multiple subcutaneous doses in healthy subjects. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 26: 295-306. PMID 16102948 DOI: 10.1016/j.ejps.2005.06.010  1
2005 Samtani MN, Jusko WJ. Stability of dexamethasone sodium phosphate in rat plasma. International Journal of Pharmaceutics. 301: 262-6. PMID 16054309 DOI: 10.1016/j.ijpharm.2005.06.003  1
2005 Almon RR, Lai W, DuBois DC, Jusko WJ. Corticosteroid-regulated genes in rat kidney: mining time series array data. American Journal of Physiology. Endocrinology and Metabolism. 289: E870-82. PMID 15985454 DOI: 10.1152/ajpendo.00196.2005  1
2005 Samtani MN, Lohle M, Grant A, Nathanielsz PW, Jusko WJ. Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1124-30. PMID 15860658 DOI: 10.1124/dmd.105.004309  1
2005 Mager DE, Neuteboom B, Jusko WJ. Pharmacokinetics and pharmacodynamics of PEGylated IFN-beta 1a following subcutaneous administration in monkeys. Pharmaceutical Research. 22: 58-61. PMID 15771230 DOI: 10.1007/s11095-004-9009-z  1
2005 Chakraborty A, Yeung S, Pyszczynski NA, Jusko WJ. Pharmacodynamic interactions between recombinant mouse interleukin-10 and prednisolone using a mouse endotoxemia model. Journal of Pharmaceutical Sciences. 94: 590-603. PMID 15666292 DOI: 10.1002/jps.20257  0.84
2005 Samtani MN, Jusko WJ. Comparison of dexamethasone pharmacokinetics in female rats after intravenous and intramuscular administration. Biopharmaceutics & Drug Disposition. 26: 85-91. PMID 15654687 DOI: 10.1002/bdd.435  1
2005 Almon RR, Dubois DC, Jin JY, Jusko WJ. Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle. The Journal of Endocrinology. 184: 219-32. PMID 15642798 DOI: 10.1677/joe.1.05953  1
2004 Earp J, Krzyzanski W, Chakraborty A, Zamacona MK, Jusko WJ. Assessment of drug interactions relevant to pharmacodynamic indirect response models. Journal of Pharmacokinetics and Pharmacodynamics. 31: 345-80. PMID 15669772 DOI: 10.1007/s10928-004-8319-4  1
2004 Samtani MN, Schwab M, Nathanielsz PW, Jusko WJ. Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats. Pharmaceutical Research. 21: 2279-92. PMID 15648260 DOI: 10.1007/s11095-004-7681-7  1
2004 Ramakrishnan R, Cheung WK, Wacholtz MC, Minton N, Jusko WJ. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after single and multiple doses in healthy volunteers. Journal of Clinical Pharmacology. 44: 991-1002. PMID 15317827 DOI: 10.1177/0091270004268411  1
2004 Smith PF, Bullock JM, Booker BM, Haas CE, Berenson CS, Jusko WJ. Induction of imatinib metabolism by hypericum perforatum. Blood. 104: 1229-30. PMID 15294859 DOI: 10.1182/blood-2004-04-1240  1
2004 Lima JJ, Matsushima N, Kissoon N, Wang J, Sylvester JE, Jusko WJ. Modeling the metabolic effects of terbutaline in beta2-adrenergic receptor diplotypes. Clinical Pharmacology and Therapeutics. 76: 27-37. PMID 15229461 DOI: 10.1016/j.clpt.2004.03.006  1
2004 Almon RR, DuBois DC, Piel WH, Jusko WJ. The genomic response of skeletal muscle to methylprednisolone using microarrays: tailoring data mining to the structure of the pharmacogenomic time series. Pharmacogenomics. 5: 525-52. PMID 15212590 DOI: 10.1517/14622416.5.5.525  1
2004 Samtani MN, Schwab M, Nathanielsz PW, Jusko WJ. Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma. Journal of Pharmaceutical Sciences. 93: 726-32. PMID 14762910 DOI: 10.1002/jps.10577  1
2004 Jin JY, DuBois DC, Almon RR, Jusko WJ. Receptor/gene-mediated pharmacodynamic effects of methylprednisolone on phosphoenolpyruvate carboxykinase regulation in rat liver. The Journal of Pharmacology and Experimental Therapeutics. 309: 328-39. PMID 14722324 DOI: 10.1124/jpet.103.061515  1
2004 Chen J, Zhao P, Massaro D, Clerch LB, Almon RR, DuBois DC, Jusko WJ, Hoffman EP. The PEPR GeneChip data warehouse, and implementation of a dynamic time series query tool (SGQT) with graphical interface. Nucleic Acids Research. 32: D578-81. PMID 14681485 DOI: 10.1093/nar/gkh003  1
2003 Almon RR, Chen J, Snyder G, DuBois DC, Jusko WJ, Hoffman EP. In vivo multi-tissue corticosteroid microarray time series available online at Public Expression Profile Resource (PEPR). Pharmacogenomics. 4: 791-9. PMID 14596642 DOI: 10.1517/phgs.4.6.791.22816  1
2003 Mager DE, Lin SX, Blum RA, Lates CD, Jusko WJ. Dose equivalency evaluation of major corticosteroids: pharmacokinetics and cell trafficking and cortisol dynamics. Journal of Clinical Pharmacology. 43: 1216-27. PMID 14551176 DOI: 10.1177/0091270003258651  1
2003 Almon RR, DuBois DC, Pearson KE, Stephan DA, Jusko WJ. Gene arrays and temporal patterns of drug response: corticosteroid effects on rat liver. Functional & Integrative Genomics. 3: 171-9. PMID 12928814 DOI: 10.1007/s10142-003-0090-x  1
2003 Mager DE, Moledina N, Jusko WJ. Relative immunosuppressive potency of therapeutic corticosteroids measured by whole blood lymphocyte proliferation. Journal of Pharmaceutical Sciences. 92: 1521-5. PMID 12820156 DOI: 10.1002/jps.10402  1
2003 Jin JY, Almon RR, DuBois DC, Jusko WJ. Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays. The Journal of Pharmacology and Experimental Therapeutics. 307: 93-109. PMID 12808002 DOI: 10.1124/jpet.103.053256  1
2003 Levy G, Mager DE, Cheung WK, Jusko WJ. Comparative pharmacokinetics of coumarin anticoagulants L: Physiologic modeling of S-warfarin in rats and pharmacologic target-mediated warfarin disposition in man. Journal of Pharmaceutical Sciences. 92: 985-94. PMID 12712418 DOI: 10.1002/jps.10345  1
2003 Mager DE, Wyska E, Jusko WJ. Diversity of mechanism-based pharmacodynamic models. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 510-8. PMID 12695336 DOI: 10.1124/dmd.31.5.510  1
2003 Ramakrishnan R, Cheung WK, Farrell F, Joffee L, Jusko WJ. Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous dose administration in cynomolgus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 306: 324-31. PMID 12676891 DOI: 10.1124/jpet.102.047191  1
2003 Mager DE, Pyszczynski NA, Jusko WJ. Integrated QSPR--pharmacodynamic model of genomic effects of several corticosteroids. Journal of Pharmaceutical Sciences. 92: 881-9. PMID 12661073 DOI: 10.1002/jps.10343  1
2003 Mager DE, Neuteboom B, Efthymiopoulos C, Munafo A, Jusko WJ. Receptor-mediated pharmacokinetics and pharmacodynamics of interferon-beta1a in monkeys. The Journal of Pharmacology and Experimental Therapeutics. 306: 262-70. PMID 12660309 DOI: 10.1124/jpet.103.049502  1
2002 Mager DE, Jusko WJ. Receptor-mediated pharmacokinetic/pharmacodynamic model of interferon-beta 1a in humans. Pharmaceutical Research. 19: 1537-43. PMID 12425473 DOI: 10.1023/A:1020468902694  1
2002 Mager DE, Jusko WJ. Quantitative structure-pharmacokinetic/pharmacodynamic relationships of corticosteroids in man. Journal of Pharmaceutical Sciences. 91: 2441-51. PMID 12379930 DOI: 10.1002/jps.10231  1
2002 Almon RR, DuBois DC, Brandenburg EH, Shi W, Zhang S, Straubinger RM, Jusko WJ. Pharmacodynamics and pharmacogenomics of diverse receptor-mediated effects of methylprednisolone in rats using microarray analysis. Journal of Pharmacokinetics and Pharmacodynamics. 29: 103-29. PMID 12361239 DOI: 10.1023/A:1019762323576  1
2002 Ramakrishnan R, DuBois DC, Almon RR, Pyszczynski NA, Jusko WJ. Fifth-generation model for corticosteroid pharmacodynamics: application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats. Journal of Pharmacokinetics and Pharmacodynamics. 29: 1-24. PMID 12194533 DOI: 10.1023/A:1015765201129  1
2002 Ramakrishnan R, DuBois DC, Almon RR, Pyszczynski NA, Jusko WJ. Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats. The Journal of Pharmacology and Experimental Therapeutics. 300: 245-56. PMID 11752123 DOI: 10.1124/jpet.300.1.245  1
2001 Mager DE, Jusko WJ. General pharmacokinetic model for drugs exhibiting target-mediated drug disposition. Journal of Pharmacokinetics and Pharmacodynamics. 28: 507-32. PMID 11999290 DOI: 10.1023/A:1014414520282  1
2001 Ramakrishnan R, Jusko WJ. Interactions of aspirin and salicylic acid with prednisolone for inhibition of lymphocyte proliferation. International Immunopharmacology. 1: 2035-42. PMID 11606034 DOI: 10.1016/S1567-5769(01)00132-1  1
2001 Mager DE, Jusko WJ. Pharmacodynamic modeling of time-dependent transduction systems. Clinical Pharmacology and Therapeutics. 70: 210-6. PMID 11557908 DOI: 10.1067/mcp.2001.118244  1
1999 Krzyzanski W, Ramakrishnan R, Jusko WJ. Basic pharmacodynamic models for agents that alter production of natural cells. Journal of Pharmacokinetics and Biopharmaceutics. 27: 467-89. PMID 10948694  1
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