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Peter B. Madrid, Ph.D. - Publications

Affiliations: 
2005 University of California, San Francisco, San Francisco, CA 
Area:
Pharmaceutical Chemistry
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Gawriljuk VO, Zin PPK, Puhl AC, Zorn KM, Foil DH, Lane TR, Hurst B, Tavella TA, Costa FTM, Lakshmanane P, Bernatchez J, Godoy AS, Oliva G, Siqueira-Neto JL, Madrid PB, et al. Machine Learning Models Identify Inhibitors of SARS-CoV-2. Journal of Chemical Information and Modeling. PMID 34387990 DOI: 10.1021/acs.jcim.1c00683  0.324
2021 Puhl AC, Fritch EJ, Lane TR, Tse LV, Yount BL, Sacramento CQ, Fintelman-Rodrigues N, Tavella TA, Maranhão Costa FT, Weston S, Logue J, Frieman M, Premkumar L, Pearce KH, Hurst BL, ... ... Madrid PB, et al. Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: Activity against SARS-CoV-2 and Potential Mechanisms. Acs Omega. 6: 7454-7468. PMID 33778258 DOI: 10.1021/acsomega.0c05996  0.346
2020 Puhl AC, Fritch EJ, Lane TR, Tse LV, Yount BL, Sacramento CQ, Tavella TA, Costa FTM, Weston S, Logue J, Frieman M, Premkumar L, Pearce KH, Hurst BL, Andrade CH, ... ... Madrid P, et al. Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms. Biorxiv : the Preprint Server For Biology. PMID 33299990 DOI: 10.1101/2020.12.01.407361  0.321
2020 Lane TR, Dyall J, Mercer L, Goodin C, Foil DH, Zhou H, Postnikova E, Liang JY, Holbrook MR, Madrid PB, Ekins S. Repurposing Pyramax®, Quinacrine and Tilorone as Treatments for Ebola Virus Disease. Antiviral Research. 104908. PMID 32798602 DOI: 10.1016/J.Antiviral.2020.104908  0.379
2020 Lane TR, Massey C, Comer JE, Freiberg AN, Zhou H, Dyall J, Holbrook MR, Anantpadma M, Davey RA, Madrid PB, Ekins S. Pyronaridine Tetraphosphate Efficacy Against Ebola Virus Infection in Guinea Pig. Antiviral Research. 104863. PMID 32682926 DOI: 10.1016/J.Antiviral.2020.104863  0.359
2020 Ekins S, Lane TR, Madrid PB. Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond. Pharmaceutical Research. 37: 71. PMID 32215760 DOI: 10.1007/S11095-020-02799-8  0.366
2020 Ekins S, Madrid PB. Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses. Antimicrobial Agents and Chemotherapy. PMID 32205350 DOI: 10.1128/Aac.00440-20  0.385
2019 Lane TR, Massey C, Comer JE, Anantpadma M, Freundlich JS, Davey RA, Madrid PB, Ekins S. Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection. Plos Neglected Tropical Diseases. 13: e0007890. PMID 31751347 DOI: 10.1371/Journal.Pntd.0007890  0.338
2019 Lane TR, Comer JE, Freiberg AN, Madrid PB, Ekins S. Repurposing Quinacrine Against Ebola Virus Infection . Antimicrobial Agents and Chemotherapy. PMID 31307979 DOI: 10.1128/Aac.01142-19  0.366
2019 Lane T, Anantpadma M, Freundlich JS, Davey RA, Madrid PB, Ekins S. The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro. Pharmaceutical Research. 36: 104. PMID 31101988 DOI: 10.1007/S11095-019-2629-0  0.32
2019 Anantpadma M, Lane T, Zorn KM, Lingerfelt MA, Clark AM, Freundlich JS, Davey RA, Madrid PB, Ekins S. Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads. Acs Omega. 4: 2353-2361. PMID 30729228 DOI: 10.1021/acsomega.8b02948  0.365
2017 Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB. Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection. Antimicrobial Agents and Chemotherapy. PMID 29133569 DOI: 10.1128/Aac.01711-17  0.36
2016 Djaout K, Singh V, Boum Y, Katawera V, Becker HF, Bush NG, Hearnshaw SJ, Pritchard JE, Bourbon P, Madrid PB, Maxwell A, Mizrahi V, Myllykallio H, Ekins S. Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis. Scientific Reports. 6: 27792. PMID 27283217 DOI: 10.1038/Srep27792  0.319
2016 Ekins S, Freundlich JS, Clark AM, Anantpadma M, Davey RA, Madrid P. Machine learning models identify molecules active against the Ebola virus in vitro F1000research. 4: 1091. DOI: 10.12688/f1000research.7217.2  0.366
2016 Madrid PB, Panchal RG, Warren TK, Shurtleff AC, Endsley AN, Green CE, Kolokoltsov A, Davey R, Manger ID, Gilfillan L, Bavari S, Tanga MJ. Evaluation of Ebola Virus Inhibitors for Drug Repurposing Acs Infectious Diseases. 1: 317-326. DOI: 10.1021/acsinfecdis.5b00030  0.323
2015 Madrid PB, Panchal RG, Warren TK, Shurtleff AC, Endsley AN, Green CE, Kolokoltsov A, Davey R, Manger ID, Gilfillan L, Bavari S, Tanga MJ. Evaluation of Ebola Virus Inhibitors for Drug Repurposing. Acs Infectious Diseases. 1: 317-26. PMID 27622822 DOI: 10.1021/Acsinfecdis.5B00030  0.421
2015 Ekins S, Freundlich JS, Clark AM, Anantpadma M, Davey RA, Madrid P. Machine learning models identify molecules active against the Ebola virus in vitro. F1000research. 4: 1091. PMID 26834994 DOI: 10.12688/F1000Research.7217.3  0.457
2015 Ekins S, Madrid PB, Sarker M, Li SG, Mittal N, Kumar P, Wang X, Stratton TP, Zimmerman M, Talcott C, Bourbon P, Travers M, Yadav M, Freundlich JS. Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery. Plos One. 10: e0141076. PMID 26517557 DOI: 10.1371/Journal.Pone.0141076  0.42
2013 Madrid PB, Chopra S, Manger ID, Gilfillan L, Keepers TR, Shurtleff AC, Green CE, Iyer LV, Dilks HH, Davey RA, Kolokoltsov AA, Carrion R, Patterson JL, Bavari S, Panchal RG, et al. A systematic screen of FDA-approved drugs for inhibitors of biological threat agents. Plos One. 8: e60579. PMID 23577127 DOI: 10.1371/Journal.Pone.0060579  0.42
2012 Chopra S, Matsuyama K, Tran T, Madrid P. Systematic discovery of synergistic novel antibiotic combinations targeting multidrug-resistant Acinetobacter baumannii. International Journal of Antimicrobial Agents. 40: 377-9. PMID 22858372 DOI: 10.1016/J.Ijantimicag.2012.06.008  0.333
2012 Chopra S, Koolpe GA, Tambo-Ong AA, Matsuyama KN, Ryan KJ, Tran TB, Doppalapudi RS, Riccio ES, Iyer LV, Green CE, Wan B, Franzblau SG, Madrid PB. Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis. Journal of Medicinal Chemistry. 55: 6047-60. PMID 22691154 DOI: 10.1021/Jm300123S  0.479
2012 Culyba M, Hwang Y, Attar S, Madrid PB, Bupp J, Huryn D, Sanchez L, Grobler J, Miller MD, Bushman FD. Bulged DNA substrates for identifying poxvirus resolvase inhibitors. Nucleic Acids Research. 40: e124. PMID 22581770 DOI: 10.1093/Nar/Gks325  0.324
2012 Sarker M, Talcott C, Madrid P, Chopra S, Bunin BA, Lamichhane G, Freundlich JS, Ekins S. Combining cheminformatics methods and pathway analysis to identify molecules with whole-cell activity against Mycobacterium tuberculosis. Pharmaceutical Research. 29: 2115-27. PMID 22477069 DOI: 10.1007/S11095-012-0741-5  0.409
2012 Chopra S, Matsuyama K, Tran T, Malerich JP, Wan B, Franzblau SG, Lun S, Guo H, Maiga MC, Bishai WR, Madrid PB. Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis Journal of Antimicrobial Chemotherapy. 67: 415-421. PMID 22052686 DOI: 10.1093/Jac/Dkr449  0.358
2011 Tambo-ong A, Chopra S, Glaser BT, Matsuyama K, Tran T, Madrid PB. Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities. Bioorganic & Medicinal Chemistry Letters. 21: 5697-700. PMID 21871799 DOI: 10.1016/J.Bmcl.2011.08.035  0.394
2011 Chopra S, Matsuyama K, Hutson C, Madrid P. Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae. The Journal of Antimicrobial Chemotherapy. 66: 1533-6. PMID 21486854 DOI: 10.1093/Jac/Dkr154  0.468
2011 Glaser BT, Malerich JP, Duellman SJ, Fong J, Hutson C, Fine RM, Keblansky B, Tang MJ, Madrid PB. A high-throughput fluorescence polarization assay for inhibitors of gyrase B. Journal of Biomolecular Screening. 16: 230-8. PMID 21245469 DOI: 10.1177/1087057110392038  0.398
2011 Klöck C, Jin X, Choi K, Khosla C, Madrid PB, Spencer A, Raimundo BC, Boardman P, Lanza G, Griffin JH. Acylideneoxoindoles: a new class of reversible inhibitors of human transglutaminase 2. Bioorganic & Medicinal Chemistry Letters. 21: 2692-6. PMID 21215619 DOI: 10.1016/J.Bmcl.2010.12.037  0.384
2010 Chopra S, Torres-Ortiz M, Hokama L, Madrid P, Tanga M, Mortelmans K, Kodukula K, Galande AK. Repurposing FDA-approved drugs to combat drug-resistant Acinetobacter baumannii. The Journal of Antimicrobial Chemotherapy. 65: 2598-601. PMID 20861141 DOI: 10.1093/Jac/Dkq353  0.432
2010 Laderoute KR, Calaoagan JM, Madrid PB, Klon AE, Ehrlich PJ. SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK). Cancer Biology & Therapy. 10: 68-76. PMID 20495370 DOI: 10.4161/Cbt.10.1.12162  0.351
2010 Zhou W, Madrid P, Fluitt A, Stahl A, Xie XS. Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5. Journal of Biomolecular Screening. 15: 488-97. PMID 20448275 DOI: 10.1177/1087057110369700  0.385
2010 Ray S, Madrid PB, Catz P, LeValley SE, Furniss MJ, Rausch LL, Guy RK, DeRisi JL, Iyer LV, Green CE, Mirsalis JC. Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models. Journal of Medicinal Chemistry. 53: 3685-95. PMID 20361799 DOI: 10.1021/Jm100057H  0.631
2008 Madrid PB, Liou AP, DeRisi JL, Guy RK. Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum (Journal of Medical Chemistry (2006) 49 (4540)) Journal of Medicinal Chemistry. 51: 699. DOI: 10.1021/jm701572a  0.483
2007 Warhurst DC, Craig JC, Adagu IS, Guy RK, Madrid PB, Fivelman QL. Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases. Biochemical Pharmacology. 73: 1910-26. PMID 17466277 DOI: 10.1016/J.Bcp.2007.03.011  0.512
2006 Mayer M, Lang PT, Gerber S, Madrid PB, Pinto IG, Guy RK, James TL. Synthesis and testing of a focused phenothiazine library for binding to HIV-1 TAR RNA. Chemistry & Biology. 13: 993-1000. PMID 16984889 DOI: 10.1016/J.Chembiol.2006.07.009  0.485
2006 May BC, Witkop J, Sherrill J, Anderson MO, Madrid PB, Zorn JA, Prusiner SB, Cohen FE, Guy RK. Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells. Bioorganic & Medicinal Chemistry Letters. 16: 4913-6. PMID 16860557 DOI: 10.1016/J.Bmcl.2006.06.050  0.634
2006 Madrid PB, Liou AP, DeRisi JL, Guy RK. Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum. Journal of Medicinal Chemistry. 49: 4535-43. PMID 16854059 DOI: 10.1021/Jm0600951  0.599
2006 Anderson MO, Sherrill J, Madrid PB, Liou AP, Weisman JL, DeRisi JL, Guy RK. Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 14: 334-43. PMID 16216519 DOI: 10.1016/J.Bmc.2005.08.017  0.679
2005 Madrid PB, Sherrill J, Liou AP, Weisman JL, Derisi JL, Guy RK. Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities. Bioorganic & Medicinal Chemistry Letters. 15: 1015-8. PMID 15686903 DOI: 10.1016/J.Bmcl.2004.12.037  0.551
2004 Madrid PB, Wilson NT, DeRisi JL, Guy RK. Parallel synthesis and antimalarial screening of a 4-aminoquinoline library. Journal of Combinatorial Chemistry. 6: 437-42. PMID 15132606 DOI: 10.1021/Cc0340473  0.627
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