| Year |
Citation |
Score |
| 2023 |
Lynn ML, Jimenez J, Castillo RL, Klass MM, Vasquez C, Baldo A, Gibson C, Murphy AM, Tardiff JC. The HCM - Linked Mutation Arg92Leu in TNNT2 Allosterically Alters the cTnC - cTnI Interface and Disrupts the PKA-mediated Regulation of Myofilament Relaxation. Biorxiv : the Preprint Server For Biology. PMID 37503299 DOI: 10.1101/2023.07.18.549569 |
0.46 |
|
| 2023 |
Lehman SJ, Meller A, Solieva SO, Lotthammer JM, Greenberg L, Langer SJ, Greenberg MJ, Tardiff JC, Bowman GR, Leinwand L. Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies. Biorxiv : the Preprint Server For Biology. PMID 37461648 DOI: 10.1101/2023.07.03.547580 |
0.495 |
|
| 2022 |
Chakraborti A, Tardiff JC, Schwartz SD. Insights into the Mechanism of the Cardiac Drug Omecamtiv Mecarbil─A Computational Study. The Journal of Physical Chemistry. B. PMID 36448224 DOI: 10.1021/acs.jpcb.2c06679 |
0.331 |
|
| 2022 |
Keyt LK, Duran JM, Bui QM, Chen C, Miyamoto MI, Silva Enciso J, Tardiff JC, Adler ED. Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics. Frontiers in Cardiovascular Medicine. 9: 972301. PMID 36158814 DOI: 10.3389/fcvm.2022.972301 |
0.496 |
|
| 2022 |
Deranek AE, Baldo AP, Lynn ML, Schwartz SD, Tardiff JC. Structure and Dynamics of the Flexible Cardiac Troponin T Linker Domain in a Fully Reconstituted Thin Filament. Biochemistry. PMID 35696530 DOI: 10.1021/acs.biochem.2c00091 |
0.332 |
|
| 2022 |
Pioner JM, Vitale G, Gentile F, Scellini B, Piroddi N, Cerbai E, Olivotto I, Tardiff J, Coppini R, Tesi C, Poggesi C, Ferrantini C. Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different Mutations. Frontiers in Physiology. 13: 864547. PMID 35514357 DOI: 10.3389/fphys.2022.864547 |
0.4 |
|
| 2021 |
Mason AB, Lynn ML, Baldo AP, Deranek AE, Tardiff JC, Schwartz SD. Computational and biophysical determination of pathogenicity of variants of unknown significance in cardiac thin filament. Jci Insight. PMID 34699384 DOI: 10.1172/jci.insight.154350 |
0.368 |
|
| 2021 |
Chakraborti A, Baldo AP, Tardiff JC, Schwartz SD. Investigation of the Recovery Stroke and ATP Hydrolysis and Changes Caused Due to the Cardiomyopathic Point Mutations in Human Cardiac β Myosin. The Journal of Physical Chemistry. B. PMID 34105970 DOI: 10.1021/acs.jpcb.1c03144 |
0.378 |
|
| 2021 |
Greenberg MJ, Tardiff JC. Complexity in genetic cardiomyopathies and new approaches for mechanism-based precision medicine. The Journal of General Physiology. 153. PMID 33512404 DOI: 10.1085/jgp.202012662 |
0.383 |
|
| 2020 |
Powers JD, Kooiker KB, Mason AB, Teitgen AE, Flint GV, Tardiff JC, Schwartz SD, McCulloch AD, Regnier M, Davis J, Moussavi-Harami F. Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts. Jci Insight. PMID 32931484 DOI: 10.1172/Jci.Insight.142446 |
0.475 |
|
| 2020 |
Chowdhury SAK, Warren CM, Simon JN, Ryba DM, Batra A, Varga P, Kranias EG, Tardiff JC, Solaro RJ, Wolska BM. Modifications of Sarcoplasmic Reticulum Function Prevent Progression of Sarcomere-Linked Hypertrophic Cardiomyopathy Despite a Persistent Increase in Myofilament Calcium Response. Frontiers in Physiology. 11: 107. PMID 32210830 DOI: 10.3389/Fphys.2020.00107 |
0.469 |
|
| 2020 |
Marszalek R, Chowdhury SA, Hałas M, Batra A, Warren C, Tardiff J, Solaro R, Wolska B. CORONARY INSUFFICIENCY UNDERLIES FIBROTIC HCM PROGRESSION Journal of the American College of Cardiology. 75: 1045. DOI: 10.1016/S0735-1097(20)31672-7 |
0.459 |
|
| 2020 |
Baldo AP, Tardiff JC, Schwartz SD. Computational Evaluation of Point Mutation Perturbations to the Recovery Stroke of Dictyostelium Myosin II with Metadynamics Biophysical Journal. 118: 436a. DOI: 10.1016/J.Bpj.2019.11.2446 |
0.378 |
|
| 2020 |
Chakraborti A, Tardiff JC, Schwartz SD. Computational Study of the Effect of Point Mutations Perturbing the Recovery Stroke of Human Cardiac Beta-Myosin using Metadynamics Biophysical Journal. 118: 435a-436a. DOI: 10.1016/J.Bpj.2019.11.2444 |
0.42 |
|
| 2020 |
Lynn ML, Grinspan L, Vasquez C, Holeman TA, Jin J, Tardiff JC. Intrinsic Modifier Effect of cTnT Isoform Switching in Sarcomeric Cardiomyopathies Biophysical Journal. 118: 427a. DOI: 10.1016/J.Bpj.2019.11.2400 |
0.693 |
|
| 2020 |
Smith AB, Baldo AP, Tardiff JC, Schwartz SD. Classification of Genetic Cardiac Mutations Using Computational Chemistry Biophysical Journal. 118: 426a-427a. DOI: 10.1016/J.Bpj.2019.11.2398 |
0.503 |
|
| 2020 |
Deranek AE, Baldo A, Vasquez C, Schwartz SD, Tardiff JC. Defining the Flexible Cardiac Troponin T Linker Region in Relationship to Actin and Determining Effects of Pathogenic Point Mutations Biophysical Journal. 118: 423a-424a. DOI: 10.1016/J.Bpj.2019.11.2385 |
0.552 |
|
| 2020 |
Klass MM, Heffernon G, Hauck G, Lehman S, Davis JP, Tardiff JC. Stopped-Flow Calcium Kinetics of Hypertrophic Cardiomyopathy-Associated Troponin T Mutations Biophysical Journal. 118: 327a. DOI: 10.1016/J.Bpj.2019.11.1834 |
0.448 |
|
| 2020 |
Munusamy E, Schwartz SD, Tardiff JC. A Molecular Dynamics Study of Small Molecules Bound to a Full Atomistic Model of Cardiac Thin Filament as a Method to Identify Possible Treatments for Genetic Cardiomyopathies Biophysical Journal. 118: 326a. DOI: 10.1016/J.Bpj.2019.11.1830 |
0.343 |
|
| 2019 |
Abdullah S, Lynn ML, McConnell MT, Klass MM, Baldo AP, Schwartz SD, Tardiff JC. FRET-based analysis of the cardiac troponin T linker region reveals the structural basis of the hypertrophic cardiomyopathy-causing Δ160E mutation. The Journal of Biological Chemistry. PMID 31387947 DOI: 10.1074/Jbc.Ra118.005098 |
0.644 |
|
| 2019 |
Szatkowski L, Lynn ML, Holeman T, Williams MR, Baldo AP, Tardiff JC, Schwartz SD. Proof of Principle that Molecular Modeling Followed by a Biophysical Experiment Can Develop Small Molecules that Restore Function to the Cardiac Thin Filament in the Presence of Cardiomyopathic Mutations. Acs Omega. 4: 6492-6501. PMID 31342001 DOI: 10.1021/acsomega.8b03340 |
0.385 |
|
| 2019 |
Deranek AE, Klass MM, Tardiff JC. Moving beyond simple answers to complex disorders in sarcomeric cardiomyopathies: the role of integrated systems. Pflugers Archiv : European Journal of Physiology. PMID 30848350 DOI: 10.1007/S00424-019-02269-0 |
0.486 |
|
| 2019 |
Kooiker KB, Powers JD, Tardiff J, Regnier M, Davis J, Moussavi-Harami F. Engineered Thin Filament Mutation to Increase Calcium Sensitivity of Force in Tropomyosin Mutation of Dilated Cardiomyopathy Biophysical Journal. 116: 115a-116a. DOI: 10.1016/J.Bpj.2018.11.651 |
0.522 |
|
| 2019 |
Deranek AE, Baldo A, Schwartz S, Tardiff JC. Computational and Experimental Investigation of Cardiac Troponin T R173Q, R173W and Δ160E Mutation Specific Correlates to Disease Biophysical Journal. 116: 265a. DOI: 10.1016/J.Bpj.2018.11.1438 |
0.511 |
|
| 2018 |
Lehman SJ, Tal-Grinspan L, Lynn ML, Strom J, Benitez GE, Anderson ME, Tardiff JC. Chronic Calmodulin-Kinase II Activation Drives Disease Progression in Mutation-Specific Hypertrophic Cardiomyopathy. Circulation. PMID 30586744 DOI: 10.1161/Circulationaha.118.034549 |
0.535 |
|
| 2018 |
Lynn ML, Lehman SJ, Tardiff JC. Biophysical Derangements in Genetic Cardiomyopathies. Heart Failure Clinics. 14: 147-159. PMID 29525644 DOI: 10.1016/J.Hfc.2017.12.002 |
0.386 |
|
| 2018 |
Chowdhury S, Simon J, Ryba D, Begum N, Kranias E, Tardiff J, John Solaro R, Wolska B. Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in troponin T, via reduced expression of phospholamban Journal of Molecular and Cellular Cardiology. 124: 115-116. DOI: 10.1016/J.Yjmcc.2018.07.097 |
0.452 |
|
| 2018 |
Baldo A, Abdullah S, Deranek A, Lynn M, Williams M, Tardiff JC, Schwartz SD. Computational and Experimental Studies of Divergent Clinical Effects in Proximate Thin Filament Mutations Biophysical Journal. 114: 568a-569a. DOI: 10.1016/J.Bpj.2017.11.3110 |
0.464 |
|
| 2018 |
Klass MM, Lehman SJ, Tardiff JC. Stopped-Flow Calcium Association Kinetics of Hypertrophic Cardiomyopathy Associated Troponin T Mutations Biophysical Journal. 114: 501a-502a. DOI: 10.1016/J.Bpj.2017.11.2742 |
0.432 |
|
| 2018 |
Deranek A, Baldo A, Lynn ML, McConnell MT, Williams MR, Schwartz SD, Tardiff JC. Computational and Experimental Investigation of Tropomyosin D230N and S215l Mutation Specific Correlates to Disease Biophysical Journal. 114: 499a. DOI: 10.1016/J.Bpj.2017.11.2731 |
0.469 |
|
| 2018 |
Holeman TA, Lynn ML, Tardiff JC. Unique Structural and Functional Effects of Alpha-Tropomyosin Mutations in HCM and DCM Biophysical Journal. 114: 498a. DOI: 10.1016/J.Bpj.2017.11.2725 |
0.476 |
|
| 2018 |
Powers JD, Moussavi-Harami F, Tardiff JC, Davis J, Regnier M. Engineered Thin Filament Mutations to Study the Sarcomere Length Dependence of Cardiac Muscle Contractility Biophysical Journal. 114: 313a-314a. DOI: 10.1016/J.Bpj.2017.11.1769 |
0.479 |
|
| 2017 |
Ferrantini C, Coppini R, Pioner JM, Gentile F, Tosi B, Mazzoni L, Scellini B, Piroddi N, Laurino A, Santini L, Spinelli V, Sacconi L, De Tombe P, Moore R, Tardiff J, et al. Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models. Journal of the American Heart Association. 6. PMID 28735292 DOI: 10.1161/Jaha.116.005407 |
0.524 |
|
| 2017 |
McConnell M, Tal Grinspan L, Williams MR, Lynn ML, Schwartz BA, Fass OZ, Schwartz SD, Tardiff JC. Clinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap. Biochemistry. PMID 28603979 DOI: 10.1021/Acs.Biochem.7B00266 |
0.626 |
|
| 2017 |
Lynn ML, Tal Grinspan L, Holeman TA, Jimenez J, Strom J, Tardiff JC. The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. PMID 28600229 DOI: 10.1016/J.Yjmcc.2017.06.001 |
0.588 |
|
| 2017 |
Coppini R, Mazzoni L, Ferrantini C, Gentile F, Pioner JM, Laurino T, Santini L, Bargelli V, Rotellini M, Bartolucci G, Crocini C, Sacconi L, Tesi C, Belardinelli L, Tardiff J, et al. Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy. Circulation. Heart Failure. 10. PMID 28255011 DOI: 10.1161/Circheartfailure.116.003565 |
0.482 |
|
| 2017 |
Steczina S, Olafsson S, Flint G, Tardiff J, Regnier M, Moussavi-Harami F. Recovery of Calcium Activity and Contraction in Models of Dilated Cardiomyopathy Biophysical Journal. 112: 165a. DOI: 10.1016/J.Bpj.2016.11.910 |
0.382 |
|
| 2017 |
Powers JD, Moussavi-Harami F, Razumova M, Tardiff J, Regnier M. The Frank-Starling Mechansim is Attenuated by a Dilated Cardiomyopathy-Associated Tropomyosin Mutation Biophysical Journal. 112: 120a. DOI: 10.1016/J.Bpj.2016.11.673 |
0.448 |
|
| 2017 |
Ferrantini C, Manuel Pioner J, Gentile F, Coppini R, Morelli C, Piroddi N, Scellini B, Cerbai E, Tardiff J, Tesi C, Olivotto I, Poggesi C. Atrial Remodeling in Hypertrophic Cardiomyopathy Biophysical Journal. 112: 556a. DOI: 10.1016/J.Bpj.2016.11.3000 |
0.539 |
|
| 2017 |
Lynn M, Holeman T, Grinspan L, Jin J, Tardiff J. cTnT isoform Switching in the Development of Early Childhood Tropomyosin-Linked DCM Biophysical Journal. 112: 256a. DOI: 10.1016/J.Bpj.2016.11.1397 |
0.678 |
|
| 2017 |
Lehman S, Grinspan L, Anderson ME, Tardiff JC. Differential CaMK-II Activation in the Progression of HCM in cTnT Mutations Biophysical Journal. 112: 256a. DOI: 10.1016/J.Bpj.2016.11.1396 |
0.762 |
|
| 2016 |
Tardiff JC. The Role of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Hypertrophic Cardiomyopathy. Circulation. 134: 1749-1751. PMID 27895024 DOI: 10.1161/Circulationaha.116.025455 |
0.505 |
|
| 2016 |
Jian Z, Chen YJ, Shimkunas R, Jian Y, Jaradeh M, Chavez K, Chiamvimonvat N, Tardiff JC, Izu LT, Ross RS, Chen-Izu Y. In Vivo Cannulation Methods for Cardiomyocytes Isolation from Heart Disease Models. Plos One. 11: e0160605. PMID 27500929 DOI: 10.1371/Journal.Pone.0160605 |
0.34 |
|
| 2016 |
Behunin SM, Lopez-Pier MA, Mayfield RM, Danilo CA, Lipovka Y, Birch C, Lehman S, Tardiff JC, Gregorio CC, Konhilas JP. Liver Kinase B 1 Complex Acts as a Novel Modifier of Myofilament Function and Localizes to the Z-Disk in Cardiac Myocytes. Archives of Biochemistry and Biophysics. PMID 26971467 DOI: 10.1016/J.Abb.2016.03.012 |
0.335 |
|
| 2016 |
Williams MR, Lehman SJ, Tardiff JC, Schwartz SD. Atomic resolution probe for allostery in the regulatory thin filament. Proceedings of the National Academy of Sciences of the United States of America. PMID 26957598 DOI: 10.1073/Pnas.1519541113 |
0.553 |
|
| 2016 |
Pioner JM, Gentile F, Coppini R, Scellini B, Tardiff J, Tesi C, Poggesi C, Ferrantini C. Mechanical Remodeling of Atrial Myocardium in HCM Mouse Models Carrying CTNT Mutations Biophysical Journal. 110: 599a-600a. DOI: 10.1016/J.Bpj.2015.11.3201 |
0.443 |
|
| 2016 |
McConnell MT, Tal Grinspan L, Schwartz B, Fass OZ, James Jayasundar J, Tardiff JC. A FRET Investigation on the Effects of Tropomyosin D230N and Cardiac Troponin T R92L Mutants on the Tropomyosin Overlap Structure Biophysical Journal. 110: 464a. DOI: 10.1016/J.Bpj.2015.11.2484 |
0.544 |
|
| 2016 |
Lehman SJ, Tal-Grinspan L, Lynn M, Anderson ME, Tardiff JC. Differential Effects of CaMKII Activity in HCM-Linked TNT Mutations Biophysical Journal. 110: 366a. DOI: 10.1016/J.Bpj.2015.11.1974 |
0.552 |
|
| 2015 |
Crocini C, Ferrantini C, Scardigli M, Coppini R, Mazzoni L, Lazzeri E, Pioner JM, Scellini B, Guo A, Song LS, Yan P, Loew LM, Tardiff J, Tesi C, Vanzi F, et al. Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology. PMID 26714042 DOI: 10.1016/J.Yjmcc.2015.12.013 |
0.409 |
|
| 2015 |
Hill MG, Sekhon MK, Reed KL, Anderson CF, Borjon ND, Tardiff JC, Barber BJ. Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation. Pediatric Cardiology. PMID 26337809 DOI: 10.1007/S00246-015-1250-1 |
0.34 |
|
| 2015 |
Sequeira V, Najafi A, McConnell M, Fowler ED, Bollen IA, Wüst RC, Remedios CD, Helmes M, White E, Stienen GJ, Tardiff J, Kuster DW, van der Velden J. Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness. The Journal of Physiology. PMID 26096258 DOI: 10.1113/Jp270354 |
0.376 |
|
| 2015 |
Gollapudi SK, Tardiff JC, Chandra M. The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and β-myosin heavy chain isoforms. American Journal of Physiology. Heart and Circulatory Physiology. 308: H884-93. PMID 25681424 DOI: 10.1152/Ajpheart.00528.2014 |
0.36 |
|
| 2015 |
Tardiff JC, Carrier L, Bers DM, Poggesi C, Ferrantini C, Coppini R, Maier LS, Ashrafian H, Huke S, van der Velden J. Targets for therapy in sarcomeric cardiomyopathies. Cardiovascular Research. 105: 457-70. PMID 25634554 DOI: 10.1093/Cvr/Cvv023 |
0.442 |
|
| 2015 |
van der Velden J, Ho CY, Tardiff JC, Olivotto I, Knollmann BC, Carrier L. Research priorities in sarcomeric cardiomyopathies. Cardiovascular Research. 105: 449-56. PMID 25631582 DOI: 10.1093/Cvr/Cvv019 |
0.535 |
|
| 2015 |
Duncker DJ, Bakkers J, Brundel BJ, Robbins J, Tardiff JC, Carrier L. Animal and in silico models for the study of sarcomeric cardiomyopathies. Cardiovascular Research. 105: 439-48. PMID 25600962 DOI: 10.1093/Cvr/Cvv006 |
0.301 |
|
| 2015 |
Moussavi-Harami F, Razumova MV, Cheng Y, Odom G, Teichman S, Tardiff J, Hauschka SD, Chamberlain JS, Murry CM, Regnier M. 11. Gene Therapy Mediated Increase in dATP Improves Cardiac Performance in Models of Systolic Heart Failure Molecular Therapy. 23: S5. DOI: 10.1016/S1525-0016(16)33615-2 |
0.428 |
|
| 2015 |
Williams MR, Lehman SJ, Tardiff JC, Schwartz SD. An Explicitly Solvated Full Atomistic Model of the Cardiac Thin Filament and Application on the Calcium Binding Affinity Effects from Familial Hypertrophic Cardiomyopathy Linked Mutations Biophysical Journal. 108: 447a. DOI: 10.1016/J.Bpj.2014.11.2441 |
0.456 |
|
| 2015 |
Tardiff J. An Integrative Approach to Thin Filament Cardiomyopathies: From Molecular and Computational Biophysics to Mice Biophysical Journal. 108: 34a-35a. DOI: 10.1016/J.Bpj.2014.11.216 |
0.487 |
|
| 2015 |
McConnell MT, Grinspan L, Tardiff J. Structural Effects of Cardiac Troponin T R92L and Tropomyosin D230N Mutants in the Cardiac Thin Filament Biophysical Journal. 108: 295a. DOI: 10.1016/J.Bpj.2014.11.1606 |
0.808 |
|
| 2015 |
Coppini R, Ferrantini C, Gentile F, Mazzoni L, Tosi B, Pioner MJ, Scellini B, Piroddi N, Tardiff JC, Tesi C, Cerbai E, Poggesi C. Myocardial Dysfunction in Hypertrophic Cardiomyopathy: Primary Effects of Sarcomeric Mutations Versus Secondary EC-Coupling Remodelling Biophysical Journal. 108: 293a. DOI: 10.1016/J.Bpj.2014.11.1596 |
0.532 |
|
| 2015 |
Hill MG, Sekhon MK, Reed KL, Anderson CF, Borjon ND, Tardiff JC, Barber BJ. Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation Pediatric Cardiology. DOI: 10.1007/s00246-015-1250-1 |
0.374 |
|
| 2014 |
Coppini R, Ho CY, Ashley E, Day S, Ferrantini C, Girolami F, Tomberli B, Bardi S, Torricelli F, Cecchi F, Mugelli A, Poggesi C, Tardiff J, Olivotto I. Clinical phenotype and outcome of hypertrophic cardiomyopathy associated with thin-filament gene mutations. Journal of the American College of Cardiology. 64: 2589-600. PMID 25524337 DOI: 10.1016/J.Jacc.2014.09.059 |
0.499 |
|
| 2014 |
Jian Z, Han H, Zhang T, Puglisi J, Izu LT, Shaw JA, Onofiok E, Erickson JR, Chen YJ, Horvath B, Shimkunas R, Xiao W, Li Y, Pan T, Chan J, ... ... Tardiff JC, et al. Mechanochemotransduction during cardiomyocyte contraction is mediated by localized nitric oxide signaling. Science Signaling. 7: ra27. PMID 24643800 DOI: 10.1126/Scisignal.2005046 |
0.352 |
|
| 2014 |
Moore RK, Abdullah S, Tardiff JC. Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: a novel pathogenic mechanism for hypertrophic cardiomyopathy. Archives of Biochemistry and Biophysics. 552: 21-8. PMID 24480310 DOI: 10.1016/J.Abb.2014.01.016 |
0.614 |
|
| 2014 |
Coppini R, Gentile F, Mazzoni L, Ferrantini C, Tosi B, Ferrara C, Tardiff J, Tesi C, Cerbai E, Poggesi C. 291Myocardial dysfunction in hypertrophic cardiomyopathy: primary effects of sarcomeric mutations versus secondary cardiomyocyte remodeling? Cardiovascular Research. 103: S53.2-S53. DOI: 10.1093/Cvr/Cvu087.5 |
0.427 |
|
| 2014 |
Pioner JM, Coppini R, Ferrantini C, Tosi B, Mazzoni L, Moore R, Cerbai E, Mugelli A, Tardiff J, Tesi C, Poggesi C. E-C Coupling Alterations and Spontaneous Activity in Mice Carrying Cardiac Troponin T Mutations Biophysical Journal. 106: 644a. DOI: 10.1016/J.Bpj.2013.11.3567 |
0.379 |
|
| 2014 |
McConnell MT, Jayasundar JJ, Grinspan L, Fass OZ, Schwartz B, Tardiff JC. Dynamic Effects of Tropomyosin D230N Mutation and Fetal Troponin T on the Tropomyosin Overlap Region Biophysical Journal. 106: 32a. DOI: 10.1016/J.Bpj.2013.11.250 |
0.809 |
|
| 2014 |
Williams MR, Tardiff J, Schwartz S. A Revised Atomistic Model of the Cardiac Thin Filament and Application to a Specific Disease Causing Mutation Biophysical Journal. 106: 32a. DOI: 10.1016/J.Bpj.2013.11.247 |
0.556 |
|
| 2014 |
Manning EP, Lehman SJ, Schwartz SD, Tardiff JC. Computational Prediction and Experimental Verification of Differential Calcium Affinity in Thin Filament Mutants Known to Cause Hypertrophic Cardiomyopathy Biophysical Journal. 106: 349a. DOI: 10.1016/J.Bpj.2013.11.1985 |
0.421 |
|
| 2014 |
Jayasundar JJ, Brooks K, Lehman S, Williams MR, Tardiff JC. The Cardiac Troponin T R92L Hcm Mutation Alters Cardiac Troponin I Dynamics and PKA Phosphorylation Potential Biophysical Journal. 106: 348a. DOI: 10.1016/J.Bpj.2013.11.1983 |
0.547 |
|
| 2013 |
Moore RK, Grinspan LT, Jimenez J, Guinto PJ, Ertz-Berger B, Tardiff JC. HCM-linked ∆160E cardiac troponin T mutation causes unique progressive structural and molecular ventricular remodeling in transgenic mice. Journal of Molecular and Cellular Cardiology. 58: 188-98. PMID 23434821 DOI: 10.1016/J.Yjmcc.2013.02.004 |
0.807 |
|
| 2013 |
Michael JJ, Tal L, Tardiff JC, Chandra M. Pseudophosphorylation of Cardiac Troponin I Residues 23/24 Decreases Myofilament Ca2+ Sensitivity in Transgenic Mice Containing D230N Mutation in α-Tropomyosin Biophysical Journal. 104: 482a. DOI: 10.1016/J.Bpj.2012.11.2663 |
0.457 |
|
| 2012 |
Tardiff JC. It's never too early to look: subclinical disease in sarcomeric dilated cardiomyopathy. Circulation. Cardiovascular Genetics. 5: 483-6. PMID 23074334 DOI: 10.1161/Circgenetics.112.964817 |
0.579 |
|
| 2012 |
He H, Hoyer K, Tao H, Rice R, Jimenez J, Tardiff JC, Ingwall JS. Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific. The Journal of Physiology. 590: 5371-88. PMID 22907055 DOI: 10.1113/Jphysiol.2012.234252 |
0.724 |
|
| 2012 |
Ford SJ, Mamidi R, Jimenez J, Tardiff JC, Chandra M. Effects of R92 mutations in mouse cardiac troponin T are influenced by changes in myosin heavy chain isoform. Journal of Molecular and Cellular Cardiology. 53: 542-51. PMID 22884844 DOI: 10.1016/J.Yjmcc.2012.07.018 |
0.604 |
|
| 2012 |
Leinwand LA, Tardiff JC, Gregorio CC. Mutations in the sensitive giant titin result in a broken heart. Circulation Research. 111: 158-61. PMID 22773424 DOI: 10.1161/Res.0B013E3182635Ca2 |
0.504 |
|
| 2012 |
Manning EP, Tardiff JC, Schwartz SD. Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT. Journal of Molecular Biology. 421: 54-66. PMID 22579624 DOI: 10.1016/J.Jmb.2012.05.008 |
0.599 |
|
| 2012 |
Manning EP, Guinto PJ, Tardiff JC. Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: an integrative in silico/in vitro approach. The Journal of Biological Chemistry. 287: 14515-23. PMID 22334656 DOI: 10.1074/Jbc.M111.257436 |
0.813 |
|
| 2012 |
Michael JJ, Mamidi R, Gollapudi S, Tal L, Tardiff J, Chandra M. D230N Mutation in Tropomyosin and R92L Mutation in Cardiac Troponin T have Strikingly Different Impact on Calcium-Regulated Activation of Cardiac Myofilaments Biophysical Journal. 102: 358a. DOI: 10.1016/J.Bpj.2011.11.1956 |
0.587 |
|
| 2012 |
Tal L, Jimenez J, Tardiff JC. DCM-Linked D230N Tropomyosin Mutation Results in Early Dilatation and Systolic Dysfunction in Mice Biophysical Journal. 102: 356a. DOI: 10.1016/J.Bpj.2011.11.1945 |
0.609 |
|
| 2011 |
Manning EP, Tardiff JC, Schwartz SD. A model of calcium activation of the cardiac thin filament. Biochemistry. 50: 7405-13. PMID 21797264 DOI: 10.1021/Bi200506K |
0.479 |
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| 2011 |
Tardiff JC. Thin filament mutations: developing an integrative approach to a complex disorder. Circulation Research. 108: 765-82. PMID 21415410 DOI: 10.1161/Circresaha.110.224170 |
0.534 |
|
| 2011 |
Jimenez J, Tardiff JC. Abnormal heart rate regulation in murine hearts with familial hypertrophic cardiomyopathy-related cardiac troponin T mutations. American Journal of Physiology. Heart and Circulatory Physiology. 300: H627-35. PMID 21131475 DOI: 10.1152/Ajpheart.00247.2010 |
0.495 |
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| 2011 |
Ford SJ, Mamidi R, Jimenez JJ, Tardiff JC, Chandra M. Effects of R92 Mutations on Cardiac Contractile Function are Influenced by Changes in Myosin Heavy Chain Isoform Biophysical Journal. 100: 127a. DOI: 10.1016/J.Bpj.2010.12.898 |
0.512 |
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| 2011 |
Chen-Izu Y, Banyasz T, Khabbaz S, Edelmann S, Payne C, Tardiff JC, Izu LT. Increased Myofilament Ca2+ Sensitivity Decreases Sarcomere Length and Increases Spark-Spark Interactions Biophysical Journal. 100: 560a. DOI: 10.1016/J.Bpj.2010.12.3253 |
0.398 |
|
| 2011 |
Tal L, Moore RK, Dowell-Martino C, Tardiff JC. Pathophysiologic Changes Induced by Mutations in the TNT1 Domain of cTnT that Cause FHC Biophysical Journal. 100: 452a. DOI: 10.1016/J.Bpj.2010.12.2665 |
0.609 |
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| 2011 |
Manning EP, Tardiff JC, Schwartz SD. Computational Modeling of Cardiac Troponin Dynamics: Elucidating a Regulatory Mechanism for Calcium Activation of the Thin Filament Biophysical Journal. 100: 225a. DOI: 10.1016/J.Bpj.2010.12.1440 |
0.413 |
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| 2010 |
Tardiff JC. Tropomyosin and dilated cardiomyopathy: revenge of the actinomyosin "gatekeeper". Journal of the American College of Cardiology. 55: 330-2. PMID 20117438 DOI: 10.1016/J.Jacc.2009.11.018 |
0.497 |
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| 2010 |
Rice R, Guinto P, Dowell-Martino C, He H, Hoyer K, Krenz M, Robbins J, Ingwall JS, Tardiff JC. Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts. Journal of Molecular and Cellular Cardiology. 48: 979-88. PMID 20004663 DOI: 10.1016/J.Yjmcc.2009.11.018 |
0.824 |
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| 2010 |
Moore RK, Guinto PJ, Wilson J, Gerfen G, Tardiff JC. Structural and Functional Characterization of the TNT1 Domain of Cardiac Troponin T Biophysical Journal. 98: 358a. DOI: 10.1016/J.Bpj.2009.12.1934 |
0.795 |
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| 2010 |
Moore RK, Guinto PJ, Dowell-Martino C, Tardiff JC. Functional and Structural Changes Induced By cTNT-Related FHC Mutations in TNT1 Alter Actomyosin Binding Interactions Biophysical Journal. 98: 6a. DOI: 10.1016/J.Bpj.2009.12.038 |
0.838 |
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| 2009 |
Guinto PJ, Haim TE, Dowell-Martino CC, Sibinga N, Tardiff JC. Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models. American Journal of Physiology. Heart and Circulatory Physiology. 297: H614-26. PMID 19502551 DOI: 10.1152/Ajpheart.01143.2008 |
0.826 |
|
| 2009 |
Moore RK, Wilson J, Guinto P, Riegelhaupt M, Gerfen G, Tardiff J. Structural and Functional Characterization of cTnT in Familial Hypertrophic Cardiomyopathy Biophysical Journal. 96: 499a. DOI: 10.1016/J.Bpj.2008.12.2576 |
0.828 |
|
| 2009 |
Guinto PJ, Manning EP, Moore RK, Schwartz SD, Tardiff JC. Structural and Functional Characterization of Cardiac Troponin T Mutations in the TNT1 Domain That Cause Familial Hypertrophic Cardiomyopathy Biophysical Journal. 96: 499a. DOI: 10.1016/J.Bpj.2008.12.2575 |
0.842 |
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| 2007 |
Guinto PJ, Manning EP, Schwartz SD, Tardiff JC. Computational Characterization of Mutations in Cardiac Troponin T Known to Cause Familial Hypertrophic Cardiomyopathy. Journal of Theoretical & Computational Chemistry. 6: 413. PMID 26500385 DOI: 10.1142/S0219633607003271 |
0.835 |
|
| 2007 |
He H, Javadpour MM, Latif F, Tardiff JC, Ingwall JS. R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts. Biophysical Journal. 93: 1834-44. PMID 17526570 DOI: 10.1529/Biophysj.107.107557 |
0.526 |
|
| 2007 |
Haim TE, Dowell C, Diamanti T, Scheuer J, Tardiff JC. Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics. Journal of Molecular and Cellular Cardiology. 42: 1098-110. PMID 17490679 DOI: 10.1016/J.Yjmcc.2007.03.906 |
0.537 |
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| 2006 |
Tardiff JC. Cardiac hypertrophy: stressing out the heart. The Journal of Clinical Investigation. 116: 1467-70. PMID 16741569 DOI: 10.1172/Jci28884 |
0.364 |
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| 2005 |
Tardiff JC. Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes. Heart Failure Reviews. 10: 237-48. PMID 16416046 DOI: 10.1007/S10741-005-5253-5 |
0.519 |
|
| 2005 |
Ertz-Berger BR, He H, Dowell C, Factor SM, Haim TE, Nunez S, Schwartz SD, Ingwall JS, Tardiff JC. Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 18219-24. PMID 16326803 DOI: 10.1073/Pnas.0509181102 |
0.639 |
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| 2005 |
Chandra M, Tschirgi ML, Tardiff JC. Increase in tension-dependent ATP consumption induced by cardiac troponin T mutation. American Journal of Physiology. Heart and Circulatory Physiology. 289: H2112-9. PMID 15994854 DOI: 10.1152/Ajpheart.00571.2005 |
0.502 |
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| 2004 |
Tardiff JC. Myosin at the heart of the problem. The New England Journal of Medicine. 351: 424-6. PMID 15282349 DOI: 10.1056/Nejmp048142 |
0.335 |
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| 2003 |
Javadpour MM, Tardiff JC, Pinz I, Ingwall JS. Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T. The Journal of Clinical Investigation. 112: 768-75. PMID 12952925 DOI: 10.1172/Jci15967 |
0.577 |
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| 2001 |
Montgomery DE, Tardiff JC, Chandra M. Cardiac troponin T mutations: Correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice Journal of Physiology. 536: 583-592. PMID 11600691 DOI: 10.1111/J.1469-7793.2001.0583C.Xd |
0.525 |
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| 2001 |
Chandra M, Rundell VLM, Tardiff JC, Leinwand LA, De Tombe PP, Solaro RJ. Ca2+ activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin t American Journal of Physiology - Heart and Circulatory Physiology. 280: H705-H713. PMID 11158969 DOI: 10.1152/Ajpheart.2001.280.2.H705 |
0.367 |
|
| 2000 |
Tardiff JC, Hewett TE, Factor SM, Vikstrom KL, Robbins J, Leinwand LA. Expression of the β (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects American Journal of Physiology - Heart and Circulatory Physiology. 278. PMID 10666070 DOI: 10.1152/Ajpheart.2000.278.2.H412 |
0.398 |
|
| 1999 |
Tardiff JC, Hewett TE, Palmer BM, Olsson C, Factor SM, Moore RL, Robbins J, Leinwand LA. Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 104: 469-81. PMID 10449439 DOI: 10.1172/Jci6067 |
0.541 |
|
| 1998 |
Tardiff JC, Factor SM, Tompkins BD, Hewett TE, Palmer BM, Moore RL, Schwartz S, Robbins J, Leinwand LA. A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. The Journal of Clinical Investigation. 101: 2800-11. PMID 9637714 DOI: 10.1172/Jci2389 |
0.535 |
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