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Kathryn M. Ferguson - Publications

Affiliations: 
Biochemistry and Molecular Biophysics University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry, Molecular Biology
Website:
http://www.med.upenn.edu/apps/faculty/index.php/g20/p12430
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Hu C, Leche CA, Kiyatkin A, Yu Z, Stayrook SE, Ferguson KM, Lemmon MA. Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. Nature. 602: 518-522. PMID 35140400 DOI: 10.1038/s41586-021-04393-3  0.401
2020 Ferguson KM, Hu C, Lemmon MA. Insulin and EGF receptor family members share parallel activation mechanisms. Protein Science : a Publication of the Protein Society. PMID 32297376 DOI: 10.1002/Pro.3871  0.547
2018 Emptage RP, Lemmon MA, Ferguson KM, Marmorstein R. Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain. Structure (London, England : 1993). 26: 1137-1143.e3. PMID 30099988 DOI: 10.1016/J.Str.2018.05.008  0.683
2017 Bagchi A, Haidar JN, Eastman SW, Vieth M, Topper M, Iacolina MD, Walker JM, Forest A, Shen Y, Novosiadly RD, Ferguson KM. Molecular basis for necitumumab inhibition of EGFR variants associated with acquired cetuximab resistance. Molecular Cancer Therapeutics. PMID 29158469 DOI: 10.1158/1535-7163.Mct-17-0575  0.772
2017 Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell. PMID 28988771 DOI: 10.1016/J.Cell.2017.09.017  0.497
2017 Emptage RP, Schoenberger MJ, Ferguson KM, Marmorstein R. Intramolecular autoinhibition of Checkpoint Kinase 1 is mediated by conserved basic motifs of the C-terminal Kinase Associated-1 domain. The Journal of Biological Chemistry. PMID 28972186 DOI: 10.1074/Jbc.M117.811265  0.647
2017 Moore JO, Lemmon MA, Ferguson KM. Dimerization of Tie2 mediated by its membrane-proximal FNIII domains. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396397 DOI: 10.1073/Pnas.1617800114  0.56
2016 Emptage RP, Lemmon MA, Ferguson KM. Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase. The Biochemical Journal. PMID 27879374 DOI: 10.1042/Bcj20160792  0.54
2015 Moravcevic K, Alvarado D, Schmitz KR, Kenniston JA, Mendrola JM, Ferguson KM, Lemmon MA. Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site. Structure (London, England : 1993). 23: 352-63. PMID 25620000 DOI: 10.1016/J.Str.2014.12.009  0.738
2014 Bessman NJ, Bagchi A, Ferguson KM, Lemmon MA. Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor. Cell Reports. 9: 1306-17. PMID 25453753 DOI: 10.1016/J.Celrep.2014.10.010  0.788
2014 Huoh YS, Ferguson KM. The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities. Biochemistry. 53: 4946-55. PMID 25027698 DOI: 10.1021/Bi5005156  0.799
2014 Lemmon MA, Schlessinger J, Ferguson KM. The EGFR family: not so prototypical receptor tyrosine kinases. Cold Spring Harbor Perspectives in Biology. 6: a020768. PMID 24691965 DOI: 10.1101/Cshperspect.A020768  0.529
2014 Bagchi A, Bessman NJ, Wu NZ, Raines L, Kan Z, Hu W, Englander SW, Leahy DJ, Lemmon MA, Ferguson KM. Allosteric Regulation of the Epidermal Growth Factor Receptor Biophysical Journal. 106: 105a. DOI: 10.1016/J.Bpj.2013.11.650  0.786
2013 Schmitz KR, Bagchi A, Roovers RC, van Bergen en Henegouwen PM, Ferguson KM. Structural evaluation of EGFR inhibition mechanisms for nanobodies/VHH domains. Structure (London, England : 1993). 21: 1214-24. PMID 23791944 DOI: 10.1016/J.Str.2013.05.008  0.78
2013 Huoh Y, Ferguson KM. The Molecular Basis of Substrate Recognition by the E3 Ubiquitin Ligase Pellino Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.3384  0.802
2012 Wood CS, Hung CS, Huoh YS, Mousley CJ, Stefan CJ, Bankaitis V, Ferguson KM, Burd CG. Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase. Molecular Biology of the Cell. 23: 2527-36. PMID 22553352 DOI: 10.1091/Mbc.E12-01-0077  0.759
2012 Ferguson KM. Discoidin discoveries. Structure (London, England : 1993). 20: 568-70. PMID 22483103 DOI: 10.1016/j.str.2012.03.003  0.348
2011 Roovers RC, Vosjan MJ, Laeremans T, el Khoulati R, de Bruin RC, Ferguson KM, Verkleij AJ, van Dongen GA, van Bergen en Henegouwen PM. A biparatopic anti-EGFR nanobody efficiently inhibits solid tumour growth. International Journal of Cancer. 129: 2013-24. PMID 21520037 DOI: 10.1002/Ijc.26145  0.471
2009 Wood CS, Schmitz KR, Bessman NJ, Setty TG, Ferguson KM, Burd CG. PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking. The Journal of Cell Biology. 187: 967-75. PMID 20026658 DOI: 10.1083/Jcb.200909063  0.753
2009 Schmitz KR, Ferguson KM. Interaction of antibodies with ErbB receptor extracellular regions. Experimental Cell Research. 315: 659-70. PMID 18992239 DOI: 10.1016/J.Yexcr.2008.10.008  0.747
2008 Lin CC, Huoh YS, Schmitz KR, Jensen LE, Ferguson KM. Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Structure (London, England : 1993). 16: 1806-16. PMID 19081057 DOI: 10.1016/J.Str.2008.09.011  0.768
2008 Ferguson KM. Structure-based view of epidermal growth factor receptor regulation. Annual Review of Biophysics. 37: 353-73. PMID 18573086 DOI: 10.1146/Annurev.Biophys.37.032807.125829  0.551
2008 Schmitz KR, Liu J, Li S, Setty TG, Wood CS, Burd CG, Ferguson KM. Golgi localization of glycosyltransferases requires a Vps74p oligomer. Developmental Cell. 14: 523-34. PMID 18410729 DOI: 10.1016/J.Devcel.2008.02.016  0.723
2008 Schmiedel J, Blaukat A, Li S, Knöchel T, Ferguson KM. Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell. 13: 365-73. PMID 18394559 DOI: 10.1016/J.Ccr.2008.02.019  0.608
2008 Li S, Kussie P, Ferguson KM. Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8. Structure (London, England : 1993). 16: 216-27. PMID 18275813 DOI: 10.1016/J.Str.2007.11.009  0.479
2007 Lemmon MA, Ferguson KM. A new twist in the transmembrane signaling tool-kit. Cell. 130: 213-5. PMID 17662934 DOI: 10.1016/J.Cell.2007.07.006  0.465
2005 Bouyain S, Longo PA, Li S, Ferguson KM, Leahy DJ. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. Proceedings of the National Academy of Sciences of the United States of America. 102: 15024-9. PMID 16203964 DOI: 10.1073/Pnas.0507591102  0.541
2005 Dawson JP, Berger MB, Lin CC, Schlessinger J, Lemmon MA, Ferguson KM. Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface. Molecular and Cellular Biology. 25: 7734-42. PMID 16107719 DOI: 10.1128/Mcb.25.17.7734-7742.2005  0.535
2005 Li S, Schmitz KR, Jeffrey PD, Wiltzius JJ, Kussie P, Ferguson KM. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell. 7: 301-11. PMID 15837620 DOI: 10.1016/J.Ccr.2005.03.003  0.796
2004 Ferguson KM. Active and inactive conformations of the epidermal growth factor receptor Biochemical Society Transactions. 32: 742-745. PMID 15494003 DOI: 10.1042/Bst0320742  0.531
2003 Burgess AW, Cho HS, Eigenbrot C, Ferguson KM, Garrett TP, Leahy DJ, Lemmon MA, Sliwkowski MX, Ward CW, Yokoyama S. An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Molecular Cell. 12: 541-52. PMID 14527402 DOI: 10.1016/S1097-2765(03)00350-2  0.511
2003 Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 11: 507-17. PMID 12620237 DOI: 10.1016/S1097-2765(03)00047-9  0.507
2002 Lemmon MA, Ferguson KM, Abrams CS. Pleckstrin homology domains and the cytoskeleton. Febs Letters. 513: 71-6. PMID 11911883 DOI: 10.1016/S0014-5793(01)03243-4  0.52
2001 Lemmon MA, Ferguson KM. Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides Biochemical Society Transactions. 29: 377-384. PMID 11497993 DOI: 10.1042/Bst0290377  0.502
2000 Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Molecular Cell. 6: 373-84. PMID 10983984 DOI: 10.1016/S1097-2765(00)00037-X  0.473
2000 Ferguson KM, Darling PJ, Mohan MJ, Macatee TL, Lemmon MA. Extracellular domains drive homo- but not hetero-dimerization of erbB receptors. The Embo Journal. 19: 4632-43. PMID 10970856 DOI: 10.1093/Emboj/19.17.4632  0.53
2000 Lemmon MA, Ferguson KM. Signal-dependent membrane targeting by pleckstrin homology (PH) domains Biochemical Journal. 350: 1-18. PMID 10926821 DOI: 10.1042/0264-6021:3500001  0.383
2000 LEMMON MA, FERGUSON KM. Signal-dependent membrane targeting by pleckstrin homology (PH) domains Biochemical Journal. 350: 1-18. DOI: 10.1042/Bj3500001  0.482
1998 Isakoff SJ, Cardozo T, Andreev J, Li Z, Ferguson KM, Abagyan R, Lemmon MA, Aronheim A, Skolnik EY. Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. The Embo Journal. 17: 5374-87. PMID 9736615 DOI: 10.1093/Emboj/17.18.5374  0.478
1998 Lemmon MA, Ferguson KM. Pleckstrin homology domains. Current Topics in Microbiology and Immunology. 228: 39-74. PMID 9401202 DOI: 10.1007/978-3-642-80481-6_3  0.482
1996 Lemmon MA, Ferguson KM, Schlessinger J. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell. 85: 621-4. PMID 8646770 DOI: 10.1016/S0092-8674(00)81022-3  0.506
1995 Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell. 83: 1037-46. PMID 8521504 DOI: 10.1016/0092-8674(95)90219-8  0.66
1995 Ferguson KM, Lemmon MA, Sigler PB, Schlessinger J. Scratching the surface with the PH domain. Nature Structural Biology. 2: 715-8. PMID 7552736 DOI: 10.1038/Nsb0995-715  0.613
1995 Lemmon MA, Ferguson KM, O'Brien R, Sigler PB, Schlessinger J. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proceedings of the National Academy of Sciences of the United States of America. 92: 10472-6. PMID 7479822 DOI: 10.1073/Pnas.92.23.10472  0.668
1994 Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin. Cell. 79: 199-209. PMID 7954789 DOI: 10.1016/0092-8674(94)90190-2  0.608
1986 Ferguson KM, Higashijima T, Smigel MD, Gilman AG. The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins Journal of Biological Chemistry. 261: 7393-7399. PMID 3086311  0.303
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