Michele Vendruscolo, Professor - Publications

Affiliations: 
Chemistry University of Cambridge, Cambridge, England, United Kingdom 
Area:
Protein biophysics

233 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Delivoria DC, Chia S, Habchi J, Perni M, Matis I, Papaevgeniou N, Reczko M, Chondrogianni N, Dobson CM, Vendruscolo M, Skretas G. Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation. Science Advances. 5: eaax5108. PMID 31663025 DOI: 10.1126/sciadv.aax5108  0.84
2019 Ruggeri FS, Šneideris T, Chia S, Vendruscolo M, Knowles TPJ. Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy. Journal of Visualized Experiments : Jove. PMID 31566623 DOI: 10.3791/60108  0.8
2019 Liao YC, Fernandopulle MS, Wang G, Choi H, Hao L, Drerup CM, Patel R, Qamar S, Nixon-Abell J, Shen Y, Meadows W, Vendruscolo M, Knowles TPJ, Nelson M, Czekalska MA, et al. RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether. Cell. 179: 147-164.e20. PMID 31539493 DOI: 10.1016/j.cell.2019.08.050  0.8
2019 Wang X, Kirkpatrick JP, Launay HMM, de Simone A, Häussinger D, Dobson CM, Vendruscolo M, Cabrita LD, Waudby CA, Christodoulou J. Probing the dynamic stalk region of the ribosome using solution NMR. Scientific Reports. 9: 13528. PMID 31537834 DOI: 10.1038/s41598-019-49190-1  0.84
2019 Lindstedt PR, Aprile FA, Matos MJ, Perni M, Bertoldo JB, Bernardim B, Peter Q, Jiménez-Osés G, Knowles TPJ, Dobson CM, Corzana F, Vendruscolo M, Bernardes GJL. Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification. Acs Central Science. 5: 1417-1424. PMID 31482124 DOI: 10.1021/acscentsci.9b00467  0.84
2019 Löhr T, Camilloni C, Bonomi M, Vendruscolo M. A Practical Guide to the Simultaneous Determination of Protein Structure and Dynamics Using Metainference. Methods in Molecular Biology (Clifton, N.J.). 2022: 313-340. PMID 31396909 DOI: 10.1007/978-1-4939-9608-7_13  1
2019 Zhao L, Vecchi G, Vendruscolo M, Körner R, Hayer-Hartl M, Hartl FU. The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli. Cell Reports. 28: 1335-1345.e6. PMID 31365874 DOI: 10.1016/j.celrep.2019.06.081  0.32
2019 De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, et al. Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression. Acta Neuropathologica Communications. 7: 120. PMID 31349874 DOI: 10.1186/s40478-019-0777-4  0.8
2019 Mannini B, Vecchi G, Labrador-Garrido A, Fabre B, Fani G, Munoz Franco J, Lilley KS, Pozo D, Vendruscolo M, Chiti F, Dobson CM, Roodveldt C. Differential interactome and innate immune response activation of two structurally distinct misfolded protein oligomers. Acs Chemical Neuroscience. PMID 31313906 DOI: 10.1021/acschemneuro.9b00088  0.84
2019 Laine RF, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EAA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF. Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans. Acs Chemical Biology. PMID 31246415 DOI: 10.1021/acschembio.9b00354  0.84
2019 Sinnige T, Ciryam P, Casford S, Dobson CM, de Bono M, Vendruscolo M. Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response. Plos One. 14: e0217746. PMID 31150491 DOI: 10.1371/journal.pone.0217746  0.84
2019 Eshun-Wilson L, Zhang R, Portran D, Nachury MV, Toso DB, Löhr T, Vendruscolo M, Bonomi M, Fraser JS, Nogales E. Effects of α-tubulin acetylation on microtubule structure and stability. Proceedings of the National Academy of Sciences of the United States of America. PMID 31072936 DOI: 10.1073/pnas.1900441116  0.6
2019 Cascella R, Perni M, Chen SW, Fusco G, Cecchi C, Vendruscolo M, Chiti F, Dobson CM, De Simone A. Probing the origin of the toxicity of oligomeric aggregates of α-synuclein with antibodies. Acs Chemical Biology. PMID 31050886 DOI: 10.1021/acschembio.9b00312  0.84
2019 Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P. Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates. Science Advances. 5: eaau3112. PMID 31001578 DOI: 10.1126/sciadv.aau3112  0.84
2019 Ahmed N, Sormanni P, Ciryam P, Vendruscolo M, Dobson CM, O'Brien EP. Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming. Scientific Reports. 9: 6256. PMID 31000737 DOI: 10.1038/s41598-019-42348-x  0.84
2019 Kukic P, Lo Piccolo GM, Nogueira MO, Svergun DI, Vendruscolo M, Felli IC, Pierattelli R. The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions. Scientific Reports. 9: 5822. PMID 30967564 DOI: 10.1038/s41598-019-41925-4  0.68
2019 Yerbury JJ, Ooi L, Blair IP, Ciryam P, Dobson CM, Vendruscolo M. The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS. Neuroscience Letters. PMID 30953736 DOI: 10.1016/j.neulet.2019.04.001  0.84
2019 De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, ... Vendruscolo M, et al. Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms. Nature Communications. 10: 1541. PMID 30948723 DOI: 10.1038/s41467-019-09477-3  0.84
2019 Dobson CM, Knowles TPJ, Vendruscolo M. The Amyloid Phenomenon and Its Significance in Biology and Medicine. Cold Spring Harbor Perspectives in Biology. PMID 30936117 DOI: 10.1101/cshperspect.a033878  0.84
2019 Sanagavarapu K, Nüske E, Nasir I, Meisl G, Immink JN, Sormanni P, Vendruscolo M, Knowles TPJ, Malmendal A, Cabaleiro-Lago C, Linse S. A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli. Scientific Reports. 9: 3680. PMID 30842594 DOI: 10.1038/s41598-019-39216-z  0.8
2019 Sormanni P, Vendruscolo M. Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis. Cold Spring Harbor Perspectives in Biology. PMID 30833455 DOI: 10.1101/cshperspect.a033845  0.56
2019 Ruggeri FS, Šneideris T, Vendruscolo M, Knowles TPJ. Atomic force microscopy for single molecule characterisation of protein aggregation. Archives of Biochemistry and Biophysics. PMID 30742801 DOI: 10.1016/j.abb.2019.02.001  0.8
2019 Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, ... ... Vendruscolo M, et al. Trodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nature Communications. 10: 225. PMID 30644384 DOI: 10.1038/s41467-018-07699-5  0.84
2019 Ahn M, Lee BI, Chia S, Habchi J, Kumita JR, Vendruscolo M, Dobson CM, Park CB. Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation. Chemical Communications (Cambridge, England). PMID 30632567 DOI: 10.1039/c8cc09288e  0.84
2019 Fu H, Possenti A, Freer R, Nakano Y, Villegas NCH, Tang M, Cauhy PVM, Lassus BA, Chen S, Fowler SL, Figueroa HY, Huey ED, Johnson GVW, Vendruscolo M, Duff KE. A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology. Nature Neuroscience. 22: 47-56. PMID 30559469 DOI: 10.1038/s41593-018-0298-7  0.44
2018 Perni M, Casford S, Aprile FA, Nollen EA, Knowles TPJ, Vendruscolo M, Dobson CM. Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform. Journal of Visualized Experiments : Jove. PMID 30582580 DOI: 10.3791/58643  0.84
2018 Marinho da Silva Neto A, Silva SR, Vendruscolo M, Camilloni C, Montalvao RW. A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone. Proteins. PMID 30582223 DOI: 10.1002/prot.25652  1
2018 Wolf Pérez AM, Sormanni P, Andersen JS, Sakhnini LI, Rodriguez-Leon I, Bjelke JR, Gajhede AJ, De Maria L, Otzen DE, Vendruscolo M, Lorenzen N. In vitro and in silico assessment of the developability of a designed monoclonal antibody library. Mabs. PMID 30523762 DOI: 10.1080/19420862.2018.1556082  0.56
2018 Bonomi M, Vendruscolo M. Determination of protein structural ensembles using cryo-electron microscopy. Current Opinion in Structural Biology. 56: 37-45. PMID 30502729 DOI: 10.1016/j.sbi.2018.10.006  0.6
2018 Rangan R, Bonomi M, Heller GT, Cesari A, Bussi G, Vendruscolo M. Determination of Structural Ensembles of Proteins: Restraining vs Reweighting. Journal of Chemical Theory and Computation. PMID 30428663 DOI: 10.1021/acs.jctc.8b00738  0.6
2018 Bonomi M, Hanot S, Greenberg CH, Sali A, Nilges M, Vendruscolo M, Pellarin R. Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling. Structure (London, England : 1993). PMID 30393052 DOI: 10.1016/j.str.2018.09.011  0.6
2018 Sormanni P, Aprile FA, Vendruscolo M. Third generation antibody discovery methods: in silico rational design. Chemical Society Reviews. PMID 30298157 DOI: 10.1039/c8cs00523k  0.68
2018 Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. SAR by kinetics for drug discovery in protein misfolding diseases. Proceedings of the National Academy of Sciences of the United States of America. PMID 30257937 DOI: 10.1073/pnas.1807884115  0.84
2018 Ruggeri FS, Charmet J, Kartanas T, Peter Q, Chia S, Habchi J, Dobson CM, Vendruscolo M, Knowles TPJ. Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity. Nature Communications. 9: 3890. PMID 30250131 DOI: 10.1038/s41467-018-06345-4  0.84
2018 Waudby CA, Wlodarski T, Karyadi ME, Cassaignau AME, Chan SHS, Wentink AS, Schmidt-Engler JM, Camilloni C, Vendruscolo M, Cabrita LD, Christodoulou J. Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30201720 DOI: 10.1073/pnas.1716252115  1
2018 Aprile FA, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Scientific Reports. 8: 11848. PMID 30068912 DOI: 10.1038/s41598-018-29893-7  0.68
2018 Tomba G, Camilloni C, Vendruscolo M. Determination of the conformational states of strychnine using NMR residual dipolar couplings in a tensor-free approach. Methods (San Diego, Calif.). PMID 30036639 DOI: 10.1016/j.ymeth.2018.07.005  1
2018 Capitini C, Patel JR, Natalello A, D'Andrea C, Relini A, Jarvis JA, Birolo L, Peduzzo A, Vendruscolo M, Matteini P, Dobson CM, De Simone A, Chiti F. Structural differences between toxic and nontoxic HypF-N oligomers. Chemical Communications (Cambridge, England). PMID 30020284 DOI: 10.1039/c8cc03446j  0.84
2018 Papaleo E, Camilloni C, Teilum K, Vendruscolo M, Lindorff-Larsen K. Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs. Peerj. 6: e5125. PMID 30013831 DOI: 10.7717/peerj.5125  1
2018 Mannini B, Habchi J, Chia SKR, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M. Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of zinc ions. Acs Chemical Neuroscience. PMID 29986583 DOI: 10.1021/acschemneuro.8b00141  0.84
2018 Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, ... ... Vendruscolo M, et al. Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. Acs Chemical Biology. PMID 29953201 DOI: 10.1021/acschembio.8b00466  0.84
2018 Vahidi S, Ripstein ZA, Bonomi M, Yuwen T, Mabanglo MF, Juravsky JB, Rizzolo K, Velyvis A, Houry WA, Vendruscolo M, Rubinstein JL, Kay LE. Reversible inhibition of the ClpP protease via an N-terminal conformational switch. Proceedings of the National Academy of Sciences of the United States of America. PMID 29941580 DOI: 10.1073/pnas.1805125115  0.6
2018 Possenti A, Vendruscolo M, Camilloni C, Tiana G. A method for partitioning the information contained in a protein sequence between its structure and function. Proteins. PMID 29790601 DOI: 10.1002/prot.25527  1
2018 Wright MA, Aprile FA, Bellaiche MM, Michaels TCT, Müller T, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ. Cooperative assembly of Hsp70 subdomain clusters. Biochemistry. PMID 29763298 DOI: 10.1021/acs.biochem.8b00151  0.84
2018 Bongiovanni MN, Aprile FA, Sormanni P, Vendruscolo M. A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells. International Journal of Molecular Sciences. 19. PMID 29757200 DOI: 10.3390/ijms19051443  0.68
2018 Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nature Chemistry. PMID 29736006 DOI: 10.1038/s41557-018-0031-x  0.84
2018 Qamar S, Wang G, Randle SJ, Ruggeri FS, Varela JA, Lin JQ, Phillips EC, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov VJ, Tartaglia GG, Farrer LA, ... ... Vendruscolo M, et al. FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions. Cell. 173: 720-734.e15. PMID 29677515 DOI: 10.1016/j.cell.2018.03.056  0.52
2018 Liberis E, Velickovic P, Sormanni P, Vendruscolo M, Liò P. Parapred: Antibody Paratope Prediction using Convolutional and Recurrent Neural Networks. Bioinformatics (Oxford, England). PMID 29672675 DOI: 10.1093/bioinformatics/bty305  0.56
2018 Bonomi M, Pellarin R, Vendruscolo M. Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy. Biophysical Journal. 114: 1604-1613. PMID 29642030 DOI: 10.1016/j.bpj.2018.02.028  0.6
2018 El Turk F, De Genst E, Guilliams T, Fauvet B, Hejjaoui M, Di Trani J, Chiki A, Mittermaier A, Vendruscolo M, Lashuel HA, Dobson CM. Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding. Protein Science : a Publication of the Protein Society. PMID 29603451 DOI: 10.1002/pro.3412  0.84
2018 Fusco G, Sanz-Hernandez M, Ruggeri FS, Vendruscolo M, Dobson CM, De Simone A. Molecular determinants of the interaction of EGCG with ordered and disordered proteins. Biopolymers. e23117. PMID 29603125 DOI: 10.1002/bip.23117  0.84
2018 Heller GT, Bonomi M, Vendruscolo M. A structural ensemble modulation mechanism of small molecule binding to disordered proteins. Journal of Molecular Biology. PMID 29596915 DOI: 10.1016/j.jmb.2018.03.015  0.6
2018 Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S. Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide. Nature Chemistry. PMID 29581486 DOI: 10.1038/s41557-018-0023-x  0.84
2018 Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ. Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation. Annual Review of Physical Chemistry. PMID 29490200 DOI: 10.1146/annurev-physchem-050317-021322  0.84
2018 Perni M, Challa PK, Kirkegaard JB, Limbocker R, Koopman M, Hardenberg MC, Sormanni P, Müller T, Saar KL, Roode LWY, Habchi J, Vecchi G, Fernando NW, Casford S, Nollen EAA, ... Vendruscolo M, et al. Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery. Journal of Neuroscience Methods. PMID 29452179 DOI: 10.1016/j.jneumeth.2018.02.005  0.84
2017 Fusco G, Chen SW, Williamson PTF, Cascella R, Perni M, Jarvis JA, Cecchi C, Vendruscolo M, Chiti F, Cremades N, Ying L, Dobson CM, De Simone A. Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers. Science (New York, N.Y.). 358: 1440-1443. PMID 29242346 DOI: 10.1126/science.aan6160  0.84
2017 Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ. Scaling behaviour and rate-determining steps in filamentous self-assembly. Chemical Science. 8: 7087-7097. PMID 29147538 DOI: 10.1039/c7sc01965c  0.84
2017 Piovesan D, Tabaro F, Paladin L, Necci M, Micetic I, Camilloni C, Davey N, Dosztányi Z, Mészáros B, Monzon AM, Parisi G, Schad E, Sormanni P, Tompa P, Vendruscolo M, et al. MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins. Nucleic Acids Research. PMID 29136219 DOI: 10.1093/nar/gkx1071  1
2017 Perni M, Aprile FA, Casford S, Mannini B, Sormanni P, Dobson CM, Vendruscolo M. Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles. Scientific Reports. 7: 15045. PMID 29118344 DOI: 10.1038/s41598-017-13755-9  0.84
2017 Martínez-Sáez N, Sun S, Oldrini D, Sormanni P, Boutureira O, Carboni F, Compañón I, Deery M, Vendruscolo M, Corzana F, Adamo R, Bernardes GJL. Oxetane grafts site-selectively installed on native disulfides enhance protein stability and activity in vivo. Angewandte Chemie (International Ed. in English). PMID 28968001 DOI: 10.1002/anie.201708847  0.56
2017 Aprile FA, Källstig E, Limorenko G, Vendruscolo M, Ron D, Hansen C. The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation. Scientific Reports. 7: 9039. PMID 28831037 DOI: 10.1038/s41598-017-08324-z  0.68
2017 Sormanni P, Amery L, Ekizoglou S, Vendruscolo M, Popovic B. Rapid and accurate in silico solubility screening of a monoclonal antibody library. Scientific Reports. 7: 8200. PMID 28811609 DOI: 10.1038/s41598-017-07800-w  0.56
2017 Heller GT, Aprile FA, Bonomi M, Camilloni C, De Simone A, Vendruscolo M. Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide. Journal of Molecular Biology. PMID 28743590 DOI: 10.1016/j.jmb.2017.07.016  1
2017 Chia S, Flagmeier P, Habchi J, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates. Proceedings of the National Academy of Sciences of the United States of America. PMID 28698377 DOI: 10.1073/pnas.1700239114  0.84
2017 Aprile FA, Sormanni P, Perni M, Arosio P, Linse S, Knowles TPJ, Dobson CM, Vendruscolo M. Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method. Science Advances. 3: e1700488. PMID 28691099 DOI: 10.1126/sciadv.1700488  0.84
2017 Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, et al. Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species. Bmc Biology. 15: 57. PMID 28673288 DOI: 10.1186/s12915-017-0390-6  0.84
2017 Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M. Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652376 DOI: 10.1073/pnas.1618417114  0.84
2017 Heller GT, Aprile FA, Vendruscolo M. Methods of probing the interactions between small molecules and disordered proteins. Cellular and Molecular Life Sciences : Cmls. PMID 28631009 DOI: 10.1007/s00018-017-2563-4  0.68
2017 Munke A, Persson J, Weiffert T, De Genst E, Meisl G, Arosio P, Carnerup A, Dobson CM, Vendruscolo M, Knowles TPJ, Linse S. Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 28584111 DOI: 10.1073/pnas.1700407114  0.84
2017 Stroobants K, Kumita JR, Harris N, Chirgadze D, Dobson CM, Booth PJ, Vendruscolo M. Amyloid-like fibrils from an α-helical transmembrane protein. Biochemistry. PMID 28493669 DOI: 10.1021/acs.biochem.7b00157  0.84
2017 Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Schierle GSK, Vendruscolo M, Veglia G, Dobson CM, De Simone A. Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein. Nature Communications. 8: 15667. PMID 28492274 DOI: 10.1038/ncomms15667  0.84
2017 Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE. The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage. Elife. 6. PMID 28406400 DOI: 10.7554/eLife.23872  0.68
2017 Kukic P, Pustovalova Y, Camilloni C, Gianni S, Korzhnev DM, Vendruscolo M. Structural characterization of the early events in the nucleation-condensation mechanism in a protein folding process. Journal of the American Chemical Society. PMID 28401755 DOI: 10.1021/jacs.7b01540  1
2017 Hultqvist G, Åberg E, Camilloni C, Sundell GN, Andersson E, Dogan J, Chi CN, Vendruscolo M, Jemth P. Emergence and evolution of an interaction between intrinsically disordered proteins. Elife. 6. PMID 28398197 DOI: 10.7554/eLife.16059  1
2017 Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ. Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396410 DOI: 10.1073/pnas.1613854114  0.84
2017 Yoshimura Y, Holmberg MA, Kukic P, Andersen CB, Mata-Cabana A, Falsone SF, Vendruscolo M, Nollen EA, Mulder FA. MOAG-4 Promotes the Aggregation of α-Synuclein by Competing with Self-Protective Electrostatic Interactions. The Journal of Biological Chemistry. PMID 28336532 DOI: 10.1074/jbc.M116.764886  0.68
2017 Sormanni P, Piovesan D, Heller GT, Bonomi M, Kukic P, Camilloni C, Fuxreiter M, Dosztanyi Z, Pappu RV, Babu MM, Longhi S, Tompa P, Dunker AK, Uversky VN, Tosatto SC, ... Vendruscolo M, et al. Simultaneous quantification of protein order and disorder. Nature Chemical Biology. 13: 339-342. PMID 28328918 DOI: 10.1038/nchembio.2331  1
2017 Sin O, de Jong T, Mata-Cabana A, Kudron M, Zaini MA, Aprile FA, Seinstra RI, Stroo E, Prins RW, Martineau CN, Wang HH, Hogewerf W, Steinhof A, Wanker EE, Vendruscolo M, et al. Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation. Molecular Cell. 65: 1096-1108.e6. PMID 28306505 DOI: 10.1016/j.molcel.2017.02.022  0.68
2017 Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 168: 944. PMID 28235202 DOI: 10.1016/j.cell.2016.12.041  0.84
2017 Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N. Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. Biochemistry. PMID 28230968 DOI: 10.1021/acs.biochem.6b01178  0.84
2017 Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limboker R, Sormanni P, Heller GT, Aprile FA, ... ... Vendruscolo M, et al. A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096355 DOI: 10.1073/pnas.1610586114  0.84
2017 Borkar AN, Vallurupalli P, Camilloni C, Kay LE, Vendruscolo M. Simultaneous NMR characterisation of multiple minima in the free energy landscape of an RNA UUCG tetraloop. Physical Chemistry Chemical Physics : Pccp. PMID 28067358 DOI: 10.1039/c6cp08313g  1
2017 Bonomi M, Heller GT, Camilloni C, Vendruscolo M. Principles of protein structural ensemble determination. Current Opinion in Structural Biology. 42: 106-116. PMID 28063280 DOI: 10.1016/j.sbi.2016.12.004  1
2016 Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ. Networks of Dynamic Allostery Regulate Enzyme Function. Structure (London, England : 1993). PMID 28089447 DOI: 10.1016/j.str.2016.12.003  1
2016 Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M. Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28011763 DOI: 10.1073/pnas.1615613114  0.84
2016 Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C. β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces. Scientific Reports. 6: 36010. PMID 27808107 DOI: 10.1038/srep36010  0.84
2016 Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Kaminski Schierle GS, Vendruscolo M, Veglia G, Dobson CM, De Simone A. Structural basis of synaptic vesicle assembly promoted by α-synuclein. Nature Communications. 7: 12563. PMID 27640673 DOI: 10.1038/ncomms12563  0.84
2016 Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C. Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573854 DOI: 10.1073/pnas.1604645113  0.84
2016 Bonomi M, Camilloni C, Vendruscolo M. Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics. Scientific Reports. 6: 31232. PMID 27561930 DOI: 10.1038/srep31232  1
2016 Freer R, Sormanni P, Vecchi G, Ciryam P, Dobson CM, Vendruscolo M. A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer's disease. Science Advances. 2: e1600947. PMID 27532054 DOI: 10.1126/sciadv.1600947  0.84
2016 Camilloni C, Bonetti D, Morrone A, Giri R, Dobson CM, Brunori M, Gianni S, Vendruscolo M. Towards a structural biology of the hydrophobic effect in protein folding. Scientific Reports. 6: 28285. PMID 27461719 DOI: 10.1038/srep28285  1
2016 Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK, Sparr E, Dobson CM. Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. PMID 27298346 DOI: 10.1073/pnas.1601899113  0.84
2016 Borkar AN, Bardaro MF, Camilloni C, Aprile FA, Varani G, Vendruscolo M. Structure of a low-population binding intermediate in protein-RNA recognition. Proceedings of the National Academy of Sciences of the United States of America. PMID 27286828 DOI: 10.1073/pnas.1521349113  1
2016 Fusco G, De Simone A, Arosio P, Vendruscolo M, Veglia G, Dobson CM. Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity. Scientific Reports. 6: 27125. PMID 27273030 DOI: 10.1038/srep27125  0.84
2016 Camilloni C, Sala BM, Sormanni P, Porcari R, Corazza A, De Rosa M, Zanini S, Barbiroli A, Esposito G, Bolognesi M, Bellotti V, Vendruscolo M, Ricagno S. Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability. Scientific Reports. 6: 25559. PMID 27150430 DOI: 10.1038/srep25559  1
2016 El-Turk F, Newby F, de Genst EJ, Guilliams T, Sprules T, Mittermaier AK, Dobson CM, Vendruscolo M. Structural effects of two camelid nanobodies directed to distinct C-terminal epitopes on α-synuclein. Biochemistry. PMID 27096466 DOI: 10.1021/acs.biochem.6b00149  0.84
2016 Deckert A, Waudby CA, Wlodarski T, Wentink AS, Wang X, Kirkpatrick JP, Paton JF, Camilloni C, Kukic P, Dobson CM, Vendruscolo M, Cabrita LD, Christodoulou J. Structural characterization of the interaction of α-synuclein nascent chains with the ribosomal surface and trigger factor. Proceedings of the National Academy of Sciences of the United States of America. PMID 27092002 DOI: 10.1073/pnas.1519124113  1
2016 Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M. A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071083 DOI: 10.1073/pnas.1516604113  0.84
2016 Arosio P, Michaels TC, Linse S, Månsson C, Emanuelsson C, Presto J, Johansson J, Vendruscolo M, Dobson CM, Knowles TP. Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation. Nature Communications. 7: 10948. PMID 27009901 DOI: 10.1038/ncomms10948  1
2016 Bonetti D, Camilloni C, Visconti L, Longhi S, Brunori M, Vendruscolo M, Gianni S. Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X domain. The Journal of Biological Chemistry. PMID 27002146 DOI: 10.1074/jbc.M116.721126  1
2016 Habchi J, Arosio P, Perni M, Costa AR, Yagi-Utsumi M, Joshi P, Chia S, Cohen SI, Müller MB, Linse S, Nollen EA, Dobson CM, Knowles TP, Vendruscolo M. An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease. Science Advances. 2: e1501244. PMID 26933687 DOI: 10.1126/sciadv.1501244  1
2016 Cabrita LD, Cassaignau AM, Launay HM, Waudby CA, Wlodarski T, Camilloni C, Karyadi ME, Robertson AL, Wang X, Wentink AS, Goodsell LS, Woolhead CA, Vendruscolo M, Dobson CM, Christodoulou J. A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding. Nature Structural & Molecular Biology. PMID 26926436 DOI: 10.1038/nsmb.3182  1
2016 Joshi P, Chia S, Habchi J, Knowles TP, Dobson CM, Vendruscolo M. A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins. Acs Combinatorial Science. PMID 26923286 DOI: 10.1021/acscombsci.5b00129  0.84
2016 Toto A, Camilloni C, Giri R, Brunori M, Vendruscolo M, Gianni S. Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein. Scientific Reports. 6: 21994. PMID 26912067 DOI: 10.1038/srep21994  1
2016 Michaels TC, Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Hamiltonian Dynamics of Protein Filament Formation. Physical Review Letters. 116: 038101. PMID 26849615 DOI: 10.1103/PhysRevLett.116.038101  1
2016 Bonomi M, Camilloni C, Cavalli A, Vendruscolo M. Metainference: A Bayesian inference method for heterogeneous systems. Science Advances. 2: e1501177. PMID 26844300 DOI: 10.1126/sciadv.1501177  1
2016 Meisl G, Kirkegaard JB, Arosio P, Michaels TC, Vendruscolo M, Dobson CM, Linse S, Knowles TP. Molecular mechanisms of protein aggregation from global fitting of kinetic models. Nature Protocols. 11: 252-72. PMID 26741409 DOI: 10.1038/nprot.2016.010  0.84
2015 Arosio P, Müller T, Rajah L, Yates EV, Aprile FA, Zhang Y, Cohen SI, White DA, Herling TW, de Genst EJ, Linse S, Vendruscolo M, Dobson CM, Knowles TP. Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins Under Native Solution Conditions. Acs Nano. PMID 26678709 DOI: 10.1021/acsnano.5b04713  0.84
2015 Camilloni C, Vendruscolo M. Using pseudocontact shifts and residual dipolar couplings as exact NMR restraints for the determination of protein structural ensembles. Biochemistry. PMID 26624789 DOI: 10.1021/acs.biochem.5b01138  1
2015 Kukic P, Lundström P, Camilloni C, Evenäs J, Akke M, Vendruscolo M. Structural insights into the calcium-mediated allosteric transition in the C-terminal domain of calmodulin from NMR measurements. Biochemistry. PMID 26618792 DOI: 10.1021/acs.biochem.5b00961  1
2015 Murakami T, Qamar S, Lin JQ, Schierle GS, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FT, Michel CH, Kronenberg-Versteeg D, Li Y, Yang SP, Wakutani Y, Meadows W, ... ... Vendruscolo M, et al. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function. Neuron. PMID 26526393 DOI: 10.1016/j.neuron.2015.10.030  1
2015 Pickhardt M, Neumann T, Schwizer D, Callaway K, Vendruscolo M, Schenk D, George-Hyslop PS, Mandelkow EM, Dobson CM, McConlogue L, Mandelkow E, Toth G. Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies. Current Alzheimer Research. 12: 814-28. PMID 26510979  1
2015 Kukic P, Kannan A, Dijkstra MJ, Abeln S, Camilloni C, Vendruscolo M. Mapping the Protein Fold Universe Using the CamTube Force Field in Molecular Dynamics Simulations. Plos Computational Biology. 11: e1004435. PMID 26505754 DOI: 10.1371/journal.pcbi.1004435  1
2015 Granata D, Baftizadeh F, Habchi J, Galvagnion C, De Simone A, Camilloni C, Laio A, Vendruscolo M. The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments. Scientific Reports. 5: 15449. PMID 26498066 DOI: 10.1038/srep15449  1
2015 Newby FN, De Simone A, Yagi-Utsumi M, Salvatella X, Dobson CM, Vendruscolo M. Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins. Biochemistry. PMID 26479087 DOI: 10.1021/acs.biochem.5b00670  1
2015 Yates EV, Müller T, Rajah L, De Genst EJ, Arosio P, Linse S, Vendruscolo M, Dobson CM, Knowles TP. Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity. Nature Chemistry. 7: 802-9. PMID 26391079 DOI: 10.1038/nchem.2344  1
2015 Joshi P, Vendruscolo M. Druggability of Intrinsically Disordered Proteins. Advances in Experimental Medicine and Biology. 870: 383-400. PMID 26387110 DOI: 10.1007/978-3-319-20164-1_13  1
2015 Fu B, Vendruscolo M. Structure and Dynamics of Intrinsically Disordered Proteins. Advances in Experimental Medicine and Biology. 870: 35-48. PMID 26387099 DOI: 10.1007/978-3-319-20164-1_2  1
2015 Wright MA, Aprile FA, Arosio P, Vendruscolo M, Dobson CM, Knowles TP. Biophysical approaches for the study of interactions between molecular chaperones and protein aggregates. Chemical Communications (Cambridge, England). 51: 14425-34. PMID 26328629 DOI: 10.1039/c5cc03689e  1
2015 Heller GT, Sormanni P, Vendruscolo M. Targeting disordered proteins with small molecules using entropy. Trends in Biochemical Sciences. 40: 491-6. PMID 26275458 DOI: 10.1016/j.tibs.2015.07.004  0.56
2015 Sormanni P, Aprile FA, Vendruscolo M. Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins. Proceedings of the National Academy of Sciences of the United States of America. 112: 9902-7. PMID 26216991 DOI: 10.1073/pnas.1422401112  0.68
2015 Collepardo-Guevara R, Portella G, Vendruscolo M, Frenkel D, Schlick T, Orozco M. Chromatin Unfolding by Epigenetic Modifications Explained by Dramatic Impairment of Internucleosome Interactions: A Multiscale Computational Study. Journal of the American Chemical Society. 137: 10205-15. PMID 26192632 DOI: 10.1021/jacs.5b04086  1
2015 Aprile FA, Sormanni P, Vendruscolo M. A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone toward a Target Substrate. Biochemistry. 54: 5103-12. PMID 26192230 DOI: 10.1021/acs.biochem.5b00459  0.68
2015 Pustovalova Y, Kukic P, Vendruscolo M, Korzhnev DM. Probing the Residual Structure of the Low Populated Denatured State of ADA2h under Folding Conditions by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy. Biochemistry. 54: 4611-22. PMID 26115097 DOI: 10.1021/acs.biochem.5b00345  0.68
2015 Borkar AN, Vallurupalli P, Camilloni C, Kay LE, Vendruscolo M. 89 Constructing free energy landscapes of RNAs at atomic resolution and characterisation of their excited states. Journal of Biomolecular Structure & Dynamics. 33: 58. PMID 26103301 DOI: 10.1080/07391102.2015.1032706  1
2015 Brewer KD, Bacaj T, Cavalli A, Camilloni C, Swarbrick JD, Liu J, Zhou A, Zhou P, Barlow N, Xu J, Seven AB, Prinslow EA, Voleti R, Häussinger D, Bonvin AM, ... ... Vendruscolo M, et al. Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution. Nature Structural & Molecular Biology. 22: 555-64. PMID 26030874 DOI: 10.1038/nsmb.3035  1
2015 Camilloni C, Vendruscolo M. Reply to "Comment on 'A Tensor-Free Method for the Structural and Dynamic Refinement of Proteins using Residual Dipolar Couplings'". The Journal of Physical Chemistry. B. 119: 8225-6. PMID 26030476 DOI: 10.1021/acs.jpcb.5b04166  1
2015 Cavalli A, Vendruscolo M. Analysis of the performance of the CHESHIRE and YAPP methods at CASD-NMR round 3. Journal of Biomolecular Nmr. PMID 25990018 DOI: 10.1007/s10858-015-9940-9  0.56
2015 Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 161: 919-32. PMID 25957690 DOI: 10.1016/j.cell.2015.03.032  1
2015 Holliday MJ, Camilloni C, Armstrong GS, Isern NG, Zhang F, Vendruscolo M, Eisenmesser EZ. Structure and Dynamics of GeoCyp: A Thermophilic Cyclophilin with a Novel Substrate Binding Mechanism That Functions Efficiently at Low Temperatures. Biochemistry. 54: 3207-17. PMID 25923019 DOI: 10.1021/acs.biochem.5b00263  1
2015 Kukic P, Alvin Leung HT, Bemporad F, Aprile FA, Kumita JR, De Simone A, Camilloni C, Vendruscolo M. Structure and dynamics of the integrin LFA-1 I-domain in the inactive state underlie its inside-out/outside-in signaling and allosteric mechanisms. Structure (London, England : 1993). 23: 745-53. PMID 25773142 DOI: 10.1016/j.str.2014.12.020  1
2015 Cohen SI, Arosio P, Presto J, Kurudenkandy FR, Biverstål H, Dolfe L, Dunning C, Yang X, Frohm B, Vendruscolo M, Johansson J, Dobson CM, Fisahn A, Knowles TP, Linse S. A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nature Structural & Molecular Biology. 22: 207-13. PMID 25686087 DOI: 10.1038/nsmb.2971  1
2015 Galvagnion C, Buell AK, Meisl G, Michaels TC, Vendruscolo M, Knowles TP, Dobson CM. Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation. Nature Chemical Biology. 11: 229-34. PMID 25643172 DOI: 10.1038/nchembio.1750  1
2015 Ciryam P, Kundra R, Morimoto RI, Dobson CM, Vendruscolo M. Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases. Trends in Pharmacological Sciences. 36: 72-7. PMID 25636813 DOI: 10.1016/j.tips.2014.12.004  1
2015 Kumar S, Vendruscolo M, Singh A, Kumar D, Samal A. Analysis of the hierarchical structure of the B. subtilis transcriptional regulatory network. Molecular Biosystems. 11: 930-41. PMID 25599335 DOI: 10.1039/c4mb00298a  1
2015 De Simone A, Aprile FA, Dhulesia A, Dobson CM, Vendruscolo M. Structure of a low-population intermediate state in the release of an enzyme product. Elife. 4. PMID 25575179 DOI: 10.7554/eLife.02777  1
2015 Sormanni P, Camilloni C, Fariselli P, Vendruscolo M. The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins. Journal of Molecular Biology. 427: 982-96. PMID 25534081 DOI: 10.1016/j.jmb.2014.12.007  1
2015 Porcari R, Proukakis C, Waudby CA, Bolognesi B, Mangione PP, Paton JF, Mullin S, Cabrita LD, Penco A, Relini A, Verona G, Vendruscolo M, Stoppini M, Tartaglia GG, Camilloni C, et al. The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein. The Journal of Biological Chemistry. 290: 2395-404. PMID 25505181 DOI: 10.1074/jbc.M114.610527  1
2015 Sormanni P, Aprile FA, Vendruscolo M. The CamSol method of rational design of protein mutants with enhanced solubility. Journal of Molecular Biology. 427: 478-90. PMID 25451785 DOI: 10.1016/j.jmb.2014.09.026  0.68
2015 Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N. Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein. Human Molecular Genetics. 24: 525-39. PMID 25217572 DOI: 10.1093/hmg/ddu472  1
2015 Camilloni C, Vendruscolo M. A tensor-free method for the structural and dynamical refinement of proteins using residual dipolar couplings. The Journal of Physical Chemistry. B. 119: 653-61. PMID 24824082 DOI: 10.1021/jp5021824  1
2014 Sanfelice D, De Simone A, Cavalli A, Faggiano S, Vendruscolo M, Pastore A. Characterization of the conformational fluctuations in the Josephin domain of ataxin-3. Biophysical Journal. 107: 2932-40. PMID 25517158 DOI: 10.1016/j.bpj.2014.10.008  1
2014 Allison JR, Rivers RC, Christodoulou JC, Vendruscolo M, Dobson CM. A relationship between the transient structure in the monomeric state and the aggregation propensities of α-synuclein and β-synuclein. Biochemistry. 53: 7170-83. PMID 25389903 DOI: 10.1021/bi5009326  1
2014 Gianni S, Camilloni C, Giri R, Toto A, Bonetti D, Morrone A, Sormanni P, Brunori M, Vendruscolo M. Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein. Proceedings of the National Academy of Sciences of the United States of America. 111: 14141-6. PMID 25228761 DOI: 10.1073/pnas.1405233111  1
2014 Boomsma W, Tian P, Frellsen J, Ferkinghoff-Borg J, Hamelryck T, Lindorff-Larsen K, Vendruscolo M. Equilibrium simulations of proteins using molecular fragment replacement and NMR chemical shifts. Proceedings of the National Academy of Sciences of the United States of America. 111: 13852-7. PMID 25192938 DOI: 10.1073/pnas.1404948111  0.52
2014 Leung HT, Kukic P, Camilloni C, Bemporad F, De Simone A, Aprile FA, Kumita JR, Vendruscolo M. NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain. Protein Science : a Publication of the Protein Society. 23: 1596-606. PMID 25147050 DOI: 10.1002/pro.2538  1
2014 Camilloni C, Sahakyan AB, Holliday MJ, Isern NG, Zhang F, Eisenmesser EZ, Vendruscolo M. Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism. Proceedings of the National Academy of Sciences of the United States of America. 111: 10203-8. PMID 24982184 DOI: 10.1073/pnas.1404220111  1
2014 Camilloni C, Vendruscolo M. Statistical mechanics of the denatured state of a protein using replica-averaged metadynamics. Journal of the American Chemical Society. 136: 8982-91. PMID 24884637 DOI: 10.1021/ja5027584  1
2014 Fusco G, De Simone A, Gopinath T, Vostrikov V, Vendruscolo M, Dobson CM, Veglia G. Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour. Nature Communications. 5: 3827. PMID 24871041 DOI: 10.1038/ncomms4827  1
2014 Knowles TP, Vendruscolo M, Dobson CM. The amyloid state and its association with protein misfolding diseases. Nature Reviews. Molecular Cell Biology. 15: 384-96. PMID 24854788 DOI: 10.1038/nrm3810  1
2014 Blombach F, Launay H, Snijders AP, Zorraquino V, Wu H, de Koning B, Brouns SJ, Ettema TJ, Camilloni C, Cavalli A, Vendruscolo M, Dickman MJ, Cabrita LD, La Teana A, Benelli D, et al. Archaeal MBF1 binds to 30S and 70S ribosomes via its helix-turn-helix domain. The Biochemical Journal. 462: 373-84. PMID 24825021 DOI: 10.1042/BJ20131474  1
2014 Buell AK, Galvagnion C, Gaspar R, Sparr E, Vendruscolo M, Knowles TP, Linse S, Dobson CM. Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America. 111: 7671-6. PMID 24817693 DOI: 10.1073/pnas.1315346111  1
2014 O'Brien EP, Ciryam P, Vendruscolo M, Dobson CM. Understanding the influence of codon translation rates on cotranslational protein folding. Accounts of Chemical Research. 47: 1536-44. PMID 24784899 DOI: 10.1021/ar5000117  1
2014 Fu B, Sahakyan AB, Camilloni C, Tartaglia GG, Paci E, Caflisch A, Vendruscolo M, Cavalli A. ALMOST: an all atom molecular simulation toolkit for protein structure determination. Journal of Computational Chemistry. 35: 1101-5. PMID 24676684 DOI: 10.1002/jcc.23588  1
2014 Cohen SI, Rajah L, Yoon CH, Buell AK, White DA, Sperling RA, Vendruscolo M, Terentjev EM, Dobson CM, Weitz DA, Knowles TP. Spatial propagation of protein polymerization. Physical Review Letters. 112: 098101. PMID 24655282 DOI: 10.1103/PhysRevLett.112.098101  1
2014 Arosio P, Vendruscolo M, Dobson CM, Knowles TP. Chemical kinetics for drug discovery to combat protein aggregation diseases. Trends in Pharmacological Sciences. 35: 127-35. PMID 24560688 DOI: 10.1016/j.tips.2013.12.005  1
2014 Tóth G, Gardai SJ, Zago W, Bertoncini CW, Cremades N, Roy SL, Tambe MA, Rochet JC, Galvagnion C, Skibinski G, Finkbeiner S, Bova M, Regnstrom K, Chiou SS, Johnston J, ... ... Vendruscolo M, et al. Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease. Plos One. 9: e87133. PMID 24551051 DOI: 10.1371/journal.pone.0087133  1
2014 Kukic P, Camilloni C, Cavalli A, Vendruscolo M. Determination of the individual roles of the linker residues in the interdomain motions of calmodulin using NMR chemical shifts. Journal of Molecular Biology. 426: 1826-38. PMID 24530797 DOI: 10.1016/j.jmb.2014.02.002  1
2014 Kannan A, Camilloni C, Sahakyan AB, Cavalli A, Vendruscolo M. A conformational ensemble derived using NMR methyl chemical shifts reveals a mechanical clamping transition that gates the binding of the HU protein to DNA. Journal of the American Chemical Society. 136: 2204-7. PMID 24517490 DOI: 10.1021/ja4105396  1
2014 Montalvao R, Camilloni C, De Simone A, Vendruscolo M. New opportunities for tensor-free calculations of residual dipolar couplings for the study of protein dynamics. Journal of Biomolecular Nmr. 58: 233-8. PMID 24477919 DOI: 10.1007/s10858-013-9801-3  1
2014 Abeln S, Vendruscolo M, Dobson CM, Frenkel D. A simple lattice model that captures protein folding, aggregation and amyloid formation. Plos One. 9: e85185. PMID 24454816 DOI: 10.1371/journal.pone.0085185  1
2014 Kendrick AA, Holliday MJ, Isern NG, Zhang F, Camilloni C, Huynh C, Vendruscolo M, Armstrong G, Eisenmesser EZ. The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide. Protein Science : a Publication of the Protein Society. 23: 464-80. PMID 24442768 DOI: 10.1002/pro.2430  1
2014 O'Brien EP, Vendruscolo M, Dobson CM. Kinetic modelling indicates that fast-translating codons can coordinate cotranslational protein folding by avoiding misfolded intermediates. Nature Communications. 5: 2988. PMID 24394622 DOI: 10.1038/ncomms3988  1
2014 Varadi M, Kosol S, Lebrun P, Valentini E, Blackledge M, Dunker AK, Felli IC, Forman-Kay JD, Kriwacki RW, Pierattelli R, Sussman J, Svergun DI, Uversky VN, Vendruscolo M, Wishart D, et al. pE-DB: a database of structural ensembles of intrinsically disordered and of unfolded proteins. Nucleic Acids Research. 42: D326-35. PMID 24174539 DOI: 10.1093/nar/gkt960  1
2013 Camilloni C, Cavalli A, Vendruscolo M. Replica-Averaged Metadynamics. Journal of Chemical Theory and Computation. 9: 5610-7. PMID 26592295 DOI: 10.1021/ct4006272  1
2013 Volpatti LR, Vendruscolo M, Dobson CM, Knowles TP. A clear view of polymorphism, twist, and chirality in amyloid fibril formation. Acs Nano. 7: 10443-8. PMID 24359171 DOI: 10.1021/nn406121w  1
2013 Debelouchina GT, Bayro MJ, Fitzpatrick AW, Ladizhansky V, Colvin MT, Caporini MA, Jaroniec CP, Bajaj VS, Rosay M, Macphee CE, Vendruscolo M, Maas WE, Dobson CM, Griffin RG. Higher order amyloid fibril structure by MAS NMR and DNP spectroscopy. Journal of the American Chemical Society. 135: 19237-47. PMID 24304221 DOI: 10.1021/ja409050a  1
2013 Ciryam P, Tartaglia GG, Morimoto RI, Dobson CM, Vendruscolo M. Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Cell Reports. 5: 781-90. PMID 24183671 DOI: 10.1016/j.celrep.2013.09.043  1
2013 Tsytlonok M, Sormanni P, Rowling PJ, Vendruscolo M, Itzhaki LS. Subdomain architecture and stability of a giant repeat protein. The Journal of Physical Chemistry. B. 117: 13029-37. PMID 24053231 DOI: 10.1021/jp402360x  0.56
2013 Biedermann F, Vendruscolo M, Scherman OA, De Simone A, Nau WM. Cucurbit[8]uril and blue-box: high-energy water release overwhelms electrostatic interactions. Journal of the American Chemical Society. 135: 14879-88. PMID 23991836 DOI: 10.1021/ja407951x  1
2013 Waudby CA, Camilloni C, Fitzpatrick AW, Cabrita LD, Dobson CM, Vendruscolo M, Christodoulou J. In-cell NMR characterization of the secondary structure populations of a disordered conformation of α-synuclein within E. coli cells. Plos One. 8: e72286. PMID 23991082 DOI: 10.1371/journal.pone.0072286  1
2013 De Simone A, Gustavsson M, Montalvao RW, Shi L, Veglia G, Vendruscolo M. Structures of the excited states of phospholamban and shifts in their populations upon phosphorylation. Biochemistry. 52: 6684-94. PMID 23968132 DOI: 10.1021/bi400517b  1
2013 De Simone A, Montalvao RW, Dobson CM, Vendruscolo M. Characterization of the interdomain motions in hen lysozyme using residual dipolar couplings as replica-averaged structural restraints in molecular dynamics simulations. Biochemistry. 52: 6480-6. PMID 23941501 DOI: 10.1021/bi4007513  1
2013 Camilloni C, Vendruscolo M. A relationship between the aggregation rates of α-synuclein variants and the β-sheet populations in their monomeric forms. The Journal of Physical Chemistry. B. 117: 10737-41. PMID 23941114 DOI: 10.1021/jp405614j  1
2013 Zhu M, De Simone A, Schenk D, Toth G, Dobson CM, Vendruscolo M. Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide. The Journal of Chemical Physics. 139: 035101. PMID 23883055 DOI: 10.1063/1.4811831  1
2013 Suardíaz R, Sahakyan AB, Vendruscolo M. A geometrical parametrization of C1'-C5' RNA ribose chemical shifts calculated by density functional theory. The Journal of Chemical Physics. 139: 034101. PMID 23883004 DOI: 10.1063/1.4811498  1
2013 Horrocks MH, Rajah L, Jönsson P, Kjaergaard M, Vendruscolo M, Knowles TP, Klenerman D. Single-molecule measurements of transient biomolecular complexes through microfluidic dilution. Analytical Chemistry. 85: 6855-9. PMID 23782428 DOI: 10.1021/ac4010875  1
2013 Borkar AN, De Simone A, Montalvao RW, Vendruscolo M. A method of determining RNA conformational ensembles using structure-based calculations of residual dipolar couplings. The Journal of Chemical Physics. 138: 215103. PMID 23758399 DOI: 10.1063/1.4804301  1
2013 Cohen SI, Linse S, Luheshi LM, Hellstrand E, White DA, Rajah L, Otzen DE, Vendruscolo M, Dobson CM, Knowles TP. Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism. Proceedings of the National Academy of Sciences of the United States of America. 110: 9758-63. PMID 23703910 DOI: 10.1073/pnas.1218402110  1
2013 Granata D, Camilloni C, Vendruscolo M, Laio A. Characterization of the free-energy landscapes of proteins by NMR-guided metadynamics. Proceedings of the National Academy of Sciences of the United States of America. 110: 6817-22. PMID 23572592 DOI: 10.1073/pnas.1218350110  1
2013 Guilliams T, El-Turk F, Buell AK, O'Day EM, Aprile FA, Esbjörner EK, Vendruscolo M, Cremades N, Pardon E, Wyns L, Welland ME, Steyaert J, Christodoulou J, Dobson CM, De Genst E. Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages. Journal of Molecular Biology. 425: 2397-411. PMID 23557833 DOI: 10.1016/j.jmb.2013.01.040  1
2013 Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, ... ... Vendruscolo M, et al. Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proceedings of the National Academy of Sciences of the United States of America. 110: 5468-73. PMID 23513222 DOI: 10.1073/pnas.1219476110  1
2013 Vendruscolo M, Dobson CM. Structural biology: Protein self-assembly intermediates. Nature Chemical Biology. 9: 216-7. PMID 23508184 DOI: 10.1038/nchembio.1210  1
2013 Cavalli A, Camilloni C, Vendruscolo M. Molecular dynamics simulations with replica-averaged structural restraints generate structural ensembles according to the maximum entropy principle. The Journal of Chemical Physics. 138: 094112. PMID 23485282 DOI: 10.1063/1.4793625  1
2013 Sahakyan AB, Vendruscolo M. Analysis of the contributions of ring current and electric field effects to the chemical shifts of RNA bases. The Journal of Physical Chemistry. B. 117: 1989-98. PMID 23398371 DOI: 10.1021/jp3057306  1
2013 Camilloni C, Cavalli A, Vendruscolo M. Assessment of the use of NMR chemical shifts as replica-averaged structural restraints in molecular dynamics simulations to characterize the dynamics of proteins. The Journal of Physical Chemistry. B. 117: 1838-43. PMID 23327201 DOI: 10.1021/jp3106666  1
2013 Ciryam P, Morimoto RI, Vendruscolo M, Dobson CM, O'Brien EP. In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proceedings of the National Academy of Sciences of the United States of America. 110: E132-40. PMID 23256155 DOI: 10.1073/pnas.1213624110  1
2012 Knowles TP, De Simone A, Fitzpatrick AW, Baldwin A, Meehan S, Rajah L, Vendruscolo M, Welland ME, Dobson CM, Terentjev EM. Twisting transition between crystalline and fibrillar phases of aggregated peptides. Physical Review Letters. 109: 158101. PMID 23102370  0.84
2012 Roodveldt C, Andersson A, De Genst EJ, Labrador-Garrido A, Buell AK, Dobson CM, Tartaglia GG, Vendruscolo M. A rationally designed six-residue swap generates comparability in the aggregation behavior of α-synuclein and β-synuclein. Biochemistry. 51: 8771-8. PMID 23003198 DOI: 10.1021/bi300558q  1
2012 Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, ... ... Vendruscolo M, et al. In support of the BMRB. Nature Structural & Molecular Biology. 19: 854-60. PMID 22955930 DOI: 10.1038/nsmb.2371  0.48
2012 Chambers JE, Petrova K, Tomba G, Vendruscolo M, Ron D. ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load. The Journal of Cell Biology. 198: 371-85. PMID 22869598 DOI: 10.1083/jcb.201202005  1
2012 Montalvao RW, De Simone A, Vendruscolo M. Determination of structural fluctuations of proteins from structure-based calculations of residual dipolar couplings. Journal of Biomolecular Nmr. 53: 281-92. PMID 22729708 DOI: 10.1007/s10858-012-9644-3  1
2012 O'Brien EP, Christodoulou J, Vendruscolo M, Dobson CM. Trigger factor slows co-translational folding through kinetic trapping while sterically protecting the nascent chain from aberrant cytosolic interactions. Journal of the American Chemical Society. 134: 10920-32. PMID 22680285 DOI: 10.1021/ja302305u  1
2012 O'Brien EP, Vendruscolo M, Dobson CM. Prediction of variable translation rate effects on cotranslational protein folding. Nature Communications. 3: 868. PMID 22643895 DOI: 10.1038/ncomms1850  1
2012 Chen J, Yagi H, Sormanni P, Vendruscolo M, Makabe K, Nakamura T, Goto Y, Kuwajima K. Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone. Febs Letters. 586: 1120-7. PMID 22575645 DOI: 10.1016/j.febslet.2012.03.019  0.56
2012 Neudecker P, Robustelli P, Cavalli A, Walsh P, Lundström P, Zarrine-Afsar A, Sharpe S, Vendruscolo M, Kay LE. Structure of an intermediate state in protein folding and aggregation. Science (New York, N.Y.). 336: 362-6. PMID 22517863 DOI: 10.1126/science.1214203  1
2012 Sahakyan AB, Cavalli A, Vranken WF, Vendruscolo M. Protein structure validation using side-chain chemical shifts. The Journal of Physical Chemistry. B. 116: 4754-9. PMID 22455760 DOI: 10.1021/jp2122054  1
2012 Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. From macroscopic measurements to microscopic mechanisms of protein aggregation. Journal of Molecular Biology. 421: 160-71. PMID 22406275 DOI: 10.1016/j.jmb.2012.02.031  1
2012 Camilloni C, De Simone A, Vranken WF, Vendruscolo M. Determination of secondary structure populations in disordered states of proteins using nuclear magnetic resonance chemical shifts. Biochemistry. 51: 2224-31. PMID 22360139 DOI: 10.1021/bi3001825  1
2012 Rosato A, Aramini JM, Arrowsmith C, Bagaria A, Baker D, Cavalli A, Doreleijers JF, Eletsky A, Giachetti A, Guerry P, Gutmanas A, Güntert P, He Y, Herrmann T, Huang YJ, ... ... Vendruscolo M, et al. Blind testing of routine, fully automated determination of protein structures from NMR data. Structure (London, England : 1993). 20: 227-36. PMID 22325772 DOI: 10.1016/j.str.2012.01.002  1
2012 Camilloni C, Robustelli P, De Simone A, Cavalli A, Vendruscolo M. Characterization of the conformational equilibrium between the two major substates of RNase A using NMR chemical shifts. Journal of the American Chemical Society. 134: 3968-71. PMID 22320129 DOI: 10.1021/ja210951z  1
2012 Agostini F, Vendruscolo M, Tartaglia GG. Sequence-based prediction of protein solubility. Journal of Molecular Biology. 421: 237-41. PMID 22172487 DOI: 10.1016/j.jmb.2011.12.005  0.52
2012 Murakami T, Yang SP, Xie L, Kawano T, Fu D, Mukai A, Bohm C, Chen F, Robertson J, Suzuki H, Tartaglia GG, Vendruscolo M, Kaminski Schierle GS, Chan FT, Moloney A, et al. ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism. Human Molecular Genetics. 21: 1-9. PMID 21949354 DOI: 10.1093/hmg/ddr417  1
2012 Fusco G, De Simone A, Hsu ST, Bemporad F, Vendruscolo M, Chiti F, Dobson CM. ¹H, ¹³C and ¹⁵N resonance assignments of human muscle acylphosphatase. Biomolecular Nmr Assignments. 6: 27-9. PMID 21643968 DOI: 10.1007/s12104-011-9318-1  1
2011 De Simone A, Montalvao RW, Vendruscolo M. Determination of Conformational Equilibria in Proteins Using Residual Dipolar Couplings. Journal of Chemical Theory and Computation. 7: 4189-4195. PMID 22180735 DOI: 10.1021/ct200361b  1
2011 De Simone A, Dhulesia A, Soldi G, Vendruscolo M, Hsu ST, Chiti F, Dobson CM. Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility. Proceedings of the National Academy of Sciences of the United States of America. 108: 21057-62. PMID 22160682 DOI: 10.1073/pnas.1112197108  1
2011 Fitzpatrick AW, Knowles TP, Waudby CA, Vendruscolo M, Dobson CM. Inversion of the balance between hydrophobic and hydrogen bonding interactions in protein folding and aggregation. Plos Computational Biology. 7: e1002169. PMID 22022239 DOI: 10.1371/journal.pcbi.1002169  1
2011 Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Nucleated polymerisation in the presence of pre-formed seed filaments. International Journal of Molecular Sciences. 12: 5844-52. PMID 22016630 DOI: 10.3390/ijms12095844  1
2011 Sahakyan AB, Vranken WF, Cavalli A, Vendruscolo M. Using side-chain aromatic proton chemical shifts for a quantitative analysis of protein structures. Angewandte Chemie (International Ed. in English). 50: 9620-3. PMID 21887824 DOI: 10.1002/anie.201101641  1
2011 Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Nucleated polymerization with secondary pathways. III. Equilibrium behavior and oligomer populations. The Journal of Chemical Physics. 135: 065107. PMID 21842956 DOI: 10.1063/1.3608918  1
2011 Cohen SI, Vendruscolo M, Dobson CM, Knowles TP. Nucleated polymerization with secondary pathways. II. Determination of self-consistent solutions to growth processes described by non-linear master equations. The Journal of Chemical Physics. 135: 065106. PMID 21842955 DOI: 10.1063/1.3608917  1
2011 Cohen SI, Vendruscolo M, Welland ME, Dobson CM, Terentjev EM, Knowles TP. Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments. The Journal of Chemical Physics. 135: 065105. PMID 21842954 DOI: 10.1063/1.3608916  1
2011 Vendruscolo M, Knowles TP, Dobson CM. Protein solubility and protein homeostasis: a generic view of protein misfolding disorders. Cold Spring Harbor Perspectives in Biology. 3. PMID 21825020 DOI: 10.1101/cshperspect.a010454  1
2011 Sahakyan AB, Vranken WF, Cavalli A, Vendruscolo M. Structure-based prediction of methyl chemical shifts in proteins. Journal of Biomolecular Nmr. 50: 331-46. PMID 21748266 DOI: 10.1007/s10858-011-9524-2  1
2011 Kohlhoff KJ, Jahn TR, Lomas DA, Dobson CM, Crowther DC, Vendruscolo M. The iFly tracking system for an automated locomotor and behavioural analysis of Drosophila melanogaster. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 755-60. PMID 21698336 DOI: 10.1039/c0ib00149j  1
2011 Baldwin AJ, Knowles TP, Tartaglia GG, Fitzpatrick AW, Devlin GL, Shammas SL, Waudby CA, Mossuto MF, Meehan S, Gras SL, Christodoulou J, Anthony-Cahill SJ, Barker PD, Vendruscolo M, Dobson CM. Metastability of native proteins and the phenomenon of amyloid formation. Journal of the American Chemical Society. 133: 14160-3. PMID 21650202 DOI: 10.1021/ja2017703  1
2011 Cavalli A, Montalvao RW, Vendruscolo M. Using chemical shifts to determine structural changes in proteins upon complex formation. The Journal of Physical Chemistry. B. 115: 9491-4. PMID 21639128 DOI: 10.1021/jp202647q  0.6
2011 Jahn TR, Kohlhoff KJ, Scott M, Tartaglia GG, Lomas DA, Dobson CM, Vendruscolo M, Crowther DC. Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease. Journal of Neuroscience Methods. 197: 186-9. PMID 21315762 DOI: 10.1016/j.jneumeth.2011.01.026  1
2011 Raimondi S, Guglielmi F, Giorgetti S, Di Gaetano S, Arciello A, Monti DM, Relini A, Nichino D, Doglia SM, Natalello A, Pucci P, Mangione P, Obici L, Merlini G, Stoppini M, ... ... Vendruscolo M, et al. Effects of the known pathogenic mutations on the aggregation pathway of the amyloidogenic peptide of apolipoprotein A-I. Journal of Molecular Biology. 407: 465-76. PMID 21296086 DOI: 10.1016/j.jmb.2011.01.044  1
2011 Vendruscolo M, Dobson CM. Protein dynamics: Moore's law in molecular biology. Current Biology : Cb. 21: R68-70. PMID 21256436 DOI: 10.1016/j.cub.2010.11.062  1
2011 Olzscha H, Schermann SM, Woerner AC, Pinkert S, Hecht MH, Tartaglia GG, Vendruscolo M, Hayer-Hartl M, Hartl FU, Vabulas RM. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell. 144: 67-78. PMID 21215370 DOI: 10.1016/j.cell.2010.11.050  1
2009 Kohlhoff KJ, Robustelli P, Cavalli A, Salvatella X, Vendruscolo M. Fast and accurate predictions of protein NMR chemical shifts from interatomic distances. Journal of the American Chemical Society. 131: 13894-5. PMID 19739624 DOI: 10.1021/ja903772t  0.56
2007 Auer S, Miller MA, Krivov SV, Dobson CM, Karplus M, Vendruscolo M. Importance of metastable states in the free energy landscapes of polypeptide chains. Physical Review Letters. 99: 178104. PMID 17995375 DOI: 10.1103/PhysRevLett.99.178104  1
2005 Paci E, Lindorff-Larsen K, Dobson CM, Karplus M, Vendruscolo M. Transition state contact orders correlate with protein folding rates. Journal of Molecular Biology. 352: 495-500. PMID 16120445 DOI: 10.1016/j.jmb.2005.06.081  1
2004 Paci E, Friel CT, Lindorff-Larsen K, Radford SE, Karplus M, Vendruscolo M. Comparison of the transition state ensembles for folding of Im7 and Im9 determined using all-atom molecular dynamics simulations with phi value restraints. Proteins. 54: 513-25. PMID 14747999 DOI: 10.1002/prot.10595  1
2003 Vendruscolo M, Paci E, Dobson CM, Karplus M. Rare fluctuations of native proteins sampled by equilibrium hydrogen exchange. Journal of the American Chemical Society. 125: 15686-7. PMID 14677926 DOI: 10.1021/ja036523z  1
2003 Vendruscolo M, Paci E, Karplus M, Dobson CM. Structures and relative free energies of partially folded states of proteins. Proceedings of the National Academy of Sciences of the United States of America. 100: 14817-21. PMID 14657374 DOI: 10.1073/pnas.2036516100  1
2003 Paci E, Clarke J, Steward A, Vendruscolo M, Karplus M. Self-consistent determination of the transition state for protein folding: application to a fibronectin type III domain. Proceedings of the National Academy of Sciences of the United States of America. 100: 394-9. PMID 12515856 DOI: 10.1073/pnas.232704999  1
2002 Paci E, Vendruscolo M, Karplus M. Validity of Gō models: comparison with a solvent-shielded empirical energy decomposition. Biophysical Journal. 83: 3032-8. PMID 12496075 DOI: 10.1016/S0006-3495(02)75308-3  1
2002 Paci E, Vendruscolo M, Dobson CM, Karplus M. Determination of a transition state at atomic resolution from protein engineering data. Journal of Molecular Biology. 324: 151-63. PMID 12421565 DOI: 10.1016/S0022-2836(02)00944-0  1
2002 Vendruscolo M, Dokholyan NV, Paci E, Karplus M. Small-world view of the amino acids that play a key role in protein folding. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 65: 061910. PMID 12188762 DOI: 10.1103/PhysRevE.65.061910  1
2002 Paci E, Vendruscolo M, Karplus M. Native and non-native interactions along protein folding and unfolding pathways Proteins: Structure, Function and Genetics. 47: 379-392. PMID 11948791 DOI: 10.1002/prot.10089  1
2001 Vendruscolo M, Paci E, Dobson CM, Karplus M. Three key residues form a critical contact network in a protein folding transition state. Nature. 409: 641-5. PMID 11214326 DOI: 10.1038/35054591  0.84
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