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Alejandro Chavez, Ph.D. - Publications

Affiliations: 
2010 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Molecular Biology, Genetics, Biochemistry
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH. Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases. Biorxiv : the Preprint Server For Biology. PMID 36993517 DOI: 10.1101/2023.03.17.533036  0.371
2023 Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH. Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases. Nature Biotechnology. PMID 36991112 DOI: 10.1038/s41587-023-01748-1  0.341
2020 Moghadam F, LeGraw R, Velazquez JJ, Yeo NC, Xu C, Park J, Chavez A, Ebrahimkhani MR, Kiani S. Synthetic immunomodulation with a CRISPR super-repressor in vivo. Nature Cell Biology. 22: 1143-1154. PMID 32884147 DOI: 10.1038/S41556-020-0563-3  0.353
2019 Halder V, Porter CBM, Chavez A, Shapiro RS. Author Correction: Design, execution, and analysis of CRISPR-Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans. Nature Protocols. PMID 30976123 DOI: 10.1038/S41596-019-0157-3  0.318
2019 Xiong K, Marquart KF, Karottki KJC, Li S, Shamie I, Lee JS, Gerling S, Yeo NC, Chavez A, Lee GM, Lewis NE, Kildegaard HF. Reduced Apoptosis in Chinese Hamster Ovary Cells via Optimized CRISPR Interference. Biotechnology and Bioengineering. PMID 30883679 DOI: 10.1002/Bit.26969  0.305
2019 Labun K, Guo X, Chavez A, Church G, Gagnon JA, Valen E. Accurate analysis of genuine CRISPR editing events with ampliCan. Genome Research. PMID 30850374 DOI: 10.1101/Gr.244293.118  0.321
2019 Halder V, Porter CBM, Chavez A, Shapiro RS. Design, execution, and analysis of CRISPR-Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans. Nature Protocols. PMID 30737491 DOI: 10.1038/S41596-018-0122-6  0.345
2018 Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, et al. An enhanced CRISPR repressor for targeted mammalian gene regulation. Nature Methods. PMID 30013045 DOI: 10.1038/S41592-018-0048-5  0.339
2018 Clarke R, Heler R, MacDougall MS, Yeo NC, Chavez A, Regan M, Hanakahi L, Church GM, Marraffini LA, Merrill BJ. Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks. Molecular Cell. 71: 42-55.e8. PMID 29979968 DOI: 10.1016/J.Molcel.2018.06.005  0.409
2018 Guo X, Chavez A, Tung A, Chan Y, Kaas C, Yin Y, Cecchi R, Garnier SL, Kelsic ED, Schubert M, DiCarlo JE, Collins JJ, Church GM. High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast. Nature Biotechnology. PMID 29786095 DOI: 10.1038/Nbt.4147  0.436
2018 Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP. An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance. Cell. 173: 649-664.e20. PMID 29677511 DOI: 10.1016/J.Cell.2018.03.052  0.337
2018 Chavez A, Pruitt BW, Tuttle M, Shapiro RS, Cecchi RJ, Winston J, Turczyk BM, Tung M, Collins JJ, Church GM. Precise Cas9 targeting enables genomic mutation prevention. Proceedings of the National Academy of Sciences of the United States of America. PMID 29555762 DOI: 10.1073/Pnas.1718148115  0.328
2017 Shapiro RS, Chavez A, Porter CBM, Hamblin M, Kaas CS, DiCarlo JE, Zeng G, Xu X, Revtovich AV, Kirienko NV, Wang Y, Church GM, Collins JJ. A CRISPR-Cas9-based gene drive platform for genetic interaction analysis in Candida albicans. Nature Microbiology. PMID 29062088 DOI: 10.1038/S41564-017-0043-0  0.358
2017 Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nature Microbiology. 2: 16274. PMID 28165460 DOI: 10.1038/Nmicrobiol.2016.274  0.348
2016 Chavez A, Tuttle M, Pruitt BW, Ewen-Campen B, Chari R, Ter-Ovanesyan D, Haque SJ, Cecchi RJ, Kowal EJ, Buchthal J, Housden BE, Perrimon N, Collins JJ, Church G. Comparison of Cas9 activators in multiple species. Nature Methods. PMID 27214048 DOI: 10.1038/Nmeth.3871  0.319
2015 DiCarlo JE, Chavez A, Dietz SL, Esvelt KM, Church GM. Safeguarding CRISPR-Cas9 gene drives in yeast. Nature Biotechnology. 33: 1250-1255. PMID 26571100 DOI: 10.1038/Nbt.3412  0.348
2015 Kiani S, Chavez A, Tuttle M, Hall RN, Chari R, Ter-Ovanesyan D, Qian J, Pruitt BW, Beal J, Vora S, Buchthal J, Kowal EJ, Ebrahimkhani MR, Collins JJ, Weiss R, et al. Cas9 gRNA engineering for genome editing, activation and repression. Nature Methods. 12: 1051-4. PMID 26344044 DOI: 10.1038/Nmeth.3580  0.358
2015 Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, et al. Highly efficient Cas9-mediated transcriptional programming. Nature Methods. 12: 326-8. PMID 25730490 DOI: 10.1038/Nmeth.3312  0.326
2014 Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman P, Mar BG, Lindsley RC, Mermel C, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kinnunen L, Koistinen H, Ladenvall C, et al. Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes Blood. 124: 840-840. DOI: 10.1182/Blood.V124.21.840.840  0.316
2013 Glineburg MR, Chavez A, Agrawal V, Brill SJ, Johnson FB. Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication. The Journal of Biological Chemistry. 288: 33193-204. PMID 24100144 DOI: 10.1074/Jbc.M113.496133  0.565
2013 Platt JM, Ryvkin P, Wanat JJ, Donahue G, Ricketts MD, Barrett SP, Waters HJ, Song S, Chavez A, Abdallah KO, Master SR, Wang LS, Johnson FB. Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence. Genes & Development. 27: 1406-20. PMID 23756653 DOI: 10.1101/gad.218776.113  0.538
2011 Chavez A, Agrawal V, Johnson FB. Homologous recombination-dependent rescue of deficiency in the structural maintenance of chromosomes (Smc) 5/6 complex. The Journal of Biological Chemistry. 286: 5119-25. PMID 21138837 DOI: 10.1074/Jbc.M110.201608  0.605
2010 Chavez A, George V, Agrawal V, Johnson FB. Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution. The Journal of Biological Chemistry. 285: 11922-30. PMID 20159973 DOI: 10.1074/Jbc.M109.041277  0.586
2010 Kozak ML, Chavez A, Dang W, Berger SL, Ashok A, Guo X, Johnson FB. Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction. The Embo Journal. 29: 158-70. PMID 19875981 DOI: 10.1038/Emboj.2009.314  0.552
2009 Chavez A, Tsou AM, Johnson FB. Telomeres do the (un)twist: helicase actions at chromosome termini. Biochimica Et Biophysica Acta. 1792: 329-40. PMID 19245831 DOI: 10.1016/J.Bbadis.2009.02.008  0.593
2008 Lee JY, Mogen JL, Chavez A, Johnson FB. Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination. The Journal of Biological Chemistry. 283: 29847-58. PMID 18757364 DOI: 10.1074/Jbc.M804760200  0.593
2007 Turaga RV, Massip L, Chavez A, Johnson FB, Lebel M. Werner syndrome protein prevents DNA breaks upon chromatin structure alteration. Aging Cell. 6: 471-81. PMID 17521388 DOI: 10.1111/J.1474-9726.2007.00301.X  0.59
2004 Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proceedings of the National Academy of Sciences of the United States of America. 101: 6403-8. PMID 15084750 DOI: 10.1073/Pnas.0307697101  0.315
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