| Year |
Citation |
Score |
| 2019 |
Wichapong K, Poelman H, Ercig B, Hrdinova J, Liu X, Lutgens E, Nicolaes GA. Rational modulator design by exploitation of protein-protein complex structures. Future Medicinal Chemistry. PMID 31141413 DOI: 10.4155/Fmc-2018-0433 |
0.327 |
|
| 2017 |
von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, ... ... Nicolaes GA, et al. Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation. Science Translational Medicine. 9. PMID 28381538 DOI: 10.1126/Scitranslmed.Aah6650 |
0.336 |
|
| 2016 |
Wichapong K, Alard JE, Ortega-Gomez A, Weber C, Hackeng TM, Soehnlein O, Nicolaes GA. Structure-Based Design of Peptidic Inhibitors of the Interaction between Chemokine 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1). Journal of Medicinal Chemistry. PMID 26871718 DOI: 10.1021/Acs.Jmedchem.5B01952 |
0.335 |
|
| 2015 |
Labbé CM, Kuenemann MA, Zarzycka B, Vriend G, Nicolaes GA, Lagorce D, Miteva MA, Villoutreix BO, Sperandio O. iPPI-DB: an online database of modulators of protein-protein interactions. Nucleic Acids Research. PMID 26432833 DOI: 10.1093/Nar/Gkv982 |
0.315 |
|
| 2015 |
De Waelheyns E, Segers K, Sardis MF, Anné J, Nicolaes GA, Economou A. Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening. The Journal of Antibiotics. 68: 666-73. PMID 25990955 DOI: 10.1038/Ja.2015.53 |
0.338 |
|
| 2015 |
Du J, Wichapong K, Hackeng KM, Nicolaes GA. Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding. Thrombosis and Haemostasis. 113: 373-84. PMID 25354705 DOI: 10.1160/Th14-02-0180 |
0.345 |
|
| 2014 |
Du J, Nicolaes GA, Kruijswijk D, Versloot M, van der Poll T, van 't Veer C. The structure function of the death domain of human IRAK-M. Cell Communication and Signaling : Ccs. 12: 77. PMID 25481771 DOI: 10.1186/S12964-014-0077-3 |
0.333 |
|
| 2014 |
Studer RA, Opperdoes FR, Nicolaes GA, Mulder AB, Mulder R. Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach. Open Biology. 4. PMID 25339693 DOI: 10.1098/Rsob.140121 |
0.368 |
|
| 2014 |
Chaves RC, Dahmane S, Odorico M, Nicolaes GA, Pellequer JL. Factor Va alternative conformation reconstruction using atomic force microscopy. Thrombosis and Haemostasis. 112: 1167-73. PMID 25185589 DOI: 10.1160/Th14-06-0481 |
0.33 |
|
| 2014 |
Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, Nicolaes GA. Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis. Plos One. 9: e101446. PMID 25032959 DOI: 10.1371/Journal.Pone.0101446 |
0.307 |
|
| 2014 |
Sperandio O, Wildhagen KC, Schrijver R, Wielders S, Villoutreix BO, Nicolaes GA. Identification of novel small molecule inhibitors of activated protein C. Thrombosis Research. 133: 1105-14. PMID 24513148 DOI: 10.1016/J.Thromres.2014.01.026 |
0.421 |
|
| 2014 |
Wildhagen KC, García de Frutos P, Reutelingsperger CP, Schrijver R, Aresté C, Ortega-Gómez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA. Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood. 123: 1098-101. PMID 24264231 DOI: 10.1182/Blood-2013-07-514984 |
0.49 |
|
| 2014 |
Nicolaes GA, Kulharia M, Voorberg J, Kaijen PH, Wroblewska A, Wielders S, Schrijver R, Sperandio O, Villoutreix BO. Rational design of small molecules targeting the C2 domain of coagulation factor VIII. Blood. 123: 113-20. PMID 24227818 DOI: 10.1182/Blood-2013-05-503227 |
0.413 |
|
| 2013 |
Schuijt TJ, Bakhtiari K, Daffre S, Deponte K, Wielders SJ, Marquart JA, Hovius JW, van der Poll T, Fikrig E, Bunce MW, Camire RM, Nicolaes GA, Meijers JC, van 't Veer C. Factor Xa activation of factor V is of paramount importance in initiating the coagulation system: lessons from a tick salivary protein. Circulation. 128: 254-66. PMID 23817575 DOI: 10.1161/Circulationaha.113.003191 |
0.464 |
|
| 2012 |
Mencarelli C, Bode GH, Losen M, Kulharia M, Molenaar PC, Veerhuis R, Steinbusch HW, De Baets MH, Nicolaes GA, Martinez-Martinez P. Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques. The Journal of Biological Chemistry. 287: 14897-911. PMID 22396542 DOI: 10.1074/Jbc.M111.299545 |
0.332 |
|
| 2011 |
Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA. The structure-function relationship of activated protein C. Lessons from natural and engineered mutations. Thrombosis and Haemostasis. 106: 1034-45. PMID 22072231 DOI: 10.1160/Th11-08-0522 |
0.448 |
|
| 2011 |
Gerards M, van den Bosch BJ, Danhauser K, Serre V, van Weeghel M, Wanders RJ, Nicolaes GA, Sluiter W, Schoonderwoerd K, Scholte HR, Prokisch H, Rötig A, de Coo IF, Smeets HJ. Riboflavin-responsive oxidative phosphorylation complex I deficiency caused by defective ACAD9: new function for an old gene. Brain : a Journal of Neurology. 134: 210-9. PMID 20929961 DOI: 10.1093/Brain/Awq273 |
0.316 |
|
| 2010 |
Yamazaki T, Okada H, Balling KW, Dahlbäck B, Nicolaes GA. The D2194G mutation is responsible for increased levels of FV1 in carriers of the factor V R2 haplotype. Thrombosis and Haemostasis. 104: 860-1. PMID 20694279 DOI: 10.1160/Th10-03-0180 |
0.524 |
|
| 2010 |
Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J. Inhibition of thrombin formation by active site mutated (S360A) activated protein C. The Journal of Biological Chemistry. 285: 22890-900. PMID 20484050 DOI: 10.1074/Jbc.M110.131029 |
0.766 |
|
| 2010 |
Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. The Journal of Biological Chemistry. 285: 8824-9. PMID 20089867 DOI: 10.1074/Jbc.M109.080168 |
0.407 |
|
| 2009 |
Hartmann R, Dockal M, Kammlander W, Panholzer E, Nicolaes GA, Fiedler C, Rosing J, Scheiflinger F. Factor IX mutants with enhanced catalytic activity. Journal of Thrombosis and Haemostasis : Jth. 7: 1656-62. PMID 19656280 DOI: 10.1111/J.1538-7836.2009.03560.X |
0.679 |
|
| 2008 |
Jeimy SB, Fuller N, Tasneem S, Segers K, Stafford AR, Weitz JI, Camire RM, Nicolaes GA, Hayward CP. Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation. Thrombosis and Haemostasis. 100: 1058-67. PMID 19132231 DOI: 10.1160/Th08-05-0307 |
0.444 |
|
| 2008 |
Sperandio O, Miteva MA, Segers K, Nicolaes GA, Villoutreix BO. Screening Outside the Catalytic Site: Inhibition of Macromolecular Inter-actions Through Structure-Based Virtual Ligand Screening Experiments. The Open Biochemistry Journal. 2: 29-37. PMID 18949072 DOI: 10.2174/1874091X00802010029 |
0.345 |
|
| 2008 |
Segers K, Dahlbäck B, Rosing J, Nicolaes GA. Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin. The Journal of Biological Chemistry. 283: 22573-81. PMID 18519572 DOI: 10.1074/Jbc.M801724200 |
0.746 |
|
| 2008 |
Maurissen LF, Thomassen MC, Nicolaes GA, Dahlbäck B, Tans G, Rosing J, Hackeng TM. Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation. Blood. 111: 3034-41. PMID 18160668 DOI: 10.1182/Blood-2007-06-089987 |
0.747 |
|
| 2008 |
Stoilova-McPhie S, Parmenter CD, Segers K, Villoutreix BO, Nicolaes GA. Defining the structure of membrane-bound human blood coagulation factor Va. Journal of Thrombosis and Haemostasis : Jth. 6: 76-82. PMID 17949476 DOI: 10.1111/J.1538-7836.2007.02810.X |
0.379 |
|
| 2007 |
Segers K, Dahlbäck B, Bock PE, Tans G, Rosing J, Nicolaes GA. The role of thrombin exosites I and II in the activation of human coagulation factor V. The Journal of Biological Chemistry. 282: 33915-24. PMID 17878169 DOI: 10.1074/Jbc.M701123200 |
0.752 |
|
| 2007 |
Segers K, Dahlbäck B, Nicolaes GA. Coagulation factor V and thrombophilia: background and mechanisms. Thrombosis and Haemostasis. 98: 530-42. PMID 17849041 DOI: 10.1160/Th07-02-0150 |
0.59 |
|
| 2007 |
Segers K, Sperandio O, Sack M, Fischer R, Miteva MA, Rosing J, Nicolaes GA, Villoutreix BO. Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V. Proceedings of the National Academy of Sciences of the United States of America. 104: 12697-702. PMID 17646652 DOI: 10.1073/Pnas.0701051104 |
0.666 |
|
| 2007 |
Kroh HK, Tans G, Nicolaes GA, Rosing J, Bock PE. Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation. The Journal of Biological Chemistry. 282: 16095-104. PMID 17430903 DOI: 10.1074/Jbc.M610577200 |
0.685 |
|
| 2007 |
Maurissen L, Thomassen S, Nicolaes G, Dahlbäck B, Tans G, Rosing J, Hackeng T. PROTEIN S-C4BP COMPLEX STIMULATES ACTIVATED PROTEIN C-MEDIATED INACTIVATION AT R306 BUT INHIBITS INACTIVATION AT R506 IN FACTOR VA Journal of Thrombosis and Haemostasis. 5: P-M-082-P-M-082. DOI: 10.1111/J.1538-7836.2007.Tb01004.X |
0.722 |
|
| 2006 |
Nicolaes GA, Hackeng TM, Segers K, Rosing J. A structural model of the SHBG domain of human variant protein S Heerlen. Thrombosis and Haemostasis. 96: 538-40. PMID 17003935 DOI: 10.1160/Th06-07-0361 |
0.631 |
|
| 2006 |
Segers K, Rosing J, Nicolaes GA. Structural models of the snake venom factor V activators from Daboia russelli and Daboia lebetina. Proteins. 64: 968-84. PMID 16807918 DOI: 10.1002/Prot.21051 |
0.725 |
|
| 2006 |
Tasneem S, Jeimy SB, Fuller N, McKay H, Nicolaes GA, Hayward CP. Effects of Multimerin 1 on Platelet and Plasma FV as Determined by Calibrated Automated Thrombography. Blood. 108: 1607-1607. DOI: 10.1182/Blood.V108.11.1607.1607 |
0.349 |
|
| 2004 |
Jeimy SB, Woram RA, Fuller N, Quinn-Allen MA, Nicolaes GA, Dahlbäck B, Kane WH, Hayward CP. Identification of the MMRN1 binding region within the C2 domain of human factor V. The Journal of Biological Chemistry. 279: 51466-71. PMID 15452129 DOI: 10.1074/jbc.M409866200 |
0.546 |
|
| 2004 |
Nicolaes GA, Sørensen KW, Friedrich U, Tans G, Rosing J, Autin L, Dahlbäck B, Villoutreix BO. Altered inactivation pathway of factor Va by activated protein C in the presence of heparin. European Journal of Biochemistry / Febs. 271: 2724-36. PMID 15206937 DOI: 10.1111/J.1432-1033.2004.04201.X |
0.718 |
|
| 2004 |
Sørensen KW, Nicolaes GA, Villoutreix BO, Yamazaki T, Tans G, Rosing J, Dahlbäck B. Functional properties of recombinant factor V mutated in a potential calcium-binding site. Biochemistry. 43: 5803-10. PMID 15134454 DOI: 10.1021/Bi0361362 |
0.731 |
|
| 2004 |
Castoldi E, Brugge JM, Nicolaes GA, Girelli D, Tans G, Rosing J. Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations. Blood. 103: 4173-9. PMID 14976057 DOI: 10.1182/Blood-2003-10-3578 |
0.718 |
|
| 2003 |
Nicolaes GA, Dahlbäck B. Congenital and acquired activated protein C resistance. Seminars in Vascular Medicine. 3: 33-46. PMID 15199491 DOI: 10.1055/S-2003-38331 |
0.571 |
|
| 2003 |
Nicolaes GA, Dahlbäck B. Activated protein C resistance (FV(Leiden)) and thrombosis: factor V mutations causing hypercoagulable states. Hematology/Oncology Clinics of North America. 17: 37-61, vi. PMID 12627662 DOI: 10.1016/S0889-8588(02)00097-7 |
0.572 |
|
| 2002 |
Govers-Riemslag JW, Castoldi E, Nicolaes GA, Tans G, Rosing J. Reduced factor V concentration and altered FV1/FV2 ratio do not fully explain R2-associated APC-resistance. Thrombosis and Haemostasis. 88: 444-9. PMID 12353074 DOI: 10.1055/S-0037-1613236 |
0.664 |
|
| 2002 |
Yamazaki T, Nicolaes GA, Sørensen KW, Dahlbäck B. Molecular basis of quantitative factor V deficiency associated with factor V R2 haplotype. Blood. 100: 2515-21. PMID 12239164 DOI: 10.1182/Blood.V100.7.2515 |
0.527 |
|
| 2002 |
Nicolaes GA, Dahlbäck B. Factor V and thrombotic disease: description of a janus-faced protein. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 530-8. PMID 11950687 DOI: 10.1161/01.Atv.0000012665.51263.B7 |
0.638 |
|
| 2001 |
Friedrich U, Nicolaes GA, Villoutreix BO, Dahlbäck B. Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va. The Journal of Biological Chemistry. 276: 23105-8. PMID 11309403 DOI: 10.1074/jbc.M103138200 |
0.549 |
|
| 2000 |
Evenäs P, García de Frutos P, Nicolaes GA, Dahlbäck B. The second laminin G-type domain of protein S is indispensable for expression of full cofactor activity in activated protein C-catalysed inactivation of factor Va and factor VIIIa. Thrombosis and Haemostasis. 84: 271-7. PMID 10959700 DOI: 10.1055/S-0037-1614007 |
0.579 |
|
| 2000 |
Nicolaes GA, Villoutreix BO, Dahlbäck B. Mutations in a potential phospholipid binding loop in the C2 domain of factor V affecting the assembly of the prothrombinase complex. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis. 11: 89-100. PMID 10691103 DOI: 10.1097/00001721-200001000-00010 |
0.551 |
|
| 1999 |
Nicolaes GA, Villoutreix BO, Dahlbäck B. Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation. Biochemistry. 38: 13584-91. PMID 10521265 DOI: 10.1021/Bi991165R |
0.503 |
|
| 1999 |
Curvers J, Thomassen MC, Nicolaes GA, Van Oerle R, Hamulyak K, Hemker HC, Tans G, Rosing J. Acquired APC resistance and oral contraceptives: differences between two functional tests. British Journal of Haematology. 105: 88-94. PMID 10233368 DOI: 10.1111/J.1365-2141.1999.01302.X |
0.736 |
|
| 1997 |
Rosing J, Tans G, Nicolaes GA, Thomassen MC, van Oerle R, van der Ploeg PM, Heijnen P, Hamulyak K, Hemker HC. Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second- and third-generation oral contraceptives. British Journal of Haematology. 97: 233-8. PMID 9136971 DOI: 10.1046/J.1365-2141.1997.192707.X |
0.707 |
|
| 1997 |
Hoekema L, Nicolaes GA, Hemker HC, Tans G, Rosing J. Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways. Biochemistry. 36: 3331-5. PMID 9116011 DOI: 10.1021/Bi9623284 |
0.752 |
|
| 1997 |
Nicolaes GA, Thomassen MC, Tans G, Rosing J, Hemker HC. Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals. Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis. 8: 28-38. PMID 9105635 DOI: 10.1097/00001721-199701000-00006 |
0.722 |
|
| 1996 |
Nicolaes GA, Thomassen MC, van Oerle R, Hamulyak K, Hemker HC, Tans G, Rosing J. A prothrombinase-based assay for detection of resistance to activated protein C. Thrombosis and Haemostasis. 76: 404-10. PMID 8883278 DOI: 10.1055/S-0038-1650591 |
0.749 |
|
| 1993 |
Lugtigheid RB, Nicolaes GA, Veldhuizen EJ, Slotboom AJ, Verheij HM, De Haas GH. Acylation of porcine pancreatic phospholipase A2 influences penetration and substrate head-group binding, depending on the position of the acylated lysine in the enzyme molecule. European Journal of Biochemistry / Febs. 216: 519-25. PMID 8375390 DOI: 10.1111/J.1432-1033.1993.Tb18170.X |
0.57 |
|
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