Jonathan P. Rast - Publications

Affiliations: 
Medical Biophysics University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology, Genetics

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Das S, Boehm T, Holland SJ, Rast JP, Fontenla-Iglesias F, Morimoto R, Valadez JG, Heimroth RD, Hirano M, Cooper MD. Evolution of two distinct variable lymphocyte receptors in lampreys: VLRD and VLRE. Cell Reports. 42: 112933. PMID 37542721 DOI: 10.1016/j.celrep.2023.112933  0.367
2021 Das S, Rast JP, Li J, Kadota M, Donald JA, Kuraku S, Hirano M, Cooper MD. Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34880135 DOI: 10.1073/pnas.2116522118  0.427
2019 Schuh NW, Carrier TJ, Schrankel CS, Reitzel AM, Heyland A, Rast JP. Bacterial Exposure Mediates Developmental Plasticity and Resistance to Lethal Infection in Purple Sea Urchin Larvae. Frontiers in Immunology. 10: 3014. PMID 31993052 DOI: 10.3389/Fimmu.2019.03014  0.37
2019 Das S, Sutoh Y, Cancro MP, Rast JP, Han Q, Bommakanti G, Cooper MD, Hirano M. Ancient -like Genes Herald B Cell Regulation in Lampreys. Journal of Immunology (Baltimore, Md. : 1950). PMID 31666307 DOI: 10.4049/Jimmunol.1900026  0.416
2019 Buckley KM, Rast JP. Immune activity at the gut epithelium in the larval sea urchin. Cell and Tissue Research. PMID 31463705 DOI: 10.1007/S00441-019-03095-7  0.487
2019 Buckley KM, Schuh NW, Heyland A, Rast JP. Analysis of immune response in the sea urchin larva. Methods in Cell Biology. 150: 333-355. PMID 30777183 DOI: 10.1016/Bs.Mcb.2018.10.009  0.458
2018 Heyland A, Schuh N, Rast J. Sea Urchin Larvae as a Model for Postembryonic Development. Results and Problems in Cell Differentiation. 65: 137-161. PMID 30083919 DOI: 10.1007/978-3-319-92486-1_8  0.364
2018 Liu MC, Liao WY, Buckley KM, Yang SY, Rast JP, Fugmann SD. AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates. Nature Communications. 9: 1948. PMID 29769532 DOI: 10.1038/S41467-018-04273-X  0.473
2017 Buckley KM, Rast JP. An Organismal Model for Gene Regulatory Networks in the Gut-Associated Immune Response. Frontiers in Immunology. 8: 1297. PMID 29109720 DOI: 10.3389/Fimmu.2017.01297  0.488
2017 Buckley KM, Dong P, Cameron RA, Rast JP. Bacterial artificial chromosomes as recombinant reporter constructs to investigate gene expression and regulation in echinoderms. Briefings in Functional Genomics. PMID 29045542 DOI: 10.1093/Bfgp/Elx031  0.413
2017 Ho EC, Buckley KM, Schrankel CS, Schuh NW, Hibino T, Solek CM, Bae K, Wang G, Rast JP. Perturbation of gut bacteria induces a coordinated cellular immune response in the purple sea urchin larva. Immunology and Cell Biology. 95: 647. PMID 28785056 DOI: 10.1038/icb.2017.40  0.767
2017 Adema CM, Hillier LW, Jones CS, Loker ES, Knight M, Minx P, Oliveira G, Raghavan N, Shedlock A, do Amaral LR, Arican-Goktas HD, Assis JG, Baba EH, Baron OL, Bayne CJ, ... ... Rast JP, et al. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nature Communications. 8: 15451. PMID 28508897 DOI: 10.1038/Ncomms15451  0.37
2017 Buckley KM, Ho ECH, Hibino T, Schrankel CS, Schuh NW, Wang G, Rast JP. IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva. Elife. 6. PMID 28447937 DOI: 10.7554/Elife.23481  0.331
2016 Schrankel CS, Solek CM, Buckley KM, Anderson MK, Rast JP. A conserved alternative form of the purple sea urchin HEB/E2-2/E2A transcription factor mediates a switch in E-protein regulatory state in differentiating immune cells. Developmental Biology. PMID 27265865 DOI: 10.1016/J.Ydbio.2016.05.034  0.759
2016 Ho EC, Buckley KM, Schrankel CS, Schuh NW, Hibino T, Solek CM, Bae K, Wang G, Rast JP. Perturbation of gut bacteria induces a coordinated cellular immune response in the purple sea urchin larva. Immunology and Cell Biology. PMID 27192936 DOI: 10.1038/Icb.2016.51  0.804
2015 Buckley KM, Rast JP. Diversity of animal immune receptors and the origins of recognition complexity in the deuterostomes. Developmental and Comparative Immunology. 49: 179-89. PMID 25450907 DOI: 10.1016/J.Dci.2014.10.013  0.483
2014 Moroz LL, Kocot KM, Citarella MR, Dosung S, Norekian TP, Povolotskaya IS, Grigorenko AP, Dailey C, Berezikov E, Buckley KM, Ptitsyn A, Reshetov D, Mukherjee K, Moroz TP, Bobkova Y, ... ... Rast JP, et al. The ctenophore genome and the evolutionary origins of neural systems. Nature. 510: 109-14. PMID 24847885 DOI: 10.1038/Nature13400  0.453
2013 Solek CM, Oliveri P, Loza-Coll M, Schrankel CS, Ho EC, Wang G, Rast JP. An ancient role for Gata-1/2/3 and Scl transcription factor homologs in the development of immunocytes. Developmental Biology. 382: 280-92. PMID 23792116 DOI: 10.1016/J.Ydbio.2013.06.019  0.804
2013 Rast JP, Buckley KM. Lamprey immunity is far from primitive. Proceedings of the National Academy of Sciences of the United States of America. 110: 5746-7. PMID 23553834 DOI: 10.1073/Pnas.1303541110  0.497
2013 Smith JJ, Kuraku S, Holt C, Sauka-Spengler T, Jiang N, Campbell MS, Yandell MD, Manousaki T, Meyer A, Bloom OE, Morgan JR, Buxbaum JD, Sachidanandam R, Sims C, Garruss AS, ... ... Rast JP, et al. Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nature Genetics. 45: 415-21, 421e1-2. PMID 23435085 DOI: 10.1038/Ng.2568  0.725
2012 Buckley KM, Rast JP. Dynamic evolution of toll-like receptor multigene families in echinoderms. Frontiers in Immunology. 3: 136. PMID 22679446 DOI: 10.3389/Fimmu.2012.00136  0.497
2011 Buckley KM, Rast JP. Characterizing immune receptors from new genome sequences. Methods in Molecular Biology (Clifton, N.J.). 748: 273-98. PMID 21701981 DOI: 10.1007/978-1-61779-139-0_19  0.491
2010 Smith LC, Ghosh J, Buckley KM, Clow LA, Dheilly NM, Haug T, Henson JH, Li C, Lun CM, Majeske AJ, Matranga V, Nair SV, Rast JP, Raftos DA, Roth M, et al. Echinoderm immunity. Advances in Experimental Medicine and Biology. 708: 260-301. PMID 21528703 DOI: 10.1007/978-1-4419-8059-5-14  0.408
2010 Litman GW, Rast JP, Fugmann SD. The origins of vertebrate adaptive immunity. Nature Reviews. Immunology. 10: 543-53. PMID 20651744 DOI: 10.1038/Nri2807  0.627
2010 Stevens ME, Dhillon J, Miller CA, Messier-Solek C, Majeske AJ, Zuelke D, Rast JP, Smith LC. SpTie1/2 is expressed in coelomocytes, axial organ and embryos of the sea urchin Strongylocentrotus purpuratus, and is an orthologue of vertebrate Tie1 and Tie2. Developmental and Comparative Immunology. 34: 884-95. PMID 20363251 DOI: 10.1016/J.Dci.2010.03.010  0.449
2010 Rast J, Litman G. Evolution of innate and adaptive immune recognition structures Seminars in Immunology. 22: 1-2. PMID 20138544 DOI: 10.1016/J.Smim.2010.01.001  0.592
2010 Messier-Solek C, Buckley KM, Rast JP. Highly diversified innate receptor systems and new forms of animal immunity. Seminars in Immunology. 22: 39-47. PMID 20022762 DOI: 10.1016/J.Smim.2009.11.007  0.45
2010 Ghosh J, Buckley KM, Nair SV, Raftos DA, Miller C, Majeske AJ, Hibino T, Rast JP, Roth M, Smith LC. Sp185/333: a novel family of genes and proteins involved in the purple sea urchin immune response. Developmental and Comparative Immunology. 34: 235-45. PMID 19887082 DOI: 10.1016/J.Dci.2009.10.008  0.496
2009 Anderson MK, Rast JP. Universal rules of immunity. Immunology and Cell Biology. 87: 507-9. PMID 19668259 DOI: 10.1038/Icb.2009.54  0.675
2008 Rast JP, Messier-Solek C. Marine invertebrate genome sequences and our evolving understanding of animal immunity. The Biological Bulletin. 214: 274-83. PMID 18574104 DOI: 10.2307/25470669  0.475
2008 Cameron RA, Rast JP. Biological bulletin virtual symposium: genomics of large marine metazoans. The Biological Bulletin. 214: 203-4. PMID 18574098 DOI: 10.1086/Bblv214N3P203  0.347
2008 Holland LZ, Albalat R, Azumi K, Benito-Gutiérrez E, Blow MJ, Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ, Ferrier DE, Garcia-Fernàndez J, Gibson-Brown JJ, Gissi C, Godzik A, ... ... Rast JP, et al. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Research. 18: 1100-11. PMID 18562680 DOI: 10.1101/Gr.073676.107  0.796
2008 Holland LZ, Albalat R, Azumi K, Benito-Gutiérrez E, Blow MJ, Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ, Ferrier DEK, Garcia-Fernàndez J, Gibson-Brown JJ, Gissi C, Godzik A, ... ... Rast JP, et al. The amphioxus genome illuminates vertebrate origins and cephalochordate biology (Genome Research (2008) 18, (1100-1111)) Genome Research. 18: 1380.  0.476
2007 Litman GW, Dishaw LJ, Cannon JP, Haire RN, Rast JP. Alternative mechanisms of immune receptor diversity. Current Opinion in Immunology. 19: 526-34. PMID 17703932 DOI: 10.1016/J.Coi.2007.07.001  0.779
2006 Rast JP, Smith LC, Loza-Coll M, Hibino T, Litman GW. Genomic insights into the immune system of the sea urchin. Science (New York, N.Y.). 314: 952-6. PMID 17095692 DOI: 10.1126/Science.1134301  0.683
2006 Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, ... ... Rast JP, et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science (New York, N.Y.). 314: 941-52. PMID 17095691 DOI: 10.1126/Science.1133609  0.677
2006 Hibino T, Loza-Coll M, Messier C, Majeske AJ, Cohen AH, Terwilliger DP, Buckley KM, Brockton V, Nair SV, Berney K, Fugmann SD, Anderson MK, Pancer Z, Cameron RA, Smith LC, ... Rast JP, et al. The immune gene repertoire encoded in the purple sea urchin genome. Developmental Biology. 300: 349-65. PMID 17027739 DOI: 10.1016/J.Ydbio.2006.08.065  0.769
2006 Fugmann SD, Messier C, Novack LA, Cameron RA, Rast JP. An ancient evolutionary origin of the Rag1/2 gene locus. Proceedings of the National Academy of Sciences of the United States of America. 103: 3728-33. PMID 16505374 DOI: 10.1073/Pnas.0509720103  0.527
2006 Cameron RA, Rowen L, Nesbitt R, Bloom S, Rast JP, Berney K, Arenas-Mena C, Martinez P, Lucas S, Richardson PM, Davidson EH, Peterson KJ, Hood L. Unusual gene order and organization of the sea urchin hox cluster. Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution. 306: 45-58. PMID 16116652 DOI: 10.1002/Jez.B.21070  0.42
2005 Amemiya CT, Miyake T, Rast JP. Echinoderms. Current Biology : Cb. 15: R944-6. PMID 16332519 DOI: 10.1016/j.cub.2005.11.026  0.67
2005 Litman GW, Cannon JP, Rast JP. New insights into alternative mechanisms of immune receptor diversification. Advances in Immunology. 87: 209-36. PMID 16102575 DOI: 10.1016/S0065-2776(05)87006-3  0.655
2004 Cameron RA, Rast JP, Brown CT. Genomic resources for the study of sea urchin development. Methods in Cell Biology. 74: 733-57. PMID 15575629 DOI: 10.1016/S0091-679X(04)74030-3  0.349
2004 Eason DD, Cannon JP, Haire RN, Rast JP, Ostrov DA, Litman GW. Mechanisms of antigen receptor evolution. Seminars in Immunology. 16: 215-26. PMID 15522620 DOI: 10.1016/J.Smim.2004.08.001  0.674
2004 Cannon JP, Haire RN, Rast JP, Litman GW. The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms. Immunological Reviews. 200: 12-22. PMID 15242392 DOI: 10.1111/J.0105-2896.2004.00166.X  0.692
2004 Minokawa T, Rast JP, Arenas-Mena C, Franco CB, Davidson EH. Expression patterns of four different regulatory genes that function during sea urchin development. Gene Expression Patterns : Gep. 4: 449-56. PMID 15183312 DOI: 10.1016/J.Modgep.2004.01.009  0.375
2003 Calestani C, Rast JP, Davidson EH. Isolation of pigment cell specific genes in the sea urchin embryo by differential macroarray screening. Development (Cambridge, England). 130: 4587-96. PMID 12925586 DOI: 10.1242/Dev.00647  0.459
2003 Rast JP. Development gene networks and evolution. Journal of Structural and Functional Genomics. 3: 225-34. PMID 12836701 DOI: 10.1007/978-94-010-0263-9_22  0.344
2003 Ota T, Rast JP, Litman GW, Amemiya CT. Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox. Proceedings of the National Academy of Sciences of the United States of America. 100: 2501-6. PMID 12606718 DOI: 10.1073/Pnas.0538029100  0.763
2002 Rast JP, Cameron RA, Poustka AJ, Davidson EH. brachyury Target genes in the early sea urchin embryo isolated by differential macroarray screening. Developmental Biology. 246: 191-208. PMID 12027442 DOI: 10.1006/Dbio.2002.0654  0.442
2002 Davidson EH, Rast JP, Oliveri P, Ransick A, Calestani C, Yuh CH, Minokawa T, Amore G, Hinman V, Arenas-Mena C, Otim O, Brown CT, Livi CB, Lee PY, Revilla R, et al. A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo. Developmental Biology. 246: 162-90. PMID 12027441 DOI: 10.1006/Dbio.2002.0635  0.391
2002 Ransick A, Rast JP, Minokawa T, Calestani C, Davidson EH. New early zygotic regulators expressed in endomesoderm of sea urchin embryos discovered by differential array hybridization. Developmental Biology. 246: 132-47. PMID 12027439 DOI: 10.1006/Dbio.2002.0607  0.416
2002 Davidson EH, Rast JP, Oliveri P, Ransick A, Calestani C, Yuh CH, Minokawa T, Amore G, Hinman V, Arenas-Mena C, Otim O, Brown CT, Livi CB, Lee PY, Revilla R, et al. A genomic regulatory network for development. Science (New York, N.Y.). 295: 1669-78. PMID 11872831 DOI: 10.1126/Science.1069883  0.354
2000 Rast JP, Amore G, Calestani C, Livi CB, Ransick A, Davidson EH. Recovery of developmentally defined gene sets from high-density cDNA macroarrays. Developmental Biology. 228: 270-86. PMID 11112329 DOI: 10.1006/Dbio.2000.9941  0.403
2000 Haire RN, Rast JP, Litman RT, Litman GW. Characterization of three isotypes of immunoglobulin light chains and T-cell antigen receptor alpha in zebrafish. Immunogenetics. 51: 915-23. PMID 11003385 DOI: 10.1007/S002510000229  0.662
2000 Cameron RA, Mahairas G, Rast JP, Martinez P, Biondi TR, Swartzell S, Wallace JC, Poustka AJ, Livingston BT, Wray GA, Ettensohn CA, Lehrach H, Britten RJ, Davidson EH, Hood L. A sea urchin genome project: sequence scan, virtual map, and additional resources. Proceedings of the National Academy of Sciences of the United States of America. 97: 9514-8. PMID 10920195 DOI: 10.1073/Pnas.160261897  0.412
2000 Haire RN, Miracle AL, Rast JP, Litman GW. Members of the Ikaros gene family are present in early representative vertebrates. Journal of Immunology (Baltimore, Md. : 1950). 165: 306-12. PMID 10861066 DOI: 10.4049/Jimmunol.165.1.306  0.78
2000 Rast JP, Pancer Z, Davidson EH. New approaches towards an understanding of deuterostome immunity. Current Topics in Microbiology and Immunology. 248: 3-16. PMID 10793471 DOI: 10.1007/978-3-642-59674-2_1  0.507
1999 Strong SJ, Mueller MG, Litman RT, Hawke NA, Haire RN, Miracle AL, Rast JP, Amemiya CT, Litman GW. A novel multigene family encodes diversified variable regions. Proceedings of the National Academy of Sciences of the United States of America. 96: 15080-5. PMID 10611341 DOI: 10.1073/Pnas.96.26.15080  0.779
1999 Pancer Z, Rast JP, Davidson EH. Origins of immunity: transcription factors and homologues of effector genes of the vertebrate immune system expressed in sea urchin coelomocytes. Immunogenetics. 49: 773-86. PMID 10398804 DOI: 10.1007/S002510050551  0.543
1999 Litman GW, Anderson MK, Rast JP. Evolution of antigen binding receptors. Annual Review of Immunology. 17: 109-47. PMID 10358755 DOI: 10.1146/Annurev.Immunol.17.1.109  0.688
1999 Martinez P, Rast JP, Arenas-Mena C, Davidson EH. Organization of an echinoderm Hox gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 96: 1469-74. PMID 9990047 DOI: 10.1073/Pnas.96.4.1469  0.413
1999 Anderson MK, Strong SJ, Litman RT, Luer CA, Amemiya CT, Rast JP, Litman GW. A long form of the skate IgX gene exhibits a striking resemblance to the new shark IgW and IgNARC genes. Immunogenetics. 49: 56-67. PMID 9811969 DOI: 10.1007/S002510050463  0.766
1998 Rast JP, Litman GW. Towards understanding the evolutionary origins and early diversification of rearranging antigen receptors. Immunological Reviews. 166: 79-86. PMID 9914904 DOI: 10.1111/J.1600-065X.1998.Tb01254.X  0.653
1998 Rast JP, Amemiya CT, Litman RT, Strong SJ, Litman GW. Distinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishes. Immunogenetics. 47: 234-45. PMID 9435342 DOI: 10.1007/S002510050353  0.616
1998 Rast JP, Amemiya CT, Litman RT, Strong SJ, Litman GW. Correction: Distinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishes (Immunogenetics (1998) 47 (234-245)) Immunogenetics. 47: 415. DOI: 10.1007/s002510050378  0.485
1997 Rast JP, Anderson MK, Strong SJ, Luer C, Litman RT, Litman GW. alpha, beta, gamma, and delta T cell antigen receptor genes arose early in vertebrate phylogeny. Immunity. 6: 1-11. PMID 9052832 DOI: 10.1016/S1074-7613(00)80237-X  0.749
1997 Ota T, Rast JP, Litman GW, Amemiya CT. J6 3:30 Lungfish immunoglobulins and their evolutionary implications Developmental & Comparative Immunology. 21: 159. DOI: 10.1016/S0145-305X(97)88639-9  0.543
1996 Six A, Rast JP, McCormack WT, Dunon D, Courtois D, Li Y, Chen CH, Cooper MD. Characterization of avian T-cell receptor gamma genes. Proceedings of the National Academy of Sciences of the United States of America. 93: 15329-34. PMID 8986811 DOI: 10.1073/Pnas.93.26.15329  0.4
1996 Litman GW, Rast JP. The organization and structure of immunoglobulin and T-cell receptor genes in the most phylogenetically distant jawed vertebrates: evolutionary implications. Research in Immunology. 147: 226-33. PMID 8844900 DOI: 10.1016/0923-2494(96)87225-7  0.617
1996 Hawke NA, Rast JP, Litman GW. Extensive diversity of transcribed TCR-beta in phylogenetically primitive vertebrate. Journal of Immunology (Baltimore, Md. : 1950). 156: 2458-64. PMID 8786305  0.789
1996 Haire RN, Ota T, Rast JP, Litman RT, Chan FY, Zon LI, Litman GW. A third Ig light chain gene isotype in Xenopus laevis consists of six distinct VL families and is related to mammalian lambda genes. Journal of Immunology (Baltimore, Md. : 1950). 157: 1544-50. PMID 8759737  0.586
1995 Rast JP, Haire RN, Litman RT, Pross S, Litman GW. Identification and characterization of T-cell antigen receptor-related genes in phylogenetically diverse vertebrate species. Immunogenetics. 42: 204-12. PMID 7642232 DOI: 10.1007/Bf00191226  0.65
1994 Rast JP, Anderson MK, Ota T, Litman RT, Margittai M, Shamblott MJ, Litman GW. Immunoglobulin light chain class multiplicity and alternative organizational forms in early vertebrate phylogeny. Immunogenetics. 40: 83-99. PMID 8026868 DOI: 10.1007/Bf00188170  0.719
1994 Rast JP, Litman GW. T-cell receptor gene homologs are present in the most primitive jawed vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 91: 9248-52. PMID 7937749 DOI: 10.1073/Pnas.91.20.9248  0.661
1994 Anderson M, Amemiya C, Luer C, Litman R, Rast J, Niimura Y, Litman G. Complete genomic sequence and patterns of transcription of a member of an unusual family of closely related, chromosomally dispersed Ig gene clusters in Raja. International Immunology. 6: 1661-70. PMID 7865459 DOI: 10.1093/Intimm/6.11.1661  0.772
1993 Litman GW, Rast JP, Shamblott MJ, Haire RN, Hulst M, Roess W, Litman RT, Hinds-Frey KR, Zilch A, Amemiya CT. Phylogenetic diversification of immunoglobulin genes and the antibody repertoire. Molecular Biology and Evolution. 10: 60-72. PMID 8450761 DOI: 10.1093/Oxfordjournals.Molbev.A040000  0.652
1993 Amemiya CT, Ohta Y, Litman RT, Rast JP, Haire RN, Litman GW. VH gene organization in a relict species, the coelacanth Latimeria chalumnae: evolutionary implications. Proceedings of the National Academy of Sciences of the United States of America. 90: 6661-5. PMID 8341683 DOI: 10.1073/Pnas.90.14.6661  0.563
1992 Litman GW, Haire RN, Hinds KR, Amemiya CT, Rast JP, Hulst M. Evolutionary development of the B-cell repertoire. Annals of the New York Academy of Sciences. 651: 360-8. PMID 1599131 DOI: 10.1111/J.1749-6632.1992.Tb24636.X  0.524
Show low-probability matches.