Loren A. Zech, M.D. - Publications

Affiliations: 
Laboratory of Mathematical Biology National Institutes of Health, NCI 
Area:
kinetic modeling, lipoprotein metabolism

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Year Citation  Score
2009 Sodhi SS, Zech LA, Batura V, Kulasekhar S. Diaphragmatic hernia with strangulated loop of bowel presenting after colonoscopy: case report. International Archives of Medicine. 2: 38. PMID 20003353 DOI: 10.1186/1755-7682-2-38  0.68
2008 Zech LA, Hoeg JM. Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia. Lipids in Health and Disease. 7: 7. PMID 18331643 DOI: 10.1186/1476-511X-7-7  0.68
2004 Ikewaki K, Cain W, Thomas F, Shamburek R, Zech LA, Usher D, Brewer HB, Rader DJ. Abnormal in vivo metabolism of apoB-containing lipoproteins in human apoE deficiency. Journal of Lipid Research. 45: 1302-11. PMID 15102883 DOI: 10.1194/jlr.M400020-JLR200  0.68
2003 Lewis KC, Hochadel JF, Zech LA. A systems modeling approach to the study of retinoid function: implications for evaluation of retinoids in cancer chemoprevention and/or chemotherapy. Advances in Experimental Medicine and Biology. 537: 301-16. PMID 14995044  0.68
2002 Ikewaki K, Zech LA, Brewer HB, Rader DJ. Comparative in vivo metabolism of apolipoproteins E2 and E4 in heterozygous apoE2/4 subjects. The Journal of Laboratory and Clinical Medicine. 140: 369-74. PMID 12434139 DOI: 10.1067/mlc.2002.129066  0.68
1998 Schmidt HH, Gregg RE, Tietge UJ, Beisiegel U, Zech LA, Brewer HB, Manns MP, Bojanovski D. Upregulated synthesis of both apolipoprotein A-I and apolipoprotein B in familial hyperalphalipoproteinemia and hyperbetalipoproteinemia. Metabolism: Clinical and Experimental. 47: 1160-6. PMID 9751249 DOI: 10.1016/S0026-0495(98)90294-3  0.68
1998 Schmidt HH, Stuhrmann M, Shamburek R, Schewe CK, Ebhardt M, Zech LA, Büttner C, Wendt M, Beisiegel U, Brewer HB, Manns MP. Delayed low density lipoprotein (LDL) catabolism despite a functional intact LDL-apolipoprotein B particle and LDL-receptor in a subject with clinical homozygous familial hypercholesterolemia. The Journal of Clinical Endocrinology and Metabolism. 83: 2167-74. PMID 9626156 DOI: 10.1210/jcem.83.6.4840  0.68
1998 Fisher WR, Zech LA, Stacpoole PW. Apolipoprotein B metabolism in hypertriglyceridemic diabetic patients administered either a fish oil- or vegetable oil-enriched diet. Journal of Lipid Research. 39: 388-401. PMID 9507999  0.68
1997 Shamburek RD, Pentchev PG, Zech LA, Blanchette-Mackie J, Carstea ED, VandenBroek JM, Cooper PS, Neufeld EB, Phair RD, Brewer HB, Brady RO, Schwartz CC. Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation. Journal of Lipid Research. 38: 2422-35. PMID 9458266  0.68
1997 Venkatakrishnan V, Fisher WR, Zech LA. Determination of the radiation dose from administered apolipoprotein tracers in humans. Metabolism: Clinical and Experimental. 46: 1231-9. PMID 9322813 DOI: 10.1016/S0026-0495(97)90223-7  0.68
1997 Schmidt HH, Gregg RE, Shamburek R, Brewer BH, Zech LA. Erdheim-Chester disease: low low-density lipoprotein levels due to rapid catabolism. Metabolism: Clinical and Experimental. 46: 1215-9. PMID 9322810 DOI: 10.1016/S0026-0495(97)90220-1  0.68
1997 Schaefer JR, Scharnagl H, Baumstark MW, Schweer H, Zech LA, Seyberth H, Winkler K, Steinmetz A, März W. Homozygous familial defective apolipoprotein B-100. Enhanced removal of apolipoprotein E-containing VLDLs and decreased production of LDLs. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 348-53. PMID 9081691  0.68
1997 Fisher WR, Venkatakrishnan V, Fisher ES, Stacpoole PW, Zech LA. The 3H-leucine tracer: its use in kinetic studies of plasma lipoproteins. Metabolism: Clinical and Experimental. 46: 333-42. PMID 9054478 DOI: 10.1016/S0026-0495(97)90262-6  0.68
1997 Patterson B, Zech L, Veillon C, Levander O. Application of a model of human selenium metabolism to cancer chemoprevention trials Faseb Journal. 11: A359.  0.36
1996 Ikewaki K, Zech LA, Brewer HB, Rader DJ. ApoA-II kinetics in humans using endogenous labeling with stable isotopes: slower turnover of apoA-II compared with the exogenous radiotracer method. Journal of Lipid Research. 37: 399-407. PMID 9026537  0.68
1996 Shamburek RD, Zech LA, Cooper PS, Vandenbroek JM, Schwartz CC. Disappearance of two major phosphatidylcholines from plasma is predominantly via LCAT and hepatic lipase. The American Journal of Physiology. 271: E1073-82. PMID 8997228  0.68
1996 Lewis KC, Zech LA, Phang JM. Effects of chronic administration of N-(4-hydroxyphenyl)retinamide (4-HPR) in rats on vitamin A metabolism in the eye. European Journal of Cancer (Oxford, England : 1990). 32: 1803-8. PMID 8983293 DOI: 10.1016/0959-8049(96)00197-9  0.68
1996 Didolkar MS, Jackson AJ, Lesko LJ, Fitzpatrick JL, Buda BS, Johnston GS, Zech LA. Pharmacokinetics of dacarbazine in the regional perfusion of extremities with melanoma. Journal of Surgical Oncology. 63: 148-58. PMID 8944058 DOI: 10.1002/(SICI)1096-9098(199611)63:3<148::AID-JSO4>3.0.CO;2-D  0.68
1996 Hanes D, Zech LA, Murrell J, Benson MD. Metabolism of normal and Met30 transthyretin. Advances in Food and Nutrition Research. 40: 149-55. PMID 8858811 DOI: 10.1016/S1043-4526(08)60025-X  0.68
1996 Gabelli C, Bilato C, Martini S, Tennyson GE, Zech LA, Corsini A, Albanese M, Brewer HB, Crepaldi G, Baggio G. Homozygous familial hypobetalipoproteinemia. Increased LDL catabolism in hypobetalipoproteinemia due to a truncated apolipoprotein B species, apo B-87Padova. Arteriosclerosis, Thrombosis, and Vascular Biology. 16: 1189-96. PMID 8792774  0.68
1996 Brousseau ME, Santamarina-Fojo S, Zech LA, Bérard AM, Vaisman BL, Meyn SM, Powell D, Brewer HB, Hoeg JM. Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits. In vivo apolipoprotein A-I catabolism is delayed in a gene dose-dependent manner. The Journal of Clinical Investigation. 97: 1844-51. PMID 8621767 DOI: 10.1172/JCI118614  0.68
1996 Boston RC, McNabb T, Greif PC, Zech LA. Chapter 18 Essential Numerical Supports for Kinetic Modeling Software: Linear Integrators Advances in Food and Nutrition Research. 40: 281-303. DOI: 10.1016/S1043-4526(08)60035-2  0.68
1996 Novotny JA, Zech LA, Furr HC, Dueker SR, Clifford AJ. Chapter 2 Mathematical Modeling In Nutrition: Constructing A Physiologic Compartmental Model Of The Dynamics Of β-Carotene Metabolism Advances in Food and Nutrition Research. 40: 25-54. DOI: 10.1016/S1043-4526(08)60019-4  0.68
1996 Lewis KC, Zech LA, Phang JM. Effects of chronic administration of AT-(4-hydroxyphenyl)retinamide (4-HPR) in rats on vitamin a metabolism in the eye European Journal of Cancer Part A. 32: 1797-1802.  0.68
1995 Schmidt HH, Remaley AT, Stonik JA, Ronan R, Wellmann A, Thomas F, Zech LA, Brewer HB, Hoeg JM. Carboxyl-terminal domain truncation alters apolipoprotein A-I in vivo catabolism. The Journal of Biological Chemistry. 270: 5469-75. PMID 7890663 DOI: 10.1074/jbc.270.10.5469  0.68
1995 Rader DJ, Mann WA, Cain W, Kraft HG, Usher D, Zech LA, Hoeg JM, Davignon J, Lupien P, Grossman M. The low density lipoprotein receptor is not required for normal catabolism of Lp(a) in humans. The Journal of Clinical Investigation. 95: 1403-8. PMID 7883987 DOI: 10.1172/JCI117794  0.68
1995 Ikewaki K, Zech LA, Kindt M, Brewer HB, Rader DJ. Apolipoprotein A-II production rate is a major factor regulating the distribution of apolipoprotein A-I among HDL subclasses LpA-I and LpA-I:A-II in normolipidemic humans. Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 306-12. PMID 7749839  0.68
1995 Ikewaki K, Nishiwaki M, Sakamoto T, Ishikawa T, Fairwell T, Zech LA, Nagano M, Nakamura H, Brewer HB, Rader DJ. Increased catabolic rate of low density lipoproteins in humans with cholesteryl ester transfer protein deficiency. The Journal of Clinical Investigation. 96: 1573-81. PMID 7657828 DOI: 10.1172/JCI118196  0.68
1995 Mann WA, Lohse P, Gregg RE, Ronan R, Hoeg JM, Zech LA, Brewer HB. Dominant expression of type III hyperlipoproteinemia. Pathophysiological insights derived from the structural and kinetic characteristics of ApoE-1 (Lys146-->Glu). The Journal of Clinical Investigation. 96: 1100-7. PMID 7635945 DOI: 10.1172/JCI118096  0.68
1995 Novotny JA, Dueker SR, Zech LA, Clifford AJ. Compartmental analysis of the dynamics of beta-carotene metabolism in an adult volunteer. Journal of Lipid Research. 36: 1825-38. PMID 7595103  0.68
1995 Fisher WR, Venkatakrishnan V, Zech LA, Hall CM, Kilgore LL, Stacpoole PW, Diffenderfer MR, Friday KE, Sumner AE, Marsh JB. Kinetic evidence for both a fast and a slow secretory pathway for apolipoprotein A-I in humans. Journal of Lipid Research. 36: 1618-28. PMID 7595084  0.68
1994 Rader DJ, Cain W, Ikewaki K, Talley G, Zech LA, Usher D, Brewer HB. The inverse association of plasma lipoprotein(a) concentrations with apolipoprotein(a) isoform size is not due to differences in Lp(a) catabolism but to differences in production rate. The Journal of Clinical Investigation. 93: 2758-63. PMID 8201014 DOI: 10.1172/JCI117292  0.68
1994 Fisher WR, Zech LA, Stacpoole PW. ApoB metabolism in familial hypercholesterolemia. Inconsistencies with the LDL receptor paradigm. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology / American Heart Association. 14: 501-10. PMID 8148348  0.68
1994 Lewis KC, Zech LA, Phang JM. Effects of N-(4-hydroxyphenyl)retinamide supplementation on vitamin A metabolism. Cancer Research. 54: 4112-7. PMID 8033144  0.68
1994 Ikewaki K, Rader DJ, Zech LA, Brewer HB. In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism. Journal of Lipid Research. 35: 1809-19. PMID 7852858  0.68
1993 Roma P, Gregg RE, Meng MS, Ronan R, Zech LA, Franceschini G, Sirtori CR, Brewer HB. In vivo metabolism of a mutant form of apolipoprotein A-I, apo A-IMilano, associated with familial hypoalphalipoproteinemia. The Journal of Clinical Investigation. 91: 1445-52. PMID 8473493 DOI: 10.1172/JCI116349  0.68
1993 Schwartz CC, Zech LA, VandenBroek JM, Cooper PS. Cholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate. The Journal of Clinical Investigation. 91: 923-38. PMID 8450070 DOI: 10.1172/JCI116314  0.68
1993 Klein HG, Lohse P, Duverger N, Albers JJ, Rader DJ, Zech LA, Santamarina-Fojo S, Brewer HB. Two different allelic mutations in the lecithin:cholesterol acyltransferase (LCAT) gene resulting in classic LCAT deficiency: LCAT (tyr83-->stop) and LCAT (tyr156-->asn). Journal of Lipid Research. 34: 49-58. PMID 8445342  0.68
1993 Rader DJ, Cain W, Zech LA, Usher D, Brewer HB. Variation in lipoprotein(a) concentrations among individuals with the same apolipoprotein (a) isoform is determined by the rate of lipoprotein(a) production. The Journal of Clinical Investigation. 91: 443-7. PMID 8432853 DOI: 10.1172/JCI116221  0.68
1993 Ikewaki K, Rader DJ, Sakamoto T, Nishiwaki M, Wakimoto N, Schaefer JR, Ishikawa T, Fairwell T, Zech LA, Nakamura H. Delayed catabolism of high density lipoprotein apolipoproteins A-I and A-II in human cholesteryl ester transfer protein deficiency. The Journal of Clinical Investigation. 92: 1650-8. PMID 8408618 DOI: 10.1172/JCI116750  0.68
1993 Rader DJ, Schäfer J, Lohse P, Verges B, Kindt M, Zech LA, Steinmetz A, Brewer HB. Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein. The Journal of Clinical Investigation. 92: 1009-17. PMID 8349786 DOI: 10.1172/JCI116606  0.68
1993 Ikewaki K, Rader DJ, Schaefer JR, Fairwell T, Zech LA, Brewer HB. Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods. Journal of Lipid Research. 34: 2207-15. PMID 8301239  0.68
1993 Rader DJ, Schaefer JR, Lohse P, Ikewaki K, Thomas F, Harris WA, Zech LA, Dujovne CA, Brewer HB. Increased production of apolipoprotein A-I associated with elevated plasma levels of high-density lipoproteins, apolipoprotein A-I, and lipoprotein A-I in a patient with familial hyperalphalipoproteinemia. Metabolism: Clinical and Experimental. 42: 1429-34. PMID 8231838 DOI: 10.1016/0026-0495(93)90194-S  0.68
1993 Patterson BH, Zech LA, Swanson CA, Levander OA. Kinetic modeling of selenium in humans using stable isotope tracers Journal of Trace Elements and Electrolytes in Health and Disease. 7: 117-120.  0.68
1992 Rader DJ, Gregg RE, Meng MS, Schaefer JR, Zech LA, Benson MD, Brewer HB. In vivo metabolism of a mutant apolipoprotein, apoA-IIowa, associated with hypoalphalipoproteinemia and hereditary systemic amyloidosis. Journal of Lipid Research. 33: 755-63. PMID 1619367  0.68
1992 Schaefer JR, Rader DJ, Ikewaki K, Fairwell T, Zech LA, Kindt MR, Davignon J, Gregg RE, Brewer HB. In vivo metabolism of apolipoprotein A-I in a patient with homozygous familial hypercholesterolemia. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology / American Heart Association. 12: 843-8. PMID 1616910  0.68
1992 Patterson BH, Zech LA. Development of a model for selenite metabolism in humans. The Journal of Nutrition. 122: 709-14. PMID 1542037  0.68
1991 Swanson CA, Patterson BH, Levander OA, Veillon C, Taylor PR, Helzlsouer K, McAdam PA, Zech LA. Human [74Se]selenomethionine metabolism: a kinetic model. The American Journal of Clinical Nutrition. 54: 917-26. PMID 1951166  0.68
1991 Jackson AJ, Zech LA. Easy and practical utilization of CONSAM for simulation, analysis, and optimization of complex dosing regimens. Journal of Pharmaceutical Sciences. 80: 317-20. PMID 1865330  0.68
1991 Zech LA, Rader DJ, Greif PC. Berman's simulation analysis and modeling. Advances in Experimental Medicine and Biology. 285: 188-99. PMID 1858549  0.68
1991 Rader DJ, Castro G, Zech LA, Fruchart JC, Brewer HB. In vivo metabolism of apolipoprotein A-I on high density lipoprotein particles LpA-I and LpA-I,A-II. Journal of Lipid Research. 32: 1849-59. PMID 1770304  0.68
1991 Stacpoole PW, von Bergmann K, Kilgore LL, Zech LA, Fisher WR. Nutritional regulation of cholesterol synthesis and apolipoprotein B kinetics: studies in patients with familial hypercholesterolemia and normal subjects treated with a high carbohydrate, low fat diet. Journal of Lipid Research. 32: 1837-48. PMID 1770303  0.68
1991 Fisher WR, Zech LA, Kilgore LL, Stacpoole PW. Metabolic pathways of apolipoprotein B in heterozygous familial hypercholesterolemia: studies with a [3H]leucine tracer. Journal of Lipid Research. 32: 1823-36. PMID 1770302  0.68
1990 Beltz WF, Kesäniemi YA, Miller NH, Fisher WR, Grundy SM, Zech LA. Studies on the metabolism of apolipoprotein B in hypertriglyceridemic subjects using simultaneous administration of tritiated leucine and radioiodinated very low density lipoprotein. Journal of Lipid Research. 31: 361-74. PMID 2341804  0.68
1990 Lewis KC, Green MH, Green JB, Zech LA. Retinol metabolism in rats with low vitamin A status: a compartmental model. Journal of Lipid Research. 31: 1535-48. PMID 2246607  0.68
1990 Murthy VN, Marzetta CA, Rudel LL, Zech LA, Foster DM. Hepatic apo B-100 lipoproteins and plasma LDL heterogeneity in African green monkeys. The American Journal of Physiology. 258: E1041-57. PMID 2193530  0.68
1990 Schaeffer JR, Rader DJ, Gregg RE, Fairwell T, Zech LA, Kindt MR, Benson MD, Brewer HB. In vivo protein metabolism utilizing stable isotopes and mass spectrometry: a new approach to the study of mutant proteins in humans. Transactions of the Association of American Physicians. 103: 187-94. PMID 2132530  0.68
1990 Roma P, Gregg RE, Bishop C, Ronan R, Zech LA, Meng MV, Glueck C, Vergani C, Giudici G, Brewer HB. Apolipoprotein A-I metabolism in subjects with a PstI restriction fragment length polymorphism of the apoA-I gene and familial hypoalphalipoproteinemia. Journal of Lipid Research. 31: 1753-60. PMID 1981893  0.68
1989 DiGiovanna JJ, Zech LA, Ruddel ME, Gantt G, Peck GL. Etretinate. Persistent serum levels after long-term therapy. Archives of Dermatology. 125: 246-51. PMID 2913962 DOI: 10.1001/archderm.1989.01670140098019  0.68
1989 Marzetta CA, Johnson FL, Zech LA, Foster DM, Rudel LL. Metabolic behavior of hepatic VLDL and plasma LDL apoB-100 in African green monkeys. Journal of Lipid Research. 30: 357-70. PMID 2723543  0.68
1989 Rosen SG, Linares OA, Sanfield JA, Zech LA, Lizzio VP, Halter JB. Epinephrine kinetics in humans: radiotracer methodology. The Journal of Clinical Endocrinology and Metabolism. 69: 753-61. PMID 2674185 DOI: 10.1210/jcem-69-4-753  0.68
1989 Foster DM, Boston RC, Jacquez JA, Zech L. A resource facility for kinetic analysis: modeling using the SAAM computer programs. Health Physics. 57: 457-66. PMID 2606705  0.6
1989 Patterson BH, Levander OA, Helzlsouer K, McAdam PA, Lewis SA, Taylor PR, Veillon C, Zech LA. Human selenite metabolism: a kinetic model. The American Journal of Physiology. 257: R556-67. PMID 2551194  0.68
1989 Foster DM, Boston RC, Zech LA. Kinetics of lipoprotein metabolism. Special considerations in modeling Ifac Proceedings Series. 327-332.  0.68
1989 Gregg RE, Roma P, Bojanovski D, Schaefer JR, Zech LA, Kindt MR, Meng MS, Ronan R, Franceschini G, Sirtori CR, Brewer HB. The kinetics of apolipoprotein A-I metabolism in humans with altered levels of high density lipoproteins Atherosclerosis Viii: Proceedings of the 8th International Symposium On Atherosclerosis. Ics817. 285-289.  0.68
1988 Linares OA, Zech LA, Jacquez JA, Rosen SG, Sanfield JA, Morrow LA, Supiano MA, Halter JB. Effect of sodium-restricted diet and posture on norepinephrine kinetics in humans. The American Journal of Physiology. 254: E222-30. PMID 3348372  0.68
1988 Rall CJ, Hoeg JM, Gregg RE, Law SW, Monge JC, Meng MS, Zech LA, Brewer HB. Enhanced apolipoprotein E production with normal hepatic mRNA levels in the Watanabe heritable hyperlipidemic rabbit. Arteriosclerosis (Dallas, Tex.). 8: 804-9. PMID 3196225  0.68
1988 Stacpoole PW, Alig J, Kilgore LL, Ayala CM, Herbert PN, Zech LA, Fisher WR. Lipodystrophic diabetes mellitus. Investigations of lipoprotein metabolism and the effects of omega-3 fatty acid administration in two patients. Metabolism: Clinical and Experimental. 37: 944-51. PMID 3050365 DOI: 10.1016/0026-0495(88)90151-5  0.68
1987 Redgrave TG, Zech LA. A kinetic model of chylomicron core lipid metabolism in rats: the effect of a single meal. Journal of Lipid Research. 28: 473-82. PMID 3598392  0.68
1987 Dreskin SC, Goldsmith PK, Strober W, Zech LA, Gallin JI. Metabolism of immunoglobulin E in patients with markedly elevated serum immunoglobulin E levels. The Journal of Clinical Investigation. 79: 1764-72. PMID 3584468 DOI: 10.1172/JCI113017  0.68
1987 Linares OA, Jacquez JA, Zech LA, Smith MJ, Sanfield JA, Morrow LA, Rosen SG, Halter JB. Norepinephrine metabolism in humans. Kinetic analysis and model. The Journal of Clinical Investigation. 80: 1332-41. PMID 3316275 DOI: 10.1172/JCI113210  0.68
1987 Bojanovski D, Gregg RE, Zech LA, Meng MS, Bishop C, Ronan R, Brewer HB. In vivo metabolism of proapolipoprotein A-I in Tangier disease. The Journal of Clinical Investigation. 80: 1742-7. PMID 3119665 DOI: 10.1172/JCI113266  0.68
1986 Schaefer EJ, Gregg RE, Ghiselli G, Forte TM, Ordovas JM, Zech LA, Brewer HB. Familial apolipoprotein E deficiency. The Journal of Clinical Investigation. 78: 1206-19. PMID 3771793 DOI: 10.1172/JCI112704  0.68
1986 Gregg RE, Zech LA, Schaefer EJ, Stark D, Wilson D, Brewer HB. Abnormal in vivo metabolism of apolipoprotein E4 in humans. The Journal of Clinical Investigation. 78: 815-21. PMID 3745440 DOI: 10.1172/JCI112645  0.68
1986 Patterson BW, Hansard SL, Ammerman CB, Henry PR, Zech LA, Fisher WR. Kinetic model of whole-body vanadium metabolism: studies in sheep. The American Journal of Physiology. 251: R325-32. PMID 3740315  0.68
1986 Gabelli C, Gregg RE, Zech LA, Manzato E, Brewer HB. Abnormal low density lipoprotein metabolism in apolipoprotein E deficiency. Journal of Lipid Research. 27: 326-33. PMID 3734629  0.68
1986 Zech LA, Boston RC, Foster DM. The methodology of compartmental modeling as applied to the investigation of lipoprotein metabolism. Methods in Enzymology. 129: 366-84. PMID 3724545  0.68
1986 Boston RC, Granek H, Sutton N, Weber K, Greif P, Zech L. The maintenance, distribution and development of biomedical computer software: an exercise in software engineering Computer Methods and Programs in Biomedicine. 22: 305-321. PMID 3637127 DOI: 10.1016/0169-2607(86)90007-6  0.6
1986 Hoeg JM, Maher MB, Zech LA, Bailey KR, Gregg RE, Lackner KJ, Fojo SS, Anchors MA, Bojanovski M, Sprecher DL. Effectiveness of mevinolin on plasma lipoprotein concentrations in type II hyperlipoproteinemia. The American Journal of Cardiology. 57: 933-9. PMID 3515897 DOI: 10.1016/0002-9149(86)90733-2  0.68
1985 Hoeg JM, Maher MB, Bailey KR, Zech LA, Gregg RE, Sprecher DL, Brewer HB. Effects of combination cholestyramine-neomycin treatment on plasma lipoprotein concentrations in type II hyperlipoproteinemia. The American Journal of Cardiology. 55: 1282-6. PMID 3887883 DOI: 10.1016/0002-9149(85)90489-8  0.68
1985 Wilson PW, Zech LA, Gregg RE, Schaefer EJ, Hoeg JM, Sprecher DL, Brewer HB. Estimation of VLDL cholesterol in hyperlipidemia. Clinica Chimica Acta; International Journal of Clinical Chemistry. 151: 285-91. PMID 3863729 DOI: 10.1016/0009-8981(85)90091-9  0.68
1985 Sprecher DL, Hoeg JM, Schaefer EJ, Zech LA, Gregg RE, Lakatos E, Brewer HB. The association of LDL receptor activity, LDL cholesterol level, and clinical course in homozygous familial hypercholesterolemia. Metabolism: Clinical and Experimental. 34: 294-9. PMID 3856094 DOI: 10.1016/0026-0495(85)90015-0  0.68
1984 Bieri JG, Hoeg JM, Schaefer EJ, Zech LA, Brewer HB. Vitamin A and vitamin E replacement in abetalipoproteinemia. Annals of Internal Medicine. 100: 238-9. PMID 6691669  0.68
1984 Gregg RE, Zech LA, Schaefer EJ, Brewer HB. Apolipoprotein E metabolism in normolipoproteinemic human subjects. Journal of Lipid Research. 25: 1167-76. PMID 6520540  0.68
1984 Osborne JC, Schaefer EJ, Powell GM, Lee NS, Zech LA. Molecular properties of radioiodinated apolipoprotein A-I. The Journal of Biological Chemistry. 259: 347-53. PMID 6423628  0.68
1984 Hoeg JM, Maher MB, Bou E, Zech LA, Bailey KR, Gregg RE, Sprecher DL, Susser JK, Pikus AM, Brewer HB. Normalization of plasma lipoprotein concentrations in patients with type II hyperlipoproteinemia by combined use of neomycin and niacin. Circulation. 70: 1004-11. PMID 6388897  0.68
1984 Hoeg JM, Schaefer EJ, Romano CA, Bou E, Pikus AM, Zech LA, Bailey KR, Gregg RE, Wilson PW, Sprecher DL. Neomycin and plasma lipoproteins in type II hyperlipoproteinemia. Clinical Pharmacology and Therapeutics. 36: 555-65. PMID 6383687  0.68
1984 Sprecher DL, Schaefer EJ, Kent KM, Gregg RE, Zech LA, Hoeg JM, McManus B, Roberts WC, Brewer HB. Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 patients. The American Journal of Cardiology. 54: 20-30. PMID 6331147 DOI: 10.1016/0002-9149(84)90298-4  0.68
1984 Zech LA. Lipid, lipoprotein, and apolipoprotein models: past, present, and future Mathematical Biosciences. 72: 407-414. DOI: 10.1016/0025-5564(84)90121-4  0.68
1983 Brewer HB, Zech LA, Gregg RE, Schwartz D, Schaefer EJ. NIH conference. Type III hyperlipoproteinemia: diagnosis, molecular defects, pathology, and treatment. Annals of Internal Medicine. 98: 623-40. PMID 6846977  0.68
1983 Schaefer EJ, Triche TJ, Zech LA, Stein LA, Kemeny MM, Brennan MF, Brewer HB. Massive omental reticuloendothelial cell lipid uptake in Tangier disease after splenectomy. The American Journal of Medicine. 75: 521-6. PMID 6614036 DOI: 10.1016/0002-9343(83)90359-5  0.68
1983 Schaefer EJ, Foster DM, Zech LA, Lindgren FT, Brewer HB, Levy RI. The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females. The Journal of Clinical Endocrinology and Metabolism. 57: 262-7. PMID 6408108 DOI: 10.1210/jcem-57-2-262  0.68
1983 Zech LA, Schaefer EJ, Bronzert TJ, Aamodt RL, Brewer HB. Metabolism of human apolipoproteins A-I and A-II: compartmental models. Journal of Lipid Research. 24: 60-71. PMID 6403641  0.68
1983 Zech LA, Gross EG, Peck GL, Brewer HB. Changes in plasma cholesterol and triglyceride levels after treatment with oral isotretinoin. A prospective study. Archives of Dermatology. 119: 987-93. PMID 6228196 DOI: 10.1001/archderm.1983.01650360033009  0.68
1983 Gregg RE, Zech LA, Brewer HB. Apolipoprotein E alleles in severe hypertriglyceridaemia. Lancet (London, England). 1: 353. PMID 6130351  0.68
1982 Schaefer EJ, Kay LL, Zech LA, Brewer HB. Tangier disease. High density lipoprotein deficiency due to defective metabolism of an abnormal apolipoprotein A-i (ApoA-ITangier). The Journal of Clinical Investigation. 70: 934-45. PMID 7130397  0.68
1982 Ghiselli G, Schaefer EJ, Zech LA, Gregg RE, Brewer HB. Increased prevalence of apolipoprotein E4 in type V hyperlipoproteinemia. The Journal of Clinical Investigation. 70: 474-7. PMID 7096573  0.68
1982 Schaefer EJ, Zech LA, Jenkins LL, Bronzert TJ, Rubalcaba EA, Lindgren FT, Aamodt RL, Brewer HB. Human apolipoprotein A-I and A-II metabolism. Journal of Lipid Research. 23: 850-62. PMID 6813411  0.68
1982 Ghiselli G, Gregg RE, Zech LA, Schaefer EJ, Brewer HB. Phenotype study of apolipoprotein E isoforms in hyperlipoproteinaemic patients. Lancet (London, England). 2: 405-7. PMID 6124804 DOI: 10.1016/S0140-6736(82)90437-8  0.68
1982 Gross EG, Zech LA, McClean SW. Differential binding of synthetic retinoids to beta-lipoproteins Clinical Research. 30: 587A.  0.68
1981 Gregg RE, Zech LA, Schaefer EJ, Brewer HB. Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E. Science (New York, N.Y.). 211: 584-6. PMID 7455696  0.68
1981 Anderson DW, Schaefer EJ, Bronzert TJ, Lindgren FT, Forte T, Starzl TE, Niblack GD, Zech LA, Brewer HB. Transport of apolipoproteins A-I and A-II by human thoracic duct lymph. The Journal of Clinical Investigation. 67: 857-66. PMID 7204560  0.68
1981 Schaefer EJ, Anderson DW, Zech LA, Lindgren FT, Bronzert TB, Rubalcaba EA, Brewer HB. Metabolism of high density lipoprotein subfractions and constituents in Tangier disease following the infusion of high density lipoproteins. Journal of Lipid Research. 22: 217-28. PMID 6787156  0.68
1981 Zech LA, Gross EG, McClean SW. Lipoprotein metabolism in patients receiving synthetic retinoids isotretinoin and etretinate Arteriosclerosis. 1: 390a.  0.68
1980 Fisher WR, Zech LA, Bardalaye P, Warmke G, Berman M. The metabolism of apolipoprotein B in subjects with hypertriglyceridemia and polydisperse LDL. Journal of Lipid Research. 21: 760-74. PMID 7419987  0.68
1980 Schaefer EJ, Zech LA, Schwartz DE, Brewer HB. Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease). Annals of Internal Medicine. 93: 261-6. PMID 7406376  0.68
1979 Zech LA, Grundy SM, Steinberg D, Berman M. Kinetic model for production and metabolism of very low density lipoprotein triglycerides. Evidence for a slow production pathway and results for normolipidemic subjects. The Journal of Clinical Investigation. 63: 1262-73. PMID 221537 DOI: 10.1172/JCI109421  0.68
1978 Zech LA, Schaefer EJ, Brewer HB. Metabolism of plasma apolipoproteins A-I and A-II in man Circulation. 58: No. 146.  0.68
1978 Fisher WR, Zech LA, Warmke GL. Kinetics of apolipoprotein B (apo B) metabolism in polydisperse low density lipoprotein (LDL) of hyperpre-β-lipoproteinemic subjects Circulation. 58: No. 143.  0.68
1976 Zech LA, Grundy SM, Berman M. Triglyceride synthesis and metabolism in man: a model based on glycerol kinetics Circulation. 54: No.0010.  0.68
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