| Year |
Citation |
Score |
| 2023 |
Oleinik N, Albayram O, Kassir MF, Atilgan FC, Walton C, Karakaya E, Kurtz J, Alekseyenko A, Alsudani H, Sheridan M, Szulc ZM, Ogretmen B. Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects. Aging Cell. e13954. PMID 37614052 DOI: 10.1111/acel.13954 |
0.685 |
|
| 2022 |
Janneh AH, Kassir MF, Atilgan FC, Lee HG, Sheridan M, Oleinik N, Szulc Z, Voelkel-Johnson C, Nguyen H, Li H, Peterson YK, Marangoni E, Saatci O, Sahin O, Lilly M, ... ... Ogretmen B, et al. Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis. Cell Reports. 41: 111742. PMID 36476873 DOI: 10.1016/j.celrep.2022.111742 |
0.36 |
|
| 2022 |
White-Gilbertson S, Lu P, Esobi I, Echesabal-Chen J, Mulholland PJ, Gooz M, Ogretmen B, Stamatikos A, Voelkel-Johnson C. Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division. Scientific Reports. 12: 8971. PMID 35624221 DOI: 10.1038/s41598-022-12705-4 |
0.309 |
|
| 2022 |
Janneh AH, Ogretmen B. Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment. Cancers. 14. PMID 35565311 DOI: 10.3390/cancers14092183 |
0.342 |
|
| 2021 |
Lee WK, Maaß M, Quach A, Poscic N, Prangley H, Pallott EC, Kim JL, Pierce JS, Ogretmen B, Futerman AH, Thévenod F. Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. The Journal of Biological Chemistry. 101492. PMID 34915026 DOI: 10.1016/j.jbc.2021.101492 |
0.357 |
|
| 2021 |
Roth BM, DePalma RM, Cook ME, Varney KM, Weber DJ, Ogretmen B. H, C, and N backbone resonance assignments of the SET/TAF-1β/I2PP2A oncoprotein (residues 23-225). Biomolecular Nmr Assignments. PMID 34156643 DOI: 10.1007/s12104-021-10034-7 |
0.338 |
|
| 2021 |
Sheridan M, Ogretmen B. The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy. Cancers. 13. PMID 34069611 DOI: 10.3390/cancers13102475 |
0.301 |
|
| 2021 |
Lu P, White-Gilbertson S, Beeson G, Beeson C, Ogretmen B, Norris J, Voelkel-Johnson C. Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells. Cancers. 13. PMID 34062962 DOI: 10.3390/cancers13092212 |
0.353 |
|
| 2020 |
Yan F, Knochelmann HM, Morgan PF, Kaczmar JM, Neskey DM, Graboyes EM, Nguyen SA, Ogretmen B, Sharma AK, Day TA. The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020. Cancers. 12. PMID 32545409 DOI: 10.3390/Cancers12061543 |
0.329 |
|
| 2020 |
Pandruvada S, Still M, Goertzen J, Kelly A, Neville B, Huja S, Ogretmen B, Day T. Targeting tyrosine phosphatase SHP2 in oral cancers The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03346 |
0.31 |
|
| 2019 |
Oleinik N, Kim J, Roth BM, Selvam SP, Gooz M, Johnson RH, Lemasters JJ, Ogretmen B. Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress. Science Advances. 5: eaax1978. PMID 31535025 DOI: 10.1126/Sciadv.Aax1978 |
0.371 |
|
| 2019 |
Chakraborty P, Vaena SG, Thyagarajan K, Chatterjee S, Al-Khami A, Selvam SP, Nguyen H, Kang I, Wyatt MW, Baliga U, Hedley Z, Ngang RN, Guo B, Beeson GC, Husain S, ... ... Ogretmen B, et al. Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity. Cell Reports. 28: 1879-1893.e7. PMID 31412253 DOI: 10.1016/J.Celrep.2019.07.044 |
0.412 |
|
| 2019 |
Sofi MH, Wu Y, Schutt SD, Dai M, Daenthanasanmak A, Heinrichs Voss J, Nguyen H, Bastian D, Iamsawat S, Selvam SP, Liu C, Maulik N, Ogretmen B, Jin J, Mehrotra S, et al. Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease. The Journal of Clinical Investigation. 130. PMID 31045571 DOI: 10.1172/Jci122899 |
0.33 |
|
| 2019 |
Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen H, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball LE, Gangaraju V, Rubinstein MP, ... ... Ogretmen B, et al. Thioredoxin-1 improves the immuno-metabolic phenotype of anti-tumor T cells. The Journal of Biological Chemistry. PMID 30971427 DOI: 10.1074/Jbc.Ra118.006753 |
0.386 |
|
| 2019 |
De Palma RM, Parnham SR, Li Y, Oaks JJ, Peterson YK, Szulc ZM, Roth BM, Xing Y, Ogretmen B. The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201802264R. PMID 30917007 DOI: 10.1096/Fj.201802264R |
0.349 |
|
| 2019 |
Qie S, Yoshida A, Parnham S, Oleinik N, Beeson GC, Beeson CC, Ogretmen B, Bass AJ, Wong KK, Rustgi AK, Diehl JA. Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma. Nature Communications. 10: 1296. PMID 30899002 DOI: 10.1038/S41467-019-09179-W |
0.437 |
|
| 2018 |
Nguyen H, Kuril S, Bastian D, Kim J, Zhang M, Vaena SG, Dany M, Dai M, Heinrichs JL, Daenthanasanmak A, Iamsawat S, Schutt S, Fu J, Wu Y, Fairlie DP, ... ... Ogretmen B, et al. Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells. Jci Insight. 3. PMID 30568037 DOI: 10.1172/Jci.Insight.121697 |
0.328 |
|
| 2018 |
Nganga R, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Johnson KA, Parikh RY, Gangaraju V, Peterson Y, Dany M, Stahelin RV, Voelkel-Johnson C, Szulc ZM, Bieberich E, Ogretmen B. Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis. The Journal of Biological Chemistry. PMID 30420430 DOI: 10.1074/Jbc.Ra118.005865 |
0.346 |
|
| 2018 |
Nganga R, Oleinik N, Ogretmen B. Mechanisms of Ceramide-Dependent Cancer Cell Death. Advances in Cancer Research. 140: 1-25. PMID 30060806 DOI: 10.1016/Bs.Acr.2018.04.007 |
0.5 |
|
| 2018 |
Panneer Selvam S, Roth BM, Nganga R, Kim J, Cooley MA, Helke KL, Smith CD, Ogretmen B. Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. The Journal of Biological Chemistry. PMID 29748384 DOI: 10.1074/Jbc.Ra118.003506 |
0.81 |
|
| 2018 |
Helke K, Angel P, Lu P, Garrett-Mayer E, Ogretmen B, Drake R, Voelkel-Johnson C. Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis. Scientific Reports. 8: 1627. PMID 29374263 DOI: 10.1038/S41598-018-20102-Z |
0.345 |
|
| 2018 |
Das A, Zdzislaw S, Cachia D, Patel SJ, Ogretmen B. EXTH-51. C18-CERAMIDE ANALOGUE DRUG OVERCOMES RESISTANCE TO TEMOZOLOMIDE IN GLIOBLASTOMA Neuro-Oncology. 20: vi96-vi96. DOI: 10.1093/Neuonc/Noy148.399 |
0.311 |
|
| 2017 |
Ogretmen B. Sphingolipid metabolism in cancer signalling and therapy. Nature Reviews. Cancer. PMID 29147025 DOI: 10.1038/Nrc.2017.96 |
0.468 |
|
| 2017 |
Scheffel MJ, Helke K, Lu P, Bowers JS, Ogretmen B, Garrett-Mayer E, Paulos CM, Voelkel-Johnson C. Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis. Scientific Reports. 7: 15552. PMID 29138469 DOI: 10.1038/S41598-017-15791-X |
0.373 |
|
| 2017 |
Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, ... ... Ogretmen B, et al. CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metabolism. PMID 29129787 DOI: 10.1016/J.Cmet.2017.10.006 |
0.381 |
|
| 2017 |
Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH, Ogretmen B. TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis. Science Signaling. 10. PMID 29066540 DOI: 10.1126/Scisignal.Aam7464 |
0.79 |
|
| 2017 |
Thomas RJ, Oleinik N, Panneer Selvam S, Vaena SG, Dany M, Nganga RN, Depalma R, Baron KD, Kim J, Szulc ZM, Ogretmen B. HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy. Embo Molecular Medicine. PMID 28606997 DOI: 10.15252/Emmm.201607088 |
0.775 |
|
| 2017 |
Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, ... Ogretmen B, et al. Ceramide synthesis regulates T cell activity and GVHD development. Jci Insight. 2. PMID 28515365 DOI: 10.1172/Jci.Insight.91701 |
0.381 |
|
| 2017 |
Britten CD, Thomas MB, Garrett-Mayer E, Chin SH, Shirai K, Ogretmen B, Bentz TA, Brisendine A, Anderton K, Cusack SL, Maines LW, Zhuang Y, Smith CD. A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28420720 DOI: 10.1158/1078-0432.Ccr-16-2363 |
0.301 |
|
| 2017 |
Nguyen HD, Bastian D, Kuril S, Dany M, Fairlie D, Atkinson C, Ogretmen B, Tomlinson S, Yu X. Complement Promotes Gvhd through Suppressing Autophagy in Recipient Dendritic Cells after Allogeneic Hematopoietic Cell Transplantation in Mice Blood. 130: 1904-1904. DOI: 10.1182/Blood.V130.Suppl_1.1904.1904 |
0.326 |
|
| 2017 |
Selvam SP, Cooley M, Helke K, Garrett-Mayer E, Smith CD, Ogretmen B. Abstract 5474: Sphingosine kinase 2/sphingosine 1-phosphate signaling regulates p16 mediated accelerated aging in normal somatic tissues and tcf21 mediated tumor suppression in lung cancer Cancer Research. 77: 5474-5474. DOI: 10.1158/1538-7445.Am2017-5474 |
0.38 |
|
| 2016 |
Dany M, Gencer S, Nganga R, Thomas RJ, Oleinik N, Baron KD, Szulc ZM, Ruvolo P, Kornblau S, Andreeff M, Ogretmen B. Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML. Blood. PMID 27540013 DOI: 10.1182/Blood-2016-04-708750 |
0.512 |
|
| 2016 |
Fekry B, Jeffries KA, Esmaeilneakooshkghazi A, Ogretmen B, Krupenko SA, Krupenko NI. CerS6 is a Novel Transcriptional Target of p53 Activated by Non-Genotoxic Stress. The Journal of Biological Chemistry. PMID 27302066 DOI: 10.1074/Jbc.M116.716902 |
0.351 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Ogretmen B, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.334 |
|
| 2016 |
Gencer S, Oleinik N, Dany M, Ogretmen B. Abstract 4122: Ceramide is a key factor that regulates the crosstalk between TGF-ß and sonic hedgehog signaling at the basal cilia to control cell migration and tumor metastasis Cancer Research. 76: 4122-4122. DOI: 10.1158/1538-7445.Am2016-4122 |
0.454 |
|
| 2016 |
Dany M, Ogretmen B. ID: 92: CERAMIDE ACCUMULATION IN MITOCHONDRIA: A NOVEL THERAPEUTIC STRATEGY FOR ACUTE MYELOID LEUKEMIA VIA INDUCING LETHAL MITOPHAGY Journal of Investigative Medicine. 64: 947.1-947. DOI: 10.1136/jim-2016-000120.70 |
0.433 |
|
| 2015 |
Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Science Signaling. 8: ra58. PMID 26082434 DOI: 10.1126/Scisignal.Aaa4998 |
0.81 |
|
| 2015 |
Karlsson I, Zhou X, Thomas R, Smith AT, Bonner MY, Bakshi P, Banga AK, Bowen JP, Qabaja G, Ford SL, Ballard MD, Petersen KS, Li X, Chen G, Ogretmen B, et al. Solenopsin A and analogs exhibit ceramide-like biological activity. Vascular Cell. 7: 5. PMID 26015865 DOI: 10.1186/S13221-015-0030-2 |
0.472 |
|
| 2015 |
Tirodkar TS, Lu P, Bai A, Scheffel MJ, Gencer S, Garrett-Mayer E, Bielawska A, Ogretmen B, Voelkel-Johnson C. Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. The Journal of Biological Chemistry. 290: 13157-67. PMID 25839235 DOI: 10.1074/Jbc.M114.631325 |
0.433 |
|
| 2015 |
Dany M, Ogretmen B. Ceramide induced mitophagy and tumor suppression. Biochimica Et Biophysica Acta. 1853: 2834-45. PMID 25634657 DOI: 10.1016/J.Bbamcr.2014.12.039 |
0.452 |
|
| 2014 |
Oaks J, Ogretmen B. Regulation of PP2A by Sphingolipid Metabolism and Signaling. Frontiers in Oncology. 4: 388. PMID 25642418 DOI: 10.3389/Fonc.2014.00388 |
0.467 |
|
| 2014 |
Venkata JK, An N, Stuart R, Costa LJ, Cai H, Coker W, Song JH, Gibbs K, Matson T, Garrett-Mayer E, Wan Z, Ogretmen B, Smith C, Kang Y. Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma. Blood. 124: 1915-25. PMID 25122609 DOI: 10.1182/Blood-2014-03-559385 |
0.525 |
|
| 2014 |
Dai L, Plaisance-Bonstaff K, Voelkel-Johnson C, Smith CD, Ogretmen B, Qin Z, Parsons C. Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells. Plos One. 9: e102314. PMID 25010828 DOI: 10.1371/Journal.Pone.0102314 |
0.453 |
|
| 2014 |
Qin Z, Dai L, Trillo-Tinoco J, Senkal C, Wang W, Reske T, Bonstaff K, Del Valle L, Rodriguez P, Flemington E, Voelkel-Johnson C, Smith CD, Ogretmen B, Parsons C. Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Molecular Cancer Therapeutics. 13: 154-64. PMID 24140934 DOI: 10.1158/1535-7163.Mct-13-0466 |
0.782 |
|
| 2014 |
Jiang W, Ogretmen B. Autophagy paradox and ceramide. Biochimica Et Biophysica Acta. 1841: 783-92. PMID 24055889 DOI: 10.1016/J.Bbalip.2013.09.005 |
0.436 |
|
| 2013 |
Hamed HA, Das SK, Sokhi UK, Park MA, Cruickshanks N, Archer K, Ogretmen B, Grant S, Sarkar D, Fisher PB, Dent P. Combining histone deacetylase inhibitors with MDA-7/IL-24 enhances killing of renal carcinoma cells. Cancer Biology & Therapy. 14: 1039-49. PMID 24025359 DOI: 10.4161/Cbt.26110 |
0.327 |
|
| 2013 |
Neviani P, Harb JG, Oaks JJ, Santhanam R, Walker CJ, Ellis JJ, Ferenchak G, Dorrance AM, Paisie CA, Eiring AM, Ma Y, Mao HC, Zhang B, Wunderlich M, May PC, ... ... Ogretmen B, et al. PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells. The Journal of Clinical Investigation. 123: 4144-57. PMID 23999433 DOI: 10.1172/Jci68951 |
0.725 |
|
| 2013 |
Oaks JJ, Santhanam R, Walker CJ, Roof S, Harb JG, Ferenchak G, Eisfeld AK, Van Brocklyn JR, Briesewitz R, Saddoughi SA, Nagata K, Bittman R, Caligiuri MA, Abdel-Wahab O, Levine R, ... ... Ogretmen B, et al. Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies. Blood. 122: 1923-34. PMID 23926298 DOI: 10.1182/Blood-2013-03-492181 |
0.755 |
|
| 2013 |
Alberg AJ, Armeson K, Pierce JS, Bielawski J, Bielawska A, Visvanathan K, Hill EG, Ogretmen B. Plasma sphingolipids and lung cancer: a population-based, nested case-control study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 22: 1374-82. PMID 23749868 DOI: 10.1158/1055-9965.Epi-12-1424 |
0.333 |
|
| 2013 |
Selvam SP, Ogretmen B. Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance. Handbook of Experimental Pharmacology. 3-27. PMID 23563649 DOI: 10.1007/978-3-7091-1511-4_1 |
0.438 |
|
| 2013 |
Hoeferlin LA, Fekry B, Ogretmen B, Krupenko SA, Krupenko NI. Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6. The Journal of Biological Chemistry. 288: 12880-90. PMID 23519469 DOI: 10.1074/Jbc.M113.461798 |
0.464 |
|
| 2013 |
Saddoughi SA, Ogretmen B. Diverse functions of ceramide in cancer cell death and proliferation. Advances in Cancer Research. 117: 37-58. PMID 23290776 DOI: 10.1016/B978-0-12-394274-6.00002-9 |
0.742 |
|
| 2013 |
Jiang W, Ogretmen B. Ceramide stress in survival versus lethal autophagy paradox: ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Autophagy. 9: 258-9. PMID 23182807 DOI: 10.4161/Auto.22739 |
0.404 |
|
| 2013 |
Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, ... ... Ogretmen B, et al. Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. Embo Molecular Medicine. 5: 105-21. PMID 23180565 DOI: 10.1002/Emmm.201201283 |
0.803 |
|
| 2013 |
Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, et al. LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria. The Journal of Pharmacology and Experimental Therapeutics. 344: 167-78. PMID 23086228 DOI: 10.1124/Jpet.112.199216 |
0.426 |
|
| 2013 |
Qin Z, Dai L, Plaisance-Bonstaff K, Senkal C, Wang W, Reske TM, Del Valle L, Voelkel-Johnson C, Flemington E, Ogretmen B, Smith CD, Parsons C. Targeting Sphingosine Kinase Induces Apoptosis and Regression Of Virus-Associated Lymphoma In Vivo Blood. 122: 4414-4414. DOI: 10.1182/Blood.V122.21.4414.4414 |
0.768 |
|
| 2012 |
Syed I, Szulc ZM, Ogretmen B, Kowluru A. L- threo -C6-pyridinium-ceramide bromide, a novel cationic ceramide, induces NADPH oxidase activation, mitochondrial dysfunction and loss in cell viability in INS 832/13 β-cells. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 1051-8. PMID 23052231 DOI: 10.1159/000341481 |
0.394 |
|
| 2012 |
Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nature Chemical Biology. 8: 831-8. PMID 22922758 DOI: 10.1038/Nchembio.1059 |
0.787 |
|
| 2012 |
Ponnusamy S, Selvam SP, Mehrotra S, Kawamori T, Snider AJ, Obeid LM, Shao Y, Sabbadini R, Ogretmen B. Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. Embo Molecular Medicine. 4: 761-75. PMID 22707406 DOI: 10.1002/Emmm.201200244 |
0.425 |
|
| 2012 |
Bareford MD, Hamed HA, Allegood J, Cruickshanks N, Poklepovic A, Park MA, Ogretmen B, Spiegel S, Grant S, Dent P. Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling. Cancer Biology & Therapy. 13: 793-803. PMID 22673740 DOI: 10.4161/Cbt.20562 |
0.503 |
|
| 2012 |
Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Molecular Cancer Therapeutics. 11: 1092-102. PMID 22452947 DOI: 10.1158/1535-7163.Mct-11-0705 |
0.794 |
|
| 2012 |
Booth L, Cazanave SC, Hamed HA, Yacoub A, Ogretmen B, Chen CS, Grant S, Dent P. OSU-03012 suppresses GRP78/BiP expression that causes PERK-dependent increases in tumor cell killing. Cancer Biology & Therapy. 13: 224-36. PMID 22354011 DOI: 10.4161/Cbt.13.4.18877 |
0.456 |
|
| 2012 |
Meyers-Needham M, Ponnusamy S, Gencer S, Jiang W, Thomas RJ, Senkal CE, Ogretmen B. Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells. Embo Molecular Medicine. 4: 78-92. PMID 22180294 DOI: 10.1002/Emmm.201100189 |
0.723 |
|
| 2012 |
Mohan N, Ogretmen B, Banik NL, Ray SK. Abstract 4113: Combination of LC3 II shRNA and genistein completely inhibited rapamycin-induced autophagy and promoted apoptosis in human malignant neuroblastoma cell lines Cancer Research. 72: 4113-4113. DOI: 10.1158/1538-7445.Am2012-4113 |
0.481 |
|
| 2011 |
Simon GR, Saddoughi S, Mukhopadhyay A, Peterson Y, Senkal CE, Oaks J, Perrotti D, Hannun Y, Ogretmen B. Targeting I2PP2A by FTY720: A novel, mechanism-based treatment strategy for patients with advanced and previously treated non-small cell lung cancer (NSCLC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 7574. PMID 28023125 DOI: 10.1200/Jco.2011.29.15_Suppl.7574 |
0.814 |
|
| 2011 |
Shirai K, Saddoughi S, O'Brien PE, Afrin L, Garrett-Mayer E, Simon GR, Chaudhary UB, Ogretmen B. Serum C18-ceramide as a biomarker for response: Phase II trial of gemcitabine plus doxorubicin in patients with HNSCC. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 5590. PMID 28022062 DOI: 10.1200/Jco.2011.29.15_Suppl.5590 |
0.71 |
|
| 2011 |
Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. The Journal of Biological Chemistry. 286: 42446-58. PMID 22013072 DOI: 10.1074/Jbc.M111.287383 |
0.819 |
|
| 2011 |
Baran Y, Bielawski J, Gunduz U, Ogretmen B. Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation. Journal of Cancer Research and Clinical Oncology. 137: 1535-44. PMID 21833718 DOI: 10.1007/S00432-011-1016-Y |
0.4 |
|
| 2011 |
Saddoughi SA, Garrett-Mayer E, Chaudhary U, O'Brien PE, Afrin LB, Day TA, Gillespie MB, Sharma AK, Wilhoit CS, Bostick R, Senkal CE, Hannun YA, Bielawski J, Simon GR, Shirai K, ... Ogretmen B, et al. Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum Câ‚₈-ceramide as a novel biomarker for monitoring response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6097-105. PMID 21791630 DOI: 10.1158/1078-0432.Ccr-11-0930 |
0.776 |
|
| 2011 |
Salas A, Ponnusamy S, Senkal CE, Meyers-Needham M, Selvam SP, Saddoughi SA, Apohan E, Sentelle RD, Smith C, Gault CR, Obeid LM, El-Shewy HM, Oaks J, Santhanam R, Marcucci G, ... ... Ogretmen B, et al. Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. Blood. 117: 5941-52. PMID 21527515 DOI: 10.1182/Blood-2010-08-300772 |
0.764 |
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| 2011 |
Shirai K, Kaneshiro T, Wada M, Furuya H, Bielawski J, Hannun YA, Obeid LM, Ogretmen B, Kawamori T. A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prevention Research (Philadelphia, Pa.). 4: 454-62. PMID 21209394 DOI: 10.1158/1940-6207.Capr-10-0299 |
0.482 |
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| 2011 |
Separovic D, Bielawski J, Pierce JS, Merchant S, Tarca AL, Bhatti G, Ogretmen B, Korbelik M. Enhanced tumor cures after Foscan photodynamic therapy combined with the ceramide analog LCL29. Evidence from mouse squamous cell carcinomas for sphingolipids as biomarkers of treatment response International Journal of Oncology. 38: 521-527. PMID 21152858 DOI: 10.3892/Ijo.2010.863 |
0.364 |
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| 2011 |
Park MA, Hamed HA, Mitchell C, Cruickshanks N, Dash R, Allegood J, Dmitriev IP, Tye G, Ogretmen B, Spiegel S, Yacoub A, Grant S, Curiel DT, Fisher PB, Dent P. A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels. Molecular Pharmacology. 79: 368-80. PMID 21119025 DOI: 10.1124/Mol.110.069484 |
0.394 |
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| 2011 |
Oaks JJ, Mukhopadhyay A, Santhanam R, Saddoughi SA, Neviani P, Harb JG, Ogretmen B, Bittman R, Levine RL, Quintás-Cardama A, Marcucci G, Perrotti D. FTY720 Restores PP2A Tumor Suppressor Activity in Polycythemia Vera CD34+ Progenitors Through Inhibition of Jak2 V617F- and PI-3Kγ-Dependent SET Serine Phosphorylation and Enhancement of NOS-Dependent PP2A Tyrosine Nitration Blood. 118: 2494-2494. DOI: 10.1182/Blood.V118.21.2494.2494 |
0.749 |
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| 2011 |
Ogretmen B, Sentelle D, Senkal CE. Abstract 2875: Ceramide suffocates cancer cells to death: Regulation of mitophagy by ceramide signaling Cancer Research. 71: 2875-2875. DOI: 10.1158/1538-7445.Am2011-2875 |
0.785 |
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| 2010 |
Ponnusamy S, Meyers-Needham M, Senkal CE, Saddoughi SA, Sentelle D, Selvam SP, Salas A, Ogretmen B. Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. Future Oncology (London, England). 6: 1603-24. PMID 21062159 DOI: 10.2217/Fon.10.116 |
0.826 |
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| 2010 |
Park MA, Reinehr R, Häussinger D, Voelkel-Johnson C, Ogretmen B, Yacoub A, Grant S, Dent P. Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells. Molecular Cancer Therapeutics. 9: 2220-31. PMID 20682655 DOI: 10.1158/1535-7163.Mct-10-0274 |
0.319 |
|
| 2010 |
Park MA, Mitchell C, Zhang G, Yacoub A, Allegood J, Häussinger D, Reinehr R, Larner A, Spiegel S, Fisher PB, Voelkel-Johnson C, Ogretmen B, Grant S, Dent P. Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Cancer Research. 70: 6313-24. PMID 20631069 DOI: 10.1158/0008-5472.Can-10-0999 |
0.4 |
|
| 2010 |
Yacoub A, Hamed HA, Allegood J, Mitchell C, Spiegel S, Lesniak MS, Ogretmen B, Dash R, Sarkar D, Broaddus WC, Grant S, Curiel DT, Fisher PB, Dent P. PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells. Cancer Research. 70: 1120-9. PMID 20103619 DOI: 10.1158/0008-5472.Can-09-4043 |
0.449 |
|
| 2010 |
Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B. Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 296-308. PMID 19723703 DOI: 10.1096/Fj.09-135087 |
0.767 |
|
| 2010 |
Oaks JJ, Mukhopadhyay A, Santhanam R, Saddoughi SA, Walker C, Neviani P, Harb JG, Ma Y, Verstovsek S, Marcucci G, Briesewitz R, Bittman R, Chen C, Quintas-Cardama A, Ogretmen B, et al. Pharmacologic Restoration of PP2A Activity and Interference with the SET-PP2A Interplay by FTY720 and Its Non-Immunosuppressive Derivative as a Novel and Efficient Therapy for Ph-Negative Myeloproliferative Disorders Blood. 116: 775-775. DOI: 10.1182/Blood.V116.21.775.775 |
0.754 |
|
| 2010 |
Shirai K, Furuya H, Wada M, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Kawamori T. Abstract 5656: Role for Sphingosine kinase 1 in head & neck cancer Cancer Research. 70: 5656-5656. DOI: 10.1158/1538-7445.Am10-5656 |
0.414 |
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| 2010 |
Saddoughi S, Mukhopadhyay A, Ogretmen B. Abstract A26: Direct interaction between ceramide and SET/I2PP2A restores nuclear PP2A activity leading to the degradation of cMyc and suppression of lung tumor growth Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcme10-A26 |
0.751 |
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| 2009 |
Demarse NA, Ponnusamy S, Spicer EK, Apohan E, Baatz JE, Ogretmen B, Davies C. Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation. Journal of Molecular Biology. 394: 789-803. PMID 19800890 DOI: 10.1016/J.Jmb.2009.09.062 |
0.41 |
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| 2009 |
Patwardhan GA, Zhang QJ, Yin D, Gupta V, Bao J, Senkal CE, Ogretmen B, Cabot MC, Shah GV, Sylvester PW, Jazwinski SM, Liu YY. A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. Plos One. 4: e6938. PMID 19742320 DOI: 10.1371/Journal.Pone.0006938 |
0.745 |
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| 2009 |
Separovic D, Bielawski J, Pierce JS, Merchant S, Tarca AL, Ogretmen B, Korbelik M. Increased tumour dihydroceramide production after Photofrin-PDT alone and improved tumour response after the combination with the ceramide analogue LCL29. Evidence from mouse squamous cell carcinomas British Journal of Cancer. 100: 626-632. PMID 19223911 DOI: 10.1038/Sj.Bjc.6604896 |
0.382 |
|
| 2009 |
White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L, Voelkel-Johnson C. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells Oncogene. 28: 1132-1141. PMID 19137010 DOI: 10.1038/Onc.2008.468 |
0.779 |
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| 2009 |
Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 751-63. PMID 19028839 DOI: 10.1096/Fj.08-120550 |
0.821 |
|
| 2009 |
Oaks J, Neviani P, Mukhopadhyay A, Santhanam R, Ma Y, Mao C, Marcucci G, Chen C, Cortes J, Caligiuri MA, Hokland P, Huettner C, Koschmieder S, Cancelas J, Briesewitz R, ... ... Ogretmen B, et al. FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor. Blood. 114: 3259-3259. DOI: 10.1182/Blood.V114.22.3259.3259 |
0.454 |
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| 2008 |
Saddoughi SA, Song P, Ogretmen B. Roles of bioactive sphingolipids in cancer biology and therapeutics. Sub-Cellular Biochemistry. 49: 413-40. PMID 18751921 DOI: 10.1007/978-1-4020-8831-5_16 |
0.756 |
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| 2008 |
Ponnusamy S, Alderson NL, Hama H, Bielawski J, Jiang JC, Bhandari R, Snyder SH, Jazwinski SM, Ogretmen B. Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function. The Journal of Biological Chemistry. 283: 27514-24. PMID 18694931 DOI: 10.1074/Jbc.M802980200 |
0.392 |
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| 2007 |
Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, Norris JS, Hannun YA, Ogretmen B. Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Letters. 256: 101-11. PMID 17619081 DOI: 10.1016/J.Canlet.2007.06.003 |
0.72 |
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| 2007 |
Wooten-Blanks LG, Song P, Senkal CE, Ogretmen B. Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3386-97. PMID 17548428 DOI: 10.1096/Fj.07-8621Com |
0.736 |
|
| 2007 |
Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B. Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Molecular Cancer Therapeutics. 6: 712-22. PMID 17308067 DOI: 10.1158/1535-7163.Mct-06-0558 |
0.784 |
|
| 2007 |
Baran Y, Salas A, Senkal CE, Gunduz U, Bielawski J, Obeid LM, Ogretmen B. Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. The Journal of Biological Chemistry. 282: 10922-34. PMID 17303574 DOI: 10.1074/Jbc.M610157200 |
0.829 |
|
| 2007 |
Kraveka JM, Li L, Szulc ZM, Bielawski J, Ogretmen B, Hannun YA, Obeid LM, Bielawska A. Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. The Journal of Biological Chemistry. 282: 16718-28. PMID 17283068 DOI: 10.1074/Jbc.M700647200 |
0.464 |
|
| 2006 |
Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. The Journal of Biological Chemistry. 281: 36793-802. PMID 17030510 DOI: 10.1074/Jbc.M608137200 |
0.739 |
|
| 2006 |
Ogretmen B. Sphingolipids in cancer: regulation of pathogenesis and therapy. Febs Letters. 580: 5467-76. PMID 16970943 DOI: 10.1016/J.Febslet.2006.08.052 |
0.383 |
|
| 2006 |
Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 317: 1188-99. PMID 16510697 DOI: 10.1124/Jpet.106.101949 |
0.733 |
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| 2006 |
Sultan I, Senkal CE, Ponnusamy S, Bielawski J, Szulc Z, Bielawska A, Hannun YA, Ogretmen B. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. The Biochemical Journal. 393: 513-21. PMID 16201965 DOI: 10.1042/Bj20051083 |
0.739 |
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| 2005 |
Wooten LG, Ogretmen B. Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide. The Journal of Biological Chemistry. 280: 28867-76. PMID 15951564 DOI: 10.1074/Jbc.M413444200 |
0.406 |
|
| 2005 |
Johnson KR, Johnson KY, Crellin HG, Ogretmen B, Boylan AM, Harley RA, Obeid LM. Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1159-66. PMID 15923363 DOI: 10.1369/Jhc.4A6606.2005 |
0.395 |
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| 2005 |
Rossi MJ, Sundararaj K, Koybasi S, Phillips MS, Szulc ZM, Bielawska A, Day TA, Obeid LM, Hannun YA, Ogretmen B. Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 132: 55-62. PMID 15632910 DOI: 10.1016/J.Otohns.2004.08.015 |
0.428 |
|
| 2004 |
Koybasi S, Senkal CE, Sundararaj K, Spassieva S, Bielawski J, Osta W, Day TA, Jiang JC, Jazwinski SM, Hannun YA, Obeid LM, Ogretmen B. Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas Journal of Biological Chemistry. 279: 44311-44319. PMID 15317812 DOI: 10.1074/Jbc.M406920200 |
0.756 |
|
| 2004 |
Ogretmen B, Hannun YA. Biologically active sphingolipids in cancer pathogenesis and treatment. Nature Reviews. Cancer. 4: 604-16. PMID 15286740 DOI: 10.1038/Nrc1411 |
0.417 |
|
| 2004 |
Sundararaj KP, Wood RE, Ponnusamy S, Salas AM, Szulc Z, Bielawska A, Obeid LM, Hannun YA, Ogretmen B. Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. The Journal of Biological Chemistry. 279: 6152-62. PMID 14630908 DOI: 10.1074/Jbc.M310549200 |
0.696 |
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| 2003 |
Kraveka JM, Li L, Bielawski J, Obeid LM, Ogretmen B. Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. Archives of Biochemistry and Biophysics. 419: 110-9. PMID 14592454 DOI: 10.1016/J.Abb.2003.08.034 |
0.456 |
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| 2002 |
Wu CH, Gordon J, Rastegar M, Ogretmen B, Safa AR. Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant. Oncogene. 21: 5160-74. PMID 12140766 DOI: 10.1038/Sj.Onc.1205639 |
0.474 |
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| 2002 |
Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. The Journal of Biological Chemistry. 277: 12960-9. PMID 11815611 DOI: 10.1074/Jbc.M110699200 |
0.421 |
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| 2002 |
Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, Hannun YA. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. The Journal of Biological Chemistry. 277: 12587-95. PMID 11801602 DOI: 10.1074/Jbc.M112010200 |
0.425 |
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| 2001 |
Ogretmen B, Hannun YA. Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance Drug Resistance Updates. 4: 368-377. PMID 12030784 DOI: 10.1054/Drup.2001.0225 |
0.475 |
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| 2001 |
Chalfant CE, Ogretmen B, Galadari S, Kroesen BJ, Pettus BJ, Hannun YA. FAS Activation Induces Dephosphorylation of SR Proteins: Dependence on the de novo generation of ceramide and activation of protein phosphatase 1 Journal of Biological Chemistry. 276: 44848-44855. PMID 11502750 DOI: 10.1074/Jbc.M106291200 |
0.427 |
|
| 2001 |
Boujaoude LC, Bradshaw-Wilder C, Mao C, Cohn J, Ogretmen B, Hannun YA, Obeid LM. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: Modulation of cellular activity of sphingosine 1-phosphate Journal of Biological Chemistry. 276: 35258-35264. PMID 11443135 DOI: 10.1074/Jbc.M105442200 |
0.428 |
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| 2001 |
Ogretmen B, Kraveka JM, Schady D, Usta J, Hannun YA, Obeid LM. Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line Journal of Biological Chemistry. 276: 32506-32514. PMID 11441001 DOI: 10.1074/Jbc.M101350200 |
0.452 |
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| 2001 |
Ogretmen B, Schady D, Usta J, Wood R, Kraveka JM, Luberto C, Birbes H, Hannun YA, Obeid LM. Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells Journal of Biological Chemistry. 276: 24901-24910. PMID 11335714 DOI: 10.1074/Jbc.M100314200 |
0.475 |
|
| 2000 |
Ogretmen B, Barredo JC, Safa AR. Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia Journal of Pediatric Hematology/Oncology. 22: 45-49. PMID 10695821 DOI: 10.1097/00043426-200001000-00009 |
0.317 |
|
| 2000 |
Ogretmen B, Safa AR. Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line Biochemistry. 39: 194-204. PMID 10625494 DOI: 10.1021/Bi991943F |
0.394 |
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| 1999 |
Ogretmen B, Safa AR. Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-κb/p65 and c-Fos transcription factors and their interaction with the CAAT region Biochemistry. 38: 2189-2199. PMID 10026303 DOI: 10.1021/Bi982236+ |
0.423 |
|
| 1998 |
Ogretmen B, Bahadori H, McCauley M, Boylan A, Green M, Safa AR. Lack of correlation of MRP and γ-glutamylcysteine synthetase overexpression with doxorubicin resistance due to increased apoptosis in SV40 large T-antigen-transformed human mesothelial cells Cancer Chemotherapy and Pharmacology. 42: 441-446. PMID 9788569 DOI: 10.1007/S002800050843 |
0.465 |
|
| 1998 |
Ogretmen B, McCauley MD, Safa AR. Molecular mechanisms of loss of β2-microglobulin expression in drug- resistant breast cancer sublines and its involvement in drug resistance Biochemistry. 37: 11679-11691. PMID 9709006 DOI: 10.1021/Bi980573C |
0.404 |
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| 1998 |
Ogretmen B, Bahadori HR, Mccauley MD, Boylan A, Green MR, Safa AR. Co-ordinated over-expression of the MRP and γ-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines International Journal of Cancer. 75: 757-761. PMID 9495245 DOI: 10.1002/(Sici)1097-0215(19980302)75:5<757::Aid-Ijc15>3.0.Co;2-3 |
0.37 |
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| 1997 |
Ogretmen B, Safa AR. Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells Oncogene. 14: 499-506. PMID 9053847 DOI: 10.1038/Sj.Onc.1200855 |
0.401 |
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| 1996 |
Ogretmen B, Safa AR. Down-regulation of apoptosis-related bcl-2 but not bcl-x(L) or bax proteins in multidrug-resistant MCF-7/Adr human breast cancer cells International Journal of Cancer. 67: 608-614. PMID 8782646 DOI: 10.1002/(Sici)1097-0215(19960904)67:5<608::Aid-Ijc3>3.0.Co;2-Y |
0.46 |
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