Jeff Saucerman - Publications

Biomedical Engineering University of Virginia, Charlottesville, VA 
Cardiac signaing, Computational biology

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Estrada AC, Yoshida K, Saucerman JJ, Holmes JW. A multiscale model of cardiac concentric hypertrophy incorporating both mechanical and hormonal drivers of growth. Biomechanics and Modeling in Mechanobiology. PMID 32970240 DOI: 10.1007/s10237-020-01385-6  0.68
2020 Cao S, Aboelkassem Y, Wang A, Valdez-Jasso D, Saucerman JJ, Omens JH, McCulloch AD. Quantification of model and data uncertainty in a network analysis of cardiac myocyte mechanosignalling. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 378: 20190336. PMID 32448062 DOI: 10.1098/Rsta.2019.0336  1
2020 Zeigler AC, Nelson AR, Chandrabhatla AS, Brazhkina O, Holmes JW, Saucerman JJ. Computational Model Predicts Paracrine and Intracellular Drivers of Fibroblast Phenotype After Myocardial Infarction. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 32209358 DOI: 10.1016/J.Matbio.2020.03.007  0.68
2019 Rikard SM, Athey TL, Nelson AR, Christiansen SLM, Lee JJ, Holmes JW, Peirce SM, Saucerman JJ. Multiscale Coupling of an Agent-Based Model of Tissue Fibrosis and a Logic-Based Model of Intracellular Signaling. Frontiers in Physiology. 10: 1481. PMID 31920691 DOI: 10.3389/Fphys.2019.01481  0.68
2019 Saucerman JJ, Tan PM, Buchholz KS, McCulloch AD, Omens JH. Mechanical regulation of gene expression in cardiac myocytes and fibroblasts. Nature Reviews. Cardiology. PMID 30683889 DOI: 10.1038/S41569-019-0155-8  1
2018 Sutcliffe MD, Tan PM, Fernandez-Perez A, Nam YJ, Munshi NV, Saucerman JJ. High content analysis identifies unique morphological features of reprogrammed cardiomyocytes. Scientific Reports. 8: 1258. PMID 29352247 DOI: 10.1038/S41598-018-19539-Z  0.52
2017 Tan PM, Buchholz KS, Omens JH, McCulloch AD, Saucerman JJ. Predictive model identifies key network regulators of cardiomyocyte mechano-signaling. Plos Computational Biology. 13: e1005854. PMID 29131824 DOI: 10.1371/Journal.Pcbi.1005854  1
2016 Lindsey ML, Saucerman JJ, DeLeon-Pennell K. Knowledge gaps to understanding cardiac macrophage polarization following myocardial infarction. Biochimica Et Biophysica Acta. PMID 27240543 DOI: 10.1016/J.Bbadis.2016.05.013  1
2016 Zeigler AC, Richardson WJ, Holmes JW, Saucerman JJ. A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation. Journal of Molecular and Cellular Cardiology. PMID 27017945 DOI: 10.1016/J.Yjmcc.2016.03.008  1
2015 Zeigler AC, Richardson WJ, Holmes JW, Saucerman JJ. Computational modeling of cardiac fibroblasts and fibrosis. Journal of Molecular and Cellular Cardiology. PMID 26608708 DOI: 10.1016/J.Yjmcc.2015.11.020  1
2015 Ryall KA, Saucerman JJ. Automated microscopy of cardiac myocyte hypertrophy: a case study on the role of intracellular α-adrenergic receptors. Methods in Molecular Biology (Clifton, N.J.). 1234: 123-34. PMID 25304353 DOI: 10.1007/978-1-4939-1755-6_11  1
2014 Amanfu RK, Saucerman JJ. Modeling the effects of β1-adrenergic receptor blockers and polymorphisms on cardiac myocyte Ca2+ handling. Molecular Pharmacology. 86: 222-30. PMID 24867460 DOI: 10.1124/Mol.113.090951  1
2014 Laker RC, Xu P, Ryall KA, Sujkowski A, Kenwood BM, Chain KH, Zhang M, Royal MA, Hoehn KL, Driscoll M, Adler PN, Wessells RJ, Saucerman JJ, Yan Z. A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo. The Journal of Biological Chemistry. 289: 12005-15. PMID 24644293 DOI: 10.1074/Jbc.M113.530527  1
2014 Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, ... Saucerman JJ, et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Molecular Metabolism. 3: 114-23. PMID 24634817 DOI: 10.1016/J.Molmet.2013.11.005  1
2014 Ryall KA, Bezzerides VJ, Rosenzweig A, Saucerman JJ. Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation. Journal of Molecular and Cellular Cardiology. 72: 74-84. PMID 24613264 DOI: 10.1016/J.Yjmcc.2014.02.013  1
2014 Saucerman JJ, Greenwald EC, Polanowska-Grabowska R. Mechanisms of cyclic AMP compartmentation revealed by computational models. The Journal of General Physiology. 143: 39-48. PMID 24378906 DOI: 10.1085/Jgp.201311044  1
2014 Greenwald EC, Redden JM, Dodge-Kafka KL, Saucerman JJ. Scaffold state switching amplifies, accelerates, and insulates protein kinase C signaling. The Journal of Biological Chemistry. 289: 2353-60. PMID 24302730 DOI: 10.1074/Jbc.M113.497941  1
2014 Yang JH, Polanowska-Grabowska RK, Smith JS, Shields CW, Saucerman JJ. PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling. Journal of Molecular and Cellular Cardiology. 66: 83-93. PMID 24225179 DOI: 10.1016/J.Yjmcc.2013.11.001  1
2014 Greenwald EC, Polanowska-Grabowska RK, Saucerman JJ. Integrating fluorescent biosensor data using computational models. Methods in Molecular Biology (Clifton, N.J.). 1071: 227-48. PMID 24052393 DOI: 10.1007/978-1-62703-622-1_18  1
2013 Saucerman JJ. Modeling mitochondrial ROS: a great balancing act. Biophysical Journal. 105: 1287-8. PMID 24047977 DOI: 10.1016/J.Bpj.2013.08.013  1
2013 Cui WY, Zhao S, Polanowska-Grabowska R, Wang J, Wei J, Dash B, Chang SL, Saucerman JJ, Gu J, Li MD. Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages. Molecular Pharmacology. 83: 61-72. PMID 23028093 DOI: 10.1124/Mol.112.081497  1
2012 Ryall KA, Holland DO, Delaney KA, Kraeutler MJ, Parker AJ, Saucerman JJ. Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling. The Journal of Biological Chemistry. 287: 42259-68. PMID 23091058 DOI: 10.1074/Jbc.M112.382937  1
2012 Ryall KA, Saucerman JJ. Automated imaging reveals a concentration dependent delay in reversibility of cardiac myocyte hypertrophy. Journal of Molecular and Cellular Cardiology. 53: 282-90. PMID 22575844 DOI: 10.1016/J.Yjmcc.2012.04.016  1
2012 Sample V, DiPilato LM, Yang JH, Ni Q, Saucerman JJ, Zhang J. Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nature Chemical Biology. 8: 375-82. PMID 22366721 DOI: 10.1038/Nchembio.799  1
2012 Yang JH, Saucerman JJ. Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy. Journal of Molecular and Cellular Cardiology. 52: 1048-55. PMID 22289214 DOI: 10.1016/J.Yjmcc.2011.12.015  1
2012 Raynor LL, Saucerman JJ, Akinola MO, Lake DE, Moorman JR, Fairchild KD. Cytokine screening identifies NICU patients with Gram-negative bacteremia. Pediatric Research. 71: 261-6. PMID 22278182 DOI: 10.1038/Pr.2011.45  1
2012 Bass GT, Ryall KA, Katikapalli A, Taylor BE, Dang ST, Acton ST, Saucerman JJ. Automated image analysis identifies signaling pathways regulating distinct signatures of cardiac myocyte hypertrophy. Journal of Molecular and Cellular Cardiology. 52: 923-30. PMID 22142594 DOI: 10.1016/J.Yjmcc.2011.11.009  1
2012 Saucerman JJ. Cardiac biexcitability: two ways to catch a wave. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 123-4. PMID 21893138 DOI: 10.1016/J.Hrthm.2011.09.001  1
2012 Saucerman JJ, Bers DM. Calmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytes. Journal of Molecular and Cellular Cardiology. 52: 312-6. PMID 21708171 DOI: 10.1016/J.Yjmcc.2011.06.005  1
2011 Amanfu RK, Muller JB, Saucerman JJ. Automated image analysis of cardiac myocyte Ca2+ dynamics. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 4661-4. PMID 22255377 DOI: 10.1109/IEMBS.2011.6091154  1
2011 Amanfu RK, Saucerman JJ. Cardiac models in drug discovery and development: a review. Critical Reviews in Biomedical Engineering. 39: 379-95. PMID 22196160 DOI: 10.1615/Critrevbiomedeng.V39.I5.30  1
2011 Haggart CR, Bartell JA, Saucerman JJ, Papin JA. Whole-genome metabolic network reconstruction and constraint-based modeling. Methods in Enzymology. 500: 411-33. PMID 21943909 DOI: 10.1016/B978-0-12-385118-5.00021-9  1
2011 Holland DO, Krainak NC, Saucerman JJ. Graphical approach to model reduction for nonlinear biochemical networks. Plos One. 6: e23795. PMID 21901136 DOI: 10.1371/Journal.Pone.0023795  1
2011 Soltis AR, Saucerman JJ. Robustness portraits of diverse biological networks conserved despite order-of-magnitude parameter uncertainty. Bioinformatics (Oxford, England). 27: 2888-94. PMID 21880701 DOI: 10.1093/Bioinformatics/Btr496  1
2011 Greenwald EC, Saucerman JJ. Bigger, better, faster: principles and models of AKAP anchoring protein signaling. Journal of Cardiovascular Pharmacology. 58: 462-9. PMID 21562426 DOI: 10.1097/Fjc.0B013E31822001E3  1
2011 Yang JH, Saucerman JJ. Computational models reduce complexity and accelerate insight into cardiac signaling networks. Circulation Research. 108: 85-97. PMID 21212391 DOI: 10.1161/Circresaha.110.223602  1
2011 Benedict KF, Mac Gabhann F, Amanfu RK, Chavali AK, Gianchandani EP, Glaw LS, Oberhardt MA, Thorne BC, Yang JH, Papin JA, Peirce SM, Saucerman JJ, Skalak TC. Systems analysis of small signaling modules relevant to eight human diseases. Annals of Biomedical Engineering. 39: 621-35. PMID 21132372 DOI: 10.1007/S10439-010-0208-Y  1
2010 Kraeutler MJ, Soltis AR, Saucerman JJ. Modeling cardiac β-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model. Bmc Systems Biology. 4: 157. PMID 21087478 DOI: 10.1186/1752-0509-4-157  1
2010 Soltis AR, Saucerman JJ. Synergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling. Biophysical Journal. 99: 2038-47. PMID 20923637 DOI: 10.1016/J.Bpj.2010.08.016  1
2009 Fairchild KD, Saucerman JJ, Raynor LL, Sivak JA, Xiao Y, Lake DE, Moorman JR. Endotoxin depresses heart rate variability in mice: cytokine and steroid effects. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 297: R1019-27. PMID 19657103 DOI: 10.1152/Ajpregu.00132.2009  1
2009 Lu S, Michailova A, Saucerman J, Cheng Y, Yu Z, Kaiser T, Li W, Bank R, Holst M, McCammon J, Hayashi T, Hoshijima M, Arzberger P, McCulloch A. Multiscale modeling in rodent ventricular myocytes. Ieee Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society. 28: 46-57. PMID 19349251 DOI: 10.1109/Memb.2009.931787  1
2009 Allen T, Saucerman J, Papin J, Peirce-Cottler S. Development and assessment of a novel systems bioengineering course integrating modeling and experimentation Asee Annual Conference and Exposition, Conference Proceedings 1
2008 Song Q, Saucerman JJ, Bossuyt J, Bers DM. Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. The Journal of Biological Chemistry. 283: 31531-40. PMID 18790737 DOI: 10.1074/Jbc.M804902200  1
2008 Saucerman JJ, Bers DM. Calmodulin mediates differential sensitivity of CaMKII and calcineurin to local Ca2+ in cardiac myocytes. Biophysical Journal. 95: 4597-612. PMID 18689454 DOI: 10.1529/Biophysj.108.128728  1
2008 Yang JH, Saucerman JJ. Multi-scale model of phospholamban mutations in the mouse heart Wmsci 2008 - the 12th World Multi-Conference On Systemics, Cybernetics and Informatics, Jointly With the 14th International Conference On Information Systems Analysis and Synthesis, Isas 2008 - Proc.. 2: 147-148.  1
2006 Saucerman JJ, McCulloch AD. Cardiac beta-adrenergic signaling: from subcellular microdomains to heart failure. Annals of the New York Academy of Sciences. 1080: 348-61. PMID 17132794 DOI: 10.1196/Annals.1380.026  1
2006 Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12923-8. PMID 16905651 DOI: 10.1073/Pnas.0600137103  1
2005 Erdemir A, Saucerman JJ, Lemmon D, Loppnow B, Turso B, Ulbrecht JS, Cavanagh PR. Local plantar pressure relief in therapeutic footwear: design guidelines from finite element models. Journal of Biomechanics. 38: 1798-806. PMID 16023466 DOI: 10.1016/J.Jbiomech.2004.09.009  1
2005 Michailova A, Saucerman J, Belik ME, McCulloch AD. Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+. Biophysical Journal. 88: 2234-49. PMID 15738467 DOI: 10.1529/Biophysj.104.046284  1
2004 Saucerman JJ, Healy SN, Belik ME, Puglisi JL, McCulloch AD. Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue. Circulation Research. 95: 1216-24. PMID 15528464 DOI: 10.1161/01.Res.0000150055.06226.4E  1
2004 Saucerman JJ, McCulloch AD. Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Progress in Biophysics and Molecular Biology. 85: 261-78. PMID 15142747 DOI: 10.1016/J.Pbiomolbio.2004.01.005  1
2003 Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. Modeling beta-adrenergic control of cardiac myocyte contractility in silico. The Journal of Biological Chemistry. 278: 47997-8003. PMID 12972422 DOI: 10.1074/Jbc.M308362200  1
2002 Saucerman JJ, Michailova AP, McCulloch AD. Modeling biochemical networks and excitation-contraction coupling Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 3: 2235-2236.  1
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