Andrew D. McCulloch - Publications

Affiliations: 
Bioengineering University of California, San Diego, La Jolla, CA 
Area:
computational Biology, cardiac

276 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Craine A, Krishnamurthy A, Villongco CT, Vincent K, Krummen DE, Narayan SM, Kerckhoffs RCP, Omens JH, Contijoch F, McCulloch AD. Successful cardiac resynchronization therapy reduces negative septal work in patient-specific models of dyssynchronous heart failure. Plos Computational Biology. 20: e1012150. PMID 39388481 DOI: 10.1371/journal.pcbi.1012150  0.302
2024 Teitgen AE, Hock MT, McCabe KJ, Childers MC, Huber GA, Marzban B, Beard DA, McCammon JA, Regnier M, McCulloch AD. Multiscale modeling shows how 2'-deoxy-ATP rescues ventricular function in heart failure. Proceedings of the National Academy of Sciences of the United States of America. 121: e2322077121. PMID 39172779 DOI: 10.1073/pnas.2322077121  0.335
2024 Craine A, Krishnamurthy A, Villongco CT, Vincent K, Krummen DE, Narayan SM, Kerckhoffs RCP, Omens JH, Contijoch F, McCulloch AD. Successful Cardiac Resynchronization Therapy Reduces Negative Septal Work in Patient-Specific Models of Dyssynchronous Heart Failure. Biorxiv : the Preprint Server For Biology. PMID 38798676 DOI: 10.1101/2024.05.13.593804  0.302
2024 Pankewitz LR, Hustad KG, Govil S, Perry JC, Hegde S, Tang R, Omens JH, Young AA, McCulloch AD, Arevalo HJ. A universal biventricular coordinate system incorporating valve annuli: Validation in congenital heart disease. Medical Image Analysis. 93: 103091. PMID 38301348 DOI: 10.1016/j.media.2024.103091  0.319
2023 Cao S, Buchholz KS, Tan P, Stowe JC, Wang A, Fowler A, Knaus K, Khalilimeybodi A, Zambon AC, Omens JH, Saucerman J, McCulloch AD. Differential Sensitivity to Longitudinal and Transverse Stretch Mediates Transcriptional Responses in Mouse Neonatal Ventricular Myocytes. American Journal of Physiology. Heart and Circulatory Physiology. PMID 38063811 DOI: 10.1152/ajpheart.00562.2023  0.736
2022 Khalilimeybodi A, Riaz M, Campbell SG, Omens JH, McCulloch AD, Qyang Y, Saucerman JJ. Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathy. Journal of Molecular and Cellular Cardiology. 174: 1-14. PMID 36370475 DOI: 10.1016/j.yjmcc.2022.10.006  0.75
2022 Powers JD, Kirkland NJ, Liu C, Razu SS, Fang X, Engler AJ, Chen J, McCulloch AD. Subcellular Remodeling in Filamin C Deficient Mouse Hearts Impairs Myocyte Tension Development during Progression of Dilated Cardiomyopathy. International Journal of Molecular Sciences. 23. PMID 35055055 DOI: 10.3390/ijms23020871  0.312
2021 Ho G, Atwood TF, Bruggeman AR, Moore KL, McVeigh E, Villongco CT, Han FT, Hsu JC, Hoffmayer KS, Raissi F, Lin GY, Schricker A, Woods CE, Cheung JP, Taira AV, ... McCulloch A, et al. Computational ECG mapping and respiratory gating to optimize stereotactic ablative radiotherapy workflow for refractory ventricular tachycardia. Heart Rhythm O2. 2: 511-520. PMID 34667967 DOI: 10.1016/j.hroo.2021.09.001  0.463
2021 McCulloch AD, Grandi E, Saucerman JJ. Computational models of cardiovascular regulatory mechanisms. Journal of Molecular and Cellular Cardiology. 155: 111. PMID 33647311 DOI: 10.1016/j.yjmcc.2021.01.009  0.714
2020 McCabe KJ, Aboelkassem Y, Teitgen AE, Huber GA, McCammon JA, Regnier M, McCulloch AD. Predicting the effects of dATP on cardiac contraction using multiscale modeling of the sarcomere. Archives of Biochemistry and Biophysics. 108582. PMID 32956632 DOI: 10.1016/J.Abb.2020.108582  0.401
2020 Powers JD, Kooiker KB, Mason AB, Teitgen AE, Flint GV, Tardiff JC, Schwartz SD, McCulloch AD, Regnier M, Davis J, Moussavi-Harami F. Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts. Jci Insight. PMID 32931484 DOI: 10.1172/Jci.Insight.142446  0.462
2020 Liu J, Miller K, Ma X, Dewan S, Lawrence N, Whang G, Chung P, McCulloch AD, Chen S. Direct 3D bioprinting of cardiac micro-tissues mimicking native myocardium. Biomaterials. 256: 120204. PMID 32622020 DOI: 10.1016/J.Biomaterials.2020.120204  0.356
2020 Cao S, Aboelkassem Y, Wang A, Valdez-Jasso D, Saucerman JJ, Omens JH, McCulloch AD. Quantification of model and data uncertainty in a network analysis of cardiac myocyte mechanosignalling. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 378: 20190336. PMID 32448062 DOI: 10.1098/Rsta.2019.0336  0.755
2020 Zhang J, Vincent KP, Peter AK, Klos M, Cheng H, Huang SM, Towne JK, Ferng D, Gu Y, Dalton ND, Chan Y, Li R, Peterson KL, Chen J, McCulloch AD, et al. Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does not Alter Ventricular Function. Circulation Research. PMID 32345129 DOI: 10.1161/Circresaha.119.315539  0.404
2020 Carruth ED, Teh I, Schneider JE, McCulloch AD, Omens JH, Frank LR. Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in rats after left ventricular pressure overload. Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society For Cardiovascular Magnetic Resonance. 22: 21. PMID 32241289 DOI: 10.1186/S12968-020-00615-1  0.341
2020 Shah SJ, Borlaug BA, Kitzman DW, McCulloch AD, Blaxall BC, Agarwal R, Chirinos JA, Collins S, Deo RC, Gladwin MT, Granzier H, Hummel SL, Kass DA, Redfield MM, Sam F, et al. Research Priorities for Heart Failure With Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary. Circulation. 141: 1001-1026. PMID 32202936 DOI: 10.1161/Circulationaha.119.041886  0.318
2020 Herum KM, Romaine A, Wang A, Melleby AO, Strand ME, Pacheco J, Braathen B, Dunér P, Tønnessen T, Lunde IG, Sjaastad I, Brakebusch C, McCulloch AD, Gomez MF, Carlson CR, et al. Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin. Journal of the American Heart Association. 9: e013518. PMID 32000579 DOI: 10.1161/Jaha.119.013518  0.424
2020 Teitgen A, McCabe K, Hock M, Regnier M, McCulloch A. A Coupled Electromechanical Myocyte Model to Assess the Effects of 2‐deoxy‐ATP on Contractile Function in the Heart The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06106  0.388
2020 Forsch N, Govil S, Perry JC, Hegde S, Young AA, Omens JH, McCulloch AD. Computational analysis of cardiac structure and function in congenital heart disease: Translating discoveries to clinical strategies Journal of Computational Science. 101211. DOI: 10.1016/J.Jocs.2020.101211  0.331
2020 Cao S, Buchholz K, Tan PM, Aboelkassem Y, Stowe JC, Saucerman JJ, Omens J, McCulloch AD. Analysis of Differential Gene Expression in Response to Anisotropic Stretch using a Systems Model of Cardiac Myocyte Mechanotransduction Biophysical Journal. 118: 459a-460a. DOI: 10.1016/J.Bpj.2019.11.2558  0.753
2019 Aboelkassem Y, Powers JD, McCabe KJ, McCulloch AD. Multiscale Models of Cardiac Muscle Biophysics and Tissue Remodeling in Hypertrophic Cardiomyopathies. Current Opinion in Biomedical Engineering. 11: 35-44. PMID 31886450 DOI: 10.1016/J.Cobme.2019.09.005  0.446
2019 Yoshida K, McCulloch AD, Omens JH, Holmes JW. Predictions of hypertrophy and its regression in response to pressure overload. Biomechanics and Modeling in Mechanobiology. PMID 31813071 DOI: 10.1007/S10237-019-01271-W  0.541
2019 Timmermann V, Edwards AG, Wall ST, Sundnes J, McCulloch AD. Arrhythmogenic Current Generation by Myofilament-Triggered Ca Release and Sarcomere Heterogeneity. Biophysical Journal. PMID 31810659 DOI: 10.1016/J.Bpj.2019.11.009  0.336
2019 Aboelkassem Y, McCabe KJ, Huber GA, Regnier M, McCammon JA, McCulloch AD. A Stochastic Multiscale Model of Cardiac Thin Filament Activation Using Brownian-Langevin Dynamics. Biophysical Journal. PMID 31547973 DOI: 10.1016/J.Bpj.2019.08.003  0.304
2019 Mineroff J, McCulloch AD, Krummen D, Ganapathysubramanian B, Krishnamurthy A. Optimization Framework for Patient-Specific Cardiac Modeling. Cardiovascular Engineering and Technology. PMID 31531820 DOI: 10.1007/S13239-019-00428-Z  0.354
2019 Jæger KH, Edwards AG, McCulloch A, Tveito A. Properties of cardiac conduction in a cell-based computational model. Plos Computational Biology. 15: e1007042. PMID 31150383 DOI: 10.1371/Journal.Pcbi.1007042  0.41
2019 Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M. Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin. Proceedings of the National Academy of Sciences of the United States of America. PMID 31110001 DOI: 10.1073/Pnas.1905028116  0.378
2019 Yang PC, Purawat S, Ieong PU, Jeng MT, DeMarco KR, Vorobyov I, McCulloch AD, Altinas I, Amaro RE, Clancy CE. A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows. Plos Computational Biology. 15: e1006856. PMID 30849072 DOI: 10.1371/Journal.Pcbi.1006856  0.357
2019 Saucerman JJ, Tan PM, Buchholz KS, McCulloch AD, Omens JH. Mechanical regulation of gene expression in cardiac myocytes and fibroblasts. Nature Reviews. Cardiology. PMID 30683889 DOI: 10.1038/S41569-019-0155-8  0.768
2019 Schweis F, Ho G, Mehta I, Villongco CT, Hoffmayer K, Feld G, McCulloch AD, Krummen D. Quantitative P Wave Characteristics During Sinus Rhythm Are Altered By Cavo-Tricuspid Isthmus Ablation Journal of the American College of Cardiology. 73: 553. DOI: 10.1016/S0735-1097(19)31161-1  0.303
2019 Aboelkassem Y, McCabe KJ, Regnier M, Bassingthwaighte JB, McCulloch AD. Predicting Effects of Tropomyosin Stiffness on Cardiac Muscle Contraction Using Coarse-Grained Stochastic Modeling Biophysical Journal. 116: 115a. DOI: 10.1016/J.Bpj.2018.11.647  0.351
2019 Yuan C, Powers JD, McCabe KJ, Murray JD, Saffie M, Romi C, Carla Z, Ma W, McCulloch AD, Irving TC, Regnier M. Enhanced Crossbridge Binding with 2-Deoxy-ATP Results from Increased Electrostatic Interactions between Myosin and Actin in Cardiac Muscle Biophysical Journal. 116: 466a. DOI: 10.1016/J.Bpj.2018.11.2518  0.317
2018 Tyan L, Foell JD, Vincent KP, Woon MT, Mesquitta WT, Lang D, Best JM, Ackerman MJ, McCulloch AD, Glukhov AV, Balijepalli RC, Kamp TJ. Long QT syndrome caveolin-3 mutations differentially modulate K 4 and Ca 1.2 channels to contribute to action potential prolongation. The Journal of Physiology. PMID 30588629 DOI: 10.1113/Jp276014  0.331
2018 Ma X, Dewan S, Liu J, Tang M, Miller KL, Yu C, Lawrence N, McCulloch AD, Chen S. 3D printed micro-scale force gauge arrays to improve human cardiac tissue maturation and enable high throughput drug testing. Acta Biomaterialia. PMID 30576862 DOI: 10.1016/J.Actbio.2018.12.026  0.353
2018 Lye TH, Vincent KP, McCulloch AD, Hendon CP. Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography. Biophysical Journal. 114: 1477-1489. PMID 29590604 DOI: 10.1016/J.Bpj.2018.01.035  0.321
2018 Cranford JP, O'Hara TJ, Villongco CT, Hafez OM, Blake RC, Loscalzo J, Fattebert JL, Richards DF, Zhang X, Glosli JN, McCulloch AD, Krummen DE, Lightstone FC, Wong SE. Efficient Computational Modeling of Human Ventricular Activation and Its Electrocardiographic Representation: A Sensitivity Study. Cardiovascular Engineering and Technology. PMID 29549620 DOI: 10.1007/S13239-018-0347-0  0.379
2018 Lewalle A, Land S, Carruth E, Frank LR, Lamata P, Omens JH, McCulloch AD, Niederer SA, Smith NP. Decreasing Compensatory Ability of Concentric Ventricular Hypertrophy in Aortic-Banded Rat Hearts. Frontiers in Physiology. 9: 37. PMID 29527171 DOI: 10.3389/Fphys.2018.00037  0.451
2018 Gilbert K, Forsch N, Hegde S, Mauger C, Omens JH, Perry JC, Pontré B, Suinesiaputra A, Young AA, McCulloch AD. Atlas-Based Computational Analysis of Heart Shape and Function in Congenital Heart Disease. Journal of Cardiovascular Translational Research. PMID 29294215 DOI: 10.1007/S12265-017-9778-5  0.392
2018 McCabe KJ, Aboelkassem Y, Dewan S, Regnier M, McCulloch AD. A Markov State Model of the Sarcomere to Explain the Effects of DATP on Cardiac Contraction Biophysical Journal. 114: 541a. DOI: 10.1016/J.Bpj.2017.11.2955  0.391
2018 Aboelkassem Y, McCabe KJ, Huber G, Sundnes J, McCulloch AD. Turning the Azimuthal Motions of Adjacent Tropomyosins into a Coupled N-body Problem in a Brownian Model of Cardiac Thin Filament Activation Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2747  0.316
2017 Erdemir A, Hunter PJ, Holzapfel GA, Loew LM, Middleton J, Jacobs CR, Nithiarasu P, Lohner R, Wei G, Winkelstein BA, Barocas VH, Guilak F, Ku J, Hicks JL, Delp S, ... ... McCulloch AD, et al. Perspectives on Sharing Models and Related Resources in Computational Biomechanics Research. Journal of Biomechanical Engineering. PMID 29247253 DOI: 10.1115/1.4038768  0.499
2017 Tan PM, Buchholz KS, Omens JH, McCulloch AD, Saucerman JJ. Predictive model identifies key network regulators of cardiomyocyte mechano-signaling. Plos Computational Biology. 13: e1005854. PMID 29131824 DOI: 10.1371/Journal.Pcbi.1005854  0.757
2017 Timmermann V, Dejgaard LA, Haugaa KH, Edwards AG, Sundnes J, McCulloch AD, Wall ST. An integrative appraisal of mechano-electric feedback mechanisms in the heart. Progress in Biophysics and Molecular Biology. PMID 28851517 DOI: 10.1016/J.Pbiomolbio.2017.08.008  0.451
2017 Ho G, Villongco CT, Yousefian O, Bradshaw A, Nguyen A, Faiwiszewski Y, Hayase J, Rappel WJ, McCulloch AD, Krummen DE. Rotors exhibit greater Surface ECG variation during ventricular fibrillation than focal sources due to wavebreak, secondary rotors, and meander. Journal of Cardiovascular Electrophysiology. PMID 28670858 DOI: 10.1111/Jce.13283  0.343
2017 Herum KM, Lunde IG, McCulloch AD, Christensen G. The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart. Journal of Clinical Medicine. 6. PMID 28534817 DOI: 10.3390/Jcm6050053  0.433
2017 Herum KM, Choppe J, Kumar A, Engler AJ, McCulloch AD. Mechanical regulation of cardiac fibroblast pro-fibrotic phenotypes. Molecular Biology of the Cell. PMID 28468977 DOI: 10.1091/Mbc.E17-01-0014  0.428
2017 Dewan S, McCabe KJ, Regnier M, McCulloch AD. Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype. Frontiers in Physiology. 8: 151. PMID 28352236 DOI: 10.3389/Fphys.2017.00151  0.375
2017 Dewan S, Krishnamurthy A, Kole D, Conca G, Kerckhoffs R, Puchalski MD, Omens JH, Sun H, Nigam V, McCulloch AD. Model of Human Fetal Growth in Hypoplastic Left Heart Syndrome: Reduced Ventricular Growth Due to Decreased Ventricular Filling and Altered Shape. Frontiers in Pediatrics. 5: 25. PMID 28275592 DOI: 10.3389/Fped.2017.00025  0.376
2017 McCulloch AD. Systems Mechanobiology of Cardiac Myocytes Biophysical Journal. 112: 180a. DOI: 10.1016/J.Bpj.2016.11.998  0.398
2016 Farrar G, Suinesiaputra A, Gilbert K, Perry JC, Hegde S, Marsden A, Young AA, Omens JH, McCulloch AD. Atlas-Based Ventricular Shape Analysis for Understanding Congenital Heart Disease. Progress in Pediatric Cardiology. 43: 61-69. PMID 28082823 DOI: 10.1016/J.Ppedcard.2016.07.010  0.38
2016 Villongco CT, Krummen DE, Omens JH, McCulloch AD. Non-invasive, model-based measures of ventricular electrical dyssynchrony for predicting CRT outcomes. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 18: iv104-iv112. PMID 28011837 DOI: 10.1093/Europace/Euw356  0.393
2016 Carruth ED, McCulloch AD, Omens JH. Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload. Progress in Biophysics and Molecular Biology. PMID 27845176 DOI: 10.1016/J.Pbiomolbio.2016.11.004  0.389
2016 Yang PC, Boras BW, Jeng MT, Docken SS, Lewis TJ, McCulloch AD, Harvey RD, Clancy CE. A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation. Plos Computational Biology. 12: e1005005. PMID 27409243 DOI: 10.1371/Journal.Pcbi.1005005  0.372
2016 Suinesiaputra A, McCulloch AD, Nash MP, Pontre B, Young AA. Cardiac image modelling: Breadth and depth in heart disease. Medical Image Analysis. PMID 27349830 DOI: 10.1016/J.Media.2016.06.027  0.393
2016 Krishnamurthy A, Gonzales MJ, Sturgeon G, Segars WP, McCulloch AD. Biomechanics Simulations Using Cubic Hermite Meshes with Extraordinary Nodes for Isogeometric Cardiac Modeling. Computer Aided Geometric Design. 43: 27-38. PMID 27182096 DOI: 10.1016/J.Cagd.2016.02.016  0.332
2016 Cheng Y, Lindert S, Oxenford L, Tu AY, McCulloch AD, Regnier M. The Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation. The Journal of Physical Chemistry. B. PMID 27150586 DOI: 10.1021/Acs.Jpcb.6B01859  0.349
2016 Zhang Y, Barocas VH, Berceli SA, Clancy CE, Eckmann DM, Garbey M, Kassab GS, Lochner DR, McCulloch AD, Tran-Son-Tay R, Trayanova NA. Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. Annals of Biomedical Engineering. PMID 27138523 DOI: 10.1007/S10439-016-1628-0  0.333
2016 Dewan S, McCabe KJ, Regnier M, McCulloch AD, Lindert S. Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation - An Integrated Multi-Scale Modeling Study. The Journal of Physical Chemistry. B. PMID 27133568 DOI: 10.1021/Acs.Jpcb.6B01950  0.364
2016 Mezzano V, Liang Y, Wright AT, Lyon RC, Pfeiffer E, Song MY, Gu Y, Dalton ND, Scheinman M, Peterson KL, Evans SM, Fowler S, Cerrone M, McCulloch AD, Sheikh F. Desmosomal Junctions Are Necessary for Adult Sinus Node Function. Cardiovascular Research. PMID 27097650 DOI: 10.1093/Cvr/Cvw083  0.53
2016 Schilling JM, Horikawa YT, Zemljic-Harpf AE, Vincent KP, Tyan L, Yu JK, McCulloch AD, Balijepalli RC, Patel HH, Roth DM. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Research in Cardiology. 111: 28. PMID 27023865 DOI: 10.1007/S00395-016-0542-9  0.39
2016 Lye T, Vincent K, McCulloch A, Hendon CP. Normal and Radiofrequency Ablated Atrial Models Enabled by Optical Coherence Tomography Tissue Characterization Biomedical Optics. DOI: 10.1364/Ots.2016.Oth2B.3  0.307
2016 Ortiz A, Suinesiaputra A, Young A, Farrar GE, Printz BF, Omens J, McCulloch AD, Perry JC, Hegde S. Left ventricular shape variation in patients with aortic coarctation pre- and post-stent implantation Journal of Cardiovascular Magnetic Resonance. 18. DOI: 10.1186/1532-429X-18-S1-P186  0.39
2016 Suinesiaputra A, Farrar GE, Gilbert K, Hegde S, McCulloch AD, Omens J, Perry JC, Young A. Application of Atlas-based global shape and local contraction analysis to single-ventricle congenital heart disease Journal of Cardiovascular Magnetic Resonance. 18. DOI: 10.1186/1532-429X-18-S1-P154  0.341
2016 Yang P, Boras B, Jeng M, Docken S, Lewis T, McCulloch A, Harvey R, Clancy C. A Computational Investigation Predicts Mechanisms of Subcellular cAMP Compartmentation Biophysical Journal. 110: 590a. DOI: 10.1016/J.Bpj.2015.11.3151  0.373
2016 Cheng Y, Steffen L, Tu A, Razumova MV, Xie L, Oxenford L, McCulloch AD, McCammon JA, Regnier M. HCM Associated Cardiac Troponin I Mutations Alter Cardiac Troponin Function, Contractile Properties and Modulation by PKA Mediated Phosphorylation Biophysical Journal. 110: 465a. DOI: 10.1016/J.Bpj.2015.11.2487  0.373
2015 de Oliveira BL, Pfeiffer ER, Sundnes J, Wall ST, McCulloch AD. Increased cell membrane capacitance is the dominant mechanism of stretch-dependent conduction slowing in the rabbit heart: a computational study. Cellular and Molecular Bioengineering. 8: 237-246. PMID 27087858 DOI: 10.1007/S12195-015-0384-9  0.44
2015 Aung A, Bhullar IS, Theprungsirikul J, Davey SK, Lim HL, Chiu YJ, Ma X, Dewan S, Lo YH, McCulloch A, Varghese S. 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout. Lab On a Chip. PMID 26588203 DOI: 10.1039/C5Lc00820D  0.366
2015 Sanna MG, Vincent KP, Repetto E, Nhan N, Brown SJ, Abgaryan L, Riley SW, Leaf NB, Cahalan SM, Kiosses WB, Kohno Y, Heller Brown J, McCulloch AD, Rosen H, Gonzalez-Cabrera PJ. Bitopic S1P3 Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction. Molecular Pharmacology. PMID 26494861 DOI: 10.1124/Mol.115.100222  0.397
2015 Boras BW, Hirakis SP, Votapka LW, Malmstrom RD, Amaro RE, McCulloch AD. Bridging scales through multiscale modeling: a case study on protein kinase A. Frontiers in Physiology. 6: 250. PMID 26441670 DOI: 10.3389/Fphys.2015.00250  0.322
2015 Cheng Y, Rao V, Tu AY, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M. Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation. The Journal of Biological Chemistry. 290: 27749-66. PMID 26391394 DOI: 10.1074/Jbc.M115.683045  0.385
2015 Vincent KP, Gonzales MJ, Gillette AK, Villongco CT, Pezzuto S, Omens JH, Holst MJ, McCulloch AD. High-order finite element methods for cardiac monodomain simulations. Frontiers in Physiology. 6: 217. PMID 26300783 DOI: 10.3389/Fphys.2015.00217  0.338
2015 Suarez SL, Rane AA, Muñoz A, Wright AT, Zhang SX, Braden RL, Almutairi A, McCulloch AD, Christman KL. Intramyocardial injection of hydrogel with high interstitial spread does not impact action potential propagation. Acta Biomaterialia. PMID 26265060 DOI: 10.1016/J.Actbio.2015.08.004  0.555
2015 Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. Journal of Molecular and Cellular Cardiology. PMID 26241847 DOI: 10.1016/J.Yjmcc.2015.07.030  0.494
2015 Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG. Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proceedings of the National Academy of Sciences of the United States of America. 112: 10425-30. PMID 26240367 DOI: 10.1073/Pnas.1507486112  0.36
2015 Henney A, Hunter P, McCulloch A, Noble D. Multi-bio and multi-scale systems biology. Progress in Biophysics and Molecular Biology. 117: 1-3. PMID 25783046 DOI: 10.1016/J.Pbiomolbio.2015.03.001  0.549
2015 Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes Journal of Molecular and Cellular Cardiology. DOI: 10.1016/j.yjmcc.2015.07.030  0.356
2015 Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. Ranolazine Prevents Phase-3 Early Afterdepolarizations in Human Atrial Myocytes by Inhibiting Na Current Non-Equilibrium Reactivation Biophysical Journal. 108: 195a-196a. DOI: 10.1016/J.Bpj.2014.11.1080  0.531
2014 Gonzales MJ, Vincent KP, Rappel WJ, Narayan SM, McCulloch AD. Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 16: iv3-iv10. PMID 25362167 DOI: 10.1093/Europace/Euu251  0.3
2014 Cheng Y, Lindert S, Kekenes-Huskey P, Rao VS, Solaro RJ, Rosevear PR, Amaro R, McCulloch AD, McCammon JA, Regnier M. Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics. Biophysical Journal. 107: 1675-85. PMID 25296321 DOI: 10.1016/J.Bpj.2014.08.008  0.331
2014 Pfeiffer ER, Wright AT, Edwards AG, Stowe JC, McNall K, Tan J, Niesman I, Patel HH, Roth DM, Omens JH, McCulloch AD. Caveolae in ventricular myocytes are required for stretch-dependent conduction slowing. Journal of Molecular and Cellular Cardiology. 76: 265-74. PMID 25257915 DOI: 10.1016/J.Yjmcc.2014.09.014  0.579
2014 Edwards AG, Grandi E, Hake JE, Patel S, Li P, Miyamoto S, Omens JH, Heller Brown J, Bers DM, McCulloch AD. Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle. Circulation. Arrhythmia and Electrophysiology. 7: 1205-13. PMID 25236710 DOI: 10.1161/Circep.113.001666  0.53
2014 Rao V, Cheng Y, Lindert S, Wang D, Oxenford L, McCulloch AD, McCammon JA, Regnier M. PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils. Biophysical Journal. 107: 1196-204. PMID 25185555 DOI: 10.1016/J.Bpj.2014.07.027  0.342
2014 Vincent KP, McCulloch AD, Edwards AG. Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia. Frontiers in Pharmacology. 5: 110. PMID 24994983 DOI: 10.3389/Fphar.2014.00110  0.408
2014 Tangney JR, Campbell SG, McCulloch AD, Omens JH. Timing and magnitude of systolic stretch affect myofilament activation and mechanical work. American Journal of Physiology. Heart and Circulatory Physiology. 307: H353-60. PMID 24878774 DOI: 10.1152/Ajpheart.00233.2014  0.374
2014 Hohendanner F, McCulloch AD, Blatter LA, Michailova AP. Calcium and IP3 dynamics in cardiac myocytes: experimental and computational perspectives and approaches. Frontiers in Pharmacology. 5: 35. PMID 24639654 DOI: 10.3389/Fphar.2014.00035  0.302
2014 Banerjee I, Zhang J, Moore-Morris T, Pfeiffer E, Buchholz KS, Liu A, Ouyang K, Stroud MJ, Gerace L, Evans SM, McCulloch A, Chen J. Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response. Plos Genetics. 10: e1004114. PMID 24586179 DOI: 10.1371/Journal.Pgen.1004114  0.344
2014 Hake J, Kekenes-Huskey PM, McCulloch AD. Computational modeling of subcellular transport and signaling. Current Opinion in Structural Biology. 25: 92-7. PMID 24509246 DOI: 10.1016/J.Sbi.2014.01.006  0.347
2014 Morotti S, Edwards AG, McCulloch AD, Bers DM, Grandi E. A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. The Journal of Physiology. 592: 1181-97. PMID 24421356 DOI: 10.1113/Jphysiol.2013.266676  0.473
2014 Pfeiffer ER, Tangney JR, Omens JH, McCulloch AD. Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback. Journal of Biomechanical Engineering. 136: 021007. PMID 24337452 DOI: 10.1115/1.4026221  0.445
2014 Lyon RC, Mezzano V, Wright AT, Pfeiffer E, Chuang J, Banares K, Castaneda A, Ouyang K, Cui L, Contu R, Gu Y, Evans SM, Omens JH, Peterson KL, McCulloch AD, et al. Connexin defects underlie arrhythmogenic right ventricular cardiomyopathy in a novel mouse model. Human Molecular Genetics. 23: 1134-50. PMID 24108106 DOI: 10.1093/Hmg/Ddt508  0.578
2014 Sundnes J, Wall S, Osnes H, Thorvaldsen T, McCulloch AD. Improved discretisation and linearisation of active tension in strongly coupled cardiac electro-mechanics simulations. Computer Methods in Biomechanics and Biomedical Engineering. 17: 604-15. PMID 22800534 DOI: 10.1080/10255842.2012.704368  0.38
2014 Kekenes-Huskey PM, Edwards A, Hake J, Michailova A, McCammon JA, McCulloch A. A Markov-State Model for the Regulation of the Sarcoplasmic Reticulum Ca2+ ATPase by Phospholamban Biophysical Journal. 106: 116a. DOI: 10.1016/J.Bpj.2013.11.702  0.314
2014 Cheng Y, Rao VS, Razumova MV, Tu A, Xie L, Luo Z(, McCammon JA, McCulloch A, Regnier M. The Mechanism of HCM-Related Mutation R21C on the Modulation of C-I Interactions and Contractile Kinetics Biophysical Journal. 106: 726a. DOI: 10.1016/J.Bpj.2013.11.4008  0.34
2014 Pfeiffer E, Wright A, Edwards A, Stowe J, McNall K, Tan J, Patel H, Omens J, McCulloch A. Myocyte Stretch Slows Cardiac Conduction by a Caveolae-Dependent Increase in Sarcolemmal Capacitance Biophysical Journal. 106: 630a. DOI: 10.1016/J.Bpj.2013.11.3485  0.586
2014 Regnier M, Cheng Y, Kekenes-Huskey P, Lindert S, McCulloch A. Experimental and Computational Approaches to Study Myofilament Structure-Function in Normal and Diseased Muscle Biophysical Journal. 106: 221a. DOI: 10.1016/J.Bpj.2013.11.1292  0.356
2013 Lo YH, Peachey T, Abramson D, McCulloch A, Michailova A. Sensitivity of rabbit ventricular action potential and Ca2+ dynamics to small variations in membrane currents and ion diffusion coefficients Biomed Research International. 2013. PMID 24222910 DOI: 10.1155/2013/565431  0.309
2013 Kekenes-Huskey PM, Liao T, Gillette AK, Hake JE, Zhang Y, Michailova AP, McCulloch AD, McCammon JA. Molecular and subcellular-scale modeling of nucleotide diffusion in the cardiac myofilament lattice. Biophysical Journal. 105: 2130-40. PMID 24209858 DOI: 10.1016/J.Bpj.2013.09.020  0.352
2013 Westenbrink BD, Edwards AG, McCulloch AD, Brown JH. The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias. Expert Opinion On Therapeutic Targets. 17: 889-903. PMID 23789646 DOI: 10.1517/14728222.2013.809064  0.44
2013 Krishnamurthy A, Villongco CT, Chuang J, Frank LR, Nigam V, Belezzuoli E, Stark P, Krummen DE, Narayan S, Omens JH, McCulloch AD, Kerckhoffs RC. Patient-Specific Models of Cardiac Biomechanics. Journal of Computational Physics. 244: 4-21. PMID 23729839 DOI: 10.1016/J.Jcp.2012.09.015  0.448
2013 Howard EJ, Kerckhoffs RC, Vincent KP, Krishnamurthy A, Villongco CT, Mulligan LJ, McCulloch AD, Omens JH. Myofiber prestretch magnitude determines regional systolic function during ectopic activation in the tachycardia-induced failing canine heart. American Journal of Physiology. Heart and Circulatory Physiology. 305: H192-202. PMID 23666676 DOI: 10.1152/Ajpheart.00186.2012  0.376
2013 Gonzales MJ, Sturgeon G, Krishnamurthy A, Hake J, Jonas R, Stark P, Rappel WJ, Narayan SM, Zhang Y, Segars WP, McCulloch AD. A three-dimensional finite element model of human atrial anatomy: new methods for cubic Hermite meshes with extraordinary vertices. Medical Image Analysis. 17: 525-37. PMID 23602918 DOI: 10.1016/J.Media.2013.03.005  0.352
2013 Tang T, Lai NC, Wright AT, Gao MH, Lee P, Guo T, Tang R, McCulloch AD, Hammond HK. Adenylyl cyclase 6 deletion increases mortality during sustained β-adrenergic receptor stimulation. Journal of Molecular and Cellular Cardiology. 60: 60-7. PMID 23587598 DOI: 10.1016/J.Yjmcc.2013.04.005  0.54
2013 Tangney JR, Chuang JS, Janssen MS, Krishnamurthy A, Liao P, Hoshijima M, Wu X, Meininger GA, Muthuchamy M, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Novel role for vinculin in ventricular myocyte mechanics and dysfunction. Biophysical Journal. 104: 1623-33. PMID 23561539 DOI: 10.1016/J.Bpj.2013.02.021  0.428
2013 Kekenes-Huskey PM, Hake J, Edwards AG, Cheng Y, Holst M, Sachse F, Bridge J, Mcculloch A, McCammon JA, Michailova A. Modeling Calcium Dynamics in Rabbit Ventricular Myocytes with Several Realistic T-Tubules Subject to Detubulation Biophysical Journal. 104: 107a. DOI: 10.1016/J.Bpj.2012.11.625  0.304
2013 Rao VS, Lindert S, Wang DD, Kekenes-Huskey P, Cheng Y, McCammon JA, McCulloch A, Arzberger P, Regnier M. Mechanisms of Altered Cardiac Myofibril Relaxation Caused by the Cardiac Troponin-I R145G Mutation Biophysical Journal. 104: 311a. DOI: 10.1016/J.Bpj.2012.11.1728  0.371
2012 Meng P, Irturk A, Kastner R, McCulloch A, Omens J, Wright A. GPU acceleration of optical mapping algorithm for cardiac electrophysiology. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2012: 1558-61. PMID 23366201 DOI: 10.1109/EMBC.2012.6346240  0.404
2012 Kerckhoffs RC, Omens JH, McCulloch AD. Mechanical discoordination increases continuously after the onset of left bundle branch block despite constant electrical dyssynchrony in a computational model of cardiac electromechanics and growth. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 14: v65-v72. PMID 23104917 DOI: 10.1093/Europace/Eus274  0.449
2012 Smith NP, McCulloch AD, Paterson DJ. What can modelling provide to cardiac physiology? The Journal of Physiology. 590: 4401-2. PMID 22988258 DOI: 10.1113/Jphysiol.2012.242578  0.362
2012 Zhang Y, Liang X, Ma J, Jing Y, Gonzales MJ, Villongco C, Krishnamurthy A, Frank LR, Nigam V, Stark P, Narayan SM, McCulloch AD. An atlas-based geometry pipeline for cardiac Hermite model construction and diffusion tensor reorientation. Medical Image Analysis. 16: 1130-41. PMID 22841777 DOI: 10.1016/J.Media.2012.06.005  0.353
2012 Raskin A, Lange S, Banares K, Lyon RC, Zieseniss A, Lee LK, Yamazaki KG, Granzier HL, Gregorio CC, McCulloch AD, Omens JH, Sheikh F. A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics. The Journal of Biological Chemistry. 287: 29273-84. PMID 22778266 DOI: 10.1074/Jbc.M112.372839  0.372
2012 Kerckhoffs RC, Omens J, McCulloch AD. A single strain-based growth law predicts concentric and eccentric cardiac growth during pressure and volume overload. Mechanics Research Communications. 42: 40-50. PMID 22639476 DOI: 10.1016/J.Mechrescom.2011.11.004  0.434
2012 Hake J, Edwards AG, Yu Z, Kekenes-Huskey PM, Michailova AP, McCammon JA, Holst MJ, Hoshijima M, McCulloch AD. Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit. The Journal of Physiology. 590: 4403-22. PMID 22495592 DOI: 10.1113/Jphysiol.2012.227926  0.305
2012 Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, ... ... McCulloch AD, et al. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. The Journal of Clinical Investigation. 122: 1209-21. PMID 22426213 DOI: 10.1172/Jci61134  0.428
2012 Hunt DL, Campbell PH, Zambon AC, Vranizan K, Evans SM, Kuo HC, Yamaguchi KD, Omens JH, McCulloch AD. Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background. Experimental Physiology. 97: 102-14. PMID 21967898 DOI: 10.1113/Expphysiol.2011.060269  0.336
2012 Tangney J, Campbell S, Mulligan L, McCulloch A, Omens J. Timing and Magnitude of Prestretch Strongly Affect Cardiac Muscle Tension Development Biophysical Journal. 102: 145a. DOI: 10.1016/J.Bpj.2011.11.795  0.373
2012 Janssen MS, Tangney JR, Liao P, Zemljic-Harpf A, Chuang J, Hoshijima M, McCulloch AD, Ross RS, Omens JH. Role of Vinculin in Ventricular Wall Function Biophysical Journal. 102: 143a. DOI: 10.1016/J.Bpj.2011.11.784  0.413
2012 Kekenes-Huskey PM, Hake J, Cheng Y, Holst M, Sachse FB, Bridge JH, McCulloch A, McCammon JA, Michailova A. Modeling Calcium Dynamics in Realistic Rabbit Ventricular Myocytes with Several Transverse Tubules Biophysical Journal. 102: 102a. DOI: 10.1016/J.Bpj.2011.11.577  0.331
2012 Edwards AG, Hake J, Brown JH, McCulloch AD. βAr-Stimulation Causes EADs but not DADs in Pre-Failure CAMKIIδC Transgenic Myocytes Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.559  0.332
2012 Gonzales M, Vincent K, Sturgeon G, Segars P, Narayan SM, McCulloch AD. Construction of Topologically Complex Patient-Specific Cubic Hermite Meshes for the Cardiac Electrophysiology Problem Biophysical Journal. 102: 6-6. DOI: 10.1016/J.Bpj.2011.11.3676  0.345
2012 Gonzales MJ, McCulloch AD, Narayan SM. Atrial Fibrillation Initiation in a Patient-Specific Cubic Hermite Mesh Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3675  0.333
2012 Wright AT, Niesman IR, Roth DM, Patel HH, Omens JH, McCulloch AD. The Role of Caveolae and Membrane Conformation in Load-Induced Ventricular Conduction Slowing Biophysical Journal. 102: 542a-543a. DOI: 10.1016/J.Bpj.2011.11.2961  0.556
2012 Boras BW, McCulloch A. Subcellular Modeling of PKA Activation and cAMP Diffusion in Localized Microdomains of Adult Cardiomyocytes Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2800  0.319
2012 Pfeiffer E, Murienne B, Stowe J, McNall K, Wright A, McCulloch A. Anisotropic Biaxial Stretch Slows Longitudinal and Transverse Conduction in Micropatterned Mouse Ventricular Myocyte Cultures Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.220  0.516
2012 Nogal NS, Holt KC, Hsia A, Omens JH, McCulloch AD. The Effect of Hypoxia on Mechanical Stretch-Activated Hypertrophic Gene Expression in Neonatal Mouse Ventricular Cardiomyocytes Biophysical Journal. 102: 354a. DOI: 10.1016/J.Bpj.2011.11.1935  0.361
2012 Krishnamurthy A, Villongco C, Kerckhoffs R, McCulloch A. Multi-Scale Modeling of Patient-Specific Ventricular Geometry, Fiber Structure, and Biomechanics Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1924  0.433
2011 Campbell SG, McCulloch AD. Multi-scale computational models of familial hypertrophic cardiomyopathy: genotype to phenotype. Journal of the Royal Society, Interface / the Royal Society. 8: 1550-61. PMID 21831889 DOI: 10.1098/Rsif.2011.0184  0.455
2011 Howard EJ, Covell JW, Mulligan LJ, McCulloch AD, Omens JH, Kerckhoffs RC. Improvement in pump function with endocardial biventricular pacing increases with activation time at the left ventricular pacing site in failing canine hearts. American Journal of Physiology. Heart and Circulatory Physiology. 301: H1447-55. PMID 21784986 DOI: 10.1152/Ajpheart.00295.2011  0.403
2011 Aguado-Sierra J, Krishnamurthy A, Villongco C, Chuang J, Howard E, Gonzales MJ, Omens J, Krummen DE, Narayan S, Kerckhoffs RC, McCulloch AD. Patient-specific modeling of dyssynchronous heart failure: a case study. Progress in Biophysics and Molecular Biology. 107: 147-55. PMID 21763714 DOI: 10.1016/J.Pbiomolbio.2011.06.014  0.435
2011 Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, ... ... McCulloch AD, et al. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Progress in Biophysics and Molecular Biology. 107: 4-10. PMID 21745496 DOI: 10.1016/J.Pbiomolbio.2011.07.001  0.643
2011 Tveito A, Lines GT, Li P, McCulloch A. Defining candidate drug characteristics for long-QT (LQT3) syndrome Mathematical Biosciences and Engineering. 8: 861-873. PMID 21675815 DOI: 10.3934/Mbe.2011.8.861  0.336
2011 Hake J, Louch WE, Haugen K, Sjaastad I, Sejersted OM, McCulloch A, Michailova A, Lines GT. A Stochastic Model of the Ryanodine Receptor Featuring Coupled Gating and Competitive Binding of Luminal and Cytosolic Ca2+ and Mg2+ Biophysical Journal. 100: 556a. DOI: 10.1016/J.Bpj.2010.12.3233  0.356
2010 Cheng Y, Yu Z, Hoshijima M, Holst MJ, McCulloch AD, McCammon JA, Michailova AP. Numerical analysis of Ca2+ signaling in rat ventricular myocytes with realistic transverse-axial tubular geometry and inhibited sarcoplasmic reticulum. Plos Computational Biology. 6: e1000972. PMID 21060856 DOI: 10.1371/Journal.Pcbi.1000972  0.303
2010 Chuang JS, Zemljic-Harpf A, Ross RS, Frank LR, McCulloch AD, Omens JH. Determination of three-dimensional ventricular strain distributions in gene-targeted mice using tagged MRI. Magnetic Resonance in Medicine. 64: 1281-8. PMID 20981782 DOI: 10.1002/Mrm.22547  0.385
2010 Campbell SG, Lionetti FV, Campbell KS, McCulloch AD. Coupling of adjacent tropomyosins enhances cross-bridge-mediated cooperative activation in a markov model of the cardiac thin filament. Biophysical Journal. 98: 2254-64. PMID 20483334 DOI: 10.1016/J.Bpj.2010.02.010  0.38
2010 Kerckhoffs RC, Omens JH, McCulloch AD, Mulligan LJ. Ventricular dilation and electrical dyssynchrony synergistically increase regional mechanical nonuniformity but not mechanical dyssynchrony: a computational model. Circulation. Heart Failure. 3: 528-36. PMID 20466849 DOI: 10.1161/Circheartfailure.109.862144  0.455
2010 Jacot JG, Kita-Matsuo H, Wei KA, Chen HS, Omens JH, Mercola M, McCulloch AD. Cardiac myocyte force development during differentiation and maturation. Annals of the New York Academy of Sciences. 1188: 121-7. PMID 20201894 DOI: 10.1111/J.1749-6632.2009.05091.X  0.795
2010 Cheng Y, Yu Z, Hoshijima M, Holst M, McCulloch A, McCammon A, Michailova A. Effects of Membrane Calcium Flux Localizations and Realistic T-Tubule Geometry on Cardiac Excitation-Contraction Coupling Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2985  0.351
2010 Meyer GA, McCulloch AD, Ward SR, Lieber RL. Intermediate Filament and Ecm Mechanics Deduced from Desmin Knockout Muscles Biophysical Journal. 98: 545a. DOI: 10.1016/J.Bpj.2009.12.2957  0.3
2009 Kerckhoffs RC, Campbell SG, Flaim SN, Howard EJ, Sierra-Aguado J, Mulligan LJ, McCulloch AD. Multi-scale modeling of excitation-contraction coupling in the normal and failing heart. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 4281-2. PMID 19963818 DOI: 10.1109/IEMBS.2009.5332708  0.796
2009 Kita-Matsuo H, Barcova M, Prigozhina N, Salomonis N, Wei K, Jacot JG, Nelson B, Spiering S, Haverslag R, Kim C, Talantova M, Bajpai R, Calzolari D, Terskikh A, McCulloch AD, et al. Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. Plos One. 4: e5046. PMID 19352491 DOI: 10.1371/Journal.Pone.0005046  0.769
2009 Lu S, Michailova A, Saucerman J, Cheng Y, Yu Z, Kaiser T, Li W, Bank R, Holst M, McCammon J, Hayashi T, Hoshijima M, Arzberger P, McCulloch A. Multiscale modeling in rodent ventricular myocytes. Ieee Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society. 28: 46-57. PMID 19349251 DOI: 10.1109/Memb.2009.931787  0.747
2009 Campbell SG, Howard E, Aguado-Sierra J, Coppola BA, Omens JH, Mulligan LJ, McCulloch AD, Kerckhoffs RC. Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics. Experimental Physiology. 94: 541-52. PMID 19251984 DOI: 10.1113/Expphysiol.2008.044057  0.438
2009 Kerckhoffs RC, McCulloch AD, Omens JH, Mulligan LJ. Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch block. Medical Image Analysis. 13: 362-9. PMID 18675578 DOI: 10.1016/J.Media.2008.06.013  0.414
2009 Campbell SG, McCulloch AD. Role of Strongly-Bound Crossbridges in Cooperative Cardiac Thin Filament Activation Biophysical Journal. 96: 621a. DOI: 10.1016/J.Bpj.2008.12.3283  0.34
2009 Chuang J, Ross R, McCulloch A, Omens J. Vinculin Contributes to the Passive Stiffness of Myocardium Biophysical Journal. 96: 498a-499a. DOI: 10.1016/J.Bpj.2008.12.2573  0.399
2009 Hsieh AL, Wang Y, Ross RS, Berns MW, McCulloch AD. Mechanotransduction in Single Cardiac Myocyte Studied Using Laser Tweezers and FRET Biophysical Journal. 96: 316a. DOI: 10.1016/J.Bpj.2008.12.1582  0.717
2008 Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, ... ... McCulloch AD, et al. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. The Journal of Clinical Investigation. 118: 3870-80. PMID 19033658 DOI: 10.1172/Jci34472  0.335
2008 Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 118: 1202-11. PMID 18779456 DOI: 10.1161/Circulationaha.108.772715  0.548
2008 Mills RW, Narayan SM, McCulloch AD. Mechanisms of conduction slowing during myocardial stretch by ventricular volume loading in the rabbit. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1270-H1278. PMID 18660447 DOI: 10.1152/Ajpheart.00350.2008  0.624
2008 Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu TI, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, Knowlton KU. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. The Journal of Clinical Investigation. 118: 2758-70. PMID 18636119 DOI: 10.1172/Jci34777  0.562
2008 Kerckhoffs RC, Narayan SM, Omens JH, Mulligan LJ, McCulloch AD. Computational modeling for bedside application. Heart Failure Clinics. 4: 371-8. PMID 18598988 DOI: 10.1016/J.Hfc.2008.02.009  0.303
2008 Campbell SG, Flaim SN, Leem CH, McCulloch AD. Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 366: 3361-80. PMID 18593662 DOI: 10.1098/Rsta.2008.0088  0.798
2008 Jacot JG, McCulloch AD, Omens JH. Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes. Biophysical Journal. 95: 3479-87. PMID 18586852 DOI: 10.1529/Biophysj.107.124545  0.35
2008 Michailova A, McCulloch AD. Effects of Mg2+, pH and PCr on cardiac excitation-metabolic coupling. Magnesium Research : Official Organ of the International Society For the Development of Research On Magnesium. 21: 16-28. PMID 18557130 DOI: 10.1684/Mrh.2008.0126  0.358
2008 Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM. A myocardial lineage derives from Tbx18 epicardial cells. Nature. 454: 104-8. PMID 18480752 DOI: 10.1038/Nature06969  0.432
2008 Kerckhoffs RC, Lumens J, Vernooy K, Omens JH, Mulligan LJ, Delhaas T, Arts T, McCulloch AD, Prinzen FW. Cardiac resynchronization: insight from experimental and computational models. Progress in Biophysics and Molecular Biology. 97: 543-61. PMID 18417196 DOI: 10.1016/J.Pbiomolbio.2008.02.024  0.403
2008 Zhang Y, Sekar RB, McCulloch AD, Tung L. Cell cultures as models of cardiac mechanoelectric feedback. Progress in Biophysics and Molecular Biology. 97: 367-82. PMID 18384846 DOI: 10.1016/J.Pbiomolbio.2008.02.017  0.434
2008 Feala JD, Omens JH, Paternostro G, McCulloch AD. Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology. Annals of the New York Academy of Sciences. 1123: 169-77. PMID 18375589 DOI: 10.1196/Annals.1420.019  0.4
2008 Li W, Gurev V, McCulloch AD, Trayanova NA. The role of mechanoelectric feedback in vulnerability to electric shock. Progress in Biophysics and Molecular Biology. 97: 461-78. PMID 18374394 DOI: 10.1016/J.Pbiomolbio.2008.02.020  0.413
2008 Feala JD, Coquin L, Paternostro G, McCulloch AD. Integrating metabolomics and phenomics with systems models of cardiac hypoxia. Progress in Biophysics and Molecular Biology. 96: 209-25. PMID 17870149 DOI: 10.1016/J.Pbiomolbio.2007.07.014  0.395
2007 Flaim SN, McCulloch AD. Acetylcholine-induced shortening of the epicardial action potential duration may increase repolarization gradients and LQT3 arrhythmic risk. Journal of Electrocardiology. 40: S66-9. PMID 17993332 DOI: 10.1016/J.Jelectrocard.2007.06.010  0.796
2007 Zemljic-Harpf AE, Miller JC, Henderson SA, Wright AT, Manso AM, Elsherif L, Dalton ND, Thor AK, Perkins GA, McCulloch AD, Ross RS. Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy. Molecular and Cellular Biology. 27: 7522-37. PMID 17785437 DOI: 10.1128/Mcb.00728-07  0.582
2007 Flaim SN, Giles WR, McCulloch AD. Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: analysis of the I1768V SCN5A mutation. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 4: 768-78. PMID 17556201 DOI: 10.1016/J.Hrthm.2007.02.009  0.785
2007 Coppola BA, Covell JW, McCulloch AD, Omens JH. Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heart. American Journal of Physiology. Heart and Circulatory Physiology. 293: H754-61. PMID 17449547 DOI: 10.1152/Ajpheart.01225.2006  0.356
2007 Costandi PN, McCulloch AD, Omens JH, Frank LR. High-resolution longitudinal MRI of the transition to heart failure. Magnetic Resonance in Medicine. 57: 714-20. PMID 17390366 DOI: 10.1002/Mrm.21182  0.777
2007 Michailova A, Lorentz W, McCulloch A. Modeling transmural heterogeneity of KATP current in rabbit ventricular myocytes American Journal of Physiology - Cell Physiology. 293: C542-C557. PMID 17329404 DOI: 10.1152/Ajpcell.00148.2006  0.335
2007 Kerckhoffs RC, Neal ML, Gu Q, Bassingthwaighte JB, Omens JH, McCulloch AD. Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation. Annals of Biomedical Engineering. 35: 1-18. PMID 17111210 DOI: 10.1007/S10439-006-9212-7  0.412
2007 Ingrassia CM, Usyk TP, Kerckhoffs RCP, McCulloch AD, Costa KD, Holmes JW. Model-based development of four-dimensional wall motion measures Computer Methods in Applied Mechanics and Engineering. 196: 3061-3069. DOI: 10.1016/J.Cma.2006.06.016  0.666
2007 Kerckhoffs R, Neal M, Bassinghtwaighte J, Omens J, McCulloch A. Ventricular interaction quantified with a novel multi-scale cardiovascular model Pamm. 7: 1141201-1141201. DOI: 10.1002/Pamm.200701131  0.419
2006 Saucerman JJ, McCulloch AD. Cardiac beta-adrenergic signaling: from subcellular microdomains to heart failure. Annals of the New York Academy of Sciences. 1080: 348-61. PMID 17132794 DOI: 10.1196/Annals.1380.026  0.763
2006 Lorenzen-Schmidt I, Schmid-Schönbein GW, Giles WR, McCulloch AD, Chien S, Omens JH. Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear. Cell Biochemistry and Biophysics. 46: 113-22. PMID 17012753 DOI: 10.1385/Cbb:46:2:113  0.308
2006 Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12923-8. PMID 16905651 DOI: 10.1073/Pnas.0600137103  0.755
2006 Costandi PN, Frank LR, McCulloch AD, Omens JH. Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation. American Journal of Physiology. Heart and Circulatory Physiology. 291: H2971-9. PMID 16861693 DOI: 10.1152/Ajpheart.00571.2006  0.783
2006 Flaim SN, Giles WR, McCulloch AD. Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 291: H2617-29. PMID 16829642 DOI: 10.1152/Ajpheart.00350.2006  0.786
2006 McCulloch AD, Omens JH. Myocyte shearing, myocardial sheets, and microtubules. Circulation Research. 98: 1-3. PMID 16397149 DOI: 10.1161/01.Res.0000200395.82480.8D  0.424
2006 Hunter PJ, Li WW, McCulloch AD, Noble D. Multiscale modeling: Physiome project standards, tools, and databases Computer. 39: 48-54. DOI: 10.1109/Mc.2006.392  0.574
2006 Kerckhoffs R, Bordachar P, Healy S, Omens J, McCulloch A. Myocardial mechanics during epicardial versus endocardial left ventricular pacing: simulations and experiments Journal of Biomechanics. 39: S291-S292. DOI: 10.1016/S0021-9290(06)84130-8  0.359
2006 Kerckhoffs R, Gu Q, Omens J, McCulloch A. Ventricular-vascular coupling in numerical models of cardiac electromechanics Journal of Biomechanics. 39: S286. DOI: 10.1016/S0021-9290(06)84104-7  0.403
2006 Mills R, Narayan S, McCulloch A. Cellular mechanisms of cardiac action potential conduction slowing by myocardial strain Journal of Biomechanics. 39: S279. DOI: 10.1016/S0021-9290(06)84075-3  0.652
2005 Healy SN, McCulloch AD. An ionic model of stretch-activated and stretch-modulated currents in rabbit ventricular myocytes. Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups On Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. 7: 128-34. PMID 16102510 DOI: 10.1016/J.Eupc.2005.03.019  0.358
2005 McCulloch AD, Paternostro G. Cardiac systems biology. Annals of the New York Academy of Sciences. 1047: 283-95. PMID 16093504 DOI: 10.1196/Annals.1341.025  0.348
2005 Camelliti P, McCulloch AD, Kohl P. Microstructured cocultures of cardiac myocytes and fibroblasts: a two-dimensional in vitro model of cardiac tissue. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 11: 249-59. PMID 16060978 DOI: 10.1017/S1431927605050506  0.42
2005 Lorenzen-Schmidt I, McCulloch AD, Omens JH. Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling. Annals of Biomedical Engineering. 33: 888-96. PMID 16060528 DOI: 10.1007/S10439-005-3604-Y  0.325
2005 Lorenzen-Schmidt I, Stuyvers BD, ter Keurs HE, Date MO, Hoshijima M, Chien KR, McCulloch AD, Omens JH. Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 39: 241-50. PMID 15978612 DOI: 10.1016/J.Yjmcc.2005.05.006  0.397
2005 Weis SM, Zimmerman SD, Shah M, Covell JW, Omens JH, Ross J, Dalton N, Jones Y, Reed CC, Iozzo RV, McCulloch AD. A role for decorin in the remodeling of myocardial infarction. Matrix Biology : Journal of the International Society For Matrix Biology. 24: 313-24. PMID 15949932 DOI: 10.1016/J.Matbio.2005.05.003  0.691
2005 Michailova A, Saucerman J, Belik ME, McCulloch AD. Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+. Biophysical Journal. 88: 2234-49. PMID 15738467 DOI: 10.1529/Biophysj.104.046284  0.739
2005 McCulloch AD, Gallagher JO, Bhatia SN, Borg TK, Omens JH. Three-dimensional micropatterned cardiac tissue cultures Microscopy and Microanalysis. 11: 110-111. DOI: 10.1017/S1431927605509504  0.33
2005 Rao J, Ellisman M, Hakozaki H, Price R, Omens JH, McCulloch AD. Quantification and Representation of Structural Heterogeneities in a Continuum Model of the Mouse Heart Microscopy and Microanalysis. 11. DOI: 10.1017/S1431927605503830  0.38
2005 Saucerman JJ, Zhang J, Stenbit AE, Tsien RY, McCulloch AD. Imaging Protein Kinase A Signaling Dynamics in Live Cardiac Myocytes Microscopy and Microanalysis. 11. DOI: 10.1017/S1431927605502472  0.743
2004 McCulloch AD. Functionally and structurally integrated computational modeling of ventricular physiology. The Japanese Journal of Physiology. 54: 531-9. PMID 15760485 DOI: 10.2170/Jjphysiol.54.531  0.363
2004 Chen L, McCulloch AD, May-Newman K. Nonhomogeneous deformation in the anterior leaflet of the mitral valve. Annals of Biomedical Engineering. 32: 1599-606. PMID 15675673 DOI: 10.1007/S10439-004-7813-6  0.328
2004 Saucerman JJ, Healy SN, Belik ME, Puglisi JL, McCulloch AD. Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue. Circulation Research. 95: 1216-24. PMID 15528464 DOI: 10.1161/01.Res.0000150055.06226.4E  0.772
2004 Michailova AP, Belik ME, McCulloch AD. Effects of magnesium on cardiac excitation-contraction coupling. Journal of the American College of Nutrition. 23: 514S-517S. PMID 15466954 DOI: 10.1080/07315724.2004.10719392  0.36
2004 Buckberg GD, Weisfeldt ML, Ballester M, Beyar R, Burkhoff D, Coghlan HC, Doyle M, Epstein ND, Gharib M, Ideker RE, Ingels NB, LeWinter MM, McCulloch AD, Pohost GM, Reinlib LJ, et al. Left ventricular form and function: scientific priorities and strategic planning for development of new views of disease. Circulation. 110: e333-6. PMID 15466651 DOI: 10.1161/01.Cir.0000143625.56882.5C  0.357
2004 McCulloch AD, Harris AB, Sarraf CE, Eastwood M. New multi-cue bioreactor for tissue engineering of tubular cardiovascular samples under physiological conditions. Tissue Engineering. 10: 565-73. PMID 15165473 DOI: 10.1089/107632704323061924  0.307
2004 Saucerman JJ, McCulloch AD. Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation. Progress in Biophysics and Molecular Biology. 85: 261-78. PMID 15142747 DOI: 10.1016/J.Pbiomolbio.2004.01.005  0.747
2004 Belik ME, Usyk TP, McCulloch AD. Computational Methods for Cardiac Electrophysiology Handbook of Numerical Analysis. 12: 129-187. DOI: 10.1016/S1570-8659(03)12002-9  0.397
2003 Usyk TP, McCulloch AD. Relationship between regional shortening and asynchronous electrical activation in a three-dimensional model of ventricular electromechanics. Journal of Cardiovascular Electrophysiology. 14: S196-202. PMID 14760924 DOI: 10.1046/J.1540.8167.90311.X  0.384
2003 Usyk TP, McCulloch AD. Electromechanical model of cardiac resynchronization in the dilated failing heart with left bundle branch block. Journal of Electrocardiology. 36: 57-61. PMID 14716593 DOI: 10.1016/J.Jelectrocard.2003.09.015  0.454
2003 Omens JH, McCulloch AD, Criscione JC. Complex distributions of residual stress and strain in the mouse left ventricle: experimental and theoretical models. Biomechanics and Modeling in Mechanobiology. 1: 267-77. PMID 14586695 DOI: 10.1007/S10237-002-0021-0  0.342
2003 Saucerman JJ, Brunton LL, Michailova AP, McCulloch AD. Modeling beta-adrenergic control of cardiac myocyte contractility in silico. The Journal of Biological Chemistry. 278: 47997-8003. PMID 12972422 DOI: 10.1074/Jbc.M308362200  0.756
2003 Sung D, Mills RW, Schettler J, Narayan SM, Omens JH, McCulloch AD. Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heart. Journal of Cardiovascular Electrophysiology. 14: 739-49. PMID 12930255 DOI: 10.1046/J.1540-8167.2003.03072.X  0.732
2003 Herrmann KL, McCulloch AD, Omens JH. Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. American Journal of Physiology. Heart and Circulatory Physiology. 284: H1277-84. PMID 12595292 DOI: 10.1152/Ajpheart.00168.2002  0.329
2003 Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoell R, Chien KR, Omens JH, McCulloch AD. Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnology and Bioengineering. 81: 578-87. PMID 12514807 DOI: 10.1002/Bit.10506  0.348
2002 McCulloch AD, Huber G. Integrative biological modelling in silico Novartis Foundation Symposium. 247: 4-25. PMID 12539946 DOI: 10.1002/0470857897.Ch2  0.317
2002 Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, et al. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 111: 943-55. PMID 12507422 DOI: 10.1016/S0092-8674(02)01226-6  0.331
2002 Sussman MA, McCulloch A, Borg TK. Dance band on the Titanic: Biomechanical signaling in cardiac hypertrophy Circulation Research. 91: 888-898. PMID 12433833 DOI: 10.1161/01.Res.0000041680.43270.F8  0.315
2002 Stuyvers BD, McCulloch AD, Guo J, Duff HJ, Ter Keurs HEDJ. Effect of stimulation rate, sarcomere length and Ca2+ on force generation by mouse cardiac muscle Journal of Physiology. 544: 817-830. PMID 12411526 DOI: 10.1113/Jphysiol.2002.024430  0.339
2002 Omens JH, Usyk TP, Li Z, McCulloch AD. Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics. American Journal of Physiology. Heart and Circulatory Physiology. 282: H680-7. PMID 11788418 DOI: 10.1152/Ajpheart.00773.2001  0.445
2002 Usyk TP, LeGrice IJ, McCulloch AD. Computational model of three-dimensional cardiac electromechanics Computing and Visualization in Science. 4: 249-257. DOI: 10.1007/S00791-002-0081-9  0.412
2002 Saucerman JJ, Michailova AP, McCulloch AD. Modeling biochemical networks and excitation-contraction coupling Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 3: 2235-2236.  0.7
2001 Sung D, Somayajula-Jagai J, Cosman P, Mills R, McCulloch AD. Phase shifting prior to spatial filtering enhances optical recordings of cardiac action potential propagation Annals of Biomedical Engineering. 29: 854-861. PMID 11764316 DOI: 10.1114/1.1408927  0.521
2001 Gregersen H, Weis SM, McCulloch AD. Oesophageal morphometry and residual strain in a mouse model of osteogenesis imperfecta. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 13: 457-64. PMID 11696107 DOI: 10.1046/J.1365-2982.2001.00279.X  0.65
2001 McCulloch AD, Mazhari R. Regional myocardial mechanics: Integrative computational models of flow-function relations Journal of Nuclear Cardiology. 8: 506-519. PMID 11481573 DOI: 10.1067/Mnc.2001.117113  0.371
2001 Mazhari R, Omens JH, Pavelec RS, Covell JW, McCulloch AD. Transmural distribution of three-dimensional systolic strains in stunned myocardium Circulation. 104: 336-341. PMID 11457754 DOI: 10.1161/01.Cir.104.3.336  0.317
2001 Usyk TP, Omens JH, McCulloch AD. Regional septal dysfunction in a three-dimensional computational model of focal myofiber disarray American Journal of Physiology - Heart and Circulatory Physiology. 281: H506-H514. PMID 11454551 DOI: 10.1152/Ajpheart.2001.281.2.H506  0.369
2001 Vetter FJ, McCulloch AD. Mechanoelectric feedback in a model of the passively inflated left ventricle Annals of Biomedical Engineering. 29: 414-426. PMID 11400722 DOI: 10.1114/1.1366670  0.397
2001 Paternostro G, Vignola C, Bartsch DU, Omens JH, McCulloch AD, Reed JC. Age-associated cardiac dysfunction in Drosophila melanogaster Circulation Research. 88: 1053-1058. PMID 11375275 DOI: 10.1161/Hh1001.090857  0.354
2001 Arts T, Costa KD, Covell JW, McCulloch AD. Relating myocardial laminar architecture to shear strain and muscle fiber orientation American Journal of Physiology - Heart and Circulatory Physiology. 280: H2222-H2229. PMID 11299225 DOI: 10.1152/Ajpheart.2001.280.5.H2222  0.59
2001 Young AA, Dokos S, Powell KA, Sturm B, McCulloch AD, Starling RC, McCarthy PM, White RD. Regional heterogeneity of function in nonischemic dilated cardiomyopathy Cardiovascular Research. 49: 308-318. PMID 11164841 DOI: 10.1016/S0008-6363(00)00248-0  0.327
2001 Costa KD, Holmes JW, McCulloch AD. Modelling cardiac mechanical properties in three dimensions Philosophical Transactions of the Royal Society a: Mathematical, Physical and Engineering Sciences. 359: 1233-1250. DOI: 10.1098/Rsta.2001.0828  0.638
2001 Sung D, Omens JH, McCulloch AD. Ventricular mechano-electric feedback in the isolated rabbit heart American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 50: 683-684.  0.522
2001 McCulloch AD, Sung D, Thomas ME, Michailova A. Experimental and computational modeling of cardiac electromechanical coupling Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2230: 113-119.  0.53
2000 O'Dell WG, McCulloch AD. Imaging three-dimensional cardiac function Annual Review of Biomedical Engineering. 2: 431-456. PMID 11701519 DOI: 10.1146/Annurev.Bioeng.2.1.431  0.714
2000 Mazhari R, McCulloch AD. Integrative models for understanding the structural basis of regional mechanical dysfunction in ischemic myocardium Annals of Biomedical Engineering. 28: 979-990. PMID 11144683 DOI: 10.1114/1.1308502  0.38
2000 Sung D, Omens JH, McCulloch AD. Model-based analysis of optically mapped epicardial activation patterns and conduction velocity Annals of Biomedical Engineering. 28: 1085-1092. PMID 11132192 DOI: 10.1114/1.1314891  0.545
2000 Weis SM, Emery JL, Becker KD, McBride DJ, Omens JH, McCulloch AD. Myocardial mechanics and collagen structure in the osteogenesis imperfecta murine (oim). Circulation Research. 87: 663-9. PMID 11029401 DOI: 10.1161/01.Res.87.8.663  0.687
2000 Vetter FJ, Mcculloch AD. Three-Dimensional Stress and Strain in Passive Rabbit Left Ventricle: A Model Study Annals of Biomedical Engineering. 28: 781-792. PMID 11016415 DOI: 10.1114/1.1289469  0.347
2000 Mazhari R, Omens JH, Covell JW, McCulloch AD. Structural basis of regional dysfunction in acutely ischemic myocardium Cardiovascular Research. 47: 284-293. PMID 10946065 DOI: 10.1016/S0008-6363(00)00089-4  0.331
2000 Karlon WJ, McCulloch AD, Covell JW, Hunter JJ, Omens JH. Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras American Journal of Physiology - Heart and Circulatory Physiology. 278: H898-H906. PMID 10710359 DOI: 10.1152/Ajpheart.2000.278.3.H898  0.329
2000 Usyk TP, Mazhari R, Mcculloch AD. Effect of laminar orthotropic myofiber architecture on regional stress and strain in the canine left ventricle Journal of Elasticity. 61: 143-164. DOI: 10.1023/A:1010883920374  0.395
1999 Lee AA, Delhaas T, McCulloch AD, Villarreal FJ. Differential responses of adult cardiac fibroblasts to in vitro biaxial strain patterns Journal of Molecular and Cellular Cardiology. 31: 1833-1843. PMID 10525421 DOI: 10.1006/Jmcc.1999.1017  0.385
1999 Costa KD, Takayama Y, McCulloch AD, Covell JW. Laminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium American Journal of Physiology - Heart and Circulatory Physiology. 276: H595-H607. PMID 9950861 DOI: 10.1152/Ajpheart.1999.276.2.H595  0.624
1998 Bluhm WF, Lew WYW, Garfinkel A, McCulloch AD. Mechanisms of length history-dependent tension in an ionic model of the cardiac myocyte. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1032-H1040. PMID 29591247 DOI: 10.1152/ajpheart.1998.274.3.H1032  0.317
1998 Omens JH, Vaplon SM, Fazeli B, McCulloch AD. Left ventricular geometric remodeling and residual stress in the rat heart Journal of Biomechanical Engineering. 120: 715-719. PMID 10412454 DOI: 10.1115/1.2834884  0.375
1998 Summerour SR, Emery JL, Fazeli B, Omens JH, McCulloch AD. Residual strain in ischemic ventricular myocardium Journal of Biomechanical Engineering. 120: 710-714. PMID 10412453 DOI: 10.1115/1.2834883  0.389
1998 Bluhm WF, Sung D, Lew WYW, Garfinkel A, McCulloch AD. Cellular mechanisms for the slow phase of the Frank-Starling response Journal of Electrocardiology. 31: 13-22. PMID 9988000 DOI: 10.1016/S0022-0736(98)90273-4  0.586
1998 May-Newman K, McCulloch AD. Homogenization modeling for the mechanics of perfused myocardium Progress in Biophysics and Molecular Biology. 69: 463-481. PMID 9785951 DOI: 10.1016/S0079-6107(98)00020-0  0.36
1998 Hunter PJ, McCulloch AD, ter Keurs HE. Modelling the mechanical properties of cardiac muscle. Progress in Biophysics and Molecular Biology. 69: 289-331. PMID 9785944 DOI: 10.1016/S0079-6107(98)00013-3  0.574
1998 Vetter FJ, McCulloch AD. Three-dimensional analysis of regional cardiac function: A model of rabbit ventricular anatomy Progress in Biophysics and Molecular Biology. 69: 157-183. PMID 9785937 DOI: 10.1016/S0079-6107(98)00006-6  0.465
1998 McCulloch A, Bassingthwaighte J, Hunter P, Noble D. Computational biology of the heart: from structure to function. Progress in Biophysics and Molecular Biology. 69: 153-5. PMID 9785936 DOI: 10.1016/S0079-6107(98)00005-4  0.641
1998 Gregersen H, Emery JL, Mcculloch AD. History-dependent mechanical behavior of guinea-pig small intestine Annals of Biomedical Engineering. 26: 850-858. PMID 9779958 DOI: 10.1114/1.109  0.302
1998 Mazhari R, Omens JH, Waldman LK, Mcculloch AD. Regional myocardial perfusion and mechanics: A model-based method of analysis Annals of Biomedical Engineering. 26: 743-755. PMID 9779946 DOI: 10.1114/1.74  0.345
1998 McCulloch AD, Sung D, Wilson JM, Pavelec RS, Omens JH. Flow-function relations during graded coronary occlusions in the dog: Effects of transmural location and segment orientation Cardiovascular Research. 37: 636-645. PMID 9659447 DOI: 10.1016/S0008-6363(97)00290-3  0.528
1998 Bluhm WF, Lew WYW, Garfinkel A, McCulloch AD. Mechanisms of length history-dependent tension in an ionic model of the cardiac myocyte American Journal of Physiology - Heart and Circulatory Physiology. 43: H1032-H1040. DOI: 10.1152/Ajpheart.1998.274.3.H1032  0.431
1997 Costa KD, May-Newman K, Farr D, O'Dell WG, McCulloch AD, Omens JH. Three-dimensional residual strain in midanterior canine left ventricle. American Journal of Physiology. Heart and Circulatory Physiology. 273: H1968-H1976. PMID 29586327 DOI: 10.1152/ajpheart.1997.273.4.H1968  0.737
1997 McCulloch AD. Three-dimensional residual strain in midanterior canine left ventricle American Journal of Physiology - Heart and Circulatory Physiology. 273: H1968-H1976. PMID 9362268 DOI: 10.1152/Ajpheart.1997.273.4.H1968  0.321
1997 Lee AA, McCulloch AD. Multiaxial myocardial mechanics and extracellular matrix remodeling: Mechanochemical regulation of cardiac fibroblast function Advances in Experimental Medicine and Biology. 430: 227-240. PMID 9330732 DOI: 10.1007/978-1-4615-5959-7_19  0.399
1997 Emery JL, Omens JH, McCulloch AD. Strain softening in rat left ventricular myocardium Journal of Biomechanical Engineering. 119: 6-12. PMID 9083843 DOI: 10.1115/1.2796067  0.33
1997 Guccione JM, O'Dell WG, McCulloch AD, Hunter WC. Anterior and posterior left ventricular sarcomere lengths behave similarly during ejection. The American Journal of Physiology. 272: H469-77. PMID 9038969 DOI: 10.1152/Ajpheart.1997.272.1.H469  0.728
1997 Mackenna DA, Vaplon SM, Mcculloch AD. Microstructural model of perimysial collagen fibers for resting myocardial mechanics during ventricular filling American Journal of Physiology - Heart and Circulatory Physiology. 42: H1576-H1586. DOI: 10.1152/Ajpheart.1997.273.3.H1576  0.323
1997 Emery JL, Omens JH, McCulloch AD. Biaxial mechanics of the passively overstretched left ventricle American Journal of Physiology - Heart and Circulatory Physiology. 41: H2299-H2305. DOI: 10.1152/Ajpheart.1997.272.5.H2299  0.383
1996 Costa KD, Hunter PJ, Wayne JS, Waldman LK, Guccione JM, McCulloch AD. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: II--Prolate spheroidal coordinates. Journal of Biomechanical Engineering. 118: 464-72. PMID 8950649 DOI: 10.1115/1.2796032  0.675
1996 Costa KD, Hunter PJ, Rogers JM, Guccione JM, Waldman LK, McCulloch AD. A three-dimensional finite element method for large elastic deformations of ventricular myocardium: I--Cylindrical and spherical polar coordinates. Journal of Biomechanical Engineering. 118: 452-63. PMID 8950648 DOI: 10.1115/1.2796031  0.659
1996 Lee AA, Delhaas T, Waldman LK, MacKenna DA, Villarreal FJ, McCulloch AD. An equibiaxial strain system for cultured cells. The American Journal of Physiology. 271: C1400-8. PMID 8897847 DOI: 10.1152/Ajpcell.1996.271.4.C1400  0.308
1996 Omens JH, Farr DD, McCulloch AD, Waldman LK. Comparison of two techniques for measuring two-dimensional strain in rat left ventricles. The American Journal of Physiology. 271: H1256-61. PMID 8853366 DOI: 10.1152/Ajpheart.1996.271.3.H1256  0.403
1996 Waldman LK, Allen JJ, Pavelec RS, McCulloch AD. Distributed mechanics of the canine right ventricle: effects of varying preload. Journal of Biomechanics. 29: 373-81. PMID 8850643 DOI: 10.1016/0021-9290(95)00051-8  0.31
1996 Guccione JM, Costa KD, McCulloch AD. Finite element stress analysis of left ventricular mechanics in the beating dog heart. Journal of Biomechanics. 28: 1167-77. PMID 8550635 DOI: 10.1016/0021-9290(94)00174-3  0.611
1996 Guccione JM, McCulloch AD, Waldman LK. Closure to “Discussion of ‘Passive Material Properties of Intact Ventricular Myocardium Determined From a Cylindrical Model” (1996, ASME J. Biomech. Eng., 118, pp. 262) Journal of Biomechanical Engineering-Transactions of the Asme. 118: 262-263. DOI: 10.1115/1.2795972  0.3
1995 May-Newman K, Mathieu-Costello O, Omens JH, Klumb K, McCulloch AD. Transmural Distribution of Capillary Morphology as a Function of Coronary Perfusion Pressure in the Resting Canine Heart Microvascular Research. 50: 381-396. PMID 8583952 DOI: 10.1006/Mvre.1995.1066  0.322
1995 Lee AA, Dillmann WH, McCulloch AD, Villarreal FJ. Angiotensin II stimulates the autocrine production of transforming growth factor-beta 1 in adult rat cardiac fibroblasts. Journal of Molecular and Cellular Cardiology. 27: 2347-57. PMID 8576949 DOI: 10.1016/S0022-2828(95)91983-X  0.301
1995 Bluhm WF, McCulloch AD, Lew WY. Active force in rabbit ventricular myocytes. Journal of Biomechanics. 28: 1119-22. PMID 7559682 DOI: 10.1016/0021-9290(94)00018-Y  0.321
1994 May-Newman K, Omens JH, Pavelec RS, McCulloch AD. Three-dimensional transmural mechanical interaction between the coronary vasculature and passive myocardium in the dog Circulation Research. 74: 1166-1178. PMID 8187283 DOI: 10.1161/01.Res.74.6.1166  0.367
1994 MacKenna DA, Omens JH, McCulloch AD, Covell JW. Contribution of collagen matrix to passive left ventricular mechanics in isolated rat hearts American Journal of Physiology - Heart and Circulatory Physiology. 266: H1007-H1018. PMID 8160804 DOI: 10.1152/Ajpheart.1994.266.3.H1007  0.357
1994 Rogers JM, McCulloch AD. A Collocation—Galerkin Finite Element Model of Cardiac Action Potential Propagation Ieee Transactions On Biomedical Engineering. 41: 743-757. PMID 7927397 DOI: 10.1109/10.310090  0.33
1994 Van Leuven SL, Waldman LK, McCulloch AD, Covell JW. Gradients of epicardial strain across the perfusion boundary during acute myocardial ischemia. The American Journal of Physiology. 267: H2348-62. PMID 7810735 DOI: 10.1152/Ajpheart.1994.267.6.H2348  0.312
1993 Omens JH, MacKenna DA, McCulloch AD. Measurement of strain and analysis of stress in resting rat left ventricular myocardium Journal of Biomechanics. 26: 665-676. PMID 8514812 DOI: 10.1016/0021-9290(93)90030-I  0.353
1993 Guccione JM, Waldman LK, McCulloch AD. Mechanics of Active Contraction in Cardiac Muscle: Part II—Cylindrical Models of the Systolic Left Ventricle Journal of Biomechanical Engineering-Transactions of the Asme. 115: 82-90. PMID 8445902 DOI: 10.1115/1.2895474  0.428
1993 Guccione JM, McCulloch AD. Mechanics of Active Contraction in Cardiac Muscle: Part I—Constitutive Relations for Fiber Stress That Describe Deactivation Journal of Biomechanical Engineering-Transactions of the Asme. 115: 72-81. PMID 8445901 DOI: 10.1115/1.2895473  0.376
1993 Hashima AR, Young AA, McCulloch AD, Waldman LK. Nonhomogeneous analysis of epicardial strain distributions during acute myocardial ischemia in the dog Journal of Biomechanics. 26: 19-35. PMID 8423166 DOI: 10.1016/0021-9290(93)90610-Q  0.347
1992 McCulloch AD, Hunter PJ, Smaill BH. Mechanical effects of coronary perfusion in the passive canine left ventricle. The American Journal of Physiology. 262: H523-30. PMID 1539711 DOI: 10.1152/Ajpheart.1992.262.2.H523  0.536
1991 Guccione JM, McCulloch AD, Waldman LK. Passive material properties of intact ventricular myocardium determined from a cylindrical model. Journal of Biomechanical Engineering-Transactions of the Asme. 113: 42-55. PMID 2020175 DOI: 10.1115/1.2894084  0.335
1991 Omens JH, May KD, McCulloch AD. Transmural distribution of three-dimensional strain in the isolated arrested canine left ventricle American Journal of Physiology - Heart and Circulatory Physiology. 261: H918-H928. PMID 1887936 DOI: 10.1152/Ajpheart.1991.261.3.H918  0.333
1991 McCulloch AD, Omens JH. Non-homogeneous analysis of three-dimensional transmural finite deformation in canine ventricular myocardium Journal of Biomechanics. 24: 539-548. PMID 1880138 DOI: 10.1016/0021-9290(91)90287-W  0.358
1989 McCulloch AD, Smaill BH, Hunter PJ. Regional left ventricular epicardial deformation in the passive dog heart. Circulation Research. 64: 721-33. PMID 2702734 DOI: 10.1161/01.Res.64.4.721  0.551
1987 McCulloch AD, Smaill BH, Hunter PJ. Left ventricular epicardial deformation in isolated arrested dog heart. The American Journal of Physiology. 252: H233-41. PMID 3812713 DOI: 10.1152/Ajpheart.1987.252.1.H233  0.573
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