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Pengda Liu, Ph.D. - Publications

Affiliations: 
2008 East Carolina University, Greenville, NC, United States 
Area:
Molecular Biology, Cell Biology
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Antonia RJ, Castillo J, Herring LE, Serafin DS, Liu P, Graves LM, Baldwin AS, Hagan RS. TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877. Scientific Reports. 9: 13470. PMID 31530866 DOI: 10.1038/S41598-019-49707-8  0.324
2019 Jiang Y, Zhang Y, Leung JY, Fan C, Popov KI, Su S, Qian J, Wang X, Holtzhausen A, Ubil E, Xiang Y, Davis I, Dokholyan NV, Wu G, Perou CM, ... ... Liu P, et al. MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression. Nature Communications. 10: 1515. PMID 30944303 DOI: 10.1038/S41467-019-09233-7  0.332
2019 Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, et al. Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. PMID 30783264 DOI: 10.1038/S41556-019-0280-Y  0.343
2017 Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, ... ... Liu P, et al. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nature Medicine. PMID 28805820 DOI: 10.1038/Nm.4378  0.355
2017 Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, Guo J, Zhang J, North BJ, Dai X, Cheng X, Bian X, Zhang L, Harper JW, Sun SC, et al. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. PMID 28489822 DOI: 10.1038/Nature22344  0.429
2017 Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, et al. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discovery. PMID 28174173 DOI: 10.1158/2159-8290.Cd-16-0647  0.431
2016 Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, et al. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science (New York, N.Y.). 353: 929-32. PMID 27563096 DOI: 10.1126/Science.Aad5755  0.41
2016 Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Molecular Cell. PMID 27237051 DOI: 10.1016/J.Molcel.2016.04.023  0.434
2015 Kim BM, Hong Y, Lee S, Liu P, Lim JH, Lee YH, Lee TH, Chang KT, Hong Y. Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy. International Journal of Molecular Sciences. 16: 26880-26913. PMID 26569225 DOI: 10.3390/Ijms161125991  0.312
2015 Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W. SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. Molecular Cell. PMID 26344095 DOI: 10.1016/J.Molcel.2015.07.026  0.348
2015 Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5: 1194-209. PMID 26293922 DOI: 10.1158/2159-8290.Cd-15-0460  0.395
2015 Gan W, Liu P, Wei W. Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF. Nucleus (Austin, Tex.). 6: 261-5. PMID 26225792 DOI: 10.1080/19491034.2015.1074365  0.384
2015 Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W. Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair. Molecular Cell. 57: 648-61. PMID 25661488 DOI: 10.1016/J.Molcel.2015.01.005  0.342
2014 Xu K, Liu P, Wei W. mTOR signaling in tumorigenesis. Biochimica Et Biophysica Acta. 1846: 638-54. PMID 25450580 DOI: 10.1016/J.Bbcan.2014.10.007  0.389
2014 Dai X, Liu P, Lau AW, Liu Y, Inuzuka H. Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis. Cancer Medicine. 3: 1211-24. PMID 25116380 DOI: 10.1002/Cam4.298  0.373
2014 Liu P, Wang Z, Wei W. Phosphorylation of Akt at the C-terminal tail triggers Akt activation. Cell Cycle (Georgetown, Tex.). 13: 2162-4. PMID 24933731 DOI: 10.4161/Cc.29584  0.414
2014 Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/Nature13079  0.44
2014 Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W. SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Oncotarget. 5: 1026-37. PMID 24657926 DOI: 10.18632/Oncotarget.1675  0.437
2014 Liu P, Guo J, Gan W, Wei W. Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity. Protein & Cell. 5: 171-7. PMID 24481632 DOI: 10.1007/S13238-014-0021-8  0.449
2013 Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, et al. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. 15: 1340-50. PMID 24161930 DOI: 10.1038/Ncb2860  0.442
2013 Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Reports. 4: 803-16. PMID 23972993 DOI: 10.1016/J.Celrep.2013.07.031  0.382
2013 Lau AW, Inuzuka H, Fukushima H, Wan L, Liu P, Gao D, Sun Y, Wei W. Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Research. 23: 947-61. PMID 23670162 DOI: 10.1038/Cr.2013.67  0.357
2013 Wang Z, Wan L, Zhong J, Inuzuka H, Liu P, Sarkar FH, Wei W. Cdc20: a potential novel therapeutic target for cancer treatment. Current Pharmaceutical Design. 19: 3210-4. PMID 23151139 DOI: 10.2174/1381612811319180005  0.392
2012 Wang Z, Inuzuka H, Zhong J, Liu P, Sarkar FH, Sun Y, Wei W. Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Oncotarget. 3: 1294-300. PMID 23230084 DOI: 10.18632/Oncotarget.740  0.41
2012 Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, Wei W. DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 3: 1026-35. PMID 22976441 DOI: 10.18632/Oncotarget.640  0.378
2012 Wang Z, Zhong J, Gao D, Inuzuka H, Liu P, Wei W. DEPTOR ubiquitination and destruction by SCF(β-TrCP). American Journal of Physiology. Endocrinology and Metabolism. 303: E163-9. PMID 22454292 DOI: 10.1152/Ajpendo.00105.2012  0.317
2012 Wang Z, Fukushima H, Inuzuka H, Wan L, Liu P, Gao D, Sarkar FH, Wei W. Skp2 is a promising therapeutic target in breast cancer. Frontiers in Oncology. 1. PMID 22279619 DOI: 10.3389/Fonc.2011.00057  0.31
2012 Wang Z, Gao D, Fukushima H, Inuzuka H, Liu P, Wan L, Sarkar FH, Wei W. Skp2: a novel potential therapeutic target for prostate cancer. Biochimica Et Biophysica Acta. 1825: 11-7. PMID 21963805 DOI: 10.1016/J.Bbcan.2011.09.002  0.314
2011 Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/J.Molcel.2011.08.030  0.417
2011 Wang Z, Fukushima H, Gao D, Inuzuka H, Wan L, Lau AW, Liu P, Wei W. The two faces of FBW7 in cancer drug resistance. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 33: 851-9. PMID 22006825 DOI: 10.1002/Bies.201100101  0.304
2011 Inuzuka H, Fukushima H, Shaik S, Liu P, Lau AW, Wei W. Mcl-1 ubiquitination and destruction. Oncotarget. 2: 239-44. PMID 21608150 DOI: 10.18632/Oncotarget.242  0.363
2011 Werner-Allen JW, Lee CJ, Liu P, Nicely NI, Wang S, Greenleaf AL, Zhou P. cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. The Journal of Biological Chemistry. 286: 5717-26. PMID 21159777 DOI: 10.1074/Jbc.M110.197129  0.348
2010 Bartkowiak B, Liu P, Phatnani HP, Fuda NJ, Cooper JJ, Price DH, Adelman K, Lis JT, Greenleaf AL. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes & Development. 24: 2303-16. PMID 20952539 DOI: 10.1101/Gad.1968210  0.415
2010 Liu P, Kenney JM, Stiller JW, Greenleaf AL. Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain. Molecular Biology and Evolution. 27: 2628-41. PMID 20558594 DOI: 10.1093/Molbev/Msq151  0.575
2008 Liu P, Greenleaf AL, Stiller JW. The essential sequence elements required for RNAP II carboxyl-terminal domain function in yeast and their evolutionary conservation. Molecular Biology and Evolution. 25: 719-27. PMID 18209193 DOI: 10.1093/Molbev/Msn017  0.604
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