| Year |
Citation |
Score |
| 2015 |
Vardy E, Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V, Stevens RC, Peterson RT, Roth BL. Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chemistry & Biology. 22: 764-75. PMID 26091169 DOI: 10.1016/J.Chembiol.2015.05.012 |
0.398 |
|
| 2013 |
Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Chemotype-selective modes of action of κ-opioid receptor agonists. The Journal of Biological Chemistry. 288: 34470-83. PMID 24121503 DOI: 10.1074/Jbc.M113.515668 |
0.598 |
|
| 2013 |
Elbegdorj O, Westkaemper RB, Zhang Y. A homology modeling study toward the understanding of three-dimensional structure and putative pharmacological profile of the G-protein coupled receptor GPR55. Journal of Molecular Graphics & Modelling. 39: 50-60. PMID 23220281 DOI: 10.1016/J.Jmgm.2012.10.005 |
0.608 |
|
| 2012 |
Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, et al. Structure of the human κ-opioid receptor in complex with JDTic. Nature. 485: 327-32. PMID 22437504 DOI: 10.1038/Nature10939 |
0.591 |
|
| 2010 |
McGovern DL, Mosier PD, Roth BL, Westkaemper RB. CoMFA analyses of C-2 position salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity. Journal of Molecular Graphics & Modelling. 28: 612-25. PMID 20083418 DOI: 10.1016/J.Jmgm.2009.12.008 |
0.347 |
|
| 2010 |
Shah JR, Mosier PD, Peddi S, Roth BL, Westkaemper RB. 9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites. Bioorganic & Medicinal Chemistry Letters. 20: 935-8. PMID 20045641 DOI: 10.1016/J.Bmcl.2009.12.064 |
0.484 |
|
| 2009 |
Shah JR, Mosier PD, Roth BL, Kellogg GE, Westkaemper RB. Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorganic & Medicinal Chemistry. 17: 6496-504. PMID 19700330 DOI: 10.1016/J.Bmc.2009.08.016 |
0.558 |
|
| 2009 |
Yan F, Bikbulatov RV, Mocanu V, Dicheva N, Parker CE, Wetsel WC, Mosier PD, Westkaemper RB, Allen JA, Zjawiony JK, Roth BL. Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. Biochemistry. 48: 6898-908. PMID 19555087 DOI: 10.1021/Bi900605N |
0.558 |
|
| 2009 |
Li G, Aschenbach LC, Chen J, Cassidy MP, Stevens DL, Gabra BH, Selley DE, Dewey WL, Westkaemper RB, Zhang Y. Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists. Journal of Medicinal Chemistry. 52: 1416-27. PMID 19199782 DOI: 10.1021/Jm801272C |
0.617 |
|
| 2009 |
Li G, Aschenbach LC, Chen J, Cassidy MP, Stevens DL, Gabra BH, Selley DE, Dewey WL, Westkaemper RB, Zhang Y. Corrections to design, synthesis, and biological evaluation of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as μ opioid receptor selective antagonists (Journal of Medicinal Chemistry (2009) 52, (1416) DOI 10.1021/jm801272c) Journal of Medicinal Chemistry. 52: 8057. DOI: 10.1021/Jm9016224 |
0.455 |
|
| 2008 |
Runyon SP, Mosier PD, Roth BL, Glennon RA, Westkaemper RB. Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. Journal of Medicinal Chemistry. 51: 6808-28. PMID 18847250 DOI: 10.1021/Jm800771X |
0.604 |
|
| 2008 |
Dewkar GK, Peddi S, Mosier PD, Roth BL, Westkaemper RB. Methoxy-substituted 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives exhibit differential binding affinities at the 5-HT(2A) receptor. Bioorganic & Medicinal Chemistry Letters. 18: 5268-71. PMID 18774714 DOI: 10.1016/J.Bmcl.2008.08.059 |
0.503 |
|
| 2008 |
Yan F, Mosier PD, Westkaemper RB, Roth BL. Galpha-subunits differentially alter the conformation and agonist affinity of kappa-opioid receptors. Biochemistry. 47: 1567-78. PMID 18205395 DOI: 10.1021/Bi701476B |
0.446 |
|
| 2007 |
Vortherms TA, Mosier PD, Westkaemper RB, Roth BL. Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor. The Journal of Biological Chemistry. 282: 3146-56. PMID 17121830 DOI: 10.1074/Jbc.M609264200 |
0.65 |
|
| 2005 |
Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, Roth BL. Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors. Biochemistry. 44: 8643-51. PMID 15952771 DOI: 10.1021/Bi050490D |
0.586 |
|
| 2004 |
Pullagurla MR, Westkaemper RB, Glennon RA. Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors Bioorganic and Medicinal Chemistry Letters. 14: 4569-4573. PMID 15357994 DOI: 10.1016/J.Bmcl.2004.05.076 |
0.527 |
|
| 2004 |
Peddi S, Roth BL, Glennon RA, Westkaemper RB. Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA). Bioorganic & Medicinal Chemistry Letters. 14: 2279-83. PMID 15081025 DOI: 10.1016/J.BMCL.2004.02.014 |
0.454 |
|
| 2003 |
Peddi S, Roth BL, Glennon RA, Westkaemper RB. Spiro[9,10-dihydroanthracene]-9,3'-pyrrolidine-a structurally unique tetracyclic 5-HT2A receptor antagonist. European Journal of Pharmacology. 482: 335-7. PMID 14660041 DOI: 10.1016/J.Ejphar.2003.09.059 |
0.517 |
|
| 2003 |
Peddi S, Roth BL, Glennon RA, Westkaemper RB. Ring substituted analogues of 5-aminomethyl-10,11-dihydro-dibenzo[a,d]cycloheptene (AMDH): potential modes of binding to the 5-HT(2A) receptor. Bioorganic & Medicinal Chemistry Letters. 13: 2565-8. PMID 12852967 DOI: 10.1016/S0960-894X(03)00504-3 |
0.514 |
|
| 2002 |
Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proceedings of the National Academy of Sciences of the United States of America. 99: 11934-9. PMID 12192085 DOI: 10.1073/Pnas.182234399 |
0.574 |
|
| 2002 |
Westkaemper RB, Glennon RA. Application of ligand SAR, receptor modeling and receptor mutagenesis to the discovery and development of a new class of 5-HT(2A) ligands. Current Topics in Medicinal Chemistry. 2: 575-98. PMID 12052195 DOI: 10.2174/1568026023393741 |
0.515 |
|
| 2002 |
Runyon SP, Peddi S, Savage JE, Roth BL, Glennon RA, Westkaemper RB. Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Journal of Medicinal Chemistry. 45: 1656-64. PMID 11931619 DOI: 10.1021/Jm010354G |
0.545 |
|
| 2001 |
Runyon SP, Savage JE, Taroua M, Roth BL, Glennon RA, Westkaemper RB. Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Bioorganic & Medicinal Chemistry Letters. 11: 655-8. PMID 11266163 DOI: 10.1016/S0960-894X(01)00023-3 |
0.562 |
|
| 2001 |
Westkaemper RB, Runyon SP, Savage JE, Roth BL, Glennon RA. Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor. Bioorganic & Medicinal Chemistry Letters. 11: 563-6. PMID 11229772 DOI: 10.1016/S0960-894X(01)00010-5 |
0.607 |
|
| 1999 |
Westkaemper RB, Runyon SP, Bondarev ML, Savage JE, Roth BL, Glennon RA. 9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist. European Journal of Pharmacology. 380: R5-7. PMID 10513561 DOI: 10.1016/S0014-2999(99)00525-7 |
0.623 |
|
| 1999 |
Westkaemper RB, Hyde EG, Choudhary MS, Khan N, Gelbar EI, Glennon RA, Roth BL. Engineering a region of bulk tolerance in the 5-ht(2a) receptor European Journal of Medicinal Chemistry. 34: 441-447. DOI: 10.1016/S0223-5234(99)80094-4 |
0.584 |
|
| 1996 |
Glennon RA, Dukat M, Westkaemper RB, Ismaiel AM, Izzarelli DG, Parker EM. The binding of propranolol at 5-hydroxytryptamine1Dβ T355N mutant receptors may involve formation of two hydrogen bonds to asparagine Molecular Pharmacology. 49: 198-206. PMID 8569707 |
0.423 |
|
| 1996 |
Westkaemper RB. Construction of 3-helix models of the nicotinic receptor ligand binding site Medicinal Chemistry Research. 6: 511-525. |
0.476 |
|
| 1995 |
Choudhary MS, Sachs N, Uluer A, Glennon RA, Westkaemper RB, Roth BL. Differential ergoline and ergopeptine binding to 5-hydroxytryptamine2A receptors: ergolines require an aromatic residue at position 340 for high affinity binding. Molecular Pharmacology. 47: 450-7. PMID 7700242 |
0.313 |
|
| 1994 |
Westkaemper RB, Glennon RA. Molecular modeling of the interaction of LSD and other hallucinogens with 5-HT2 receptors Nida Research Monograph. 146: 263-283. PMID 8742803 |
0.365 |
|
| 1993 |
Glennon RA, Westkaemper RB. 5-HT(1D) receptors: A serotonin receptor population for the 1990s Drug News and Perspectives. 6: 390-405. |
0.352 |
|
| 1991 |
Westkaemper RB, Glennon RA. Approaches to molecular modeling studies and specific application to serotonin ligands and receptors Pharmacology, Biochemistry and Behavior. 40: 1019-1031. PMID 1816556 DOI: 10.1016/0091-3057(91)90122-I |
0.471 |
|
| 1988 |
Grayson NA, Westkaemper RB. Stable analogs of acyl adenylates. Inhibition of acetyl- and acyl-coa synthetase by adenosine 5′-alkylphosphates Life Sciences. 43: 437-444. PMID 2899829 DOI: 10.1016/0024-3205(88)90523-1 |
0.32 |
|
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