☰

Denis C. Shields, PhD - Publications

Affiliations: 
Complex and Adaptive Systems Laboratory University College Dublin, Dublin, County Dublin, Ireland 
Area:
Genetics, Bioinformatics
Website:
http://bioinfo-casl.ucd.ie/shields
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94/268 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Agoni C, Stavropoulos I, Kirwan A, Mysior MM, Holton T, Kranjc T, Simpson JC, Roche HM, Shields DC. Cell-Penetrating Milk-Derived Peptides with a Non-Inflammatory Profile. Molecules (Basel, Switzerland). 28. PMID 37836842 DOI: 10.3390/molecules28196999  0.643
2021 Mészáros B, Sámano-Sánchez H, Alvarado-Valverde J, Čalyševa J, Martínez-Pérez E, Alves R, Shields DC, Kumar M, Rippmann F, Chemes LB, Gibson TJ. Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications. Science Signaling. 14. PMID 33436497 DOI: 10.1126/scisignal.abd0334  0.569
2020 Seoighe C, Bracken AP, Buckley P, Doran P, Green R, Healy S, Kavanagh D, Kenny E, Lawler M, Lowery M, Morris D, Morrissey D, O'Byrne JJ, Shields D, Smith O, et al. The future of genomics in Ireland - focus on genomics for health. Hrb Open Research. 3: 89. PMID 33855271 DOI: 10.12688/hrbopenres.13187.1  0.522
2020 McGauran G, Dorris E, Borza R, Morgan N, Shields DC, Matallanas D, Wilson AG, O'Connell DJ. Resolving the Interactome of the Human Immune Regulator MACIR with Enhanced Membrane Protein Preparation and Affinity Proteomics. Proteomics. e2000062. PMID 32864787 DOI: 10.1002/Pmic.202000062  0.412
2020 O'Brien KT, Mooney C, Lopez C, Pollastri G, Shields DC. Prediction of polyproline II secondary structure propensity in proteins. Royal Society Open Science. 7: 191239. PMID 32218953 DOI: 10.1098/Rsos.191239  0.405
2019 Manguy J, Shields DC. Implications of kappa-casein evolutionary diversity for the self-assembly and aggregation of casein micelles. Royal Society Open Science. 6: 190939. PMID 31824707 DOI: 10.1098/Rsos.190939  0.379
2019 Davey NE, Babu MM, Blackledge M, Bridge A, Capella-Gutierrez S, Dosztanyi Z, Drysdale R, Edwards RJ, Elofsson A, Felli IC, Gibson TJ, Gutmanas A, Hancock JM, Harrow J, Higgins D, ... ... Shields DC, et al. An intrinsically disordered proteins community for ELIXIR. F1000research. 8. PMID 31824649 DOI: 10.12688/F1000Research.20136.1  0.7
2019 Duffy F, Maheshwari N, Buchete NV, Shields D. Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein-Protein Interactions. Methods in Molecular Biology (Clifton, N.J.). 2001: 73-95. PMID 31134568 DOI: 10.1007/978-1-4939-9504-2_5  0.353
2019 O'Brien KT, Golla K, Kranjc T, O'Donovan D, Allen S, Maguire P, Simpson JC, O'Connell D, Moran N, Shields DC. Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome. Plos One. 14: e0210337. PMID 30689642 DOI: 10.1371/Journal.Pone.0210337  0.41
2018 Golla K, Stavropoulos I, Shields DC, Moran N. Peptides derived from cadherin juxtamembrane region inhibit platelet function. Royal Society Open Science. 5: 172347. PMID 30473799 DOI: 10.1098/Rsos.172347  0.356
2018 Krassowski T, Coughlan AY, Shen XX, Zhou X, Kominek J, Opulente DA, Riley R, Grigoriev IV, Maheshwari N, Shields DC, Kurtzman CP, Hittinger CT, Rokas A, Wolfe KH. Evolutionary instability of CUG-Leu in the genetic code of budding yeasts. Nature Communications. 9: 1887. PMID 29760453 DOI: 10.1038/S41467-018-04374-7  0.533
2018 Drummond E, Flynn S, Whelan H, Nongonierma AB, Holton TA, Robinson A, Egan T, Cagney G, Shields DC, Gibney ER, Newsholme P, Gaudel C, Jacquier JC, Noronha N, Fitzgerald RJ, et al. A casein hydrolysate with glycaemic control properties: evidence from cell, animal models and humans. Journal of Agricultural and Food Chemistry. PMID 29638124 DOI: 10.1021/Acs.Jafc.7B05550  0.64
2016 Kranjc T, Dempsey E, Cagney G, Nakamura N, Shields DC, Simpson JC. Functional characterisation of the YIPF protein family in mammalian cells. Histochemistry and Cell Biology. PMID 27999994 DOI: 10.1007/S00418-016-1527-3  0.353
2016 Manguy J, Jehl P, Dillon ET, Davey NE, Shields DC, Holton TA. Peptigram: A Web-Based Application for Peptidomics Data Visualization. Journal of Proteome Research. PMID 27997202 DOI: 10.1021/Acs.Jproteome.6B00751  0.739
2016 Jehl P, Manguy J, Shields DC, Higgins DG, Davey NE. ProViz-a web-based visualization tool to investigate the functional and evolutionary features of protein sequences. Nucleic Acids Research. PMID 27085803 DOI: 10.1093/Nar/Gkw265  0.582
2016 Holton TA, Dillon ET, Robinson A, Wynne K, Cagney G, Shields DC. Optimal computational comparison of mass spectrometric peptide profiles of alternative hydrolysates from the same starting material Lwt. 73: 296-302. DOI: 10.1016/J.Lwt.2016.06.025  0.676
2015 Olorin E, O'Brien KT, Palopoli N, Pérez-Bercoff Å, Shields DC, Edwards RJ. SLiMScape 3.x: a Cytoscape 3 app for discovery of Short Linear Motifs in protein interaction networks. F1000research. 4: 477. PMID 26674271 DOI: 10.12688/F1000Research.6773.1  0.507
2015 Bianchin A, Bell A, Chubb AJ, Doolan N, Leneghan D, Stavropoulos I, Shields DC, Mooney C. Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion. Plos One. 10: e0127383. PMID 26039561 DOI: 10.1371/Journal.Pone.0127383  0.378
2015 Duffy FJ, O'Donovan D, Devocelle M, Moran N, O'Connell DJ, Shields DC. Virtual screening using combinatorial cyclic peptide libraries reveals protein interfaces readily targetable by cyclic peptides. Journal of Chemical Information and Modeling. 55: 600-13. PMID 25668361 DOI: 10.1021/Ci500431Q  0.419
2015 Duffy FJ, Devocelle M, Shields DC. Computational approaches to developing short cyclic peptide modulators of protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 1268: 241-71. PMID 25555728 DOI: 10.1007/978-1-4939-2285-7_11  0.365
2014 Holton TA, Vijayakumar V, Dallas DC, Guerrero A, Borghese RA, Lebrilla CB, German JB, Barile D, Underwood MA, Shields DC, Khaldi N. Following the digestion of milk proteins from mother to baby. Journal of Proteome Research. 13: 5777-83. PMID 25385259 DOI: 10.1021/Pr5006907  0.635
2014 Duffy FJ, Devocelle M, Croucher DR, Shields DC. Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions. Bmc Bioinformatics. 15: 305. PMID 25231912 DOI: 10.1186/1471-2105-15-305  0.42
2014 Nongonierma AB, Mooney C, Shields DC, Fitzgerald RJ. In silico approaches to predict the potential of milk protein-derived peptides as dipeptidyl peptidase IV (DPP-IV) inhibitors Peptides. 57: 43-51. PMID 24793774 DOI: 10.1016/J.Peptides.2014.04.018  0.344
2014 Khaldi N, Vijayakumar V, Dallas DC, Guerrero A, Wickramasinghe S, Smilowitz JT, Medrano JF, Lebrilla CB, Shields DC, German JB. Predicting the important enzymes in human breast milk digestion. Journal of Agricultural and Food Chemistry. 62: 7225-32. PMID 24620897 DOI: 10.1021/Jf405601E  0.345
2014 Ruhanen H, Hurley D, Ghosh A, O'Brien KT, Johnston CR, Shields DC. Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey. Frontiers in Microbiology. 5: 4. PMID 24478765 DOI: 10.3389/Fmicb.2014.00004  0.441
2014 Khaldi N, Holton TA, Shields DC. Amino acid enrichment and compositional changes among mammalian milk proteins and the resulting nutritional consequences. Journal of Dairy Science. 97: 1248-58. PMID 24472131 DOI: 10.3168/Jds.2013-7317  0.679
2013 Holton TA, Pollastri G, Shields DC, Mooney C. CPPpred: prediction of cell penetrating peptides. Bioinformatics (Oxford, England). 29: 3094-6. PMID 24064418 DOI: 10.1093/Bioinformatics/Btt518  0.677
2013 Khan W, Duffy F, Pollastri G, Shields DC, Mooney C. Predicting binding within disordered protein regions to structurally characterised peptide-binding domains. Plos One. 8: e72838. PMID 24019881 DOI: 10.1371/Journal.Pone.0072838  0.425
2013 O'Brien KT, Haslam NJ, Shields DC. SLiMScape: A protein short linear motif analysis plugin for Cytoscape Bmc Bioinformatics. 14. PMID 23855714 DOI: 10.1186/1471-2105-14-224  0.755
2013 Nongonierma AB, Mooney C, Shields DC, FitzGerald RJ. Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides Food Chemistry. 141: 644-653. PMID 23768405 DOI: 10.1016/J.Foodchem.2013.02.115  0.313
2013 Pushker R, Mooney C, Davey NE, Jacqué JM, Shields DC. Marked variability in the extent of protein disorder within and between viral families. Plos One. 8: e60724. PMID 23620725 DOI: 10.1371/Journal.Pone.0060724  0.536
2013 Mooney C, Cessieux A, Shields DC, Pollastri G. SCL-Epred: a generalised de novo eukaryotic protein subcellular localisation predictor. Amino Acids. 45: 291-9. PMID 23568340 DOI: 10.1007/S00726-013-1491-3  0.411
2013 Mooney C, Haslam NJ, Holton TA, Pollastri G, Shields DC. PeptideLocator: prediction of bioactive peptides in protein sequences. Bioinformatics (Oxford, England). 29: 1120-6. PMID 23505299 DOI: 10.1093/Bioinformatics/Btt103  0.786
2012 Vijayakumar V, Guerrero AN, Davey N, Lebrilla CB, Shields DC, Khaldi N. EnzymePredictor: a tool for predicting and visualizing enzymatic cleavages of digested proteins. Journal of Proteome Research. 11: 6056-65. PMID 23098558 DOI: 10.1021/Pr300721F  0.561
2012 Mooney C, Haslam NJ, Pollastri G, Shields DC. Towards the improved discovery and design of functional peptides: common features of diverse classes permit generalized prediction of bioactivity. Plos One. 7: e45012. PMID 23056189 DOI: 10.1371/Journal.Pone.0045012  0.735
2012 Haslam NJ, Shields DC. Peptide-binding domains: Are limp handshakes safest? Science Signaling. 5. PMID 23012652 DOI: 10.1126/Scisignal.2003372  0.739
2012 Davey NE, Cowan JL, Shields DC, Gibson TJ, Coldwell MJ, Edwards RJ. SLiMPrints: conservation-based discovery of functional motif fingerprints in intrinsically disordered protein regions. Nucleic Acids Research. 40: 10628-41. PMID 22977176 DOI: 10.1093/Nar/Gks854  0.745
2012 Stavropoulos I, Khaldi N, Davey NE, O'Brien K, Martin F, Shields DC. Protein disorder and short conserved motifs in disordered regions are enriched near the cytoplasmic side of single-pass transmembrane proteins. Plos One. 7: e44389. PMID 22962613 DOI: 10.1371/Journal.Pone.0044389  0.566
2012 Sudol M, Shields DC, Farooq A. Structures of YAP protein domains reveal promising targets for development of new cancer drugs. Seminars in Cell & Developmental Biology. 23: 827-33. PMID 22609812 DOI: 10.1016/J.Semcdb.2012.05.002  0.328
2012 Haslam NJ, Shields DC. Profile-based short linear protein motif discovery Bmc Bioinformatics. 13. PMID 22607209 DOI: 10.1186/1471-2105-13-104  0.756
2012 Rue-Albrecht K, Shields DC, Khaldi N. Correlation of disorder between S. cerevisiae interacting proteins Molecular Biosystems. 8: 417-425. PMID 22108582 DOI: 10.1039/C1Mb05214D  0.356
2012 Mooney C, Pollastri G, Shields DC, Haslam NJ. Prediction of short linear protein binding regions. Journal of Molecular Biology. 415: 193-204. PMID 22079048 DOI: 10.1016/J.Jmb.2011.10.025  0.778
2012 Casey JP, Magalhaes T, Conroy JM, Regan R, Shah N, Anney R, Shields DC, Abrahams BS, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, et al. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Human Genetics. 131: 565-79. PMID 21996756 DOI: 10.1007/S00439-011-1094-6  0.313
2012 Edwards RJ, Davey NE, O'Brien K, Shields DC. Interactome-wide prediction of short, disordered protein interaction motifs in humans. Molecular Biosystems. 8: 282-95. PMID 21879107 DOI: 10.7490/F1000Research.1089989.1  0.676
2011 Montanari F, Shields DC, Khaldi N. Differences in the number of intrinsically disordered regions between yeast duplicated proteins, and their relationship with functional divergence. Plos One. 6: e24989. PMID 21949823 DOI: 10.1371/Journal.Pone.0024989  0.362
2011 Casey F, Krogan N, Shields DC, Cagney G. Distinct configurations of protein complexes and biochemical pathways revealed by epistatic interaction network motifs. Bmc Systems Biology. 5: 133. PMID 21859460 DOI: 10.1186/1752-0509-5-133  0.374
2011 Khaldi N, Shields DC. Shift in the isoelectric-point of milk proteins as a consequence of adaptive divergence between the milks of mammalian species. Biology Direct. 6: 40. PMID 21801421 DOI: 10.1186/1745-6150-6-40  0.375
2011 Mooney C, Davey N, Martin AJ, Walsh I, Shields DC, Pollastri G. In silico protein motif discovery and structural analysis. Methods in Molecular Biology (Clifton, N.J.). 760: 341-53. PMID 21780007 DOI: 10.1007/978-1-61779-176-5_21  0.596
2011 Davey NE, Haslam NJ, Shields DC, Edwards RJ. SLiMSearch 2.0: biological context for short linear motifs in proteins. Nucleic Acids Research. 39: W56-60. PMID 21622654 DOI: 10.1093/Nar/Gkr402  0.802
2011 Duffy FJ, Verniere M, Devocelle M, Bernard E, Shields DC, Chubb AJ. CycloPs: Generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids Journal of Chemical Information and Modeling. 51: 829-836. PMID 21434641 DOI: 10.1021/Ci100431R  0.333
2011 Alendé N, Nielsen JE, Shields DC, Khaldi N. Evolution of the isoelectric point of mammalian proteins as a consequence of indels and adaptive evolution. Proteins. 79: 1635-48. PMID 21387414 DOI: 10.1002/Prot.22990  0.378
2010 Davey NE, Edwards RJ, Shields DC. Computational identification and analysis of protein short linear motifs. Frontiers in Bioscience (Landmark Edition). 15: 801-25. PMID 20515727 DOI: 10.2741/3647  0.682
2010 Davey NE, Haslam NJ, Shields DC, Edwards RJ. SLiMFinder: a web server to find novel, significantly over-represented, short protein motifs. Nucleic Acids Research. 38: W534-9. PMID 20497999 DOI: 10.1093/Nar/Gkq440  0.794
2010 Davey NE, Edwards RJ, Shields DC. Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated proteins. Bmc Bioinformatics. 11: 14. PMID 20055997 DOI: 10.1186/1471-2105-11-14  0.672
2010 Davey NE, Haslam NJ, Shields DC, Edwards RJ. SLiMSearch: A webserver for finding novel occurrences of short linear motifs in proteins, incorporating sequence context Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 6282: 50-61. DOI: 10.1007/978-3-642-16001-1_5  0.794
2009 Casey FP, Pihan E, Shields DC. Discovery of small molecule inhibitors of protein-protein interactions using combined ligand and target score normalization Journal of Chemical Information and Modeling. 49: 2708-2717. PMID 19994847 DOI: 10.1021/Ci900294X  0.379
2009 Bernard E, Parthasarathi L, Cho MK, Aylward K, Raab M, Daxecker H, O'Dushlaine CT, Shields DC, Devocelle M, Keyes T, Cosgrave L, O'Neill S, Mok KH, Moran N. Ligand switching in cell-permeable peptides: Manipulation of the α-integrin signature motif Acs Chemical Biology. 4: 457-471. PMID 19371094 DOI: 10.1021/Cb8002623  0.343
2009 Davey NE, Shields DC, Edwards RJ. Masking residues using context-specific evolutionary conservation significantly improves short linear motif discovery. Bioinformatics (Oxford, England). 25: 443-50. PMID 19136552 DOI: 10.1093/Bioinformatics/Btn664  0.689
2008 Parthasarathi L, Casey F, Stein A, Aloy P, Shields DC. Approved drug mimics of short peptide ligands from protein interaction motifs Journal of Chemical Information and Modeling. 48: 1943-1948. PMID 18826301 DOI: 10.1021/Ci800174C  0.366
2008 Casey FP, Davey NE, Baran I, Varekova RS, Shields DC. Web server to identify similarity of amino acid motifs to compounds (SAAMCO). Journal of Chemical Information and Modeling. 48: 1524-9. PMID 18570372 DOI: 10.1021/Ci8000474  0.578
2008 O'Dushlaine CT, Shields DC. Marked variation in predicted and observed variability of tandem repeat loci across the human genome Bmc Genomics. 9. PMID 18416815 DOI: 10.1186/1471-2164-9-175  0.31
2008 Edwards RJ, Davey NE, Shields DC. CompariMotif: quick and easy comparisons of sequence motifs. Bioinformatics (Oxford, England). 24: 1307-9. PMID 18375965 DOI: 10.1093/Bioinformatics/Btn105  0.66
2008 Shields DC, Johnston CR, Wallace IM, Edwards RJ. Evolution of specificity and diversity Ancestral Sequence Reconstruction. DOI: 10.1093/acprof:oso/9780199299188.003.0019  0.384
2007 Edwards RJ, Davey NE, Shields DC. SLiMFinder: a probabilistic method for identifying over-represented, convergently evolved, short linear motifs in proteins. Plos One. 2: e967. PMID 17912346 DOI: 10.1371/Journal.Pone.0000967  0.679
2007 Davey NE, Edwards RJ, Shields DC. The SLiMDisc server: short, linear motif discovery in proteins. Nucleic Acids Research. 35: W455-9. PMID 17576682 DOI: 10.1093/Nar/Gkm400  0.683
2007 Baran I, Varekova RS, Parthasarathi L, Suchomel S, Casey F, Shields DC. Identification of potential small molecule peptidomimetics similar to motifs in proteins. Journal of Chemical Information and Modeling. 47: 464-74. PMID 17309247 DOI: 10.1021/Ci600404Q  0.416
2007 Edwards RJ, Moran N, Devocelle M, Kiernan A, Meade G, Signac W, Foy M, Park SD, Dunne E, Kenny D, Shields DC. Bioinformatic discovery of novel bioactive peptides. Nature Chemical Biology. 3: 108-12. PMID 17220901 DOI: 10.1038/Nchembio854  0.535
2007 Johnston CR, O'Dushlaine C, Fitzpatrick DA, Edwards RJ, Shields DC. Evaluation of whether accelerated protein evolution in chordates has occurred before, after, or simultaneously with gene duplication. Molecular Biology and Evolution. 24: 315-23. PMID 17065596 DOI: 10.1093/Molbev/Msl162  0.524
2006 O'Dushlaine CT, Shields DC. Tools for the identification of variable and potentially variable tandem repeats. Bmc Genomics. 7: 290. PMID 17107618 DOI: 10.1186/1471-2164-7-290  0.344
2006 Parthasarathi L, Devocelle M, Søndergaard C, Baran I, O'Dushlaine CT, Davey NE, Edwards RJ, Moran N, Kenny D, Shields DC. Absolute net charge and the biological activity of oligopeptides. Journal of Chemical Information and Modeling. 46: 2183-90. PMID 16995748 DOI: 10.1021/Ci0600760  0.642
2006 Moran N, Kiernan A, Dunne E, Edwards RJ, Shields DC, Kenny D. Monitoring modulators of platelet aggregation in a microtiter plate assay. Analytical Biochemistry. 357: 77-84. PMID 16920064 DOI: 10.1016/J.Ab.2006.06.037  0.43
2006 Davey NE, Shields DC, Edwards RJ. SLiMDisc: short, linear motif discovery, correcting for common evolutionary descent. Nucleic Acids Research. 34: 3546-54. PMID 16855291 DOI: 10.1093/Nar/Gkl486  0.686
2005 Cagney G, Park S, Chung C, Tong B, O'Dushlaine C, Shields DC, Emili A. Human tissue profiling with multidimensional protein identification technology. Journal of Proteome Research. 4: 1757-67. PMID 16212430 DOI: 10.1021/Pr0500354  0.328
2005 Edwards RJ, Shields DC. BADASP: predicting functional specificity in protein families using ancestral sequences. Bioinformatics (Oxford, England). 21: 4190-1. PMID 16159912 DOI: 10.1093/Bioinformatics/Bti678  0.571
2005 O'Dushlaine CT, Edwards RJ, Park SD, Shields DC. Tandem repeat copy-number variation in protein-coding regions of human genes. Genome Biology. 6: R69. PMID 16086851 DOI: 10.1186/Gb-2005-6-8-R69  0.548
2005 Johnston CR, Shields DC. A sequence sub-sampling algorithm increases the power to detect distant homologues. Nucleic Acids Research. 33: 3772-8. PMID 16006623 DOI: 10.1093/Nar/Gki687  0.33
2004 Edwards RJ, Shields DC. GASP: Gapped Ancestral Sequence Prediction for proteins. Bmc Bioinformatics. 5: 123. PMID 15350199 DOI: 10.1186/1471-2105-5-123  0.528
2003 Shields DC. Molecular evolution of CXC chemokines and receptors. Trends in Immunology. 24: 355; author reply 35. PMID 12860523 DOI: 10.1016/S1471-4906(03)00138-8  0.34
2003 Seoighe C, Johnston CR, Shields DC. Significantly different patterns of amino acid replacement after gene duplication as compared to after speciation. Molecular Biology and Evolution. 20: 484-90. PMID 12654935 DOI: 10.1093/Molbev/Msg059  0.627
2003 Hokamp K, Shields DC, Wolfe KH, Caffrey DR. Wrapping up BLAST and other applications for use on Unix clusters. Bioinformatics (Oxford, England). 19: 441-2. PMID 12584141 DOI: 10.1093/Bioinformatics/Btg007  0.503
2002 Shields DC, O'Halloran AM. Integrating genotypic data with transcriptomic and proteomic data. Comparative and Functional Genomics. 3: 22-7. PMID 18628875 DOI: 10.1002/Cfg.135  0.329
2002 Cotter PJ, Caffrey DR, Shields DC. Improved database searches for orthologous sequences by conditioning on outgroup sequences. Bioinformatics (Oxford, England). 18: 83-91. PMID 11836215 DOI: 10.1093/Bioinformatics/18.1.83  0.349
2000 Caffrey DR, O'Neill LA, Shields DC. A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways. Protein Science : a Publication of the Protein Society. 9: 655-70. PMID 10794408 DOI: 10.1110/Ps.9.4.655  0.371
2000 Shields DC. Gene conversion among chemokine receptors Gene. 246: 239-245. PMID 10767545 DOI: 10.1016/S0378-1119(00)00072-X  0.304
1997 Wolfe KH, Shields DC. Molecular evidence for an ancient duplication of the entire yeast genome. Nature. 387: 708-13. PMID 9192896 DOI: 10.1038/42711  0.566
1997 Shields DC, Wolfe KH. Accelerated evolution of sites undergoing mRNA editing in plant mitochondria and chloroplasts. Molecular Biology and Evolution. 14: 344-9. PMID 9066800 DOI: 10.1093/Oxfordjournals.Molbev.A025768  0.534
1996 Uhlar CM, Black IL, Shields DC, Brack CM, Schreiber G, Whitehead AS. Wallaby serum amyloid A protein: cDNA cloning, sequence and evolutionary analysis Scandinavian Journal of Immunology. 43: 271-276. PMID 8602460 DOI: 10.1046/J.1365-3083.1996.D01-34.X  0.361
1992 Shields DC, Higgins DG, Sharp PM. GCWIND: a microcomputer program for identifying open reading frames according to codon positional G+C content. Computer Applications in the Biosciences : Cabios. 8: 521-3. PMID 1422886 DOI: 10.1093/Bioinformatics/8.5.521  0.631
1990 Sharp PM, Higgins DG, Shields DC, Devine KM, Hoch JA. Bacillus Subtilis Gene Sequences Genetics and Biotechnology of Bacilli. 89-98. DOI: 10.1016/B978-0-12-274162-3.50013-X  0.526
1989 Sharp PM, Shields DC, Wolfe KH, Li WH. Chromosomal location and evolutionary rate variation in enterobacterial genes. Science (New York, N.Y.). 246: 808-10. PMID 2683084 DOI: 10.1126/Science.2683084  0.636
1989 Shields DC, Sharp PM. Evidence that mutation patterns vary among Drosophila transposable elements. Journal of Molecular Biology. 207: 843-6. PMID 2547975 DOI: 10.1016/0022-2836(89)90252-0  0.534
1988 Shields DC, Sharp PM, Higgins DG, Wright F. "Silent" sites in Drosophila genes are not neutral: evidence of selection among synonymous codons. Molecular Biology and Evolution. 5: 704-16. PMID 3146682 DOI: 10.1093/Oxfordjournals.Molbev.A040525  0.606
1988 Sharp PM, Cowe E, Higgins DG, Shields DC, Wolfe KH, Wright F. Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity. Nucleic Acids Research. 16: 8207-11. PMID 3138659 DOI: 10.1093/Nar/16.17.8207  0.702
1987 Shields DC, Sharp PM. Synonymous codon usage in Bacillus subtilis reflects both translational selection and mutational biases. Nucleic Acids Research. 15: 8023-40. PMID 3118331 DOI: 10.1093/Nar/15.19.8023  0.521
Low-probability matches (unlikely to be authored by this person)
2009 O'Halloran AM, Patterson CC, Horan P, Maree A, Curtin R, Stanton A, McKeown PP, Shields DC. Genetic polymorphisms in platelet-related proteins and coronary artery disease: Investigation of candidate genes, including N-acetylgalactosaminyltransferase 4 (GALNT4) and sulphotransferase 1A1/2 (SULT1A1/2) Journal of Thrombosis and Thrombolysis. 27: 175-184. PMID 18259693 DOI: 10.1007/S11239-008-0196-Z  0.297
2008 Casey FP, Cagney G, Krogan NJ, Shields DC. Optimal stepwise experimental design for pairwise functional interaction studies. Bioinformatics (Oxford, England). 24: 2733-9. PMID 18805797 DOI: 10.1093/Bioinformatics/Btn472  0.294
1999 Caffrey DR, O'Neill LAJ, Shields DC. The evolution of the map kinase pathways: Coduplication of interacting proteins leads to new signaling cascades Journal of Molecular Evolution. 49: 567-582. PMID 10552038 DOI: 10.1007/Pl00006578  0.294
2014 Phelan M, Khaldi N, Shields DC, Kerins DM. Angiotensin converting enzyme and nitric oxide inhibitory activities ofnovel milk derived peptides International Dairy Journal. 35: 38-42. DOI: 10.1016/J.Idairyj.2013.10.008  0.293
2004 McRedmond JP, Park SD, Reilly DF, Coppinger JA, Maguire PB, Shields DC, Fitzgerald DJ. Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes. Molecular & Cellular Proteomics : McP. 3: 133-44. PMID 14645502 DOI: 10.1074/Mcp.M300063-Mcp200  0.293
2010 Pushker R, Jacqué JM, Shields DC. Meta-analysis to test the association of HIV-1 nef amino acid differences and deletions with disease progression Journal of Virology. 84: 3644-3653. PMID 20071583 DOI: 10.1128/Jvi.01959-09  0.289
2012 Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, ... ... Shields DC, et al. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics. 90: 410-25. PMID 22325160 DOI: 10.1016/J.Ajhg.2011.12.022  0.284
2011 Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, et al. Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics. 89: 688-700. PMID 22100073 DOI: 10.1016/J.Ajhg.2011.10.013  0.283
2004 Evans A, Salomaa V, Kulathinal S, Asplund K, Cambien F, Ferrario M, Perola M, Peltonen L, Shields D, Tunstall-Pedoe H, Kuulasmaa K. MORGAM (an international pooling of cardiovascular cohorts) International Journal of Epidemiology. 34: 21-27. PMID 15561751 DOI: 10.1093/Ije/Dyh327  0.283
2015 Fitzpatrick DJ, Ryan CJ, Shah N, Greene D, Molony C, Shields DC. Genome-wide epistatic expression quantitative trait loci discovery in four human tissues reveals the importance of local chromosomal interactions governing gene expression. Bmc Genomics. 16: 109. PMID 25765234 DOI: 10.1186/S12864-015-1300-3  0.281
2010 Maree AO, Vangjeli C, Jneid H, Ryan J, Cox D, Cannon CP, Shields DC, Fitzgerald DJ. G-protein β3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial Journal of Thrombosis and Haemostasis. 8: 934-941. PMID 20096003 DOI: 10.1111/J.1538-7836.2010.03775.X  0.28
2005 Kelly H, Ennis S, Yoneda A, Bermingham C, Shields DC, Molony C, Green AJ, Puri P, Barton DE. Uroplakin III is not a major candidate gene for primary vesicoureteral reflux. European Journal of Human Genetics : Ejhg. 13: 500-2. PMID 15523493 DOI: 10.1038/Sj.Ejhg.5201322  0.279
1996 Shields DC, Butler A, Mosurski KR, Walsh MT, Whitehead AS. Mapping genes within a YAC by computer-assisted interpretation of partial restriction digestions Nucleic Acids Research. 24: 4495-4500. PMID 8948640 DOI: 10.1093/Nar/24.22.4495  0.279
2009 Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, ... ... Shields DC, et al. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. American Journal of Human Genetics. 85: 628-42. PMID 19913121 DOI: 10.1016/J.Ajhg.2009.10.014  0.276
2012 Norris R, Casey F, FitzGerald RJ, Shields D, Mooney C. Predictive modelling of angiotensin converting enzyme inhibitory dipeptides Food Chemistry. 133: 1349-1354. DOI: 10.1016/J.Foodchem.2012.02.023  0.276
2006 O'Halloran AM, Stanton A, O'Brien E, Shields DC. The impact on coronary artery disease of common polymorphisms known to modulate responses to pathogens. Annals of Human Genetics. 70: 934-45. PMID 17044867 DOI: 10.1111/J.1469-1809.2006.00281.X  0.273
1995 Cook JT, Shields DC, Page RC, Levy JC, Hattersley AT, Shaw JA, Neil HA, Wainscoat JS, Turner RC. Segregation analysis of NIDDM in Caucasian families. Diabetologia. 37: 1231-40. PMID 7895953 DOI: 10.1007/Bf00399797  0.272
2017 Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, ... ... Shields DC, et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension (Dallas, Tex. : 1979). PMID 28739976 DOI: 10.1161/Hypertensionaha.117.09438  0.272
2016 Kanoni S, Masca NG, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W, Yaghootkar H, Müller-Nurasyid M, Couto Alves A, Strawbridge RJ, Lataniotis L, Hashim NA, Besse C, ... ... Shields D, et al. Analysis with the exome array identifies multiple new independent variants in lipid loci. Human Molecular Genetics. PMID 27466198 DOI: 10.1093/Hmg/Ddw227  0.271
2005 Molony CM, Fitzgerald AP, Shields DC. Overdispersion of allele frequency differences between populations: implications for meta-analyses of genotypic disease associations. European Journal of Human Genetics : Ejhg. 13: 79-85. PMID 15470368 DOI: 10.1038/Sj.Ejhg.5201275  0.271
2009 Miller J, Agarwal A, Devi LA, Fontanini K, Hamilton JA, Pin JP, Shields DC, Spek CA, Sakmar TP, Kuliopulos A, Hunt SW. Insider access: pepducin symposium explores a new approach to GPCR modulation. Annals of the New York Academy of Sciences. 1180: E1-12. PMID 19925639 DOI: 10.1111/J.1749-6632.2009.05326.X  0.27
2011 Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, ... ... Shields DC, et al. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics. 88: 6-18. PMID 21194676 DOI: 10.1016/J.Ajhg.2010.11.007  0.269
2004 Byrne CE, Fitzgerald A, Cannon CP, Fitzgerald DJ, Shields DC. Elevated white cell count in acute coronary syndromes: relationship to variants in inflammatory and thrombotic genes. Bmc Medical Genetics. 5: 13. PMID 15171792 DOI: 10.1186/1471-2350-5-13  0.266
2016 Crowe A, Sánchez-Sanz G, Tywoniuk B, Shields DC, Buchete N. Coarse Master Equation-Based Analysis of N-Methylation and Temperature Effects on the Dynamics of Cyclic Peptides Biophysical Journal. 110: 379a. DOI: 10.1016/J.Bpj.2015.11.2046  0.266
1996 De Roux N, Shields DC, Misrahi M, Ratanachaiyavong S, McGregor AM, Milgrom E. Analysis of the thyrotropin receptor as a candidate gene in familial Graves' disease Journal of Clinical Endocrinology and Metabolism. 81: 3483-3486. PMID 8855789 DOI: 10.1210/Jcem.81.10.8855789  0.265
2000 Muckian C, Hillmann A, Kenny D, Shields DC. A novel variant of the platelet glycoprotein Ibα macroglycopeptide region lacks any copies of the 'Perfect' 13 amino acid repeat Thrombosis and Haemostasis. 83: 513-514. PMID 10744166 DOI: 10.1055/S-0037-1613849  0.265
2000 Hillmann A, Shields DC, Fitzgerald DJ, Kenny D. Polymorphisms in glycoprotein (GP) lb alpha are not associated with adverse outcomes in primigravidae. Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology. 20: 250-5. PMID 15512545 DOI: 10.1080/01443610050009548  0.263
2002 Muckian C, Fitzgerald A, O'Neill A, O'Byrne A, Fitzgerald DJ, Shields DC. Genetic variability in the extracellular matrix as a determinant of cardiovascular risk: association of type III collagen COL3A1 polymorphisms with coronary artery disease. Blood. 100: 1220-3. PMID 12149201 DOI: 10.1182/Blood-2002-01-0283  0.263
1999 Hawi Z, Mynett-Johnson L, Gill M, Murphy V, Straubl RE, Kendler KS, Walsh D, Machen F, Connell H, McKeon P, Shields D. Pseudoautosomal gene Psychiatric Genetics. 9: 129-134. DOI: 10.1097/00041444-199909000-00003  0.262
2005 Hawi Z, Segurado R, Conroy J, Sheehan K, Lowe N, Kirley A, Shields D, Fitzgerald M, Gallagher L, Gill M. Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder American Journal of Human Genetics. 77: 958-965. PMID 16380908 DOI: 10.1086/498174  0.26
1994 McCarthy MI, Hitman GA, Shields DC, Morton NE, Snehalatha C, Mohan V, Ramachandran A, Viswanathan M. Family studies of non-insulin-dependent diabetes mellitus in South Indians. Diabetologia. 37: 1221-30. PMID 7895952 DOI: 10.1007/Bf00399796  0.26
2023 Bera I, O'Sullivan M, Flynn D, Shields DC. Relationship between Protein Digestibility and the Proteolysis of Legume Proteins during Seed Germination. Molecules (Basel, Switzerland). 28. PMID 37049968 DOI: 10.3390/molecules28073204  0.256
2008 Grisoni ML, Proust C, Alanne M, DeSuremain M, Salomaa V, Kuulasmaa K, Cambien F, Nicaud V, Stegmayr B, Virtamo J, Shields D, Kee F, Tiret L, Evans A, Tregouet DA. Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: The MORGAM Project European Journal of Human Genetics. 16: 1512-1520. PMID 18628791 DOI: 10.1038/Ejhg.2008.127  0.256
2012 Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen YD, Gaunt TR, ... ... Shields DC, et al. Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American Journal of Human Genetics. 91: 823-38. PMID 23063622 DOI: 10.1016/J.Ajhg.2012.08.032  0.256
1997 Mynett-Johnson LA, Murphy VE, Manley P, Shields DC, McKeon P. Lack of evidence for a major locus for bipolar disorder in the pericentromeric region of chromosome 18 in Irish pedigrees Biological Psychiatry. 42: 486-494. PMID 9285084 DOI: 10.1016/S0006-3223(96)00427-1  0.255
2013 O'Brien RP, Phelan PJ, Conroy J, O'Kelly P, Green A, Keogan M, O'Neill D, Jennings S, Traynor C, Casey J, McCormack M, Conroy R, Chubb A, Ennis S, Shields DC, et al. A genome-wide association study of recipient genotype and medium-term kidney allograft function. Clinical Transplantation. 27: 379-87. PMID 23432519 DOI: 10.1111/Ctr.12093  0.254
2000 Malcuit I, de Jong W, Baulcombe DC, Shields DC, Kavanagh TA. Acquisition of multiple virulence/avirulence determinants by potato virus X (PVX) has occurred through convergent evolution rather than through recombination. Virus Genes. 20: 165-72. PMID 10872879 DOI: 10.1023/A:1008178800366  0.254
2003 Martin K, Meade G, Moran N, Shields DC, Kenny D. A palmitylated peptide derived from the glycoprotein Ib beta cytoplasmic tail inhibits platelet activation. Journal of Thrombosis and Haemostasis : Jth. 1: 2643-52. PMID 14675101 DOI: 10.1046/J.1538-7836.2003.00478.X  0.253
2017 Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJ, Völker U, Großmann V, Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, ... ... Shields DC, et al. Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. The Journal of Clinical Investigation. PMID 28394258 DOI: 10.1172/Jci84840  0.253
2010 Surendran P, Stanton A, Shields DC. Genome wide association study of non synonymous single nucleotide polymorphisms with seven common diseases F1000research. 1. DOI: 10.7490/F1000Research.376.1  0.252
1997 Harmon DL, McMaster D, McCluskey DR, Shields DC, Whitehead AS. A common genetic variant affecting folate metabolism is not over-represented in chronic fatigue syndrome Annals of Clinical Biochemistry. 34: 427-429. PMID 9247678 DOI: 10.1177/000456329703400416  0.252
1998 Mynett-Johnson L, Murphy V, McCormack J, Shields DC, Claffey E, Manley P, McKeon P. Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3) Biological Psychiatry. 44: 47-51. PMID 9646882 DOI: 10.1016/S0006-3223(97)00343-0  0.252
2005 Dolan C, O'Halloran A, Bradley DG, Croke DT, Evans A, O'Brien JK, Dicker P, Shields DC. Genetic stratification of pathogen-response-related and other variants within a homogeneous Caucasian Irish population. European Journal of Human Genetics : Ejhg. 13: 798-806. PMID 15785776 DOI: 10.1038/Sj.Ejhg.5201382  0.251
1995 Whitehead AS, Gallagher P, Mills JL, Kirke PN, Burke H, Molloy AM, Weir DG, Shields DC, Scott JM. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects Qjm: An International Journal of Medicine. 88: 763-766. DOI: 10.1093/Oxfordjournals.Qjmed.A069003  0.251
2010 Surendran P, Stanton A, Shields D. Genome wide association study of nonsynonymous Single Nucleotide Polymorphisms for seven common diseases Bmc Bioinformatics. 11. DOI: 10.1186/1471-2105-11-S10-O6  0.25
1990 Shields DC. Switches in species-specific codon preferences: the influence of mutation biases. Journal of Molecular Evolution. 31: 71-80. PMID 2120452 DOI: 10.1007/Bf02109476  0.25
2005 Dolan C, Shields DC, Stanton A, O'Brien E, Lambert DM, O'Brien JK, Treacy EP. Polymorphisms of the Flavin containing monooxygenase 3 (FMO3) gene do not predispose to essential hypertension in Caucasians. Bmc Medical Genetics. 6: 41. PMID 16324215 DOI: 10.1186/1471-2350-6-41  0.249
1995 Shields DC, McDevitt D, Foster TJ. Evidence against concerted evolution in a tandem array in the clumping factor gene of Staphylococcus aureus Molecular Biology and Evolution. 12: 963-965. PMID 7476144 DOI: 10.1093/Oxfordjournals.Molbev.A040275  0.248
1999 Harmon DL, Shields DC, Woodside JV, McMaster D, Yarnell JWG, Young IS, Peng K, Shane B, Evans AE, Whitehead AS. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations Genetic Epidemiology. 17: 298-309. PMID 10520212 DOI: 10.1002/(Sici)1098-2272(199911)17:4<298::Aid-Gepi5>3.0.Co;2-V  0.245
2015 Bianchin A, Bell A, Chubb AJ, Doolan N, Leneghan D, Stavropoulos I, Shields DC, Mooney C. Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion Plos One. 10. DOI: 10.1371/journal.pone.0127383  0.245
2017 Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, ... ... Shields DC, et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics. PMID 28135244 DOI: 10.1038/Ng.3768  0.245
1999 Shields DC, Kirke PN, Mills JL, Ramsbottom D, Molloy AM, Burke H, Weir DG, Scott JM, Whitehead AS. The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother. American Journal of Human Genetics. 64: 1045-55. PMID 10090889 DOI: 10.1086/302310  0.245
2002 Shields DC, Fitzgerald AP, O'Neill PA, Muckian C, Kenny D, Moran B, Cannon CP, Byrne CE, Fitzgerald DJ. The contribution of genetic factors to thrombotic and bleeding outcomes in coronary patients randomised to IIb/IIIa antagonists. The Pharmacogenomics Journal. 2: 182-90. PMID 12082590 DOI: 10.1038/Sj.Tpj.6500100  0.242
1992 Morton NE, Shields DC, Collins A. Genetic epidemiology of complex phenotypes. Annals of Human Genetics. 55: 301-14. PMID 1819230 DOI: 10.1111/J.1469-1809.1991.Tb00857.X  0.242
2011 Vangjeli C, Dicker P, Tregouet DA, Shields DC, Evans A, Stanton AV. A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: The MORGAM project Jraas - Journal of the Renin-Angiotensin-Aldosterone System. 12: 504-509. PMID 21490025 DOI: 10.1177/1470320311405557  0.241
2006 Hillmann AG, Harmon S, Park SD, O'brien J, Shields DC, Kenny D. Comparative RNA expression analyses from small-scale, single-donor platelet samples. Journal of Thrombosis and Haemostasis : Jth. 4: 349-56. PMID 16420564 DOI: 10.1111/J.1538-7836.2006.01684.X  0.241
2007 Iohom G, Ni Chonghaile M, O'Brien JK, Cunningham AJ, Fitzgerald DF, Shields DC. An investigation of potential genetic determinants of propofol requirements and recovery from anaesthesia European Journal of Anaesthesiology. 24: 912-919. PMID 17555608 DOI: 10.1017/S0265021507000476  0.241
2013 Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, Cheng YC, Chen WM, Malik R, McCarthy NS, Holliday EG, Speed D, Hasan N, Pucek M, Rinne PE, ... ... Shields DC, et al. Genome-wide analysis of blood pressure variability and ischemic stroke. Stroke; a Journal of Cerebral Circulation. 44: 2703-9. PMID 23929743 DOI: 10.1161/Strokeaha.113.002186  0.241
2012 Deshmukh HA, Colhoun HM, Johnson T, McKeigue PM, Betteridge DJ, Durrington PN, Fuller JH, Livingstone S, Charlton-Menys V, Neil A, Poulter N, Sever P, Shields DC, Stanton AV, Chatterjee A, et al. Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). Journal of Lipid Research. 53: 1000-11. PMID 22368281 DOI: 10.1194/Jlr.P021113  0.24
1997 Harmon DL, McMaster D, Shields DC, Whitehead AS, Rea IM. MTHFR thermolabile genotype frequencies and longevity in Northern Ireland Atherosclerosis. 131: 137-138. PMID 9180255 DOI: 10.1016/S0021-9150(97)06096-6  0.24
2005 Maree AO, Curtin RJ, Chubb A, Dolan C, Cox D, O'Brien J, Crean P, Shields DC, Fitzgerald DJ. Cyclooxygenase-1 haplotype modulates platelet response to aspirin. Journal of Thrombosis and Haemostasis : Jth. 3: 2340-5. PMID 16150050 DOI: 10.1111/J.1538-7836.2005.01555.X  0.24
2015 Lombardi F, Golla K, Fitzpatrick DJ, Casey FP, Moran N, Shields DC. Discovering anti-platelet drug combinations with an integrated model of activator-inhibitor relationships, activator-activator synergies and inhibitor-inhibitor synergies. Plos Computational Biology. 11: e1004119. PMID 25875950 DOI: 10.1371/Journal.Pcbi.1004119  0.239
2007 Moore N, Dicker P, O'Brien JK, Stojanovic M, Conroy RM, Treumann A, O'Brien ET, Fitzgerald D, Shields D, Stanton AV. Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition Hypertension. 50: 340-347. PMID 17562974 DOI: 10.1161/Hypertensionaha.106.085563  0.239
2000 Shields DC, Ramsbottom D, Donoghue C, Pinjon E, Kirke PN, Molloy AM, Edwards YH, Mills JL, Mynett-Johnson L, Weir DG, Scott JM, Whitehead AS. Association between historically high frequencies of neural tube defects and the human T homologue of mouse T (Brachyury). American Journal of Medical Genetics. 92: 206-11. PMID 10817656 DOI: 10.1002/(Sici)1096-8628(20000529)92:3<206::Aid-Ajmg9>3.0.Co;2-W  0.239
2012 Saxena R, Elbers C, Guo Y, Peter I, Gaunt T, Mega J, Lanktree M, Tare A, Castillo B, Li Y, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight B, ... ... Shields D, et al. Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci The American Journal of Human Genetics. 90: 753. DOI: 10.1016/J.Ajhg.2012.03.001  0.238
2004 Collins K, Doherty G, Sweeney M, Byrne S, Aftab A, Kay E, Murray F, Shields D. Polymorphism of the MTHFR Gene is Associated with Altered Gene Expression in Colorectal Cancer Endoscopy. 36. DOI: 10.1055/S-2004-824986  0.238
2012 Lanktree M, Guo Y, Murtaza M, Glessner J, Bailey S, Onland-Moret N, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson C, Klopp N, Baumert J, Padmanabhan S, ... ... Shields D, et al. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height The American Journal of Human Genetics. 90: 1116-1117. DOI: 10.1016/J.Ajhg.2012.05.017  0.238
2002 Kenny D, Muckian C, Fitzgerald DJ, Cannon CP, Shields DC. Platelet glycoprotein Ib alpha receptor polymorphisms and recurrent ischaemic events in acute coronary syndrome patients. Journal of Thrombosis and Thrombolysis. 13: 13-9. PMID 11994555 DOI: 10.1023/A:1015307823578  0.236
1994 Sham PC, Morton NE, Muir WJ, Walker M, Collins A, Shields DC, St Clair DM, Blackwood DH. Segregation analysis of complex phenotypes Psychiatric Genetics. 4: 29-38. DOI: 10.1097/00041444-199421000-00005  0.235
1995 Houlston RS, Collins A, Kee F, Collins BJ, Shields DC, Morton NE. Segregation analysis of colorectal cancer in Northern Ireland Human Heredity. 45: 41-48. PMID 7896299 DOI: 10.1159/000154253  0.235
2013 den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, Westra HJ, Johnson T, Isaacs A, Yang J, Lundby A, ... ... Shields DC, et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics. 45: 621-31. PMID 23583979 DOI: 10.1038/Ng.2610  0.235
1992 Morton NE, Collins A, Lawrence S, Shields DC. Algorithms for a location database. Annals of Human Genetics. 56: 223-32. PMID 1449237 DOI: 10.1111/J.1469-1809.1992.Tb01147.X  0.235
2001 Murphy VE, Mynett-Johnson LA, Claffey E, Shields DC, McKeon P. No association between 5HT-2A and bipolar disorder irrespective of genomic imprinting. American Journal of Medical Genetics. 105: 422-5. PMID 11449393 DOI: 10.1002/Ajmg.1435  0.234
2006 O'Halloran AM, Curtin R, O'Connor F, Dooley M, Fitzgerald A, O'Brien JK, Fitzgerald DJ, Shields DC. The impact of genetic variation in the region of the GPIIIa gene, on Pl expression bias and GPIIb/IIIa receptor density in platelets. British Journal of Haematology. 132: 494-502. PMID 16412022 DOI: 10.1111/J.1365-2141.2005.05897.X  0.234
2012 Lombardi F, De Chaumont C, Shields DC, Moran N. Platelet signalling networks: Pathway perturbation demonstrates differential sensitivity of ADP secretion and fibrinogen binding Platelets. 23: 17-25. PMID 22129436 DOI: 10.3109/09537104.2011.594190  0.233
2007 Lavin PJ, Laing ME, O'Kelly P, Moloney FJ, Gopinathan D, Aradi AA, Shields DC, Murphy GM, Conlon PJ. Improved renal allograft survival with vitamin D receptor polymorphism Renal Failure. 29: 785-789. PMID 17994444 DOI: 10.1080/08860220701540417  0.233
1993 Robinson D, Lamont M, Curtis G, Shields DC, Phelps P. A family with X-linked deafness showing linkage to the proximal Xq region of the X chromosome. Human Genetics. 90: 316-8. PMID 1362559 DOI: 10.1007/Bf00220090  0.232
1996 Shields DC, Harmon DL, Nunez F, Whitehead AS. The evolution of haematopoietic cytokine/receptor complexes. Cytokine. 7: 679-88. PMID 8580377 DOI: 10.1006/Cyto.1995.0080  0.232
2018 Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, ... ... Shields DC, et al. Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. PMID 30429575 DOI: 10.1038/S41588-018-0297-3  0.23
2001 O'Connor FF, Shields DC, Fitzgerald A, Cannon CP, Braunwald E, Fitzgerald DJ. Genetic variation in glycoprotein IIb/IIIa (GPIIb/IIIa) as a determinant of the responses to an oral GPIIb/IIIa antagonist in patients with unstable coronary syndromes. Blood. 98: 3256-60. PMID 11719362 DOI: 10.1182/Blood.V98.12.3256  0.23
2017 Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O' Reilly C, O' Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, et al. Title: Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis. Qjm : Monthly Journal of the Association of Physicians. PMID 29237089 DOI: 10.1093/Qjmed/Hcx243  0.229
1996 Gallagher PM, Meleady R, Shields DC, Tan KS, McMaster D, Rozen R, Evans A, Graham IM, Whitehead AS. Homocysteine and risk of premature coronary heart disease: Evidence for a common gene mutation Circulation. 94: 2154-2158. PMID 8901666 DOI: 10.1161/01.Cir.94.9.2154  0.228
1994 Shields DC, Marlow AJ, Houlston RS, Eccles DM, Morton NE. Prediction of genetic risks from segregation analyses of morbid risks. Human Heredity. 44: 52-5. PMID 8163292 DOI: 10.1159/000154189  0.226
2016 Bajrangee A, Ryan N, Vangjeli C, Brennan M, Cox D, Shields DC, Fitzgerald D, Maree A. Impact of genetic variation in the 5-HT transporter and receptor on platelet function in patients with stable CAD taking aspirin. Thrombosis Research. 146: 51-55. PMID 27597145 DOI: 10.1016/J.Thromres.2016.08.019  0.226
2017 McCarthy NS, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S, Hughes AD, Munroe PB, Howard P, Johnson T, Caulfield M, Shields DC, O'Brien E, et al. Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Atherosclerosis. 269: 42-49. PMID 29258006 DOI: 10.1016/J.Atherosclerosis.2017.12.013  0.224
1993 Phillips DI, Shields DC, Dugoujon JM, Prentice L, McGuffin P, Ree Smith B. Complex segregation analysis of thyroid autoantibodies: are they inherited as an autosomal dominant trait? Human Heredity. 43: 141-6. PMID 8330876 DOI: 10.1159/000154169  0.223
2018 Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, ... ... Shields DC, et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics. PMID 30224653 DOI: 10.1038/S41588-018-0205-X  0.219
2014 Stavropoulos I, Golla K, Moran N, Martin F, Shields DC. Cadherin juxtamembrane region derived peptides inhibit TGFβ1 induced gene expression. Bioarchitecture. 4: 103-10. PMID 25108297 DOI: 10.4161/bioa.32143  0.218
2007 Laing ME, Dicker P, Moloney FJ, Ho WL, Murphy GM, Conlon P, Whitehead AS, Shields DC. Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients. Transplantation. 84: 113-6. PMID 17627246 DOI: 10.1097/01.Tp.0000266069.41882.28  0.217
2001 Shields D. Handbook of Statistical Genetics Briefings in Bioinformatics. 2: 305-307. DOI: 10.1093/Bib/2.3.305  0.217
2001 Cahill M, Karabatzaki M, Donoghue C, Meleady R, Mynett-Johnson LA, Mooney D, Graham IM, Whitehead AS, Shields DC. Thermolabile MTHFR genotype and retinal vascular occlusive disease. The British Journal of Ophthalmology. 85: 88-90. PMID 11133719 DOI: 10.1136/Bjo.85.1.88  0.215
1999 Harmon DL, Doyle RM, Meleady R, Doyle M, Shields DC, Barry R, Coakley D, Graham IM, Whitehead AS. Genetic analysis of the thermolabile variant of 5,10- methylenetetrahydrofolate reductase as a risk factor for ischemic stroke Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 208-211. PMID 9974399 DOI: 10.1161/01.Atv.19.2.208  0.215
2006 Moloney FJ, Dicker P, Conlon PJ, Shields DC, Murphy GM. The frequency and significance of thiopurine S-methyltransferase gene polymorphisms in azathioprine-treated renal transplant recipients. The British Journal of Dermatology. 154: 1199-200. PMID 16704656 DOI: 10.1111/J.1365-2133.2006.07239.X  0.214
2008 Ryan AW, O'Brien E, Shields D, McManus R. Lack of association between NFKBIL1/LTA polymorphisms and hypertension, myocardial infarct, unstable angina and stable angina in a large Irish population sample Atherosclerosis. 197: 465-466. PMID 17485095 DOI: 10.1016/J.Atherosclerosis.2007.03.032  0.214
2018 Murphy K, Murphy BT, Boyce S, Flynn L, Gilgunn S, O'Rourke CJ, Rooney C, Stöckmann H, Walsh AL, Finn S, O'Kennedy RJ, O'Leary J, Pennington SR, Perry AS, Rudd PM, ... ... Shields DC, et al. Integrating biomarkers across omic platforms: an approach to improve stratification of patients with indolent and aggressive prostate cancer. Molecular Oncology. PMID 29927052 DOI: 10.1002/1878-0261.12348  0.211
1994 Attwood J, Chiano M, Collins A, Donis-Keller H, Dracopoli N, Fountain J, Falk C, Goudie D, Gusella J, Haines J, Armour JAL, Jeffreys AJ, Kwiatkowski D, Lathrop M, Matise T, ... ... Shields D, et al. CEPH Consortium Map of Chromosome 9 Genomics. 19: 203-214. PMID 8188250 DOI: 10.1006/Geno.1994.1049  0.207
2000 Cahill M, Karabatzaki M, Meleady R, Refsum H, Ueland P, Shields D, Mooney D, Graham I. Raised plasma homocysteine as a risk factor for retinal vascular occlusive disease. The British Journal of Ophthalmology. 84: 154-7. PMID 10655190 DOI: 10.1136/Bjo.84.2.154  0.205
2016 Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, ... ... Shields DC, et al. Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Journal of Medical Genetics. PMID 27587472 DOI: 10.1136/Jmedgenet-2016-103966  0.205
1995 Shields DC, Collins A, Marlow A. Coding of pointers in the segregation analysis program POINTER. Genetic Epidemiology. 11: 385-7. PMID 7813900 DOI: 10.1002/Gepi.1370110408  0.205
1991 Shields DC, Collins A, Buetow KH, Morton NE. Error filtration, interference, and the human linkage map. Proceedings of the National Academy of Sciences of the United States of America. 88: 6501-5. PMID 1862077 DOI: 10.1073/Pnas.88.15.6501  0.205
2017 Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, ... ... Shields DC, et al. Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics. 49: 1558. PMID 28951623 DOI: 10.1038/Ng1017-1558A  0.197
1997 Jensen LE, Hiney MP, Shields DC, Uhlar CM, Lindsay AJ, Whitehead AS. Acute Phase Proteins in Salmonids: Evolutionary Analyses and Acute Phase Response Journal of Immunology. 158: 384-392. PMID 8977214  0.193
1993 Sham PC, Morton NE, Muir WJ, Walker M, Collins A, Shields DC, Clair DMS, Blackwood DHR. Segregation analysis of complex phenotypes: An application to schizophrenia and auditory P300 latency Schizophrenia Research. 9: 123-124. DOI: 10.1016/0920-9964(93)90187-N  0.189
2004 Maree AO, Curtin R, Dooley M, Crean P, Shields D, Cox D, Fitzgerald DJ. 404-2 Aspirin resistance in cardiovascular disease: underdosing of overweight patients Journal of the American College of Cardiology. 43: A532. DOI: 10.1016/S0735-1097(04)92256-5  0.182
1996 Müsch A, Xu H, Shields D, Rodriguez-Boulan E. Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells. The Journal of Cell Biology. 133: 543-58. PMID 8636230 DOI: 10.1083/Jcb.133.3.543  0.179
2015 Duffy FJ, Devocelle M, Shields DC. Computational approaches to developing short cyclic peptide modulators of protein–protein interactions Methods in Molecular Biology. 1268: 241-271. DOI: 10.1007/978-1-4939-2285-7_11  0.178
2011 Casey F, Krogan N, Shields DC, Cagney G. Distinct configurations of protein complexes and biochemical pathways revealed by epistatic interaction network motifs Bmc Systems Biology. 5. DOI: 10.1186/1752-0509-5-133  0.171
2011 Khaldi N, Shields DC. Shift in the isoelectric-point of milk proteins as a consequence of adaptive divergence between the milks of mammalian species Biology Direct. 6. DOI: 10.1186/1745-6150-6-40  0.166
2021 Um J, Manguy J, Anes J, Jacquier JC, Hurley D, Dillon ET, Wynne K, Fanning S, O'Sullivan M, Shields DC. Enriching antimicrobial peptides from milk hydrolysates using pectin/alginate food-gels. Food Chemistry. 352: 129220. PMID 33684717 DOI: 10.1016/j.foodchem.2021.129220  0.164
1984 Green R, Shields D. Somatostatin discriminates between the intracellular pathways of secretory and membrane proteins. The Journal of Cell Biology. 99: 97-104. PMID 6145720 DOI: 10.1083/jcb.99.1.97  0.149
1989 Stoller TJ, Shields D. The propeptide of preprosomatostatin mediates intracellular transport and secretion of α-globin from mammalian cells Journal of Cell Biology. 108: 1647-1655. PMID 2565905 DOI: 10.1083/Jcb.108.5.1647  0.146
1998 Banik NL, Shields DC, Ray S, Davis B, Matzelle D, Wilford G, Hogan EL. Role of calpain in spinal cord injury: effects of calpain and free radical inhibitors. Annals of the New York Academy of Sciences. 844: 131-7. PMID 9668671 DOI: 10.1111/j.1749-6632.1998.tb08228.x  0.141
1998 Mynett-Johnson LA, Murphy VE, Claffey E, Shields DC, McKeon P. Preliminary evidence of an association between bipolar disorder in females and the catechol-O-methyltransferase gene Psychiatric Genetics. 8: 221-225. PMID 9861640  0.137
1999 Shields DC, Banik NL. Pathophysiological role of calpain in experimental demyelination Journal of Neuroscience Research. 55: 533-541. PMID 10082076 DOI: 10.1002/(Sici)1097-4547(19990301)55:5<533::Aid-Jnr1>3.0.Co;2-8  0.135
2022 Klatte N, Shields DC, Agoni C. Modelling the Transitioning of SARS-CoV-2 nsp3 and nsp4 Lumenal Regions towards a More Stable State on Complex Formation. International Journal of Molecular Sciences. 24. PMID 36614163 DOI: 10.3390/ijms24010720  0.131
2021 Cotroneo CE, Gormley IC, Shields DC, Salter-Townshend M. Computational modelling of chromosomally clustering protein domains in bacteria. Bmc Bioinformatics. 22: 593. PMID 34906073 DOI: 10.1186/s12859-021-04512-x  0.129
1993 Xu H, Shields D. Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells. The Journal of Cell Biology. 122: 1169-84. PMID 8104189 DOI: 10.1083/Jcb.122.6.1169  0.127
2010 Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, Hastie CE, Menni C, Monti MC, Delles C, Laing S, Corso B, Navis G, Kwakernaak AJ, van der Harst P, ... ... Shields DC, et al. Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. Plos Genetics. 6: e1001177. PMID 21082022 DOI: 10.1371/journal.pgen.1001177  0.12
1998 Shields DC, Banik NL. Upregulation of calpain activity and expression in experimental allergic encephalomyelitis: A putative role for calpain in demyelination Brain Research. 794: 68-74. PMID 9630523 DOI: 10.1016/S0006-8993(98)00193-0  0.117
2001 Schaecher KE, Shields DC, Banik NL. Mechanism of myelin breakdown in experimental demyelination: a putative role for calpain. Neurochemical Research. 26: 731-7. PMID 11519732 DOI: 10.1023/A:1010903823668  0.116
1996 Shields DC, Harmon DL, Whitehead AS. Evolution of hemopoietic ligands and their receptors: Influence of positive selection on correlated replacements throughout ligand and receptor proteins Journal of Immunology. 156: 1062-1070. PMID 8557980  0.114
1999 Shields DC, Schaecher KE, Saido TC, Banik NL. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proceedings of the National Academy of Sciences of the United States of America. 96: 11486-91. PMID 10500203 DOI: 10.1073/Pnas.96.20.11486  0.104
2014 Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, ... ... Shields DC, et al. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Communications. 5: 5068. PMID 25350695 DOI: 10.1038/ncomms6068  0.099
2004 Moore N, Stojanovic M, Lyons S, OBrien E, Shields D, OBrien J, Stanton A. A NEWLY DISCOVERED POLYMORPHISM IN THE RENIN GENE ENHANCER REGION IS ASSOCIATED WITH ELEVATED AMBULATORY BP LEVELS IN A URGE COMMUNITY POPULATION Journal of Hypertension. 22: S178. DOI: 10.1097/00004872-200402001-00756  0.094
1997 Shields DC, Leblanc C, Banik NL. Calcium-mediated neurofilament protein degradation in rat optic nerve in vitro: Activity and autolysis of calpain proenzyme Experimental Eye Research. 65: 15-21. PMID 9237860 DOI: 10.1006/Exer.1997.0286  0.082
1998 Shields DC, Banik NL. Putative role of calpain in the pathophysiology of experimental optic neuritis Experimental Eye Research. 67: 403-410. PMID 9820787 DOI: 10.1006/Exer.1998.0537  0.081
1992 Collins A, Keats BJ, Dracopoli N, Shields DC, Morton NE. Integration of gene maps: chromosome 1. Proceedings of the National Academy of Sciences of the United States of America. 89: 4598-602. PMID 1584796 DOI: 10.1073/pnas.89.10.4598  0.078
1998 Shields DC, Tyor WR, Deibler GE, Hogan EL, Banik NL. Increased calpain expression in activated glial and inflammatory cells in experimental allergic encephalomyelitis. Proceedings of the National Academy of Sciences of the United States of America. 95: 5768-72. PMID 9576959 DOI: 10.1073/Pnas.95.10.5768  0.078
2000 Banik NL, Shields DC. The role of calpain in neurofilament protein degradation associated with spinal cord injury. Methods in Molecular Biology (Clifton, N.J.). 144: 195-201. PMID 10818764 DOI: 10.1385/1-59259-050-0:195  0.078
1997 Banik NL, Shields DC, Ray S, Gantt-Wilford G. Calpain gene expression in rat CNS regions Faseb Journal. 11: A1224.  0.069
1999 Shields DC, Schaecher KE, Goust JM, Banik NL. Calpain activity and expression are increased in splenic inflammatory cells associated with experimental allergic encephalomyelitis Journal of Neuroimmunology. 99: 1-12. PMID 10496171 DOI: 10.1016/S0165-5728(99)00043-0  0.068
1998 Shields DC, Tyor WR, Deibler GE, Banik NL. Increased calpain expression in experimental demyelinating optic neuritis: An immunocytochemical study Brain Research. 784: 299-304. PMID 9518658 DOI: 10.1016/S0006-8993(97)01381-4  0.067
2014 Khaldi N, Vijayakumar V, Dallas DC, Guerrero A, Wickramasinghe S, Smilowitz JT, Medrano JF, Lebrilla CB, Shields DC, German JB. Predicting the important enzymes in human breast milk digestion Journal of Agricultural and Food Chemistry. 62: 7225-7232. DOI: 10.1021/jf405601e  0.063
2015 Young RM, Leiphart JW, Shields DC, Caputy AJ. Anterior cervical fusion versus minimally invasive posterior keyhole decompression for cervical radiculopathy Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 2: 169-176. DOI: 10.1016/J.Inat.2015.08.002  0.063
2007 Shields DC, Sharma N, Gale JT, Eskandar EN. Pallidal stimulation for dystonia in pantothenate kinase-associated neurodegeneration. Pediatric Neurology. 37: 442-5. PMID 18021929 DOI: 10.1016/J.Pediatrneurol.2007.08.006  0.061
1998 Shields DC, Ray SK, Gantt-Wilford G, Banik NL. Calpain expression varies among different rat and bovine central nervous system regions Journal of Neuroscience Research. 53: 482-489. PMID 9710268 DOI: 10.1002/(Sici)1097-4547(19980815)53:4<482::Aid-Jnr10>3.0.Co;2-4  0.061
2000 Shields DC, Schaecher KE, Hogan EL, Banik NL. Calpain activity and expression increased in activated glial and inflammatory cells in penumbra of spinal cord injury lesion. Journal of Neuroscience Research. 61: 146-50. PMID 10878587 DOI: 10.1002/1097-4547(20000715)61:2<146::Aid-Jnr5>3.0.Co;2-C  0.058
1996 Bormann EG, Cragan JF, Shields DC. An expansion of the rhetorical vision component of the symbolic convergence theory: The Cold War paradigm case Communication Monographs. 63: X-28. DOI: 10.1080/03637759609376371  0.058
2008 Shields DC, Asaad W, Eskandar EN, Jain FA, Cosgrove GR, Flaherty AW, Cassem EH, Price BH, Rauch SL, Dougherty DD. Prospective assessment of stereotactic ablative surgery for intractable major depression. Biological Psychiatry. 64: 449-54. PMID 18486107 DOI: 10.1016/J.Biopsych.2008.04.009  0.054
1993 Spurr NK, Cox S, Bryant SP, Attwood J, Robson EB, Shields DC, Steinbrueck T, Jenkins T, Murray JC, Kidd KK. The CEPH consortium linkage map of human chromosome 2. Genomics. 14: 1055-63. PMID 1478647 DOI: 10.1016/s0888-7543(05)80129-6  0.054
2009 Gorgulho AA, Shields DC, Malkasian D, Behnke E, DeSalles AAF. Stereotactic coordinates associated with facial musculature contraction during high-frequency stimulation of the subthalamic nucleus: Clinical article Journal of Neurosurgery. 110: 1317-1321. PMID 19284244 DOI: 10.3171/JNS.2008.10.JNS08835  0.052
2007 Shields DC, Leiphart JW, McArthur DL, Vespa PM, LeVan Quyen M, Martinerie J, Soss JR. Cortical synchrony changes detected by scalp electrode electroencephalograph as traumatic brain injury patients emerge from coma. Surgical Neurology. 67: 354-9. PMID 17350400 DOI: 10.1016/J.Surneu.2006.09.036  0.05
1998 Beckett GA, Galena R, Shields D, Mills DA. Maine removed criminal penalties for syringe possession in 1997 after allowing sale of syringes without a prescription in 1993 [6] Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 18. PMID 9663642 DOI: 10.1097/00042560-199802001-00028  0.047
2008 Shields DC, Cheng ML, Flaherty AW, Gale JT, Eskandar EN. Microelectrode-guided deep brain stimulation for Tourette syndrome: within-subject comparison of different stimulation sites. Stereotactic and Functional Neurosurgery. 86: 87-91. PMID 18073521 DOI: 10.1159/000112429  0.046
2014 Leiphart JW, Young RM, Shields DC. A historical perspective: stereotactic lesions for the treatment of epilepsy. Seizure. 23: 1-5. PMID 24216485 DOI: 10.1016/J.Seizure.2013.10.006  0.044
2014 Gale JT, Shields DC, Ishizawa Y, Eskandar EN. Reward and reinforcement activity in the nucleus accumbens during learning. Frontiers in Behavioral Neuroscience. 8: 114. PMID 24765069 DOI: 10.3389/Fnbeh.2014.00114  0.042
2013 Samantaray S, Knaryan VH, Shields DC, Banik NL. Critical role of calpain in spinal cord degeneration in Parkinson's disease. Journal of Neurochemistry. 127: 880-90. PMID 23875735 DOI: 10.1111/Jnc.12374  0.041
2000 Ray SK, Schaecher KE, Shields DC, Hogan EL, Banik NL. Combined TUNEL and double immunofluorescent labeling for detection of apoptotic mononuclear phagocytes in autoimmune demyelinating disease. Brain Research. Brain Research Protocols. 5: 305-11. PMID 10906497 DOI: 10.1016/S1385-299X(00)00027-1  0.041
2011 Shields DC, Flaherty AW, Eskandar EN, Williams ZM. Ventral intermediate thalamic stimulation for monoclonal gammopathy-associated tremor: case report. Neurosurgery. 68: E1464-7. PMID 21311371 DOI: 10.1227/NEU.0b013e3182124633  0.04
2015 Samantaray S, Knaryan VH, Shields DC, Cox AA, Haque A, Banik NL. Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice. Molecular Neurobiology. 52: 1054-66. PMID 26108182 DOI: 10.1007/S12035-015-9255-6  0.038
1999 Ray SK, Shields DC, Saido TC, Matzelle DC, Wilford GG, Hogan EL, Banik NL. Calpain activity and translational expression increased in spinal cord injury. Brain Research. 816: 375-80. PMID 9878837 DOI: 10.1016/S0006-8993(98)01128-7  0.038
2000 Shields DC, Avgeropoulos NG, Banik NL, Tyor WR. Acute multiple sclerosis characterized by extensive mononuclear phagocyte infiltration. Neurochemical Research. 25: 1517-20. PMID 11071372 DOI: 10.1023/A:1007636427861  0.037
2007 Shields DC, Gorgulho A, Behnke E, Malkasian D, DeSalles AA. Contralateral conjugate eye deviation during deep brain stimulation of the subthalamic nucleus. Journal of Neurosurgery. 107: 37-42. PMID 17639871 DOI: 10.3171/JNS-07/07/0037  0.037
2000 O'Connor FF, Shields DC, Fitzgerald DJ. Factor v leiden and thermolabile mthfr and the response to the oral glycoprotein (gp) hbmiia antagonist orbofiban in acute coronary syndromes Blood. 96: 53a.  0.035
2000 Hillmann A, Shields DC, Fitzgerald DJ, Kenny D. Polymorphisms in glycoprotein (GP) 1b alpha are not associated with adverse outcomes in primigravidae Journal of Obstetrics and Gynaecology. 20: 250-255.  0.034
1997 Shields DC, Deibler GE, Banik NL. Calpain, a mediator of myelin breakdown in demyelinating diseases Annals of the New York Academy of Sciences. 825: 128-133. PMID 9369981 DOI: 10.1111/J.1749-6632.1997.Tb48422.X  0.034
2009 Gale JT, Shields DC, Jain FA, Amirnovin R, Eskandar EN. Subthalamic nucleus discharge patterns during movement in the normal monkey and Parkinsonian patient. Brain Research. 1260: 15-23. PMID 19167367 DOI: 10.1016/J.Brainres.2008.12.062  0.033
2007 Shields DC, Costello DJ, Gale JT, Hoch DB, Eskandar EN. Stereotactic cortical resection in non-lesional extra-temporal partial epilepsy. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 14: 1186-8. PMID 17708755 DOI: 10.1111/J.1468-1331.2007.01920.X  0.031
2015 Bergey GK, Morrell MJ, Mizrahi EM, Goldman A, King-Stephens D, Nair D, Srinivasan S, Jobst B, Gross RE, Shields DC, Barkley G, Salanova V, Olejniczak P, Cole A, Cash SS, et al. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology. 84: 810-7. PMID 25616485 DOI: 10.1212/Wnl.0000000000001280  0.03
1999 Cragan JF, Shields DC. Translating scholarship into practice: Communication studies reflecting the value of theory-based research to everyday life Journal of Applied Communication Research. 27: 92-106.  0.028
2005 Waters MF, Shields DC, Martin NA, Baloh RW, Jen JC. Novel CCM1 mutation in a patient with paraparesis and thoracic cord cavernous malformation. Neurology. 65: 966-7. PMID 16186553 DOI: 10.1212/01.wnl.0000175976.95737.76  0.027
2001 Banik NL, Shields DC. Calpain expression upregulated in activated glial and inflammatory cells in experimental optic neuritis Research Communications in Pharmacology and Toxicology. 6: 93-106.  0.025
2015 King-Stephens D, Mirro E, Weber PB, Laxer KD, Van Ness PC, Salanova V, Spencer DC, Heck CN, Goldman A, Jobst B, Shields DC, Bergey GK, Eisenschenk S, Worrell GA, Rossi MA, et al. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia. 56: 959-67. PMID 25988840 DOI: 10.1111/Epi.13010  0.025
2009 Costello DJ, Shields DC, Cash SS, Eskandar EN, Cosgrove GR, Cole AJ. Consideration of epilepsy surgery in adults should be independent of age. Clinical Neurology and Neurosurgery. 111: 240-5. PMID 19028008 DOI: 10.1016/J.Clineuro.2008.10.005  0.02
2000 Shields DC. Symbolic convergence and special communication theories: Sensing and examining dis/enchantment with the theoretical robustness of critical autoethnography Communication Monographs. 67: 392-421.  0.018
2000 Csapó-Sweet RM, Shields DC. Explicating the saga component of symbolic convergence theory: The case of Serbia's Radio B92 in cyberspace Critical Studies in Media Communication. 17: 316-333.  0.018
2006 Shields DC, Lam S, Gorgulho A, Emerson J, Krahl SE, Malkasian D, DeSalles AA. Eyelid apraxia associated with subthalamic nucleus deep brain stimulation. Neurology. 66: 1451-2. PMID 16682687 DOI: 10.1212/01.wnl.0000210693.13093.c8  0.016
2005 Shields DC, Palma C, Khoo LT, Ferrante FM. Extramedullary intrathecal catheter granuloma adherent to the conus medullaris presenting as cauda equina syndrome. Anesthesiology. 102: 1059-61. PMID 15851894 DOI: 10.1097/00000542-200505000-00026  0.016
2015 Samantaray S, Knaryan VH, Shields DC, Cox AA, Haque A, Banik NL. Inhibition of Calpain Activation Protects MPTP-Induced Nigral and Spinal Cord Neurodegeneration, Reduces Inflammation, and Improves Gait Dynamics in Mice Molecular Neurobiology. DOI: 10.1007/s12035-015-9255-6  0.015
2013 Samantaray S, Knaryan VH, Shields DC, Banik NL. Critical role of calpain in spinal cord degeneration in Parkinson's disease Journal of Neurochemistry. 127: 880-890. DOI: 10.1111/jnc.12374  0.015
2008 Shields DC. Commentary Surgical Neurology. 69: 80. DOI: 10.1016/j.surneu.2007.01.023  0.01
2010 Shields DC. A model for a sustainable urban community Water and Wastes Digest. 50: 46-47.  0.01
2011 Shields DC. A public-private partnership: American Water's revolutionary water reuse system for the Patriots' home Global Business and Organizational Excellence. 30: 56-63. DOI: 10.1002/joe.20395  0.01
2003 Bormann EG, Cragan JF, Shields DC, Gunn J. Defending Symbolic Convergence Theory from an Imaginary Gunn Quarterly Journal of Speech. 89: 366-373. DOI: 10.1080/0033563032000160990  0.01
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