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Gustav Akk, PhD - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
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129 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Tae HS, Ortells MO, Yousuf A, Xu SQ, Akk G, Adams DJ, Arias HR. Tabernanthalog and ibogainalog inhibit the α7 and α9α10 nicotinic acetylcholine receptors via different mechanisms and with higher potency than the GABA receptor and Ca2.2 channel. Biochemical Pharmacology. 116183. PMID 38580167 DOI: 10.1016/j.bcp.2024.116183  0.459
2024 Germann AL, Xu Y, Covey DF, Evers AS, Akk G. Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay. Acs Chemical Neuroscience. PMID 38386612 DOI: 10.1021/acschemneuro.3c00836  0.36
2023 Pohl F, Germann AL, Mao J, Hou S, Bakare B, Kong Thoo Lin P, Yates K, Nonet ML, Akk G, Kornfeld K, Held JM. UNC-49 is a redox-sensitive GABA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously. Science Advances. 9: eadh2584. PMID 37910615 DOI: 10.1126/sciadv.adh2584  0.312
2023 Pierce SR, Xu SQ, Germann AL, Steinbach JH, Akk G. Potentiation of the GABAR reveals variable energetic contributions by etiocholanolone and propofol. Biophysical Journal. PMID 37752702 DOI: 10.1016/j.bpj.2023.09.014  0.476
2023 Arias HR, Pierce SR, Germann AL, Xu SQ, Ortells MO, Sakamoto S, Manetti D, Romanelli MN, Hamachi I, Akk G. . Molecular Pharmacology. PMID 37316350 DOI: 10.1124/molpharm.123.000692  0.428
2023 Pierce SR, Germann AL, Xu SQ, Menon SL, Ortells MO, Arias HR, Akk G. Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABA Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor. Biomolecules. 13. PMID 37189445 DOI: 10.3390/biom13040698  0.452
2023 Tateiwa H, Chintala SM, Chen Z, Wang L, Amtashar F, Bracamontes J, Germann AL, Pierce SR, Covey DF, Akk G, Evers AS. The Mechanism of Enantioselective Neurosteroid Actions on GABA Receptors. Biomolecules. 13. PMID 36830708 DOI: 10.3390/biom13020341  0.419
2022 Arias HR, Germann AL, Pierce SR, Sakamoto S, Ortells MO, Hamachi I, Akk G. Modulation of the mammalian GABA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor. British Journal of Pharmacology. PMID 36082615 DOI: 10.1111/bph.15948  0.433
2022 Germann AL, Burbridge AB, Pierce SR, Akk G. Activation of the Rat α1β2ε GABA Receptor by Orthosteric and Allosteric Agonists. Biomolecules. 12. PMID 35883422 DOI: 10.3390/biom12070868  0.523
2022 Arias HR, Borghese CM, Germann AL, Pierce SR, Bonardi A, Nocentini A, Gratteri P, Thodati TM, Lim NJ, Harris RA, Akk G. (+)-Catharanthine potentiates the GABA receptor by binding to a transmembrane site at the β(+)/α(-) interface near the TM2-TM3 loop. Biochemical Pharmacology. 199: 114993. PMID 35304861 DOI: 10.1016/j.bcp.2022.114993  0.304
2022 Pierce SR, Germann AL, Steinbach JH, Akk G. The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the 132L GABA Receptor by Stabilizing a Novel Nonconducting State. Molecular Pharmacology. 101: 68-77. PMID 34853153 DOI: 10.1124/molpharm.121.000385  0.458
2021 Pierce SR, Germann AL, Akk G. Activation of the α1β2γ2L GABA Receptor by Physiological Agonists. Biomolecules. 11. PMID 34944508 DOI: 10.3390/biom11121864  0.47
2021 Deba F, Munoz K, Peredia E, Akk G, Hamouda AK. Assessing potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor by the allosteric agonist CMPI. The Journal of Biological Chemistry. 298: 101455. PMID 34861241 DOI: 10.1016/j.jbc.2021.101455  0.341
2021 Wang L, Covey DF, Akk G, Evers AS. Neurosteroid modulation of GABAA receptor function by independent action at multiple specific binding sites. Current Neuropharmacology. PMID 34856904 DOI: 10.2174/1570159X19666211202150041  0.448
2021 Germann AL, Pierce SR, Evers AS, Steinbach JH, Akk G. Perspective on the relationship between GABAA receptor activity and the apparent potency of an inhibitor. Current Neuropharmacology. PMID 34784870 DOI: 10.2174/1570159X19666211104142433  0.365
2021 Germann AL, Pierce SR, Tateiwa H, Sugasawa Y, Reichert DE, Evers AS, Steinbach JH, Akk G. Intrasubunit and intersubunit steroid binding sites independently and additively mediate α1β2γ2L GABA receptor potentiation by the endogenous neurosteroid allopregnanolone. Molecular Pharmacology. PMID 33958479 DOI: 10.1124/molpharm.121.000268  0.361
2020 Pierce SR, Germann AL, Evers AS, Steinbach JH, Akk G. Reduced activation of the synaptic-type GABA receptor following prolonged exposure to low concentrations of agonists: relationship between tonic activity and desensitization. Molecular Pharmacology. PMID 32978327 DOI: 10.1124/molpharm.120.000088  0.451
2020 Sugasawa Y, Cheng WW, Bracamontes JR, Chen ZW, Wang L, Germann AL, Pierce SR, Senneff TC, Krishnan K, Reichert DE, Covey DF, Akk G, Evers AS. Site-specific effects of neurosteroids on GABA receptor activation and desensitization. Elife. 9. PMID 32955433 DOI: 10.7554/Elife.55331  0.529
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA Receptor: Relating Occupancy to State Functions. Molecular Pharmacology. 98: 303-313. PMID 32873746 DOI: 10.1124/Molpharm.120.000066  0.55
2020 Akk G, Germann AL, Sugasawa Y, Pierce SR, Evers AS, Steinbach JH. Enhancement of muscimol binding and gating by allosteric modulators of the GABA receptor: relating occupancy to state functions. Molecular Pharmacology. PMID 32723768 DOI: 10.1124/molpharm.120.000066  0.468
2020 Germann AL, Reichert DE, Burbridge AB, Pierce SR, Evers AS, Steinbach JH, Akk G. Analysis of modulation of the ρ1 GABAA receptor by combinations of inhibitory and potentiating neurosteroids reveals shared and distinct binding sites. Molecular Pharmacology. PMID 32675382 DOI: 10.1124/Mol.120.119842  0.591
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03706  0.42
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03706  0.312
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03706  0.312
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03706  0.312
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03706  0.312
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03706  0.312
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03706  0.312
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03706  0.312
2020 Deba F, Akk G, Hamouda AK. Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod‐Wyman‐Changeux allosteric model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.03706  0.312
2019 Sun MY, Ziolkowski L, Lambert P, Shu HJ, Keiser M, Rensing N, Warikoo N, Martinek M, Platnick C, Benz A, Bracamontes J, Akk G, Steinbach JH, Zorumski CF, Wong M, et al. Mild chronic perturbation of inhibition severely alters hippocampal function. Scientific Reports. 9: 16431. PMID 31712706 DOI: 10.1038/S41598-019-52851-W  0.481
2019 Pierce SR, Senneff TC, Germann AL, Akk G. Steady-state activation of the high-affinity isoform of the α4β2δ GABA receptor. Scientific Reports. 9: 15997. PMID 31690811 DOI: 10.1038/S41598-019-52573-Z  0.556
2019 Germann AL, Pierce SR, Senneff TC, Burbridge AB, Steinbach JH, Akk G. Steady-state activation and modulation of the synaptic-type α1β2γ2L GABA receptor by combinations of physiological and clinical ligands. Physiological Reports. 7: e14230. PMID 31549483 DOI: 10.14814/Phy2.14230  0.496
2019 Germann AL, Pierce SR, Burbridge AB, Steinbach JH, Akk G. Steady-state activation and modulation of the concatemeric α1β2γ2L GABAA receptor. Molecular Pharmacology. PMID 31263018 DOI: 10.1124/Mol.119.116913  0.48
2019 Sugasawa Y, Bracamontes JR, Krishnan K, Covey DF, Reichert DE, Akk G, Chen Q, Tang P, Evers AS, Cheng WWL. The Molecular Determinants of Neurosteroid Binding in the GABA(A) Receptor. The Journal of Steroid Biochemistry and Molecular Biology. 105383. PMID 31150831 DOI: 10.1016/J.Jsbmb.2019.105383  0.49
2019 Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS. Multiple functional neurosteroid binding sites on GABAA receptors. Plos Biology. 17: e3000157. PMID 30845142 DOI: 10.1371/Journal.Pbio.3000157  0.473
2018 Germann AL, Steinbach JH, Akk G. Application of the Co-Agonist Concerted Transition Model to Analysis of GABAA Receptor Properties. Current Neuropharmacology. PMID 30520374 DOI: 10.2174/1570159X17666181206092418  0.552
2018 Shin DJ, Germann AL, Covey DF, Steinbach JH, Akk G. Analysis of GABAA receptor activation by combinations of agonists acting at the same or distinct binding sites. Molecular Pharmacology. PMID 30337372 DOI: 10.1124/Mol.118.113464  0.572
2018 Steinbach JH, Akk G. APPLYING THE MONOD-WYMAN-CHANGEUX ALLOSTERIC ACTIVATION MODEL TO PSEUDO-STEADY-STATE RESPONSES FROM GABAA RECEPTORS. Molecular Pharmacology. PMID 30333132 DOI: 10.1124/Mol.118.113787  0.542
2018 Sun MY, Shu HJ, Benz A, Bracamontes J, Akk G, Zorumski CF, Steinbach JH, Mennerick S. Chemogenetic isolation reveals synaptic contribution of δ GABA receptors in mouse dentate granule neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30076210 DOI: 10.1523/Jneurosci.0799-18.2018  0.572
2018 Cao LQ, Montana MC, Germann AL, Shin DJ, Chakrabarti S, Mennerick S, Yuede CM, Wozniak DF, Evers AS, Akk G. Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam. Scientific Reports. 8: 10341. PMID 29985445 DOI: 10.1038/S41598-018-28754-7  0.668
2018 Germann A, Shin D, Kuhrau C, Johnson A, Evers AS, Akk G. High constitutive activity accounts for the combination of enhanced direct activation and reduced potentiation in mutated GABAA receptors. Molecular Pharmacology. PMID 29439087 DOI: 10.1124/Mol.117.111435  0.556
2018 Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS. Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC. The Journal of Biological Chemistry. PMID 29301936 DOI: 10.1074/Jbc.Ra117.000359  0.46
2018 Cheng WW, Chen Z, John BR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS. Mapping Two Neursteroid Modulatory Sites in GLIC: A Prototypic Pentameric Ligand Gated Ion Channel Biophysical Journal. 114: 299a. DOI: 10.1016/J.Bpj.2017.11.1704  0.357
2017 Shin DJ, Germann AL, Johnson AD, Forman SA, Steinbach JH, Akk G. Propofol is an allosteric agonist with multiple binding sites on concatemeric ternary GABAA receptors. Molecular Pharmacology. PMID 29192122 DOI: 10.1124/Mol.117.110403  0.518
2017 Akk G, Shin DJ, Germann AL, Steinbach JH. GABAA receptor activation in the allosteric coagonist model framework: relationship between EC50 and basal activity. Molecular Pharmacology. PMID 29150461 DOI: 10.1124/Mol.117.110569  0.535
2017 Shin DJ, Germann AL, Steinbach JH, Akk G. The actions of drug combinations on the GABAA receptor manifest as curvilinear isoboles of additivity. Molecular Pharmacology. PMID 28790148 DOI: 10.1124/Mol.117.109595  0.49
2017 Jin X, Germann AL, Shin DJ, Akk G, Steinbach JH. Determination of the residues in the extracellular domain of the nicotinic α subunit required for the actions of physostigmine on neuronal nicotinic receptors. Molecular Pharmacology. PMID 28630263 DOI: 10.1124/Mol.117.108894  0.46
2016 Jin X, McCollum MM, Germann AL, Akk G, Steinbach JH. The E loop of the transmitter-binding site is a key determinant of the modulatory effects of physostigmine on neuronal nicotinic α4β2 receptors. Molecular Pharmacology. PMID 27895161 DOI: 10.1124/Mol.116.106484  0.48
2016 Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G. Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol. British Journal of Pharmacology. PMID 27459129 DOI: 10.1111/Bph.13566  0.491
2016 Bracamontes JR, Akk G, Steinbach JH. Introduced Amino Terminal Epitopes Can Reduce Surface Expression of Neuronal Nicotinic Receptors. Plos One. 11: e0151071. PMID 26963253 DOI: 10.1371/Journal.Pone.0151071  0.357
2016 Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G. Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors. Molecular Pharmacology. PMID 26769414 DOI: 10.1124/Mol.115.102202  0.737
2016 Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G. Multiple non-equivalent interfaces mediate direct activation of GABAA receptors by propofol Current Neuropharmacology. 14: 772-780. DOI: 10.2174/1570159X14666160202121319  0.371
2016 Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G. Multiple non-equivalent interfaces mediate direct activation of GABAA receptors by propofol Current Neuropharmacology. 14: 772-780. DOI: 10.2174/1570159X14666160202121319  0.371
2015 Eaton MM, Cao LQ, Chen Z, Franks NP, Evers AS, Akk G. Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β3 Homomeric GABAA Receptors. Molecular Pharmacology. 88: 736-45. PMID 26206487 DOI: 10.1124/Mol.115.100347  0.474
2015 Li P, Akk G. Synaptic-type α1β2γ2L GABAA receptors produce large persistent currents in the presence of ambient GABA and anesthetic drugs. Molecular Pharmacology. 87: 776-81. PMID 25667223 DOI: 10.1124/Mol.114.096453  0.48
2014 Eaton MM, Bracamontes J, Shu HJ, Li P, Mennerick S, Steinbach JH, Akk G. γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type. Molecular Pharmacology. 86: 647-56. PMID 25238745 DOI: 10.1124/Mol.114.094813  0.545
2014 Li P, Bracamontes JR, Manion BD, Mennerick S, Steinbach JH, Evers AS, Akk G. The neurosteroid 5β-pregnan-3α-ol-20-one enhances actions of etomidate as a positive allosteric modulator of α1β2γ2L GABAA receptors. British Journal of Pharmacology. 171: 5446-57. PMID 25117207 DOI: 10.1111/Bph.12861  0.544
2014 Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS. 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology. 231: 3479-91. PMID 24756762 DOI: 10.1007/S00213-014-3568-4  0.552
2014 Bracamontes JR, Li P, Akk G, Steinbach JH. Mutations in the main cytoplasmic loop of the GABA(A) receptor α4 and δ subunits have opposite effects on surface expression. Molecular Pharmacology. 86: 20-7. PMID 24723490 DOI: 10.1124/Mol.114.092791  0.467
2014 Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. Journal of Medicinal Chemistry. 57: 171-90. PMID 24328079 DOI: 10.1021/Jm401577C  0.479
2014 Eaton MM, Lim YB, Covey DF, Akk G. Modulation of the human ρ1 GABAA receptor by inhibitory steroids. Psychopharmacology. 231: 3467-78. PMID 24317445 DOI: 10.1007/S00213-013-3379-Z  0.442
2013 Akk G, Eaton M, Li P, Zheng S, Lo J, Steinbach JH. Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. Plos One. 8: e78539. PMID 24194945 DOI: 10.1371/Journal.Pone.0078539  0.515
2013 Li P, Eaton MM, Steinbach JH, Akk G. The benzodiazepine diazepam potentiates responses of α1β2γ2L γ-aminobutyric acid type A receptors activated by either γ-aminobutyric acid or allosteric agonists. Anesthesiology. 118: 1417-25. PMID 23407108 DOI: 10.1097/Aln.0B013E318289Bcd3  0.616
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/J.Bpj.2012.11.3506  0.354
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/J.Bpj.2012.11.3506  0.354
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/j.bpj.2012.11.3506  0.335
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/j.bpj.2012.11.3506  0.335
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/j.bpj.2012.11.3506  0.335
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/j.bpj.2012.11.3506  0.335
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/j.bpj.2012.11.3506  0.335
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/j.bpj.2012.11.3506  0.335
2013 Akk G, Eaton M, Li P, Lo J, Zheng S, Steinbach JH. Energetic Changes in the β Subunit during Gating of the Muscle Nicotinic Receptor Biophysical Journal. 104: 634a. DOI: 10.1016/j.bpj.2012.11.3506  0.335
2012 Bracamontes JR, Li P, Akk G, Steinbach JH. A neurosteroid potentiation site can be moved among GABAA receptor subunits. The Journal of Physiology. 590: 5739-47. PMID 22988137 DOI: 10.1113/Jphysiol.2012.237255  0.566
2012 Tammimäki A, Herder P, Li P, Esch C, Laughlin JR, Akk G, Stitzel JA. Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors. Neuropharmacology. 63: 1002-11. PMID 22820273 DOI: 10.1016/J.Neuropharm.2012.07.022  0.494
2012 Eaton MM, Lim YB, Bracamontes J, Steinbach JH, Akk G. Agonist-specific conformational changes in the α1-γ2 subunit interface of the GABA A receptor. Molecular Pharmacology. 82: 255-63. PMID 22572883 DOI: 10.1124/Mol.112.077875  0.595
2012 Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut LJ, Goate AM. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Human Molecular Genetics. 21: 647-55. PMID 22042774 DOI: 10.1093/Hmg/Ddr498  0.313
2012 Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S. Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. British Journal of Pharmacology. 165: 2228-43. PMID 21950777 DOI: 10.1111/J.1476-5381.2011.01690.X  0.593
2011 Steinbach JH, Akk G. Use of concatemers of ligand-gated ion channel subunits to study mechanisms of steroid potentiation. Anesthesiology. 115: 1328-37. PMID 21926904 DOI: 10.1097/Aln.0B013E318233046A  0.576
2011 Akk G, Steinbach JH. Structural studies of the actions of anesthetic drugs on the γ-aminobutyric acid type A receptor. Anesthesiology. 115: 1338-48. PMID 21881491 DOI: 10.1097/Aln.0B013E3182315D93  0.557
2011 Li P, McCollum M, Bracamontes J, Steinbach JH, Akk G. Functional characterization of the α5(Asn398) variant associated with risk for nicotine dependence in the α3β4α5 nicotinic receptor. Molecular Pharmacology. 80: 818-27. PMID 21856741 DOI: 10.1124/Mol.111.073841  0.511
2011 Li P, Ann J, Akk G. Activation and modulation of human α4β2 nicotinic acetylcholine receptors by the neonicotinoids clothianidin and imidacloprid. Journal of Neuroscience Research. 89: 1295-301. PMID 21538459 DOI: 10.1002/Jnr.22644  0.555
2011 Bracamontes J, McCollum M, Esch C, Li P, Ann J, Steinbach JH, Akk G. Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site. Molecular Pharmacology. 80: 79-86. PMID 21498656 DOI: 10.1124/Mol.111.071662  0.57
2011 Akk G, Li P, Bracamontes J, Wang M, Steinbach JH. Pharmacology of structural changes at the GABA(A) receptor transmitter binding site. British Journal of Pharmacology. 162: 840-50. PMID 20958292 DOI: 10.1111/J.1476-5381.2010.01083.X  0.549
2010 Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH. Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Current Neuropharmacology. 8: 18-25. PMID 20808543 DOI: 10.2174/157015910790909458  0.618
2010 Akk G. Molecular pharmacology of the GABA(A) receptor. Current Neuropharmacology. 8: 1. PMID 20808540 DOI: 10.2174/157015910790909539  0.519
2010 Li P, Khatri A, Bracamontes J, Weiss DS, Steinbach JH, Akk G. Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids. Molecular Pharmacology. 77: 539-46. PMID 20061447 DOI: 10.1016/J.Bpj.2009.12.3859  0.537
2009 Li P, Bandyopadhyaya AK, Covey DF, Steinbach JH, Akk G. Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation. British Journal of Pharmacology. 158: 1322-9. PMID 19702782 DOI: 10.1111/J.1476-5381.2009.00390.X  0.503
2009 Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology. 34: S59-66. PMID 19541427 DOI: 10.1016/J.Psyneuen.2009.05.020  0.592
2009 Akk G, Li P, Bracamontes J, Steinbach JH. Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells. Molecular Pharmacology. 75: 1400-11. PMID 19289569 DOI: 10.1124/Mol.108.054510  0.59
2008 Li P, Akk G. The insecticide fipronil and its metabolite fipronil sulphone inhibit the rat alpha1beta2gamma2L GABA(A) receptor. British Journal of Pharmacology. 155: 783-94. PMID 18660823 DOI: 10.1038/Bjp.2008.309  0.591
2008 Akk G, Li P, Bracamontes J, Reichert DE, Covey DF, Steinbach JH. Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Molecular Pharmacology. 74: 614-27. PMID 18544665 DOI: 10.1124/Mol.108.048520  0.517
2008 Militante J, Ma BW, Akk G, Steinbach JH. Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies. Molecular Pharmacology. 74: 764-76. PMID 18523135 DOI: 10.1124/Mol.108.047134  0.556
2008 Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. Journal of Medicinal Chemistry. 51: 1309-18. PMID 18275132 DOI: 10.1021/Jm701128R  0.487
2008 Akk G, Mennerick S, Steinbach JH. Actions of anesthetics on excitatory transmitter-gated channels. Handbook of Experimental Pharmacology. 53-84. PMID 18175086 DOI: 10.1007/978-3-540-74806-9_3  0.545
2008 Li P, Reichert DE, Rodríguez AD, Manion BD, Evers AS, Eterović VA, Steinbach JH, Akk G. Mechanisms of potentiation of the mammalian GABAA receptor by the marine cembranoid eupalmerin acetate. British Journal of Pharmacology. 153: 598-608. PMID 18037909 DOI: 10.1038/Sj.Bjp.0707597  0.638
2008 Ulrich H, Akk G, Nery AA, Trujillo CA, Rodriguez AD, Eterović VA. Mode of cembranoid action on embryonic muscle acetylcholine receptor. Journal of Neuroscience Research. 86: 93-107. PMID 17868151 DOI: 10.1002/Jnr.21468  0.584
2007 Li P, Shu HJ, Wang C, Mennerick S, Zorumski CF, Covey DF, Steinbach JH, Akk G. Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. The Journal of Physiology. 584: 789-800. PMID 17761771 DOI: 10.1113/Jphysiol.2007.142794  0.505
2007 Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & Therapeutics. 116: 35-57. PMID 17524487 DOI: 10.1016/J.Pharmthera.2007.03.004  0.574
2007 Li P, Bracamontes J, Katona BW, Covey DF, Steinbach JH, Akk G. Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Molecular Pharmacology. 71: 1582-90. PMID 17341652 DOI: 10.1124/Mol.106.033407  0.559
2007 Eisenman LN, Shu HJ, Akk G, Wang C, Manion BD, Kress GJ, Evers AS, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nature Neuroscience. 10: 523-30. PMID 17322875 DOI: 10.1038/Nn1862  0.436
2007 Akk G, Li P, Manion BD, Evers AS, Steinbach JH. Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor. Molecular Pharmacology. 71: 461-72. PMID 17105870 DOI: 10.1124/Mol.106.029942  0.392
2006 Li P, Covey DF, Steinbach JH, Akk G. Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Molecular Pharmacology. 69: 2015-26. PMID 16554408 DOI: 10.1124/Mol.106.022590  0.598
2005 Akk G, Shu HJ, Wang C, Steinbach JH, Zorumski CF, Covey DF, Mennerick S. Neurosteroid access to the GABAA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11605-13. PMID 16354918 DOI: 10.1523/Jneurosci.4173-05.2005  0.527
2005 Akk G, Steinbach JH. Galantamine activates muscle-type nicotinic acetylcholine receptors without binding to the acetylcholine-binding site. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1992-2001. PMID 15728839 DOI: 10.1523/Jneurosci.4985-04.2005  0.53
2005 Akk G, Milescu LS, Heckmann M. Activation of heteroliganded mouse muscle nicotinic receptors. The Journal of Physiology. 564: 359-76. PMID 15718267 DOI: 10.1113/Jphysiol.2004.078535  0.776
2005 Milescu LS, Akk G, Sachs F. Maximum likelihood estimation of ion channel kinetics from macroscopic currents. Biophysical Journal. 88: 2494-515. PMID 15681642 DOI: 10.1529/Biophysj.104.053256  0.706
2005 Steinbach JH, Akk G. Potentiation of GABAA receptors by neurosteroids: Mechanisms and sites International Congress Series. 1283: 21-25. DOI: 10.1016/j.ics.2005.07.077  0.417
2004 Akk G, Bracamontes JR, Covey DF, Evers A, Dao T, Steinbach JH. Neuroactive steroids have multiple actions to potentiate GABAA receptors. The Journal of Physiology. 558: 59-74. PMID 15146041 DOI: 10.1113/Jphysiol.2004.066571  0.498
2004 Akk G, Bracamontes J, Steinbach JH. Activation of GABA(A) receptors containing the alpha4 subunit by GABA and pentobarbital. The Journal of Physiology. 556: 387-99. PMID 14966300 DOI: 10.1113/Jphysiol.2003.058230  0.581
2004 Darbandi-Tonkabon R, Manion BD, Hastings WR, Craigen WJ, Akk G, Bracamontes JR, He Y, Sheiko TV, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. The Journal of Pharmacology and Experimental Therapeutics. 308: 502-11. PMID 14593090 DOI: 10.1124/Jpet.103.058123  0.556
2003 Akk G, Steinbach JH. Activation and block of mouse muscle-type nicotinic receptors by tetraethylammonium. The Journal of Physiology. 551: 155-68. PMID 12824448 DOI: 10.1111/J.1469-7793.2003.00155.X  0.596
2003 Akk G, Steinbach JH. Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function. The Journal of Physiology. 546: 641-6. PMID 12562992 DOI: 10.1113/Jphysiol.2002.032300  0.563
2003 Darbandi-Tonkabon R, Hastings WR, Zeng CM, Akk G, Manion BD, Bracamontes JR, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of Biological Chemistry. 278: 13196-206. PMID 12560326 DOI: 10.1074/Jbc.M213168200  0.491
2002 Akk G. Contributions of the non-alpha subunit residues (loop D) to agonist binding and channel gating in the muscle nicotinic acetylcholine receptor. The Journal of Physiology. 544: 695-705. PMID 12411516 DOI: 10.1113/Jphysiol.2002.029413  0.573
2001 Steinbach JH, Akk G. Modulation of GABA(A) receptor channel gating by pentobarbital. The Journal of Physiology. 537: 715-33. PMID 11744750 DOI: 10.1111/J.1469-7793.2001.00715.X  0.547
2001 Browne SH, Kang J, Akk G, Chiang LW, Schulman H, Huguenard JR, Prince DA. Kinetic and pharmacological properties of GABA(A) receptors in single thalamic neurons and GABA(A) subunit expression. Journal of Neurophysiology. 86: 2312-22. PMID 11698521 DOI: 10.1152/Jn.2001.86.5.2312  0.531
2001 Akk G. Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residues. The Journal of Physiology. 535: 729-40. PMID 11559771 DOI: 10.1111/J.1469-7793.2001.00729.X  0.573
2001 Akk G, Bracamontes J, Steinbach JH. Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit. The Journal of Physiology. 532: 673-84. PMID 11313438 DOI: 10.1111/J.1469-7793.2001.0673E.X  0.567
2001 Sun QQ, Akk G, Huguenard JR, Prince DA. Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. The Journal of Physiology. 531: 81-94. PMID 11179393 DOI: 10.1111/J.1469-7793.2001.0081J.X  0.461
2000 Akk G, Steinbach JH. Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision. The Journal of Physiology. 527: 405-17. PMID 10990529 DOI: 10.1111/J.1469-7793.2000.T01-2-00405.X  0.586
2000 Akk G, Steinbach JH. Activation and block of recombinant GABA(A) receptors by pentobarbitone: a single-channel study. British Journal of Pharmacology. 130: 249-58. PMID 10807661 DOI: 10.1038/Sj.Bjp.0703335  0.576
1999 Akk G, Auerbach A. Activation of muscle nicotinic acetylcholine receptor channels by nicotinic and muscarinic agonists. British Journal of Pharmacology. 128: 1467-76. PMID 10602325 DOI: 10.1038/Sj.Bjp.0702941  0.674
1999 Akk G, Zhou M, Auerbach A. A mutational analysis of the acetylcholine receptor channel transmitter binding site. Biophysical Journal. 76: 207-18. PMID 9876135 DOI: 10.1016/S0006-3495(99)77190-0  0.648
1998 Auerbach A, Akk G. Desensitization of mouse nicotinic acetylcholine receptor channels. A two-gate mechanism. The Journal of General Physiology. 112: 181-97. PMID 9689026 DOI: 10.1085/Jgp.112.2.181  0.676
1996 Akk G, Sine S, Auerbach A. Binding sites contribute unequally to the gating of mouse nicotinic alpha D200N acetylcholine receptors. The Journal of Physiology. 496: 185-96. PMID 8910207 DOI: 10.1113/Jphysiol.1996.Sp021676  0.572
1996 Auerbach A, Sigurdson W, Chen J, Akk G. Voltage dependence of mouse acetylcholine receptor gating: different charge movements in di-, mono- and unliganded receptors. The Journal of Physiology. 494: 155-70. PMID 8814613 DOI: 10.1113/Jphysiol.1996.Sp021482  0.675
1996 Akk G, Auerbach A. Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophysical Journal. 70: 2652-8. PMID 8744302 DOI: 10.1016/S0006-3495(96)79834-X  0.672
1995 Chen J, Zhang Y, Akk G, Sine S, Auerbach A. Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating. Biophysical Journal. 69: 849-59. PMID 8519985 DOI: 10.1016/S0006-3495(95)79959-3  0.671
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