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Jon Sack - Publications

Affiliations: 
University of California, Davis, Davis, CA 
Area:
single channels
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65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Stewart RG, Marquis MJ, Jo S, Ferns M, Sack JT. KvS regulatory subunits confer drug resistance to Kv2 channels. Biorxiv : the Preprint Server For Biology. PMID 38352561 DOI: 10.1101/2024.01.31.578214  0.531
2024 Ferns M, van der List D, Vierra NC, Lacey T, Murray K, Kirmiz M, Stewart RG, Sack JT, Trimmer JS. Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function. Biorxiv : the Preprint Server For Biology. PMID 38328147 DOI: 10.1101/2024.01.25.577135  0.48
2023 Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of hERG channel-drug interactions using Rosetta. Frontiers in Pharmacology. 14: 1244166. PMID 38035013 DOI: 10.3389/fphar.2023.1244166  0.449
2023 Kimball IH, Nguyen PT, Olivera BM, Sack JT, Yarov-Yarovoy V. Molecular determinants of μ-conotoxin KIIIA interaction with the human voltage-gated sodium channel Na1.7. Frontiers in Pharmacology. 14: 1156855. PMID 37007002 DOI: 10.3389/fphar.2023.1156855  0.429
2022 Nguyen PT, Nguyen HM, Wagner KM, Stewart R, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, et al. Computational design of peptides to target Na1.7 channel with high potency and selectivity for the treatment of pain. Elife. 11. PMID 36576241 DOI: 10.7554/eLife.81727  0.306
2022 Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Frontiers in Pharmacology. 13: 966463. PMID 36188564 DOI: 10.3389/fphar.2022.966463  0.459
2022 Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Molecular Pharmacology. PMID 36041862 DOI: 10.1124/molpharm.122.000569  0.445
2022 Marquis MJ, Sack JT. Mechanism of use-dependent Kv2 channel inhibition by RY785. The Journal of General Physiology. 154. PMID 35435946 DOI: 10.1085/jgp.202112981  0.552
2022 Sepela RJ, Stewart RG, Valencia LA, Thapa P, Wang Z, Cohen BE, Sack JT. The AMIGO1 adhesion protein activates Kv2.1 voltage sensors. Biophysical Journal. PMID 35314141 DOI: 10.1016/j.bpj.2022.03.020  0.767
2022 Sack JT. K takes the crown: Selective activation of non-selective crown ether channels. Biophysical Journal. 121: 863-864. PMID 35219397 DOI: 10.1016/j.bpj.2022.02.020  0.318
2021 Thapa P, Stewart R, Sepela RJ, Vivas O, Parajuli LK, Lillya M, Fletcher-Taylor S, Cohen BE, Zito K, Sack JT. EVAP: A two-photon imaging tool to study conformational changes in endogenous Kv2 channels in live tissues. The Journal of General Physiology. 153. PMID 34581724 DOI: 10.1085/jgp.202012858  0.778
2021 Stewart R, Cohen BE, Sack JT. Fluorescent toxins as ion channel activity sensors. Methods in Enzymology. 653: 295-318. PMID 34099176 DOI: 10.1016/bs.mie.2021.02.014  0.559
2021 Maly J, Emigh AM, DeMarco K, Sack JT, Vorobyov IV, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the hERG Channel in an Inactivated State and Associated Drug Interactions Biophysical Journal. 120: 243a. DOI: 10.1016/j.bpj.2020.11.1595  0.349
2020 Fletcher-Taylor S, Thapa P, Sepela RJ, Kaakati R, Yarov-Yarovoy V, Sack JT, Cohen BE. Distinguishing Potassium Channel Resting State Conformations in Live Cells with Environment-Sensitive Fluorescence. Acs Chemical Neuroscience. PMID 32579336 DOI: 10.1021/Acschemneuro.0C00276  0.8
2020 Thapa P, Fletcher-Taylor S, Sepela RJ, Yarov-Yarovoy V, Sack JT, Cohen BE. Observation of Multiple Potassium Channel Closed State Structures by Voltage Clamp Spectroscopy Biophysical Journal. 118: 262a. DOI: 10.1016/J.Bpj.2019.11.1520  0.785
2020 Marquis MJ, Nguyen M, Sack JT. Inhibition of the Voltage-Gated Potassium Channel KV2.1 by RY785, a Kv2-Selective Small Molecule Biophysical Journal. 118: 262a. DOI: 10.1016/j.bpj.2019.11.1519  0.493
2020 Maly J, Emigh AM, DeMarco K, Sack JT, Vorobyov IV, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the hERG Channel in an Inactivated State and Associated Drug Interactions Biophysical Journal. 118: 212a. DOI: 10.1016/J.Bpj.2019.11.1265  0.349
2019 Furutani K, Tsumoto K, Chen IS, Handa K, Yamakawa Y, Sack JT, Kurachi Y. Facilitation of current by some hERG channel blockers suppresses early afterdepolarizations. The Journal of General Physiology. PMID 30674563 DOI: 10.1085/jgp.201812192  0.371
2019 Islas LD, Miller C, Sack JT. Decision letter: Trans-toxin ion-sensitivity of charybdotoxin-blocked potassium-channels reveals unbinding transitional states Elife. DOI: 10.7554/Elife.46170.017  0.383
2019 Maly J, Emigh AM, DeMarco KR, Sack JT, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the HERG Channel in an Inactivated State and its Drug Interactions Biophysical Journal. 116: 104a. DOI: 10.1016/j.bpj.2018.11.598  0.357
2019 Marquis MJ, Sepela RJ, Sack JT. Decoupling between Voltage Sensor Movement and Pore Opening of Kv2.1 Channels Biophysical Journal. 116: 543a. DOI: 10.1016/J.BPJ.2018.11.2918  0.781
2019 Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov IV, Yarov-Yarovoy V. Structural Modeling of Drug Interactions with hERG Channel in Open and Closed States Biophysical Journal. 116: 249a-250a. DOI: 10.1016/J.Bpj.2018.11.1363  0.363
2018 Tilley DC, Angueyra JM, Eum KS, Kim H, Chao LH, Peng AW, Sack JT. The tarantula toxin GxTx detains K channel gating charges in their resting conformation. The Journal of General Physiology. PMID 30397012 DOI: 10.1085/Jgp.201812213  0.529
2018 Kirmiz M, Palacio S, Thapa P, King AN, Sack JT, Trimmer JS. Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Molecular Biology of the Cell. mbcE18050337. PMID 30091655 DOI: 10.1091/mbc.E18-05-0337  0.339
2018 Sepela RJ, Sack JT. Taming unruly chloride channel inhibitors with rational design. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735705 DOI: 10.1073/pnas.1805589115  0.761
2018 Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich R, Andersen OS, Sack JT. Synthetic analogs of the snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT) reveal that lipid bilayer perturbation does not underlie its modulation of voltage-gated potassium channels. Biochemistry. PMID 29616558 DOI: 10.1021/Acs.Biochem.8B00292  0.646
2018 Kimball IH, Nguyen PT, Sack JT, Yarov-Yarovoy V. Assessing the Structural Basis of μ-Conotoxin KIIIA Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.3431  0.507
2018 Emigh AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural Modeling of hERG Channel Interactions with Drugs using Rosetta Biophysical Journal. 114: 486a. DOI: 10.1016/J.Bpj.2017.11.2667  0.349
2018 Thapa P, Sepela R, Stewart R, Lillya M, Vivas O, Parajuli L, Fletcher-Taylor S, Zito K, Cohen BE, Sack J. Imaging Voltage Gating of Endogenous Neuronal Ion Channels with Fluorescent Tarantula Toxin Biophysical Journal. 114: 478a-479a. DOI: 10.1016/J.Bpj.2017.11.2631  0.775
2018 Fletcher-Taylor S, Thapa P, Sack JT, Cohen BE. Observation of Structural Changes in Closed K+ Channels by Voltage Clamp Spectroscopy Biophysical Journal. 114: 475a. DOI: 10.1016/J.Bpj.2017.11.2613  0.47
2018 Furutani K, Tsumoto K, Sack JT, Kurachi Y. Facilitation by hERG Channel Blockers Suppresses Early Afterdepolarization of Simulated Cardiac Action Potentials Biophysical Journal. 114: 474a. DOI: 10.1016/J.BPJ.2017.11.2607  0.346
2017 Sepela RJ, Sherlock BE, Tian L, Marcu L, Sack J. A strategy to measure electrophysiological changes with photoacoustic imaging (Conference Presentation) Proceedings of Spie. 10064. DOI: 10.1117/12.2251050  0.752
2017 Tilley DC, Eum KS, Sack JT. The Tarantula Toxin Guangxitoxin-1E Traps K + Channel Voltage Sensor in a Fully Resting Conformation Biophysical Journal. 112: 162a-163a. DOI: 10.1016/J.BPJ.2016.11.894  0.448
2017 Dockendorff C, Gandhi D, Kimball I, Eum KS, Rusinova R, Ingólfsson H, Kapoor R, Peyear T, Martin SF, Aldrich RW, Andersen OS, Sack J. Lipid Bilayer Perturbation by the Snail Toxin 6-Bromo-2-Mercaptotryptamine Dimer does not Account for its Modulation of Voltage-Gated Potassium Channels Biophysical Journal. 112: 246a-247a. DOI: 10.1016/J.Bpj.2016.11.1348  0.714
2017 Fletcher-Taylor S, Lillya MW, Thapa P, Cohen BE, Sack JT. Polarity of the Chemical Environment Surrounding Potassium Channel Voltage Sensors Detected by Solvatochromic Dye-Tarantula Toxin Conjugates Biophysical Journal. 112: 246a. DOI: 10.1016/J.Bpj.2016.11.1346  0.454
2017 Kimball IH, Nguyen PT, Yam J, Pressly B, York R, Sack JT, Yarov-Yarovoy V. Tarantula Toxin SGTx-1 alters Gating Kinetics of Human Voltage-Gated Sodium Channel Nav1.7 Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1316  0.526
2016 Tilley DC, Fleishman S, Sack JT, Yarov-Yarovoy V. What Determines the Charybdotoxin Specificity Among Kv1 Potassium Channels? Biophysical Journal. 110: 106a-107a. DOI: 10.1016/J.Bpj.2015.11.631  0.453
2016 Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Exploring Structural Interactions of Tarantula Toxins with Lipid Membranes using Rosetta and Molecular Dynamics Simulation Biophysical Journal. 110: 447a. DOI: 10.1016/J.Bpj.2015.11.2404  0.39
2016 Kimball IH, Nguyen PT, Sack JT, Yarov-Yarovoy V. Mapping the Nav1.7 Channel Interaction with the Conotoxin KIIIA Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2358  0.473
2016 Lillya MW, Parajuli LK, Fletcher-Taylor S, Huang J, Cohen BE, Zito K, Sack JT. Optical Recording of Voltage Activation of Endogenous Potassium Channels Biophysical Journal. 110: 344a. DOI: 10.1016/J.Bpj.2015.11.1853  0.534
2015 Thiffault I, Speca DJ, Austin DC, Cobb MM, Eum KS, Safina NP, Grote L, Farrow EG, Miller N, Soden S, Kingsmore SF, Trimmer JS, Saunders CJ, Sack JT. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization. The Journal of General Physiology. 146: 399-410. PMID 26503721 DOI: 10.1085/jgp.201511444  0.435
2015 Sack JT, Tilley DC. What keeps Kv channels small? The molecular physiology of modesty. The Journal of General Physiology. 146: 123-7. PMID 26216857 DOI: 10.1085/jgp.201511469  0.466
2015 Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Vladimir YY, Kim JI, Swartz KJ. Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels. Elife. 4: e06774. PMID 25948544 DOI: 10.7554/Elife.06774  0.377
2015 Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, et al. Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology. 593: 1347-60. PMID 25772290 DOI: 10.1113/Jphysiol.2014.281428  0.649
2015 Gupta K, Zamanian M, Bae C, Milescu M, Krepkiy D, Tilley DC, Sack JT, Yarov-Yarovoy V, Kim JI, Swartz KJ. Author response: Tarantula toxins use common surfaces for interacting with Kv and ASIC ion channels Elife. DOI: 10.7554/Elife.06774.017  0.361
2015 Sack JT, Tilley DC. What keeps Kv channels small? The molecular physiology of modesty Journal of General Physiology. 146: 123-127. DOI: 10.1085/jgp.201511469  0.466
2015 Nguyen PT, Kimball IH, Eum KS, Cohen BE, Sack JT, Yarov-Yarovoy V. Understanding the State Dependence of Voltage Sensor Toxin Action on Voltage Gated Sodium Channels Biophysical Journal. 108: 574a. DOI: 10.1016/J.Bpj.2014.11.3139  0.492
2014 Tilley DC, Eum KS, Fletcher-Taylor S, Austin DC, Dupré C, Patrón LA, Garcia RL, Lam K, Yarov-Yarovoy V, Cohen BE, Sack JT. Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E4789-96. PMID 25331865 DOI: 10.1073/Pnas.1406876111  0.54
2014 Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Structural Modeling of Toxin Interactions with the Human Voltage-Gated Sodium Channel Pore Biophysical Journal. 106: 130a. DOI: 10.1016/J.Bpj.2013.11.768  0.476
2014 Eum KS, Fletcher-Taylor S, Austin D, Cohen BE, Sack JT. Tethering Dimers of Voltage Sensor Toxins can Selectively Amplify their Affinity for Kv Channels Biophysical Journal. 106: 89a-90a. DOI: 10.1016/J.Bpj.2013.11.568  0.475
2014 Zamanian M, Bae C, Tilley D, Gupta K, Sack J, Yarov-Yarovoy V, Kim JI, Swartz K. Common Interaction Surfaces for Tarantula Toxins Targeting Kv and ASIC Channels Biophysical Journal. 106: 737-738. DOI: 10.1016/J.Bpj.2013.11.4065  0.543
2014 Tilley DC, Kaakati R, Yarov-Yarovoy V, Sack JT. Rosetta Structural Modeling of Tarantula Toxin Binding to Voltage Sensors Biophysical Journal. 106: 737a. DOI: 10.1016/J.Bpj.2013.11.4064  0.399
2013 Sack JT, Stephanopoulos N, Austin DC, Francis MB, Trimmer JS. Antibody-guided photoablation of voltage-gated potassium currents. The Journal of General Physiology. 142: 315-24. PMID 23940262 DOI: 10.1085/Jgp.201311023  0.477
2013 Nguyen PT, Sack JT, Allen TW, Yarov-Yarovoy V. Structural Modeling of the Human Nav1.7 Sodium Channel Pore Biophysical Journal. 104: 137a. DOI: 10.1016/J.Bpj.2012.11.783  0.455
2013 Ingólfsson HI, Thakur P, Herold KF, Maretzky T, Hall K, Zwama M, Yilmaz D, Hemmings HC, Blobel C, Koçer A, Sack J, Andersen OS. Phytochemicals Promiscuously Alter Membrane Protein Function and Bilayer Properties Biophysical Journal. 104: 93a. DOI: 10.1016/J.Bpj.2012.11.557  0.414
2013 Tilley DC, Eum KS, Cohen BE, Yarov-Yarovoy V, Sack JT. Fluorescently Labeled Tarantula Toxin Reveals Voltage Dependent Adhesion to K+ Channels Biophysical Journal. 104: 197a. DOI: 10.1016/J.Bpj.2012.11.1111  0.58
2012 Eum KS, Angueyra JM, Kim H, Chao L, Cohen BE, Sack JT. Allosteric Stabilization of Fully Resting Voltage Sensors by a Tarantula Toxin Biophysical Journal. 102: 531a. DOI: 10.1016/J.Bpj.2011.11.2903  0.508
2011 Mandikian D, Cerda O, Sack JT, Trimmer JS. A SUMO-Phospho tag team for wrestling with potassium channel gating. The Journal of General Physiology. 137: 435-9. PMID 21518832 DOI: 10.1085/Jgp.201110648  0.532
2010 Al-Sabi A, Shamotienko O, Dhochartaigh SN, Muniyappa N, Le Berre M, Shaban H, Wang J, Sack JT, Dolly JO. Arrangement of Kv1 alpha subunits dictates sensitivity to tetraethylammonium. The Journal of General Physiology. 136: 273-82. PMID 20805574 DOI: 10.1085/Jgp.200910398  0.414
2010 Sack JT, Stephanopoulos N, Trimmer JS. Arming Antibodies for Subtype-Selective Photo-Inhibition of Voltage Gated Potassium Channels Biophysical Journal. 98: 318a. DOI: 10.1016/j.bpj.2009.12.1725  0.364
2008 Sack JT, Shamotienko O, Dolly JO. How to validate a heteromeric ion channel drug target: assessing proper expression of concatenated subunits. The Journal of General Physiology. 131: 415-20. PMID 18411330 DOI: 10.1085/jgp.200709939  0.323
2007 Sokolov MV, Shamotienko O, Dhochartaigh SN, Sack JT, Dolly JO. Concatemers of brain Kv1 channel alpha subunits that give similar K+ currents yield pharmacologically distinguishable heteromers. Neuropharmacology. 53: 272-82. PMID 17637465 DOI: 10.1016/j.neuropharm.2007.05.008  0.447
2006 Sack JT, Aldrich RW. Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway. The Journal of General Physiology. 128: 119-32. PMID 16801385 DOI: 10.1085/jgp.200609492  0.703
2004 Sack JT, Aldrich RW, Gilly WF. A gastropod toxin selectively slows early transitions in the Shaker K channel's activation pathway. The Journal of General Physiology. 123: 685-96. PMID 15148327 DOI: 10.1085/jgp.200409047  0.717
2003 Kelley WP, Wolters AM, Sack JT, Jockusch RA, Jurchen JC, Williams ER, Sweedler JV, Gilly WF. Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity. The Journal of Biological Chemistry. 278: 34934-42. PMID 12815055 DOI: 10.1074/Jbc.M301271200  0.417
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