| Year |
Citation |
Score |
| 2019 |
Lengauer C. Cancer biology. Current Opinion in Oncology. 13: 57. PMID 11148687 DOI: 10.1097/00001622-200101000-00011 |
0.427 |
|
| 2018 |
Subbiah V, Gainor JF, Rahal R, Brubaker JD, Kim JL, Maynard M, Hu W, Cao Q, Sheets MP, Wilson D, Wilson KJ, DiPietro L, Fleming P, Palmer M, Hu MI, ... ... Lengauer C, et al. Precision Targeted Therapy With BLU-667 for RET-Driven Cancers. Cancer Discovery. PMID 29657135 DOI: 10.1158/2159-8290.Cd-18-0338 |
0.332 |
|
| 2015 |
Foo J, Liu LL, Leder K, Riester M, Iwasa Y, Lengauer C, Michor F. An Evolutionary Approach for Identifying Driver Mutations in Colorectal Cancer. Plos Computational Biology. 11: e1004350. PMID 26379039 DOI: 10.1371/Journal.Pcbi.1004350 |
0.436 |
|
| 2014 |
Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C. The landscape of kinase fusions in cancer. Nature Communications. 5: 4846. PMID 25204415 DOI: 10.1038/ncomms5846 |
0.435 |
|
| 2012 |
Liu H, Zilberstein A, Pannier P, Fleche F, Arendt C, Lengauer C, Hahn CS. Evaluating translocation gene fusions by SNP array data. Cancer Informatics. 11: 15-27. PMID 22259228 DOI: 10.4137/CIN.S8026 |
0.399 |
|
| 2009 |
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science (New York, N.Y.). 325: 1555-9. PMID 19661383 DOI: 10.1126/Science.1174229 |
0.728 |
|
| 2009 |
Wee S, Jagani Z, Xiang KX, Loo A, Dorsch M, Yao YM, Sellers WR, Lengauer C, Stegmeier F. PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers. Cancer Research. 69: 4286-93. PMID 19401449 DOI: 10.1158/0008-5472.Can-08-4765 |
0.311 |
|
| 2009 |
Wiederschain D, Wee S, Chen L, Loo A, Yang G, Huang A, Chen Y, Caponigro G, Yao YM, Lengauer C, Sellers WR, Benson JD. Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle (Georgetown, Tex.). 8: 498-504. PMID 19177017 DOI: 10.4161/Cc.8.3.7701 |
0.302 |
|
| 2008 |
Wee S, Wiederschain D, Maira SM, Loo A, Miller C, deBeaumont R, Stegmeier F, Yao YM, Lengauer C. PTEN-deficient cancers depend on PIK3CB. Proceedings of the National Academy of Sciences of the United States of America. 105: 13057-62. PMID 18755892 DOI: 10.1073/pnas.0802655105 |
0.402 |
|
| 2008 |
Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C, Hieter P. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 105: 3443-8. PMID 18299561 DOI: 10.1073/Pnas.0712384105 |
0.653 |
|
| 2007 |
Wiederschain D, Chen L, Johnson B, Bettano K, Jackson D, Taraszka J, Wang YK, Jones MD, Morrissey M, Deeds J, Mosher R, Fordjour P, Lengauer C, Benson JD. Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis Molecular and Cellular Biology. 27: 4968-4979. PMID 17452456 DOI: 10.1128/MCB.02244-06 |
0.349 |
|
| 2006 |
Gallmeier E, Calhoun ES, Rago C, Brody JR, Cunningham SC, Hucl T, Gorospe M, Kohli M, Lengauer C, Kern SE. Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options. Gastroenterology. 130: 2145-54. PMID 16762635 DOI: 10.1053/J.Gastro.2006.03.016 |
0.458 |
|
| 2005 |
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature. 436: 792. PMID 16094359 DOI: 10.1038/436792A |
0.469 |
|
| 2005 |
Michor F, Iwasa Y, Lengauer C, Nowak MA. Dynamics of colorectal cancer. Seminars in Cancer Biology. 15: 484-93. PMID 16055342 DOI: 10.1016/J.Semcancer.2005.06.005 |
0.57 |
|
| 2005 |
Samuels Y, Diaz LA, Schmidt-Kittler O, Cummins JM, Delong L, Cheong I, Rago C, Huso DL, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 7: 561-73. PMID 15950905 DOI: 10.1016/J.Ccr.2005.05.014 |
0.527 |
|
| 2005 |
Lengauer C, Diaz LA, Saha S. Cancer drug discovery through collaboration. Nature Reviews. Drug Discovery. 4: 375-80. PMID 15864266 DOI: 10.1038/Nrd1722 |
0.454 |
|
| 2005 |
Peters BA, Diaz LA, Polyak K, Meszler L, Romans K, Guinan EC, Antin JH, Myerson D, Hamilton SR, Vogelstein B, Kinzler KW, Lengauer C. Contribution of bone marrow-derived endothelial cells to human tumor vasculature Nature Medicine. 11: 261-262. PMID 15723071 DOI: 10.1038/Nm1200 |
0.36 |
|
| 2005 |
Michor F, Iwasa Y, Vogelstein B, Lengauer C, Nowak MA. Can chromosomal instability initiate tumorigenesis? Seminars in Cancer Biology. 15: 43-9. PMID 15613287 DOI: 10.1016/J.Semcancer.2004.09.007 |
0.569 |
|
| 2005 |
Lengauer C. Aneuploidy and genetic instability in cancer. Seminars in Cancer Biology. 15: 1. PMID 15613282 DOI: 10.1016/J.Semcancer.2004.09.001 |
0.529 |
|
| 2004 |
Spinette S, Lengauer C, Mahoney JA, Jallepalli PV, Wang Z, Casciola-Rosen L, Rosen A. Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation. Cell Cycle (Georgetown, Tex.). 3: 1638-44. PMID 15611659 DOI: 10.4161/Cc.3.12.1345 |
0.45 |
|
| 2004 |
Rajagopalan H, Lengauer C. Aneuploidy and cancer Nature. 432: 338-341. PMID 15549096 DOI: 10.1038/Nature03099 |
0.799 |
|
| 2004 |
Lengauer C, Wang Z. From spindle checkpoint to cancer. Nature Genetics. 36: 1144-5. PMID 15514664 DOI: 10.1038/Ng1104-1144 |
0.593 |
|
| 2004 |
Rajagopalan H, Lengauer C. CIN-ful cancers Cancer Chemotherapy and Pharmacology. 54: S65-S68. PMID 15309517 DOI: 10.1007/S00280-004-0889-8 |
0.793 |
|
| 2004 |
Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, ... ... Lengauer C, et al. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Research. 64: 2998-3001. PMID 15126332 DOI: 10.1158/0008-5472.Can-04-0587 |
0.639 |
|
| 2004 |
Rajagopalan H, Lengauer C. hCDC4 and genetic instability in cancer Cell Cycle. 3: 693-694. PMID 15118416 DOI: 10.4161/Cc.3.6.940 |
0.783 |
|
| 2004 |
Rajagopalan H, Jallepalli PV, Rago C, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C. Inactivation of hCDC4 can cause chromosomal instability Nature. 428: 77-81. PMID 14999283 DOI: 10.1038/Nature02313 |
0.805 |
|
| 2004 |
Wang TL, Diaz LA, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih IM, Iacobuzio-Donahue C, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients Proceedings of the National Academy of Sciences of the United States of America. 101: 3089-3094. PMID 14970324 DOI: 10.1073/Pnas.0308716101 |
0.458 |
|
| 2004 |
Michor F, Iwasa Y, Rajagopalan H, Lengauer C, Nowak MA. Linear model of colon cancer initiation. Cell Cycle (Georgetown, Tex.). 3: 358-62. PMID 14726709 DOI: 10.4161/Cc.3.3.690 |
0.8 |
|
| 2004 |
Kohli M, Rago C, Lengauer C, Kinzler KW, Vogelstein B. Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses Nucleic Acids Research. 32: e3. PMID 14704360 DOI: 10.1093/Nar/Gnh009 |
0.417 |
|
| 2003 |
Traverso G, Bettegowda C, Kraus J, Speicher MR, Kinzler KW, Vogelstein B, Lengauer C. Hyper-Recombination and Genetic Instability in BLM-Deficient Epithelial Cells Cancer Research. 63: 8578-8581. PMID 14695165 |
0.587 |
|
| 2003 |
Bardelli A, Saha S, Sager JA, Romans KE, Xin B, Markowitz SD, Lengauer C, Velculescu VE, Kinzler KW, Vogelstein B. PRL-3 Expression in Metastatic Cancers Clinical Cancer Research. 9: 5607-5615. PMID 14654542 |
0.331 |
|
| 2003 |
Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C. The significance of unstable chromosomes in colorectal cancer Nature Reviews Cancer. 3: 695-701. PMID 12951588 DOI: 10.1038/Nrc1165 |
0.789 |
|
| 2003 |
Montgomery E, Wilentz RE, Argani P, Fisher C, Hruban RH, Kern SE, Lengauer C. Analysis of anaphase figures in routine histologic sections distinguishes chromosomally unstable from chromosomally stable malignancies. Cancer Biology & Therapy. 2: 248-52. PMID 12878857 DOI: 10.4161/Cbt.2.3.362 |
0.53 |
|
| 2003 |
Lengauer C. Cancer. An unstable liaison. Science (New York, N.Y.). 300: 442-3. PMID 12702865 DOI: 10.1126/Science.1084468 |
0.467 |
|
| 2003 |
Jallepalli PV, Lengauer C, Vogelstein B, Bunz F. The Chk2 tumor suppressor is not required for p53 responses in human cancer cells. The Journal of Biological Chemistry. 278: 20475-9. PMID 12654917 DOI: 10.1074/Jbc.M213159200 |
0.318 |
|
| 2002 |
Komarova NL, Lengauer C, Vogelstein B, Nowak MA. Dynamics of genetic instability in sporadic and familial colorectal cancer. Cancer Biology & Therapy. 1: 685-92. PMID 12642695 DOI: 10.4161/Cbt.321 |
0.565 |
|
| 2002 |
Wang TL, Maierhofer C, Speicher MR, Lengauer C, Vogelstein B, Kinzler KW, Velculescu VE. Digital karyotyping. Proceedings of the National Academy of Sciences of the United States of America. 99: 16156-61. PMID 12461184 DOI: 10.1073/Pnas.202610899 |
0.361 |
|
| 2002 |
Nowak MA, Komarova NL, Sengupta A, Jallepalli PV, Shih IeM, Vogelstein B, Lengauer C. The role of chromosomal instability in tumor initiation. Proceedings of the National Academy of Sciences of the United States of America. 99: 16226-31. PMID 12446840 DOI: 10.1073/Pnas.202617399 |
0.642 |
|
| 2002 |
Teixeira da Costa L, Lengauer C. Exploring and exploiting instability. Cancer Biology & Therapy. 1: 212-25. PMID 12432267 |
0.464 |
|
| 2002 |
Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogelstein B, Velculescu VE. RAF/RAS oncogenes and mismatch-repair status Nature. 418: 934. PMID 12198537 DOI: 10.1038/418934A |
0.748 |
|
| 2002 |
Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 416: 552-6. PMID 11932749 DOI: 10.1038/416552A |
0.476 |
|
| 2002 |
Jallepalli PV, Lengauer C. Chromosome segregation and cancer: cutting through the mystery. Nature Reviews. Cancer. 1: 109-17. PMID 11905802 DOI: 10.1038/35101065 |
0.599 |
|
| 2001 |
Lengauer C. How do tumors make ends meet? Proceedings of the National Academy of Sciences of the United States of America. 98: 12331-3. PMID 11675484 DOI: 10.1073/Pnas.231485898 |
0.477 |
|
| 2001 |
Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B. A phosphatase associated with metastasis of colorectal cancer. Science (New York, N.Y.). 294: 1343-6. PMID 11598267 DOI: 10.1126/Science.1065817 |
0.55 |
|
| 2001 |
Caballero OL, Cohen D, Liu Q, Esteller M, Bonacum J, White P, Engles J, Yochem R, Herman JG, Westra WH, Lengauer C, Sidransky D, Jen J. Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer. Genes, Chromosomes & Cancer. 32: 119-25. PMID 11550279 DOI: 10.1002/Gcc.1173 |
0.428 |
|
| 2001 |
Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C. Securin is required for chromosomal stability in human cells. Cell. 105: 445-57. PMID 11371342 DOI: 10.1016/S0092-8674(01)00340-3 |
0.472 |
|
| 2001 |
Bardelli A, Cahill DP, Lederer G, Speicher MR, Kinzler KW, Vogelstein B, Lengauer C. Carcinogen-specific induction of genetic instability. Proceedings of the National Academy of Sciences of the United States of America. 98: 5770-5. PMID 11296254 DOI: 10.1073/Pnas.081082898 |
0.426 |
|
| 2001 |
Thiagalingam S, Laken S, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B, Lengauer C. Mechanisms underlying losses of heterozygosity in human colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 98: 2698-702. PMID 11226302 DOI: 10.1073/Pnas.051625398 |
0.561 |
|
| 2000 |
Krasner A, Wallace L, Thiagalingam A, Jones C, Lengauer C, Minahan L, Ma Y, Kalikin L, Feinberg AP, Jabs EW, Tunnacliffe A, Baylin SB, Ball DW, Nelkin BD. Cloning and chromosomal localization of the human BARX2 homeobox protein gene. Gene. 250: 171-80. PMID 10854790 DOI: 10.1016/S0378-1119(00)00169-4 |
0.422 |
|
| 2000 |
Rhee I, Jair KW, Yen RW, Lengauer C, Herman JG, Kinzler KW, Vogelstein B, Baylin SB, Schuebel KE. CpG methylation is maintained in human cancer cells lacking DNMT1. Nature. 404: 1003-7. PMID 10801130 DOI: 10.1038/35010000 |
0.4 |
|
| 1999 |
Cahill DP, Kinzler KW, Vogelstein B, Lengauer C. Genetic instability and darwinian selection in tumours. Trends in Cell Biology. 9: M57-60. PMID 10611684 DOI: 10.1016/S0168-9525(99)01874-0 |
0.504 |
|
| 1999 |
Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature. 401: 616-20. PMID 10524633 DOI: 10.1038/44188 |
0.41 |
|
| 1999 |
Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, Williams J, Lengauer C, Kinzler KW, Vogelstein B. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. The Journal of Clinical Investigation. 104: 263-9. PMID 10430607 DOI: 10.1172/Jci6863 |
0.419 |
|
| 1999 |
Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics. 58: 181-7. PMID 10366450 DOI: 10.1006/Geno.1999.5831 |
0.532 |
|
| 1999 |
Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature. 396: 643-9. PMID 9872311 DOI: 10.1038/25292 |
0.588 |
|
| 1998 |
Polyak K, Li Y, Zhu H, Lengauer C, Willson JK, Markowitz SD, Trush MA, Kinzler KW, Vogelstein B. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nature Genetics. 20: 291-3. PMID 9806551 DOI: 10.1038/3108 |
0.496 |
|
| 1998 |
Hermeking H, Lengauer C, Polyak K, He TC, Zhang L, Thiagalingam S, Kinzler KW, Vogelstein B. 14-3-3sigma is a p53-regulated inhibitor of G2/M progression. Molecular Cell. 1: 3-11. PMID 9659898 DOI: 10.1016/S1097-2765(00)80002-7 |
0.355 |
|
| 1998 |
Lengauer C, Issa JP. The role of epigenetics in cancer Molecular Medicine Today. 4: 102-103. PMID 9575489 DOI: 10.1016/S1357-4310(98)01220-9 |
0.414 |
|
| 1998 |
Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature. 392: 300-3. PMID 9521327 DOI: 10.1038/32688 |
0.677 |
|
| 1998 |
Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD. RREB1, a ras responsive element binding protein, maps to human chromosome 6p25. Genomics. 45: 630-2. PMID 9367691 DOI: 10.1006/Geno.1997.5001 |
0.346 |
|
| 1997 |
Lengauer C, Kinzler KW, Vogelstein B. DNA methylation and genetic instability in colorectal cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 2545-50. PMID 9122232 DOI: 10.1073/Pnas.94.6.2545 |
0.491 |
|
| 1997 |
Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 386: 623-7. PMID 9121588 DOI: 10.1038/386623A0 |
0.593 |
|
| 1996 |
Pietenpol JA, Lengauer C, Jordan J, Kinzler KW, Vogelstein B. Mammalian cells resistant to tumor suppressor genes Proceedings of the National Academy of Sciences of the United States of America. 93: 8390-8394. PMID 8710881 DOI: 10.1073/Pnas.93.16.8390 |
0.33 |
|
| 1996 |
Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JK, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nature Genetics. 13: 343-6. PMID 8673134 DOI: 10.1038/Ng0796-343 |
0.596 |
|
| 1996 |
Waldman T, Lengauer C, Kinzler KW, Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature. 381: 713-6. PMID 8649519 DOI: 10.1038/381713A0 |
0.347 |
|
| 1995 |
Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, D'Arrigo A, Markowitz S, Willson JK, Kinzler KW. Mutations of GTBP in genetically unstable cells. Science (New York, N.Y.). 268: 1915-7. PMID 7604266 DOI: 10.1126/Science.7604266 |
0.496 |
|
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