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Charis Eng - Publications

Affiliations: 
Ohio State University, Columbus, Columbus, OH 
Area:
Genetics, Molecular Biology
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Year Citation  Score
2023 Kang SC, Sarn NB, Venegas J, Tan Z, Hitomi M, Eng C. Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids. Molecular Psychiatry. PMID 38030818 DOI: 10.1038/s41380-023-02325-3  0.326
2023 Dhawan A, Eng C. Is the gene mutation associated with thrombosis? Cleveland Clinic Journal of Medicine. 90: 661-663. PMID 37914198 DOI: 10.3949/ccjm.90a.23044  0.329
2023 Hitomi M, Venegas J, Kang SC, Eng C. Differential cell cycle checkpoint evasion by PTEN germline mutations associated with dichotomous phenotypes of cancer versus autism spectrum disorder. Oncogene. PMID 37907589 DOI: 10.1038/s41388-023-02867-4  0.36
2023 Xiong D, Zhao J, Qiu Y, Zhou Y, Lee D, Gupta S, Lu W, Liang S, Kang JJ, Eng C, Loscalzo J, Cheng F, Yu H. 3D structural human interactome reveals proteome-wide perturbations by disease mutations. Biorxiv : the Preprint Server For Biology. PMID 37162909 DOI: 10.1101/2023.04.24.538110  0.312
2023 Miller KM, Sbeih F, Contrera K, Reddy CA, Marquard J, Eng C, Lorenz RR. Reduced Risk of Corporal Tumors in Patients With Head and Neck Paragangliomas With p.Pro81Leu Mutations. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. PMID 36939592 DOI: 10.1002/ohn.274  0.341
2023 Smith IN, Dawson JE, Eng C. Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in -Associated Mutations in Autism and Cancer. The Journal of Physical Chemistry. B. PMID 36626331 DOI: 10.1021/acs.jpcb.2c06776  0.307
2022 Chen JL, Miller DT, Schmidt LS, Malkin D, Korf BR, Eng C, Kwiatkowski DJ, Giannikou K. Mosaicism in Tumor Suppressor Gene Syndromes: Prevalence, Diagnostic Strategies, and Transmission Risk. Annual Review of Genomics and Human Genetics. 23: 331-361. PMID 36044908 DOI: 10.1146/annurev-genom-120121-105450  0.317
2022 Brewer T, Yehia L, Bazeley P, Eng C. Exome sequencing reveals a distinct somatic genomic landscape in breast cancer from women with germline PTEN variants. American Journal of Human Genetics. 109: 1520-1533. PMID 35931053 DOI: 10.1016/j.ajhg.2022.07.005  0.307
2020 Ramkumar RR, Murthy PB, Nguyen JK, McKenney J, Eng C, Campbell SC. PTEN Hamartoma Tumor Syndrome: A Case of Renal Cell Carcinoma in a Young Female. Urology. PMID 33227300 DOI: 10.1016/j.urology.2020.11.024  0.317
2020 Kotsopoulos J, Gronwald J, McCuaig JM, Karlan BY, Eisen A, Tung N, Bordeleau L, Senter L, Eng C, Couch F, Fruscio R, Weitzel JN, Olopade O, Singer CF, Pal T, et al. Breastfeeding and the risk of epithelial ovarian cancer among women with a BRCA1 or BRCA2 mutation. Gynecologic Oncology. PMID 33010967 DOI: 10.1016/j.ygyno.2020.09.037  0.306
2020 Abbas A, Padmanabhan R, Eng C. Metabolic stress regulates genome-wide transcription in a PTEN-dependent manner. Human Molecular Genetics. PMID 32744308 DOI: 10.1093/Hmg/Ddaa168  0.305
2020 Jaini R, Loya MG, King AT, Thacker S, Sarn NB, Yu Q, Stark GR, Eng C. Germline PTEN mutations are associated with a skewed peripheral immune repertoire in humans and mice. Human Molecular Genetics. PMID 32588888 DOI: 10.1093/Hmg/Ddaa118  0.445
2020 Yehia L, Eng C. PTEN hamartoma tumour syndrome: What happens when there is no PTEN germline mutation? Human Molecular Genetics. PMID 32568377 DOI: 10.1093/Hmg/Ddaa127  0.468
2020 Kang SC, Jaini R, Hitomi M, Lee H, Sarn N, Thacker S, Eng C. Decreased nuclear Pten in neural stem cells contributes to deficits in neuronal maturation. Molecular Autism. 11: 43. PMID 32487265 DOI: 10.1186/S13229-020-00337-2  0.353
2020 Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP. WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. The New England Journal of Medicine. 382: 2103-2116. PMID 32459922 DOI: 10.1056/Nejmoa1914919  0.513
2020 Mighell TL, Thacker S, Fombonne E, Eng C, O'Roak BJ. An Integrated Deep-Mutational-Scanning Approach Provides Clinical Insights on PTEN Genotype-Phenotype Relationships. American Journal of Human Genetics. PMID 32442409 DOI: 10.1016/J.Ajhg.2020.04.014  0.371
2020 Larsen LV, Mirebeau-Prunier D, Imai T, Alvarez-Escola C, Hasse-Lazar K, Censi S, Castroneves LA, Sakurai A, Kihara M, Horiuchi K, Barbu VD, Borson-Chazot F, Gimenez-Roqueplo AP, Pigny P, Pinson S, ... ... Eng C, et al. Primary hyperparathyroidism as first manifestation in MEN 2A: an international multicenter study. Endocrine Connections. PMID 32375120 DOI: 10.1530/Ec-20-0163  0.304
2020 Akhavanfard S, Padmanabhan R, Yehia L, Cheng F, Eng C. Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors. Nature Communications. 11: 2206. PMID 32371905 DOI: 10.1038/S41467-020-16067-1  0.358
2020 Sheehan M, Heald B, Yanda C, Kelly ED, Grobmyer S, Eng C, Kalady M, Pederson H. Investigating the Link between Lynch Syndrome and Breast Cancer. European Journal of Breast Health. 16: 106-109. PMID 32285031 DOI: 10.5152/Ejbh.2020.5198  0.352
2020 Liu C, Zhao J, Lu W, Dai Y, Hockings J, Zhou Y, Nussinov R, Eng C, Cheng F. Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes. Plos Computational Biology. 16: e1007701. PMID 32101536 DOI: 10.1371/Journal.Pcbi.1007701  0.42
2020 Sarn N, Jaini R, Thacker S, Lee H, Dutta R, Eng C. Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype. Molecular Psychiatry. PMID 32055008 DOI: 10.1038/S41380-020-0681-0  0.303
2020 Yehia L, Seyfi M, Niestroj LM, Padmanabhan R, Ni Y, Frazier TW, Lal D, Eng C. Copy Number Variation and Clinical Outcomes in Patients With Germline PTEN Mutations. Jama Network Open. 3: e1920415. PMID 32003824 DOI: 10.1001/jamanetworkopen.2019.20415  0.316
2019 Kotsopoulos J, Gronwald J, Lubinski J, McCuaig J, Lynch HT, Neuhausen SL, Foulkes WD, Weitzel JN, Senter L, Tung N, Eng C, Karlan B, Sun P, Narod SA. Does preventive oophorectomy increase the risk of depression in BRCA mutation carriers? Menopause (New York, N.Y.). PMID 31644510 DOI: 10.1097/Gme.0000000000001437  0.391
2019 Busch RM, Srivastava S, Hogue O, Frazier TW, Klaas P, Hardan A, Martinez-Agosto JA, Sahin M, Eng C. Neurobehavioral phenotype of autism spectrum disorder associated with germline heterozygous mutations in PTEN. Translational Psychiatry. 9: 253. PMID 31594918 DOI: 10.1038/S41398-019-0588-1  0.346
2019 Ngeow J, Eng C. PTEN in Hereditary and Sporadic Cancer. Cold Spring Harbor Perspectives in Medicine. PMID 31570378 DOI: 10.1101/Cshperspect.A036087  0.406
2019 Yehia L, Ni Y, Feng F, Seyfi M, Sadler T, Frazier TW, Eng C. Distinct Alterations in Tricarboxylic Acid Cycle Metabolites Associate with Cancer and Autism Phenotypes in Cowden Syndrome and Bannayan-Riley-Ruvalcaba Syndrome. American Journal of Human Genetics. PMID 31564436 DOI: 10.1016/J.Ajhg.2019.09.004  0.408
2019 Yehia L, Keel E, Eng C. The Clinical Spectrum of Mutations. Annual Review of Medicine. PMID 31433956 DOI: 10.1146/Annurev-Med-052218-125823  0.494
2019 Chong ST, Tan KM, Kok CYL, Guan SP, Lai SH, Lim C, Hu J, Sturgis C, Eng C, Lam PYP, Ngeow J. IL13RA2 is differentially regulated in Papillary Thyroid Carcinoma versus Follicular Thyroid Carcinoma. The Journal of Clinical Endocrinology and Metabolism. PMID 31290966 DOI: 10.1210/Jc.2019-00040  0.333
2019 Smith IN, Thacker S, Seyfi M, Cheng F, Eng C. Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer. American Journal of Human Genetics. PMID 31006514 DOI: 10.1016/J.Ajhg.2019.03.009  0.422
2019 Metcalfe K, Eisen A, Senter L, Armel S, Bordeleau L, Meschino WS, Pal T, Lynch HT, Tung NM, Kwong A, Ainsworth P, Karlan B, Moller P, Eng C, Weitzel JN, et al. International trends in the uptake of cancer risk reduction strategies in women with a BRCA1 or BRCA2 mutation. British Journal of Cancer. PMID 30971774 DOI: 10.1038/S41416-019-0446-1  0.419
2019 Cheng F, Eng C. PTEN Mutations Trigger Resistance to Immunotherapy. Trends in Molecular Medicine. PMID 30928438 DOI: 10.1016/J.Molmed.2019.03.003  0.356
2019 Wanchai V, Jin J, Bircan E, Eng C, Orloff M. Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk. Bmc Bioinformatics. 20: 98. PMID 30871476 DOI: 10.1186/S12859-019-2622-Y  0.324
2019 Ngeow J, Eng C. PTEN mutations: help spot thyroid cancer before it occurs. Expert Review of Endocrinology & Metabolism. 7: 251-254. PMID 30780837 DOI: 10.1586/eem.12.15  0.341
2019 Lee H, Thacker S, Sarn N, Dutta R, Eng C. Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder. Translational Psychiatry. 9: 13. PMID 30664625 DOI: 10.1038/S41398-018-0364-7  0.305
2019 Castinetti F, Waguespack SG, Machens A, Uchino S, Lazaar K, Sanso G, Else T, Dvorakova S, Qi XP, Elisei R, Maia AL, Glod J, Lourenço DM, Valdes N, Mathiesen J, ... ... Eng C, et al. Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study. The Lancet. Diabetes & Endocrinology. PMID 30660595 DOI: 10.1016/S2213-8587(18)30336-X  0.359
2019 Yehia L, Ngeow J, Eng C. PTEN-opathies: from biological insights to evidence-based precision medicine. The Journal of Clinical Investigation. PMID 30614812 DOI: 10.1172/Jci121277  0.441
2019 Cheng F, Liang H, Butte AJ, Eng C, Nussinov R. Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health. Pharmacological Reviews. 71: 1-19. PMID 30545954 DOI: 10.1124/Pr.118.016253  0.316
2019 Khare A, Burke CA, Leach B, O'Malley M, LaGuardia L, Eng C, Mankaney G. 2894 The Gastrointestinal Phenotype of Cowden’s Syndrome and Effects of Surveillance The American Journal of Gastroenterology. 114. DOI: 10.14309/01.Ajg.0000601108.52032.50  0.327
2019 Akhavanfard S, Yehia L, Padmanabhan R, Romigh T, Ni Y, Eng C. Germline EGFR mutation and cancer predisposition in adolescent and young adult (AYA) females with adrenocortical carcinoma. Journal of Clinical Oncology. 37. DOI: 10.1200/Jco.2019.37.15_Suppl.E13014  0.395
2019 Pederson H, Heald B, Budd G, Bernhisel R, Cummings S, Saam J, Lancaster J, Grobmyer S, Eng C. Abstract P1-10-01: Defining the spectrum of germline variants among African American patients with triple negative breast cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P1-10-01  0.339
2019 Chong ST, Kok CY, Tan KM, Guan SP, Lai SH, Lim C, Hu J, Sturgis C, Eng C, Lam PY, Ngeow J. Abstract 2780: IL13RA2 is differentially regulated in papillary thyroid carcinoma versus follicular thyroid carcinoma Cancer Research. 79: 2780-2780. DOI: 10.1158/1538-7445.Am2019-2780  0.327
2018 Mester JL, Ghosh R, Pesaran T, Huether R, Karam R, Hruska KS, Costa HA, Lachlan K, Ngeow J, Barnholtz-Sloan J, Sesock K, Hernandez F, Zhang L, Milko L, Plon SE, ... ... Eng C, et al. Gene-specific criteria for PTEN variant curation: Recommendations from the ClinGen PTEN Expert Panel. Human Mutation. 39: 1581-1592. PMID 30311380 DOI: 10.1002/Humu.23636  0.329
2018 Feng F, Yehia L, Ni Y, Chang YS, Jhiang SM, Eng C. A non-pump function of sodium iodide symporter in thyroid cancer via crosstalk with PTEN signaling. Cancer Research. PMID 30217930 DOI: 10.1158/0008-5472.Can-18-1954  0.339
2018 Yehia L, Jindal S, Komar AA, Eng C. Non-Canonical Role of Cancer-Associated Mutant SEC23B in the Ribosome Biogenesis Pathway. Human Molecular Genetics. PMID 29893852 DOI: 10.1093/Hmg/Ddy226  0.349
2018 Neumann HPH, Young W, Krauss T, Bayley JP, Schiavi F, Opocher G, Boedeker C, Tirosh A, Castinetti F, Ruf J, Beltsevich D, Walz MK, Groeben H, Von Dobschuetz E, Gimm O, ... ... Eng C, et al. Genetics Informs Precision Practice in the Diagnosis and Management of Pheochromocytoma. Endocrine-Related Cancer. PMID 29794110 DOI: 10.1530/Erc-18-0085  0.419
2018 Yehia L, Eng C. One gene - many endocrine and metabolic syndromes: PTEN-opathies and precision medicine. Endocrine-Related Cancer. PMID 29792313 DOI: 10.1530/Erc-18-0162  0.498
2018 Kotsopoulos J, Gronwald J, Lynch HT, Eisen A, Neuhausen SL, Tung N, Ainsworth P, Weitzel JN, Pal T, Foulkes WD, Eng C, Singer CF, Senter L, Sun P, Lubinski J, et al. Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment. PMID 29774471 DOI: 10.1007/S10549-018-4822-Y  0.39
2018 Krauss T, Ferrara AM, Links TP, Wellner U, Bancos I, Kvachenyuk A, Villar Gómez de Las Heras K, Yukina M, Petrov R, Bullivant G, von Duecker L, Jadhav SS, Ploeckinger U, Welin S, Schalin-Jantti C, ... ... Eng C, et al. Preventive medicine for von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors. Endocrine-Related Cancer. PMID 29748190 DOI: 10.1530/Erc-18-0100  0.311
2018 Yehia L, Ni Y, Sesock K, Niazi F, Fletcher B, Chen HJ, LaFramboise T, Eng C. Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations. Plos Genetics. 14: e1007352. PMID 29684080 DOI: 10.1371/Journal.Pgen.1007352  0.491
2018 Smith IN, Thacker S, Jaini R, Eng C. Dynamics and Structural Stability Effects of Germline PTEN Mutations Associated with Cancer versus Autism Phenotypes. Journal of Biomolecular Structure & Dynamics. 1-44. PMID 29663862 DOI: 10.1080/07391102.2018.1465854  0.504
2018 Kim SJ, Huzarski T, Gronwald J, Singer CF, Møller P, Lynch HT, Armel S, Karlan BY, Foulkes WD, Neuhausen SL, Senter L, Eisen A, Eng C, Panchal S, Pal T, et al. Prospective evaluation of body size and breast cancer risk among BRCA1 and BRCA2 mutation carriers. International Journal of Epidemiology. PMID 29547931 DOI: 10.1093/Ije/Dyy039  0.371
2018 Lammert J, Lubinski J, Gronwald J, Huzarski T, Armel S, Eisen A, Meschino WS, Lynch HT, Snyder C, Eng C, Olopade OI, Ginsburg O, Foulkes WD, Elser C, Cohen SA, et al. Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment. PMID 29404807 DOI: 10.1007/S10549-018-4694-1  0.34
2018 Pederson HJ, Gopalakrishnan D, Noss R, Yanda C, Eng C, Grobmyer SR. Impact of Multigene Panel Testing on Surgical Decision Making in Breast Cancer Patients. Journal of the American College of Surgeons. PMID 29360614 DOI: 10.1016/J.Jamcollsurg.2017.12.037  0.385
2018 Nizialek E, Gopalakrishnan D, Yanda C, Abbas H, Kline M, Stephens M, Grobmyer S, Eng C, Mitchell A, Pederson H, Vinayak S. Abstract P4-06-04: Germline alterations in African-American versus Caucasian patients with triple-negative breast cancer in the era of multi-gene panel testing Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P4-06-04  0.339
2018 Smith IN, Thacker S, Eng C. Abstract 4283: A structure network approach to predict the dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes Cancer Research. 78: 4283-4283. DOI: 10.1158/1538-7445.Am2018-4283  0.484
2017 Yehia L, Ni Y, Eng C. Germline TTN variants are enriched in PTEN-wildtype Bannayan-Riley-Ruvalcaba syndrome. Npj Genomic Medicine. 2: 37. PMID 29263846 DOI: 10.1038/S41525-017-0039-Y  0.421
2017 Byrd V, Getz TM, Padmanabhan R, Arora H, Eng C. Microbiome in PTEN hamartoma tumor syndrome. Endocrine-Related Cancer. PMID 29233840 DOI: 10.1530/Erc-17-0442  0.425
2017 Mukherjee PK, Wang H, Retuerto M, Zhang H, Burkey B, Ghannoum MA, Eng C. Bacteriome and mycobiome associations in oral tongue cancer. Oncotarget. 8: 97273-97289. PMID 29228609 DOI: 10.18632/Oncotarget.21921  0.315
2017 Wang H, Altemus J, Niazi F, Green H, Calhoun BC, Sturgis C, Grobmyer SR, Eng C. Breast tissue, oral and urinary microbiomes in breast cancer. Oncotarget. 8: 88122-88138. PMID 29152146 DOI: 10.18632/Oncotarget.21490  0.311
2017 Hicks JK, Shealy A, Schreiber A, Coleridge M, Noss R, Natowicz M, Moran R, Moss T, Erwin A, Eng C. Patient Decisions to Receive Secondary Pharmacogenomic Findings and Development of a Multidisciplinary Practice Model to Integrate Results Into Patient Care. Clinical and Translational Science. PMID 28749586 DOI: 10.1111/Cts.12493  0.309
2017 Chen HJ, Romigh T, Sesock K, Eng C. Characterization of cryptic splicing in germline PTEN intronic variants in Cowden syndrome. Human Mutation. PMID 28677221 DOI: 10.1002/Humu.23288  0.455
2017 Castinetti F, Maia AL, Peczkowska M, Barontini M, Hasse-Lazar K, Links TP, Toledo RA, Dvorakova S, Mian C, Bugalho MJ, Zovato S, Alevizaki M, Kvachenyuk A, Bausch B, Loli P, ... ... Eng C, et al. THE PENETRANCE OF MEN2 PHEOCHROMOCYTOMA IS NOT ONLY DETERMINED BY RET MUTATIONS. Endocrine-Related Cancer. PMID 28649091 DOI: 10.1530/Erc-17-0189  0.448
2017 Hansen-Kiss E, Beinkampen S, Adler B, Frazier T, Prior T, Erdman S, Eng C, Herman G. A retrospective chart review of the features of PTEN hamartoma tumour syndrome in children. Journal of Medical Genetics. PMID 28526761 DOI: 10.1136/Jmedgenet-2016-104484  0.38
2017 Ngeow J, Sesock K, Eng C. Clinical Implications for Germline PTEN Spectrum Disorders. Endocrinology and Metabolism Clinics of North America. 46: 503-517. PMID 28476234 DOI: 10.1016/J.Ecl.2017.01.013  0.399
2017 Bausch B, Schiavi F, Ni Y, Welander J, Patocs A, Ngeow J, Wellner U, Malinoc A, Taschin E, Barbon G, Lanza V, Söderkvist P, Stenman A, Larsson C, Svahn F, ... ... Eng C, et al. Clinical Characterization of the Pheochromocytoma and Paraganglioma Susceptibility Genes SDHA, TMEM127, MAX, and SDHAF2 for Gene-Informed Prevention. Jama Oncology. PMID 28384794 DOI: 10.1001/Jamaoncol.2017.0223  0.409
2017 Yehia L, Ni Y, Eng C. Thyroglobulin in Metastatic Thyroid Cancer: Culprit or Red Herring? American Journal of Human Genetics. 100: 562-563. PMID 28257694 DOI: 10.1016/J.Ajhg.2017.01.023  0.321
2017 Arora HC, Eng C, Shoskes DA. Gut microbiome and chronic prostatitis/chronic pelvic pain syndrome. Annals of Translational Medicine. 5: 30. PMID 28217695 DOI: 10.21037/Atm.2016.12.32  0.301
2017 Wang H, Funchain P, Bebek G, Altemus J, Zhang H, Niazi F, Peterson C, Lee WT, Burkey BB, Eng C. Microbiomic differences in tumor and paired-normal tissue in head and neck squamous cell carcinomas. Genome Medicine. 9: 14. PMID 28173873 DOI: 10.1186/S13073-017-0405-5  0.311
2017 Yu W, Ni Y, Saji M, Ringel MD, Jaini R, Eng C. Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells. Human Molecular Genetics. PMID 28164237 DOI: 10.1093/Hmg/Ddx037  0.453
2017 Kotsopoulos J, Huzarski T, Gronwald J, Singer CF, Moller P, Lynch HT, Armel S, Karlan B, Foulkes WD, Neuhausen SL, Senter L, Tung N, Weitzel JN, Eisen A, Metcalfe K, ... Eng C, et al. Bilateral Oophorectomy and Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. Journal of the National Cancer Institute. 109. PMID 27601060 DOI: 10.1093/Jnci/Djw177  0.405
2016 Ngeow J, Eng C. Precision medicine in heritable cancer: when somatic tumour testing and germline mutations meet. Npj Genomic Medicine. 1: 15006. PMID 29263804 DOI: 10.1038/Npjgenmed.2015.6  0.444
2016 Ni Y, Seballos S, Fletcher B, Romigh T, Yehia L, Mester J, Senter L, Niazi F, Saji M, Ringel MD, LaFramboise T, Eng C. Germline Compound Heterozygous Poly-glutamine Deletion in USF3 May Be Involved in Predisposition to Heritable and Sporadic Epithelial Thyroid Carcinoma. Human Molecular Genetics. PMID 28011713 DOI: 10.1093/Hmg/Ddw382  0.428
2016 Colby S, Yehia L, Niazi F, Chen J, Ni Y, Mester JL, Eng C. Exome sequencing reveals germline gain-of-function EGFR mutation in an adult with Lhermitte-Duclos disease. Cold Spring Harbor Molecular Case Studies. 2: a001230. PMID 27900366 DOI: 10.1101/mcs.a001230  0.319
2016 Chen HH, Händel N, Ngeow J, Muller J, Hühn M, Yang HT, Heindl M, Berbers RM, Hegazy AN, Kionke J, Yehia L, Sack U, Bläser F, Rensing-Ehl A, Reifenberger J, ... ... Eng C, et al. Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells. The Journal of Allergy and Clinical Immunology. PMID 27477328 DOI: 10.1016/J.Jaci.2016.03.059  0.406
2016 Ngeow J, Eng C. Mismatch Repair Deficiency in Colorectal Cancers: Is Somatic Genomic Testing the Grab-Bag for All Answers? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 27161963 DOI: 10.1200/Jco.2016.66.7766  0.459
2016 Nielsen SM, Rhodes L, Blanco I, Chung WK, Eng C, Maher ER, Richard S, Giles RH. Von Hippel-Lindau Disease: Genetics and Role of Genetic Counseling in a Multiple Neoplasia Syndrome. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. PMID 27114602 DOI: 10.1200/Jco.2015.65.6140  0.462
2016 Ngeow J, Eng C. Germline PTEN Mutation Analysis for PTEN Hamartoma Tumor Syndrome. Methods in Molecular Biology (Clifton, N.J.). 1388: 63-73. PMID 27033071 DOI: 10.1007/978-1-4939-3299-3_6  0.518
2016 Ngeow J, Eng C. HABP2 in Familial Non-medullary Thyroid Cancer: Will the Real Mutation Please Stand Up? Journal of the National Cancer Institute. 108. PMID 26832774 DOI: 10.1093/Jnci/Djw013  0.437
2016 Kotsopoulos J, Huzarski T, Gronwald J, Moller P, Lynch HT, Neuhausen SL, Senter L, Demsky R, Foulkes WD, Eng C, Karlan B, Tung N, Singer CF, Sun P, Lubinski J, et al. Hormone replacement therapy after menopause and risk of breast cancer in BRCA1 mutation carriers: a case-control study. Breast Cancer Research and Treatment. PMID 26780555 DOI: 10.1007/S10549-016-3685-3  0.407
2016 Nizialek EA, Sankunny M, Niazi F, Eng C. Cancer-predisposition gene KLLN maintains pericentric H3K9 trimethylation protecting genomic stability. Nucleic Acids Research. 44: 3586-94. PMID 26673699 DOI: 10.1093/Nar/Gkv1481  0.325
2016 Sankunny M, Nizialek E, Niazi F, Eng C. Abstract 3596: KLLN protects genomic stability by maintaining H3K9 trimethylation (H3K9me3) at the pericentric heterochromatin Cancer Research. 76: 3596-3596. DOI: 10.1158/1538-7445.Am2016-3596  0.355
2016 Ikeda Y, Kiyotani K, Yew PY, Kato T, Tamura K, Yap KL, Mester JL, Nielsen SH, Raymon GH, Eng C, Nakamura Y. Abstract 3480: Germline PARP4 mutations in patients with primary thyroid and breast cancers Cancer Research. 76: 3480-3480. DOI: 10.1158/1538-7445.Am2016-3480  0.443
2016 Karagkounis G, Heald B, Liska D, Plesec T, Eng C, Church JM, Kalady MF. Clinical Implications of Microsatellite Instability in Rectal Cancer Journal of the American College of Surgeons. 223. DOI: 10.1016/J.Jamcollsurg.2016.06.073  0.307
2015 Ngeow J, Sesock K, Eng C. Breast cancer risk and clinical implications for germline PTEN mutation carriers. Breast Cancer Research and Treatment. PMID 26700035 DOI: 10.1007/S10549-015-3665-Z  0.489
2015 Ikeda Y, Kiyotani K, Yew PY, Kato T, Tamura K, Yap KL, Nielsen S, Mester J, Eng C, Nakamura Y, Grogan RH. Germline PARP4 mutations in patients with primary thyroid and breast cancers. Endocrine-Related Cancer. PMID 26699384 DOI: 10.1530/Erc-15-0359  0.448
2015 He X, Thacker S, Romigh T, Yu Q, Frazier TW, Eng C. Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits. Molecular Autism. 6: 63. PMID 26579216 DOI: 10.1186/S13229-015-0056-6  0.405
2015 Yehia L, Niazi F, Ni Y, Ngeow J, Sankunny M, Liu Z, Wei W, Mester JL, Keri RA, Zhang B, Eng C. Germline Heterozygous Variants in SEC23B Are Associated with Cowden Syndrome and Enriched in Apparently Sporadic Thyroid Cancer. American Journal of Human Genetics. 97: 661-676. PMID 26522472 DOI: 10.1016/J.Ajhg.2015.10.001  0.452
2015 Semple J, Metcalfe KA, Lubinski J, Huzarski T, Gronwald J, Armel S, Lynch HT, Karlan B, Foulkes W, Singer CF, Neuhausen SL, Eng C, Iqbal J, Narod SA. Does the age of breast cancer diagnosis in first-degree relatives impact on the risk of breast cancer in BRCA1 and BRCA2 mutation carriers? Breast Cancer Research and Treatment. 154: 163-9. PMID 26467043 DOI: 10.1007/S10549-015-3596-8  0.375
2015 Yamazaki K, Eng C, Kuznetsov SA, Reinisch J, Yamashita DD, Walker J, Cheung C, Robey PG, Yen SL. Missense mutation in the PTEN promoter of a patient with hemifacial hyperplasia. Bonekey Reports. 4: 654. PMID 26229595 DOI: 10.1038/Bonekey.2015.21  0.365
2015 Ngeow J, Liu C, Zhou K, Frick KD, Matchar DB, Eng C. Detecting Germline PTEN Mutations Among At-Risk Patients With Cancer: An Age- and Sex-Specific Cost-Effectiveness Analysis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 2537-44. PMID 26169622 DOI: 10.1200/Jco.2014.60.3456  0.478
2015 Ngeow J, Yu W, Yehia L, Niazi F, Chen J, Tang X, Heald B, Lei J, Romigh T, Tucker-Kellogg L, Lim KH, Song H, Eng C. Exome Sequencing Reveals Germline SMAD9 Mutation that Reduces PTEN Expression and is Associated with Hamartomatous Polyposis and Gastrointestinal Ganglioneuromas. Gastroenterology. PMID 26122142 DOI: 10.1053/J.Gastro.2015.06.027  0.504
2015 Sutton J, Orloff MS, Michener C, Chiesa-Vottero A, Prayson R, Nowacki AS, Eng C. Association of specific PTEN/10q haplotypes with endometrial cancer phenotypes in African-American and European American women. Gynecologic Oncology. PMID 26026735 DOI: 10.1016/J.Ygyno.2015.05.024  0.366
2015 Tilot AK, Frazier TW, Eng C. Balancing Proliferation and Connectivity in PTEN-associated Autism Spectrum Disorder. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 609-19. PMID 25916396 DOI: 10.1007/S13311-015-0356-8  0.454
2015 Bausch B, Wellner U, Peyre M, Boedeker CC, Hes FJ, Anglani M, de Campos JM, Kanno H, Maher ER, Krauss T, Sansó G, Barontini M, Letizia C, Hader C, Schiavi F, ... ... Eng C, et al. Characterization of endolymphatic sac tumors and von Hippel-Lindau disease in the International Endolymphatic Sac Tumor Registry. Head & Neck. PMID 25867206 DOI: 10.1002/Hed.24067  0.354
2015 Segev Y, Rosen B, Lubinski J, Gronwald J, Lynch HT, Moller P, Kim-Sing C, Ghadirian P, Karlan B, Eng C, Gilchrist D, Neuhausen SL, Eisen A, Friedman E, Euhus D, et al. Risk factors for endometrial cancer among women with a BRCA1 or BRCA2 mutation: a case control study. Familial Cancer. PMID 25838159 DOI: 10.1007/S10689-015-9798-8  0.368
2015 Tilot AK, Bebek G, Niazi F, Altemus JB, Romigh T, Frazier TW, Eng C. Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder. Molecular Psychiatry. PMID 25754085 DOI: 10.1038/Mp.2015.17  0.344
2015 Xekouki P, Szarek E, Bullova P, Giubellino A, Quezado M, Mastroyannis SA, Mastorakos P, Wassif CA, Raygada M, Rentia N, Dye L, Cougnoux A, Koziol D, Sierra Mde L, Lyssikatos C, ... ... Eng C, et al. Pituitary adenoma with paraganglioma/pheochromocytoma (3PAs) and succinate dehydrogenase defects in humans and mice. The Journal of Clinical Endocrinology and Metabolism. 100: E710-9. PMID 25695889 DOI: 10.1210/Jc.2014-4297  0.422
2015 Ni Y, Seballos S, Ganapathi S, Gurin D, Fletcher B, Ngeow J, Nagy R, Kloos RT, Ringel MD, LaFramboise T, Eng C. Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer. Endocrine-Related Cancer. 22: 121-30. PMID 25694510 DOI: 10.1530/Erc-14-0537  0.479
2015 Nizialek EA, Mester JL, Dhiman VK, Smiraglia DJ, Eng C. KLLN epigenotype-phenotype associations in Cowden syndrome. European Journal of Human Genetics : Ejhg. 23: 1538-43. PMID 25669429 DOI: 10.1038/Ejhg.2015.8  0.45
2015 von Dobschuetz E, Leijon H, Schalin-Jäntti C, Schiavi F, Brauckhoff M, Peczkowska M, Spiazzi G, Demattè S, Cecchini ME, Sartorato P, Krajewska J, Hasse-Lazar K, Roszkowska-Purska K, Taschin E, Malinoc A, ... ... Eng C, et al. A registry-based study of thyroid paraganglioma: histological and genetic characteristics. Endocrine-Related Cancer. 22: 191-204. PMID 25595276 DOI: 10.1530/Erc-14-0558  0.402
2015 Ngeow J, Eng C. PTEN hamartoma tumor syndrome: clinical risk assessment and management protocol. Methods (San Diego, Calif.). 77: 11-9. PMID 25461771 DOI: 10.1016/J.Ymeth.2014.10.011  0.483
2015 Mahdi H, Mester JL, Nizialek EA, Ngeow J, Michener C, Eng C. Germline PTEN, SDHB-D, and KLLN alterations in endometrial cancer patients with Cowden and Cowden-like syndromes: an international, multicenter, prospective study. Cancer. 121: 688-96. PMID 25376524 DOI: 10.1002/Cncr.29106  0.385
2015 Yu W, He X, Ni Y, Ngeow J, Eng C. Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation. Human Molecular Genetics. 24: 142-53. PMID 25149476 DOI: 10.1093/Hmg/Ddu425  0.455
2015 Mester J, Eng C. Cowden syndrome: Recognizing and managing a not-so-rare hereditary cancer syndrome Journal of Surgical Oncology. 111: 125-130. PMID 25132236 DOI: 10.1002/Jso.23735  0.393
2015 Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg LE, Sites E, Sandy A, Trimboli A, Fernandez SA, Eng C, Shapiro C, Leone G. Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis Oncogene. 34: 119-128. PMID 24276244 DOI: 10.1038/Onc.2013.511  0.323
2015 Sathyan P, Gurnani P, Lasecki D, Hicks K, Eng C, Rosenblatt KP. Role of combined germline pharmacogenomic and somatic genomic analysis in personalized cancer therapy: Non-small cell lung cancer (NSCLC) case study. Journal of Clinical Oncology. 33. DOI: 10.1200/Jco.2015.33.15_Suppl.E18551  0.417
2015 Funchain P, Sohal D, Khorana AA, Abraham J, Pennell NA, Rini BI, Dreicer R, Bolwell BJ, Eng C. Hereditary implications of somatic tumor testing. Journal of Clinical Oncology. 33: 1523-1523. DOI: 10.1200/Jco.2015.33.15_Suppl.1523  0.365
2015 Ngeow J, Liu C, Zhou K, Frick K, Matchar DB, Eng C. Abstract 3732: Detecting germline PTEN mutations among at-risk cancer patients: An age and gender-specific cost effectiveness analysis Cancer Research. 75: 3732-3732. DOI: 10.1158/1538-7445.Am2015-3732  0.434
2014 Ha D, Mester J, Eng C, Farha S. Pulmonary arterial hypertension in a patient with Cowden syndrome and the PTEN mutation. Pulmonary Circulation. 4: 728-31. PMID 25610608 DOI: 10.1086/678552  0.396
2014 Frazier TW, Embacher R, Tilot AK, Koenig K, Mester J, Eng C. Molecular and phenotypic abnormalities in individuals with germline heterozygous PTEN mutations and autism. Molecular Psychiatry. PMID 25288137 DOI: 10.1038/Mp.2014.125  0.4
2014 Nakashima MO, Shetty S, Chicka M, Flagg A, Eng C, Cotta CV. Transient abnormal myelopoiesis of a newborn not associated with chromosome 21 abnormalities or GATA1 mutations. Pediatric Blood & Cancer. PMID 25175265 DOI: 10.1002/Pbc.25226  0.452
2014 Stoffel EM, Eng C. Exome sequencing in familial colorectal cancer: Searching for needles in haystacks Gastroenterology. 147: 554-556. PMID 25075943 DOI: 10.1053/J.Gastro.2014.07.031  0.315
2014 Ngeow J, Eng C. TERT and BRAF in thyroid cancer: teaming up for trouble. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 2683-4. PMID 25024083 DOI: 10.1200/Jco.2014.56.5614  0.467
2014 Ngeow J, Eng C. BluepRINT for moderate-to-low penetrance cancer susceptibility genes needed: breast cancer and beyond. Cancer Discovery. 4: 762-3. PMID 25002613 DOI: 10.1158/2159-8290.Cd-14-0498  0.348
2014 Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, et al. A unified nomenclature and amino acid numbering for human PTEN. Science Signaling. 7: pe15. PMID 24985344 DOI: 10.1126/Scisignal.2005560  0.318
2014 Wang Y, Roma A, Nolley R, Abdul-Karim F, Peehl DM, Eng C. Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma. Endocrine-Related Cancer. 21: 579-86. PMID 24972837 DOI: 10.1530/Erc-14-0148  0.316
2014 Gronwald J, Robidoux A, Kim-Sing C, Tung N, Lynch HT, Foulkes WD, Manoukian S, Ainsworth P, Neuhausen SL, Demsky R, Eisen A, Singer CF, Saal H, Senter L, Eng C, et al. Duration of tamoxifen use and the risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment. 146: 421-7. PMID 24951267 DOI: 10.1007/S10549-014-3026-3  0.35
2014 Moline J, Eng C. Equality in Lynch syndrome screening: Why should we hold patients with endometrial cancer to a different standard? Journal of Clinical Oncology. 32: 2277. PMID 24912902 DOI: 10.1200/Jco.2014.55.3602  0.342
2014 Tan MH, Eng C. RE: Cowden syndrome and PTEN hamartoma tumor syndrome: Systematic review and revised diagnostic criteria Journal of the National Cancer Institute. 106. PMID 24899679 DOI: 10.1093/Jnci/Dju130  0.322
2014 Ngeow J, Stanuch K, Mester JL, Barnholtz-Sloan JS, Eng C. Second malignant neoplasms in patients with Cowden syndrome with underlying germline PTEN mutations. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 1818-24. PMID 24778394 DOI: 10.1200/Jco.2013.53.6656  0.465
2014 Ngeow J, Ni Y, Tohme R, Song Chen F, Bebek G, Eng C. Germline alterations in RASAL1 in Cowden syndrome patients presenting with follicular thyroid cancer and in individuals with apparently sporadic epithelial thyroid cancer. The Journal of Clinical Endocrinology and Metabolism. 99: E1316-21. PMID 24712574 DOI: 10.1210/Jc.2014-1225  0.412
2014 Mutter GL, Monte NM, Neuberg D, Ferenczy A, Eng C. Emergence, involution, and progression to carcinoma of mutant clones in normal endometrial tissues Cancer Research. 74: 2796-2802. PMID 24662919 DOI: 10.1158/0008-5472.Can-14-0108  0.3
2014 Tilot AK, Gaugler MK, Yu Q, Romigh T, Yu W, Miller RH, Frazier TW, Eng C. Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production. Human Molecular Genetics. 23: 3212-27. PMID 24470394 DOI: 10.1093/Hmg/Ddu031  0.34
2014 Kotsopoulos J, Lubinski J, Moller P, Lynch HT, Singer CF, Eng C, Neuhausen SL, Karlan B, Kim-Sing C, Huzarski T, Gronwald J, McCuaig J, Senter L, Tung N, Ghadirian P, et al. Timing of oral contraceptive use and the risk of breast cancer in BRCA1 mutation carriers. Breast Cancer Research and Treatment. 143: 579-86. PMID 24458845 DOI: 10.1007/S10549-013-2823-4  0.361
2014 Smith M, Mester J, Eng C. How to spot heritable breast cancer: a primary care physician's guide. Cleveland Clinic Journal of Medicine. 81: 31-40. PMID 24391105 DOI: 10.3949/Ccjm.81A.13051  0.324
2014 Wang Y, Yu Q, He X, Romigh T, Altemus J, Eng C. Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation. Molecular Cancer Therapeutics. 13: 517-27. PMID 24356815 DOI: 10.1158/1535-7163.Mct-13-0655  0.327
2014 Henderson CJ, Ngeow J, Collins MH, Martin LJ, Putnam PE, Abonia JP, Marsolo K, Eng C, Rothenberg ME. Increased prevalence of eosinophilic gastrointestinal disorders in pediatric PTEN hamartoma tumor syndromes. Journal of Pediatric Gastroenterology and Nutrition. 58: 553-60. PMID 24345843 DOI: 10.1097/Mpg.0000000000000253  0.375
2014 Bausch B, Wellner U, Bausch D, Schiavi F, Barontini M, Sanso G, Walz MK, Peczkowska M, Weryha G, Dall'igna P, Cecchetto G, Bisogno G, Moeller LC, Bockenhauer D, Patocs A, ... ... Eng C, et al. Long-term prognosis of patients with pediatric pheochromocytoma. Endocrine-Related Cancer. 21: 17-25. PMID 24169644 DOI: 10.1530/Erc-13-0415  0.441
2014 Hobert JA, Embacher R, Mester JL, Frazier TW, Eng C. Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly. European Journal of Human Genetics : Ejhg. 22: 273-6. PMID 23695273 DOI: 10.1038/Ejhg.2013.114  0.373
2014 Mahdi H, Woessner JR, Buechel M, Moline J, Eng C, Michener C, Rose PG. Outcome and response to neoadjuvant chemotherapy in patients with advanced stage Müllerian cancer in BRCA1/2 mutation-positive compared to mutation-negative women Gynecologic Oncology. 133: 86. DOI: 10.1016/J.Ygyno.2014.03.230  0.412
2014 Mahdi H, Mester JL, Nizialek E, Michener C, Eng C. Germline SDHB/C/D variation and KLLN promoter methylation in endometrial cancer patients with Cowden and Cowden-like syndrome Gynecologic Oncology. 133: 78. DOI: 10.1016/J.Ygyno.2014.03.210  0.331
2014 Mahdi H, Mester JL, Michener C, Eng C. Prevalence and clinical predictors of germline PTEN mutation in endometrial cancer patients with Cowden and Cowden-like syndrome Gynecologic Oncology. 133: 77-78. DOI: 10.1016/J.Ygyno.2014.03.209  0.467
2013 Ngeow J, Nizialek E, Eng C. Into the eye of the storm: breast cancer's somatic mutation landscape points to DNA damage and repair. Translational Cancer Research. 2: 59-61. PMID 26613077 DOI: 10.21037/1116  0.444
2013 Ngeow J, Eng C. RASAL1 in thyroid cancer: wisdom from an old foe. Journal of the National Cancer Institute. 105: 1597-9. PMID 24136888 DOI: 10.1093/Jnci/Djt291  0.309
2013 Valentini A, Lubinski J, Byrski T, Ghadirian P, Moller P, Lynch HT, Ainsworth P, Neuhausen SL, Weitzel J, Singer CF, Olopade OI, Saal H, Lyonnet DS, Foulkes WD, Kim-Sing C, ... ... Eng C, et al. The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation. Breast Cancer Research and Treatment. 142: 177-85. PMID 24136669 DOI: 10.1007/S10549-013-2729-1  0.368
2013 Mester JL, Moore RA, Eng C. PTEN germline mutations in patients initially tested for other hereditary cancer syndromes: would use of risk assessment tools reduce genetic testing? The Oncologist. 18: 1083-90. PMID 24037976 DOI: 10.1634/Theoncologist.2013-0174  0.453
2013 Bausch B, Jilg C, Gläsker S, Vortmeyer A, Lützen N, Anton A, Eng C, Neumann HP. Renal cancer in von Hippel-Lindau disease and related syndromes. Nature Reviews. Nephrology. 9: 529-38. PMID 23897319 DOI: 10.1038/Nrneph.2013.144  0.395
2013 Hopman SM, Merks JH, de Borgie CA, Aalfs CM, Biesecker LG, Cole T, Eng C, Legius E, Maher ER, van Noesel MM, Verloes A, Viskochil DH, Wagner A, Weksberg R, Caron HN, et al. The development of a clinical screening instrument for tumour predisposition syndromes in childhood cancer patients. European Journal of Cancer (Oxford, England : 1990). 49: 3247-54. PMID 23855994 DOI: 10.1016/J.Ejca.2013.06.015  0.34
2013 Semple J, Metcalfe KA, Lynch HT, Kim-Sing C, Senter L, Pal T, Ainsworth P, Lubinski J, Tung N, Eng C, Gilchrist D, Blum J, Neuhausen SL, Singer CF, Ghadirian P, et al. International rates of breast reconstruction after prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers. Annals of Surgical Oncology. 20: 3817-22. PMID 23740344 DOI: 10.1245/S10434-013-3040-4  0.358
2013 Ngeow J, Eng C. Population-based universal screening for Lynch syndrome: ready, set... How? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 2527-9. PMID 23733783 DOI: 10.1200/Jco.2013.50.4373  0.398
2013 Farley MN, Schmidt LS, Mester JL, Peña-Llopis S, Pavia-Jimenez A, Christie A, Vocke CD, Ricketts CJ, Peterson J, Middelton L, Kinch L, Grishin N, Merino MJ, Metwalli AR, Xing C, ... ... Eng C, et al. A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma. Molecular Cancer Research : McR. 11: 1061-71. PMID 23709298 DOI: 10.1158/1541-7786.Mcr-13-0111  0.477
2013 Mester J, Eng C. When overgrowth bumps into cancer: the PTEN-opathies. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 163: 114-21. PMID 23613428 DOI: 10.1002/ajmg.c.31364  0.331
2013 Moline J, Mahdi H, Yang B, Biscotti C, Roma AA, Heald B, Rose PG, Michener C, Eng C. Implementation of tumor testing for lynch syndrome in endometrial cancers at a large academic medical center. Gynecologic Oncology. 130: 121-6. PMID 23612316 DOI: 10.1016/J.Ygyno.2013.04.022  0.375
2013 Mester J, Eng C. When Overgrowth Bumps Into Cancer: The PTEN-Opathies. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. PMID 23576530 DOI: 10.1002/J.1552-4876.2013.31364.X  0.441
2013 He X, Arrotta N, Radhakrishnan D, Wang Y, Romigh T, Eng C. Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity. Cancer Research. 73: 3029-40. PMID 23475934 DOI: 10.1158/0008-5472.Can-12-3811  0.468
2013 Busch RM, Chapin JS, Mester J, Ferguson L, Haut JS, Frazier TW, Eng C. Cognitive characteristics of PTEN hamartoma tumor syndromes. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 15: 548-53. PMID 23470840 DOI: 10.1038/Gim.2013.1  0.392
2013 Nizialek EA, Peterson C, Mester JL, Downes-Kelly E, Eng C. Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest. Human Molecular Genetics. 22: 2451-61. PMID 23446638 DOI: 10.1093/Hmg/Ddt097  0.42
2013 Wang Y, He X, Yu Q, Eng C. Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas. Human Molecular Genetics. 22: 2263-72. PMID 23418309 DOI: 10.1093/Hmg/Ddt077  0.348
2013 Heald B, Plesec T, Liu X, Pai R, Patil D, Moline J, Sharp RR, Burke CA, Kalady MF, Church J, Eng C. Implementation of universal microsatellite instability and immunohistochemistry screening for diagnosing lynch syndrome in a large academic medical center. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 1336-40. PMID 23401454 DOI: 10.1200/Jco.2012.45.1674  0.304
2013 Ngeow J, Heald B, Rybicki LA, Orloff MS, Chen JL, Liu X, Yerian L, Willis J, Lehtonen HJ, Lehtonen R, Mester JL, Moline J, Burke CA, Church J, Aaltonen LA, ... Eng C, et al. Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps. Gastroenterology. 144: 1402-9, 1409.e1-5. PMID 23399955 DOI: 10.1053/J.Gastro.2013.02.001  0.456
2013 Granados A, Eng C, Diaz A. Brothers with germline PTEN mutations and persistent hypoglycemia, macrocephaly, developmental delay, short stature, and coagulopathy. Journal of Pediatric Endocrinology & Metabolism : Jpem. 26: 137-41. PMID 23382303 DOI: 10.1515/Jpem-2012-0227  0.458
2013 Neumann HP, Jilg C, Bacher J, Nabulsi Z, Malinoc A, Hummel B, Hoffmann MM, Ortiz-Bruechle N, Glasker S, Pisarski P, Neeff H, Krämer-Guth A, Cybulla M, Hornberger M, Wilpert J, ... ... Eng C, et al. Epidemiology of autosomal-dominant polycystic kidney disease: an in-depth clinical study for south-western Germany. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 28: 1472-87. PMID 23300259 DOI: 10.1093/Ndt/Gfs551  0.326
2013 Orloff MS, He X, Peterson C, Chen F, Chen JL, Mester JL, Eng C. Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. American Journal of Human Genetics. 92: 76-80. PMID 23246288 DOI: 10.1016/J.Ajhg.2012.10.021  0.5
2013 Ngeow JY, Mester J, Mahdi H, Yehia L, Barnholtz-Sloan J, Eng C. Second malignant neoplasms (SMN) in Cowden syndrome patients with underlying germline PTEN mutations. Journal of Clinical Oncology. 31: 1527-1527. DOI: 10.1200/Jco.2013.31.15_Suppl.1527  0.406
2013 Hopman SMJ, Merks JHM, Borgie CAJMd, Biesecker LG, Cole T, Eng C, Legius E, Maher ER, Meer CAvd, Noesel MMv, Verloes A, Viskochil DH, Wagner A, Weksberg R, Caron HN, et al. The development of a clinical screening tool for tumour predisposition syndromes in childhood cancer patients Tijdschrift Voor Kindergeneeskunde. 81: 52-52. DOI: 10.1007/S12456-013-0051-9  0.341
2012 Ngeow J, Eng C. Thyroid cancer genetics: how close are we to personalizing clinical management? Personalized Medicine. 9: 355-358. PMID 29776255 DOI: 10.2217/Pme.12.31  0.313
2012 Milas M, Mester J, Metzger R, Shin J, Mitchell J, Berber E, Siperstein AE, Eng C. Should patients with Cowden syndrome undergo prophylactic thyroidectomy? Surgery. 152: 1201-10. PMID 23158187 DOI: 10.1016/J.Surg.2012.08.055  0.41
2012 Neumann HP, Malinoc A, Bacher J, Nabulsi Z, Ivanovas V, Bruechle NO, Mader I, Hoffmann MM, Riegler P, Kraemer-Guth A, Burchardi C, Schaeffner E, Martin RS, Azurmendi PJ, Zerres K, ... ... Eng C, et al. Characteristics of intracranial aneurysms in the else kröner-fresenius registry of autosomal dominant polycystic kidney disease. Cerebrovascular Diseases Extra. 2: 71-9. PMID 23139683 DOI: 10.1159/000342620  0.382
2012 Lewis CM, Bu D, Sarode V, Robinson L, Wilson KS, Viscusi RK, Eng C, Euhus DM. The clinical consequences of hemizygosity across 2 MB of 10q23 are restricted to Cowden syndrome. Breast Cancer Research and Treatment. 136: 911-8. PMID 23132533 DOI: 10.1007/S10549-012-2322-Z  0.425
2012 Ngeow J, He X, Mester JL, Lei J, Romigh T, Orloff MS, Milas M, Eng C. Utility of PTEN protein dosage in predicting for underlying germline PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes. The Journal of Clinical Endocrinology and Metabolism. 97: E2320-7. PMID 23066114 DOI: 10.1210/Jc.2012-2944  0.456
2012 He X, Saji M, Radhakrishnan D, Romigh T, Ngeow J, Yu Q, Wang Y, Ringel MD, Eng C. PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome. The Journal of Clinical Endocrinology and Metabolism. 97: E2179-87. PMID 22962422 DOI: 10.1210/Jc.2012-1991  0.42
2012 Ni Y, Eng C. Vitamin E protects against lipid peroxidation and rescues tumorigenic phenotypes in cowden/cowden-like patient-derived lymphoblast cells with germline SDHx variants Clinical Cancer Research. 18: 4954-4961. PMID 22829200 DOI: 10.1158/1078-0432.Ccr-12-1055  0.316
2012 O'Malley M, LaGuardia L, Kalady MF, Parambil J, Heald B, Eng C, Church J, Burke CA. The prevalence of hereditary hemorrhagic telangiectasia in juvenile polyposis syndrome. Diseases of the Colon and Rectum. 55: 886-92. PMID 22810475 DOI: 10.1097/Dcr.0B013E31825Aad32  0.417
2012 Hopman SMJ, Rijn RRV, Eng C, Bras J, Alders M, Horst CMvd, Hennekam RCM, Merks JHM. PTEN hamartoma tumor syndrome and Gorham-Stout phenomenon. American Journal of Medical Genetics Part A. 158: 1719-1723. PMID 22628360 DOI: 10.1002/Ajmg.A.35406  0.469
2012 Mester J, Eng C. Estimate of de novo mutation frequency in probands with PTEN hamartoma tumor syndrome Genetics in Medicine. 14: 819-822. PMID 22595938 DOI: 10.1038/Gim.2012.51  0.483
2012 Kotsopoulos J, Lubinski J, Lynch HT, Kim-Sing C, Neuhausen S, Demsky R, Foulkes WD, Ghadirian P, Tung N, Ainsworth P, Senter L, Karlan B, Eisen A, Eng C, Weitzel J, et al. Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers Cancer Epidemiology Biomarkers and Prevention. 21: 1089-1096. PMID 22564871 DOI: 10.1158/1055-9965.Epi-12-0201  0.37
2012 Hesson LB, Packham D, Pontzer E, Funchain P, Eng C, Ward RL. A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines. Biological Procedures Online. 14: 5. PMID 22490388 DOI: 10.1186/1480-9222-14-5  0.353
2012 Tuupanen S, Yan J, Turunen M, Gylfe AE, Kaasinen E, Li L, Eng C, Culver DA, Kalady MF, Pennison MJ, Pasche B, Manne U, de la Chapelle A, Hampel H, Henderson BE, et al. Characterization of the colorectal cancer-associated enhancer MYC-335 at 8q24: the role of rs67491583. Cancer Genetics. 205: 25-33. PMID 22429595 DOI: 10.1016/J.Cancergen.2012.01.005  0.321
2012 Kotsopoulos J, Lubinski J, Salmena L, Lynch HT, Kim-Sing C, Foulkes WD, Ghadirian P, Neuhausen SL, Demsky R, Tung N, Ainsworth P, Senter L, Eisen A, Eng C, Singer C, et al. Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers Breast Cancer Research. 14. PMID 22405187 DOI: 10.1186/Bcr3138  0.405
2012 Orloff MS, Zhang L, Bebek G, Eng C. Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort. Plos One. 7: e31975. PMID 22384118 DOI: 10.1371/Journal.Pone.0031975  0.322
2012 Mester JL, Zhou M, Prescott N, Eng C. Papillary Renal Cell Carcinoma is Associated with PTEN Hamartoma Tumor Syndrome Urology. 79: 1187. PMID 22381246 DOI: 10.1016/J.Urology.2011.12.025  0.391
2012 Malinoc A, Sullivan M, Wiech T, Kurt Werner S, Jilg C, Straeter J, Deger S, Hoffmann MM, Bosse A, Rasp G, Eng C, Neumann HP. Biallelic inactivation of the SDHC gene in renal carcinoma associated with paraganglioma syndrome type 3. Endocrine-Related Cancer. 19: 283-90. PMID 22351710 DOI: 10.1530/Erc-11-0324  0.497
2012 Ashida S, Orloff MS, Bebek G, Zhang L, Zheng P, Peehl DM, Eng C. Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 1578-87. PMID 22275508 DOI: 10.1158/1078-0432.Ccr-11-2535  0.309
2012 Heindl M, Hndel N, Ngeow J, Kionke J, Wittekind C, Kamprad M, Rensing-Ehl A, Ehl S, Reifenberger J, Loddenkemper C, Maul J, Hoffmeister A, Aretz S, Kiess W, Eng C, et al. Autoimmunity, intestinal lymphoid hyperplasia, and defects in mucosal B-cell homeostasis in patients with PTEN hamartoma tumor syndrome Gastroenterology. 142: 1093-1096.e6. PMID 22266152 DOI: 10.1053/J.Gastro.2012.01.011  0.323
2012 Hobert JA, Mester JL, Moline J, Eng C. Elevated plasma succinate in PTEN, SDHB, and SDHD mutation-positive individuals. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 14: 616-9. PMID 22261759 DOI: 10.1038/Gim.2011.63  0.462
2012 Tan MH, Mester JL, Ngeow J, Rybicki LA, Orloff MS, Eng C. Lifetime cancer risks in individuals with germline PTEN mutations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 400-7. PMID 22252256 DOI: 10.1158/1078-0432.Ccr-11-2283  0.472
2012 Heald B, Edelman E, Eng C. Prospective comparison of family medical history with personal genome screening for risk assessment of common cancers. European Journal of Human Genetics : Ejhg. 20: 547-51. PMID 22215421 DOI: 10.1038/Ejhg.2011.224  0.338
2012 Bebek G, Bennett KL, Funchain P, Campbell R, Seth R, Scharpf J, Burkey B, Eng C. Microbiomic subprofiles and MDR1 promoter methylation in head and neck squamous cell carcinoma. Human Molecular Genetics. 21: 1557-65. PMID 22180460 DOI: 10.1093/Hmg/Ddr593  0.325
2012 Wang Y, He X, Ngeow J, Eng C. GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen receptor and by androgen-independent suppression of PTEN transcription in breast cancer. Human Molecular Genetics. 21: 569-76. PMID 22021428 DOI: 10.1093/Hmg/Ddr491  0.333
2012 Ni Y, He X, Chen J, Moline J, Mester J, Orloff MS, Ringel MD, Eng C. Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53. Human Molecular Genetics. 21: 300-10. PMID 21979946 DOI: 10.1093/Hmg/Ddr459  0.442
2012 Tan MH, De S, Bebek G, Orloff MS, Wesolowski R, Downs-Kelly E, Budd GT, Stark GR, Eng C. Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer. Breast Cancer Research and Treatment. 131: 849-58. PMID 21479552 DOI: 10.1007/S10549-011-1500-8  0.315
2012 Aaltonen LA, Roth S, Eng C. 18 Direct Sequencing for Cowden Syndrome Gene PTEN (MMAC1) Mutations. Methods in Molecular Medicine. 50: 185-93. PMID 21318827 DOI: 10.1385/1-59259-084-5:185  0.351
2012 Ngeow J, Eng C. PTEN mutations: Help spot thyroid cancer before it occurs Expert Review of Endocrinology and Metabolism. 7: 251-254. DOI: 10.1586/Eem.12.15  0.45
2012 Funchain P, Bebek G, Bennett KL, Burkey B, Eng C. Correlation of microbiomic profiles with disease status and MDR1 methylation in head and neck squamous cell carcinoma (HNSCC). Journal of Clinical Oncology. 30: 5573-5573. DOI: 10.1200/Jco.2012.30.15_Suppl.5573  0.324
2012 Mester J, Moore R, Eng C. PTEN germline mutations in patients first tested for other hereditary cancer syndromes: Would use of risk assessment tools have reduced health care costs? Journal of Clinical Oncology. 30: 1516-1516. DOI: 10.1200/Jco.2012.30.15_Suppl.1516  0.489
2012 Ngeow JYY, He X, Mester J, Radhakrishnan D, Lei J, Romigh T, Milas M, Eng C. Use of PTEN protein dosage to predict for underlying germ-line PTEN mutations among patients presenting with thyroid cancer and Cowden-like phenotypes. Journal of Clinical Oncology. 30: 1508-1508. DOI: 10.1200/Jco.2012.30.15_Suppl.1508  0.472
2012 Wang Y, He X, Eng C. Abstract 4855: KLLN, which shares a bidirectional promoter with PTEN, is an AR-regulated tumor suppressor, and induces p53-dependent and -independent apoptosis in breast cancer Cancer Research. 72: 4855-4855. DOI: 10.1158/1538-7445.Am2012-4855  0.352
2012 Bebek G, Bennett KL, Funchain P, Campbell R, Seth R, Scharpf J, Burkey B, Eng C. Abstract 4087: Microbiomic subprofiles and MDR1 promoter methylation in head and neck squamous cell carcinoma Cancer Research. 72: 4087-4087. DOI: 10.1158/1538-7445.Am2012-4087  0.318
2012 Ni Y, Eng C. Abstract 1120: α-Tocopherol protects cells from lipid peroxidation and rescues tumorigenic phenotypes in CS/CSL patients with germline SDHx variants Cancer Research. 72: 1120-1120. DOI: 10.1158/1538-7445.Am2012-1120  0.394
2012 Tan MH, Mester J, Eng C. Lifetime Cancer Risks of PTEN Mutation Carriers—Response Clinical Cancer Research. 18: 4214-4214. DOI: 10.1158/1078-0432.Ccr-12-1128  0.448
2012 Mester J, Escobar P, Roma A, Eng C. Risk for endometrial carcinoma, ovarian tumors and other gynecologic diagnoses in a prospective series of women with cowden syndrome and germline PTEN mutation Gynecologic Oncology. 125. DOI: 10.1016/J.Ygyno.2011.12.075  0.426
2011 Levi Z, Baris HN, Kedar I, Niv Y, Geller A, Gal E, Gingold R, Morgenstern S, Baruch Y, Leach BH, Bronner MP, Eng C. Upper and Lower Gastrointestinal Findings in PTEN Mutation-Positive Cowden Syndrome Patients Participating in an Active Surveillance Program. Clinical and Translational Gastroenterology. 2: e5. PMID 23238744 DOI: 10.1038/Ctg.2011.4  0.47
2011 Moline J, Ngeow J, Rajiah P, Eng C. Evil lurks in the heart of man: cardiac paraganglioma presenting as recurrent dyspnoea and chronic cough Case Reports. 2011. PMID 22670000 DOI: 10.1136/Bcr.11.2011.5170  0.399
2011 Ngeow J, Mester J, Rybicki LA, Ni Y, Milas M, Eng C. Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations. The Journal of Clinical Endocrinology and Metabolism. 96: E2063-71. PMID 21956414 DOI: 10.1210/Jc.2011-1616  0.424
2011 Sullivan M, Rybicki LA, Winter A, Hoffmann MM, Reiermann S, Linke H, Arbeiter K, Patzer L, Budde K, Hoppe B, Zeier M, Lhotta K, Bock A, Wiech T, Gaspert A, ... ... Eng C, et al. Age-related penetrance of hereditary atypical hemolytic uremic syndrome. Annals of Human Genetics. 75: 639-47. PMID 21906045 DOI: 10.1111/J.1469-1809.2011.00671.X  0.472
2011 Bebek G, Orloff M, Eng C. Microenvironmental genomic alterations reveal signaling networks for head and neck squamous cell carcinoma. Journal of Clinical Bioinformatics. 1: 21-21. PMID 21884569 DOI: 10.1186/2043-9113-1-21  0.324
2011 Orloff M, Peterson C, He X, Ganapathi S, Heald B, Yang YR, Bebek G, Romigh T, Song JH, Wu W, David S, Cheng Y, Meltzer SJ, Eng C. Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. Jama. 306: 410-9. PMID 21791690 DOI: 10.1001/Jama.2011.1029  0.473
2011 Limbach AL, Ni Y, Huang J, Eng C, Magi-Galluzzi C. Adenomatoid tumour of the adrenal gland in a patient with germline SDHD mutation: a case report and review of the literature. Pathology. 43: 495-8. PMID 21753715 DOI: 10.1097/Pat.0B013E3283486Bb9  0.381
2011 Neumann HP, Sullivan M, Winter A, Malinoc A, Hoffmann MM, Boedeker CC, Bertz H, Walz MK, Moeller LC, Schmid KW, Eng C. Germline mutations of the TMEM127 gene in patients with paraganglioma of head and neck and extraadrenal abdominal sites. The Journal of Clinical Endocrinology and Metabolism. 96: E1279-82. PMID 21613359 DOI: 10.1210/Jc.2011-0114  0.48
2011 Bennett KL, Campbell R, Ganapathi S, Zhou M, Rini B, Ganapathi R, Neumann HP, Eng C. Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma. Genes, Chromosomes & Cancer. 50: 654-61. PMID 21584899 DOI: 10.1002/Gcc.20887  0.344
2011 Moline J, Eng C. Multiple endocrine neoplasia type 2: An overview Genetics in Medicine. 13: 755-764. PMID 21552134 DOI: 10.1097/Gim.0B013E318216Cc6D  0.371
2011 Wang Y, Romigh T, He X, Tan MH, Orloff MS, Silverman RH, Heston WD, Eng C. Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers Oncogene. 30: 4327-4338. PMID 21532617 DOI: 10.1038/Onc.2011.144  0.347
2011 Nagy R, Ganapathi S, Comeras I, Peterson C, Orloff M, Porter K, Eng C, Ringel MD, Kloos RT. Frequency of germline PTEN mutations in differentiated thyroid cancer. Thyroid : Official Journal of the American Thyroid Association. 21: 505-10. PMID 21417916 DOI: 10.1089/Thy.2010.0365  0.494
2011 Tan MH, Eng C. Testicular microlithiasis: Recent advances in understanding and management Nature Reviews Urology. 8: 153-163. PMID 21394177 DOI: 10.1038/Nrurol.2011.1  0.355
2011 Mester JL, Tilot AK, Rybicki LA, Frazier TW, Eng C. Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model. European Journal of Human Genetics : Ejhg. 19: 763-8. PMID 21343951 DOI: 10.1038/Ejhg.2011.20  0.408
2011 Kalady MF, Jarrar A, Leach B, LaGuardia L, O'Malley M, Eng C, Church JM. Defining phenotypes and cancer risk in hyperplastic polyposis syndrome. Diseases of the Colon & Rectum. 54: 164-170. PMID 21228663 DOI: 10.1007/Dcr.0B013E3181Fd4C15  0.396
2011 Tan MH, Mester J, Peterson C, Yang Y, Chen JL, Rybicki LA, Milas K, Pederson HJ, Remzi B, Orloff MS, Eng C. A Clinical Scoring System for Selection of Patients for PTEN Mutation Testing Is Proposed on the Basis of a Prospective Study of 3042 Probands American Journal of Human Genetics. 88: 42-56. PMID 21194675 DOI: 10.1016/J.Ajhg.2010.11.013  0.467
2011 von Dücker L, Walz MK, Voss C, Arnold G, Eng C, Neumann HP. Laparoscopic organ-sparing resection of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors. World Journal of Surgery. 35: 563-7. PMID 21181474 DOI: 10.1007/S00268-010-0878-5  0.313
2011 Torres V, Triozzi P, Eng C, Tubbs R, Schoenfiled L, Crabb JW, Saunthararajah Y, Singh AD. Circulating tumor cells in uveal melanoma. Future Oncology. 7: 101-109. PMID 21174541 DOI: 10.2217/Fon.10.143  0.316
2011 He X, Wang Y, Zhu J, Orloff M, Eng C. Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling. Cancer Letters. 301: 168-76. PMID 21168265 DOI: 10.1016/J.Canlet.2010.11.012  0.305
2011 Frank-Raue K, Rybicki LA, Erlic Z, Schweizer H, Winter A, Milos I, Toledo SP, Toledo RA, Tavares MR, Alevizaki M, Mian C, Siggelkow H, Hüfner M, Wohllk N, Opocher G, ... ... Eng C, et al. Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10. Human Mutation. 32: 51-8. PMID 20979234 DOI: 10.1002/Humu.21385  0.452
2011 O’Malley M, LaGuardia L, Kalady M, Parambil J, Leach B, Eng C, Church J, Burke C. The prevalence of hereditary hemorrhagic telangiectasia in Juvenile Polyposis syndrome patients with SMAD4 mutations Hereditary Cancer in Clinical Practice. 9: 1-2. DOI: 10.1186/1897-4287-9-S1-O5  0.461
2011 Heald B, Eng C. Comparison of family health history to personal genomic screening for risk assessment of colon cancer Hereditary Cancer in Clinical Practice. 9: 1-1. DOI: 10.1186/1897-4287-9-S1-O2  0.328
2010 Bennett KL, Mester J, Eng C. Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome. Jama. 304: 2724-31. PMID 21177507 DOI: 10.1001/Jama.2010.1877  0.451
2010 Eng C. Mendelian genetics of rare-and not so rare-cancers Annals of the New York Academy of Sciences. 1214: 70-82. PMID 20946573 DOI: 10.1111/J.1749-6632.2010.05789.X  0.507
2010 He X, Ni Y, Wang Y, Romigh T, Eng C. Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53. Human Molecular Genetics. 20: 80-9. PMID 20926450 DOI: 10.1093/Hmg/Ddq434  0.427
2010 Erlic Z, Ploeckinger U, Cascon A, Hoffmann MM, von Duecker L, Winter A, Kammel G, Bacher J, Sullivan M, Isermann B, Fischer L, Raffel A, Knoefel WT, Schott M, Baumann T, ... ... Eng C, et al. Systematic comparison of sporadic and syndromic pancreatic islet cell tumors. Endocrine-Related Cancer. 17: 875-83. PMID 20660572 DOI: 10.1677/Erc-10-0037  0.44
2010 Heald B, Mester J, Rybicki L, Orloff MS, Burke CA, Eng C. Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers Gastroenterology. 139: 1927-1933. PMID 20600018 DOI: 10.1053/J.Gastro.2010.06.061  0.481
2010 Shiovitz S, Everett J, Huang SC, Orloff MS, Eng C, Gruber SB. Head circumference in the clinical detection of PTEN hamartoma tumor syndrome in a clinic population at high-risk of breast cancer. Breast Cancer Research and Treatment. 124: 459-65. PMID 20349131 DOI: 10.1007/S10549-010-0839-6  0.409
2010 Eng C. Common alleles of predisposition in endocrine neoplasia Current Opinion in Genetics and Development. 20: 251-256. PMID 20211557 DOI: 10.1016/J.Gde.2010.02.004  0.432
2010 Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, ... ... Eng C, et al. Allele-specific tumor spectrum in pten knockin mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 5142-7. PMID 20194734 DOI: 10.1073/Pnas.0912524107  0.461
2010 Waddell N, Arnold J, Cocciardi S, da Silva L, Marsh A, Riley J, Johnstone CN, Orloff M, Assie G, Eng C, Reid L, Keith P, Yan M, Fox S, Devilee P, et al. Subtypes of familial breast tumours revealed by expression and copy number profiling. Breast Cancer Research and Treatment. 123: 661-77. PMID 19960244 DOI: 10.1007/S10549-009-0653-1  0.37
2010 Erlic Z, Hoffmann MM, Sullivan M, Franke G, Peczkowska M, Harsch I, Schott M, Gabbert HE, Valimäki M, Preuss SF, Hasse-Lazar K, Waligorski D, Robledo M, Januszewicz A, Eng C, et al. Pathogenicity of DNA variants and double mutations in multiple endocrine neoplasia type 2 and von Hippel-Lindau syndrome. The Journal of Clinical Endocrinology and Metabolism. 95: 308-13. PMID 19906784 DOI: 10.1210/Jc.2009-1728  0.441
2010 Kirches E, Steiner J, Schneider T, Vorwerk CK, Scherlach C, Holtkamp N, Keilhoff G, Eng C, Mawrin C. Lhermitte-Duclos disease caused by a novel germline PTEN mutation R173P in a patient presenting with psychosis. Neuropathology and Applied Neurobiology. 36: 86-9. PMID 19719509 DOI: 10.1111/J.1365-2990.2009.01041.X  0.434
2010 Wesolowski R, Orloff M, Downs-Kelly E, Budd GT, Stark GR, De S, Tubbs RR, Crowe JP, Eng C. Effect of kinesins on taxane resistance. Journal of Clinical Oncology. 28: 10545-10545. DOI: 10.1200/Jco.2010.28.15_Suppl.10545  0.332
2010 Heald B, Mester J, Eng C. Gastrointestinal polyposis and PTEN mutations: an under-acknowledged diagnostic criterion Hereditary Cancer in Clinical Practice. 8: 1-1. DOI: 10.1186/1897-4287-8-S1-O3  0.436
2010 Eng C. Abstract CN04-04: Cancer predisposition: I say genetics, you say genomics, but are we there yet? Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-Cn04-04  0.403
2010 Bennett KL, Romigh T, Lee W, Lamarre E, Zhang X, Seth R, Scharpf J, Hunt J, Eng C. Abstract 4911: HPV-independent methylation of specific TGF-B pathway-relevant genes in head and neck squamous cell carcinomas associated with prior radiation therapy and exposure to alcohol and tobacco Cancer Research. 70: 4911-4911. DOI: 10.1158/1538-7445.Am10-4911  0.312
2010 Tuupanen S, Yan J, Turunen M, Gylfe A, Li L, Eng C, Culver D, Kalady M, Chapelle Adl, Askhtorab H, Smooth D, Sandler R, Keku T, Ellis N, Kupfer S, et al. Abstract 4731: Resequencing of the MYC-335 enhancer in the colorectal cancer associated 8q24 region Cancer Research. 70: 4731-4731. DOI: 10.1158/1538-7445.Am10-4731  0.342
2010 Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen H, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Perle KL, Stromberg P, Rosol TJ, Eng C, et al. Abstract 3260: Allele-specific tumor spectrum inPtenknockin mice Cancer Research. 70: 3260-3260. DOI: 10.1158/1538-7445.Am10-3260  0.455
2010 Orloff M, Elson P, Yang Y, Eng C, Hansel DE. Abstract 1810: PTEN association with mTOR pathway activation and outcomes in bladder cancer Cancer Research. 70: 1810-1810. DOI: 10.1158/1538-7445.Am10-1810  0.382
2009 Qian CN, Furge KA, Knol J, Huang D, Chen J, Dykema KJ, Kort EJ, Massie A, Khoo SK, Vanden Beldt K, Resau JH, Anema J, Kahnoski RJ, Morreau H, Camparo P, ... ... Eng C, et al. Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models. Cancer Research. 69: 8256-64. PMID 19843858 DOI: 10.1158/0008-5472.Can-09-1689  0.34
2009 Erlic Z, Rybicki L, Peczkowska M, Golcher H, Kann PH, Brauckhoff M, Müssig K, Muresan M, Schäffler A, Reisch N, Schott M, Fassnacht M, Opocher G, Klose S, Fottner C, ... ... Eng C, et al. Clinical predictors and algorithm for the genetic diagnosis of pheochromocytoma patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6378-85. PMID 19825962 DOI: 10.1158/1078-0432.Ccr-09-1237  0.437
2009 Hobert JA, Eng C. PTEN hamartoma tumor syndrome: an overview. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 11: 687-94. PMID 19668082 DOI: 10.1097/Gim.0B013E3181Ac9Aea  0.394
2009 Neumann HPH, Eng C. The approach to the patient with paraganglioma Journal of Clinical Endocrinology and Metabolism. 94: 2677-2683. PMID 19657044 DOI: 10.1210/Jc.2009-0496  0.452
2009 Kloos RT, Eng C, Evans DB, Francis GL, Gagel RF, Gharib H, Moley JF, Pacini F, Ringel MD, Schlumberger M, Wells SA. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid : Official Journal of the American Thyroid Association. 19: 565-612. PMID 19469690 DOI: 10.1089/Thy.2008.0403  0.314
2009 Lobo GP, Waite KA, Planchon SM, Romigh T, Nassif NT, Eng C. Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function. Human Molecular Genetics. 18: 2851-62. PMID 19457929 DOI: 10.1093/Hmg/Ddp220  0.442
2009 Zhao Y, Marotta M, Eichler EE, Eng C, Tanaka H. Linkage disequilibrium between two high-frequency deletion polymorphisms: implications for association studies involving the glutathione-S transferase (GST) genes. Plos Genetics. 5: e1000472. PMID 19424424 DOI: 10.1371/Journal.Pgen.1000472  0.342
2009 Neumann HP, Erlic Z, Boedeker CC, Rybicki LA, Robledo M, Hermsen M, Schiavi F, Falcioni M, Kwok P, Bauters C, Lampe K, Fischer M, Edelman E, Benn DE, Robinson BG, ... ... Eng C, et al. Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out. Cancer Research. 69: 3650-6. PMID 19351833 DOI: 10.1158/0008-5472.Can-08-4057  0.44
2009 Boedeker CC, Erlic Z, Richard S, Kontny U, Gimenez-Roqueplo AP, Cascon A, Robledo M, de Campos JM, van Nederveen FH, de Krijger RR, Burnichon N, Gaal J, Walter MA, Reschke K, Wiech T, ... ... Eng C, et al. Head and neck paragangliomas in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. The Journal of Clinical Endocrinology and Metabolism. 94: 1938-44. PMID 19336503 DOI: 10.1210/Jc.2009-0354  0.396
2009 Lin MC, Lomo L, Baak JPA, Eng C, Ince TA, Crum CP, Mutter GL. Squamous morules are functionally inert elements of premalignant endometrial neoplasia Modern Pathology. 22: 167-174. PMID 19180120 DOI: 10.1038/Modpathol.2008.146  0.351
2008 Eng C. Cancer: A ringleader identified Nature. 455: 883-884. PMID 18923503 DOI: 10.1038/455883A  0.43
2008 Peczkowska M, Erlic Z, Hoffmann MM, Furmanek M, Cwikla J, Kubaszek A, Prejbisz A, Szutkowski Z, Kawecki A, Chojnowski K, Lewczuk A, Litwin M, Szyfter W, Walter MA, Sullivan M, ... Eng C, et al. Impact of screening kindreds for SDHD p.Cys11X as a common mutation associated with paraganglioma syndrome type 1. The Journal of Clinical Endocrinology and Metabolism. 93: 4818-25. PMID 18826997 DOI: 10.1210/Jc.2008-1290  0.467
2008 Orloff MS, Eng C. Genetic and phenotypic heterogeneity in the PTEN hamartoma tumour syndrome Oncogene. 27: 5387-5397. PMID 18794875 DOI: 10.1038/Onc.2008.237  0.413
2008 Milos IN, Frank-Raue K, Wohllk N, Maia AL, Pusiol E, Patocs A, Robledo M, Biarnes J, Barontini M, Links TP, de Groot JW, Dvorakova S, Peczkowska M, Rybicki LA, Sullivan M, ... ... Eng C, et al. Age-related neoplastic risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germ line RET Cys634Trp (TGC>TGG) mutation. Endocrine-Related Cancer. 15: 1035-41. PMID 18794325 DOI: 10.1677/Erc-08-0105  0.325
2008 Rigelsky CM, Jennings C, Lehtonen R, Minai OA, Eng C, Aldred MA. BMPR2 mutation in a patient with pulmonary arterial hypertension and suspected hereditary hemorrhagic telangiectasia American Journal of Medical Genetics Part A. 146: 2551-2556. PMID 18792970 DOI: 10.1002/Ajmg.A.32468  0.419
2008 Eng C. SDHB - A gene for all tumors? Journal of the National Cancer Institute. 100: 1193-1195. PMID 18728280 DOI: 10.1093/Jnci/Djn263  0.311
2008 Ni Y, Zbuk KM, Sadler T, Patocs A, Lobo G, Edelman E, Platzer P, Orloff MS, Waite KA, Eng C. Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes. American Journal of Human Genetics. 83: 261-8. PMID 18678321 DOI: 10.1016/J.Ajhg.2008.07.011  0.491
2008 Plon SE, Pirics ML, Nuchtern J, Hicks J, Russell H, Agrawal S, Zbuk K, Eng C, Hegde M, Chin EL. Multiple tumors in a child with germ-line mutations in TP53 and PTEN. The New England Journal of Medicine. 359: 537-9. PMID 18669439 DOI: 10.1056/Nejmc0800627  0.516
2008 Cho MY, Kim HS, Eng C, Kim DS, Kang SJ, Eom M, Yi SY, Bronner MP. First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity American Journal of Surgical Pathology. 32: 1258-1264. PMID 18594467 DOI: 10.1097/Pas.0B013E31816Be8B7  0.475
2008 Lobo GP, Waite KA, Planchon SM, Romigh T, Houghton JA, Eng C. ATP modulates PTEN subcellular localization in multiple cancer cell lines. Human Molecular Genetics. 17: 2877-85. PMID 18579579 DOI: 10.1093/Hmg/Ddn185  0.331
2008 Ahvenainen T, Lehtonen HJ, Lehtonen R, Vahteristo P, Aittomäki K, Baynam G, Dommering C, Eng C, Gruber SB, Grönberg H, Harvima R, Herva R, Hietala M, Kujala M, Kääriäinen H, et al. Mutation screening of fumarate hydratase by multiplex ligation-dependent probe amplification: detection of exonic deletion in a patient with leiomyomatosis and renal cell cancer Cancer Genetics and Cytogenetics. 183: 83-88. PMID 18503824 DOI: 10.1016/J.Cancergencyto.2008.01.010  0.485
2008 Pezzolesi MG, Platzer P, Waite KA, Eng C. Differential expression of PTEN-targeting microRNAs miR-19a and miR-21 in Cowden syndrome. American Journal of Human Genetics. 82: 1141-9. PMID 18460397 DOI: 10.1016/J.Ajhg.2008.04.005  0.355
2008 Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, Mecklin JP, Järvinen H, Eng C, Moeslein G, Shibata D, et al. Unregulated smooth-muscle myosin in human intestinal neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 105: 5513-8. PMID 18391202 DOI: 10.1073/Pnas.0801213105  0.438
2008 Weber F, Eng C. Update on the molecular diagnosis of endocrine tumors: Toward -omics-based personalized healthcare? Journal of Clinical Endocrinology and Metabolism. 93: 1097-1104. PMID 18390809 DOI: 10.1210/Jc.2008-0212  0.379
2008 Assié G, LaFramboise T, Platzer P, Eng C. Frequency of germline genomic homozygosity associated with cancer cases. Jama. 299: 1437-1445. PMID 18364486 DOI: 10.1001/Jama.299.12.1437  0.376
2008 Assié G, LaFramboise T, Platzer P, Bertherat J, Stratakis CA, Eng C. SNP arrays in heterogeneous tissue: highly accurate collection of both germline and somatic genetic information from unpaired single tumor samples. American Journal of Human Genetics. 82: 903-915. PMID 18355774 DOI: 10.1016/J.Ajhg.2008.01.012  0.316
2008 Trimboli AJ, Fukino K, de Bruin A, Wei G, Shen L, Tanner SM, Creasap N, Rosol TJ, Robinson ML, Eng C, Ostrowski MC, Leone G. Direct evidence for epithelial-mesenchymal transitions in breast cancer. Cancer Research. 68: 937-45. PMID 18245497 DOI: 10.1158/0008-5472.Can-07-2148  0.326
2008 Planchon SM, Waite KA, Eng C. The nuclear affairs of PTEN. Journal of Cell Science. 121: 249-253. PMID 18216329 DOI: 10.1242/Jcs.022459  0.374
2008 Peczkowska M, Cascon A, Prejbisz A, Kubaszek A, Cwikła BJ, Furmanek M, Erlic Z, Eng C, Januszewicz A, Neumann HPH. Extra-adrenal and adrenal pheochromocytomas associated with a germline SDHC mutation. Nature Clinical Practice Endocrinology & Metabolism. 4: 111-115. PMID 18212813 DOI: 10.1038/Ncpendmet0726  0.405
2008 Teresi RE, Planchon SM, Waite KA, Eng C. Regulation of the PTEN promoter by statins and SREBP. Human Molecular Genetics. 17: 919-28. PMID 18065496 DOI: 10.1093/Hmg/Ddm364  0.323
2008 Ji J, Eng C, Hemminki K. Familial risk for soft tissue tumors : A nation-wide epidemiological study from Sweden Journal of Cancer Research and Clinical Oncology. 134: 617-624. PMID 17929055 DOI: 10.1007/S00432-007-0327-5  0.328
2008 Pasini B, McWhinney SR, Bei T, Matyakhina L, Stergiopoulos S, Muchow M, Boikos SA, Ferrando B, Pacak K, Assie G, Baudin E, Chompret A, Ellison JW, Briere JJ, Rustin P, ... ... Eng C, et al. Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD. European Journal of Human Genetics : Ejhg. 16: 79-88. PMID 17667967 DOI: 10.1038/Sj.Ejhg.5201904  0.825
2008 Svensson P, Molander M, Eng C, Anvret M, Nordenskjöld A. Low frequency of RET mutations in Hirschsprung disease in Sweden Clinical Genetics. 54: 39-44. PMID 9727738 DOI: 10.1111/J.1399-0004.1998.Tb03691.X  0.384
2008 Markowitz J, Eng C, Sadee W, Heerema N, Li X, Campbell A, Culler K, O'Neil B, Lee R, Zalupski M, Dancey J, Grever M, Villalona-Calero M, Bekaii-Saab T. Abstract LB-306: A Phase II study of the efficacy and tolerability of Lapatinib in patients with advanced hepatocellular carcinomas. Cancer Research. 68. DOI: 10.1158/1538-7445.Am2008-Lb-306  0.361
2007 Patocs A, Zhang L, Xu Y, Weber F, Caldes T, Mutter GL, Platzer P, Eng C. Breast-cancer stromal cells with TP53 mutations and nodal metastases. The New England Journal of Medicine. 357: 2543-51. PMID 18094375 DOI: 10.1056/Nejmoa071825  0.495
2007 Zembowicz A, Knoepp SM, Bei T, Stergiopoulos S, Eng C, Mihm MC, Stratakis CA. Loss of expression of protein kinase A regulatory subunit 1α in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions The American Journal of Surgical Pathology. 31: 1764-1775. PMID 18059235 DOI: 10.1097/Pas.0B013E318057Faa7  0.346
2007 Cascon A, Landa I, Lopez-Jimenez E, Díez-Hernández A, Buchta M, Montero-Conde C, Leskelä S, Leandro-García LJ, Letón R, Rodríguez-Antona C, Eng C, Neumann HPH, Robledo M. Molecular characterisation of a common SDHB deletion in paraganglioma patients Journal of Medical Genetics. 45: 233-238. PMID 18057081 DOI: 10.1136/Jmg.2007.054965  0.475
2007 Heald B, Moran R, Milas M, Burke C, Eng C. Familial adenomatous polyposis in a patient with unexplained mental retardation. Nature Reviews Neurology. 3: 694-700. PMID 18046442 DOI: 10.1038/Ncpneuro0658  0.326
2007 Gustafson S, Zbuk KM, Scacheri C, Eng C. Cowden syndrome. Seminars in Oncology. 34: 428-34. PMID 17920899 DOI: 10.1053/j.seminoncol.2007.07.009  0.359
2007 Zbuk KM, Patocs A, Shealy A, Sylvester H, Miesfeldt S, Eng C. Germline mutations in PTEN and SDHC in a woman with epithelial thyroid cancer and carotid paraganglioma. Nature Clinical Practice. Oncology. 4: 608-12. PMID 17898811 DOI: 10.1038/Ncponc0935  0.496
2007 Neumann HPH, Vortmeyer A, Schmidt D, Werner M, Erlic Z, Cascon A, Bausch B, Januszewicz A, Eng C. Evidence of MEN-2 in the Original Description of Classic Pheochromocytoma The New England Journal of Medicine. 357: 1311-1315. PMID 17898100 DOI: 10.1056/Nejmoa071407  0.379
2007 Teresi RE, Zbuk KM, Pezzolesi MG, Waite KA, Eng C. Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation. American Journal of Human Genetics. 81: 756-67. PMID 17847000 DOI: 10.1086/521051  0.422
2007 Zbuk KM, Eng C. Hamartomatous polyposis syndromes Nature Clinical Practice Gastroenterology and Hepatology. 4: 492-502. PMID 17768394 DOI: 10.1038/Ncpgasthep0902  0.374
2007 Heald B, Hilden JM, Zbuk K, Norton A, Vyas P, Theil KS, Eng C. Severe TMD/AMKL with GATA1 mutation in a stillborn fetus with Down syndrome. Nature Clinical Practice. Oncology. 4: 433-8. PMID 17597708 DOI: 10.1038/Ncponc0876  0.377
2007 Ochs-Balcom HM, Falk G, Grady WM, Kinnard M, Willis J, Elston R, Eng C, Chak A. Consortium approach to identifying genes for Barrett's esophagus and esophageal adenocarcinoma. Translational Research : the Journal of Laboratory and Clinical Medicine. 150: 3-17. PMID 17585859 DOI: 10.1016/J.Trsl.2007.02.005  0.302
2007 Pinzone JJ, Eng C, Paik J, Brindle KA, Ringel MD, Katz JD. A novel PTEN mutation in Cowden syndrome is associated with a mixed degenerative-erosive arthritic process: potential molecular pathogenic mechanisms. American Journal of Medical Genetics. Part A. 143: 1522-7. PMID 17568419 DOI: 10.1002/Ajmg.A.31786  0.405
2007 Matyakhina L, Bei TA, McWhinney SR, Pasini B, Cameron S, Gunawan B, Stergiopoulos SG, Boikos S, Muchow M, Dutra A, Pak E, Campo E, Cid MC, Gomez F, Gaillard RC, ... ... Eng C, et al. Genetics of carney triad: recurrent losses at chromosome 1 but lack of germline mutations in genes associated with paragangliomas and gastrointestinal stromal tumors. The Journal of Clinical Endocrinology and Metabolism. 92: 2938-43. PMID 17535989 DOI: 10.1210/Jc.2007-0797  0.813
2007 Bennett KL, Hackanson B, Smith LT, Morrison CD, Lang JC, Schuller DE, Weber F, Eng C, Plass C. Tumor suppressor activity of CCAAT/enhancer binding protein alpha is epigenetically down-regulated in head and neck squamous cell carcinoma. Cancer Research. 67: 4657-64. PMID 17510391 DOI: 10.1158/0008-5472.Can-06-4793  0.318
2007 Fukino K, Shen L, Patocs A, Mutter GL, Eng C. Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma. Jama. 297: 2103-11. PMID 17507346 DOI: 10.1001/Jama.297.19.2103  0.33
2007 Bausch B, Borozdin W, Mautner VF, Hoffmann MM, Boehm D, Robledo M, Cascon A, Harenberg T, Schiavi F, Pawlu C, Peczkowska M, Letizia C, Calvieri S, Arnaldi G, Klingenberg-Noftz RD, ... ... Eng C, et al. Germline NF1 mutational spectra and loss-of-heterozygosity analyses in patients with pheochromocytoma and neurofibromatosis type 1. The Journal of Clinical Endocrinology and Metabolism. 92: 2784-92. PMID 17426081 DOI: 10.1210/Jc.2006-2833  0.804
2007 Alvarez-Breckenridge CA, Waite KA, Eng C. PTEN regulates phospholipase D and phospholipase C Human Molecular Genetics. 16: 1157-1163. PMID 17405772 DOI: 10.1093/Hmg/Ddm063  0.378
2007 Pezzolesi MG, Zbuk KM, Waite KA, Eng C. Comparative genomic and functional analyses reveal a novel cis-acting PTEN regulatory element as a highly conserved functional E-box motif deleted in Cowden syndrome. Human Molecular Genetics. 16: 1058-71. PMID 17341483 DOI: 10.1093/Hmg/Ddm053  0.4
2007 Wang Z, Yan P, Potter D, Eng C, Huang TH, Lin S. Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data. Bmc Bioinformatics. 8: 38. PMID 17270052 DOI: 10.1186/1471-2105-8-38  0.3
2007 Zbuk KM, Eng C. Predicting response to EGFR-tyrosine kinase inhibitors among diverse ancestries: Just 'way too polymorphic Cancer Biology and Therapy. 6: 112-115. PMID 17264670 DOI: 10.4161/Cbt.6.1.3787  0.305
2007 Kotsopoulos J, Lubinski J, Lynch HT, Klijn J, Ghadirian P, Neuhausen SL, Kim-Sing C, Foulkes WD, Moller P, Isaacs C, Domchek S, Randall S, Offit K, Tung N, Ainsworth P, ... ... Eng C, et al. Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment. 105: 221-8. PMID 17245541 DOI: 10.1007/S10549-006-9441-3  0.388
2007 Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 128: 157-70. PMID 17218262 DOI: 10.1016/J.Cell.2006.11.042  0.344
2007 Weber F, Xu Y, Zhang L, Patocs A, Shen L, Platzer P, Eng C. Microenvironmental genomic alterations and clinicopathological behavior in head and neck squamous cell carcinoma. Jama. 297: 187-95. PMID 17213402 DOI: 10.1001/Jama.297.2.187  0.328
2007 Yee LD, Williams N, Wen P, Young DC, Lester J, Johnson MV, Farrar WB, Walker MJ, Povoski SP, Suster S, Eng C. Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 246-52. PMID 17200362 DOI: 10.1158/1078-0432.Ccr-06-1947  0.318
2007 Zbuk KM, Eng C. Cancer phenomics: RET and PTEN as illustrative models Nature Reviews Cancer. 7: 35-45. PMID 17167516 DOI: 10.1038/Nrc2037  0.369
2007 Finch A, Beiner M, Lubinski J, Lynch HT, Moller P, Rosen B, Murphy J, Ghadirian P, Friedman E, Foulkes WD, Kim-Sing C, Wagner T, Tung N, Couch F, Stoppa-Lyonnet D, ... ... Eng C, et al. Salpingo-oophorectomy and the Risk of Ovarian, Fallopian Tube, and Peritoneal Cancers in Women with a BRCA1 or BRCA2 Mutation Obstetrical & Gynecological Survey. 62: 29-31. DOI: 10.1097/01.Ogx.0000251480.69322.50  0.428
2006 Bekaii-Saab T, Williams N, Plass C, Calero MV, Eng C. A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma. Bmc Cancer. 6: 278. PMID 17150109 DOI: 10.1186/1471-2407-6-278  0.376
2006 Yan PS, Venkataramu C, Ibrahim A, Liu JC, Shen RZ, Diaz NM, Centeno B, Weber F, Leu YW, Shapiro CL, Eng C, Yeatman TJ, Huang TH. Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 6626-36. PMID 17121881 DOI: 10.1158/1078-0432.Ccr-06-0467  0.327
2006 Ruiz-Ferrer M, Fernández RM, Antiñolo G, López-Alonso M, Eng C, Borrego S. A complex additive model of inheritance for Hirschsprung disease is supported by both RET mutations and predisposing RET haplotypes. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 8: 704-10. PMID 17108762 DOI: 10.1097/01.Gim.0000245632.06064.F1  0.447
2006 Bausch B, Boedeker CC, Berlis A, Brink I, Cybulla M, Walz MK, Januszewicz A, Letizia C, Opocher G, Eng C, Neumann HPH. Genetic and clinical investigation of pheochromocytoma: a 22-year experience, from Freiburg, Germany to international effort. Annals of the New York Academy of Sciences. 1073: 122-137. PMID 17102079 DOI: 10.1196/Annals.1353.013  0.449
2006 Pezzolesi MG, Li Y, Zhou XP, Pilarski R, Shen L, Eng C. Mutation-positive and mutation-negative patients with Cowden and Bannayan-Riley-Ruvalcaba syndromes associated with distinct 10q haplotypes. American Journal of Human Genetics. 79: 923-34. PMID 17033968 DOI: 10.1086/508943  0.506
2006 Chak A, Ochs-Balcom H, Falk G, Grady WM, Kinnard M, Willis JE, Elston R, Eng C. Familiality in Barrett's esophagus, adenocarcinoma of the esophagus, and adenocarcinoma of the gastroesophageal junction Cancer Epidemiology Biomarkers and Prevention. 15: 1668-1673. PMID 16985029 DOI: 10.1158/1055-9965.Epi-06-0293  0.318
2006 Chung JH, Ostrowski MC, Romigh T, Minaguchi T, Waite KA, Eng C. The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation. Human Molecular Genetics. 15: 2553-9. PMID 16849370 DOI: 10.1093/Hmg/Ddl177  0.314
2006 Finch A, Beiner M, Lubinski J, Lynch HT, Moller P, Rosen B, Murphy J, Ghadirian P, Friedman E, Foulkes WD, Kim-Sing C, Wagner T, Tung N, Couch F, Stoppa-Lyonnet D, ... ... Eng C, et al. Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation. Jama. 296: 185-92. PMID 16835424 DOI: 10.1001/Jama.296.2.185  0.399
2006 Bausch B, Koschker AC, Fassnacht M, Stoevesandt J, Hoffmann MM, Eng C, Allolio B, Neumann HPH. Comprehensive Mutation Scanning of NF1 in Apparently Sporadic Cases of Pheochromocytoma The Journal of Clinical Endocrinology and Metabolism. 91: 3478-3481. PMID 16787982 DOI: 10.1210/Jc.2006-0780  0.446
2006 Sarquis MS, Agrawal S, Shen L, Pilarski R, Zhou XP, Eng C. Distinct expression profiles for PTEN transcript and its splice variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. American Journal of Human Genetics. 79: 23-30. PMID 16773562 DOI: 10.1086/504392  0.437
2006 Tekin M, Hişmi BÖ, Fitoz S, Yalçinkaya F, Ekim M, Kansu A, Ertem M, Deda G, Tutar E, Arsan S, Zhou XP, Pilarski R, Eng C, Akar N. A germline PTEN mutation with manifestations of prenatal onset and verrucous epidermal nevus American Journal of Medical Genetics Part A. 140: 1472-1475. PMID 16752378 DOI: 10.1002/Ajmg.A.31273  0.44
2006 Kokko A, Laiho P, Lehtonen R, Korja S, Carvajal-Carmona LG, Järvinen H, Mecklin JP, Eng C, Schleutker J, Tomlinson IPM, Vahteristo P, Aaltonen LA. EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis Bmc Cancer. 6: 145-145. PMID 16740153 DOI: 10.1186/1471-2407-6-145  0.418
2006 Delnatte C, Sanlaville D, Mougenot JF, Vermeesch JR, Houdayer C, Blois MCD, Genevieve D, Goulet O, Fryns JP, Jaubert F, Vekemans M, Lyonnet S, Romana S, Eng C, Stoppa-Lyonnet D. Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes. American Journal of Human Genetics. 78: 1066-1074. PMID 16685657 DOI: 10.1086/504301  0.355
2006 Weber F, Shen L, Fukino K, Patocs A, Mutter GL, Caldes T, Eng C. Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation. American Journal of Human Genetics. 78: 961-72. PMID 16685647 DOI: 10.1086/504090  0.356
2006 Lim LC, Tan MH, Eng C, Teh BT, Rajasoorya RC. Thymic carcinoid in multiple endocrine neoplasia 1: genotype–phenotype correlation and prevention Journal of Internal Medicine. 259: 428-432. PMID 16594911 DOI: 10.1111/J.1365-2796.2006.01619.X  0.448
2006 Friedman E, Kotsopoulos J, Lubinski J, Lynch HT, Ghadirian P, Neuhausen SL, Isaacs C, Weber B, Foulkes WD, Moller P, Rosen B, Kim-Sing C, Gershoni-Baruch R, Ainsworth P, Daly M, ... ... Eng C, et al. Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers. Breast Cancer Research : Bcr. 8: R15. PMID 16563180 DOI: 10.1186/Bcr1387  0.398
2006 Agrawal S, Eng C. Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer Human Molecular Genetics. 15: 777-787. PMID 16436456 DOI: 10.1093/Hmg/Ddi492  0.358
2006 Teresi RE, Shaiu CW, Chen CS, Chatterjee VK, Waite KA, Eng C. Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone. International Journal of Cancer. 118: 2390-8. PMID 16425225 DOI: 10.1002/Ijc.21799  0.361
2006 Tang Y, Eng C. PTEN autoregulates its expression by stabilization of p53 in a phosphatase-independent manner Cancer Research. 66: 736-742. PMID 16424003 DOI: 10.1158/0008-5472.Can-05-1557  0.454
2006 Patterson AR, Leitch AM, Weatherall P, Zhou XP, Eng C, Tomlinson GE. Case 4. Fibrocystic breast disease in a 16-year-old female with PTEN hamartoma tumor syndrome Journal of Clinical Oncology. 24: 525-527. PMID 16421431 DOI: 10.1200/Jco.2004.01.0447  0.315
2006 Abdel-Rahman MH, Yang Y, Zhou XP, Craig EL, Davidorf FH, Eng C. High frequency of submicroscopic hemizygous deletion is a major mechanism of loss of expression of PTEN in uveal melanoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 288-95. PMID 16344319 DOI: 10.1200/Jco.2005.02.2418  0.373
2006 Perry CG, Young WF, McWhinney SR, Bei T, Stergiopoulos S, Knudson RA, Ketterling RP, Eng C, Stratakis CA, Carney JA. Functioning paraganglioma and gastrointestinal stromal tumor of the jejunum in three women: syndrome or coincidence. The American Journal of Surgical Pathology. 30: 42-9. PMID 16330941 DOI: 10.1097/01.Pas.0000178087.69394.9F  0.801
2006 Sarquis MS, Weber F, Shen L, Broelsch CE, Jhiang SM, Zedenius J, Frilling A, Eng C. High frequency of loss of heterozygosity in imprinted, compared with nonimprinted, genomic regions in follicular thyroid carcinomas and atypical adenomas. The Journal of Clinical Endocrinology and Metabolism. 91: 262-9. PMID 16249278 DOI: 10.1210/Jc.2005-1880  0.334
2006 Takahashi M, Yang XJ, McWhinney S, Sano N, Eng C, Kagawa S, Teh BT, Kanayama HO. cDNA microarray analysis assists in diagnosis of malignant intrarenal pheochromocytoma originally masquerading as a renal cell carcinoma. Journal of Medical Genetics. 42: e48. PMID 16061554 DOI: 10.1136/Jmg.2005.031708  0.789
2006 Nkondjock A, Ghadirian P, Kotsopoulos J, Lubinski J, Lynch H, Kim-Sing C, Horsman D, Rosen B, Isaacs C, Weber B, Foulkes W, Ainsworth P, Tung N, Eisen A, Friedman E, ... Eng C, et al. Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. International Journal of Cancer. 118: 103-7. PMID 16032702 DOI: 10.1002/Ijc.21296  0.377
2006 Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. Journal of Medical Genetics. 42: 318-21. PMID 15805158 DOI: 10.1136/jmg.2004.024646  0.367
2006 Sanlaville D, Delnatte C, Mougenot JF, Vermeesch JR, Houdayer C, Blois MCD, Genevieve D, Goulet O, Fryns JP, Jaubert F, Vekemans M, Lyonnet S, Romana S, Eng C, Stoppa-Lyonnet D. Reply to Salviati et al. American Journal of Human Genetics. 79: 596-597. DOI: 10.1086/507152  0.376
2005 Bekaii-Saab TS, Sawada T, Williams N, Frankel W, Plass C, Villalona-Calero M, Eng C. Intragenic EGFR and EGFR2 mutations in hepatobiliary tumors and potential role in predicting response to agents that target EGFR. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 4037. PMID 27944143 DOI: 10.1200/Jco.2005.23.16_Suppl.4037  0.373
2005 Eng C, Weber F. Gene-expression profiling in differentiated thyroid cancer - A viable strategy for the practice of genomic medicine? Future Oncology. 1: 497-510. PMID 16556026 DOI: 10.2217/14796694.1.4.497  0.344
2005 Bermejo JL, Eng C, Hemminki K. Cancer characteristics in Swedish families fulfilling criteria for hereditary nonpolyposis colorectal cancer. Gastroenterology. 129: 1889-1899. PMID 16344057 DOI: 10.1053/J.Gastro.2005.09.012  0.36
2005 Sweet K, Willis J, Zhou XP, Gallione C, Sawada T, Alhopuro P, Khoo SK, Patocs A, Martin C, Bridgeman S, Heinz J, Pilarski R, Lehtonen R, Prior TW, Frebourg T, ... ... Eng C, et al. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. Jama. 294: 2465-73. PMID 16287957 DOI: 10.1001/Jama.294.19.2465  0.3
2005 Schiavi F, Boedeker CC, Bausch B, Peçzkowska M, Gomez CF, Strassburg T, Pawlu C, Buchta M, Salzmann M, Hoffmann MM, Berlis A, Brink I, Cybulla M, Muresan M, Walter MA, ... ... Eng C, et al. Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene. Jama. 294: 2057-63. PMID 16249420 DOI: 10.1001/Jama.294.16.2057  0.499
2005 Marsee DK, Vadysirisack DD, Morrison CD, Prasad ML, Eng C, Duh QY, Rauen KA, Kloos RT, Jhiang SM. Variable expression of coxsackie-adenovirus receptor in thyroid tumors: implications for adenoviral gene therapy. Thyroid : Official Journal of the American Thyroid Association. 15: 977-87. PMID 16187905 DOI: 10.1089/Thy.2005.15.977  0.321
2005 Chung JH, Eng C. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis Cancer Research. 65: 8096-8100. PMID 16166282 DOI: 10.1158/0008-5472.Can-05-1888  0.314
2005 Eng C. High frequency of large gene deletions and rearrangements in Lynch syndrome-back to the future? Gastroenterology. 129: 1124-1126. PMID 16143150 DOI: 10.1053/J.Gastro.2005.07.043  0.319
2005 Weber F, Fukino K, Villalona-Calero M, Eng C. Limitations of Single-Strand Conformation Polymorphism Analysis As a High-Throughput Method for the Detection of EGFR Mutations in the Clinical Setting Journal of Clinical Oncology. 23: 5847-5848. PMID 16110042 DOI: 10.1200/Jco.2005.01.5222  0.353
2005 Dourisboure RJ, Belli S, Domenichini E, Podestá EJ, Eng C, Solano AR. Penetrance and Clinical Manifestations of Non-Hotspot Germline RET Mutation, C630R, in a Family with Medullary Thyroid Carcinoma Thyroid. 15: 668-671. PMID 16053382 DOI: 10.1089/Thy.2005.15.668  0.474
2005 Hemminki K, Eng C, Chen B. Familial Risks for Nonmedullary Thyroid Cancer The Journal of Clinical Endocrinology and Metabolism. 90: 5747-5753. PMID 16030170 DOI: 10.1210/Jc.2005-0935  0.357
2005 Agrawal S, Pilarski R, Eng C. Different splicing defects lead to differential effects downstream of the lipid and protein phosphatase activities of PTEN Human Molecular Genetics. 14: 2459-2468. PMID 16014636 DOI: 10.1093/Hmg/Ddi246  0.485
2005 Chung JH, Ginn-Pease ME, Eng C. Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Has Nuclear Localization Signal–Like Sequences for Nuclear Import Mediated by Major Vault Protein Cancer Research. 65: 4108-4116. PMID 15899801 DOI: 10.1158/0008-5472.Can-05-0124  0.303
2005 Weber F, Fukino K, Sawada T, Williams N, Sweet K, Brena RM, Plass C, Caldes T, Mutter GL, Villalona-Calero MA, Eng C. Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors British Journal of Cancer. 92: 1922-1926. PMID 15841079 DOI: 10.1038/Sj.Bjc.6602557  0.415
2005 Waite KA, Sinden MR, Eng C. Phytoestrogen exposure elevates PTEN levels Human Molecular Genetics. 14: 1457-1463. PMID 15829497 DOI: 10.1093/Hmg/Ddi155  0.327
2005 Fernandez RM, Boru G, Peciña A, Jones K, López-Alonso M, Antiñolo G, Borrego S, Eng C. Ancestral RET haplotype associated with Hirschsprung's disease shows linkage disequilibrium breakpoint at -1249. Journal of Medical Genetics. 42: 322-7. PMID 15805159 DOI: 10.1136/Jmg.2004.023960  0.36
2005 Weber F, Shen L, Aldred MA, Morrison CD, Frilling A, Saji M, Schuppert F, Broelsch CE, Ringel MD, Eng C. Genetic classification of benign and malignant thyroid follicular neoplasia based on a three-gene combination. The Journal of Clinical Endocrinology and Metabolism. 90: 2512-21. PMID 15713710 DOI: 10.1210/Jc.2004-2028  0.334
2005 Eng C. Molecular Basis of Thyroid Cancer Thyroid. 15: 1109-1109. DOI: 10.1089/Thy.2005.15.1109  0.31
2004 Weber F, Aldred MA, Morrison CD, Plass C, Frilling A, Broelsch CE, Waite KA, Eng C. Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis. The Journal of Clinical Endocrinology and Metabolism. 90: 1149-55. PMID 15546898 DOI: 10.1210/Jc.2004-1447  0.365
2004 McWhinney SR, Pilarski RT, Forrester SR, Schneider MC, Sarquis MM, Dias EP, Eng C. Large germline deletions of mitochondrial complex II subunits SDHB and SDHD in hereditary paraganglioma. The Journal of Clinical Endocrinology and Metabolism. 89: 5694-9. PMID 15531530 DOI: 10.1210/Jc.2004-0769  0.823
2004 Hemminki K, Eng C. Clinical genetic counselling for familial cancers requires reliable data on familial cancer risks and general action plans Journal of Medical Genetics. 41: 801-807. PMID 15520403 DOI: 10.1136/Jmg.2004.022731  0.348
2004 Astuti D, Morris M, Krona C, Abel F, Gentle D, Martinsson T, Kogner P, Neumann HPH, Voutilainen R, Eng C, Rustin P, Latif F, Maher ER. Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma. British Journal of Cancer. 91: 1835-1841. PMID 15505628 DOI: 10.1038/Sj.Bjc.6602202  0.433
2004 Fukino K, Shen L, Matsumoto S, Morrison CD, Mutter GL, Eng C. Combined Total Genome Loss of Heterozygosity Scan of Breast Cancer Stroma and Epithelium Reveals Multiplicity of Stromal Targets Cancer Research. 64: 7231-7236. PMID 15492239 DOI: 10.1158/0008-5472.Can-04-2866  0.4
2004 Neumann HP, Pawlu C, Peczkowska M, Bausch B, McWhinney SR, Muresan M, Buchta M, Franke G, Klisch J, Bley TA, Hoegerle S, Boedeker CC, Opocher G, Schipper J, Januszewicz A, ... Eng C, et al. Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. Jama. 292: 943-51. PMID 15328326 DOI: 10.1001/Jama.292.8.943  0.834
2004 Nagy R, Sweet K, Eng C. Highly penetrant hereditary cancer syndromes. Oncogene. 23: 6445-6470. PMID 15322516 DOI: 10.1038/Sj.Onc.1207714  0.4
2004 Morrison C, Farrar W, Kneile J, Williams N, Liu-Stratton Y, Bakaletz A, Aldred MA, Eng C. Molecular Classification of Parathyroid Neoplasia by Gene Expression Profiling American Journal of Pathology. 165: 565-576. PMID 15277230 DOI: 10.1016/S0002-9440(10)63321-4  0.343
2004 Aldred MA, Sanford ROC, Thomas NS, Barrow MA, Wilson LC, Brueton LA, Bonaglia MC, Hennekam RCM, Eng C, Dennis NR, Trembath RC. Molecular analysis of 20 patients with 2q37.3 monosomy: Definition of minimum deletion intervals for key phenotypes Journal of Medical Genetics. 41: 433-439. PMID 15173228 DOI: 10.1136/Jmg.2003.017202  0.34
2004 Oktenli C, Gul D, Deveci MS, Saglam M, Upadhyaya M, Thompson P, Consoli C, Kocar IH, Pilarski R, Zhou XP, Eng C. Unusual features in a patient with neurofibromatosis type 1: multiple subcutaneous lipomas, a juvenile polyp in ascending colon, congenital intrahepatic portosystemic venous shunt, and horseshoe kidney. American Journal of Medical Genetics Part A. 127: 298-301. PMID 15150783 DOI: 10.1002/Ajmg.A.30008  0.4
2004 Fernandez RM, Robledo M, Antinolo G, Pecina A, Ruiz-Llorente S, Eng C, Borrego S. The RET IVS1-126G>T variant is strongly associated with the development of sporadic medullary thyroid cancer. Thyroid : Official Journal of the American Thyroid Association. 14: 329-31. PMID 15142370 DOI: 10.1089/105072504323031022  0.309
2004 Pilarski R, Eng C. Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome Journal of Medical Genetics. 41: 323-326. PMID 15121767 DOI: 10.1136/Jmg.2004.018036  0.434
2004 Hampel H, Sweet K, Westman JA, Offit K, Eng C. Referral for cancer genetics consultation: a review and compilation of risk assessment criteria Journal of Medical Genetics. 41: 81-91. PMID 14757853 DOI: 10.1136/Jmg.2003.010918  0.339
2004 Nassif NT, Lobo GP, Wu X, Henderson CJ, Morrison CD, Eng C, Jalaludin B, Segelov E. PTEN mutations are common in sporadic microsatellite stable colorectal cancer. Oncogene. 23: 617-28. PMID 14724591 DOI: 10.1038/Sj.Onc.1207059  0.476
2004 Lehtonen R, Kiuru MH, Vanharanta S, Sjöberg J, Aaltonen LM, Aittomäki K, Arola J, Butzow R, Eng C, Husgafvel-Pursiainen K, Isola J, Järvinen H, Koivisto P, Mecklin JP, Peltomäki P, et al. Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. American Journal of Pathology. 164: 17-22. PMID 14695314 DOI: 10.1016/S0002-9440(10)63091-X  0.498
2004 Vanharanta S, Buchta M, McWhinney SR, Virta SK, Peçzkowska M, Morrison CD, Lehtonen R, Januszewicz A, Järvinen H, Juhola M, Mecklin JP, Pukkala E, Herva R, Kiuru M, Nupponen NN, ... ... Eng C, et al. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. American Journal of Human Genetics. 74: 153-9. PMID 14685938 DOI: 10.1086/381054  0.826
2004 Peczkowska M, Buchta M, Me Whinney SR, Janaszek-Sitkowska H, Kabat M, Januszewicz M, Prejbisz A, Eng C, Neumann HP, Januszewicz A. HEREDITARY PHEOCHROMOCYTOMA ASSOCIATED WITH SDHB GENE GERMLINE MUTATION Journal of Hypertension. 22: S75. DOI: 10.1097/00004872-200406002-00255  0.344
2004 Neumann H, Bausch B, McWhinney S, Bender B, Gimm O, Franke G, Schipper J, Klisch J, Altehoefer C, Zerres K, Januszewicz A, Eng C. Germline Mutations in Non-syndromic Pheochromocytoma Hormone and Metabolic Research. 36. DOI: 10.1055/S-2004-830835  0.438
2003 Astuti D, Hart-Holden N, Latif F, Lalloo F, Black GC, Lim C, Moran A, Grossman AB, Hodgson SV, Freemont A, Ramsden R, Eng C, Evans DG, Maher ER. Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility. Clinical Endocrinology. 59: 728-33. PMID 14974914 DOI: 10.1046/J.1365-2265.2003.01914.X  0.304
2003 Zhou XP, Marsh DJ, Morrison CD, Chaudhury AR, Maxwell M, Reifenberger G, Eng C. Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults American Journal of Human Genetics. 73: 1191-1198. PMID 14566704 DOI: 10.1086/379382  0.467
2003 McWhinney SR, Boru G, Binkley PK, Peczkowska M, Januszewicz AA, Neumann HP, Eng C. Intronic single nucleotide polymorphisms in the RET protooncogene are associated with a subset of apparently sporadic pheochromocytoma and may modulate age of onset. The Journal of Clinical Endocrinology and Metabolism. 88: 4911-6. PMID 14557473 DOI: 10.1210/Jc.2003-030245  0.804
2003 Waite KA, Eng C. From developmental disorder to heritable cancer: It's all in the BMP/TGF-β family Nature Reviews Genetics. 4: 763-773. PMID 14526373 DOI: 10.1038/Nrg1178  0.37
2003 Eng C. Constipation, polyps, or cancer? Let PTEN predict your future American Journal of Medical Genetics. 122: 315-322. PMID 14518069 DOI: 10.1002/Ajmg.A.20477  0.485
2003 Fernández RM, Antiñolo G, Eng C, Borrego S. The RET C620S mutation causes multiple endocrine neoplasia type 2A (MEN2A) but not Hirschsprung disease (HSCR) in a family cosegregating both phenotypes. Human Mutation. 22: 412-5. PMID 14517954 DOI: 10.1002/Humu.10273  0.388
2003 Drovdlic CM, Goddard KA, Chak A, Brock W, Chessler L, King JF, Richter J, Falk GW, Johnston DK, Fisher JL, Grady WM, Lemeshow S, Eng C. Demographic and phenotypic features of 70 families segregating Barrett's oesophagus and oesophageal adenocarcinoma. Journal of Medical Genetics. 40: 651-6. PMID 12960209 DOI: 10.1136/Jmg.40.9.651  0.397
2003 Eng C. PTEN: One gene, Many syndromes Human Mutation. 22: 183-198. PMID 12938083 DOI: 10.1002/Humu.10257  0.507
2003 Delatycki M, Danks A, Churchyard A, Zhou X, Eng C. De novo germline PTEN mutation in a man with Lhermitte-Duclos disease which arose on the paternal chromosome and was transmitted to his child with polydactyly and Wormian bones Journal of Medical Genetics. 40. PMID 12920084 DOI: 10.1136/Jmg.40.8.E92  0.479
2003 Dallol A, Krex D, Hesson L, Eng C, Maher ER, Latif F. Frequent epigenetic inactivation of the SLIT2 gene in gliomas. Oncogene. 22: 4611-4616. PMID 12881718 DOI: 10.1038/Sj.Onc.1206687  0.336
2003 Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, ... Eng C, et al. Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway. American Journal of Human Genetics. 73: 404-11. PMID 12844284 DOI: 10.1086/377109  0.481
2003 McGarrity TJ, Wagner Baker MJ, Ruggiero FM, Thiboutot DM, Hampel H, Zhou XP, Eng C. GI polyposis and glycogenic acanthosis of the esophagus associated with PTEN mutation positive Cowden syndrome in the absence of cutaneous manifestations. The American Journal of Gastroenterology. 98: 1429-34. PMID 12818292 DOI: 10.1111/J.1572-0241.2003.07496.X  0.484
2003 Aldred MA, Morrison C, Gimm O, Hoang-Vu C, Krause U, Dralle H, Jhiang S, Eng C. Peroxisome proliferator-activated receptor gamma is frequently downregulated in a diversity of sporadic nonmedullary thyroid carcinomas. Oncogene. 22: 3412-6. PMID 12776192 DOI: 10.1038/Sj.Onc.1206400  0.327
2003 Jaeger EE, Woodford-Richens KL, Lockett M, Rowan AJ, Sawyer EJ, Heinimann K, Rozen P, Murday VA, Whitelaw SC, Ginsberg A, Atkin WS, Lynch HT, Southey MC, Debinski H, Eng C, et al. An ancestral Ashkenazi haplotype at the HMPS/CRAC1 locus on 15q13-q14 is associated with hereditary mixed polyposis syndrome. American Journal of Human Genetics. 72: 1261-7. PMID 12696020 DOI: 10.1086/375144  0.327
2003 Borrego S, Fernández RM, Dziema H, Niess A, López-Alonso M, Antiñolo G, Eng C. Investigation of germline GFRA4 mutations and evaluation of the involvement of GFRA1, GFRA2, GFRA3, and GFRA4 sequence variants in Hirschsprung disease. Journal of Medical Genetics. 40: e18. PMID 12624147 DOI: 10.1136/Jmg.40.3.E18  0.461
2003 Eng C, Kiuru M, Fernandez MJ, Aaltonen LA. A role for mitochondrial enzymes in inherited neoplasia and beyond. Nature Reviews. Cancer. 3: 193-202. PMID 12612654 DOI: 10.1038/Nrc1013  0.399
2003 Gupta RA, Sarraf P, Mueller E, Brockman JA, Prusakiewicz JJ, Eng C, Willson TM, DuBois RN. Peroxisome proliferator-activated receptor gamma-mediated differentiation: a mutation in colon cancer cells reveals divergent and cell type-specific mechanisms. The Journal of Biological Chemistry. 278: 22669-77. PMID 12591919 DOI: 10.1074/Jbc.M300637200  0.349
2003 Borrego S, Wright FA, Fernández RM, Williams N, López-Alonso M, Davuluri R, Antiñolo G, Eng C. A founding locus within the RET proto-oncogene may account for a large proportion of apparently sporadic Hirschsprung disease and a subset of cases of sporadic medullary thyroid carcinoma. American Journal of Human Genetics. 72: 88-100. PMID 12474140 DOI: 10.1086/345466  0.403
2003 Waite KA, Eng C. BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels Human Molecular Genetics. 12: 679-684. DOI: 10.1093/Hmg/Ddg069  0.391
2003 Drovdlic CM, Goddard KAB, Chak A, Brock W, Chessler L, King J, Richter J, Falk GW, Johnston KD, Grady WM, Eng C. Demographic and phenotypic features of 65 families segregating Barrett esophagus and esophageal adenocarcinoma Gastroenterology. 124. DOI: 10.1016/S0016-5085(03)82774-9  0.313
2002 Borrego S, Fernández RM, Dziema H, Japón MA, Marcos I, Eng C, Antiñolo G. Evaluation of germline sequence variants of GFRA1, GFRA2, and GFRA3 genes in a cohort of Spanish patients with sporadic medullary thyroid cancer. Thyroid : Official Journal of the American Thyroid Association. 12: 1017-22. PMID 12490080 DOI: 10.1089/105072502320908367  0.453
2002 Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nature Genetics. 32: 355-7. PMID 12379854 DOI: 10.1038/Ng1013  0.427
2002 Maher ER, Eng C. The pressure rises: Update on the genetics of phaeochromocytoma Human Molecular Genetics. 11: 2347-2354. PMID 12351569 DOI: 10.1093/Hmg/11.20.2347  0.47
2002 Frisk T, Foukakis T, Dwight T, Lundberg J, Höög A, Wallin G, Eng C, Zedenius J, Larsson C. Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer. Genes, Chromosomes & Cancer. 35: 74-80. PMID 12203792 DOI: 10.1002/Gcc.10098  0.468
2002 Zhou XP, Loukola A, Salovaara R, Nystrom-Lahti M, Peltomäki P, Chapelle ADl, Aaltonen LA, Eng C. PTEN Mutational Spectra, Expression Levels, and Subcellular Localization in Microsatellite Stable and Unstable Colorectal Cancers American Journal of Pathology. 161: 439-447. PMID 12163369 DOI: 10.1016/S0002-9440(10)64200-9  0.483
2002 Eng C. Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis Annals of the New York Academy of Sciences. 968: 213-221. PMID 12119278 DOI: 10.1111/J.1749-6632.2002.Tb04337.X  0.471
2002 Neumann HP, Bausch B, McWhinney SR, Bender BU, Gimm O, Franke G, Schipper J, Klisch J, Altehoefer C, Zerres K, Januszewicz A, Eng C, Smith WM, Munk R, Manz T, ... ... Eng C, et al. Germ-line mutations in nonsyndromic pheochromocytoma. The New England Journal of Medicine. 346: 1459-66. PMID 12000816 DOI: 10.1056/Nejmoa020152  0.819
2002 Zhou XP, Hampel H, Roggenbuck J, Saba N, Prior TW, Eng C. A 39-bp Deletion Polymorphism in PTEN in African American Individuals: Implications for Molecular Diagnostic Testing The Journal of Molecular Diagnostics. 4: 114-117. PMID 11986403 DOI: 10.1016/S1525-1578(10)60690-3  0.499
2002 Humar B, Toro T, Graziano F, Müller H, Dobbie Z, Kwang-Yang H, Eng C, Hampel H, Gilbert D, Winship I, Parry S, Ward R, Findlay M, Christian A, Tucker M, et al. Novel germline CDH1 mutations in hereditary diffuse gastric cancer families. Human Mutation. 19: 518-25. PMID 11968084 DOI: 10.1002/Humu.10067  0.468
2002 Whiteman DC, Zhou XP, Cummings MC, Pavey S, Hayward NK, Eng C. Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma International Journal of Cancer. 99: 63-67. PMID 11948493 DOI: 10.1002/Ijc.10294  0.378
2002 Caldes T, Godino J, Hoya Mdl, Carbonero IG, Segura PP, Eng C, Benito M, Diaz-Rubio E. Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain. International Journal of Cancer. 98: 774-779. PMID 11920650 DOI: 10.1002/Ijc.10240  0.494
2002 Waite KA, Eng C. Protean PTEN: Form and function American Journal of Human Genetics. 70: 829-844. PMID 11875759 DOI: 10.1086/340026  0.418
2002 Zhou XP, Kuismanen S, Nystrom-Lahti M, Peltomaki P, Eng C. Distinct PTEN mutational spectra in hereditary non-polyposis colon cancer syndrome-related endometrial carcinomas compared to sporadic microsatellite unstable tumors Human Molecular Genetics. 11: 445-450. PMID 11854177 DOI: 10.1093/Hmg/11.4.445  0.529
2002 Stratakis CA, Miller WR, Severin E, Chin KV, Bertherat J, Amieux PS, Eng C, Kammer GM, Dumont JE, Tortora G, Beaven MA, Puck TT, Jan de Beur SM, Weistein LS, Cho-Chung YS. Protein-kinase a and human disease: The core of cAMP-dependent signaling in health and disease Hormone and Metabolic Research. 34: 169-175. DOI: 10.1055/S-2002-26710  0.315
2001 Eng C, Thiele H, Zhou XP, Gorlin RJ, Hennekam RC, Winter RM. PTEN mutations and proteus syndrome. Lancet. 358: 2079-80. PMID 11755639 DOI: 10.1016/S0140-6736(01)07110-0  0.443
2001 Huang Y, Prasad M, Lemon WJ, Hampel H, Wright FA, Kornacker K, LiVolsi V, Frankel W, Kloos RT, Eng C, Pellegata NS, de la Chapelle A. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proceedings of the National Academy of Sciences of the United States of America. 98: 15044-9. PMID 11752453 DOI: 10.1073/Pnas.251547398  0.351
2001 Eng C, Brody LC, Wagner TM, Devilee P, Vijg J, Szabo C, Tavtigian SV, Nathanson KL, Ostrander E, Frank TS. Interpreting epidemiological research: blinded comparison of methods used to estimate the prevalence of inherited mutations in BRCA1. Journal of Medical Genetics. 38: 824-33. PMID 11748305 DOI: 10.1136/Jmg.38.12.824  0.461
2001 Reardon W, Zhou X, Eng C. A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association. Journal of Medical Genetics. 38: 820-823. PMID 11748304 DOI: 10.1136/Jmg.38.12.820  0.485
2001 Astuti D, Agathanggelou A, Honorio S, Dallol A, Martinsson T, Kogner P, Cummins C, Neumann HPH, Voutilainen R, Dahia PL, Eng C, Maher ER, Latif F. RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours. Oncogene. 20: 7573-7577. PMID 11709729 DOI: 10.1038/Sj.Onc.1204968  0.352
2001 Ruiz A, Antiñolo G, Fernández RM, Eng C, Marcos I, Borrego S. Germline sequence variant S836S in the RET proto-oncogene is associated with low level predisposition to sporadic medullary thyroid carcinoma in the Spanish population. Clinical Endocrinology. 55: 399-402. PMID 11589684 DOI: 10.1046/J.1365-2265.2001.01328.X  0.459
2001 Kurose K, Hoshaw-Woodard S, Adeyinka A, Lemeshow S, Watson PH, Eng C. Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: Clues to tumour-microenvironment interactions Human Molecular Genetics. 10: 1907-1913. PMID 11555627 DOI: 10.1093/Hmg/10.18.1907  0.321
2001 Zhou XP, Woodford-Richens K, Lehtonen R, Kurose K, Aldred M, Hampel H, Launonen V, Virta S, Pilarski R, Salovaara R, Bodmer WF, Conrad BA, Dunlop M, Hodgson SV, Iwama T, ... ... Eng C, et al. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. American Journal of Human Genetics. 69: 704-11. PMID 11536076 DOI: 10.1086/323703  0.484
2001 Smith WM, Zhou XP, Kurose K, Gao X, Latif F, Kroll T, Sugano K, Cannistra SA, Clinton SK, Maher ER, Prior TW, Eng C. Opposite association of two PPARG variants with cancer: overrepresentation of H449H in endometrial carcinoma cases and underrepresentation of P12A in renal cell carcinoma cases. Human Genetics. 109: 146-51. PMID 11511919 DOI: 10.1007/S004390100563  0.401
2001 Marsh DJ, Theodosopoulos G, Howell V, Richardson AL, Benn DE, Proos AL, Eng C, Robinson BG. Rapid mutation scanning of genes associated with familial cancer syndromes using denaturing high-performance liquid chromatography Neoplasia. 3: 236-244. PMID 11494117 DOI: 10.1038/Sj.Neo.7900154  0.522
2001 Bender BU, Eng C, Olschewski M, Berger DP, Laubenberger J, Altehöfer C, Kirste G, Orszagh M, Velthoven Vv, Miosczka H, Schmidt D, Neumann HPH. VHL c.505 T>C mutation confers a high age related penetrance but no increased overall mortality Journal of Medical Genetics. 38: 508-514. PMID 11483638 DOI: 10.1136/Jmg.38.8.508  0.37
2001 Zhou X, Hampel H, Thiele H, Gorlin RJ, Hennekam RC, Parisi M, Winter RM, Eng C. Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes. Lancet. 358: 210-1. PMID 11476841 DOI: 10.1016/S0140-6736(01)05412-5  0.473
2001 Smiraglia DJ, Rush LJ, Frühwald MC, Dai Z, Held WA, Costello JF, Lang JC, Eng C, Li B, Wright FA, Caligiuri MA, Plass C. Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies Human Molecular Genetics. 10: 1413-1419. PMID 11440994 DOI: 10.1093/Hmg/10.13.1413  0.333
2001 Vanhorne JB, Gimm O, Myers SM, Kaushik A, von Deimling A, Eng C, Mulligan LM. Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease. Human Genetics. 108: 409-15. PMID 11409869 DOI: 10.1007/S004390100506  0.368
2001 Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E, Sköldberg F, Husebye ES, Eng C, Maher ER. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. American Journal of Human Genetics. 69: 49-54. PMID 11404820 DOI: 10.1086/321282  0.487
2001 Kurose K, Zhou XP, Araki T, Cannistra SA, Maher ER, Eng C. Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas. American Journal of Pathology. 158: 2097-2106. PMID 11395387 DOI: 10.1016/S0002-9440(10)64681-0  0.447
2001 Eng C. To be or not to BMP Nature Genetics. 28: 105-107. PMID 11381248 DOI: 10.1038/88802  0.349
2001 Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C. Over-representation of a germline variant in the gene encoding RET co-receptor GFRα-1 but not GFRα-2 or GFRα-3 in cases with sporadic medullary thyroid carcinoma Oncogene. 20: 2161-2170. PMID 11360200 DOI: 10.1038/Sj.Onc.1204289  0.319
2001 Parisi MA, Dinulos MB, Leppig KA, Sybert VP, Eng C, Hudgins L. The spectrum and evolution of phenotypic findings in PTEN mutation positive cases of Bannayan-Riley-Ruvalcaba syndrome. Journal of Medical Genetics. 38: 52-8. PMID 11332402 DOI: 10.1136/JMG.38.1.52  0.315
2001 Astuti D, Douglas F, Lennard TWJ, Aligianis IA, Woodward ER, Evans DGR, Eng C, Latif F, Maher ER. Germline SDHD mutation in familial phaeochromocytoma The Lancet. 357: 1181-1182. PMID 11323050 DOI: 10.1016/S0140-6736(00)04378-6  0.432
2001 Gath R, Goessling A, Keller KM, Koletzko S, Coerdt W, Müntefering H, Wirth S, Hofstra RM, Mulligan L, Eng C, von Deimling A. Analysis of the RET, GDNF, EDN3, and EDNRB genes in patients with intestinal neuronal dysplasia and Hirschsprung disease. Gut. 48: 671-5. PMID 11302967 DOI: 10.1136/Gut.48.5.671  0.41
2001 Gimm O, Chi H, Dahia PLM, Perren A, Hinze R, Komminoth P, Dralle H, Reynolds PR, Eng C. Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas Journal of Clinical Endocrinology and Metabolism. 86: 1801-1805. PMID 11297621 DOI: 10.1210/Jcem.86.4.7419  0.462
2001 Kulke MH, Odze RD, Thakore KS, Thomas G, Wang H, Loda M, Eng C. Allelic loss of 10q23, the PTEN tumour suppressor gene locus, in Barrett's oesophagus-associated adenocarcinoma. British Journal of Cancer. 84: 748-753. PMID 11259087 DOI: 10.1054/Bjoc.2000.1660  0.442
2001 Fackenthal JD, Marsh DJ, Richardson AL, Cummings SA, Eng C, Robinson BG, Olopade OI. Male breast cancer in Cowden syndrome patients with germline PTEN mutations. Journal of Medical Genetics. 38: 159-64. PMID 11238682 DOI: 10.1136/Jmg.38.3.159  0.453
2001 Eng C, Hampel H, Chapelle Adl. Genetic testing for cancer predisposition. Annual Review of Medicine. 52: 371-400. PMID 11160785 DOI: 10.1146/Annurev.Med.52.1.371  0.387
2001 Sweet K, Martin E, Eng C, Shah M. Familial Basal Cell Carcinoma, Melanoma and Skin Hypersensitivity with GIST: A New Hereditary Neuroendocrine Syndrome Involving the SCF/KIT Pathway? International Journal On Disability and Human Development. 2: 161-167. DOI: 10.1515/Ijdhd.2001.2.3.161  0.323
2001 Gimm O, Dziema H, Brown J, De La Puente A, Hoang-Vu C, Dralle H, Plass C, Eng C. Mutation analysis ofNTRK2 andNTRK3, encoding 2 tyrosine kinase receptors, in sporadic human medullary thyroid carcinoma reveals novel sequence variants International Journal of Cancer. 92: 70-74. DOI: 10.1002/1097-0215(200102)9999:9999<::Aid-Ijc1153>3.0.Co;2-N  0.38
2000 Dahia PM, Gimm O, Chi H, Marsh DJ, Reynolds PR, Eng C. Absence of germline mutations in MINPP1, a phosphatase encoding gene centromeric of PTEN, in patients with Cowden and Bannayan-Riley-Ruvalcaba syndrome without germline PTEN mutations [7] Journal of Medical Genetics. 37: 715-717. PMID 11182934 DOI: 10.1136/Jmg.37.9.715  0.473
2000 Bender BU, Gutsche M, Gläsker S, Müller B, Kirste G, Eng C, Neumann HPH. Differential genetic alterations in von Hippel-Lindau syndrome-associated and sporadic pheochromocytomas. The Journal of Clinical Endocrinology and Metabolism. 85: 4568-4574. PMID 11134110 DOI: 10.1210/Jcem.85.12.7015  0.482
2000 Eng C. Will the real Cowden syndrome please stand up: Revised diagnostic criteria Journal of Medical Genetics. 37: 828-830. PMID 11073535 DOI: 10.1136/Jmg.37.11.828  0.4
2000 Zhou X, Gimm O, Hampel H, Niemann T, Walker MJ, Eng C. Epigenetic PTEN Silencing in Malignant Melanomas without PTEN Mutation American Journal of Pathology. 157: 1123-1128. PMID 11021816 DOI: 10.1016/S0002-9440(10)64627-5  0.482
2000 Perren A, Komminoth P, Saremaslani P, Matter C, Feurer S, Lees JA, Heitz PU, Eng C. Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. The American Journal of Pathology. 157: 1097-103. PMID 11021813 DOI: 10.1016/S0002-9440(10)64624-X  0.467
2000 Mueller E, Smith M, Sarraf P, Kroll T, Aiyer A, Kaufman DS, Oh W, Demetri G, Figg WD, Zhou XP, Eng C, Spiegelman BM, Kantoff PW. Effects of ligand activation of peroxisome proliferator-activated receptor γ in human prostate cancer Proceedings of the National Academy of Sciences of the United States of America. 97: 10990-10995. PMID 10984506 DOI: 10.1073/Pnas.180329197  0.319
2000 Syngal S, Fox EA, Eng C, Kolodner RD, Garber JE. Sensitivity and specificity of clinical criteria for hereditary non-polyposis colorectal cancer associated mutations in MSH2 and MLH1. Journal of Medical Genetics. 37: 641-5. PMID 10978352 DOI: 10.1136/Jmg.37.9.641  0.432
2000 Grady WM, Willis J, Guilford PJ, Dunbier AK, Toro TT, Lynch H, Wiesner G, Ferguson K, Eng C, Park JG, Kim SJ, Markowitz S. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer Nature Genetics. 26: 16-17. PMID 10973239 DOI: 10.1038/79120  0.364
2000 Kurose K, Zhou XP, Araki T, Eng C. Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas. Genes, Chromosomes and Cancer. 29: 166-172. PMID 10959096 DOI: 10.1002/1098-2264(2000)9999:9999<::Aid-Gcc1025>3.0.Co;2-M  0.514
2000 Borrego S, Ruiz A, Saez ME, Gimm O, Gao X, López-Alonso M, Hernández A, Wright FA, Antiñolo G, Eng C. RET genotypes comprising specific haplotypes of polymorphic variants predispose to isolated Hirschsprung disease. Journal of Medical Genetics. 37: 572-8. PMID 10922382 DOI: 10.1136/Jmg.37.8.572  0.377
2000 Gimm O, Attié-Bitach T, Lees JA, Vekemans M, Eng C. Expression of the PTEN tumour suppressor protein during human development. Human Molecular Genetics. 9: 1633-9. PMID 10861290 DOI: 10.1093/Hmg/9.11.1633  0.371
2000 Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Eng C. Changes in Endometrial PTEN Expression throughout the Human Menstrual Cycle The Journal of Clinical Endocrinology and Metabolism. 85: 2334-2338. PMID 10852473 DOI: 10.1210/Jcem.85.6.6652  0.328
2000 Zhou XP, Smith WM, Gimm O, Mueller E, Gao X, Sarraf P, Prior TW, Plass C, von Deimling A, Black PM, Yates AJ, Eng C. Over-representation of PPARgamma sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population. Journal of Medical Genetics. 37: 410-4. PMID 10851250 DOI: 10.1136/Jmg.37.6.410  0.419
2000 Eng C. Editorial: Familial papillary thyroid cancer - Many syndromes, too many genes? Journal of Clinical Endocrinology and Metabolism. 85: 1755. PMID 10843147 DOI: 10.1210/Jcem.85.5.6632  0.387
2000 Mutter GL, Lin MC, Fitzgerald JT, Kum JB, Baak JP, Lees JA, Weng LP, Eng C. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. Journal of the National Cancer Institute. 92: 924-30. PMID 10841828 DOI: 10.1093/Jnci/92.11.924  0.486
2000 Yeh JJ, Lunetta KL, van Orsouw NJ, Moore FD, Mutter GL, Vijg J, Dahia PL, Eng C. Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequence variants in cases with thyroid tumours. Oncogene. 19: 2060-6. PMID 10803467 DOI: 10.1038/Sj.Onc.1203537  0.393
2000 Gimm O, Perren A, Weng LP, Marsh DJ, Yeh JJ, Ziebold U, Gil E, Hinze R, Delbridge L, Lees JA, Mutter GL, Robinson BG, Komminoth P, Dralle H, Eng C. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. The American Journal of Pathology. 156: 1693-700. PMID 10793080 DOI: 10.1016/S0002-9440(10)65040-7  0.375
2000 Woodford-Richens K, Bevan S, Churchman M, Dowling B, Jones D, Norbury CG, Hodgson SV, Desai D, Neale K, Phillips RK, Young J, Leggett B, Dunlop M, Rozen P, Eng C, et al. Analysis of genetic and phenotypic heterogeneity in juvenile polyposis. Gut. 46: 656-60. PMID 10764709 DOI: 10.1136/Gut.46.5.656  0.429
2000 Zhou XP, Marsh DJ, Hampel H, Mulliken JB, Gimm O, Eng C. Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. Human Molecular Genetics. 9: 765-8. PMID 10749983 DOI: 10.1093/Hmg/9.5.765  0.465
2000 Hampel H, Allen CM, Chernausek SD, Prior TW, Eng C. De novo RET Mutation Positive Multiple Endocrine Neoplasia Type 2B and Hereditary Nonpolyposis Colorectal Cancer Syndrome Occurring in the Same Family: Parent-of-Origin and Mismatch Repair International Journal On Disability and Human Development. 1: 143-148. DOI: 10.1515/Ijdhd.2000.1.3.143  0.421
2000 Eng C. Editorial: Familial papillary thyroid cancer - Many syndromes, too many genes? The Journal of Clinical Endocrinology and Metabolism. 85. DOI: 10.1210/Jc.85.5.1755  0.387
1999 Faisal Ahmed S, Marsh DJ, Weremowicz S, Morton CC, Williams DM, Eng C. Balanced translocation of 10q and13q, including the PTEN gene, in a boy with a human chorionic gonadotropin-secreting tumor and the Bannayan-Riley-Ruvalcaba syndrome. The Journal of Clinical Endocrinology and Metabolism. 84: 4665-70. PMID 10599735 DOI: 10.1210/Jcem.84.12.6178  0.316
1999 Yeh JJ, Marsh DJ, Zedenius J, Dwight T, Delbridge L, Robinson BG, Eng C. Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways Genes, Chromosomes and Cancer. 26: 322-328. PMID 10534767 DOI: 10.1002/(SICI)1098-2264(199912)26:4<322::AID-GCC6>3.0.CO;2  0.379
1999 Borrego S, Sáez ME, Ruiz A, Gimm O, López-Alonso M, Antiñolo G, Eng C. Specific polymorphisms in the RET proto-oncogene are over-represented in patients with Hirschsprung disease and may represent loci modifying phenotypic expression. Journal of Medical Genetics. 36: 771-4. PMID 10528857 DOI: 10.1136/Jmg.36.10.771  0.383
1999 van Orsouw NJ, Dhanda RK, Elhaji Y, Narod SA, Li FP, Eng C, Vijg J. A highly accurate, low cost test for BRCA1 mutations. Journal of Medical Genetics. 36: 747-53. PMID 10528853 DOI: 10.1136/Jmg.36.10.747  0.454
1999 Perren A, Weng LP, Boag AH, Ziebold U, Thakore K, Dahia PL, Komminoth P, Lees JA, Mulligan LM, Mutter GL, Eng C. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. The American Journal of Pathology. 155: 1253-60. PMID 10514407 DOI: 10.1016/S0002-9440(10)65227-3  0.444
1999 Duerr EM, Gimm O, Neuberg DS, Kum JB, Clifford SC, Toledo SPA, Maher ER, Dahia PLM, Eng C. Differences in allelic distribution of two polymorphisms in the VHL-associated gene CUL2 in pheochromocytoma patients without somatic CUL2 mutations. The Journal of Clinical Endocrinology and Metabolism. 84: 3207-3211. PMID 10487688 DOI: 10.1210/Jcem.84.9.5961  0.468
1999 Eng C. RET proto-oncogene in the development of human cancer Journal of Clinical Oncology. 17: 380-393. PMID 10458257 DOI: 10.1200/Jco.1999.17.1.380  0.497
1999 Bevan S, Woodford-Richens K, Rozen P, Eng C, Young J, Dunlop M, Neale K, Phillips R, Markie D, Rodriguez-Bigas M, Leggett B, Sheridan E, Hodgson S, Iwama T, Eccles D, et al. Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome. Gut. 45: 406-8. PMID 10446110 DOI: 10.1136/Gut.45.3.406  0.466
1999 Gimm O, Greco A, Hoang-Vu C, Dralle H, Pierotti MA, Eng C. Mutation Analysis Reveals Novel Sequence Variants in NTRK1 in Sporadic Human Medullary Thyroid Carcinoma The Journal of Clinical Endocrinology and Metabolism. 84: 2784-2787. PMID 10443680 DOI: 10.1210/Jcem.84.8.5901  0.366
1999 Clifford SC, Walsh S, Hewson K, Green EK, Brinke A, Green PM, Gianelli F, Eng C, Maher ER. Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma development. Genes, Chromosomes & Cancer. 26: 20-8. PMID 10441001 DOI: 10.1002/(Sici)1098-2264(199909)26:1<20::Aid-Gcc3>3.0.Co;2-6  0.463
1999 Syngal S, Fox EA, Li C, Dovidio M, Eng C, Kolodner RD, Garber JE. Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing. Jama. 282: 247-53. PMID 10422993 DOI: 10.1001/Jama.282.3.247  0.31
1999 Gimm O, Gössling A, Marsh DJ, Dahia PLM, Mulligan LM, Deimling AV, Eng C. Mutation and deletion analysis of GFRα-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours British Journal of Cancer. 80: 383-386. PMID 10408842 DOI: 10.1038/Sj.Bjc.6690367  0.352
1999 Marsh DJ, Kum JB, Lunetta KL, Bennett MJ, Gorlin RJ, Ahmed SF, Bodurtha J, Crowe C, Curtis MA, Dasouki M, Dunn T, Feit H, Geraghty MT, Graham JM, Hodgson SV, ... ... Eng C, et al. PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome. Human Molecular Genetics. 8: 1461-72. PMID 10400993 DOI: 10.1093/Hmg/8.8.1461  0.5
1999 Sarraf P, Mueller E, Smith WM, Wright HM, Kum JB, Aaltonen LA, de la Chapelle A, Spiegelman BM, Eng C. Loss-of-function mutations in PPAR gamma associated with human colon cancer. Molecular Cell. 3: 799-804. PMID 10394368 DOI: 10.1016/S1097-2765(01)80012-5  0.376
1999 Laugé A, Lefebvre C, Laurent-Puig P, Caux V, Gad S, Eng C, Longy M, Stoppa-Lyonnet D. No evidence for germline PTEN mutations in families with breast and brain tumours. International Journal of Cancer. 84: 216-219. PMID 10371336 DOI: 10.1002/(Sici)1097-0215(19990621)84:3<216::Aid-Ijc3>3.0.Co;2-E  0.476
1999 Nilsson O, Tisell LE, Jansson S, Ahlman H, Gimm O, Eng C. Adrenal and Extra-adrenal Pheochromocytomas in a Family With Germline RET V804L Mutation Jama. 281: 1587-1588. PMID 10235148 DOI: 10.1001/Jama.281.17.1587  0.422
1999 Otto LR, Boriack RL, Marsh DJ, Kum JB, Eng C, Burlina AB, Bennett MJ. Long‐chain L 3‐hydroxyacyl‐CoA dehydrogenase (LCHAD) deficiency does not appear to be the primary cause of lipid myopathy in patients with Bannayan‐Riley‐Ruvalcaba syndrome (BRRS) American Journal of Medical Genetics. 83: 3-5. PMID 10076877 DOI: 10.1002/(Sici)1096-8628(19990305)83:1<3::Aid-Ajmg2>3.0.Co;2-K  0.412
1999 Feilotter HE, Coulon V, McVeigh JL, Boag AH, Dorion-Bonnet F, Duboué B, Latham WCW, Eng C, Mulligan LM, Longy M. Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma. British Journal of Cancer. 79: 718-723. PMID 10070859 DOI: 10.1038/Sj.Bjc.6690115  0.403
1999 Gimm O, Neuberg DS, Marsh DJ, Dahia PLM, Hoang-Vu C, Raue F, Hinze R, Dralle H, Eng C. Over-representation of a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation Oncogene. 18: 1369-1373. PMID 10022819 DOI: 10.1038/Sj.Onc.1202418  0.385
1999 Dahia PLM, Aguiar RCT, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C, Eng C. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies Human Molecular Genetics. 8: 185-193. PMID 9931326 DOI: 10.1093/Hmg/8.2.185  0.358
1999 Shannon KE, Gimm O, Hinze R, Dralle Η, Eng C. Germline V804M Mutation in the RET Proto-oncogene in Two Apparently Sporadic Cases of MTC Presenting in the Seventh Decade of Life International Journal On Disability and Human Development. 1: 39-46. DOI: 10.1515/Ijdhd.1999.1.1.39  0.406
1999 Vestergaard P, Kroustrup JP, Rønne H, Eng C, Laurberg P. Neuromas in Multiple Endocrine Neoplasia Type 2A with a RET Codon 611 Mutation International Journal On Disability and Human Development. 1: 33-37. DOI: 10.1515/Ijdhd.1999.1.1.33  0.37
1999 Myers SM, Salomon R, Goessling A, Pelet A, Eng C, Deimling AV, Lyonnet S, Mulligan LM. Investigation of germline GFRα-1 mutations in Hirschsprung disease Journal of Medical Genetics. 36: 217-220. DOI: 10.1136/Jmg.36.3.217  0.449
1998 Dhanda RK, Smith WM, Scott CB, Eng C, Vijg J. A simple system for automated two-dimensional electrophoresis: applications to genetic testing. Genetic Testing. 2: 67-70. PMID 10464599 DOI: 10.1089/Gte.1998.2.67  0.394
1998 Smith WM, Van Orsouw NJ, Fox EA, Kolodner RD, Vijg J, Eng C. Accurate, high-throughput "snapshot" detection of hMLH1 mutations by two-dimensional DNA electrophoresis. Genetic Testing. 2: 43-53. PMID 10464596 DOI: 10.1089/Gte.1998.2.43  0.451
1998 Dabora SL, Sigalas I, Hall F, Eng C, Vijg J, Kwiatkowski DJ. Comprehensive mutation analysis of TSC1 using two-dimensional DNA electrophoresis with DGGE. Annals of Human Genetics. 62: 491-504. PMID 10363127 DOI: 10.1046/J.1469-1809.1998.6260491.X  0.446
1998 Zori RT, Marsh DJ, Graham GE, Marliss EB, Eng C. Germline PTEN mutation in a family with Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. American Journal of Medical Genetics. 80: 399-402. PMID 9856571 DOI: 10.1002/(Sici)1096-8628(19981204)80:4<399::Aid-Ajmg18>3.0.Co;2-O  0.459
1998 Eng C, Thomas GA, Neuberg DS, Mulligan LM, Healey CS, Houghton C, Frilling A, Raue F, Williams ED, Ponder BA. Mutation of the RET proto-oncogene is correlated with RET immunostaining in subpopulations of cells in sporadic medullary thyroid carcinoma. The Journal of Clinical Endocrinology and Metabolism. 83: 4310-3. PMID 9851769 DOI: 10.1210/Jcem.83.12.5345  0.478
1998 Eng C, Marsh DJ, Robinson BG, Chow CW, Patton MA, Southey MC, Venter DJ, Ponder BA, Milla PJ, Smith VV. Germline RET codon 918 mutation in apparently isolated intestinal ganglioneuromatosis. The Journal of Clinical Endocrinology and Metabolism. 83: 4191-4. PMID 9851750 DOI: 10.1210/Jcem.83.12.5352  0.392
1998 Longy M, Coulon V, Duboué B, David A, Larrègue M, Eng C, Amati P, Kraimps JL, Bottani A, Lacombe D, Bonneau D. Mutations of PTEN in patients with Bannayan-Riley-Ruvalcaba phenotype. Journal of Medical Genetics. 35: 886-889. PMID 9832032 DOI: 10.1136/Jmg.35.11.886  0.47
1998 Marsh DJ, Dahia PLM, Caron S, Kum JB, Frayling IM, Tomlinson IPM, Hughes KS, Eeles RA, Hodgson SV, Murday VA, Houlston R, Eng C. Germline PTEN mutations in Cowden syndrome-like families. Journal of Medical Genetics. 35: 881-885. PMID 9832031 DOI: 10.1136/Jmg.35.11.881  0.468
1998 Houlston R, Bevan S, Williams A, Young J, Dunlop M, Rozen P, Eng C, Markie D, Woodford-Richens K, Rodriguez-Bigas MA, Leggett B, Neale K, Phillips R, Sheridan E, Hodgson S, et al. Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases. Human Molecular Genetics. 7: 1907-12. PMID 9811934 DOI: 10.1093/Hmg/7.12.1907  0.499
1998 Somerville RP, Shoshan Y, Eng C, Barnett G, Miller D, Cowell JK. Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in glioblastoma multiforme disease progression. Oncogene. 17: 1755-7. PMID 9796706 DOI: 10.1038/Sj.Onc.1202066  0.414
1998 Dhanda RK, van Orsouw NJ, Sigalas I, Eng C, Vijg J. Critical factors in the performance and cost of two-dimensional gene scanning: RB1 as a model. Biotechniques. 25: 664-8, 670, 672-5. PMID 9793651 DOI: 10.2144/98254Dt06  0.33
1998 Borrego S, Eng C, Sánchez B, Sáez ME, Navarro E, Antiñolo G. Molecular analysis of the ret and GDNF genes in a family with multiple endocrine neoplasia type 2A and Hirschsprung disease. The Journal of Clinical Endocrinology and Metabolism. 83: 3361-4. PMID 9745455 DOI: 10.1210/Jcem.83.9.5093  0.475
1998 Lehrer S, Fodor F, Stock RG, Stone NN, Eng C, Song HK, McGovern M. Absence of 185delAG mutation of the BRCA1 gene and 6174delT mutation of the BRCA2 gene in Ashkenazi Jewish men with prostate cancer. British Journal of Cancer. 78: 771-773. PMID 9743298 DOI: 10.1038/Bjc.1998.576  0.421
1998 FitzGerald MG, Marsh DJ, Wahrer D, Bell D, Caron S, Shannon KE, Ishioka C, Isselbacher KJ, Garber JE, Eng C, Haber DA. Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer. Oncogene. 17: 727-31. PMID 9715274 DOI: 10.1038/Sj.Onc.1201984  0.468
1998 Stratakis CA, Kirschner LS, Taymans SE, Tomlinson IP, Marsh DJ, Torpy DJ, Giatzakis C, Eccles DM, Theaker J, Houlston RS, Blouin JL, Antonarakis SE, Basson CT, Eng C, Carney JA. Carney complex, Peutz-Jeghers syndrome, Cowden disease, and Bannayan-Zonana syndrome share cutaneous and endocrine manifestations, but not genetic loci. The Journal of Clinical Endocrinology and Metabolism. 83: 2972-6. PMID 9709978 DOI: 10.1210/Jcem.83.8.5042  0.393
1998 Pesche S, Latil A, Muzeau F, Cussenot O, Fournier G, Longy M, Eng C, Lidereau R. PTEN/MMAC1/TEP1 involvement in primary prostate cancers Oncogene. 16: 2879-2883. PMID 9671408 DOI: 10.1038/Sj.Onc.1202081  0.455
1998 Rines RD, Orsouw NJv, Sigalas I, Li FP, Eng C, Vijg J. Comprehensive mutational scanning of the p53 coding region by two-dimensional gene scanning. Carcinogenesis. 19: 979-984. PMID 9667734 DOI: 10.1093/Carcin/19.6.979  0.38
1998 Eng C, Peacocke M. PTEN and inherited hamartoma-cancer syndromes [4] Nature Genetics. 19: 223. PMID 9662392 DOI: 10.1038/897  0.366
1998 Dahia PL, FitzGerald MG, Zhang X, Marsh DJ, Zheng Z, Pietsch T, von Deimling A, Haluska FG, Haber DA, Eng C. A highly conserved processed PTEN pseudogene is located on chromosome band 9p21. Oncogene. 16: 2403-6. PMID 9620558 DOI: 10.1038/Sj.Onc.1201762  0.465
1998 Duerr EM, Rollbrocker B, Hayashi Y, Peters N, Meyer-Puttlitz B, Louis DN, Schramm J, Wiestler OD, Parsons R, Eng C, von Deimling A. PTEN mutations in gliomas and glioneuronal tumors. Oncogene. 16: 2259-64. PMID 9619835 DOI: 10.1038/Sj.Onc.1201756  0.44
1998 Feilotter HE, Nagai MA, Boag AH, Eng C, Mulligan LM. Analysis of PTEN and the 10q23 region in primary prostate carcinomas. Oncogene. 16: 1743-1748. PMID 9582022 DOI: 10.1038/Sj.Onc.1200205  0.371
1998 van Orsouw NJ, Dhanda RK, Rines RD, Smith WM, Sigalas I, Eng C, Vijg J. Rapid design of denaturing gradient-based two-dimensional electrophoretic gene mutational scanning tests. Nucleic Acids Research. 26: 2398-406. PMID 9580692 DOI: 10.1093/Nar/26.10.2398  0.353
1998 Mulligan LM, Timmer T, Ivanchuk SM, Campling BG, Young LC, Rabbitts PH, Sundaresan V, Hofstra RM, Eng C. Investigation of the genes for RET and its ligand complex, GDNF/GFR alpha-I, in small cell lung carcinoma. Genes, Chromosomes & Cancer. 21: 326-32. PMID 9559344 DOI: 10.1002/(Sici)1098-2264(199804)21:4<326::Aid-Gcc6>3.0.Co;2-0  0.426
1998 Peters N, Wellenreuther R, Rollbrocker B, Hayashi Y, Meyer-Puttlitz B, Duerr EM, Lenartz D, Marsh DJ, Schramm J, Wiestler OD, Parsons R, Eng C, Deimling AV. Analysis of the PTEN gene in human meningiomas Neuropathology and Applied Neurobiology. 24: 3-8. PMID 9549723 DOI: 10.1046/J.1365-2990.1998.00093.X  0.442
1998 Eng C, Ji H. Molecular classification of the inherited hamartoma polyposis syndromes: Clearing the muddied waters American Journal of Human Genetics. 62: 1020-1022. PMID 9545417 DOI: 10.1086/301847  0.333
1998 Eng C. Genetics of Cowden syndrome: Through the looking glass of oncology (Review) International Journal of Oncology. 12: 701-710. PMID 9472113 DOI: 10.3892/Ijo.12.3.701  0.476
1998 Schuffenecker I, Virally-Monod M, Brohet R, Goldgar D, Conte-Devolx B, Leclerc L, Chabre O, Boneu A, Caron J, Houdent C, Modigliani E, Rohmer V, Schlumberger M, Eng C, Guillausseau PJ, et al. Risk and penetrance of primary hyperparathyroidism in multiple endocrine neoplasia type 2A families with mutations at codon 634 of the RET proto-oncogene. Groupe D'etude des Tumeurs à Calcitonine. The Journal of Clinical Endocrinology and Metabolism. 83: 487-91. PMID 9467562 DOI: 10.1210/JCEM.83.2.4529  0.359
1998 Marsh DJ, Coulon V, Lunetta KL, Rocca-Serra P, Dahia PL, Zheng Z, Liaw D, Caron S, Duboué B, Lin AY, Richardson AL, Bonnetblanc JM, Bressieux JM, Cabarrot-Moreau A, Chompret A, ... ... Eng C, et al. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Human Molecular Genetics. 7: 507-15. PMID 9467011 DOI: 10.1093/Hmg/7.3.507  0.48
1998 Marsh DJ, Andrew SD, Learoyd DL, Pojer R, Eng C, Robinson BG. Deletion‐insertion mutation encompassing RET codon 634 is associated with medullary thyroid carcinoma Human Mutation. 11. PMID 9452023 DOI: 10.1002/Humu.1380110102  0.405
1998 Marsh DJ, Dahia PL, Coulon V, Zheng Z, Dorion-Bonnet F, Call KM, Little R, Lin AY, Eeles RA, Goldstein AM, Hodgson SV, Richardson AL, Robinson BG, Weber HC, Longy M, ... Eng C, et al. Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes, Chromosomes & Cancer. 21: 61-9. PMID 9443042 DOI: 10.1002/(Sici)1098-2264(199801)21:1<61::Aid-Gcc8>3.0.Co;2-6  0.38
1998 Schuffenecker I, Virally-Monod M, Brohet R, Goldgar D, Conte-Devolx B, Leclerc L, Chabre O, Boneu A, Caron J, Houdent C, Modigliani E, Rohmer V, Schlumberger M, Eng C, Guillausseau PJ, et al. Risk and Penetrance of Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 2A Families with Mutations at Codon 634 of the RET Proto-Oncogene The Journal of Clinical Endocrinology and Metabolism. 83: 487-491. DOI: 10.1210/Jc.83.2.487  0.452
1998 Eng C. A novel tumor suppressor gene on chromosome 10 and its role in endocrine neoplasia Current Opinion in Endocrinology & Diabetes. 5: 40-48. DOI: 10.1097/00060793-199802000-00008  0.318
1998 Weber H, Marsh D, Lubensky I, Lin A, Eng C. Germline PTEN/MMAC1/TEP1 mutations and association with gastrointestinal manifestations in Cowden disease Gastroenterology. 114: A702. DOI: 10.1016/S0016-5085(98)82880-1  0.428
1997 Gimm O, Marsh DJ, Andrew SD, Frilling A, Dahia PLM, Mulligan LM, Zajac JD, Robinson BG, Eng C. Germline dinucleotide mutation in codon 883 of the RET proto-oncogene in multiple endocrine neoplasia type 2B without codon 918 mutation The Journal of Clinical Endocrinology and Metabolism. 82: 3902-3904. PMID 9360560 DOI: 10.1210/Jcem.82.11.4508  0.412
1997 Tsou HC, Teng DH, Ping XL, Brancolini V, Davis T, Hu R, Xie XX, Gruener AC, Schrager CA, Christiano AM, Eng C, Steck P, Ott J, Tavtigian SV, Peacocke M. The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases. American Journal of Human Genetics. 61: 1036-43. PMID 9345101 DOI: 10.1086/301607  0.483
1997 Marsh DJ, Zheng Z, Arnold A, Andrew SD, Learoyd D, Frilling A, Komminoth P, Neumann HP, Ponder BA, Rollins BJ, Shapiro GI, Robinson BG, Mulligan LM, Eng C. Mutation analysis of glial cell line-derived neurotrophic factor, a ligand for an RET/coreceptor complex, in multiple endocrine neoplasia type 2 and sporadic neuroendocrine tumors. The Journal of Clinical Endocrinology and Metabolism. 82: 3025-8. PMID 9284737 DOI: 10.1210/Jcem.82.9.4197  0.477
1997 Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 94: 9052-7. PMID 9256433 DOI: 10.1073/Pnas.94.17.9052  0.336
1997 Eng C. From bench to bedside ... But when? Genome Research. 7: 669-672. PMID 9253596 DOI: 10.1101/Gr.7.7.669  0.406
1997 Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ, Eng C. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nature Genetics. 16: 333-4. PMID 9241266 DOI: 10.1038/Ng0897-333  0.448
1997 Woodward ER, Eng C, McMahon R, Voutilainen R, Affara NA, Ponder BAJ, Maher ER. Genetic Predisposition to Phaeochromocytoma: Analysis of Candidate Genes GDNF, RET and VHL Human Molecular Genetics. 6: 1051-1056. PMID 9215674 DOI: 10.1093/Hmg/6.7.1051  0.485
1997 Edery P, Munnich A, Lyonnet S, Eng C. Ret in human development and oncogenesis Bioessays. 19: 389-395. PMID 9174404 DOI: 10.1002/Bies.950190506  0.429
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