| Year |
Citation |
Score |
| 2024 |
Li Y, Liu X, Fujinaga K, Gross JD, Frankel AD. Enhanced NF-κB activation via HIV-1 Tat-TRAF6 cross-talk. Science Advances. 10: eadi4162. PMID 38241362 DOI: 10.1126/sciadv.adi4162 |
0.466 |
|
| 2022 |
Fujinaga K, Huang F, Peterlin BM. P-TEFb: The master regulator of transcription elongation. Molecular Cell. PMID 36599353 DOI: 10.1016/j.molcel.2022.12.006 |
0.447 |
|
| 2022 |
Huang F, Yao W, Sun B, Fujinaga K. DCAF1 inhibits the NF-κB pathway by targeting p65. Immunology Letters. PMID 36055411 DOI: 10.1016/j.imlet.2022.08.005 |
0.345 |
|
| 2022 |
Huang F, Feng Y, Peterlin BM, Fujinaga K. P-TEFb is degraded by Siah1/2 in quiescent cells. Nucleic Acids Research. PMID 35524561 DOI: 10.1093/nar/gkac291 |
0.355 |
|
| 2021 |
Huang F, Nguyen TT, Echeverria I, Ramachandran R, Cary DC, Paculova H, Sali A, Weiss A, Peterlin BM, Fujinaga K. Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb. Elife. 10. PMID 34821217 DOI: 10.7554/eLife.68473 |
0.463 |
|
| 2020 |
Fujinaga K, Cary DC. Experimental Systems for Measuring HIV Latency and Reactivation. Viruses. 12. PMID 33182414 DOI: 10.3390/v12111279 |
0.393 |
|
| 2020 |
Kong W, Biswas A, Zhou D, Fiches G, Fujinaga K, Santoso N, Zhu J. Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation. Plos Pathogens. 16: e1008430. PMID 32176734 DOI: 10.1371/Journal.Ppat.1008430 |
0.562 |
|
| 2020 |
Fujinaga K. P-TEFb as A Promising Therapeutic Target Molecules. 25: 838. PMID 32075058 DOI: 10.3390/Molecules25040838 |
0.554 |
|
| 2019 |
Krasnopolsky S, Marom L, Victor RA, Kuzmina A, Schwartz JC, Fujinaga K, Taube R. Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation. Retrovirology. 16: 16. PMID 31238957 DOI: 10.1186/S12977-019-0478-X |
0.576 |
|
| 2019 |
Bugai A, Quaresma AJC, Friedel CC, Lenasi T, Düster R, Sibley CR, Fujinaga K, Kukanja P, Hennig T, Blasius M, Geyer M, Ule J, Dölken L, Barborič M. P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress Molecular Cell. 74: 254. PMID 30824372 DOI: 10.1016/J.Molcel.2019.01.033 |
0.466 |
|
| 2018 |
Leoz M, Kukanja P, Luo Z, Huang F, Cary DC, Peterlin BM, Fujinaga K. HEXIM1-Tat chimera inhibits HIV-1 replication. Plos Pathogens. 14: e1007402. PMID 30395647 DOI: 10.1371/Journal.Ppat.1007402 |
0.591 |
|
| 2018 |
Asamitsu K, Fujinaga K, Okamoto T. HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV Therapies. Molecules (Basel, Switzerland). 23. PMID 29673219 DOI: 10.3390/Molecules23040933 |
0.609 |
|
| 2018 |
Huang F, Shao W, Fujinaga K, Peterlin BM. Bromodomian-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB. The Journal of Biological Chemistry. PMID 29463681 DOI: 10.1074/Jbc.Ra117.001518 |
0.432 |
|
| 2017 |
Contreras-Galindo RA, Dube D, Fujinaga K, Kaplan MH, Markovitz DM. Susceptibility of Human Endogenous Retrovirus Type-K to Reverse Transcriptase Inhibitors. Journal of Virology. PMID 28931682 DOI: 10.1128/Jvi.01309-17 |
0.414 |
|
| 2017 |
Peterlin BM, Liu P, Wang X, Cary D, Shao W, Leoz M, Hong T, Pan T, Fujinaga K. Hili inhibits HIV replication in activated T cells. Journal of Virology. PMID 28331090 DOI: 10.1128/Jvi.00237-17 |
0.523 |
|
| 2016 |
Cary DC, Fujinaga K, Peterlin BM. Euphorbia Kansui Reactivates Latent HIV. Plos One. 11. PMID 27977742 DOI: 10.1371/Journal.Pone.0168027 |
0.51 |
|
| 2016 |
Shao W, Zumer K, Fujinaga K, Peterlin BM. FBXO3 Promotes Ubiquitylation and Transcriptional Activity of AIRE. The Journal of Biological Chemistry. PMID 27365398 DOI: 10.1074/Jbc.M116.724401 |
0.45 |
|
| 2016 |
Tan JL, Fogley RD, Flynn RA, Ablain J, Yang S, Saint-André V, Fan ZP, Do BT, Laga AC, Fujinaga K, Santoriello C, Greer CB, Kim YJ, Clohessy JG, Bothmer A, et al. Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molecular Cell. 62: 34-46. PMID 27058786 DOI: 10.1016/J.Molcel.2016.03.013 |
0.414 |
|
| 2016 |
Barboric M, Fujinaga K. The two sides of Tat. Elife. 5: e12686. PMID 26783762 DOI: 10.7554/Elife.12686 |
0.462 |
|
| 2016 |
Cary DC, Fujinaga K, Peterlin BM. Molecular mechanisms of HIV latency. The Journal of Clinical Investigation. 126: 448-54. PMID 26731470 DOI: 10.1172/Jci80565 |
0.591 |
|
| 2015 |
Pak V, Eifler TT, Jäger S, Krogan NJ, Fujinaga K, Peterlin BM. CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing. Cell Host & Microbe. 18: 560-70. PMID 26567509 DOI: 10.1016/J.Chom.2015.10.012 |
0.564 |
|
| 2015 |
Darcis G, Kula A, Bouchat S, Fujinaga K, Corazza F, Ait-Ammar A, Delacourt N, Melard A, Kabeya K, Vanhulle C, Van Driessche B, Gatot JS, Cherrier T, Pianowski LF, Gama L, et al. An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression. Plos Pathogens. 11: e1005063. PMID 26225566 DOI: 10.1371/Journal.Ppat.1005063 |
0.551 |
|
| 2015 |
Fujinaga K, Luo Z, Schaufele F, Peterlin BM. Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells. The Journal of Biological Chemistry. 290: 1829-36. PMID 25492871 DOI: 10.1074/Jbc.M114.605816 |
0.479 |
|
| 2015 |
Eifler TT, Shao W, Bartholomeeusen K, Fujinaga K, Jäger S, Johnson JR, Luo Z, Krogan NJ, Peterlin BM. Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts. Molecular and Cellular Biology. 35: 468-78. PMID 25384976 DOI: 10.1128/Mcb.01157-14 |
0.43 |
|
| 2014 |
Fujinaga K, Luo Z, Peterlin BM. Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells. The Journal of Biological Chemistry. 289: 21181-90. PMID 24917669 DOI: 10.1074/Jbc.M114.557751 |
0.495 |
|
| 2014 |
Jadlowsky JK, Wong JY, Graham AC, Dobrowolski C, Devor RL, Adams MD, Fujinaga K, Karn J. Negative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat. Molecular and Cellular Biology. 34: 1911-28. PMID 24636995 DOI: 10.1128/Mcb.01013-13 |
0.546 |
|
| 2014 |
Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM. Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription. The Journal of Biological Chemistry. 289: 9918-25. PMID 24515107 DOI: 10.1074/Jbc.M113.539015 |
0.498 |
|
| 2013 |
Bartholomeeusen K, Fujinaga K, Xiang Y, Peterlin BM. Histone deacetylase inhibitors (HDACis) that release the positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription. The Journal of Biological Chemistry. 288: 14400-7. PMID 23539624 DOI: 10.1074/Jbc.M113.464834 |
0.567 |
|
| 2012 |
Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM. Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. The Journal of Biological Chemistry. 287: 36609-16. PMID 22952229 DOI: 10.1074/Jbc.M112.410746 |
0.58 |
|
| 2012 |
Fujinaga K, Barboric M, Li Q, Luo Z, Price DH, Peterlin BM. PKC phosphorylates HEXIM1 and regulates P-TEFb activity. Nucleic Acids Research. 40: 9160-70. PMID 22821562 DOI: 10.1093/Nar/Gks682 |
0.477 |
|
| 2012 |
Kuzmina A, Hadad U, Fujinaga K, Taube R. Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1. Virology. 426: 152-61. PMID 22342181 DOI: 10.1016/J.Virol.2012.01.033 |
0.571 |
|
| 2012 |
Toossi Z, Wu M, Hirsch CS, Mayanja-Kizza H, Baseke J, Aung H, Canaday DH, Fujinaga K. Activation of P-TEFb at sites of dual HIV/TB infection, and inhibition of MTB-induced HIV transcriptional activation by the inhibitor of CDK9, Indirubin-3'-monoxime. Aids Research and Human Retroviruses. 28: 182-7. PMID 21453127 DOI: 10.1089/Aid.2010.0211 |
0.496 |
|
| 2010 |
van Grol J, Subauste C, Andrade RM, Fujinaga K, Nelson J, Subauste CS. HIV-1 inhibits autophagy in bystander macrophage/ monocytic cells through Src-Akt and STAT3 Plos One. 5. PMID 20661303 DOI: 10.1371/Journal.Pone.0011733 |
0.474 |
|
| 2009 |
Imai K, Asamitsu K, Victoriano AF, Cueno ME, Fujinaga K, Okamoto T. Cyclin T1 stabilizes expression levels of HIV-1 Tat in cells. The Febs Journal. 276: 7124-33. PMID 20064163 DOI: 10.1111/J.1742-4658.2009.07424.X |
0.595 |
|
| 2008 |
Jadlowsky JK, Nojima M, Okamoto T, Fujinaga K. Dominant negative mutant cyclin T1 proteins that inhibit HIV transcription by forming a kinase inactive complex with Tat. The Journal of General Virology. 89: 2783-7. PMID 18931076 DOI: 10.1099/Vir.0.2008/002857-0 |
0.616 |
|
| 2008 |
Ogba N, Chaplin LJ, Doughman YQ, Fujinaga K, Montano MM. HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. Cancer Research. 68: 7015-24. PMID 18757415 DOI: 10.1158/0008-5472.Can-08-0814 |
0.422 |
|
| 2008 |
Nojima M, Huang Y, Tyagi M, Kao HY, Fujinaga K. The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2. Journal of Molecular Biology. 382: 275-87. PMID 18662700 DOI: 10.1016/J.Jmb.2008.07.017 |
0.514 |
|
| 2008 |
Jadlowsky JK, Nojima M, Schulte A, Geyer M, Okamoto T, Fujinaga K. Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat. Retrovirology. 5: 63. PMID 18620576 DOI: 10.1186/1742-4690-5-63 |
0.601 |
|
| 2007 |
Anand K, Schulte A, Fujinaga K, Scheffzek K, Geyer M. Cyclin box structure of the P-TEFb subunit cyclin T1 derived from a fusion complex with EIAV tat. Journal of Molecular Biology. 370: 826-36. PMID 17540406 DOI: 10.1016/J.Jmb.2007.04.077 |
0.571 |
|
| 2005 |
Wittmann BM, Fujinaga K, Deng H, Ogba N, Montano MM. The breast cell growth inhibitor, estrogen down regulated gene 1, modulates a novel functional interaction between estrogen receptor alpha and transcriptional elongation factor cyclin T1. Oncogene. 24: 5576-88. PMID 15940264 DOI: 10.1038/Sj.Onc.1208728 |
0.438 |
|
| 2004 |
Fujinaga K, Irwin D, Huang Y, Taube R, Kurosu T, Peterlin BM. Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element. Molecular and Cellular Biology. 24: 787-95. PMID 14701750 DOI: 10.1128/Mcb.24.2.787-795.2004 |
0.587 |
|
| 2002 |
Fujinaga K, Irwin D, Taube R, Zhang F, Geyer M, Peterlin BM. A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells. Journal of Virology. 76: 12934-9. PMID 12438619 DOI: 10.1128/Jvi.76.24.12934-12939.2002 |
0.606 |
|
| 2002 |
Fujinaga K, Irwin D, Geyer M, Peterlin BM. Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression. Journal of Virology. 76: 10873-81. PMID 12368330 DOI: 10.1128/Jvi.76.21.10873-10881.2002 |
0.578 |
|
| 2002 |
Tobiume M, Fujinaga K, Suzuki S, Komoto S, Mukai T, Ikuta K. Extracellular Nef protein activates signal transduction pathway from Ras to mitogen-activated protein kinase cascades that leads to activation of human immunodeficiency virus from latency. Aids Research and Human Retroviruses. 18: 461-7. PMID 11958689 DOI: 10.1089/088922202753614227 |
0.379 |
|
| 2002 |
Lin X, Taube R, Fujinaga K, Peterlin BM. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. The Journal of Biological Chemistry. 277: 16873-8. PMID 11884399 DOI: 10.1074/Jbc.M200117200 |
0.487 |
|
| 2002 |
Lind KE, Du Z, Fujinaga K, Peterlin BM, James TL. Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA. Chemistry & Biology. 9: 185-93. PMID 11880033 DOI: 10.1016/S1074-5521(02)00106-0 |
0.386 |
|
| 2002 |
Taube R, Lin X, Irwin D, Fujinaga K, Peterlin BM. Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Molecular and Cellular Biology. 22: 321-31. PMID 11739744 DOI: 10.1128/Mcb.22.1.321-331.2002 |
0.489 |
|
| 2000 |
Chao S, Fujinaga K, Marion JE, Taube R, Sausville EA, Senderowicz AM, Peterlin BM, Price DH. Flavopiridol inhibits P-TEFb and blocks HIV-1 replication. Journal of Biological Chemistry. 275: 28345-28348. PMID 10906320 DOI: 10.1074/Jbc.C000446200 |
0.562 |
|
| 2000 |
Barboric M, Taube R, Nekrep N, Fujinaga K, Peterlin BM. Binding of Tat to TAR and Recruitment of Positive Transcription Elongation Factor b Occur Independently in Bovine Immunodeficiency Virus Journal of Virology. 74: 6039-6044. PMID 10846086 DOI: 10.1128/Jvi.74.13.6039-6044.2000 |
0.513 |
|
| 2000 |
Taube R, Fujinaga K, Irwin D, Wimmer J, Geyer M, Peterlin BM. Interactions between Equine Cyclin T1, Tat, and TAR Are Disrupted by a Leucine-to-Valine Substitution Found in Human Cyclin T1 Journal of Virology. 74: 892-898. PMID 10623752 DOI: 10.1128/Jvi.74.2.892-898.2000 |
0.476 |
|
| 1999 |
Taube R, Fujinaga K, Wimmer J, Barboric M, Peterlin BM. Tat transactivation: a model for the regulation of eukaryotic transcriptional elongation. Virology. 264: 245-253. PMID 10562489 DOI: 10.1006/Viro.1999.9944 |
0.482 |
|
| 1999 |
Wimmer J, Fujinaga K, Taube R, Cujec TP, Zhu Y, Peng J, Price DH, Peterlin BM. Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. Virology. 255: 182-189. PMID 10049833 DOI: 10.1006/Viro.1998.9589 |
0.491 |
|
| 1998 |
Fujinaga K, Cujec TP, Peng J, Garriga J, Price DH, Graña X, Peterlin BM. The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat. Journal of Virology. 72: 7154-7159. PMID 9696809 DOI: 10.1128/Jvi.72.9.7154-7159.1998 |
0.602 |
|
| 1998 |
Tobiume M, Fujinaga K, Kameoka M, Kimura T, Nakaya T, Yamada T, Ikuta K. Dependence on host cell cycle for activation of human immunodeficiency virus type 1 gene expression from latency. The Journal of General Virology. 1363-71. PMID 9634076 DOI: 10.1099/0022-1317-79-6-1363 |
0.501 |
|
| 1998 |
Kameoka M, Suzuki S, Kimura T, Fujinaga K, Auwanit W, Luftig RB, Ikuta K. Exposure of resting peripheral blood T cells to HIV-1 particles generates CD25+ killer cells in a small subset, leading to induction of apoptosis in bystander cells. International Immunology. 9: 1453-62. PMID 9352350 DOI: 10.1093/Intimm/9.10.1453 |
0.351 |
|
| 1997 |
Zhong Q, Nakaya T, Tateno Y, Fujinaga K, Kameoka M, Tateno M, Ikuta K. A clearer distinction between HIV-1 paired isolates from peripheral blood mononuclear cells of asymptomatic carriers with and without CD8+ T-cells at nef rather than env V3 loci. Vaccine. 15: 497-510. PMID 9160517 DOI: 10.1016/S0264-410X(97)00223-5 |
0.401 |
|
| 1997 |
Bahmani MK, Kameoka M, Nakaya T, Fujinaga K, Zhong Q, Takahashi H, Nakano T, Nakai M, Ueda S, Jones IM, Luftig RB, Ikuta K. Production of doughnut-shaped, protease-defective particles from a human T cell clone carrying a provirus with specific mutations in the env, pol, vpr, and nef genes Aids Research and Human Retroviruses. 13: 523-526. PMID 9100995 DOI: 10.1089/Aid.1997.13.523 |
0.33 |
|
| 1997 |
Kameoka M, Kimura T, Zheng YH, Suzuki S, Fujinaga K, Luftig RB, Ikuta K. Protease-defective, gp120-containing human immunodeficiency virus type 1 particles induce apoptosis more efficiently than does wild-type virus or recombinant gp120 protein in healthy donor-derived peripheral blood T cells. Journal of Clinical Microbiology. 35: 41-7. PMID 8968878 DOI: 10.1128/Jcm.35.1.41-47.1997 |
0.402 |
|
| 1994 |
Nishino Y, Nakaya T, Fujinaga K, Kishi M, Azuma I, Ikuta K. Persistent infection of MT-4 cells by human immunodeficiency virus type 1 becomes increasingly likely with in vitro serial passage of wild-type but not nef mutant virus. Journal of General Virology. 75: 2241-2251. PMID 7521392 DOI: 10.1099/0022-1317-75-9-2241 |
0.473 |
|
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