Ruben Abagyan - Publications

Affiliations: 
Skaggs School of Pharmacy and Pharmaceutical Sciences University of California, San Diego, La Jolla, CA 

33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Wammer KH, Anderson KC, Erickson PR, Kliegman S, Moffatt ME, Berg SM, Heitzman JA, Pflug N, McNeill K, Martinovic-Weigelt D, Abagyan R, Cwiertny DM, Kolodziej EP. Environmental Photochemistry of Altrenogest: Photoisomerization to a Bioactive Product with Increased Environmental Persistence via Reversible Photohydration. Environmental Science & Technology. PMID 27356268 DOI: 10.1021/acs.est.6b02608  0.56
2015 Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, ... ... Abagyan R, et al. Corrigendum: Lanosterol reverses protein aggregation in cataracts. Nature. PMID 26308894 DOI: 10.1038/nature15253  0.48
2015 Zhao L, Chen XJ, Zhu J, Xi YB, Yang X, Hu LD, Ouyang H, Patel SH, Jin X, Lin D, Wu F, Flagg K, Cai H, Li G, Cao G, ... ... Abagyan R, et al. Lanosterol reverses protein aggregation in cataracts. Nature. PMID 26200341 DOI: 10.1038/nature14650  0.48
2014 Wang Y, Chan FY, Sun N, Lui HK, So PK, Yan SC, Chan KF, Chiou J, Chen S, Abagyan R, Leung YC, Wong KY. Structure-based design, synthesis, and biological evaluation of isatin derivatives as potential glycosyltransferase inhibitors. Chemical Biology & Drug Design. 84: 685-96. PMID 24890564 DOI: 10.1111/cbdd.12361  0.48
2014 Sun N, Chan FY, Lu YJ, Neves MA, Lui HK, Wang Y, Chow KY, Chan KF, Yan SC, Leung YC, Abagyan R, Chan TH, Wong KY. Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity. Plos One. 9: e97514. PMID 24824618 DOI: 10.1371/journal.pone.0097514  0.56
2014 Gabrielsen M, Kurczab R, Siwek A, Wolak M, Ravna AW, Kristiansen K, Kufareva I, Abagyan R, Nowak G, Chilmonczyk Z, Sylte I, Bojarski AJ. Identification of novel serotonin transporter compounds by virtual screening. Journal of Chemical Information and Modeling. 54: 933-43. PMID 24521202 DOI: 10.1021/ci400742s  0.56
2014 Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. A general method for site specific fluorescent labeling of recombinant chemokines. Plos One. 9: e81454. PMID 24489642 DOI: 10.1371/journal.pone.0081454  0.56
2014 Matos KS, da Cunha EF, Abagyan R, Ramalho TC. Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. Combinatorial Chemistry & High Throughput Screening. 17: 554-64. PMID 24344993  0.56
2013 Chan FY, Sun N, Neves MA, Lam PC, Chung WH, Wong LK, Chow HY, Ma DL, Chan PH, Leung YC, Chan TH, Abagyan R, Wong KY. Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening. Journal of Chemical Information and Modeling. 53: 2131-40. PMID 23848971 DOI: 10.1021/ci400203f  0.56
2013 Harikumar KG, Cawston EE, Lam PC, Patil A, Orry A, Henke BR, Abagyan R, Christopoulos A, Sexton PM, Miller LJ. Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor. The Journal of Biological Chemistry. 288: 21082-95. PMID 23754289 DOI: 10.1074/jbc.M113.480715  0.56
2013 Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel TM. A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer. Methods in Molecular Biology (Clifton, N.J.). 1013: 93-127. PMID 23625495 DOI: 10.1007/978-1-62703-426-5_7  0.56
2013 Gabrielsen M, WoÅ‚osewicz K, Zawadzka A, Kossakowski J, Nowak G, Wolak M, Stachowicz K, Siwek A, Ravna AW, Kufareva I, Kozerski L, Bednarek E, Sitkowski J, Bocian W, Abagyan R, et al. Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors. Chemical Biology & Drug Design. 81: 695-706. PMID 23574807 DOI: 10.1111/cbdd.12116  0.56
2013 Katiyar S, Kufareva I, Behera R, Thomas SM, Ogata Y, Pollastri M, Abagyan R, Mensa-Wilmot K. Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds. Plos One. 8: e56150. PMID 23437089 DOI: 10.1371/journal.pone.0056150  0.56
2012 Dong M, Xu X, Ball AM, Makhoul JA, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ. Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 5092-105. PMID 22964305 DOI: 10.1096/fj.12-212399  0.56
2012 Wein AN, Williams BN, Liu S, Ermolinsky B, Provenzano D, Abagyan R, Orry A, Leppla SH, Peredelchuk M. Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization Journal of Medicinal Chemistry. 55: 7998-8006. PMID 22954387 DOI: 10.1021/jm300804e  0.56
2012 Leung CH, Zhong HJ, Yang H, Cheng Z, Chan DS, Ma VP, Abagyan R, Wong CY, Ma DL. A metal-based inhibitor of tumor necrosis factor-α. Angewandte Chemie (International Ed. in English). 51: 9010-4. PMID 22807261 DOI: 10.1002/anie.201202937  0.56
2012 Chan FY, Neves MA, Sun N, Tsang MW, Leung YC, Chan TH, Abagyan R, Wong KY. Validation of the AmpC β-lactamase binding site and identification of inhibitors with novel scaffolds. Journal of Chemical Information and Modeling. 52: 1367-75. PMID 22559726 DOI: 10.1021/ci300068m  0.56
2012 Tosh DK, Phan K, Gao ZG, Gakh AA, Xu F, Deflorian F, Abagyan R, Stevens RC, Jacobson KA, Katritch V. Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. Journal of Medicinal Chemistry. 55: 4297-308. PMID 22486652 DOI: 10.1021/jm300095s  0.56
2012 Cawston EE, Lam PC, Harikumar KG, Dong M, Ball AM, Augustine ML, Akgün E, Portoghese PS, Orry A, Abagyan R, Sexton PM, Miller LJ. Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor. The Journal of Biological Chemistry. 287: 18618-35. PMID 22467877 DOI: 10.1074/jbc.M111.335646  0.56
2012 JaroÅ„czyk M, WoÅ‚osewicz K, Gabrielsen M, Nowak G, Kufareva I, Mazurek AP, Ravna AW, Abagyan R, Bojarski AJ, Sylte I, Chilmonczyk Z. Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors. European Journal of Medicinal Chemistry. 49: 200-10. PMID 22309909 DOI: 10.1016/j.ejmech.2012.01.012  0.56
2011 Kufareva I, Rueda M, Katritch V, Stevens RC, Abagyan R. Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment. Structure (London, England : 1993). 19: 1108-26. PMID 21827947 DOI: 10.1016/j.str.2011.05.012  0.56
2011 Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S. Structure of the human histamine H1 receptor complex with doxepin. Nature. 475: 65-70. PMID 21697825 DOI: 10.1038/nature10236  0.56
2011 Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ. Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore. The Journal of Biological Chemistry. 286: 23888-99. PMID 21566140 DOI: 10.1074/jbc.M111.245969  0.56
2011 Miller LJ, Chen Q, Lam PC, Pinon DI, Sexton PM, Abagyan R, Dong M. Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling. The Journal of Biological Chemistry. 286: 15895-907. PMID 21454562 DOI: 10.1074/jbc.M110.217901  0.56
2011 Leung CH, Chan DS, Yang H, Abagyan R, Lee SM, Zhu GY, Fong WF, Ma DL. A natural product-like inhibitor of NEDD8-activating enzyme. Chemical Communications (Cambridge, England). 47: 2511-3. PMID 21240405 DOI: 10.1039/c0cc04927a  0.56
2010 Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (New York, N.Y.). 330: 1066-71. PMID 20929726 DOI: 10.1126/science.1194396  0.56
2010 Wacker D, Fenalti G, Brown MA, Katritch V, Abagyan R, Cherezov V, Stevens RC. Conserved binding mode of human beta2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography. Journal of the American Chemical Society. 132: 11443-5. PMID 20669948 DOI: 10.1021/ja105108q  0.56
2010 Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H, Larocca C, Saldanha SA, Abagyan R, Sun Y, Meyers DJ, et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chemistry & Biology. 17: 471-82. PMID 20534345 DOI: 10.1016/j.chembiol.2010.03.006  0.56
2010 Cheltsov AV, Aoyagi M, Aleshin A, Yu EC, Gilliland T, Zhai D, Bobkov AA, Reed JC, Liddington RC, Abagyan R. Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. Journal of Medicinal Chemistry. 53: 3899-906. PMID 20441222 DOI: 10.1021/jm901446n  0.56
2010 Chan DS, Lee HM, Yang F, Che CM, Wong CC, Abagyan R, Leung CH, Ma DL. Structure-based discovery of natural-product-like TNF-α inhibitors. Angewandte Chemie (International Ed. in English). 49: 2860-4. PMID 20235259 DOI: 10.1002/anie.200907360  0.56
2010 Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ. Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment. The Journal of Biological Chemistry. 285: 9919-31. PMID 20100828 DOI: 10.1074/jbc.M109.089730  0.56
2010 Katritch V, Jaakola VP, Lane JR, Lin J, Ijzerman AP, Yeager M, Kufareva I, Stevens RC, Abagyan R. Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. Journal of Medicinal Chemistry. 53: 1799-809. PMID 20095623 DOI: 10.1021/jm901647p  0.56
2010 Chow KH, Sun RW, Lam JB, Li CK, Xu A, Ma DL, Abagyan R, Wang Y, Che CM. A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathway. Cancer Research. 70: 329-37. PMID 19996284 DOI: 10.1158/0008-5472.CAN-09-3324  0.56
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