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Marylyn D. Ritchie - Publications

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401 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hou B, Wen Z, Bao J, Zhang R, Tong B, Yang S, Wen J, Cui Y, Moore JH, Saykin AJ, Huang H, Thompson PM, Ritchie MD, Davatzikos C, Shen L. Interpretable deep clustering survival machines for Alzheimer's disease subtype discovery. Medical Image Analysis. 97: 103231. PMID 38941858 DOI: 10.1016/j.media.2024.103231  0.524
2024 Hou B, Mondragón A, Tarzanagh DA, Zhou Z, Saykin AJ, Moore JH, Ritchie MD, Long Q, Shen L. PFERM: A Fair Empirical Risk Minimization Approach with Prior Knowledge. Amia Joint Summits On Translational Science Proceedings. Amia Joint Summits On Translational Science. 2024: 211-220. PMID 38827072  0.503
2024 Kumar R, Venkatesh R, Ritchie MD. SABER: Statistical Identification of Loci of Interest in GWAS Summary Statistics using a Bayesian Gaussian Mixture Model. Amia Joint Summits On Translational Science Proceedings. Amia Joint Summits On Translational Science. 2024: 575-583. PMID 38827044  0.377
2024 Romano JD, Truong V, Kumar R, Venkatesan M, Graham BE, Hao Y, Matsumoto N, Li X, Wang Z, Ritchie MD, Shen L, Moore JH. The Alzheimer's Knowledge Base: A Knowledge Graph for Alzheimer Disease Research. Journal of Medical Internet Research. 26: e46777. PMID 38635981 DOI: 10.2196/46777  0.778
2024 Li R, Benz L, Duan R, Denny JC, Hakonarson H, Mosley JD, Smoller JW, Wei WQ, Ritchie MD, Moore JH, Chen Y. mixWAS: An efficient distributed algorithm for mixed-outcomes genome-wide association studies. Medrxiv : the Preprint Server For Health Sciences. PMID 38260403 DOI: 10.1101/2024.01.09.24301073  0.848
2024 Verma SS, Gudiseva HV, Chavali VRM, Salowe RJ, Bradford Y, Guare L, Lucas A, Collins DW, Vrathasha V, Nair RM, Rathi S, Zhao B, He J, Lee R, Zenebe-Gete S, ... ... Ritchie MD, et al. A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma. Cell. 187: 464-480.e10. PMID 38242088 DOI: 10.1016/j.cell.2023.12.006  0.661
2023 Tong B, Zhou Z, Tarzanagh DA, Hou B, Saykin AJ, Moore J, Ritchie M, Shen L. Class-Balanced Deep Learning with Adaptive Vector Scaling Loss for Dementia Stage Detection. Machine Learning in Medical Imaging. Mlmi (Workshop). 14349: 144-154. PMID 38463442 DOI: 10.1007/978-3-031-45676-3_15  0.495
2023 Kember RL, Verma SS, Verma A, Xiao B, Lucas A, Kripke CM, Judy R, Chen J, Damrauer SM, Rader DJ, Ritchie MD. Polygenic risk scores for cardiometabolic traits demonstrate importance of ancestry for predictive precision medicine. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 29: 611-626. PMID 38160310  0.756
2023 Yang G, González P, Moneró M, Carrasquillo K, Renta JY, Hernandez-Suarez DF, Botton MR, Melin K, Scott SA, Ruaño G, Roche-Lima A, Alarcon C, Ritchie MD, Perera MA, Duconge J. Discovery of Ancestry-specific Variants Associated with Clopidogrel Response among Caribbean Hispanics. Medrxiv : the Preprint Server For Health Sciences. PMID 37873439 DOI: 10.1101/2023.09.29.23296372  0.317
2023 Roychowdhury T, Klarin D, Levin MG, Spin JM, Rhee YH, Deng A, Headley CA, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, ... ... Ritchie MD, et al. Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. Nature Genetics. PMID 37845353 DOI: 10.1038/s41588-023-01510-y  0.706
2023 Li B, Sangkuhl K, Whaley R, Woon M, Keat K, Whirl-Carrillo M, Ritchie MD, Klein TE. Frequencies of pharmacogenomic alleles across biogeographic groups in a large-scale biobank. American Journal of Human Genetics. 110: 1628-1647. PMID 37757824 DOI: 10.1016/j.ajhg.2023.09.001  0.775
2023 Pividori M, Lu S, Li B, Su C, Johnson ME, Wei WQ, Feng Q, Namjou B, Kiryluk K, Kullo IJ, Luo Y, Sullivan BD, Voight BF, Skarke C, Ritchie MD, et al. Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms. Nature Communications. 14: 5562. PMID 37689782 DOI: 10.1038/s41467-023-41057-4  0.828
2023 Safonov A, Nomakuchi TT, Chao E, Horton C, Dolinsky JS, Yussuf A, Richardson M, Speare V, Li S, Bogus ZC, Bonanni M, Raper A, Kallish S, Ritchie MD, Nathanson KL, et al. A genotype-first approach identifies high incidence of pathogenic variants with distinct disease associations. Medrxiv : the Preprint Server For Health Sciences. PMID 37609227 DOI: 10.1101/2023.08.08.23293676  0.323
2023 Lee DSM, DePaolo JS, Aragam KG, Biddinger K, Conery M, Dilitikas O, Hoffman-Andrews L, Judy RL, Khan A, Kulo I, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P, Arany ZP, ... ... Ritchie MD, et al. Common- and rare-variant genetic architecture of heart failure across the allele frequency spectrum. Medrxiv : the Preprint Server For Health Sciences. PMID 37503172 DOI: 10.1101/2023.07.16.23292724  0.377
2023 Singhal P, Guare L, Morse C, Lucas A, Byrska-Bishop M, Guerraty MA, Kim D, Ritchie MD, Verma A. DETECT: Feature extraction method for disease trajectory modeling in electronic health records. Amia Joint Summits On Translational Science Proceedings. Amia Joint Summits On Translational Science. 2023: 487-496. PMID 37350926  0.792
2023 Wang X, Feng Y, Tong B, Bao J, Ritchie MD, Saykin AJ, Moore JH, Urbanowicz R, Shen L. Exploring Automated Machine Learning for Cognitive Outcome Prediction from Multimodal Brain Imaging using STREAMLINE. Amia Joint Summits On Translational Science Proceedings. Amia Joint Summits On Translational Science. 2023: 544-553. PMID 37350896  0.714
2023 Tong B, Risacher SL, Bao J, Feng Y, Wang X, Ritchie MD, Moore JH, Urbanowicz R, Saykin AJ, Shen L. Comparing Amyloid Imaging Normalization Strategies for Alzheimer's Disease Classification using an Automated Machine Learning Pipeline. Amia Joint Summits On Translational Science Proceedings. Amia Joint Summits On Translational Science. 2023: 525-533. PMID 37350880  0.717
2023 Verma SS, Guare L, Ehsan S, Gastounioti A, Scales G, Ritchie MD, Kontos D, McCarthy AM. Genome-Wide Association Study of Breast Density among Women of African Ancestry. Cancers. 15. PMID 37345113 DOI: 10.3390/cancers15102776  0.581
2023 Klarin D, Devineni P, Sendamarai AK, Angueira AR, Graham SE, Shen YH, Levin MG, Pirruccello JP, Surakka I, Karnam PR, Roychowdhury T, Li Y, Wang M, Aragam KG, Paruchuri K, ... ... Ritchie MD, et al. Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program. Nature Genetics. PMID 37308786 DOI: 10.1038/s41588-023-01420-z  0.662
2023 Zaidi AA, Verma A, Morse C, Ritchie MD, Mathieson I. The genetic and phenotypic correlates of mtDNA copy number in a multi-ancestry cohort. Hgg Advances. 4: 100202. PMID 37255673 DOI: 10.1016/j.xhgg.2023.100202  0.623
2023 Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, ... ... Ritchie MD, et al. Author Correction: The power of genetic diversity in genome-wide association studies of lipids. Nature. PMID 37237109 DOI: 10.1038/s41586-023-06194-2  0.819
2023 Singhal P, Verma SS, Ritchie MD. Gene Interactions in Human Disease Studies-Evidence Is Mounting. Annual Review of Biomedical Data Science. PMID 37196359 DOI: 10.1146/annurev-biodatasci-102022-120818  0.691
2023 Singhal P, Veturi Y, Dudek SM, Lucas A, Frase A, van Steen K, Schrodi SJ, Fasel D, Weng C, Pendergrass R, Schaid DJ, Kullo IJ, Dikilitas O, Sleiman PMA, Hakonarson H, ... ... Ritchie MD, et al. Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets. American Journal of Human Genetics. 110: 575-591. PMID 37028392 DOI: 10.1016/j.ajhg.2023.03.007  0.787
2023 Xiao B, Velez Edwards DR, Lucas A, Drivas T, Gray K, Keating B, Weng C, Jarvik GP, Hakonarson H, Kottyan L, Elhadad N, Wei WQ, Luo Y, Kim D, Ritchie M, et al. Inference of Causal Relationships Between Genetic Risk Factors for Cardiometabolic Phenotypes and Female-Specific Health Conditions. Journal of the American Heart Association. e026561. PMID 36846987 DOI: 10.1161/JAHA.121.026561  0.785
2023 Hui D, Mehrabi S, Quimby AE, Chen T, Chen S, Park J, Li B, Ruckenstein MJ, Rader DJ, Ritchie MD, Brant JA, Epstein DJ, Mathieson I. Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort. Plos Genetics. 19: e1010584. PMID 36656851 DOI: 10.1371/journal.pgen.1010584  0.776
2022 Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN, Lo Faro V, Lopera-Maya EA, Läll K, ... ... Ritchie MD, et al. Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease. Cell Genomics. 2: 100192. PMID 36777996 DOI: 10.1016/j.xgen.2022.100192  0.65
2022 Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, ... ... Ritchie MD, et al. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. Genome Biology. 23: 268. PMID 36575460 DOI: 10.1186/s13059-022-02837-1  0.804
2022 Verma A, Damrauer SM, Naseer N, Weaver J, Kripke CM, Guare L, Sirugo G, Kember RL, Drivas TG, Dudek SM, Bradford Y, Lucas A, Judy R, Verma SS, Meagher E, ... ... Ritchie MD, et al. The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population. Journal of Personalized Medicine. 12. PMID 36556195 DOI: 10.3390/jpm12121974  0.742
2022 Hui D, Xiao B, Dikilitas O, Freimuth RR, Irvin MR, Jarvik GP, Kottyan L, Kullo I, Limdi NA, Liu C, Luo Y, Namjou B, Puckelwartz MJ, Schaid D, Tiwari H, ... ... Ritchie MD, et al. Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 28: 437-448. PMID 36540998  0.783
2022 Park J, MacLean MT, Lucas AM, Torigian DA, Schneider CV, Cherlin T, Xiao B, Miller JE, Bradford Y, Judy RL, Verma A, Damrauer SM, Ritchie MD, Witschey WR, Rader DJ. Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank. Cell Reports. Medicine. 100855. PMID 36513072 DOI: 10.1016/j.xcrm.2022.100855  0.805
2022 Verma SS, Keat K, Li B, Hoffecker G, Risman M, Sangkuhl K, Whirl-Carrillo M, Dudek S, Verma A, Klein TE, Ritchie MD, Tuteja S. Evaluating the frequency and the impact of pharmacogenetic alleles in an ancestrally diverse Biobank population. Journal of Translational Medicine. 20: 550. PMID 36443877 DOI: 10.1186/s12967-022-03745-5  0.806
2022 Truong VQ, Woerner JA, Cherlin TA, Bradford Y, Lucas AM, Okeh CC, Shivakumar MK, Hui DH, Kumar R, Pividori M, Jones SC, Bossa AC, Turner SD, Ritchie MD, Verma SS. Quality Control Procedures for Genome-Wide Association Studies. Current Protocols. 2: e603. PMID 36441943 DOI: 10.1002/cpz1.603  0.742
2022 Li B, Sangkuhl K, Keat K, Whaley RM, Woon M, Verma S, Dudek S, Tuteja S, Verma A, Whirl-Carrillo M, Ritchie MD, Klein TE. How to Run the Pharmacogenomics Clinical Annotation Tool (PharmCAT). Clinical Pharmacology and Therapeutics. PMID 36350094 DOI: 10.1002/cpt.2790  0.817
2022 Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU, Jiang Y, Raghavan S, Miao J, Arias JD, Graham SE, Mukamel RE, Spracklen CN, ... ... Ritchie MD, et al. A saturated map of common genetic variants associated with human height. Nature. PMID 36224396 DOI: 10.1038/s41586-022-05275-y  0.84
2022 Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL, Chesi A, Wells A, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, ... ... Ritchie MD, et al. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids. American Journal of Human Genetics. 109: 1366-1387. PMID 35931049 DOI: 10.1016/j.ajhg.2022.06.012  0.817
2022 Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S, Lee KM, Fang H, Chen F, Lu Y, Tsao NL, Raghavan S, Koyama S, Gorman BR, Vujkovic M, ... ... Ritchie MD, et al. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nature Medicine. PMID 35915156 DOI: 10.1038/s41591-022-01891-3  0.658
2022 Chen BY, Bone WP, Lorenz K, Levin M, Ritchie MD, Voight BF. ColocQuiaL: A QTL-GWAS colocalization pipeline. Bioinformatics (Oxford, England). PMID 35894642 DOI: 10.1093/bioinformatics/btac512  0.328
2022 Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Papenberg BW, Zahoor MA, Mirabello L, Ring TJ, Lee CH, Albert PS, Andreakos E, Arons E, Barsh G, Biesecker LG, Boyle DL, ... ... Ritchie MD, et al. Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries. Nature Genetics. PMID 35835913 DOI: 10.1038/s41588-022-01113-z  0.597
2022 Zhang X, Lucas AM, Veturi Y, Drivas TG, Bone WP, Verma A, Chung WK, Crosslin D, Denny JC, Hebbring S, Jarvik GP, Kullo I, Larson EB, Rasmussen-Torvik LJ, Schaid DJ, ... ... Ritchie MD, et al. Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders. Nature Communications. 13: 3428. PMID 35701404 DOI: 10.1038/s41467-022-30678-w  0.684
2022 Tcheandjieu C, Xiao K, Tejeda H, Lynch JA, Ruotsalainen S, Bellomo T, Palnati M, Judy R, Klarin D, Kember RL, Verma S, Palotie A, Daly M, Ritchie M, Rader DJ, et al. High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease. Nature Genetics. 54: 772-782. PMID 35637384 DOI: 10.1038/s41588-022-01070-7  0.583
2022 Zhang C, Verma A, Feng Y, Melo MCR, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel MA, Campbell MC, Beggs W, Hirbo J, Wata Mpoloka S, ... ... Ritchie MD, et al. Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection. Proceedings of the National Academy of Sciences of the United States of America. 119: e2123000119. PMID 35580180 DOI: 10.1073/pnas.2123000119  0.606
2022 Verma A, Tsao NL, Thomann LO, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford DC, Efird JT, Huffman JE, Hung A, Ivey KL, Levin MG, Lynch J, Natarajan P, ... ... Ritchie MD, et al. A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. Plos Genetics. 18: e1010113. PMID 35482673 DOI: 10.1371/journal.pgen.1010113  0.633
2022 Chand GB, Singhal P, Dwyer DB, Wen J, Erus G, Doshi J, Srinivasan D, Mamourian E, Varol E, Sotiras A, Hwang G, Dazzan P, Kahn RS, Schnack HG, Zanetti MV, ... ... Ritchie MD, et al. Schizophrenia Imaging Signatures and Their Associations With Cognition, Psychopathology, and Genetics in the General Population. The American Journal of Psychiatry. appiajp21070686. PMID 35410495 DOI: 10.1176/appi.ajp.21070686  0.501
2022 Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, ... ... Ritchie MD, et al. Whole genome sequencing reveals host factors underlying critical Covid-19. Nature. PMID 35255492 DOI: 10.1038/s41586-022-04576-6  0.603
2022 Horowitz JE, Kosmicki JA, Damask A, Sharma D, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Yadav A, Leader JB, Marcketta A, Park DS, Lanche R, Maxwell E, Knight SC, ... ... Ritchie MD, et al. Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease. Nature Genetics. PMID 35241825 DOI: 10.1038/s41588-021-01006-7  0.61
2022 Bellomo TR, Bone WP, Chen BY, Gawronski KAB, Zhang D, Park J, Levin M, Tsao N, Klarin D, Lynch J, Assimes TL, Gaziano JM, Wilson PW, Cho K, Vujkovic M, ... ... Ritchie MD, et al. Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci. Frontiers in Genetics. 12: 787545. PMID 35186008 DOI: 10.3389/fgene.2021.787545  0.325
2021 Wang L, Desai H, Verma SS, Le A, Hausler R, Verma A, Judy R, Doucette A, Gabriel PE, Nathanson KL, Damrauer SM, Mowery DL, Ritchie MD, Kember RL, et al. Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 34906489 DOI: 10.1016/j.gim.2021.10.015  0.727
2021 Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, ... ... Ritchie MD, et al. The power of genetic diversity in genome-wide association studies of lipids. Nature. PMID 34887591 DOI: 10.1038/s41586-021-04064-3  0.836
2021 Li B, Ritchie MD. From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries. Frontiers in Genetics. 12: 713230. PMID 34659337 DOI: 10.3389/fgene.2021.713230  0.826
2021 Verma A, Tsao NL, Thomann L, Ho YL, Iyengar SK, Luoh SW, Carr R, Crawford D, Efird JT, Huffman J, Hung A, Ivey KL, Levin M, Lynch J, Natarajan P, ... ... Ritchie MD, et al. A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program. Medrxiv : the Preprint Server For Health Sciences. PMID 34642702 DOI: 10.1101/2021.05.18.21257396  0.636
2021 Hartwell EE, Merikangas AK, Verma SS, Ritchie MD, Kranzler HR, Kember RL. Genetic liability for substance use associated with medical comorbidities in electronic health records of African- and European-ancestry individuals. Addiction Biology. e13099. PMID 34611967 DOI: 10.1111/adb.13099  0.638
2021 Liu X, Verma A, Garcia G, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, et al. Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34593624 DOI: 10.1073/pnas.2113401118  0.479
2021 Park J, Packard EA, Levin MG, Judy RL, Damrauer SM, Day SM, Ritchie MD, Rader DJ. A genome-first approach to rare variants in hypertrophic cardiomyopathy genes MYBPC3 and MYH7 in a medical biobank. Human Molecular Genetics. PMID 34542152 DOI: 10.1093/hmg/ddab249  0.394
2021 Zhang C, Verma A, Feng Y, Melo MCDR, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel M, Campbell M, Beggs W, Hirbo J, Mpoloka SW, ... ... Ritchie M, et al. Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection. Research Square. PMID 34341784 DOI: 10.21203/rs.3.rs-673011/v1  0.619
2021 Holmes JH, Beinlich J, Boland MR, Bowles KH, Chen Y, Cook TS, Demiris G, Draugelis M, Fluharty L, Gabriel PE, Grundmeier R, Hanson CW, Herman DS, Himes BE, Hubbard RA, ... ... Ritchie MD, et al. Why Is the Electronic Health Record So Challenging for Research and Clinical Care? Methods of Information in Medicine. PMID 34282602 DOI: 10.1055/s-0041-1731784  0.781
2021 Banday AR, Stanifer ML, Florez-Vargas O, Onabajo OO, Zahoor MA, Papenberg BW, Ring TJ, Lee CH, Andreakos E, Arons E, Barsh G, Biesecker LG, Boyle DL, Burnett-Hartman A, Carrington M, ... ... Ritchie MD, et al. Genetic regulation of nonsense-mediated decay underlies association with risk of severe COVID-19. Medrxiv : the Preprint Server For Health Sciences. PMID 34282422 DOI: 10.1101/2021.07.09.21260221  0.615
2021 Ahmadmehrabi S, Li B, Hui D, Park J, Ritchie M, Rader DJ, Ruckenstein MJ, Epstein DJ, Brant J. A Genome-First Approach to Rare Variants in Dominant Postlingual Hearing Loss Genes in a Large Adult Population. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 1945998211029544. PMID 34281439 DOI: 10.1177/01945998211029544  0.765
2021 Zhang C, Verma A, Feng Y, Melo MCR, McQuillan M, Hansen M, Lucas A, Park J, Ranciaro A, Thompson S, Rubel MA, Campbell MC, Beggs W, Hirbo J, Mpoloka SW, ... ... Ritchie MD, et al. Global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection. Medrxiv : the Preprint Server For Health Sciences. PMID 34230933 DOI: 10.1101/2021.06.28.21259529  0.622
2021 Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E, Verma A, Miller JE, Kullo I, Hakonarson H, Sleiman P, Schaid D, Stein CM, Edwards DRV, Feng Q, ... ... Ritchie MD, et al. A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts. Nature Genetics. PMID 34140684 DOI: 10.1038/s41588-021-00879-y  0.814
2021 Sun L, Surya S, Goodman NG, Le AN, Kelly G, Owoyemi O, Desai H, Zheng C, DeLuca S, Good ML, Hussain J, Jeffries SD, Kry YR, Kugler EM, Mansour M, ... ... Ritchie M, et al. SARS-CoV-2 Seropositivity and Seroconversion in Patients Undergoing Active Cancer-Directed Therapy. Jco Oncology Practice. OP2100113. PMID 34133219 DOI: 10.1200/OP.21.00113  0.654
2021 Kosmicki JA, Horowitz JE, Banerjee N, Lanche R, Marcketta A, Maxwell E, Bai X, Sun D, Backman JD, Sharma D, Kury FSP, Kang HM, O'Dushlaine C, Yadav A, Mansfield AJ, ... ... Ritchie MD, et al. Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals. American Journal of Human Genetics. PMID 34115965 DOI: 10.1016/j.ajhg.2021.05.017  0.651
2021 Hall MA, Wallace J, Lucas AM, Bradford Y, Verma SS, Müller-Myhsok B, Passero K, Zhou J, McGuigan J, Jiang B, Pendergrass SA, Zhang Y, Peissig P, Brilliant M, Sleiman P, ... ... Ritchie MD, et al. Novel EDGE encoding method enhances ability to identify genetic interactions. Plos Genetics. 17: e1009534. PMID 34086673 DOI: 10.1371/journal.pgen.1009534  0.831
2021 Li B, Veturi Y, Verma A, Bradford Y, Daar ES, Gulick RM, Riddler SA, Robbins GK, Lennox JL, Haas DW, Ritchie MD. Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adults. Plos Genetics. 17: e1009464. PMID 33901188 DOI: 10.1371/journal.pgen.1009464  0.808
2021 Shang N, Khan A, Polubriaginof F, Zanoni F, Mehl K, Fasel D, Drawz PE, Carrol RJ, Denny JC, Hathcock MA, Arruda-Olson AM, Peissig PL, Dart RA, Brilliant MH, Larson EB, ... ... Ritchie MD, et al. Medical records-based chronic kidney disease phenotype for clinical care and "big data" observational and genetic studies. Npj Digital Medicine. 4: 70. PMID 33850243 DOI: 10.1038/s41746-021-00428-1  0.797
2021 Ahmadmehrabi S, Li B, Park J, Devkota B, Vujkovic M, Ko YA, Van Wagoner D, Tang WHW, Krantz I, Ritchie M, Brant J, Ruckenstein MJ, Epstein DJ, Rader DJ. Genome-first approach to rare EYA4 variants and cardio-auditory phenotypes in adults. Human Genetics. PMID 33745059 DOI: 10.1007/s00439-021-02263-6  0.808
2021 Georgakis MK, Malik R, Li X, Gill D, Levin MG, Vy HMT, Judy R, Ritchie M, Verma SS, Nadkarni GN, Damrauer SM, Theodoratou E, Dichgans M. Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile: A Phenome-Wide Association Study. Circulation. 143: 1177-1180. PMID 33720771 DOI: 10.1161/CIRCULATIONAHA.120.052604  0.64
2021 Liu X, Verma A, Ramage H, Garcia G, Myers RL, Lucas A, Michaelson JJ, Coryell W, Kumar A, Charney A, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Damoiseaux R, et al. Targeting the Coronavirus Nucleocapsid Protein through GSK-3 Inhibition. Medrxiv : the Preprint Server For Health Sciences. PMID 33655282 DOI: 10.1101/2021.02.17.21251933  0.482
2021 Drivas TG, Lucas A, Zhang X, Ritchie MD. Mendelian pathway analysis of laboratory traits reveals distinct roles for ciliary subcompartments in common disease pathogenesis. American Journal of Human Genetics. PMID 33636100 DOI: 10.1016/j.ajhg.2021.02.008  0.576
2021 Sun L, Surya S, Le AN, Desai H, Doucette A, Gabriel P, Ritchie MD, Rader D, Maillard I, Bange E, Huang AC, Vonderheide RH, DeMichele A, Verma A, Mamtani R, et al. Rates of COVID-19-Related Outcomes in Cancer Compared With Noncancer Patients. Jnci Cancer Spectrum. 5: pkaa120. PMID 33554040 DOI: 10.1093/jncics/pkaa120  0.492
2021 Sun L, Surya S, Goodman NG, Le AN, Kelly G, Owoyemi O, Desai H, Zheng C, DeLuca S, Good ML, Hussain J, Jeffries SD, Kry YR, Kugler EM, Mansour M, ... ... Ritchie M, et al. SARS-CoV-2 seropositivity and seroconversion in patients undergoing active cancer-directed therapy. Medrxiv : the Preprint Server For Health Sciences. PMID 33469597 DOI: 10.1101/2021.01.15.21249810  0.662
2021 Park J, Lucas AM, Zhang X, Chaudhary K, Cho JH, Nadkarni G, Dobbyn A, Chittoor G, Josyula NS, Katz N, Breeyear JH, Ahmadmehrabi S, Drivas TG, Chavali VRM, Fasolino M, ... ... Ritchie MD, et al. Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations. Nature Medicine. PMID 33432171 DOI: 10.1038/s41591-020-1133-8  0.781
2021 Li R, Duan R, Zhang X, Lumley T, Pendergrass S, Bauer C, Hakonarson H, Carrell DS, Smoller JW, Wei WQ, Carroll R, Velez Edwards DR, Wiesner G, Sleiman P, Denny JC, ... ... Ritchie MD, et al. Lossless integration of multiple electronic health records for identifying pleiotropy using summary statistics. Nature Communications. 12: 168. PMID 33420026 DOI: 10.1038/s41467-020-20211-2  0.805
2020 Zhang X, Li R, Ritchie MD. Statistical Impact of Sample Size and Imbalance on Multivariate Analysis and A Case Study in the UK Biobank. Amia ... Annual Symposium Proceedings. Amia Symposium. 2020: 1383-1391. PMID 33936514  0.837
2020 Levin MG, Judy R, Gill D, Vujkovic M, Verma SS, Bradford Y, Ritchie MD, Hyman MC, Nazarian S, Rader DJ, Voight BF, Damrauer SM. Genetics of height and risk of atrial fibrillation: A Mendelian randomization study. Plos Medicine. 17: e1003288. PMID 33031386 DOI: 10.1371/journal.pmed.1003288  0.58
2020 Klarin D, Verma SS, Judy R, Dikilitas O, Wolford BN, Paranjpe I, Levin MG, Pan C, Tcheandjieu C, Spin JM, Lynch J, Assimes TL, Nyrønning LÅ, Mattsson E, Edwards TL, ... ... Ritchie M, et al. Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation. PMID 32981348 DOI: 10.1161/CIRCULATIONAHA.120.047544  0.648
2020 Bergmeijer TO, Yasmina A, Vos GJA, Janssen PWA, Hackeng CM, Kelder JC, Verma SS, Ritchie MD, Gong L, Klein TE, de Boer A, Klungel OH, Ten Berg JM, Deneer VHM. Effect of *22 and Genetic Variants on Platelet Reactivity in Patients Treated with Clopidogrel and Lipid-Lowering Drugs Undergoing Elective Percutaneous Coronary Intervention. Genes. 11. PMID 32932966 DOI: 10.3390/genes11091068  0.594
2020 Kember RL, Merikangas AK, Verma SS, Verma A, Judy R, Damrauer SM, Ritchie MD, Rader DJ, Bućan M. Polygenic Risk of Psychiatric Disorders Exhibits Cross-trait Associations in Electronic Health Record Data From European Ancestry Individuals. Biological Psychiatry. PMID 32919613 DOI: 10.1016/J.Biopsych.2020.06.026  0.726
2020 Sun L, Sanjna S, Le A, Desai H, Doucette A, Gabriel P, Ritchie M, Rader D, Maillard I, Bange E, Huang A, Vonderheide RH, DeMichele A, Verma A, Mamtani R, et al. Rates of COVID-19-related Outcomes in Cancer compared to non-Cancer Patients. Medrxiv : the Preprint Server For Health Sciences. PMID 32817956 DOI: 10.1101/2020.08.14.20174961  0.483
2020 Verma SS, Bergmeijer TO, Gong L, Reny JL, Lewis JP, Mitchell BD, Alexopoulos D, Aradi D, Altman RB, Bliden K, Bradford Y, Campo G, Chang K, Cleator JH, Déry JP, ... ... Ritchie MD, et al. Genome-wide association study of platelet reactivity and cardiovascular response in patients treated with clopidogrel: a study by the International Clopidogrel Pharmacogenomics Consortium (ICPC). Clinical Pharmacology and Therapeutics. PMID 32472697 DOI: 10.1002/Cpt.1911  0.651
2020 Moore JH, Barnett I, Boland MR, Chen Y, Demiris G, Gonzalez-Hernandez G, Herman DS, Himes BE, Hubbard RA, Kim D, Morris JS, Mowery DL, Ritchie MD, Shen L, Urbanowicz R, et al. Ideas for how informaticians can get involved with COVID-19 research. Biodata Mining. 13: 3. PMID 32419848 DOI: 10.1186/S13040-020-00213-Y  0.776
2020 Murray MF, Kenny EE, Ritchie MD, Rader DJ, Bale AE, Giovanni MA, Abul-Husn NS. COVID-19 outcomes and the human genome. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 32393819 DOI: 10.1038/S41436-020-0832-3  0.301
2020 Li R, Chen Y, Ritchie MD, Moore JH. Electronic health records and polygenic risk scores for predicting disease risk. Nature Reviews. Genetics. PMID 32235907 DOI: 10.1038/S41576-020-0224-1  0.818
2020 Joo YY, Actkins K, Pacheco JA, Basile AO, Carroll R, Crosslin DR, Day F, Denny JC, Velez Edwards DR, Hakonarson H, Harley JB, Hebbring SJ, Ho K, Jarvik GP, Jones M, ... ... Ritchie MD, et al. A polygenic and phenotypic risk prediction for Polycystic Ovary Syndrome evaluated by Phenome-wide association studies. The Journal of Clinical Endocrinology and Metabolism. PMID 31917831 DOI: 10.1210/Clinem/Dgz326  0.783
2020 Ritchie MD, Moore JH, Kim JH. Translational Bioinformatics: Biobanks in the Precision Medicine Era. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 25: 743-747. PMID 31797645  0.518
2019 Lucas AM, Palmiero NE, McGuigan J, Passero K, Zhou J, Orie D, Ritchie MD, Hall MA. CLARITE Facilitates the Quality Control and Analysis Process for EWAS of Metabolic-Related Traits. Frontiers in Genetics. 10: 1240. PMID 31921293 DOI: 10.3389/Fgene.2019.01240  0.752
2019 Pendergrass SA, Buyske S, Jeff JM, Frase A, Dudek S, Bradford Y, Ambite JL, Avery CL, Buzkova P, Deelman E, Fesinmeyer MD, Haiman C, Heiss G, Hindorff LA, Hsu CN, ... ... Ritchie MD, et al. A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. Plos One. 14: e0226771. PMID 31891604 DOI: 10.1371/Journal.Pone.0226771  0.806
2019 Damrauer SM, Chaudhary K, Cho JH, Liang LW, Argulian E, Chan L, Dobbyn A, Guerraty MA, Judy R, Kay J, Kember RL, Levin MG, Saha A, Van Vleck T, Verma SS, ... ... Ritchie M, et al. Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry. Jama. 322: 2191-2202. PMID 31821430 DOI: 10.1001/Jama.2019.17935  0.639
2019 Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, ... ... Ritchie MD, et al. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. Bmc Cardiovascular Disorders. 19: 240. PMID 31664920 DOI: 10.1186/S12872-019-1187-Z  0.413
2019 Lewis JP, Backman JD, Reny JL, Bergmeijer TO, Mitchell BD, Ritchie MD, Déry JP, Pakyz RE, Gong L, Ryan K, Kim EY, Aradi D, Fernandez-Cadenas I, Lee MTM, Whaley RM, et al. Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients. European Heart Journal. Cardiovascular Pharmacotherapy. PMID 31504375 DOI: 10.1093/Ehjcvp/Pvz045  0.303
2019 Glessner JT, Li J, Desai A, Palmer M, Kim D, Lucas AM, Chang X, Connolly JJ, Almoguera B, Harley JB, Jarvik GP, Ritchie MD, Sleiman PMA, Roden DM, Crosslin D, et al. CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease. International Journal of Cardiology. PMID 31447229 DOI: 10.1016/J.Ijcard.2019.07.058  0.718
2019 Park J, Levin MG, Haggerty CM, Hartzel DN, Judy R, Kember RL, Reza N, Ritchie MD, Owens AT, Damrauer SM, Rader DJ. A genome-first approach to aggregating rare genetic variants in LMNA for association with electronic health record phenotypes. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 31383942 DOI: 10.1038/S41436-019-0625-8  0.474
2019 Manduchi E, Orzechowski PR, Ritchie MD, Moore JH. Exploration of a diversity of computational and statistical measures of association for genome-wide genetic studies. Biodata Mining. 12: 14. PMID 31320928 DOI: 10.1186/S13040-019-0201-4  0.673
2019 Namjou B, Lingren T, Huang Y, Parameswaran S, Cobb BL, Stanaway IB, Connolly JJ, Mentch FD, Benoit B, Niu X, Wei WQ, Carroll RJ, Pacheco JA, Harley ITW, Divanovic S, ... ... Ritchie MD, et al. GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. Bmc Medicine. 17: 135. PMID 31311600 DOI: 10.1186/S12916-019-1364-Z  0.663
2019 Sangkuhl K, Whirl-Carrillo M, Whaley RM, Woon M, Lavertu A, Altman RB, Carter L, Verma A, Ritchie MD, Klein TE. Pharmacogenomics Clinical Annotation Tool (PharmCAT). Clinical Pharmacology and Therapeutics. PMID 31306493 DOI: 10.1002/Cpt.1568  0.642
2019 Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Kirchner HL, Leader JB, Liang L, McDermott-Roe C, ... ... Ritchie MD, et al. Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants. Circulation. PMID 31216868 DOI: 10.1161/Circulationaha.119.039573  0.707
2019 Miller JE, Metpally RP, Person TN, Krishnamurthy S, Dasari VR, Shivakumar M, Lavage DR, Cook AM, Carey DJ, Ritchie MD, Kim D, Gogoi R. Correction to: Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population. Bmc Medical Genomics. 12: 65. PMID 31118041 DOI: 10.1186/S12920-019-0523-6  0.768
2019 Miller JE, Veturi Y, Ritchie MD. Innovative strategies for annotating the "relationSNP" between variants and molecular phenotypes. Biodata Mining. 12: 10. PMID 31114635 DOI: 10.1186/S13040-019-0197-9  0.794
2019 Miller JE, Metpally RP, Person TN, Krishnamurthy S, Dasari VR, Shivakumar M, Lavage DR, Cook AM, Carey DJ, Ritchie MD, Kim D, Gogoi R. Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population. Bmc Medical Genomics. 12: 59. PMID 31053132 DOI: 10.1186/S12920-019-0504-9  0.803
2019 Hellwege JN, Stallings S, Torstenson ES, Carroll R, Borthwick KM, Brilliant MH, Crosslin D, Gordon A, Hripcsak G, Jarvik GP, Linneman JG, Devi P, Peissig PL, Sleiman PAM, Hakonarson H, ... Ritchie MD, et al. Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network. Scientific Reports. 9: 6077. PMID 30988330 DOI: 10.1038/S41598-019-42427-Z  0.758
2019 Li B, Veturi Y, Bradford Y, Verma SS, Verma A, Lucas AM, Haas DW, Ritchie MD. Influence of tissue context on gene prioritization for predicted transcriptome-wide association studies. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 24: 296-307. PMID 30864331  0.812
2019 Zhang X, Veturi Y, Verma S, Bone W, Verma A, Lucas A, Hebbring S, Denny JC, Stanaway IB, Jarvik GP, Crosslin D, Larson EB, Rasmussen-Torvik L, Pendergrass SA, Smoller JW, ... ... Ritchie MD, et al. Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 24: 272-283. PMID 30864329  0.835
2019 Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, Larson EB, Scrol A, Jarvik GP, Crosslin DR, Leppig K, et al. A phenome-wide association study to discover pleiotropic effects of , , and . Npj Genomic Medicine. 4: 3. PMID 30774981 DOI: 10.1038/S41525-019-0078-7  0.792
2019 Moore JH, Boland MR, Camara PG, Chervitz H, Gonzalez G, Himes BE, Kim D, Mowery DL, Ritchie MD, Shen L, Urbanowicz RJ, Holmes JH. Preparing next-generation scientists for biomedical big data: artificial intelligence approaches. Personalized Medicine. PMID 30760118 DOI: 10.2217/Pme-2018-0145  0.788
2019 Zhang X, Basile AO, Pendergrass SA, Ritchie MD. Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico. Bmc Bioinformatics. 20: 46. PMID 30669967 DOI: 10.1186/S12859-018-2591-6  0.817
2019 Miller JE, Dudek SM, Frase AT, Ritchie MD. P4-486: EXPLORING RARE VARIATIONS THAT IMPACT REGIONS OF PROTEINS ASSOCIATED WITH ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P1498-P1498. DOI: 10.1016/J.Jalz.2019.08.032  0.74
2019 Kember R, Verma S, Verma A, Ritchie M, Damrauer S, Rader D, Merikangas A. USING ELECTRONIC HEALTH RECORDS TO IDENTIFY MEDICAL COMORBIDITIES OF MOOD DISORDERS European Neuropsychopharmacology. 29: S13-S14. DOI: 10.1016/J.Euroneuro.2019.07.028  0.687
2018 Verma A, Bang L, Miller JE, Zhang Y, Lee MTM, Zhang Y, Byrska-Bishop M, Carey DJ, Ritchie MD, Pendergrass SA, Kim D. Human-Disease Phenotype Map Derived from PheWAS across 38,682 Individuals. American Journal of Human Genetics. PMID 30598166 DOI: 10.1016/J.Ajhg.2018.11.006  0.834
2018 Mosley JD, Benson MD, Smith JG, Melander O, Ngo D, Shaffer CM, Ferguson JF, Herzig MS, McCarty CA, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, ... ... Ritchie MD, et al. Probing the Virtual Proteome to Identify Novel Disease Biomarkers. Circulation. 138: 2469-2481. PMID 30571344 DOI: 10.1161/Circulationaha.118.036063  0.632
2018 Verma SS, Josyula N, Verma A, Zhang X, Veturi Y, Dewey FE, Hartzel DN, Lavage DR, Leader J, Ritchie MD, Pendergrass SA. Author Correction: Rare variants in drug target genes contributing to complex diseases, phenome-wide. Scientific Reports. 8: 15911. PMID 30353015 DOI: 10.1038/S41598-018-27936-7  0.791
2018 Stanaway IB, Hall TO, Rosenthal EA, Palmer M, Naranbhai V, Knevel R, Namjou-Khales B, Carroll RJ, Kiryluk K, Gordon AS, Linder J, Howell KM, Mapes BM, Lin FTJ, Joo YY, ... ... Ritchie MD, et al. The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype. Genetic Epidemiology. PMID 30298529 DOI: 10.1002/Gepi.22167  0.78
2018 Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Jarvik GP, Gordon AS, Palmer MR, ... ... Ritchie MD, et al. A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers. Nature Communications. 9: 3522. PMID 30166544 DOI: 10.1038/S41467-018-05624-4  0.74
2018 van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, ... ... Ritchie MD, et al. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications. 9: 2904. PMID 30046033 DOI: 10.1038/S41467-018-04766-9  0.387
2018 Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P, Sidorenko J, Karlsson Linnér R, Fontana MA, Kundu T, Lee C, Li H, Li R, ... ... Ritchie MD, et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics. PMID 30038396 DOI: 10.1038/S41588-018-0147-3  0.679
2018 Gusarova V, O'Dushlaine C, Teslovich TM, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, ... ... Ritchie MD, et al. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature Communications. 9: 2252. PMID 29899519 DOI: 10.1038/S41467-018-04611-Z  0.319
2018 Ritchie MD, Van Steen K. The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological interpretation. Annals of Translational Medicine. 6: 157. PMID 29862246 DOI: 10.21037/Atm.2018.04.05  0.488
2018 Haas DW, Bradford Y, Verma A, Verma SS, Eron JJ, Gulick RM, Riddler SA, Sax PE, Daar ES, Morse GD, Acosta EP, Ritchie MD. Brain neurotransmitter transporter/receptor genomics and efavirenz central nervous system adverse events. Pharmacogenetics and Genomics. PMID 29847509 DOI: 10.1097/Fpc.0000000000000341  0.706
2018 Li R, Kim D, Wheeler HE, Dudek SM, Dolan ME, Ritchie MD. Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity. The Pharmacogenomics Journal. PMID 29795408 DOI: 10.1038/S41397-018-0024-6  0.84
2018 Verma SS, Lucas A, Zhang X, Veturi Y, Dudek S, Li B, Li R, Urbanowicz R, Moore JH, Kim D, Ritchie MD. Collective feature selection to identify crucial epistatic variants. Biodata Mining. 11: 5. PMID 29713383 DOI: 10.1186/S13040-018-0168-6  0.787
2018 Wei WQ, Li X, Feng Q, Kubo M, Kullo IJ, Peissig PL, Karlson EW, Jarvik GP, Lee MTM, Shang N, Larson EA, Edwards T, Shaffer C, Mosley JD, Maeda S, ... ... Ritchie M, et al. Variants are Associated with Residual Cardiovascular Risk in Patients Receiving Statins. Circulation. PMID 29703846 DOI: 10.1161/Circulationaha.117.031356  0.588
2018 Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, ... ... Ritchie MD, et al. Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC). American Heart Journal. 198: 152-159. PMID 29653637 DOI: 10.1016/J.Ahj.2017.12.010  0.368
2018 Verma A, Bradford Y, Dudek S, Lucas AM, Verma SS, Pendergrass SA, Ritchie MD. A simulation study investigating power estimates in phenome-wide association studies. Bmc Bioinformatics. 19: 120. PMID 29618318 DOI: 10.1186/S12859-018-2135-0  0.819
2018 Verma A, Lucas A, Verma SS, Zhang Y, Josyula N, Khan A, Hartzel DN, Lavage DR, Leader J, Ritchie MD, Pendergrass SA. PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger. American Journal of Human Genetics. PMID 29606303 DOI: 10.1016/J.Ajhg.2018.02.017  0.839
2018 Verma SS, Josyula N, Verma A, Zhang X, Veturi Y, Dewey FE, Hartzel DN, Lavage DR, Leader J, Ritchie MD, Pendergrass SA. Rare variants in drug target genes contributing to complex diseases, phenome-wide. Scientific Reports. 8: 4624. PMID 29545597 DOI: 10.1038/S41598-018-22834-4  0.837
2018 Basile AO, Ritchie MD. Informatics and machine learning to define the phenotype. Expert Review of Molecular Diagnostics. 18: 219-226. PMID 29431517 DOI: 10.1080/14737159.2018.1439380  0.688
2018 Verma SS, Ritchie MD. Another Round of "Clue" to Uncover the Mystery of Complex Traits. Genes. 9. PMID 29370075 DOI: 10.3390/Genes9020061  0.698
2018 Li B, Verma SS, Veturi YC, Verma A, Bradford Y, Haas DW, Ritchie MD. Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 23: 448-459. PMID 29218904  0.824
2018 Veturi Y, Ritchie MD. How powerful are summary-based methods for identifying expression-trait associations under different genetic architectures? Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 23: 228-239. PMID 29218884  0.352
2018 Basile AO, Byrska-Bishop M, Wallace J, Frase AT, Ritchie MD. Novel features and enhancements in BioBin, a tool for the biologically inspired binning and association analysis of rare variants. Bioinformatics (Oxford, England). 34: 527-529. PMID 28968757 DOI: 10.1093/Bioinformatics/Btx559  0.811
2017 Verma A, Ritchie MD. Current Scope and Challenges in Phenome-Wide Association Studies. Current Epidemiology Reports. 4: 321-329. PMID 29545989 DOI: 10.1007/S40471-017-0127-7  0.673
2017 Nielsen JB, Fritsche LG, Zhou W, Teslovich TM, Holmen OL, Gustafsson S, Gabrielsen ME, Schmidt EM, Beaumont R, Wolford BN, Lin M, Brummett CM, Preuss MH, Refsgaard L, Bottinger EP, ... ... Ritchie MD, et al. Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. American Journal of Human Genetics. PMID 29290336 DOI: 10.1016/J.Ajhg.2017.12.003  0.419
2017 Buchanan AH, Manickam K, Meyer MN, Wagner JK, Hallquist MLG, Williams JL, Rahm AK, Williams MS, Chen ZE, Shah CK, Garg TK, Lazzeri AL, Schwartz MLB, Lindbuchler DM, Fan AL, ... ... Ritchie MD, et al. Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 29261187 DOI: 10.1038/Gim.2017.145  0.351
2017 Helle EIT, Biegley P, Knowles JW, Leader JB, Pendergrass S, Yang W, Reaven GR, Shaw GM, Ritchie M, Priest JR. First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring. The Journal of Pediatrics. PMID 29254757 DOI: 10.1016/J.Jpeds.2017.10.046  0.696
2017 Klein TE, Ritchie MD. PharmCAT: A Pharmacogenomics Clinical Annotation Tool. Clinical Pharmacology and Therapeutics. PMID 29194583 DOI: 10.1002/Cpt.928  0.403
2017 Hall MA, Wallace J, Lucas A, Kim D, Basile AO, Verma SS, McCarty CA, Brilliant MH, Peissig PL, Kitchner TE, Verma A, Pendergrass SA, Dudek SM, Moore JH, Ritchie MD. PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies. Nature Communications. 8: 1167. PMID 29079728 DOI: 10.1038/S41467-017-00802-2  0.831
2017 McAllister K, Mechanic LE, Amos C, Aschard H, Blair IA, Chatterjee N, Conti D, Gauderman WJ, Hsu L, Hutter CM, Jankowska MM, Kerr J, Kraft P, Montgomery SB, Mukherjee B, ... ... Ritchie MD, et al. Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. American Journal of Epidemiology. 186: 753-761. PMID 28978193 DOI: 10.1093/Aje/Kwx227  0.409
2017 Ritchie MD, Davis JR, Aschard H, Battle A, Conti D, Du M, Eskin E, Fallin MD, Hsu L, Kraft P, Moore JH, Pierce BL, Bien SA, Thomas DC, Wei P, et al. Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions. American Journal of Epidemiology. 186: 771-777. PMID 28978191 DOI: 10.1093/Aje/Kwx229  0.647
2017 Mechanic LE, Lindström S, Daily KM, Sieberts SK, Amos CI, Chen HS, Cox NJ, Dathe M, Feuer EJ, Guertin MJ, Hoffman J, Liu Y, Moore JH, Myers CL, Ritchie MD, et al. Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology. Plos Genetics. 13: e1006945. PMID 28957327 DOI: 10.1371/Journal.Pgen.1006945  0.563
2017 Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, ... ... Ritchie MD, et al. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. Biodata Mining. 10: 25. PMID 28770004 DOI: 10.1186/S13040-017-0145-5  0.789
2017 Li R, Kim D, Ritchie MD. Methods to analyze big data in pharmacogenomics research. Pharmacogenomics. PMID 28612644 DOI: 10.2217/Pgs-2016-0152  0.812
2017 Kim D, Basile AO, Bang L, Horgusluoglu E, Lee S, Ritchie MD, Saykin AJ, Nho K. Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer's disease. Bmc Medical Informatics and Decision Making. 17: 61. PMID 28539126 DOI: 10.1186/S12911-017-0454-0  0.831
2017 Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse S, Dansky HM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Habegger L, et al. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. The New England Journal of Medicine. PMID 28538136 DOI: 10.1056/Nejmoa1612790  0.347
2017 Rasmussen-Torvik LJ, Almoguera B, Doheny KF, Freimuth RR, Gordon AS, Hakonarson H, Hawkins JB, Husami A, Ivacic L, Kullo IJ, Linderman MD, Manolio TA, Obeng AO, Pellegrino R, Prows CA, ... Ritchie MD, et al. Concordance between Research Sequencing and Clinical Pharmacogenetic Genotyping in the eMERGE-PGx Study. The Journal of Molecular Diagnostics : Jmd. PMID 28502727 DOI: 10.1016/J.Jmoldx.2017.04.002  0.324
2017 Haggerty CM, James CA, Calkins H, Tichnell C, Leader JB, Hartzel DN, Nevius CD, Pendergrass SA, Person TN, Schwartz M, Ritchie MD, Carey DJ, Ledbetter DH, Williams MS, Dewey FE, et al. Electronic health record phenotype in subjects with genetic variants associated with arrhythmogenic right ventricular cardiomyopathy: a study of 30,716 subjects with exome sequencing. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 28471438 DOI: 10.1038/Gim.2017.40  0.758
2017 Kim D, Volk H, Girirajan S, Pendergrass S, Hall MA, Verma SS, Schmidt RJ, Hansen RL, Ghosh D, Ludena-Rodriguez Y, Kim K, Ritchie MD, Hertz-Picciotto I, Selleck SB. The joint effect of air pollution exposure and copy number variation on risk for autism. Autism Research : Official Journal of the International Society For Autism Research. PMID 28448694 DOI: 10.1002/Aur.1799  0.794
2017 Fernández-Rhodes L, Gong J, Haessler J, Franceschini N, Graff M, Nishimura KK, Wang Y, Highland HM, Yoneyama S, Bush WS, Goodloe R, Ritchie MD, Crawford D, Gross M, Fornage M, et al. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Human Genetics. PMID 28391526 DOI: 10.1007/S00439-017-1787-6  0.735
2017 Greene CS, Garmire LX, Gilbert JA, Ritchie MD, Hunter LE. Celebrating parasites. Nature Genetics. 49: 483-484. PMID 28358134 DOI: 10.1038/ng.3830  0.409
2017 Dumitrescu L, Ritchie MD, Denny JC, El Rouby NM, McDonough CW, Bradford Y, Ramirez AH, Bielinski SJ, Basford MA, Chai HS, Peissig P, Carrell D, Pathak J, Rasmussen LV, Wang X, et al. Genome-wide study of resistant hypertension identified from electronic health records. Plos One. 12: e0171745. PMID 28222112 DOI: 10.1371/Journal.Pone.0171745  0.641
2017 Heit JA, Armasu SM, McCauley BM, Kullo IJ, Sicotte H, Pathak J, Chute CG, Gottesman O, Bottinger EP, Denny JC, Roden DM, Li R, Ritchie MD, de Andrade M. Identification of unique venous thromboembolism-susceptibility variants in African-Americans. Thrombosis and Haemostasis. PMID 28203683 DOI: 10.1160/Th16-08-0652  0.442
2017 Shan Y, Tromp G, Kuivaniemi H, Smelser DT, Verma SS, Ritchie MD, Elmore JR, Carey DJ, Conley YP, Gorin MB, Weeks DE. Genetic risk models: Influence of model size on risk estimates and precision. Genetic Epidemiology. PMID 28198095 DOI: 10.1002/Gepi.22035  0.623
2017 Verma A, Bradford Y, Verma SS, Pendergrass SA, Daar ES, Venuto C, Morse GD, Ritchie MD, Haas DW. Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202. Pharmacogenetics and Genomics. PMID 28099408 DOI: 10.1097/Fpc.0000000000000263  0.787
2016 Manrai AK, Cui Y, Bushel PR, Hall M, Karakitsios S, Mattingly CJ, Ritchie M, Schmitt C, Sarigiannis DA, Thomas DC, Wishart D, Balshaw DM, Patel CJ. Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health. Annual Review of Public Health. PMID 28068484 DOI: 10.1146/Annurev-Publhealth-082516-012737  0.7
2016 Kim D, Li R, Lucas A, Verma SS, Dudek SM, Ritchie MD. Using knowledge-driven genomic interactions for multi-omics data analysis: metadimensional models for predicting clinical outcomes in ovarian carcinoma. Journal of the American Medical Informatics Association : Jamia. PMID 28040685 DOI: 10.1093/Jamia/Ocw165  0.809
2016 Abul-Husn NS, Manickam K, Jones LK, Wright EA, Hartzel DN, Gonzaga-Jauregui C, O'Dushlaine C, Leader JB, Lester Kirchner H, Lindbuchler DM, Barr ML, Giovanni MA, Ritchie MD, Overton JD, Reid JG, et al. Genetic identification of familial hypercholesterolemia within a single U.S. health care system. Science (New York, N.Y.). 354. PMID 28008010 DOI: 10.1126/Science.Aaf7000  0.368
2016 Dewey FE, Murray MF, Overton JD, Habegger L, Leader JB, Fetterolf SN, O'Dushlaine C, Van Hout CV, Staples J, Gonzaga-Jauregui C, Metpally R, Pendergrass SA, Giovanni MA, Kirchner HL, Balasubramanian S, ... ... Ritchie MD, et al. Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study. Science (New York, N.Y.). 354. PMID 28008009 DOI: 10.1126/Science.Aaf6814  0.779
2016 Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, ... ... Ritchie MD, et al. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The Lancet. Diabetes & Endocrinology. PMID 27908689 DOI: 10.1016/S2213-8587(16)30396-5  0.309
2016 Jones GT, Tromp G, Kuivaniemi H, Gretarsdottir S, Baas AF, Giusti B, Strauss E, van 't Hof FN, Webb T, Erdman R, Ritchie MD, Elmore JR, Verma A, Pendergrass S, Kullo IJ, et al. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci. Circulation Research. PMID 27899403 DOI: 10.1161/Circresaha.116.308765  0.803
2016 Verma SS, Lucas AM, Lavage DR, Leader JB, Metpally R, Krishnamurthy S, Dewey F, Borecki I, Lopez A, Overton J, Penn J, Reid J, Pendergrass SA, Breitwieser G, Ritchie MD. IDENTIFYING GENETIC ASSOCIATIONS WITH VARIABILITY IN METABOLIC HEALTH AND BLOOD COUNT LABORATORY VALUES: DIVING INTO THE QUANTITATIVE TRAITS BY LEVERAGING LONGITUDINAL DATA FROM AN EHR. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 533-544. PMID 27897004  0.825
2016 Yoneyama S, Yao J, Guo X, Fernandez-Rhodes L, Lim U, Boston J, Buzková P, Carlson CS, Cheng I, Cochran B, Cooper R, Ehret G, Fornage M, Gong J, Gross M, ... ... Ritchie MD, et al. Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations. International Journal of Obesity (2005). PMID 27867202 DOI: 10.1038/Ijo.2016.207  0.396
2016 De R, Verma SS, Holzinger E, Hall M, Burt A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Lange LA, Lanktree MB, Larson EB, North KE, Reiner AP, ... ... Ritchie MD, et al. Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts. Human Genetics. PMID 27848076 DOI: 10.1007/S00439-016-1738-7  0.817
2016 Verma SS, Cooke Bailey JN, Lucas A, Bradford Y, Linneman JG, Hauser MA, Pasquale LR, Peissig PL, Brilliant MH, McCarty CA, Haines JL, Wiggs JL, Vrabec TR, Tromp G, Ritchie MD, et al. Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium. Plos Genetics. 12: e1006186. PMID 27623284 DOI: 10.1371/Journal.Pgen.1006186  0.768
2016 Moore CC, Basile AO, Wallace JR, Frase AT, Ritchie MD. A biologically informed method for detecting rare variant associations. Biodata Mining. 9: 27. PMID 27582876 DOI: 10.1186/S13040-016-0107-3  0.723
2016 Verma A, Verma SS, Pendergrass SA, Crawford DC, Crosslin DR, Kuivaniemi H, Bush WS, Bradford Y, Kullo I, Bielinski SJ, Li R, Denny JC, Peissig P, Hebbring S, De Andrade M, ... Ritchie MD, et al. eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants. Bmc Medical Genomics. 9: 32. PMID 27535653 DOI: 10.1186/S12920-016-0191-8  0.827
2016 Verma A, Basile AO, Bradford Y, Kuivaniemi H, Tromp G, Carey D, Gerhard GS, Crowe JE, Ritchie MD, Pendergrass SA. Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. Plos One. 11: e0160573. PMID 27508393 DOI: 10.1371/Journal.Pone.0160573  0.836
2016 van 't Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, de Andrade M, Baas AF, Blankensteijn JD, Böttinger EP, Bown MJ, Broderick J, Bijlenga P, Carrell DS, Crawford DC, Crosslin DR, ... ... Ritchie MD, et al. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. Journal of the American Heart Association. 5. PMID 27418160 DOI: 10.1161/Jaha.115.002603  0.58
2016 Hall MA, Moore JH, Ritchie MD. Embracing Complex Associations in Common Traits: Critical Considerations for Precision Medicine. Trends in Genetics : Tig. PMID 27392675 DOI: 10.1016/J.Tig.2016.06.001  0.828
2016 Oetjens MT, Bush WS, Denny JC, Birdwell K, Kodaman N, Verma A, Dilks HH, Pendergrass SA, Ritchie MD, Crawford DC. Evidence for extensive pleiotropy among pharmacogenes. Pharmacogenomics. 0. PMID 27249515 DOI: 10.2217/Pgs-2015-0007  0.784
2016 Li R, Dudek SM, Kim D, Hall MA, Bradford Y, Peissig PL, Brilliant MH, Linneman JG, McCarty CA, Bao L, Ritchie MD. Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network. Biodata Mining. 9: 18. PMID 27168765 DOI: 10.1186/S13040-016-0094-4  0.842
2016 Butkiewicz M, Cooke Bailey JN, Frase A, Dudek S, Yaspan BL, Ritchie MD, Pendergrass SA, Haines JL. Pathway analysis by randomization incorporating structure-PARIS: an update. Bioinformatics (Oxford, England). PMID 27153576 DOI: 10.1093/Bioinformatics/Btw130  0.778
2016 Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, et al. The phenotypic legacy of admixture between modern humans and Neandertals. Science (New York, N.Y.). 351: 737-41. PMID 26912863 DOI: 10.1126/Science.Aad2149  0.8
2016 Bush WS, Crosslin DR, Obeng AO, Wallace J, Almoguera B, Basford MA, Bielinski SJ, Carrell DS, Connolly JJ, Crawford D, Doheny KF, Gallego CJ, Gordon AS, Keating B, Kirby J, ... ... Ritchie MD, et al. Genetic Variation among 82 Pharmacogenes: the PGRN-Seq data from the eMERGE Network. Clinical Pharmacology and Therapeutics. PMID 26857349 DOI: 10.1002/Cpt.350  0.779
2016 Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, et al. Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiology of Aging. 38: 141-50. PMID 26827652 DOI: 10.1016/J.Neurobiolaging.2015.10.031  0.779
2016 Kim D, Lucas A, Glessner J, Verma SS, Bradford Y, Li R, Frase AT, Hakonarson H, Peissig P, Brilliant M, Ritchie MD. BIOFILTER AS A FUNCTIONAL ANNOTATION PIPELINE FOR COMMON AND RARE COPY NUMBER BURDEN. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 21: 357-68. PMID 26776200  0.842
2016 Basile AO, Wallace JR, Peissig P, McCarty CA, Brilliant M, Ritchie MD. KNOWLEDGE DRIVEN BINNING AND PHEWAS ANALYSIS IN MARSHFIELD PERSONALIZED MEDICINE RESEARCH PROJECT USING BIOBIN. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 21: 249-60. PMID 26776191  0.721
2016 Verma A, Leader JB, Verma SS, Frase A, Wallace J, Dudek S, Lavage DR, VAN Hout CV, Dewey FE, Penn J, Lopez A, Overton JD, Carey DJ, Ledbetter DH, Kirchner HL, ... Ritchie MD, et al. INTEGRATING CLINICAL LABORATORY MEASURES AND ICD-9 CODE DIAGNOSES IN PHENOME-WIDE ASSOCIATION STUDIES. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 21: 168-79. PMID 26776183  0.839
2016 Verma SS, Frase AT, Verma A, Pendergrass SA, Mahony S, Haas DW, Ritchie MD. PHENOME-WIDE INTERACTION STUDY (PheWIS) IN AIDS CLINICAL TRIALS GROUP DATA (ACTG). Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 21: 57-68. PMID 26776173  0.849
2016 Bailey JN, Loomis SJ, Kang JH, Allingham RR, Gharahkhani P, Khor CC, Burdon KP, Aschard H, Chasman DI, Igo RP, Hysi PG, Glastonbury CA, Ashley-Koch A, Brilliant M, Brown AA, ... ... Ritchie M, et al. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nature Genetics. PMID 26752265 DOI: 10.1038/Ng.3482  0.715
2016 Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, ... ... Ritchie MD, et al. Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records. Jama. 315: 47-57. PMID 26746457 DOI: 10.1001/Jama.2015.17701  0.733
2015 Leader JB, Pendergrass SA, Verma A, Carey DJ, Hartzel DN, Ritchie MD, Kirchner HL. Contrasting Association Results between Existing PheWAS Phenotype Definition Methods and Five Validated Electronic Phenotypes. Amia ... Annual Symposium Proceedings / Amia Symposium. Amia Symposium. 2015: 824-32. PMID 26958218  0.809
2015 De R, Verma SS, Drenos F, Holzinger ER, Holmes MV, Hall MA, Crosslin DR, Carrell DS, Hakonarson H, Jarvik G, Larson E, Pacheco JA, Rasmussen-Torvik LJ, Moore CB, Asselbergs FW, ... ... Ritchie MD, et al. Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR). Biodata Mining. 8: 41. PMID 26674805 DOI: 10.1186/S13040-015-0074-0  0.791
2015 Keating BJ, Setten Jv, Jacobson PA, Holmes MV, Verma SS, Chandrupatla HR, Nair N, Gao H, Li YR, Chang B, Wong C, Phillips R, Cole BS, Mukhtar E, Zhang W, ... ... Ritchie MD, et al. Design and Implementation of the International Genetics and Translational Research in Transplantation Network Transplantation. 99: 2401-2412. PMID 26479416 DOI: 10.1097/Tp.0000000000000913  0.718
2015 Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, ... ... Ritchie MD, et al. Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies. Genome Medicine. 7: 90. PMID 26423053 DOI: 10.1186/S13073-015-0211-X  0.675
2015 Namjou B, Marsolo K, Lingren T, Ritchie MD, Verma SS, Cobb BL, Perry C, Kitchner TE, Brilliant MH, Peissig PL, Borthwick KM, Williams MS, Grafton J, Jarvik GP, Holm IA, et al. A GWAS Study on Liver Function Test Using eMERGE Network Participants. Plos One. 10: e0138677. PMID 26413716 DOI: 10.1371/Journal.Pone.0138677  0.681
2015 Gallego CJ, Burt A, Sundaresan AS, Ye Z, Shaw C, Crosslin DR, Crane PK, Fullerton SM, Hansen K, Carrell D, Kuivaniemi H, Derr K, de Andrade M, McCarty CA, Kitchner TE, ... ... Ritchie M, et al. Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network. American Journal of Human Genetics. PMID 26365338 DOI: 10.1016/J.Ajhg.2015.08.008  0.335
2015 Crosslin DR, Robertson PD, Carrell DS, Gordon AS, Hanna DS, Burt A, Fullerton SM, Scrol A, Ralston J, Leppig K, Hartzler A, Baldwin E, Andrade Md, Kullo IJ, Tromp G, ... ... Ritchie MD, et al. Prospective participant selection and ranking to maximize actionable pharmacogenetic variants and discovery in the eMERGE Network. Genome Medicine. 7: 67. PMID 26221186 DOI: 10.1186/S13073-015-0181-Z  0.381
2015 Crawford DC, Goodloe R, Farber-Eger E, Boston J, Pendergrass SA, Haines JL, Ritchie MD, Bush WS. Leveraging Epidemiologic and Clinical Collections for Genomic Studies of Complex Traits. Human Heredity. 79: 137-46. PMID 26201699 DOI: 10.1159/000381805  0.807
2015 Pendergrass SA, Verma A, Okula A, Hall MA, Crawford DC, Ritchie MD. Phenome-Wide Association Studies: Embracing Complexity for Discovery. Human Heredity. 79: 111-23. PMID 26201697 DOI: 10.1159/000381851  0.838
2015 Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, ... ... Ritchie MD, et al. A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. The Pharmacogenomics Journal. PMID 26169577 DOI: 10.1038/Tpj.2015.51  0.677
2015 Pendergrass SA, Ritchie MD. Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery. Current Genetic Medicine Reports. 3: 92-100. PMID 26146598 DOI: 10.1007/S40142-015-0067-9  0.803
2015 Kim D, Li R, Dudek SM, Ritchie MD. Predicting censored survival data based on the interactions between meta-dimensional omics data in breast cancer. Journal of Biomedical Informatics. PMID 26048077 DOI: 10.1016/J.Jbi.2015.05.019  0.808
2015 Hall MA, Verma SS, Wallace J, Lucas A, Berg RL, Connolly J, Crawford DC, Crosslin DR, de Andrade M, Doheny KF, Haines JL, Harley JB, Jarvik GP, Kitchner T, Kuivaniemi H, ... ... Ritchie MD, et al. Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network. Genetic Epidemiology. 39: 376-84. PMID 25982363 DOI: 10.1002/Gepi.21902  0.829
2015 Moore CB, Verma A, Pendergrass S, Verma SS, Johnson DH, Daar ES, Gulick RM, Haubrich R, Robbins GK, Ritchie MD, Haas DW. Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols. Open Forum Infectious Diseases. 2: ofu113. PMID 25884002 DOI: 10.1093/Ofid/Ofu113  0.819
2015 Ritchie MD, de Andrade M, Kuivaniemi H. The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research. Frontiers in Genetics. 6: 104. PMID 25852745 DOI: 10.3389/Fgene.2015.00104  0.383
2015 Pendergrass SA, Verma SS, Hall MA, Holzinger ER, Moore CB, Wallace JR, Dudek SM, Huggins W, Kitchner T, Waudby C, Berg R, Mccarty CA, Ritchie MD. Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using biofilter, and gene-environment interactions using the Phenx Toolkit*. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 495-505. PMID 25741542  0.832
2015 Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, ... ... Ritchie MD, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 518: 197-206. PMID 25673413 DOI: 10.1038/Nature14177  0.322
2015 Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, ... ... Ritchie MD, et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature. 518: 187-96. PMID 25673412 DOI: 10.1038/Nature14132  0.372
2015 Kim D, Li R, Dudek SM, Wallace JR, Ritchie MD. Binning somatic mutations based on biological knowledge for predicting survival: an application in renal cell carcinoma. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 96-107. PMID 25592572  0.79
2015 Ritchie MD, Holzinger ER, Li R, Pendergrass SA, Kim D. Methods of integrating data to uncover genotype-phenotype interactions. Nature Reviews. Genetics. 16: 85-97. PMID 25582081 DOI: 10.1038/nrg3868  0.831
2015 Ritchie MD. Finding the epistasis needles in the genome-wide haystack. Methods in Molecular Biology (Clifton, N.J.). 1253: 19-33. PMID 25403525 DOI: 10.1007/978-1-4939-2155-3_2  0.521
2015 Chen HS, Hutter CM, Mechanic LE, Amos CI, Bafna V, Hauser ER, Hernandez RD, Li C, Liberles DA, McAllister K, Moore JH, Paltoo DN, Papanicolaou GJ, Peng B, Ritchie MD, et al. Genetic simulation tools for post-genome wide association studies of complex diseases. Genetic Epidemiology. 39: 11-9. PMID 25371374 DOI: 10.1002/Gepi.21870  0.65
2015 Crosslin DR, Carrell DS, Burt A, Kim DS, Underwood JG, Hanna DS, Comstock BA, Baldwin E, de Andrade M, Kullo IJ, Tromp G, Kuivaniemi H, Borthwick KM, McCarty CA, Peissig PL, ... ... Ritchie MD, et al. Genetic variation in the HLA region is associated with susceptibility to herpes zoster. Genes and Immunity. 16: 1-7. PMID 25297839 DOI: 10.1038/Gene.2014.51  0.694
2015 Kim D, Joung JG, Sohn KA, Shin H, Park YR, Ritchie MD, Kim JH. Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction. Journal of the American Medical Informatics Association : Jamia. 22: 109-20. PMID 25002459 DOI: 10.1136/Amiajnl-2013-002481  0.727
2015 Pendergrass SA, Verma A, Okula A, Hall MA, Crawford DC, Ritchie MD, Génin E, Devoto M, Li H, Jeng J, Wu Q, Ziegler A, Mwambi H, König IR, Pineda S, et al. Contents Vol. 79, 2015 Human Heredity. 79. DOI: 10.1159/000382044  0.749
2015 Freitag D, Butterworth AS, Willeit P, Howson JMM, Burgess S, Kaptoge S, Young R, Ho WK, Wood AM, Sweeting M, Spackman S, Staley JR, Ramond A, Harshfield E, Nielsen SF, ... ... Ritchie MD, et al. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A Mendelian randomisation analysis The Lancet Diabetes and Endocrinology. 3: 243-253. DOI: 10.1016/S2213-8587(15)00034-0  0.623
2014 Jeff JM, Brown-Gentry K, Goodloe R, Ritchie MD, Denny JC, Kho AN, Armstrong LL, McClellan B, Mayo P, Allen M, Jin H, Gillani NB, Schnetz-Boutaud N, Dilks HH, Basford MA, et al. Replication of SCN5A Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies. Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. Evobio (Conference), Author. 2014: 939-951. PMID 25590050 DOI: 10.1007/978-3-662-45523-4_76  0.33
2014 Verma SS, de Andrade M, Tromp G, Kuivaniemi H, Pugh E, Namjou-Khales B, Mukherjee S, Jarvik GP, Kottyan LC, Burt A, Bradford Y, Armstrong GD, Derr K, Crawford DC, Haines JL, ... ... Ritchie MD, et al. Imputation and quality control steps for combining multiple genome-wide datasets. Frontiers in Genetics. 5: 370. PMID 25566314 DOI: 10.3389/Fgene.2014.00370  0.735
2014 Chhibber A, Kroetz DL, Tantisira KG, McGeachie M, Cheng C, Plenge R, Stahl E, Sadee W, Ritchie MD, Pendergrass SA. Genomic architecture of pharmacological efficacy and adverse events. Pharmacogenomics. 15: 2025-48. PMID 25521360 DOI: 10.2217/Pgs.14.144  0.779
2014 Namjou B, Marsolo K, Caroll RJ, Denny JC, Ritchie MD, Verma SS, Lingren T, Porollo A, Cobb BL, Perry C, Kottyan LC, Rothenberg ME, Thompson SD, Holm IA, Kohane IS, et al. Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. Frontiers in Genetics. 5: 401. PMID 25477900 DOI: 10.3389/Fgene.2014.00401  0.676
2014 Hall MA, Verma A, Brown-Gentry KD, Goodloe R, Boston J, Wilson S, McClellan B, Sutcliffe C, Dilks HH, Gillani NB, Jin H, Mayo P, Allen M, Schnetz-Boutaud N, Crawford DC, ... Ritchie MD, et al. Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study. Plos Genetics. 10: e1004678. PMID 25474351 DOI: 10.1371/Journal.Pgen.1004678  0.831
2014 Malinowski JR, Denny JC, Bielinski SJ, Basford MA, Bradford Y, Peissig PL, Carrell D, Crosslin DR, Pathak J, Rasmussen L, Pacheco J, Kho A, Newton KM, Li R, Kullo IJ, ... ... Ritchie MD, et al. Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. Plos One. 9: e111301. PMID 25436638 DOI: 10.1371/Journal.Pone.0111301  0.419
2014 Crosslin DR, Tromp G, Burt A, Kim DS, Verma SS, Lucas AM, Bradford Y, Crawford DC, Armasu SM, Heit JA, Hayes MG, Kuivaniemi H, Ritchie MD, Jarvik GP, de Andrade M, et al. Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records. Frontiers in Genetics. 5: 352. PMID 25414722 DOI: 10.3389/Fgene.2014.00352  0.672
2014 Ritchie MD, Verma SS, Hall MA, Goodloe RJ, Berg RL, Carrell DS, Carlson CS, Chen L, Crosslin DR, Denny JC, Jarvik G, Li R, Linneman JG, Pathak J, Peissig P, et al. Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci. Molecular Vision. 20: 1281-95. PMID 25352737  0.822
2014 Barrie ES, Weinshenker D, Verma A, Pendergrass SA, Lange LA, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, et al. Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity. Circulation Research. 115: 1017-25. PMID 25326128 DOI: 10.1161/Circresaha.116.304398  0.775
2014 Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, ... ... Ritchie M, et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics. 46: 1173-86. PMID 25282103 DOI: 10.1038/Ng.3097  0.457
2014 Kim D, Li R, Dudek SM, Frase AT, Pendergrass SA, Ritchie MD. Knowledge-driven genomic interactions: an application in ovarian cancer. Biodata Mining. 7: 20. PMID 25214892 DOI: 10.1186/1756-0381-7-20  0.798
2014 Restrepo NA, Spencer KL, Goodloe R, Garrett TA, Heiss G, Bůžková P, Jorgensen N, Jensen RA, Matise TC, Hindorff LA, Klein BE, Klein R, Wong TY, Cheng CY, Cornes BK, ... ... Ritchie MD, et al. Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study. Investigative Ophthalmology & Visual Science. 55: 6839-50. PMID 25205864 DOI: 10.1167/Iovs.14-14246  0.502
2014 Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, et al. Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Frontiers in Genetics. 5: 250. PMID 25177340 DOI: 10.3389/Fgene.2014.00250  0.809
2014 Ciesielski TH, Pendergrass SA, White MJ, Kodaman N, Sobota RS, Huang M, Bartlett J, Li J, Pan Q, Gui J, Selleck SB, Amos CI, Ritchie MD, Moore JH, Williams SM. Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors. Biodata Mining. 7: 10. PMID 25071867 DOI: 10.1186/1756-0381-7-10  0.828
2014 Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD. eMERGEing progress in genomics-the first seven years. Frontiers in Genetics. 5: 184. PMID 24987407 DOI: 10.3389/Fgene.2014.00184  0.756
2014 Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD, Feitosa MF, Tekola-Ayele F, Chu AY, Nolte IM, Dastani Z, ... ... Ritchie MD, et al. Pleiotropic genes for metabolic syndrome and inflammation. Molecular Genetics and Metabolism. 112: 317-38. PMID 24981077 DOI: 10.1016/J.Ymgme.2014.04.007  0.777
2014 Rasmussen-Torvik LJ, Stallings SC, Gordon AS, Almoguera B, Basford MA, Bielinski SJ, Brautbar A, Brilliant MH, Carrell DS, Connolly JJ, Crosslin DR, Doheny KF, Gallego CJ, Gottesman O, Kim DS, ... ... Ritchie MD, et al. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clinical Pharmacology and Therapeutics. 96: 482-9. PMID 24960519 DOI: 10.1038/Clpt.2014.137  0.53
2014 Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, ... ... Ritchie MD, et al. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature Genetics. 46: 826-36. PMID 24952745 DOI: 10.1038/Ng.3014  0.792
2014 Sun X, Lu Q, Mukherjee S, Mukheerjee S, Crane PK, Elston R, Ritchie MD. Analysis pipeline for the epistasis search - statistical versus biological filtering. Frontiers in Genetics. 5: 106. PMID 24817878 DOI: 10.3389/Fgene.2014.00106  0.399
2014 Jeff JM, Armstrong LL, Ritchie MD, Denny JC, Kho AN, Basford MA, Wolf WA, Pacheco JA, Li R, Chisholm RL, Roden DM, Hayes MG, Crawford DC. Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans. Plos One. 9: e86931. PMID 24595071 DOI: 10.1371/Journal.Pone.0086931  0.384
2014 Kim D, Shin H, Sohn KA, Verma A, Ritchie MD, Kim JH. Incorporating inter-relationships between different levels of genomic data into cancer clinical outcome prediction. Methods (San Diego, Calif.). 67: 344-53. PMID 24561168 DOI: 10.1016/J.Ymeth.2014.02.003  0.786
2014 Chhibber A, Mefford J, Stahl EA, Pendergrass SA, Baldwin RM, Owzar K, Li M, Winer EP, Hudis CA, Zembutsu H, Kubo M, Nakamura Y, McLeod HL, Ratain MJ, Shulman LN, ... Ritchie MD, et al. Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance). The Pharmacogenomics Journal. 14: 336-42. PMID 24513692 DOI: 10.1038/Tpj.2014.2  0.71
2014 Hall MA, Dudek SM, Goodloe R, Crawford DC, Pendergrass SA, Peissig P, Brilliant M, McCarty CA, Ritchie MD. Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield Personalized Medicine Research Project Biobank. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 200-11. PMID 24297547  0.821
2014 Holzinger ER, Dudek SM, Frase AT, Pendergrass SA, Ritchie MD. ATHENA: the analysis tool for heritable and environmental network associations. Bioinformatics (Oxford, England). 30: 698-705. PMID 24149050 DOI: 10.1093/Bioinformatics/Btt572  0.841
2014 Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, et al. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Human Genetics. 133: 95-109. PMID 24026423 DOI: 10.1007/S00439-013-1355-7  0.488
2014 Kim D, Ritchie MD. Data Integration for Cancer Clinical Outcome Prediction Journal of Health and Medical Informatics. 5: 1-2. DOI: 10.4172/2157-7420.1000E122  0.666
2013 Kim D, Kim S, Risacher SL, Shen L, Ritchie MD, Weiner MW, Saykin AJ, Nho K. A Graph-Based Integration of Multimodal Brain Imaging Data for the Detection of Early Mild Cognitive Impairment (E-MCI). Multimodal Brain Image Analysis : Third International Workshop, Mbia 2013, Held in Conjunction With Miccai 2013, Nagoya, Japan, September 22, 2013 : Proceedings / Li Shen, Tianming Liu, Pew-Thian Yap, Heng Huang, Dinggang Shen, Carl-Fre.... 8159: 159-169. PMID 25383392 DOI: 10.1007/978-3-319-02126-3_16  0.639
2013 Moore CB, Wallace JR, Wolfe DJ, Frase AT, Pendergrass SA, Weiss KM, Ritchie MD. Low frequency variants, collapsed based on biological knowledge, uncover complexity of population stratification in 1000 genomes project data. Plos Genetics. 9: e1003959. PMID 24385916 DOI: 10.1371/Journal.Pgen.1003959  0.808
2013 Pendergrass SA, Frase A, Wallace J, Wolfe D, Katiyar N, Moore C, Ritchie MD. Genomic analyses with biofilter 2.0: knowledge driven filtering, annotation, and model development. Biodata Mining. 6: 25. PMID 24378202 DOI: 10.1186/1756-0381-6-25  0.827
2013 Kim D, Li R, Dudek SM, Ritchie MD. ATHENA: Identifying interactions between different levels of genomic data associated with cancer clinical outcomes using grammatical evolution neural network. Biodata Mining. 6: 23. PMID 24359638 DOI: 10.1186/1756-0381-6-23  0.819
2013 Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, ... ... Ritchie MD, et al. Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data. Plos One. 8: e81503. PMID 24349080 DOI: 10.1371/Journal.Pone.0081503  0.458
2013 Denny JC, Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM, Ramirez AH, Bowton E, Basford MA, Carrell DS, Peissig PL, Kho AN, Pacheco JA, et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nature Biotechnology. 31: 1102-10. PMID 24270849 DOI: 10.1038/Nbt.2749  0.827
2013 Behr ER, Ritchie MD, Tanaka T, Kääb S, Crawford DC, Nicoletti P, Floratos A, Sinner MF, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Zumhagen S, Guicheney P, Bishopric NH, et al. Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. Plos One. 8: e78511. PMID 24223155 DOI: 10.1371/Journal.Pone.0078511  0.445
2013 Wolfe D, Dudek S, Ritchie MD, Pendergrass SA. Visualizing genomic information across chromosomes with PhenoGram. Biodata Mining. 6: 18. PMID 24131735 DOI: 10.1186/1756-0381-6-18  0.74
2013 Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S, Bůžková P, Fornage M, Gross M, Pankratz N, Pankow JS, Schreiner PJ, Cooper R, ... ... Ritchie MD, et al. Fine Mapping and Identification of BMI Loci in African Americans. American Journal of Human Genetics. 93: 661-71. PMID 24094743 DOI: 10.1016/J.Ajhg.2013.08.012  0.434
2013 Carlson CS, Matise TC, North KE, Haiman CA, Fesinmeyer MD, Buyske S, Schumacher FR, Peters U, Franceschini N, Ritchie MD, Duggan DJ, Spencer KL, Dumitrescu L, Eaton CB, Thomas F, et al. Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. Plos Biology. 11: e1001661. PMID 24068893 DOI: 10.1371/Journal.Pbio.1001661  0.688
2013 Hulgan T, Stein JH, Cotter BR, Murdock DG, Ritchie MD, Dube MP, Gerschenson M, Haas DW, Torriani FJ. Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. Aids Research and Human Retroviruses. 29: 1293-9. PMID 23944767 DOI: 10.1089/Aid.2013.0079  0.31
2013 Moore JH, Ritchie MD. The central role of biological data mining in connecting diverse disciplines. Biodata Mining. 6: 14. PMID 23937773 DOI: 10.1186/1756-0381-6-14  0.537
2013 Pare G, Kubo M, Byrd JB, McCarty CA, Woodard-Grice A, Teo KK, Anand SS, Zuvich RL, Bradford Y, Ross S, Nakamura Y, Ritchie M, Brown NJ. Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenetics and Genomics. 23: 470-8. PMID 23838604 DOI: 10.1097/Fpc.0B013E328363C137  0.775
2013 Park SL, Cheng I, Pendergrass SA, Kucharska-Newton AM, Lim U, Ambite JL, Caberto CP, Monroe KR, Schumacher F, Hindorff LA, Oetjens MT, Wilson S, Goodloe RJ, Love SA, Henderson BE, ... ... Ritchie MD, et al. Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. American Journal of Epidemiology. 178: 780-90. PMID 23820787 DOI: 10.1093/Aje/Kwt028  0.744
2013 Moore CB, Wallace JR, Frase AT, Pendergrass SA, Ritchie MD. BioBin: a bioinformatics tool for automating the binning of rare variants using publicly available biological knowledge. Bmc Medical Genomics. 6: S6. PMID 23819467 DOI: 10.1186/1755-8794-6-S2-S6  0.825
2013 McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA, Rottscheit C, Peissig P, Stefanski E, McCarty CA, Zuvich RL, ... Ritchie MD, et al. Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records. Plos One. 8: e63481. PMID 23762230 DOI: 10.1371/Journal.Pone.0063481  0.795
2013 Gottesman O, Kuivaniemi H, Tromp G, Faucett WA, Li R, Manolio TA, Sanderson SC, Kannry J, Zinberg R, Basford MA, Brilliant M, Carey DJ, Chisholm RL, Chute CG, Connolly JJ, ... ... Ritchie MD, et al. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 15: 761-71. PMID 23743551 DOI: 10.1038/Gim.2013.72  0.542
2013 Fesinmeyer MD, North KE, Ritchie MD, Lim U, Franceschini N, Wilkens LR, Gross MD, Bůžková P, Glenn K, Quibrera PM, Fernández-Rhodes L, Li Q, Fowke JH, Li R, Carlson CS, et al. Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring, Md.). 21: 835-46. PMID 23712987 DOI: 10.1002/Oby.20268  0.368
2013 Ding K, de Andrade M, Manolio TA, Crawford DC, Rasmussen-Torvik LJ, Ritchie MD, Denny JC, Masys DR, Jouni H, Pachecho JA, Kho AN, Roden DM, Chisholm R, Kullo IJ. Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study. G3 (Bethesda, Md.). 3: 1061-8. PMID 23696099 DOI: 10.1534/G3.113.006452  0.476
2013 Oetjens MT, Denny JC, Ritchie MD, Gillani NB, Richardson DM, Restrepo NA, Pulley JM, Dilks HH, Basford MA, Bowton E, Masys DR, Wilke RA, Roden DM, Crawford DC. Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Pharmacogenomics. 14: 735-44. PMID 23651022 DOI: 10.2217/Pgs.13.64  0.335
2013 Zhang L, Buzkova P, Wassel CL, Roman MJ, North KE, Crawford DC, Boston J, Brown-Gentry KD, Cole SA, Deelman E, Goodloe R, Wilson S, Heiss G, Jenny NS, Jorgensen NW, ... ... Ritchie MD, et al. Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study. Atherosclerosis. 228: 390-9. PMID 23587283 DOI: 10.1016/J.Atherosclerosis.2013.02.038  0.426
2013 Girirajan S, Johnson RL, Tassone F, Balciuniene J, Katiyar N, Fox K, Baker C, Srikanth A, Yeoh KH, Khoo SJ, Nauth TB, Hansen R, Ritchie M, Hertz-Picciotto I, Eichler EE, et al. Global increases in both common and rare copy number load associated with autism. Human Molecular Genetics. 22: 2870-80. PMID 23535821 DOI: 10.1093/Hmg/Ddt136  0.383
2013 Jeff JM, Ritchie MD, Denny JC, Kho AN, Ramirez AH, Crosslin D, Armstrong L, Basford MA, Wolf WA, Pacheco JA, Chisholm RL, Roden DM, Hayes MG, Crawford DC. Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Annals of Human Genetics. 77: 321-32. PMID 23534349 DOI: 10.1111/Ahg.12023  0.436
2013 McGeachie MJ, Stahl EA, Himes BE, Pendergrass SA, Lima JJ, Irvin CG, Peters SP, Ritchie MD, Plenge RM, Tantisira KG. Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. Pharmacogenetics and Genomics. 23: 324-8. PMID 23532052 DOI: 10.1097/Fpc.0B013E3283607Acf  0.753
2013 Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout JS, Bastarache L, Ramirez AH, Mosley JD, Pulley JM, Basford MA, Bradford Y, Rasmussen LV, Pathak J, Chute CG, Kullo IJ, et al. Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation. 127: 1377-85. PMID 23463857 DOI: 10.1161/Circulationaha.112.000604  0.774
2013 Spencer KL, Malinowski J, Carty CL, Franceschini N, Fernández-Rhodes L, Young A, Cheng I, Ritchie MD, Haiman CA, Wilkens L, Chunyuanwu, Matise TC, Carlson CS, Brennan K, Park A, et al. Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. Plos One. 8: e55258. PMID 23424626 DOI: 10.1371/Journal.Pone.0055258  0.453
2013 Holzinger ER, Dudek SM, Frase AT, Krauss RM, Medina MW, Ritchie MD. ATHENA: a tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 385-96. PMID 23424143  0.83
2013 Bush WS, Boston J, Pendergrass SA, Dumitrescu L, Goodloe R, Brown-Gentry K, Wilson S, McClellan B, Torstenson E, Basford MA, Spencer KL, Ritchie MD, Crawford DC. Enabling high-throughput genotype-phenotype associations in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 373-84. PMID 23424142  0.848
2013 Moore CB, Wallace JR, Frase AT, Pendergrass SA, Ritchie MD. Using BioBin to explore rare variant population stratification. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 332-43. PMID 23424138  0.808
2013 Crawford DC, Goodloe R, Brown-Gentry K, Wilson S, Roberson J, Gillani NB, Ritchie MD, Dilks HH, Bush WS. Characterization of the Metabochip in diverse populations from the International HapMap Project in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 188-99. PMID 23424124  0.741
2013 Pendergrass SA, Verma SS, Holzinger ER, Moore CB, Wallace J, Dudek SM, Huggins W, Kitchner T, Waudby C, Berg R, McCarty CA, Ritchie MD. Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using Biofilter, and gene-environment interactions using the PhenX Toolkit. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 147-58. PMID 23424120  0.836
2013 Pendergrass SA, Brown-Gentry K, Dudek S, Frase A, Torstenson ES, Goodloe R, Ambite JL, Avery CL, Buyske S, Bůžková P, Deelman E, Fesinmeyer MD, Haiman CA, Heiss G, Hindorff LA, ... ... Ritchie MD, et al. Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. Plos Genetics. 9: e1003087. PMID 23382687 DOI: 10.1371/Journal.Pgen.1003087  0.796
2013 Peters U, North KE, Sethupathy P, Buyske S, Haessler J, Jiao S, Fesinmeyer MD, Jackson RD, Kuller LH, Rajkovic A, Lim U, Cheng I, Schumacher F, Wilkens L, Li R, ... ... Ritchie M, et al. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. Plos Genetics. 9: e1003171. PMID 23341774 DOI: 10.1371/Journal.Pgen.1003171  0.425
2013 Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, et al. Genetic variation associated with circulating monocyte count in the eMERGE Network. Human Molecular Genetics. 22: 2119-27. PMID 23314186 DOI: 10.1093/Hmg/Ddt010  0.439
2013 Fesinmeyer MD, North KE, Lim U, Bůžková P, Crawford DC, Haessler J, Gross MD, Fowke JH, Goodloe R, Love SA, Graff M, Carlson CS, Kuller LH, Matise TC, Hong CP, ... ... Ritchie MD, et al. Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. Bmc Medical Genetics. 14: 6. PMID 23311614 DOI: 10.1186/1471-2350-14-6  0.31
2013 Heit JA, de Andrade M, Armasu SM, Kullo IJ, Pathak J, Chute CG, Gottesman O, Bottinger EP, Denny JC, Roden DM, Li R, Ritchie MD. Genome-Wide Association Study (GWAS) Of Venous Thromboembolism (VTE) In African-Americans From The Electronic Medical Records & Genomics (eMERGE) Networkm Blood. 122: 458-458. DOI: 10.1182/Blood.V122.21.458.458  0.426
2012 Holzinger ER, Grady B, Ritchie MD, Ribaudo HJ, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford DB, Daar ES, McLaren P, Haas DW. Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants. Pharmacogenetics and Genomics. 22: 858-67. PMID 23080225 DOI: 10.1097/Fpc.0B013E32835A450B  0.817
2012 Holzinger ER, Hulgan T, Ellis RJ, Samuels DC, Ritchie MD, Haas DW, Kallianpur AR, Bloss CS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, et al. Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. Journal of Neurovirology. 18: 511-20. PMID 23073667 DOI: 10.1007/S13365-012-0133-Y  0.782
2012 Rasmussen-Torvik LJ, Pacheco JA, Wilke RA, Thompson WK, Ritchie MD, Kho AN, Muthalagu A, Hayes MG, Armstrong LL, Scheftner DA, Wilkins JT, Zuvich RL, Crosslin D, Roden DM, Denny JC, et al. High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Clinical and Translational Science. 5: 394-9. PMID 23067351 DOI: 10.1111/J.1752-8062.2012.00446.X  0.778
2012 Ritchie MD. The success of pharmacogenomics in moving genetic association studies from bench to bedside: Study design and implementation of precision medicine in the post-GWAS era Human Genetics. 131: 1615-1626. PMID 22923055 DOI: 10.1007/S00439-012-1221-Z  0.388
2012 Schildcrout JS, Denny JC, Bowton E, Gregg W, Pulley JM, Basford MA, Cowan JD, Xu H, Ramirez AH, Crawford DC, Ritchie MD, Peterson JF, Masys DR, Wilke RA, Roden DM. Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clinical Pharmacology and Therapeutics. 92: 235-42. PMID 22739144 DOI: 10.1038/Clpt.2012.66  0.352
2012 Pendergrass SA, Dudek SM, Crawford DC, Ritchie MD. Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View. Biodata Mining. 5: 5. PMID 22682510 DOI: 10.1186/1756-0381-5-5  0.778
2012 Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Müller-Nurasyid M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, Dörr M, Ozaki K, Roberts JD, et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nature Genetics. 44: 670-5. PMID 22544366 DOI: 10.1038/Ng.2261  0.336
2012 Stranger BE, Björkegren J, Dolan ME, Ritchie MD. Systems and genome-wide approaches unite to provide a route to personalized medicine. Genome Medicine. 4: 29. PMID 22494390 DOI: 10.1186/Gm328  0.364
2012 Fullerton SM, Wolf WA, Brothers KB, Clayton EW, Crawford DC, Denny JC, Greenland P, Koenig BA, Leppig KA, Lindor NM, McCarty CA, McGuire AL, McPeek Hinz ER, Mirel DB, Ramos EM, ... Ritchie MD, et al. Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 14: 424-31. PMID 22361898 DOI: 10.1038/Gim.2012.15  0.388
2012 Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, et al. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics. 13: 407-18. PMID 22329724 DOI: 10.2217/Pgs.11.164  0.739
2012 Buchanan CC, Torstenson ES, Bush WS, Ritchie MD. A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data. Journal of the American Medical Informatics Association : Jamia. 19: 289-94. PMID 22319179 DOI: 10.1136/Amiajnl-2011-000652  0.75
2012 Holzinger ER, Ritchie MD. Integrating heterogeneous high-throughput data for meta-dimensional pharmacogenomics and disease-related studies. Pharmacogenomics. 13: 213-22. PMID 22256870 DOI: 10.2217/Pgs.11.145  0.832
2012 Delaney JT, Ramirez AH, Bowton E, Pulley JM, Basford MA, Schildcrout JS, Shi Y, Zink R, Oetjens M, Xu H, Cleator JH, Jahangir E, Ritchie MD, Masys DR, Roden DM, et al. Predicting clopidogrel response using DNA samples linked to an electronic health record. Clinical Pharmacology and Therapeutics. 91: 257-63. PMID 22190063 DOI: 10.1038/Clpt.2011.221  0.32
2012 Mechanic LE, Chen HS, Amos CI, Chatterjee N, Cox NJ, Divi RL, Fan R, Harris EL, Jacobs K, Kraft P, Leal SM, McAllister K, Moore JH, Paltoo DN, Province MA, ... ... Ritchie MD, et al. Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genetic Epidemiology. 36: 22-35. PMID 22147673 DOI: 10.1002/Gepi.20652  0.686
2012 Crosslin DR, McDavid A, Weston N, Nelson SC, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Pretel S, Saip A, ... Ritchie MD, et al. Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Human Genetics. 131: 639-52. PMID 22037903 DOI: 10.1007/S00439-011-1103-9  0.458
2012 Ritchie MD, Sarah PA. Abstract IA07: The phenome and pleiotropy: Dissecting the architecture of complex traits. Cancer Epidemiology and Prevention Biomarkers. 21. DOI: 10.1158/1055-9965.Gwas-Ia07  0.478
2012 Fesinmeyer MD, North KE, Ritchie MD, Lim U, Franceschini N, Wilkens LR, Gross MD, Bůžková P, Glenn K, Quibrera PM, Fernández-Rhodes L, Li Q, Fowke JH, Li R, Carlson CS, et al. Genetic Risk Factors for BMI and Obesity in an Ethnically Diverse Population: Results From the Population Architecture Using Genomics and Epidemiology (PAGE) Study Obesity. DOI: 10.1038/Oby.2012.158  0.333
2012 Thornton-Wells T, Brown-Gentry K, Baker A, Torstenson E, Dudek S, Jiang L, Ritchie M, Martin E, Pericak-Vance M, Haines J. Biological knowledge-driven approach to gene-gene interaction analysis in the Alzheimer's Disease Genetics Consortium Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1843  0.393
2011 Zuvich RL, Armstrong LL, Bielinski SJ, Bradford Y, Carlson CS, Crawford DC, Crenshaw AT, de Andrade M, Doheny KF, Haines JL, Hayes MG, Jarvik GP, Jiang L, Kullo IJ, Li R, ... ... Ritchie MD, et al. Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genetic Epidemiology. 35: 887-98. PMID 22125226 DOI: 10.1002/Gepi.20639  0.832
2011 Avery CL, He Q, North KE, Ambite JL, Boerwinkle E, Fornage M, Hindorff LA, Kooperberg C, Meigs JB, Pankow JS, Pendergrass SA, Psaty BM, Ritchie MD, Rotter JI, Taylor KD, et al. A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. Plos Genetics. 7: e1002322. PMID 22022282 DOI: 10.1371/Journal.Pgen.1002322  0.766
2011 Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, et al. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. American Journal of Human Genetics. 89: 529-42. PMID 21981779 DOI: 10.1016/J.Ajhg.2011.09.008  0.798
2011 Grady BJ, Ritchie MD. Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis. Current Pharmacogenomics and Personalized Medicine. 9: 41-66. PMID 21887206 DOI: 10.2174/187569211794728805  0.465
2011 Matise TC, Ambite JL, Buyske S, Carlson CS, Cole SA, Crawford DC, Haiman CA, Heiss G, Kooperberg C, Marchand LL, Manolio TA, North KE, Peters U, Ritchie MD, Hindorff LA, et al. The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. American Journal of Epidemiology. 174: 849-59. PMID 21836165 DOI: 10.1093/Aje/Kwr160  0.633
2011 Kullo IJ, Ding K, Shameer K, McCarty CA, Jarvik GP, Denny JC, Ritchie MD, Ye Z, Crosslin DR, Chisholm RL, Manolio TA, Chute CG. Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. American Journal of Human Genetics. 89: 131-8. PMID 21700265 DOI: 10.1016/J.Ajhg.2011.05.019  0.431
2011 Pendergrass SA, Brown-Gentry K, Dudek SM, Torstenson ES, Ambite JL, Avery CL, Buyske S, Cai C, Fesinmeyer MD, Haiman C, Heiss G, Hindorff LA, Hsu CN, Jackson RD, Kooperberg C, ... ... Ritchie MD, et al. The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery. Genetic Epidemiology. 35: 410-22. PMID 21594894 DOI: 10.1002/Gepi.20589  0.796
2011 Turner SD, Berg RL, Linneman JG, Peissig PL, Crawford DC, Denny JC, Roden DM, McCarty CA, Ritchie MD, Wilke RA. Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks Plos One. 6. PMID 21589926 DOI: 10.1371/Journal.Pone.0019586  0.671
2011 Grady BJ, Torstenson ES, Ritchie MD. The effects of linkage disequilibrium in large scale SNP datasets for MDR. Biodata Mining. 4: 11. PMID 21545716 DOI: 10.1186/1756-0381-4-11  0.374
2011 Lehr T, Yuan J, Zeumer D, Jayadev S, Ritchie MD. Rule based classifier for the analysis of gene-gene and gene-environment interactions in genetic association studies. Biodata Mining. 4: 4. PMID 21362183 DOI: 10.1186/1756-0381-4-4  0.447
2011 Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MD. A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes and Immunity. 12: 335-40. PMID 21346779 DOI: 10.1038/Gene.2011.3  0.754
2011 Yaspan BL, Bush WS, Torstenson ES, Ma D, Pericak-Vance MA, Ritchie MD, Sutcliffe JS, Haines JL. Genetic analysis of biological pathway data through genomic randomization. Human Genetics. 129: 563-71. PMID 21279722 DOI: 10.1007/S00439-011-0956-2  0.792
2011 McCarty CA, Chisholm RL, Chute CG, Kullo IJ, Jarvik GP, Larson EB, Li R, Masys DR, Ritchie MD, Roden DM, Struewing JP, Wolf WA. The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. Bmc Medical Genomics. 4: 13. PMID 21269473 DOI: 10.1186/1755-8794-4-13  0.326
2011 Turner S, Armstrong LL, Bradford Y, Carlson CS, Crawford DC, Crenshaw AT, de Andrade M, Doheny KF, Haines JL, Hayes G, Jarvik G, Jiang L, Kullo IJ, Li R, Ling H, ... ... Ritchie MD, et al. Quality control procedures for genome-wide association studies. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Unit1.19. PMID 21234875 DOI: 10.1002/0471142905.Hg0119S68  0.82
2011 Ritchie MD. Using biological knowledge to uncover the mystery in the search for epistasis in genome-wide association studies. Annals of Human Genetics. 75: 172-82. PMID 21158748 DOI: 10.1111/J.1469-1809.2010.00630.X  0.467
2011 Cattaert T, Calle ML, Dudek SM, Mahachie John JM, Van Lishout F, Urrea V, Ritchie MD, Van Steen K. Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise. Annals of Human Genetics. 75: 78-89. PMID 21158747 DOI: 10.1111/J.1469-1809.2010.00604.X  0.443
2011 Pendergrass S, Dudek SM, Roden DM, Crawford DC, Ritchie MD. Visual integration of results from a large DNA biobank (BioVU) using synthesis-view. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 265-75. PMID 21121054  0.736
2011 Grady BJ, Torstenson ES, McLaren PJ, DE Bakker PI, Haas DW, Robbins GK, Gulick RM, Haubrich R, Ribaudo H, Ritchie MD. Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 253-64. PMID 21121053 DOI: 10.1142/9789814335058_0027  0.343
2011 Zabaleta J, Camargo MC, Ritchie MD, Piazuelo MB, Sierra RA, Turner SD, Delgado A, Fontham ET, Schneider BG, Correa P, Ochoa AC. Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. International Journal of Cancer. Journal International Du Cancer. 128: 668-75. PMID 20473875 DOI: 10.1002/Ijc.25385  0.593
2011 Thornton-Wells T, Torstenson E, Dudek S, Ritchie M, Martin E, Pericak-Vance M, Haines J. Discovery and Replication of Gene-Gene Interactions in Multiple Independent Datasets from the Alzheimer Disease Genetics Consortium Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.548  0.41
2010 Pendergrass SA, Dudek SM, Crawford DC, Ritchie MD. Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis. Biodata Mining. 3: 10. PMID 21162740 DOI: 10.1186/1756-0381-3-10  0.78
2010 Holzinger ER, Buchanan CC, Dudek SM, Torstenson EC, Turner SD, Ritchie MD. Initialization Parameter Sweep in ATHENA: Optimizing Neural Networks for Detecting Gene-Gene Interactions in the Presence of Small Main Effects. Genetic and Evolutionary Computation Conference : [Proceedings] / Sponsored by Acm Sigevo. Genetic and Evolutionary Computation Conference. 12: 203-210. PMID 21152364 DOI: 10.1145/1830483.1830519  0.826
2010 Denny JC, Ritchie MD, Crawford DC, Schildcrout JS, Ramirez AH, Pulley JM, Basford MA, Masys DR, Haines JL, Roden DM. Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation. 122: 2016-21. PMID 21041692 DOI: 10.1161/Circulationaha.110.948828  0.533
2010 Ritchie MD, Bush WS. Genome simulation approaches for synthesizing in silico datasets for human genomics. Advances in Genetics. 72: 1-24. PMID 21029846 DOI: 10.1016/B978-0-12-380862-2.00001-1  0.71
2010 Turner SD, Dudek SM, Ritchie MD. ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci. Biodata Mining. 3: 5. PMID 20875103 DOI: 10.1186/1756-0381-3-5  0.665
2010 Dumitrescu L, Ritchie MD, Brown-Gentry K, Pulley JM, Basford M, Denny JC, Oksenberg JR, Roden DM, Haines JL, Crawford DC. Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 12: 648-50. PMID 20733501 DOI: 10.1097/Gim.0B013E3181Efe2Df  0.701
2010 Ribaudo HJ, Liu H, Schwab M, Schaeffeler E, Eichelbaum M, Motsinger-Reif AA, Ritchie MD, Zanger UM, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford D, Haas DW. Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study. The Journal of Infectious Diseases. 202: 717-22. PMID 20662624 DOI: 10.1086/655470  0.57
2010 Cattaert T, Urrea V, Naj AC, De Lobel L, De Wit V, Fu M, Mahachie John JM, Shen H, Calle ML, Ritchie MD, Edwards TL, Van Steen K. FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. Plos One. 5: e10304. PMID 20421984 DOI: 10.1371/Journal.Pone.0010304  0.587
2010 Canter JA, Robbins GK, Selph D, Clifford DB, Kallianpur AR, Shafer R, Levy S, Murdock DG, Ritchie MD, Haas DW, Hulgan T. African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy Journal of Infectious Diseases. 201: 1703-1707. PMID 20402593 DOI: 10.1086/652419  0.315
2010 Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. American Journal of Human Genetics. 86: 560-72. PMID 20362271 DOI: 10.1016/J.Ajhg.2010.03.003  0.583
2010 Denny JC, Ritchie MD, Basford MA, Pulley JM, Bastarache L, Brown-Gentry K, Wang D, Masys DR, Roden DM, Crawford DC. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (Oxford, England). 26: 1205-10. PMID 20335276 DOI: 10.1093/Bioinformatics/Btq126  0.431
2010 Edwards TL, Turner SD, Torstenson ES, Dudek SM, Martin ER, Ritchie MD. A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT. Plos One. 5: e9363. PMID 20186329 DOI: 10.1371/Journal.Pone.0009363  0.671
2010 Bush WS, Dudek SM, Ritchie MD. Visualizing SNP statistics in the context of linkage disequilibrium using LD-Plus. Bioinformatics (Oxford, England). 26: 578-9. PMID 20130027 DOI: 10.1093/Bioinformatics/Btp678  0.721
2010 Edwards TL, Torstensen E, Dudek S, Martin ER, Ritchie MD. A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test. Genetic Epidemiology. 34: 194-9. PMID 19697353 DOI: 10.1002/Gepi.20447  0.561
2010 McLaren GD, McCarty CA, Ritchie M, Turner S, Gordeuk VR, Garner CP, Vulpe CD, McLachlan S, Adams PC, McLaren CE. Lack of Association between Single Nucleotide Polymorphism rs3811647 in the TF Gene and Iron Status in Patients with Iron Deficiency and Control Subjects Blood. 116: 4257-4257. DOI: 10.1182/Blood.V116.21.4257.4257  0.6
2010 Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM. Erratum: Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record (American Journal of Human Genetics (2010) 86 (560-572)) American Journal of Human Genetics. 87. DOI: 10.1016/J.Ajhg.2010.06.018  0.402
2009 Turner SD, Crawford DC, Ritchie MD. Methods for optimizing statistical analyses in pharmacogenomics research. Expert Review of Clinical Pharmacology. 2: 559-570. PMID 20221410 DOI: 10.1586/Ecp.09.32  0.649
2009 Bush WS, Chen G, Torstenson ES, Ritchie MD. LD-spline: mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium. Biodata Mining. 2: 7. PMID 19954552 DOI: 10.1186/1756-0381-2-7  0.739
2009 Ritchie MD. Using prior knowledge and genome-wide association to identify pathways involved in multiple sclerosis. Genome Medicine. 1: 65. PMID 19566917 DOI: 10.1186/Gm65  0.471
2009 Bush WS, Crawford DC, Alexander C, George AL, Roden DM, Ritchie MD. Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics. 10: 1043-53. PMID 19530973 DOI: 10.2217/Pgs.09.67  0.699
2009 Bush WS, Dudek SM, Ritchie MD. Biofilter: a knowledge-integration system for the multi-locus analysis of genome-wide association studies. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 368-79. PMID 19209715  0.75
2009 Srinivasan BS, Chen J, Cheng C, Conti D, Duan S, Fridley BL, Gu X, Haines JL, Jorgenson E, Kraja A, Lasky-Su J, Li L, Rodin A, Wang D, Province M, ... Ritchie MD, et al. Methods for analysis in pharmacogenomics: lessons from the Pharmacogenetics Research Network Analysis Group. Pharmacogenomics. 10: 243-51. PMID 19207025 DOI: 10.2217/14622416.10.2.243  0.588
2009 Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 721-35. PMID 19105203 DOI: 10.1002/Ajmg.B.30899  0.648
2009 Edwards TL, Lewis K, Velez DR, Dudek S, Ritchie MD. Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models. Human Heredity. 67: 183-92. PMID 19077437 DOI: 10.1159/000181157  0.538
2009 Li C, Schwarz UI, Ritchie MD, Roden DM, Stein CM, Kurnik D. Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood. 113: 3925-30. PMID 19074728 DOI: 10.1182/Blood-2008-09-176859  0.313
2009 Moore JH, Clegg J, Marchiori E, Ritchie M, Smith S. Editorial: artificial evolution methods in the biological and biomedical sciences Journal of Artificial Evolution and Applications. 2009: 1-1. DOI: 10.1155/2009/956380  0.532
2008 Hardison NE, Fanelli TJ, Dudek SM, Reif DM, Ritchie MD, Motsinger-Reif AA. A Balanced Accuracy Fitness Function Leads to Robust Analysis using Grammatical Evolution Neural Networks in the Case of Class Imbalance. Genetic and Evolutionary Computation Conference : [Proceedings] / Sponsored by Acm Sigevo. Genetic and Evolutionary Computation Conference. 2008: 353-354. PMID 21197143 DOI: 10.1145/1389095.1389159  0.67
2008 Aguilar-Ruiz JS, Moore JH, Ritchie MD. Filling the gap between biology and computer science. Biodata Mining. 1: 1. PMID 18822148 DOI: 10.1186/1756-0381-1-1  0.551
2008 Motsinger-Reif AA, Ritchie MD. Neural networks for genetic epidemiology: past, present, and future. Biodata Mining. 1: 3. PMID 18822147 DOI: 10.1186/1756-0381-1-3  0.649
2008 Edwards TL, Wang X, Chen Q, Wormly B, Riley B, O'Neill FA, Walsh D, Ritchie MD, Kendler KS, Chen X. Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. Schizophrenia Research. 106: 208-17. PMID 18804346 DOI: 10.1016/J.Schres.2008.07.022  0.556
2008 Vineis P, Brennan P, Canzian F, Ioannidis JP, Matullo G, Ritchie M, Stromberg U, Taioli E, Thompson J. Expectations and challenges stemming from genome-wide association studies. Mutagenesis. 23: 439-44. PMID 18765424 DOI: 10.1093/Mutage/Gen042  0.472
2008 Motsinger-Reif AA, Fanelli TJ, Davis AC, Ritchie MD. Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error. Bmc Research Notes. 1: 65. PMID 18710518 DOI: 10.1186/1756-0500-1-65  0.621
2008 Motsinger-Reif AA, Reif DM, Fanelli TJ, Ritchie MD. A comparison of analytical methods for genetic association studies. Genetic Epidemiology. 32: 767-78. PMID 18561203 DOI: 10.1002/Gepi.20345  0.748
2008 Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, Schwarz UI, Ritchie MD, Stein CM, Roden DM, Smith JD, Veenstra DL, Rettie AE, Rieder MJ. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood. 112: 1022-7. PMID 18535201 DOI: 10.1182/Blood-2008-01-134247  0.42
2008 Bush WS, Edwards TL, Dudek SM, McKinney BA, Ritchie MD. Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction. Bmc Bioinformatics. 9: 238. PMID 18485205 DOI: 10.1186/1471-2105-9-238  0.74
2008 Schwarz UI, Ritchie MD, Bradford Y, Li C, Dudek SM, Frye-Anderson A, Kim RB, Roden DM, Stein CM. Genetic determinants of response to warfarin during initial anticoagulation. The New England Journal of Medicine. 358: 999-1008. PMID 18322281 DOI: 10.1056/Nejmoa0708078  0.324
2008 Motsinger-Reif AA, Dudek SM, Hahn LW, Ritchie MD. Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology. Genetic Epidemiology. 32: 325-40. PMID 18265411 DOI: 10.1002/Gepi.20307  0.623
2008 Martin ER, Turner SD, Beecham GW, Gilbert JR, Haines JL, Pericak-Vance MA, Ritchie MD. P3-240: Genome-wide analysis of gene-gene interaction in Alzheimer's disease Alzheimer's & Dementia. 4: T591-T591. DOI: 10.1016/J.Jalz.2008.05.1807  0.631
2007 Motsinger AA, Reif DM, Fanelli TJ, Davis AC, Ritchie MD. Linkage Disequilibrium in Genetic Association Studies Improves the Performance of Grammatical Evolution Neural Networks. Proceedings of the ... Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. 2007: 1-8. PMID 21572972  0.65
2007 Bush WS, Thornton-Wells TA, Ritchie MD. Association Rule Discovery Has the Ability to Model Complex Genetic Effects. Ieee Symposium On Computational Intelligence and Data Mining Ieee Symposium On Computational Intelligence and Data Mining. 2007: 624-629. PMID 20953276 DOI: 10.1109/CIDM.2007.368934  0.731
2007 Ritchie MD, Motsinger AA, Bush WS, Coffey CS, Moore JH. Genetic Programming Neural Networks: A Powerful Bioinformatics Tool for Human Genetics. Applied Soft Computing. 7: 471-479. PMID 20948988 DOI: 10.1016/J.Asoc.2006.01.013  0.794
2007 Ritchie MD, Bartlett J, Bush WS, Edwards TL, Motsinger AA, Torstenson ES. Exploring epistasis in candidate genes for rheumatoid arthritis. Bmc Proceedings. 1: S70. PMID 18466572 DOI: 10.1186/1753-6561-1-S1-S70  0.779
2007 Bartlett CW, Vieland VJ, Bartlett J, Bell JT, Bhattacharjee S, Clerget-Darpoux F, Bush WS, Edwards TL, Gao G, Halder I, Huang Y, Kotti S, Larkin EK, Li H, Motsinger AA, ... ... Ritchie MD, et al. Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky. Genetic Epidemiology. 31: S61-7. PMID 18046759 DOI: 10.1002/gepi.20281  0.728
2007 Motsinger AA, Ritchie MD, Reif DM. Novel methods for detecting epistasis in pharmacogenomics studies. Pharmacogenomics. 8: 1229-41. PMID 17924838 DOI: 10.2217/14622416.8.9.1229  0.672
2007 Ritchie MD, Edwards TL, Fanelli TJ, Motsinger AA. Genetic heterogeneity is not as threatening as you might think. Genetic Epidemiology. 31: 797-800. PMID 17654613 DOI: 10.1002/Gepi.20256  0.562
2007 Ashley-Koch AE, Jaworski J, Ma de Q, Mei H, Ritchie MD, Skaar DA, Robert Delong G, Worley G, Abramson RK, Wright HH, Cuccaro ML, Gilbert JR, Martin ER, Pericak-Vance MA. Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. Psychiatric Genetics. 17: 221-6. PMID 17621165 DOI: 10.1097/Ypg.0B013E32809C2F75  0.411
2007 Williams SM, Canter JA, Crawford DC, Moore JH, Ritchie MD, Haines JL. Problems with genome-wide association studies. Science (New York, N.Y.). 316: 1840-2. PMID 17605173  0.646
2007 Motsinger AA, Haas DW, Hulgan T, Ritchie MD. Human genomic association studies: a primer for the infectious diseases specialist. The Journal of Infectious Diseases. 195: 1737-44. PMID 17492588 DOI: 10.1086/518247  0.394
2007 Julià A, Moore J, Miquel L, Alegre C, Barceló P, Ritchie M, Marsal S. Identification of a two-loci epistatic interaction associated with susceptibility to rheumatoid arthritis through reverse engineering and multifactor dimensionality reduction. Genomics. 90: 6-13. PMID 17482423 DOI: 10.1016/J.Ygeno.2007.03.011  0.584
2007 Crawford DC, Ritchie MD, Rieder MJ. Identifying the genotype behind the phenotype: A role model found in VKORC1 and its association with warfarin dosing Pharmacogenomics. 8: 487-496. PMID 17465713 DOI: 10.2217/14622416.8.5.487  0.466
2007 Velez DR, White BC, Motsinger AA, Bush WS, Ritchie MD, Williams SM, Moore JH. A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genetic Epidemiology. 31: 306-15. PMID 17323372 DOI: 10.1002/Gepi.20211  0.753
2007 Nordgard SH, Ritchie MD, Jensrud SD, Motsinger AA, Alnaes GI, Lemmon G, Berg M, Geisler S, Moore JH, Lønning PE, Børresen-Dale AL, Kristensen VN. ABCB1 and GST polymorphisms associated with TP53 status in breast cancer. Pharmacogenetics and Genomics. 17: 127-36. PMID 17301692 DOI: 10.1097/Fpc.0B013E328011Abaa  0.645
2007 Canter JA, Summar ML, Smith HB, Rice GD, Hall LD, Ritchie MD, Motsinger AA, Christian KG, Drinkwater DC, Scholl FG, Dyer KL, Kavanaugh-McHugh AL, Barr FE. Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study. Mitochondrion. 7: 204-10. PMID 17188582 DOI: 10.1016/J.Mito.2006.11.001  0.31
2007 Tsai CT, Hwang JJ, Ritchie MD, Moore JH, Chiang FT, Lai LP, Hsu KL, Tseng CD, Lin JL, Tseng YZ. Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis. 195: 172-80. PMID 17118372 DOI: 10.1016/J.Atherosclerosis.2006.09.014  0.618
2007 Motsinger AA, Brassat D, Caillier SJ, Erlich HA, Walker K, Steiner LL, Barcellos LF, Pericak-Vance MA, Schmidt S, Gregory S, Hauser SL, Haines JL, Oksenberg JR, Ritchie MD. Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. Neurogenetics. 8: 11-20. PMID 17024427 DOI: 10.1007/S10048-006-0058-9  0.536
2006 Motsinger AA, Reif DM, Dudek SM, Ritchie MD. Understanding the Evolutionary Process of Grammatical Evolution Neural Networks for Feature Selection in Genetic Epidemiology. Proceedings of the ... Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. 2006: 1-8. PMID 20634919 DOI: 10.1109/CIBCB.2006.330945  0.607
2006 Motsinger AA, Donahue BS, Brown NJ, Roden DM, Ritchie MD. Risk factor interactions and genetic effects associated with post-operative atrial fibrillation. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 584-95. PMID 17094271  0.305
2006 Dudek SM, Motsinger AA, Velez DR, Williams SM, Ritchie MD. Data simulation software for whole-genome association and other studies in human genetics. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 499-510. PMID 17094264  0.418
2006 Motsinger AA, Ritchie MD, Shafer RW, Robbins GK, Morse GD, Labbe L, Wilkinson GR, Clifford DB, D'Aquila RT, Johnson VA, Pollard RB, Merigan TC, Hirsch MS, Donahue JP, Kim RB, et al. Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study. Pharmacogenetics and Genomics. 16: 837-45. PMID 17047492 DOI: 10.1097/01.Fpc.0000230413.97596.Fa  0.331
2006 Ritchie MD, Haas DW, Motsinger AA, Donahue JP, Erdem H, Raffanti S, Rebeiro P, George AL, Kim RB, Haines JL, Sterling TR. Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 43: 779-82. PMID 16912956 DOI: 10.1086/507101  0.48
2006 Kallianpur AR, Hulgan T, Canter JA, Ritchie MD, Haines JL, Robbins GK, Shafer RW, Clifford DB, Haas DW. Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy. Aids (London, England). 20: 1503-13. PMID 16847405 DOI: 10.1097/01.Aids.0000237366.56864.3C  0.436
2006 Motsinger AA, Ritchie MD, Dobrin SE. Clinical applications of whole-genome association studies: future applications at the bedside. Expert Review of Molecular Diagnostics. 6: 551-65. PMID 16824029 DOI: 10.1586/14737159.6.4.551  0.442
2006 Bush WS, Dudek SM, Ritchie MD. Parallel multifactor dimensionality reduction: a tool for the large-scale analysis of gene-gene interactions. Bioinformatics (Oxford, England). 22: 2173-4. PMID 16809395 DOI: 10.1093/Bioinformatics/Btl347  0.684
2006 Motsinger AA, Ritchie MD. The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction. Genetic Epidemiology. 30: 546-55. PMID 16800004 DOI: 10.1002/Gepi.20166  0.331
2006 McKinney BA, Reif DM, Ritchie MD, Moore JH. Machine learning for detecting gene-gene interactions: a review. Applied Bioinformatics. 5: 77-88. PMID 16722772 DOI: 10.2165/00822942-200605020-00002  0.737
2006 Ashley-Koch AE, Mei H, Jaworski J, Ma DQ, Ritchie MD, Menold MM, Delong GR, Abramson RK, Wright HH, Hussman JP, Cuccaro ML, Gilbert JR, Martin ER, Pericak-Vance MA. An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder. Annals of Human Genetics. 70: 281-92. PMID 16674551 DOI: 10.1111/J.1469-1809.2006.00253.X  0.43
2006 Brassat D, Motsinger AA, Caillier SJ, Erlich HA, Walker K, Steiner LL, Cree BA, Barcellos LF, Pericak-Vance MA, Schmidt S, Gregory S, Hauser SL, Haines JL, Oksenberg JR, Ritchie MD. Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. Genes and Immunity. 7: 310-5. PMID 16625214 DOI: 10.1038/Sj.Gene.6364299  0.549
2006 Motsinger AA, Ritchie MD. Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Human Genomics. 2: 318-28. PMID 16595076 DOI: 10.1186/1479-7364-2-5-318  0.415
2006 Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe T, Moore JH, Ritchie MD, Williams SM, Pezzullo JC, Sasaki M, Eisner GM, Jose PA, Felder RA. Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clinical Chemistry. 52: 352-60. PMID 16439609 DOI: 10.1373/Clinchem.2005.059139  0.567
2006 Motsinger AA, Lee SL, Mellick G, Ritchie MD. GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease. Bmc Bioinformatics. 7: 39. PMID 16436204 DOI: 10.1002/Ana.21027  0.409
2006 Takahashi H, Wilkinson GR, Nutescu EA, Morita T, Ritchie MD, Scordo MG, Pengo V, Barban M, Padrini R, Ieiri I, Otsubo K, Kashima T, Kimura S, Kijima S, Echizen H. Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans. Pharmacogenetics and Genomics. 16: 101-10. PMID 16424822 DOI: 10.1097/01.Fpc.0000184955.08453.A8  0.309
2006 Martin ER, Ritchie MD, Hahn L, Kang S, Moore JH. A novel method to identify gene-gene effects in nuclear families: The MDR-PDT Genetic Epidemiology. 30: 111-123. PMID 16374833 DOI: 10.1002/Gepi.20128  0.64
2006 Miller JE, Shivakumar MK, Risacher SL, Saykin AJ, Ritchie MD, Nho K, Kim D. P4-238: PATHWAY LEVEL CODON BIAS AMONG SYNONYMOUS RARE VARIANTS IS ASSOCIATED WITH ALZHEIMER'S DISEASE IMAGING BIOMARKER Alzheimer's & Dementia. 14: P1534-P1534. DOI: 10.1016/J.Jalz.2018.07.059  0.792
2006 Martin E, Thornton-Wells T, Edwards T, Hahn L, Bronson P, Gilbert J, Haines J, Pericak-Vance M, Ritchie M. P1-355: Joint analysis of candidate genes in AD through data reduction Alzheimer's & Dementia. 2: S201-S202. DOI: 10.1016/J.Jalz.2006.05.733  0.517
2006 Smith AH, Bush WS, Norris KJ, Ritchie MD, Roden DM, Kannankeril PJ. P1-35 Heart Rhythm. 3: S119. DOI: 10.1016/J.Hrthm.2006.02.358  0.621
2006 Motsinger AA, Dudek SM, Hahn LW, Ritchie MD. Comparison of neural network optimization approaches for studies of human genetics Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 3907: 103-114. DOI: 10.1007/11732242_10  0.424
2005 Ritchie MD, Motsinger AA. Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies. Pharmacogenomics. 6: 823-34. PMID 16296945 DOI: 10.2217/14622416.6.8.823  0.414
2005 Ritchie MD. Trends in genomic variation: a view of some of the latest technologies. Drug Discovery Today. 10: 1417-8. PMID 16243260 DOI: 10.1016/S1359-6446(05)03578-6  0.314
2005 Ritchie MD. Bioinformatics approaches for detecting gene-gene and gene-environment interactions in studies of human disease Neurosurgical Focus. 19. PMID 16241104 DOI: 10.3171/Foc.2005.19.4.3  0.37
2005 Hulgan T, Haas DW, Haines JL, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Kallianpur AR, Summar M, Canter JA. Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. Aids (London, England). 19: 1341-9. PMID 16103764 DOI: 10.1097/01.Aids.0000180786.02930.A1  0.456
2005 Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, Ritchie MD, Delong GR, Abramson RK, Wright HH, Cuccaro ML, Hussman JP, Gilbert JR, Pericak-Vance MA. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. American Journal of Human Genetics. 77: 377-88. PMID 16080114 DOI: 10.1086/433195  0.411
2005 Wilke RA, Carrillo MW, Ritchie MD. Pacific Symposium on Biocomputing--computational approaches for pharmacogenomics. Pharmacogenomics. 6: 111-3. PMID 15882130 DOI: 10.1517/14622416.6.2.111  0.33
2005 Soares ML, Coelho T, Sousa A, Batalov S, Conceição I, Sales-Luís ML, Ritchie MD, Williams SM, Nievergelt CM, Schork NJ, Saraiva MJ, Buxbaum JN. Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Human Molecular Genetics. 14: 543-53. PMID 15649951 DOI: 10.1093/Hmg/Ddi051  0.415
2005 DONAHUE B, DARBAR D, GEORGEJR A, LI C, BROWN N, RITCHIE M, RODEN D. Pharmacogenomics of atrial fibrillation Clinical Pharmacology & Therapeutics. 77: P7-P7. DOI: 10.1016/J.Clpt.2004.11.029  0.329
2005 Bush WS, Motsinger AA, Dudek SM, Ritchie MD. Can neural network constraints in GP provide power to detect genes associated with human disease Lecture Notes in Computer Science. 44-53. DOI: 10.1007/978-3-540-32003-6_5  0.724
2004 Moore JH, Hahn LW, Ritchie MD, Thornton TA, White BC. Routine Discovery of Complex Genetic Models using Genetic Algorithms. Applied Soft Computing. 4: 79-86. PMID 20948983 DOI: 10.1016/J.Asoc.2003.08.003  0.672
2004 Williams SM, Ritchie MD, Phillips JA, Dawson E, Prince M, Dzhura E, Willis A, Semenya A, Summar M, White BC, Addy JH, Kpodonu J, Wong LJ, Felder RA, Jose PA, et al. Multilocus analysis of hypertension: a hierarchical approach. Human Heredity. 57: 28-38. PMID 15133310 DOI: 10.1159/000077387  0.633
2004 Coffey CS, Hebert PR, Ritchie MD, Krumholz HM, Gaziano JM, Ridker PM, Brown NJ, Vaughan DE, Moore JH. An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. Bmc Bioinformatics. 5: 49. PMID 15119966 DOI: 10.1186/1471-2105-5-49  0.592
2004 Moore JH, Ritchie MD. STUDENTJAMA. The challenges of whole-genome approaches to common diseases. Jama. 291: 1642-3. PMID 15069055 DOI: 10.1001/Jama.291.13.1642  0.7
2004 Tsai CT, Lai LP, Lin JL, Chiang FT, Hwang JJ, Ritchie MD, Moore JH, Hsu KL, Tseng CD, Liau CS, Tseng YZ. Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation. 109: 1640-6. PMID 15023884 DOI: 10.1161/01.Cir.0000124487.36586.26  0.571
2004 Cho YM, Ritchie MD, Moore JH, Park JY, Lee KU, Shin HD, Lee HK, Park KS. Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus Diabetologia. 47: 549-554. PMID 14730379 DOI: 10.1007/S00125-003-1321-3  0.6
2003 Moore JH, Thornton TA, Ritchie MD. Basic statistics. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Appendix 3M. PMID 18428338 DOI: 10.1002/0471142905.Hga03Ms37  0.56
2003 Ritchie MD, White BC, Parker JS, Hahn LW, Moore JH. Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases. Bmc Bioinformatics. 4: 28. PMID 12846935 DOI: 10.1186/1471-2105-4-28  0.606
2003 Hahn LW, Ritchie MD, Moore JH. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (Oxford, England). 19: 376-82. PMID 12584123 DOI: 10.1093/Bioinformatics/Btf869  0.652
2003 Ritchie MD, Hahn LW, Moore JH. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genetic Epidemiology. 24: 150-7. PMID 12548676 DOI: 10.1002/Gepi.10218  0.659
2002 Moore JH, Hahn LW, Ritchie MD, Thornton TA, White BC. Application of Genetic Algorithms to the Discovery of Complex Models for Simulation Studies in Human Genetics. Proceedings of the Genetic and Evolutionary Computation Conference / Gecco. Genetic and Evolutionary Computation Conference. 2002: 1150-1155. PMID 23413413  0.602
2001 Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF, Moore JH. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer American Journal of Human Genetics. 69: 138-147. PMID 11404819 DOI: 10.1086/321276  0.648
2001 Denning C, Burl S, Ainslie A, Bracken J, Dinnyes A, Fletcher J, King T, Ritchie M, Ritchie WA, Rollo M, de Sousa P, Travers A, Wilmut I, Clark AJ. Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep. Nature Biotechnology. 19: 559-62. PMID 11385461 DOI: 10.1038/89313  0.318
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