Marylyn D. Ritchie - Publications


266 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Glessner JT, Li J, Desai A, Palmer M, Kim D, Lucas AM, Chang X, Connolly JJ, Almoguera B, Harley JB, Jarvik GP, Ritchie MD, Sleiman PMA, Roden DM, Crosslin D, et al. CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease. International Journal of Cardiology. PMID 31447229 DOI: 10.1016/j.ijcard.2019.07.058  0.96
2019 Park J, Levin MG, Haggerty CM, Hartzel DN, Judy R, Kember RL, Reza N, Ritchie MD, Owens AT, Damrauer SM, Rader DJ. A genome-first approach to aggregating rare genetic variants in LMNA for association with electronic health record phenotypes. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 31383942 DOI: 10.1038/s41436-019-0625-8  0.36
2019 Manduchi E, Orzechowski PR, Ritchie MD, Moore JH. Exploration of a diversity of computational and statistical measures of association for genome-wide genetic studies. Biodata Mining. 12: 14. PMID 31320928 DOI: 10.1186/s13040-019-0201-4  0.92
2019 Namjou B, Lingren T, Huang Y, Parameswaran S, Cobb BL, Stanaway IB, Connolly JJ, Mentch FD, Benoit B, Niu X, Wei WQ, Carroll RJ, Pacheco JA, Harley ITW, Divanovic S, ... ... Ritchie MD, et al. GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. Bmc Medicine. 17: 135. PMID 31311600 DOI: 10.1186/s12916-019-1364-z  0.96
2019 Sangkuhl K, Whirl-Carrillo M, Whaley RM, Woon M, Lavertu A, Altman RB, Carter L, Verma A, Ritchie MD, Klein TE. Pharmacogenomics Clinical Annotation Tool (PharmCAT). Clinical Pharmacology and Therapeutics. PMID 31306493 DOI: 10.1002/cpt.1568  1
2019 Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Kirchner HL, Leader JB, Liang L, McDermott-Roe C, ... ... Ritchie MD, et al. Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants. Circulation. PMID 31216868 DOI: 10.1161/CIRCULATIONAHA.119.039573  1
2019 Miller JE, Metpally RP, Person TN, Krishnamurthy S, Dasari VR, Shivakumar M, Lavage DR, Cook AM, Carey DJ, Ritchie MD, Kim D, Gogoi R. Correction to: Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population. Bmc Medical Genomics. 12: 65. PMID 31118041 DOI: 10.1186/s12920-019-0523-6  0.96
2019 Miller JE, Veturi Y, Ritchie MD. Innovative strategies for annotating the "relationSNP" between variants and molecular phenotypes. Biodata Mining. 12: 10. PMID 31114635 DOI: 10.1186/s13040-019-0197-9  0.92
2019 Miller JE, Metpally RP, Person TN, Krishnamurthy S, Dasari VR, Shivakumar M, Lavage DR, Cook AM, Carey DJ, Ritchie MD, Kim D, Gogoi R. Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population. Bmc Medical Genomics. 12: 59. PMID 31053132 DOI: 10.1186/s12920-019-0504-9  0.96
2019 Hellwege JN, Stallings S, Torstenson ES, Carroll R, Borthwick KM, Brilliant MH, Crosslin D, Gordon A, Hripcsak G, Jarvik GP, Linneman JG, Devi P, Peissig PL, Sleiman PAM, Hakonarson H, ... Ritchie MD, et al. Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network. Scientific Reports. 9: 6077. PMID 30988330 DOI: 10.1038/s41598-019-42427-z  0.96
2019 Li B, Veturi Y, Bradford Y, Verma SS, Verma A, Lucas AM, Haas DW, Ritchie MD. Influence of tissue context on gene prioritization for predicted transcriptome-wide association studies. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 24: 296-307. PMID 30864331  1
2019 Zhang X, Veturi Y, Verma S, Bone W, Verma A, Lucas A, Hebbring S, Denny JC, Stanaway IB, Jarvik GP, Crosslin D, Larson EB, Rasmussen-Torvik L, Pendergrass SA, Smoller JW, ... ... Ritchie MD, et al. Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 24: 272-283. PMID 30864329  1
2019 Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, Larson EB, Scrol A, Jarvik GP, Crosslin DR, Leppig K, et al. A phenome-wide association study to discover pleiotropic effects of , , and . Npj Genomic Medicine. 4: 3. PMID 30774981 DOI: 10.1038/s41525-019-0078-7  1
2019 Moore JH, Boland MR, Camara PG, Chervitz H, Gonzalez G, Himes BE, Kim D, Mowery DL, Ritchie MD, Shen L, Urbanowicz RJ, Holmes JH. Preparing next-generation scientists for biomedical big data: artificial intelligence approaches. Personalized Medicine. PMID 30760118 DOI: 10.2217/pme-2018-0145  0.96
2019 Zhang X, Basile AO, Pendergrass SA, Ritchie MD. Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico. Bmc Bioinformatics. 20: 46. PMID 30669967 DOI: 10.1186/s12859-018-2591-6  1
2018 Manickam K, Buchanan AH, Schwartz MLB, Hallquist MLG, Williams JL, Rahm AK, Rocha H, Savatt JM, Evans AE, Butry LM, Lazzeri AL, Lindbuchler DM, Flansburg CN, Leeming R, Vogel VG, ... ... Ritchie MD, et al. Exome Sequencing-Based Screening for BRCA1/2 Expected Pathogenic Variants Among Adult Biobank Participants. Jama Network Open. 1: e182140. PMID 30646163 DOI: 10.1001/jamanetworkopen.2018.2140  0.76
2018 Verma A, Bang L, Miller JE, Zhang Y, Lee MTM, Zhang Y, Byrska-Bishop M, Carey DJ, Ritchie MD, Pendergrass SA, Kim D. Human-Disease Phenotype Map Derived from PheWAS across 38,682 Individuals. American Journal of Human Genetics. PMID 30598166 DOI: 10.1016/j.ajhg.2018.11.006  1
2018 Mosley JD, Benson MD, Smith JG, Melander O, Ngo D, Shaffer CM, Ferguson JF, Herzig MS, McCarty CA, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, ... ... Ritchie MD, et al. Probing the Virtual Proteome to Identify Novel Disease Biomarkers. Circulation. 138: 2469-2481. PMID 30571344 DOI: 10.1161/CIRCULATIONAHA.118.036063  0.96
2018 Verma SS, Josyula N, Verma A, Zhang X, Veturi Y, Dewey FE, Hartzel DN, Lavage DR, Leader J, Ritchie MD, Pendergrass SA. Author Correction: Rare variants in drug target genes contributing to complex diseases, phenome-wide. Scientific Reports. 8: 15911. PMID 30353015 DOI: 10.1038/s41598-018-27936-7  1
2018 Stanaway IB, Hall TO, Rosenthal EA, Palmer M, Naranbhai V, Knevel R, Namjou-Khales B, Carroll RJ, Kiryluk K, Gordon AS, Linder J, Howell KM, Mapes BM, Lin FTJ, Joo YY, ... ... Ritchie MD, et al. The eMERGE genotype set of 83,717 subjects imputed to ~40 million variants genome wide and association with the herpes zoster medical record phenotype. Genetic Epidemiology. PMID 30298529 DOI: 10.1002/gepi.22167  1
2018 Mosley JD, Feng Q, Wells QS, Van Driest SL, Shaffer CM, Edwards TL, Bastarache L, Wei WQ, Davis LK, McCarty CA, Thompson W, Chute CG, Jarvik GP, Gordon AS, Palmer MR, ... ... Ritchie MD, et al. A study paradigm integrating prospective epidemiologic cohorts and electronic health records to identify disease biomarkers. Nature Communications. 9: 3522. PMID 30166544 DOI: 10.1038/s41467-018-05624-4  0.96
2018 van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, ... ... Ritchie MD, et al. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications. 9: 2904. PMID 30046033 DOI: 10.1038/s41467-018-04766-9  0.6
2018 Gusarova V, O'Dushlaine C, Teslovich TM, Benotti PN, Mirshahi T, Gottesman O, Van Hout CV, Murray MF, Mahajan A, Nielsen JB, Fritsche L, Wulff AB, Gudbjartsson DF, Sjögren M, Emdin CA, ... ... Ritchie MD, et al. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nature Communications. 9: 2252. PMID 29899519 DOI: 10.1038/s41467-018-04611-z  0.36
2018 Haas DW, Bradford Y, Verma A, Verma SS, Eron JJ, Gulick RM, Riddler SA, Sax PE, Daar ES, Morse GD, Acosta EP, Ritchie MD. Brain neurotransmitter transporter/receptor genomics and efavirenz central nervous system adverse events. Pharmacogenetics and Genomics. PMID 29847509 DOI: 10.1097/FPC.0000000000000341  1
2018 Li R, Kim D, Wheeler HE, Dudek SM, Dolan ME, Ritchie MD. Integration of genetic and functional genomics data to uncover chemotherapeutic induced cytotoxicity. The Pharmacogenomics Journal. PMID 29795408 DOI: 10.1038/s41397-018-0024-6  0.96
2018 Verma SS, Lucas A, Zhang X, Veturi Y, Dudek S, Li B, Li R, Urbanowicz R, Moore JH, Kim D, Ritchie MD. Collective feature selection to identify crucial epistatic variants. Biodata Mining. 11: 5. PMID 29713383 DOI: 10.1186/s13040-018-0168-6  1
2018 Verma A, Bradford Y, Dudek S, Lucas AM, Verma SS, Pendergrass SA, Ritchie MD. A simulation study investigating power estimates in phenome-wide association studies. Bmc Bioinformatics. 19: 120. PMID 29618318 DOI: 10.1186/s12859-018-2135-0  1
2018 Verma A, Lucas A, Verma SS, Zhang Y, Josyula N, Khan A, Hartzel DN, Lavage DR, Leader J, Ritchie MD, Pendergrass SA. PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger. American Journal of Human Genetics. PMID 29606303 DOI: 10.1016/j.ajhg.2018.02.017  1
2018 Verma SS, Josyula N, Verma A, Zhang X, Veturi Y, Dewey FE, Hartzel DN, Lavage DR, Leader J, Ritchie MD, Pendergrass SA. Rare variants in drug target genes contributing to complex diseases, phenome-wide. Scientific Reports. 8: 4624. PMID 29545597 DOI: 10.1038/s41598-018-22834-4  1
2018 Volpi S, Bult C, Chisholm RL, Deverka PA, Ginsburg GS, Jacob HJ, Kasapi M, McLeod HL, Roden DM, Williams MS, Green ED, Lyman Rodriguez L, Aronson S, Cavallari LH, Denny JC, ... ... Ritchie MD, et al. Research directions in the clinical implementation of pharmacogenomics - An Overview of US programs and projects. Clinical Pharmacology and Therapeutics. PMID 29460415 DOI: 10.1002/cpt.1048  0.48
2018 Verma SS, Ritchie MD. Another Round of "Clue" to Uncover the Mystery of Complex Traits. Genes. 9. PMID 29370075 DOI: 10.3390/genes9020061  0.96
2018 Li B, Verma SS, Veturi YC, Verma A, Bradford Y, Haas DW, Ritchie MD. Evaluation of PrediXcan for prioritizing GWAS associations and predicting gene expression. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 23: 448-459. PMID 29218904  1
2018 Veturi Y, Ritchie MD. How powerful are summary-based methods for identifying expression-trait associations under different genetic architectures? Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 23: 228-239. PMID 29218884  0.92
2018 Basile AO, Byrska-Bishop M, Wallace J, Frase AT, Ritchie MD. Novel features and enhancements in BioBin, a tool for the biologically inspired binning and association analysis of rare variants. Bioinformatics (Oxford, England). 34: 527-529. PMID 28968757 DOI: 10.1093/bioinformatics/btx559  1
2017 Verma A, Ritchie MD. Current Scope and Challenges in Phenome-Wide Association Studies. Current Epidemiology Reports. 4: 321-329. PMID 29545989 DOI: 10.1007/s40471-017-0127-7  1
2017 Nielsen JB, Fritsche LG, Zhou W, Teslovich TM, Holmen OL, Gustafsson S, Gabrielsen ME, Schmidt EM, Beaumont R, Wolford BN, Lin M, Brummett CM, Preuss MH, Refsgaard L, Bottinger EP, ... ... Ritchie MD, et al. Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. American Journal of Human Genetics. PMID 29290336 DOI: 10.1016/j.ajhg.2017.12.003  0.36
2017 Buchanan AH, Manickam K, Meyer MN, Wagner JK, Hallquist MLG, Williams JL, Rahm AK, Williams MS, Chen ZE, Shah CK, Garg TK, Lazzeri AL, Schwartz MLB, Lindbuchler DM, Fan AL, ... ... Ritchie MD, et al. Early cancer diagnoses through BRCA1/2 screening of unselected adult biobank participants. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 29261187 DOI: 10.1038/gim.2017.145  0.36
2017 Hall MA, Wallace J, Lucas A, Kim D, Basile AO, Verma SS, McCarty CA, Brilliant MH, Peissig PL, Kitchner TE, Verma A, Pendergrass SA, Dudek SM, Moore JH, Ritchie MD. PLATO software provides analytic framework for investigating complexity beyond genome-wide association studies. Nature Communications. 8: 1167. PMID 29079728 DOI: 10.1038/s41467-017-00802-2  1
2017 Ritchie MD, Davis JR, Aschard H, Battle A, Conti D, Du M, Eskin E, Fallin MD, Hsu L, Kraft P, Moore JH, Pierce BL, Bien SA, Thomas DC, Wei P, et al. Incorporation of Biological Knowledge Into the Study of Gene-Environment Interactions. American Journal of Epidemiology. 186: 771-777. PMID 28978191 DOI: 10.1093/aje/kwx229  0.92
2017 Mechanic LE, Lindström S, Daily KM, Sieberts SK, Amos CI, Chen HS, Cox NJ, Dathe M, Feuer EJ, Guertin MJ, Hoffman J, Liu Y, Moore JH, Myers CL, Ritchie MD, et al. Up For A Challenge (U4C): Stimulating innovation in breast cancer genetic epidemiology. Plos Genetics. 13: e1006945. PMID 28957327 DOI: 10.1371/journal.pgen.1006945  0.92
2017 Holzinger ER, Verma SS, Moore CB, Hall M, De R, Gilbert-Diamond D, Lanktree MB, Pankratz N, Amuzu A, Burt A, Dale C, Dudek S, Furlong CE, Gaunt TR, Kim DS, ... ... Ritchie MD, et al. Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals. Biodata Mining. 10: 25. PMID 28770004 DOI: 10.1186/s13040-017-0145-5  0.96
2017 Li R, Kim D, Ritchie MD. Methods to analyze big data in pharmacogenomics research. Pharmacogenomics. PMID 28612644 DOI: 10.2217/pgs-2016-0152  0.96
2017 Kim D, Basile AO, Bang L, Horgusluoglu E, Lee S, Ritchie MD, Saykin AJ, Nho K. Knowledge-driven binning approach for rare variant association analysis: application to neuroimaging biomarkers in Alzheimer's disease. Bmc Medical Informatics and Decision Making. 17: 61. PMID 28539126 DOI: 10.1186/s12911-017-0454-0  1
2017 Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse S, Dansky HM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Habegger L, et al. Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. The New England Journal of Medicine. PMID 28538136 DOI: 10.1056/NEJMoa1612790  0.36
2017 Rasmussen-Torvik LJ, Almoguera B, Doheny KF, Freimuth RR, Gordon AS, Hakonarson H, Hawkins JB, Husami A, Ivacic L, Kullo IJ, Linderman MD, Manolio TA, Obeng AO, Pellegrino R, Prows CA, ... Ritchie MD, et al. Concordance between Research Sequencing and Clinical Pharmacogenetic Genotyping in the eMERGE-PGx Study. The Journal of Molecular Diagnostics : Jmd. PMID 28502727 DOI: 10.1016/j.jmoldx.2017.04.002  0.36
2017 Haggerty CM, James CA, Calkins H, Tichnell C, Leader JB, Hartzel DN, Nevius CD, Pendergrass SA, Person TN, Schwartz M, Ritchie MD, Carey DJ, Ledbetter DH, Williams MS, Dewey FE, et al. Electronic health record phenotype in subjects with genetic variants associated with arrhythmogenic right ventricular cardiomyopathy: a study of 30,716 subjects with exome sequencing. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 28471438 DOI: 10.1038/gim.2017.40  1
2017 Kim D, Volk H, Girirajan S, Pendergrass S, Hall MA, Verma SS, Schmidt RJ, Hansen RL, Ghosh D, Ludena-Rodriguez Y, Kim K, Ritchie MD, Hertz-Picciotto I, Selleck SB. The joint effect of air pollution exposure and copy number variation on risk for autism. Autism Research : Official Journal of the International Society For Autism Research. PMID 28448694 DOI: 10.1002/aur.1799  0.96
2017 Fernández-Rhodes L, Gong J, Haessler J, Franceschini N, Graff M, Nishimura KK, Wang Y, Highland HM, Yoneyama S, Bush WS, Goodloe R, Ritchie MD, Crawford D, Gross M, Fornage M, et al. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Human Genetics. PMID 28391526 DOI: 10.1007/s00439-017-1787-6  0.96
2017 Greene CS, Garmire LX, Gilbert JA, Ritchie MD, Hunter LE. Celebrating parasites. Nature Genetics. 49: 483-484. PMID 28358134 DOI: 10.1038/ng.3830  0.36
2017 Dumitrescu L, Ritchie MD, Denny JC, El Rouby NM, McDonough CW, Bradford Y, Ramirez AH, Bielinski SJ, Basford MA, Chai HS, Peissig P, Carrell D, Pathak J, Rasmussen LV, Wang X, et al. Genome-wide study of resistant hypertension identified from electronic health records. Plos One. 12: e0171745. PMID 28222112 DOI: 10.1371/journal.pone.0171745  0.96
2017 Heit JA, Armasu SM, McCauley BM, Kullo IJ, Sicotte H, Pathak J, Chute CG, Gottesman O, Bottinger EP, Denny JC, Roden DM, Li R, Ritchie MD, de Andrade M. Identification of unique venous thromboembolism-susceptibility variants in African-Americans. Thrombosis and Haemostasis. PMID 28203683 DOI: 10.1160/TH16-08-0652  0.96
2017 Verma A, Bradford Y, Verma SS, Pendergrass SA, Daar ES, Venuto C, Morse GD, Ritchie MD, Haas DW. Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202. Pharmacogenetics and Genomics. PMID 28099408 DOI: 10.1097/FPC.0000000000000263  1
2016 Kim D, Li R, Lucas A, Verma SS, Dudek SM, Ritchie MD. Using knowledge-driven genomic interactions for multi-omics data analysis: metadimensional models for predicting clinical outcomes in ovarian carcinoma. Journal of the American Medical Informatics Association : Jamia. PMID 28040685 DOI: 10.1093/jamia/ocw165  0.96
2016 Abul-Husn NS, Manickam K, Jones LK, Wright EA, Hartzel DN, Gonzaga-Jauregui C, O'Dushlaine C, Leader JB, Lester Kirchner H, Lindbuchler DM, Barr ML, Giovanni MA, Ritchie MD, Overton JD, Reid JG, et al. Genetic identification of familial hypercholesterolemia within a single U.S. health care system. Science (New York, N.Y.). 354. PMID 28008010 DOI: 10.1126/science.aaf7000  0.76
2016 Dewey FE, Murray MF, Overton JD, Habegger L, Leader JB, Fetterolf SN, O'Dushlaine C, Van Hout CV, Staples J, Gonzaga-Jauregui C, Metpally R, Pendergrass SA, Giovanni MA, Kirchner HL, Balasubramanian S, ... ... Ritchie MD, et al. Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study. Science (New York, N.Y.). 354. PMID 28008009 DOI: 10.1126/science.aaf6814  1
2016 Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, ... ... Ritchie MD, et al. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The Lancet. Diabetes & Endocrinology. PMID 27908689 DOI: 10.1016/S2213-8587(16)30396-5  0.6
2016 Jones GT, Tromp G, Kuivaniemi H, Gretarsdottir S, Baas AF, Giusti B, Strauss E, van 't Hof FN, Webb T, Erdman R, Ritchie MD, Elmore JR, Verma A, Pendergrass S, Kullo IJ, et al. Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci. Circulation Research. PMID 27899403 DOI: 10.1161/CIRCRESAHA.116.308765  1
2016 Verma SS, Lucas AM, Lavage DR, Leader JB, Metpally R, Krishnamurthy S, Dewey F, Borecki I, Lopez A, Overton J, Penn J, Reid J, Pendergrass SA, Breitwieser G, Ritchie MD. IDENTIFYING GENETIC ASSOCIATIONS WITH VARIABILITY IN METABOLIC HEALTH AND BLOOD COUNT LABORATORY VALUES: DIVING INTO THE QUANTITATIVE TRAITS BY LEVERAGING LONGITUDINAL DATA FROM AN EHR. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 533-544. PMID 27897004  1
2016 De R, Verma SS, Holzinger E, Hall M, Burt A, Carrell DS, Crosslin DR, Jarvik GP, Kuivaniemi H, Kullo IJ, Lange LA, Lanktree MB, Larson EB, North KE, Reiner AP, ... ... Ritchie MD, et al. Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts. Human Genetics. PMID 27848076 DOI: 10.1007/s00439-016-1738-7  0.96
2016 Verma SS, Cooke Bailey JN, Lucas A, Bradford Y, Linneman JG, Hauser MA, Pasquale LR, Peissig PL, Brilliant MH, McCarty CA, Haines JL, Wiggs JL, Vrabec TR, Tromp G, Ritchie MD, et al. Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium. Plos Genetics. 12: e1006186. PMID 27623284 DOI: 10.1371/journal.pgen.1006186  0.96
2016 Verma A, Verma SS, Pendergrass SA, Crawford DC, Crosslin DR, Kuivaniemi H, Bush WS, Bradford Y, Kullo I, Bielinski SJ, Li R, Denny JC, Peissig P, Hebbring S, De Andrade M, ... Ritchie MD, et al. eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants. Bmc Medical Genomics. 9: 32. PMID 27535653 DOI: 10.1186/s12920-016-0191-8  0.92
2016 Verma A, Basile AO, Bradford Y, Kuivaniemi H, Tromp G, Carey D, Gerhard GS, Crowe JE, Ritchie MD, Pendergrass SA. Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. Plos One. 11: e0160573. PMID 27508393 DOI: 10.1371/journal.pone.0160573  0.92
2016 van 't Hof FN, Ruigrok YM, Lee CH, Ripke S, Anderson G, de Andrade M, Baas AF, Blankensteijn JD, Böttinger EP, Bown MJ, Broderick J, Bijlenga P, Carrell DS, Crawford DC, Crosslin DR, ... ... Ritchie MD, et al. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. Journal of the American Heart Association. 5. PMID 27418160 DOI: 10.1161/JAHA.115.002603  0.96
2016 Hall MA, Moore JH, Ritchie MD. Embracing Complex Associations in Common Traits: Critical Considerations for Precision Medicine. Trends in Genetics : Tig. PMID 27392675 DOI: 10.1016/j.tig.2016.06.001  0.92
2016 Oetjens MT, Bush WS, Denny JC, Birdwell K, Kodaman N, Verma A, Dilks HH, Pendergrass SA, Ritchie MD, Crawford DC. Evidence for extensive pleiotropy among pharmacogenes. Pharmacogenomics. 0. PMID 27249515 DOI: 10.2217/pgs-2015-0007  0.92
2016 Li R, Dudek SM, Kim D, Hall MA, Bradford Y, Peissig PL, Brilliant MH, Linneman JG, McCarty CA, Bao L, Ritchie MD. Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network. Biodata Mining. 9: 18. PMID 27168765 DOI: 10.1186/s13040-016-0094-4  0.92
2016 Butkiewicz M, Cooke Bailey JN, Frase A, Dudek S, Yaspan BL, Ritchie MD, Pendergrass SA, Haines JL. Pathway analysis by randomization incorporating structure-PARIS: an update. Bioinformatics (Oxford, England). PMID 27153576 DOI: 10.1093/bioinformatics/btw130  1
2016 Dewey FE, Gusarova V, O'Dushlaine C, Gottesman O, Trejos J, Hunt C, Van Hout CV, Habegger L, Buckler D, Lai KV, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Ledbetter DH, et al. Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease. The New England Journal of Medicine. PMID 26933753 DOI: 10.1056/NEJMoa1510926  0.36
2016 Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, et al. The phenotypic legacy of admixture between modern humans and Neandertals. Science (New York, N.Y.). 351: 737-41. PMID 26912863 DOI: 10.1126/science.aad2149  0.96
2016 Hohman TJ, Bush WS, Jiang L, Brown-Gentry KD, Torstenson ES, Dudek SM, Mukherjee S, Naj A, Kunkle BW, Ritchie MD, Martin ER, Schellenberg GD, Mayeux R, Farrer LA, Pericak-Vance MA, et al. Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium. Neurobiology of Aging. 38: 141-50. PMID 26827652 DOI: 10.1016/j.neurobiolaging.2015.10.031  0.92
2016 Kim D, Lucas A, Glessner J, Verma SS, Bradford Y, Li R, Frase AT, Hakonarson H, Peissig P, Brilliant M, Ritchie MD. BIOFILTER AS A FUNCTIONAL ANNOTATION PIPELINE FOR COMMON AND RARE COPY NUMBER BURDEN. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 21: 357-68. PMID 26776200  0.96
2016 Basile AO, Wallace JR, Peissig P, McCarty CA, Brilliant M, Ritchie MD. KNOWLEDGE DRIVEN BINNING AND PHEWAS ANALYSIS IN MARSHFIELD PERSONALIZED MEDICINE RESEARCH PROJECT USING BIOBIN. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 21: 249-60. PMID 26776191  1
2016 Verma A, Leader JB, Verma SS, Frase A, Wallace J, Dudek S, Lavage DR, VAN Hout CV, Dewey FE, Penn J, Lopez A, Overton JD, Carey DJ, Ledbetter DH, Kirchner HL, ... Ritchie MD, et al. INTEGRATING CLINICAL LABORATORY MEASURES AND ICD-9 CODE DIAGNOSES IN PHENOME-WIDE ASSOCIATION STUDIES. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 21: 168-79. PMID 26776183  1
2016 Verma SS, Frase AT, Verma A, Pendergrass SA, Mahony S, Haas DW, Ritchie MD. PHENOME-WIDE INTERACTION STUDY (PheWIS) IN AIDS CLINICAL TRIALS GROUP DATA (ACTG). Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 21: 57-68. PMID 26776173  1
2016 Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, ... ... Ritchie MD, et al. Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records. Jama. 315: 47-57. PMID 26746457 DOI: 10.1001/jama.2015.17701  0.96
2015 Leader JB, Pendergrass SA, Verma A, Carey DJ, Hartzel DN, Ritchie MD, Kirchner HL. Contrasting Association Results between Existing PheWAS Phenotype Definition Methods and Five Validated Electronic Phenotypes. Amia ... Annual Symposium Proceedings / Amia Symposium. Amia Symposium. 2015: 824-32. PMID 26958218  1
2015 De R, Verma SS, Drenos F, Holzinger ER, Holmes MV, Hall MA, Crosslin DR, Carrell DS, Hakonarson H, Jarvik G, Larson E, Pacheco JA, Rasmussen-Torvik LJ, Moore CB, Asselbergs FW, ... ... Ritchie MD, et al. Identifying gene-gene interactions that are highly associated with Body Mass Index using Quantitative Multifactor Dimensionality Reduction (QMDR). Biodata Mining. 8: 41. PMID 26674805 DOI: 10.1186/s13040-015-0074-0  0.92
2015 Li YR, van Setten J, Verma SS, Lu Y, Holmes MV, Gao H, Lek M, Nair N, Chandrupatla H, Chang B, Karczewski KJ, Wong C, Mohebnasab M, Mukhtar E, Phillips R, ... ... Ritchie MD, et al. Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies. Genome Medicine. 7: 90. PMID 26423053 DOI: 10.1186/s13073-015-0211-x  0.96
2015 Namjou B, Marsolo K, Lingren T, Ritchie MD, Verma SS, Cobb BL, Perry C, Kitchner TE, Brilliant MH, Peissig PL, Borthwick KM, Williams MS, Grafton J, Jarvik GP, Holm IA, et al. A GWAS Study on Liver Function Test Using eMERGE Network Participants. Plos One. 10: e0138677. PMID 26413716 DOI: 10.1371/journal.pone.0138677  0.96
2015 Crosslin DR, Robertson PD, Carrell DS, Gordon AS, Hanna DS, Burt A, Fullerton SM, Scrol A, Ralston J, Leppig K, Hartzler A, Baldwin E, Andrade Md, Kullo IJ, Tromp G, ... ... Ritchie MD, et al. Prospective participant selection and ranking to maximize actionable pharmacogenetic variants and discovery in the eMERGE Network. Genome Medicine. 7: 67. PMID 26221186 DOI: 10.1186/s13073-015-0181-z  0.36
2015 Crawford DC, Goodloe R, Farber-Eger E, Boston J, Pendergrass SA, Haines JL, Ritchie MD, Bush WS. Leveraging Epidemiologic and Clinical Collections for Genomic Studies of Complex Traits. Human Heredity. 79: 137-46. PMID 26201699 DOI: 10.1159/000381805  1
2015 Pendergrass SA, Verma A, Okula A, Hall MA, Crawford DC, Ritchie MD. Phenome-Wide Association Studies: Embracing Complexity for Discovery. Human Heredity. 79: 111-23. PMID 26201697 DOI: 10.1159/000381851  1
2015 Kim D, Li R, Dudek SM, Ritchie MD. Predicting censored survival data based on the interactions between meta-dimensional omics data in breast cancer. Journal of Biomedical Informatics. PMID 26048077 DOI: 10.1016/j.jbi.2015.05.019  0.92
2015 Hall MA, Verma SS, Wallace J, Lucas A, Berg RL, Connolly J, Crawford DC, Crosslin DR, de Andrade M, Doheny KF, Haines JL, Harley JB, Jarvik GP, Kitchner T, Kuivaniemi H, ... ... Ritchie MD, et al. Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network. Genetic Epidemiology. 39: 376-84. PMID 25982363 DOI: 10.1002/gepi.21902  0.92
2015 Moore CB, Verma A, Pendergrass S, Verma SS, Johnson DH, Daar ES, Gulick RM, Haubrich R, Robbins GK, Ritchie MD, Haas DW. Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols. Open Forum Infectious Diseases. 2: ofu113. PMID 25884002 DOI: 10.1093/ofid/ofu113  0.92
2015 Ritchie MD, de Andrade M, Kuivaniemi H. The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research. Frontiers in Genetics. 6: 104. PMID 25852745 DOI: 10.3389/fgene.2015.00104  0.92
2015 Pendergrass SA, Verma SS, Hall MA, Holzinger ER, Moore CB, Wallace JR, Dudek SM, Huggins W, Kitchner T, Waudby C, Berg R, Mccarty CA, Ritchie MD. Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using biofilter, and gene-environment interactions using the Phenx Toolkit*. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 495-505. PMID 25741542  1
2015 Kim D, Li R, Dudek SM, Wallace JR, Ritchie MD. Binning somatic mutations based on biological knowledge for predicting survival: an application in renal cell carcinoma. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 96-107. PMID 25592572  0.92
2015 Ritchie MD, Holzinger ER, Li R, Pendergrass SA, Kim D. Methods of integrating data to uncover genotype-phenotype interactions. Nature Reviews. Genetics. 16: 85-97. PMID 25582081 DOI: 10.1038/nrg3868  0.92
2015 Ritchie MD. Finding the epistasis needles in the genome-wide haystack. Methods in Molecular Biology (Clifton, N.J.). 1253: 19-33. PMID 25403525 DOI: 10.1007/978-1-4939-2155-3_2  0.92
2015 Chen HS, Hutter CM, Mechanic LE, Amos CI, Bafna V, Hauser ER, Hernandez RD, Li C, Liberles DA, McAllister K, Moore JH, Paltoo DN, Papanicolaou GJ, Peng B, Ritchie MD, et al. Genetic simulation tools for post-genome wide association studies of complex diseases. Genetic Epidemiology. 39: 11-9. PMID 25371374 DOI: 10.1002/gepi.21870  0.92
2015 Kim D, Joung JG, Sohn KA, Shin H, Park YR, Ritchie MD, Kim JH. Knowledge boosting: a graph-based integration approach with multi-omics data and genomic knowledge for cancer clinical outcome prediction. Journal of the American Medical Informatics Association : Jamia. 22: 109-20. PMID 25002459 DOI: 10.1136/amiajnl-2013-002481  0.92
2014 Jeff JM, Brown-Gentry K, Goodloe R, Ritchie MD, Denny JC, Kho AN, Armstrong LL, McClellan B, Mayo P, Allen M, Jin H, Gillani NB, Schnetz-Boutaud N, Dilks HH, Basford MA, et al. Replication of SCN5A Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies. Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. Evobio (Conference), Author. 2014: 939-951. PMID 25590050 DOI: 10.1007/978-3-662-45523-4_76  0.92
2014 Verma SS, de Andrade M, Tromp G, Kuivaniemi H, Pugh E, Namjou-Khales B, Mukherjee S, Jarvik GP, Kottyan LC, Burt A, Bradford Y, Armstrong GD, Derr K, Crawford DC, Haines JL, ... ... Ritchie MD, et al. Imputation and quality control steps for combining multiple genome-wide datasets. Frontiers in Genetics. 5: 370. PMID 25566314 DOI: 10.3389/fgene.2014.00370  0.92
2014 Chhibber A, Kroetz DL, Tantisira KG, McGeachie M, Cheng C, Plenge R, Stahl E, Sadee W, Ritchie MD, Pendergrass SA. Genomic architecture of pharmacological efficacy and adverse events. Pharmacogenomics. 15: 2025-48. PMID 25521360 DOI: 10.2217/pgs.14.144  0.92
2014 Namjou B, Marsolo K, Caroll RJ, Denny JC, Ritchie MD, Verma SS, Lingren T, Porollo A, Cobb BL, Perry C, Kottyan LC, Rothenberg ME, Thompson SD, Holm IA, Kohane IS, et al. Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. Frontiers in Genetics. 5: 401. PMID 25477900 DOI: 10.3389/fgene.2014.00401  0.92
2014 Hall MA, Verma A, Brown-Gentry KD, Goodloe R, Boston J, Wilson S, McClellan B, Sutcliffe C, Dilks HH, Gillani NB, Jin H, Mayo P, Allen M, Schnetz-Boutaud N, Crawford DC, ... Ritchie MD, et al. Detection of pleiotropy through a Phenome-wide association study (PheWAS) of epidemiologic data as part of the Environmental Architecture for Genes Linked to Environment (EAGLE) study. Plos Genetics. 10: e1004678. PMID 25474351 DOI: 10.1371/journal.pgen.1004678  0.92
2014 Malinowski JR, Denny JC, Bielinski SJ, Basford MA, Bradford Y, Peissig PL, Carrell D, Crosslin DR, Pathak J, Rasmussen L, Pacheco J, Kho A, Newton KM, Li R, Kullo IJ, ... ... Ritchie MD, et al. Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. Plos One. 9: e111301. PMID 25436638 DOI: 10.1371/journal.pone.0111301  0.92
2014 Crosslin DR, Tromp G, Burt A, Kim DS, Verma SS, Lucas AM, Bradford Y, Crawford DC, Armasu SM, Heit JA, Hayes MG, Kuivaniemi H, Ritchie MD, Jarvik GP, de Andrade M, et al. Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records. Frontiers in Genetics. 5: 352. PMID 25414722 DOI: 10.3389/fgene.2014.00352  0.92
2014 Ritchie MD, Verma SS, Hall MA, Goodloe RJ, Berg RL, Carrell DS, Carlson CS, Chen L, Crosslin DR, Denny JC, Jarvik G, Li R, Linneman JG, Pathak J, Peissig P, et al. Electronic medical records and genomics (eMERGE) network exploration in cataract: several new potential susceptibility loci. Molecular Vision. 20: 1281-95. PMID 25352737  0.92
2014 Barrie ES, Weinshenker D, Verma A, Pendergrass SA, Lange LA, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, et al. Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity. Circulation Research. 115: 1017-25. PMID 25326128 DOI: 10.1161/CIRCRESAHA.116.304398  0.92
2014 Kim D, Li R, Dudek SM, Frase AT, Pendergrass SA, Ritchie MD. Knowledge-driven genomic interactions: an application in ovarian cancer. Biodata Mining. 7: 20. PMID 25214892 DOI: 10.1186/1756-0381-7-20  0.92
2014 Restrepo NA, Spencer KL, Goodloe R, Garrett TA, Heiss G, Bůžková P, Jorgensen N, Jensen RA, Matise TC, Hindorff LA, Klein BE, Klein R, Wong TY, Cheng CY, Cornes BK, ... ... Ritchie MD, et al. Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study. Investigative Ophthalmology & Visual Science. 55: 6839-50. PMID 25205864 DOI: 10.1167/iovs.14-14246  0.92
2014 Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, et al. Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Frontiers in Genetics. 5: 250. PMID 25177340 DOI: 10.3389/fgene.2014.00250  0.92
2014 Ciesielski TH, Pendergrass SA, White MJ, Kodaman N, Sobota RS, Huang M, Bartlett J, Li J, Pan Q, Gui J, Selleck SB, Amos CI, Ritchie MD, Moore JH, Williams SM. Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors. Biodata Mining. 7: 10. PMID 25071867 DOI: 10.1186/1756-0381-7-10  0.92
2014 Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD. eMERGEing progress in genomics-the first seven years. Frontiers in Genetics. 5: 184. PMID 24987407 DOI: 10.3389/fgene.2014.00184  0.92
2014 Kraja AT, Chasman DI, North KE, Reiner AP, Yanek LR, Kilpeläinen TO, Smith JA, Dehghan A, Dupuis J, Johnson AD, Feitosa MF, Tekola-Ayele F, Chu AY, Nolte IM, Dastani Z, ... ... Ritchie MD, et al. Pleiotropic genes for metabolic syndrome and inflammation. Molecular Genetics and Metabolism. 112: 317-38. PMID 24981077 DOI: 10.1016/j.ymgme.2014.04.007  0.92
2014 Sun X, Lu Q, Mukherjee S, Mukheerjee S, Crane PK, Elston R, Ritchie MD. Analysis pipeline for the epistasis search - statistical versus biological filtering. Frontiers in Genetics. 5: 106. PMID 24817878 DOI: 10.3389/fgene.2014.00106  0.92
2014 Jeff JM, Armstrong LL, Ritchie MD, Denny JC, Kho AN, Basford MA, Wolf WA, Pacheco JA, Li R, Chisholm RL, Roden DM, Hayes MG, Crawford DC. Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans. Plos One. 9: e86931. PMID 24595071 DOI: 10.1371/journal.pone.0086931  0.92
2014 Kim D, Shin H, Sohn KA, Verma A, Ritchie MD, Kim JH. Incorporating inter-relationships between different levels of genomic data into cancer clinical outcome prediction. Methods (San Diego, Calif.). 67: 344-53. PMID 24561168 DOI: 10.1016/j.ymeth.2014.02.003  0.92
2014 Johnson DH, Venuto C, Ritchie MD, Morse GD, Daar ES, McLaren PJ, Haas DW. Genomewide association study of atazanavir pharmacokinetics and hyperbilirubinemia in AIDS Clinical Trials Group protocol A5202. Pharmacogenetics and Genomics. 24: 195-203. PMID 24557078 DOI: 10.1097/FPC.0000000000000034  0.92
2014 McCarty CA, Berg R, Rottscheit CM, Waudby CJ, Kitchner T, Brilliant M, Ritchie MD. Validation of PhenX measures in the personalized medicine research project for use in gene/environment studies. Bmc Medical Genomics. 7: 3. PMID 24423110 DOI: 10.1186/1755-8794-7-3  0.92
2014 Hall MA, Dudek SM, Goodloe R, Crawford DC, Pendergrass SA, Peissig P, Brilliant M, McCarty CA, Ritchie MD. Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield Personalized Medicine Research Project Biobank. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 200-11. PMID 24297547  0.92
2014 Holzinger ER, Dudek SM, Frase AT, Pendergrass SA, Ritchie MD. ATHENA: the analysis tool for heritable and environmental network associations. Bioinformatics (Oxford, England). 30: 698-705. PMID 24149050 DOI: 10.1093/bioinformatics/btt572  0.92
2014 Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, et al. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Human Genetics. 133: 95-109. PMID 24026423 DOI: 10.1007/s00439-013-1355-7  0.92
2013 Kim D, Kim S, Risacher SL, Shen L, Ritchie MD, Weiner MW, Saykin AJ, Nho K. A Graph-Based Integration of Multimodal Brain Imaging Data for the Detection of Early Mild Cognitive Impairment (E-MCI). Multimodal Brain Image Analysis : Third International Workshop, Mbia 2013, Held in Conjunction With Miccai 2013, Nagoya, Japan, September 22, 2013 : Proceedings / Li Shen, Tianming Liu, Pew-Thian Yap, Heng Huang, Dinggang Shen, Carl-Fre.... 8159: 159-169. PMID 25383392 DOI: 10.1007/978-3-319-02126-3_16  0.92
2013 Moore CB, Wallace JR, Wolfe DJ, Frase AT, Pendergrass SA, Weiss KM, Ritchie MD. Low frequency variants, collapsed based on biological knowledge, uncover complexity of population stratification in 1000 genomes project data. Plos Genetics. 9: e1003959. PMID 24385916 DOI: 10.1371/journal.pgen.1003959  1
2013 Pendergrass SA, Frase A, Wallace J, Wolfe D, Katiyar N, Moore C, Ritchie MD. Genomic analyses with biofilter 2.0: knowledge driven filtering, annotation, and model development. Biodata Mining. 6: 25. PMID 24378202 DOI: 10.1186/1756-0381-6-25  1
2013 Kim D, Li R, Dudek SM, Ritchie MD. ATHENA: Identifying interactions between different levels of genomic data associated with cancer clinical outcomes using grammatical evolution neural network. Biodata Mining. 6: 23. PMID 24359638 DOI: 10.1186/1756-0381-6-23  0.92
2013 Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, ... ... Ritchie MD, et al. Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data. Plos One. 8: e81503. PMID 24349080 DOI: 10.1371/journal.pone.0081503  0.92
2013 Denny JC, Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM, Ramirez AH, Bowton E, Basford MA, Carrell DS, Peissig PL, Kho AN, Pacheco JA, et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nature Biotechnology. 31: 1102-10. PMID 24270849 DOI: 10.1038/nbt.2749  0.92
2013 Behr ER, Ritchie MD, Tanaka T, Kääb S, Crawford DC, Nicoletti P, Floratos A, Sinner MF, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Zumhagen S, Guicheney P, Bishopric NH, et al. Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. Plos One. 8: e78511. PMID 24223155 DOI: 10.1371/journal.pone.0078511  0.92
2013 Wolfe D, Dudek S, Ritchie MD, Pendergrass SA. Visualizing genomic information across chromosomes with PhenoGram. Biodata Mining. 6: 18. PMID 24131735 DOI: 10.1186/1756-0381-6-18  1
2013 Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S, Bůžková P, Fornage M, Gross M, Pankratz N, Pankow JS, Schreiner PJ, Cooper R, ... ... Ritchie MD, et al. Fine Mapping and Identification of BMI Loci in African Americans. American Journal of Human Genetics. 93: 661-71. PMID 24094743 DOI: 10.1016/j.ajhg.2013.08.012  0.92
2013 Carlson CS, Matise TC, North KE, Haiman CA, Fesinmeyer MD, Buyske S, Schumacher FR, Peters U, Franceschini N, Ritchie MD, Duggan DJ, Spencer KL, Dumitrescu L, Eaton CB, Thomas F, et al. Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. Plos Biology. 11: e1001661. PMID 24068893 DOI: 10.1371/journal.pbio.1001661  0.92
2013 Hulgan T, Stein JH, Cotter BR, Murdock DG, Ritchie MD, Dube MP, Gerschenson M, Haas DW, Torriani FJ. Mitochondrial DNA variation and changes in adiponectin and endothelial function in HIV-infected adults after antiretroviral therapy initiation. Aids Research and Human Retroviruses. 29: 1293-9. PMID 23944767 DOI: 10.1089/aid.2013.0079  0.92
2013 Moore JH, Ritchie MD. The central role of biological data mining in connecting diverse disciplines. Biodata Mining. 6: 14. PMID 23937773 DOI: 10.1186/1756-0381-6-14  0.92
2013 Park SL, Cheng I, Pendergrass SA, Kucharska-Newton AM, Lim U, Ambite JL, Caberto CP, Monroe KR, Schumacher F, Hindorff LA, Oetjens MT, Wilson S, Goodloe RJ, Love SA, Henderson BE, ... ... Ritchie MD, et al. Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. American Journal of Epidemiology. 178: 780-90. PMID 23820787 DOI: 10.1093/aje/kwt028  0.92
2013 Moore CB, Wallace JR, Frase AT, Pendergrass SA, Ritchie MD. BioBin: a bioinformatics tool for automating the binning of rare variants using publicly available biological knowledge. Bmc Medical Genomics. 6: S6. PMID 23819467 DOI: 10.1186/1755-8794-6-S2-S6  1
2013 McDavid A, Crane PK, Newton KM, Crosslin DR, McCormick W, Weston N, Ehrlich K, Hart E, Harrison R, Kukull WA, Rottscheit C, Peissig P, Stefanski E, McCarty CA, Zuvich RL, ... Ritchie MD, et al. Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records. Plos One. 8: e63481. PMID 23762230 DOI: 10.1371/journal.pone.0063481  0.92
2013 Gottesman O, Kuivaniemi H, Tromp G, Faucett WA, Li R, Manolio TA, Sanderson SC, Kannry J, Zinberg R, Basford MA, Brilliant M, Carey DJ, Chisholm RL, Chute CG, Connolly JJ, ... ... Ritchie MD, et al. The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 15: 761-71. PMID 23743551 DOI: 10.1038/gim.2013.72  0.92
2013 Fesinmeyer MD, North KE, Ritchie MD, Lim U, Franceschini N, Wilkens LR, Gross MD, Bůžková P, Glenn K, Quibrera PM, Fernández-Rhodes L, Li Q, Fowke JH, Li R, Carlson CS, et al. Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring, Md.). 21: 835-46. PMID 23712987 DOI: 10.1002/oby.20268  0.92
2013 Ding K, de Andrade M, Manolio TA, Crawford DC, Rasmussen-Torvik LJ, Ritchie MD, Denny JC, Masys DR, Jouni H, Pachecho JA, Kho AN, Roden DM, Chisholm R, Kullo IJ. Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study. G3 (Bethesda, Md.). 3: 1061-8. PMID 23696099 DOI: 10.1534/g3.113.006452  0.92
2013 Oetjens MT, Denny JC, Ritchie MD, Gillani NB, Richardson DM, Restrepo NA, Pulley JM, Dilks HH, Basford MA, Bowton E, Masys DR, Wilke RA, Roden DM, Crawford DC. Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Pharmacogenomics. 14: 735-44. PMID 23651022 DOI: 10.2217/pgs.13.64  0.92
2013 Zhang L, Buzkova P, Wassel CL, Roman MJ, North KE, Crawford DC, Boston J, Brown-Gentry KD, Cole SA, Deelman E, Goodloe R, Wilson S, Heiss G, Jenny NS, Jorgensen NW, ... ... Ritchie MD, et al. Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study. Atherosclerosis. 228: 390-9. PMID 23587283 DOI: 10.1016/j.atherosclerosis.2013.02.038  0.92
2013 Jeff JM, Ritchie MD, Denny JC, Kho AN, Ramirez AH, Crosslin D, Armstrong L, Basford MA, Wolf WA, Pacheco JA, Chisholm RL, Roden DM, Hayes MG, Crawford DC. Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Annals of Human Genetics. 77: 321-32. PMID 23534349 DOI: 10.1111/ahg.12023  0.92
2013 McGeachie MJ, Stahl EA, Himes BE, Pendergrass SA, Lima JJ, Irvin CG, Peters SP, Ritchie MD, Plenge RM, Tantisira KG. Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. Pharmacogenetics and Genomics. 23: 324-8. PMID 23532052 DOI: 10.1097/FPC.0b013e3283607acf  0.92
2013 Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout JS, Bastarache L, Ramirez AH, Mosley JD, Pulley JM, Basford MA, Bradford Y, Rasmussen LV, Pathak J, Chute CG, Kullo IJ, et al. Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation. 127: 1377-85. PMID 23463857 DOI: 10.1161/CIRCULATIONAHA.112.000604  0.92
2013 Spencer KL, Malinowski J, Carty CL, Franceschini N, Fernández-Rhodes L, Young A, Cheng I, Ritchie MD, Haiman CA, Wilkens L, Chunyuanwu, Matise TC, Carlson CS, Brennan K, Park A, et al. Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. Plos One. 8: e55258. PMID 23424626 DOI: 10.1371/journal.pone.0055258  0.92
2013 Holzinger ER, Dudek SM, Frase AT, Krauss RM, Medina MW, Ritchie MD. ATHENA: a tool for meta-dimensional analysis applied to genotypes and gene expression data to predict HDL cholesterol levels. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 385-96. PMID 23424143  0.92
2013 Bush WS, Boston J, Pendergrass SA, Dumitrescu L, Goodloe R, Brown-Gentry K, Wilson S, McClellan B, Torstenson E, Basford MA, Spencer KL, Ritchie MD, Crawford DC. Enabling high-throughput genotype-phenotype associations in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 373-84. PMID 23424142  0.92
2013 Moore CB, Wallace JR, Frase AT, Pendergrass SA, Ritchie MD. Using BioBin to explore rare variant population stratification. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 332-43. PMID 23424138  1
2013 Crawford DC, Goodloe R, Brown-Gentry K, Wilson S, Roberson J, Gillani NB, Ritchie MD, Dilks HH, Bush WS. Characterization of the Metabochip in diverse populations from the International HapMap Project in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 188-99. PMID 23424124  0.76
2013 Pendergrass SA, Verma SS, Holzinger ER, Moore CB, Wallace J, Dudek SM, Huggins W, Kitchner T, Waudby C, Berg R, McCarty CA, Ritchie MD. Next-generation analysis of cataracts: determining knowledge driven gene-gene interactions using Biofilter, and gene-environment interactions using the PhenX Toolkit. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 147-58. PMID 23424120  0.92
2013 Pendergrass SA, Brown-Gentry K, Dudek S, Frase A, Torstenson ES, Goodloe R, Ambite JL, Avery CL, Buyske S, Bůžková P, Deelman E, Fesinmeyer MD, Haiman CA, Heiss G, Hindorff LA, ... ... Ritchie MD, et al. Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. Plos Genetics. 9: e1003087. PMID 23382687 DOI: 10.1371/journal.pgen.1003087  0.92
2013 Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, et al. Genetic variation associated with circulating monocyte count in the eMERGE Network. Human Molecular Genetics. 22: 2119-27. PMID 23314186 DOI: 10.1093/hmg/ddt010  0.92
2013 Fesinmeyer MD, North KE, Lim U, Bůžková P, Crawford DC, Haessler J, Gross MD, Fowke JH, Goodloe R, Love SA, Graff M, Carlson CS, Kuller LH, Matise TC, Hong CP, ... ... Ritchie MD, et al. Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. Bmc Medical Genetics. 14: 6. PMID 23311614 DOI: 10.1186/1471-2350-14-6  0.92
2012 Holzinger ER, Grady B, Ritchie MD, Ribaudo HJ, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford DB, Daar ES, McLaren P, Haas DW. Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants. Pharmacogenetics and Genomics. 22: 858-67. PMID 23080225 DOI: 10.1097/FPC.0b013e32835a450b  0.92
2012 Holzinger ER, Hulgan T, Ellis RJ, Samuels DC, Ritchie MD, Haas DW, Kallianpur AR, Bloss CS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, et al. Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. Journal of Neurovirology. 18: 511-20. PMID 23073667 DOI: 10.1007/s13365-012-0133-y  0.92
2012 Rasmussen-Torvik LJ, Pacheco JA, Wilke RA, Thompson WK, Ritchie MD, Kho AN, Muthalagu A, Hayes MG, Armstrong LL, Scheftner DA, Wilkins JT, Zuvich RL, Crosslin D, Roden DM, Denny JC, et al. High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Clinical and Translational Science. 5: 394-9. PMID 23067351 DOI: 10.1111/j.1752-8062.2012.00446.x  0.92
2012 Ritchie MD. The success of pharmacogenomics in moving genetic association studies from bench to bedside: Study design and implementation of precision medicine in the post-GWAS era Human Genetics. 131: 1615-1626. PMID 22923055 DOI: 10.1007/s00439-012-1221-z  0.92
2012 Ritchie MD, Rowan S, Kucera G, Stubblefield T, Blair M, Carter S, Roden DM, Darbar D. Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation. Journal of the American College of Cardiology. 60: 1173-81. PMID 22818067 DOI: 10.1016/j.jacc.2012.04.030  0.92
2012 Pendergrass SA, Dudek SM, Crawford DC, Ritchie MD. Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View. Biodata Mining. 5: 5. PMID 22682510 DOI: 10.1186/1756-0381-5-5  0.92
2012 Ding K, Shameer K, Jouni H, Masys DR, Jarvik GP, Kho AN, Ritchie MD, McCarty CA, Chute CG, Manolio TA, Kullo IJ. Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits. Mayo Clinic Proceedings. 87: 461-74. PMID 22560525 DOI: 10.1016/j.mayocp.2012.01.016  0.92
2012 Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Müller-Nurasyid M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, Dörr M, Ozaki K, Roberts JD, et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nature Genetics. 44: 670-5. PMID 22544366 DOI: 10.1038/ng.2261  0.92
2012 Stranger BE, Björkegren J, Dolan ME, Ritchie MD. Systems and genome-wide approaches unite to provide a route to personalized medicine. Genome Medicine. 4: 29. PMID 22494390 DOI: 10.1186/gm328  0.92
2012 Fullerton SM, Wolf WA, Brothers KB, Clayton EW, Crawford DC, Denny JC, Greenland P, Koenig BA, Leppig KA, Lindor NM, McCarty CA, McGuire AL, McPeek Hinz ER, Mirel DB, Ramos EM, ... Ritchie MD, et al. Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 14: 424-31. PMID 22361898 DOI: 10.1038/gim.2012.15  0.92
2012 Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, et al. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics. 13: 407-18. PMID 22329724 DOI: 10.2217/pgs.11.164  0.92
2012 Buchanan CC, Torstenson ES, Bush WS, Ritchie MD. A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data. Journal of the American Medical Informatics Association : Jamia. 19: 289-94. PMID 22319179 DOI: 10.1136/amiajnl-2011-000652  0.76
2012 Holzinger ER, Ritchie MD. Integrating heterogeneous high-throughput data for meta-dimensional pharmacogenomics and disease-related studies. Pharmacogenomics. 13: 213-22. PMID 22256870 DOI: 10.2217/pgs.11.145  0.92
2012 Mechanic LE, Chen HS, Amos CI, Chatterjee N, Cox NJ, Divi RL, Fan R, Harris EL, Jacobs K, Kraft P, Leal SM, McAllister K, Moore JH, Paltoo DN, Province MA, ... ... Ritchie MD, et al. Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genetic Epidemiology. 36: 22-35. PMID 22147673 DOI: 10.1002/gepi.20652  0.92
2012 Birdwell KA, Grady B, Choi L, Xu H, Bian A, Denny JC, Jiang M, Vranic G, Basford M, Cowan JD, Richardson DM, Robinson MP, Ikizler TA, Ritchie MD, Stein CM, et al. The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenetics and Genomics. 22: 32-42. PMID 22108237 DOI: 10.1097/FPC.0b013e32834e1641  0.92
2012 Kääb S, Crawford DC, Sinner MF, Behr ER, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Guicheney P, Bishopric NH, Myerburg RJ, Schott JJ, Pfeufer A, Beckmann BM, Martens E, ... ... Ritchie MD, et al. A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circulation. Cardiovascular Genetics. 5: 91-9. PMID 22100668 DOI: 10.1161/CIRCGENETICS.111.960930  0.92
2012 Crosslin DR, McDavid A, Weston N, Nelson SC, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Pretel S, Saip A, ... Ritchie MD, et al. Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Human Genetics. 131: 639-52. PMID 22037903 DOI: 10.1007/s00439-011-1103-9  0.92
2011 Haas DW, Kuritzkes DR, Ritchie MD, Amur S, Gage BF, Maartens G, Masys D, Fellay J, Phillips E, Ribaudo HJ, Freedberg KA, Petropoulos C, Manolio TA, Gulick RM, Haubrich R, et al. Pharmacogenomics of HIV therapy: summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases. Hiv Clinical Trials. 12: 277-85. PMID 22180526 DOI: 10.1310/hct1205-277  0.92
2011 Zuvich RL, Armstrong LL, Bielinski SJ, Bradford Y, Carlson CS, Crawford DC, Crenshaw AT, de Andrade M, Doheny KF, Haines JL, Hayes MG, Jarvik GP, Jiang L, Kullo IJ, Li R, ... ... Ritchie MD, et al. Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genetic Epidemiology. 35: 887-98. PMID 22125226 DOI: 10.1002/gepi.20639  0.92
2011 Avery CL, He Q, North KE, Ambite JL, Boerwinkle E, Fornage M, Hindorff LA, Kooperberg C, Meigs JB, Pankow JS, Pendergrass SA, Psaty BM, Ritchie MD, Rotter JI, Taylor KD, et al. A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. Plos Genetics. 7: e1002322. PMID 22022282 DOI: 10.1371/journal.pgen.1002322  0.92
2011 Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, et al. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. American Journal of Human Genetics. 89: 529-42. PMID 21981779 DOI: 10.1016/j.ajhg.2011.09.008  0.92
2011 Matise TC, Ambite JL, Buyske S, Carlson CS, Cole SA, Crawford DC, Haiman CA, Heiss G, Kooperberg C, Marchand LL, Manolio TA, North KE, Peters U, Ritchie MD, Hindorff LA, et al. The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. American Journal of Epidemiology. 174: 849-59. PMID 21836165 DOI: 10.1093/aje/kwr160  0.92
2011 Grady BJ, Samuels DC, Robbins GK, Selph D, Canter JA, Pollard RB, Haas DW, Shafer R, Kalams SA, Murdock DG, Ritchie MD, Hulgan T. Mitochondrial genomics and CD4 T-cell count recovery after antiretroviral therapy initiation in AIDS clinical trials group study 384 Journal of Acquired Immune Deficiency Syndromes. 58: 363-370. PMID 21792066 DOI: 10.1097/QAI.0b013e31822c688b  0.92
2011 Kullo IJ, Ding K, Shameer K, McCarty CA, Jarvik GP, Denny JC, Ritchie MD, Ye Z, Crosslin DR, Chisholm RL, Manolio TA, Chute CG. Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. American Journal of Human Genetics. 89: 131-8. PMID 21700265 DOI: 10.1016/j.ajhg.2011.05.019  0.92
2011 Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Journal of the American Medical Informatics Association : Jamia. 18: 387-91. PMID 21672908 DOI: 10.1136/amiajnl-2011-000208  0.92
2011 Turner SD, Berg RL, Linneman JG, Peissig PL, Crawford DC, Denny JC, Roden DM, McCarty CA, Ritchie MD, Wilke RA. Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks Plos One. 6. PMID 21589926 DOI: 10.1371/journal.pone.0019586  0.92
2011 Grady BJ, Torstenson ES, Ritchie MD. The effects of linkage disequilibrium in large scale SNP datasets for MDR. Biodata Mining. 4: 11. PMID 21545716 DOI: 10.1186/1756-0381-4-11  0.56
2011 Yaspan BL, Bush WS, Torstenson ES, Ma D, Pericak-Vance MA, Ritchie MD, Sutcliffe JS, Haines JL. Genetic analysis of biological pathway data through genomic randomization. Human Genetics. 129: 563-71. PMID 21279722 DOI: 10.1007/s00439-011-0956-2  0.92
2011 McCarty CA, Chisholm RL, Chute CG, Kullo IJ, Jarvik GP, Larson EB, Li R, Masys DR, Ritchie MD, Roden DM, Struewing JP, Wolf WA. The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. Bmc Medical Genomics. 4: 13. PMID 21269473 DOI: 10.1186/1755-8794-4-13  0.92
2011 Turner S, Armstrong LL, Bradford Y, Carlson CS, Crawford DC, Crenshaw AT, de Andrade M, Doheny KF, Haines JL, Hayes G, Jarvik G, Jiang L, Kullo IJ, Li R, Ling H, ... ... Ritchie MD, et al. Quality control procedures for genome-wide association studies. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Unit1.19. PMID 21234875 DOI: 10.1002/0471142905.hg0119s68  0.92
2011 Cattaert T, Calle ML, Dudek SM, Mahachie John JM, Van Lishout F, Urrea V, Ritchie MD, Van Steen K. Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise. Annals of Human Genetics. 75: 78-89. PMID 21158747 DOI: 10.1111/j.1469-1809.2010.00604.x  0.92
2011 Pendergrass S, Dudek SM, Roden DM, Crawford DC, Ritchie MD. Visual integration of results from a large DNA biobank (BioVU) using synthesis-view. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 265-75. PMID 21121054  0.92
2011 Grady BJ, Torstenson ES, McLaren PJ, DE Bakker PI, Haas DW, Robbins GK, Gulick RM, Haubrich R, Ribaudo H, Ritchie MD. Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 253-64. PMID 21121053  0.92
2011 Hulgan T, Haubrich R, Riddler SA, Tebas P, Ritchie MD, McComsey GA, Haas DW, Canter JA. European mitochondrial DNA haplogroups and metabolic changes during antiretroviral therapy in AIDS Clinical Trials Group Study A5142. Aids (London, England). 25: 37-47. PMID 20871389 DOI: 10.1097/QAD.0b013e32833f9d02  0.6
2011 Zabaleta J, Camargo MC, Ritchie MD, Piazuelo MB, Sierra RA, Turner SD, Delgado A, Fontham ET, Schneider BG, Correa P, Ochoa AC. Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians. International Journal of Cancer. Journal International Du Cancer. 128: 668-75. PMID 20473875 DOI: 10.1002/ijc.25385  0.92
2010 Pendergrass SA, Dudek SM, Crawford DC, Ritchie MD. Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis. Biodata Mining. 3: 10. PMID 21162740 DOI: 10.1186/1756-0381-3-10  0.92
2010 Holzinger ER, Buchanan CC, Dudek SM, Torstenson EC, Turner SD, Ritchie MD. Initialization Parameter Sweep in ATHENA: Optimizing Neural Networks for Detecting Gene-Gene Interactions in the Presence of Small Main Effects. Genetic and Evolutionary Computation Conference : [Proceedings] / Sponsored by Acm Sigevo. Genetic and Evolutionary Computation Conference. 12: 203-210. PMID 21152364 DOI: 10.1145/1830483.1830519  0.92
2010 Denny JC, Ritchie MD, Crawford DC, Schildcrout JS, Ramirez AH, Pulley JM, Basford MA, Masys DR, Haines JL, Roden DM. Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation. 122: 2016-21. PMID 21041692 DOI: 10.1161/CIRCULATIONAHA.110.948828  0.92
2010 Ritchie MD, Bush WS. Genome simulation approaches for synthesizing in silico datasets for human genomics. Advances in Genetics. 72: 1-24. PMID 21029846 DOI: 10.1016/B978-0-12-380862-2.00001-1  0.76
2010 Turner SD, Dudek SM, Ritchie MD. ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci. Biodata Mining. 3: 5. PMID 20875103 DOI: 10.1186/1756-0381-3-5  0.92
2010 Dumitrescu L, Ritchie MD, Brown-Gentry K, Pulley JM, Basford M, Denny JC, Oksenberg JR, Roden DM, Haines JL, Crawford DC. Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 12: 648-50. PMID 20733501 DOI: 10.1097/GIM.0b013e3181efe2df  0.92
2010 Ribaudo HJ, Liu H, Schwab M, Schaeffeler E, Eichelbaum M, Motsinger-Reif AA, Ritchie MD, Zanger UM, Acosta EP, Morse GD, Gulick RM, Robbins GK, Clifford D, Haas DW. Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study. The Journal of Infectious Diseases. 202: 717-22. PMID 20662624 DOI: 10.1086/655470  0.92
2010 Cattaert T, Urrea V, Naj AC, De Lobel L, De Wit V, Fu M, Mahachie John JM, Shen H, Calle ML, Ritchie MD, Edwards TL, Van Steen K. FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. Plos One. 5: e10304. PMID 20421984 DOI: 10.1371/journal.pone.0010304  0.92
2010 Canter JA, Robbins GK, Selph D, Clifford DB, Kallianpur AR, Shafer R, Levy S, Murdock DG, Ritchie MD, Haas DW, Hulgan T. African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy Journal of Infectious Diseases. 201: 1703-1707. PMID 20402593 DOI: 10.1086/652419  0.92
2010 Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. American Journal of Human Genetics. 86: 560-72. PMID 20362271 DOI: 10.1016/j.ajhg.2010.03.003  0.92
2010 Denny JC, Ritchie MD, Basford MA, Pulley JM, Bastarache L, Brown-Gentry K, Wang D, Masys DR, Roden DM, Crawford DC. PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (Oxford, England). 26: 1205-10. PMID 20335276 DOI: 10.1093/bioinformatics/btq126  0.76
2010 Edwards TL, Turner SD, Torstenson ES, Dudek SM, Martin ER, Ritchie MD. A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT. Plos One. 5: e9363. PMID 20186329 DOI: 10.1371/journal.pone.0009363  0.92
2010 Bush WS, Dudek SM, Ritchie MD. Visualizing SNP statistics in the context of linkage disequilibrium using LD-Plus. Bioinformatics (Oxford, England). 26: 578-9. PMID 20130027 DOI: 10.1093/bioinformatics/btp678  0.92
2010 Grady BJ, Torstenson E, Dudek SM, Giles J, Sexton D, Ritchie MD. Finding unique filter sets in PLATO: a precursor to efficient interaction analysis in GWAS data. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 315-26. PMID 19908384  0.92
2010 Edwards TL, Torstensen E, Dudek S, Martin ER, Ritchie MD. A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test. Genetic Epidemiology. 34: 194-9. PMID 19697353 DOI: 10.1002/gepi.20447  0.92
2009 Turner SD, Crawford DC, Ritchie MD. Methods for optimizing statistical analyses in pharmacogenomics research. Expert Review of Clinical Pharmacology. 2: 559-570. PMID 20221410 DOI: 10.1586/ecp.09.32  0.76
2009 Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, et al. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circulation. Cardiovascular Genetics. 2: 499-506. PMID 20031626 DOI: 10.1161/CIRCGENETICS.109.849075  0.92
2009 Bush WS, Chen G, Torstenson ES, Ritchie MD. LD-spline: mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium. Biodata Mining. 2: 7. PMID 19954552 DOI: 10.1186/1756-0381-2-7  0.76
2009 Bush WS, Crawford DC, Alexander C, George AL, Roden DM, Ritchie MD. Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics. 10: 1043-53. PMID 19530973 DOI: 10.2217/pgs.09.67  0.92
2009 Bush WS, Dudek SM, Ritchie MD. Biofilter: a knowledge-integration system for the multi-locus analysis of genome-wide association studies. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 368-79. PMID 19209715  0.92
2009 Srinivasan BS, Chen J, Cheng C, Conti D, Duan S, Fridley BL, Gu X, Haines JL, Jorgenson E, Kraja A, Lasky-Su J, Li L, Rodin A, Wang D, Province M, ... Ritchie MD, et al. Methods for analysis in pharmacogenomics: lessons from the Pharmacogenetics Research Network Analysis Group. Pharmacogenomics. 10: 243-51. PMID 19207025 DOI: 10.2217/14622416.10.2.243  0.92
2009 Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 721-35. PMID 19105203 DOI: 10.1002/ajmg.b.30899  0.92
2009 Edwards TL, Lewis K, Velez DR, Dudek S, Ritchie MD. Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models. Human Heredity. 67: 183-92. PMID 19077437 DOI: 10.1159/000181157  0.92
2008 Hardison NE, Fanelli TJ, Dudek SM, Reif DM, Ritchie MD, Motsinger-Reif AA. A Balanced Accuracy Fitness Function Leads to Robust Analysis using Grammatical Evolution Neural Networks in the Case of Class Imbalance. Genetic and Evolutionary Computation Conference : [Proceedings] / Sponsored by Acm Sigevo. Genetic and Evolutionary Computation Conference. 2008: 353-354. PMID 21197143 DOI: 10.1145/1389095.1389159  0.92
2008 Aguilar-Ruiz JS, Moore JH, Ritchie MD. Filling the gap between biology and computer science. Biodata Mining. 1: 1. PMID 18822148 DOI: 10.1186/1756-0381-1-1  0.92
2008 Motsinger-Reif AA, Ritchie MD. Neural networks for genetic epidemiology: past, present, and future. Biodata Mining. 1: 3. PMID 18822147 DOI: 10.1186/1756-0381-1-3  0.92
2008 Edwards TL, Wang X, Chen Q, Wormly B, Riley B, O'Neill FA, Walsh D, Ritchie MD, Kendler KS, Chen X. Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia. Schizophrenia Research. 106: 208-17. PMID 18804346 DOI: 10.1016/j.schres.2008.07.022  0.92
2008 Motsinger-Reif AA, Fanelli TJ, Davis AC, Ritchie MD. Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error. Bmc Research Notes. 1: 65. PMID 18710518 DOI: 10.1186/1756-0500-1-65  0.92
2008 Motsinger-Reif AA, Reif DM, Fanelli TJ, Ritchie MD. A comparison of analytical methods for genetic association studies. Genetic Epidemiology. 32: 767-78. PMID 18561203 DOI: 10.1002/gepi.20345  0.92
2008 Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, Schwarz UI, Ritchie MD, Stein CM, Roden DM, Smith JD, Veenstra DL, Rettie AE, Rieder MJ. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood. 112: 1022-7. PMID 18535201 DOI: 10.1182/blood-2008-01-134247  0.92
2008 Bush WS, Edwards TL, Dudek SM, McKinney BA, Ritchie MD. Alternative contingency table measures improve the power and detection of multifactor dimensionality reduction. Bmc Bioinformatics. 9: 238. PMID 18485205 DOI: 10.1186/1471-2105-9-238  0.92
2008 Schwarz UI, Ritchie MD, Bradford Y, Li C, Dudek SM, Frye-Anderson A, Kim RB, Roden DM, Stein CM. Genetic determinants of response to warfarin during initial anticoagulation. The New England Journal of Medicine. 358: 999-1008. PMID 18322281 DOI: 10.1056/NEJMoa0708078  0.92
2008 Darbar D, Kimbrough J, Jawaid A, McCray R, Ritchie MD, Roden DM. Persistent atrial fibrillation is associated with reduced risk of torsades de pointes in patients with drug-induced long QT syndrome. Journal of the American College of Cardiology. 51: 836-42. PMID 18294569 DOI: 10.1016/j.jacc.2007.09.066  0.92
2008 Motsinger-Reif AA, Dudek SM, Hahn LW, Ritchie MD. Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology. Genetic Epidemiology. 32: 325-40. PMID 18265411 DOI: 10.1002/gepi.20307  0.92
2007 Motsinger AA, Reif DM, Fanelli TJ, Davis AC, Ritchie MD. Linkage Disequilibrium in Genetic Association Studies Improves the Performance of Grammatical Evolution Neural Networks. Proceedings of the ... Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. 2007: 1-8. PMID 21572972  0.76
2007 Bush WS, Thornton-Wells TA, Ritchie MD. Association Rule Discovery Has the Ability to Model Complex Genetic Effects. Ieee Symposium On Computational Intelligence and Data Mining Ieee Symposium On Computational Intelligence and Data Mining. 2007: 624-629. PMID 20953276 DOI: 10.1109/CIDM.2007.368934  0.92
2007 Ritchie MD, Motsinger AA, Bush WS, Coffey CS, Moore JH. Genetic Programming Neural Networks: A Powerful Bioinformatics Tool for Human Genetics. Applied Soft Computing. 7: 471-479. PMID 20948988 DOI: 10.1016/j.asoc.2006.01.013  0.92
2007 Ritchie MD, Bartlett J, Bush WS, Edwards TL, Motsinger AA, Torstenson ES. Exploring epistasis in candidate genes for rheumatoid arthritis. Bmc Proceedings. 1: S70. PMID 18466572  0.76
2007 Bartlett CW, Vieland VJ, Bartlett J, Bell JT, Bhattacharjee S, Clerget-Darpoux F, Bush WS, Edwards TL, Gao G, Halder I, Huang Y, Kotti S, Larkin EK, Li H, Motsinger AA, ... ... Ritchie MD, et al. Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky. Genetic Epidemiology. 31: S61-7. PMID 18046759 DOI: 10.1002/gepi.20281  0.76
2007 Motsinger AA, Ritchie MD, Reif DM. Novel methods for detecting epistasis in pharmacogenomics studies. Pharmacogenomics. 8: 1229-41. PMID 17924838 DOI: 10.2217/14622416.8.9.1229  0.76
2007 Ritchie MD, Edwards TL, Fanelli TJ, Motsinger AA. Genetic heterogeneity is not as threatening as you might think. Genetic Epidemiology. 31: 797-800. PMID 17654613 DOI: 10.1002/gepi.20256  0.92
2007 Ashley-Koch AE, Jaworski J, Ma de Q, Mei H, Ritchie MD, Skaar DA, Robert Delong G, Worley G, Abramson RK, Wright HH, Cuccaro ML, Gilbert JR, Martin ER, Pericak-Vance MA. Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk. Psychiatric Genetics. 17: 221-6. PMID 17621165 DOI: 10.1097/YPG.0b013e32809c2f75  0.92
2007 Williams SM, Canter JA, Crawford DC, Moore JH, Ritchie MD, Haines JL. Problems with genome-wide association studies. Science (New York, N.Y.). 316: 1840-2. PMID 17605173  0.92
2007 Darbar D, Motsinger AA, Ritchie MD, Gainer JV, Roden DM. Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm. 4: 743-9. PMID 17556195 DOI: 10.1016/j.hrthm.2007.02.006  0.52
2007 Motsinger AA, Haas DW, Hulgan T, Ritchie MD. Human genomic association studies: a primer for the infectious diseases specialist. The Journal of Infectious Diseases. 195: 1737-44. PMID 17492588 DOI: 10.1086/518247  0.6
2007 Crawford DC, Ritchie MD, Rieder MJ. Identifying the genotype behind the phenotype: A role model found in VKORC1 and its association with warfarin dosing Pharmacogenomics. 8: 487-496. PMID 17465713 DOI: 10.2217/14622416.8.5.487  0.92
2007 Velez DR, White BC, Motsinger AA, Bush WS, Ritchie MD, Williams SM, Moore JH. A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genetic Epidemiology. 31: 306-15. PMID 17323372 DOI: 10.1002/gepi.20211  0.92
2007 Nordgard SH, Ritchie MD, Jensrud SD, Motsinger AA, Alnaes GI, Lemmon G, Berg M, Geisler S, Moore JH, Lønning PE, Børresen-Dale AL, Kristensen VN. ABCB1 and GST polymorphisms associated with TP53 status in breast cancer. Pharmacogenetics and Genomics. 17: 127-36. PMID 17301692 DOI: 10.1097/FPC.0b013e328011abaa  0.92
2007 Canter JA, Summar ML, Smith HB, Rice GD, Hall LD, Ritchie MD, Motsinger AA, Christian KG, Drinkwater DC, Scholl FG, Dyer KL, Kavanaugh-McHugh AL, Barr FE. Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study. Mitochondrion. 7: 204-10. PMID 17188582 DOI: 10.1016/j.mito.2006.11.001  0.92
2007 Tsai CT, Hwang JJ, Ritchie MD, Moore JH, Chiang FT, Lai LP, Hsu KL, Tseng CD, Lin JL, Tseng YZ. Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis. 195: 172-80. PMID 17118372 DOI: 10.1016/j.atherosclerosis.2006.09.014  0.92
2007 Motsinger AA, Brassat D, Caillier SJ, Erlich HA, Walker K, Steiner LL, Barcellos LF, Pericak-Vance MA, Schmidt S, Gregory S, Hauser SL, Haines JL, Oksenberg JR, Ritchie MD. Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. Neurogenetics. 8: 11-20. PMID 17024427 DOI: 10.1007/s10048-006-0058-9  0.92
2006 Motsinger AA, Reif DM, Dudek SM, Ritchie MD. Understanding the Evolutionary Process of Grammatical Evolution Neural Networks for Feature Selection in Genetic Epidemiology. Proceedings of the ... Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology. 2006: 1-8. PMID 20634919 DOI: 10.1109/CIBCB.2006.330945  0.92
2006 Motsinger AA, Hahn LW, Dudek SM, Ryckman KK, Ritchie MD. Alternative Cross-Over Strategies and Selection Techniques for Grammatical Evolution Optimized Neural Networks. Genetic and Evolutionary Computation Conference : [Proceedings] / Sponsored by Acm Sigevo. Genetic and Evolutionary Computation Conference. 2006: 947-948. PMID 20634918 DOI: 10.1145/1143997.1144163  0.92
2006 Motsinger AA, Donahue BS, Brown NJ, Roden DM, Ritchie MD. Risk factor interactions and genetic effects associated with post-operative atrial fibrillation. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 584-95. PMID 17094271  0.52
2006 Dudek SM, Motsinger AA, Velez DR, Williams SM, Ritchie MD. Data simulation software for whole-genome association and other studies in human genetics. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 499-510. PMID 17094264  0.92
2006 Motsinger AA, Ritchie MD, Shafer RW, Robbins GK, Morse GD, Labbe L, Wilkinson GR, Clifford DB, D'Aquila RT, Johnson VA, Pollard RB, Merigan TC, Hirsch MS, Donahue JP, Kim RB, et al. Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study. Pharmacogenetics and Genomics. 16: 837-45. PMID 17047492 DOI: 10.1097/01.fpc.0000230413.97596.fa  0.92
2006 Haas DW, Geraghty DE, Andersen J, Mar J, Motsinger AA, D'Aquila RT, Unutmaz D, Benson CA, Ritchie MD, Landay A. Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study. The Journal of Infectious Diseases. 194: 1098-107. PMID 16991084 DOI: 10.1086/507313  0.92
2006 Ritchie MD, Haas DW, Motsinger AA, Donahue JP, Erdem H, Raffanti S, Rebeiro P, George AL, Kim RB, Haines JL, Sterling TR. Drug transporter and metabolizing enzyme gene variants and nonnucleoside reverse-transcriptase inhibitor hepatotoxicity. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 43: 779-82. PMID 16912956 DOI: 10.1086/507101  0.92
2006 Kallianpur AR, Hulgan T, Canter JA, Ritchie MD, Haines JL, Robbins GK, Shafer RW, Clifford DB, Haas DW. Hemochromatosis (HFE) gene mutations and peripheral neuropathy during antiretroviral therapy. Aids (London, England). 20: 1503-13. PMID 16847405 DOI: 10.1097/01.aids.0000237366.56864.3c  0.6
2006 Motsinger AA, Ritchie MD, Dobrin SE. Clinical applications of whole-genome association studies: future applications at the bedside. Expert Review of Molecular Diagnostics. 6: 551-65. PMID 16824029 DOI: 10.1586/14737159.6.4.551  0.92
2006 Bush WS, Dudek SM, Ritchie MD. Parallel multifactor dimensionality reduction: a tool for the large-scale analysis of gene-gene interactions. Bioinformatics (Oxford, England). 22: 2173-4. PMID 16809395 DOI: 10.1093/bioinformatics/btl347  0.92
2006 Motsinger AA, Ritchie MD. The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction. Genetic Epidemiology. 30: 546-55. PMID 16800004 DOI: 10.1002/gepi.20166  0.52
2006 McKinney BA, Reif DM, Ritchie MD, Moore JH. Machine learning for detecting gene-gene interactions: a review. Applied Bioinformatics. 5: 77-88. PMID 16722772  0.92
2006 Motsinger AA, Ritchie MD. Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Human Genomics. 2: 318-28. PMID 16595076  0.52
2006 Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe T, Moore JH, Ritchie MD, Williams SM, Pezzullo JC, Sasaki M, Eisner GM, Jose PA, Felder RA. Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clinical Chemistry. 52: 352-60. PMID 16439609 DOI: 10.1373/clinchem.2005.059139  0.92
2006 Motsinger AA, Lee SL, Mellick G, Ritchie MD. GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease. Bmc Bioinformatics. 7: 39. PMID 16436204 DOI: 10.1186/1471-2105-7-39  0.52
2005 Ritchie MD, Motsinger AA. Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies. Pharmacogenomics. 6: 823-34. PMID 16296945 DOI: 10.2217/14622416.6.8.823  0.52
2005 Ritchie MD. Bioinformatics approaches for detecting gene-gene and gene-environment interactions in studies of human disease Neurosurgical Focus. 19. PMID 16241104  0.92
2005 Hulgan T, Haas DW, Haines JL, Ritchie MD, Robbins GK, Shafer RW, Clifford DB, Kallianpur AR, Summar M, Canter JA. Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. Aids (London, England). 19: 1341-9. PMID 16103764  0.6
2005 Wilke RA, Carrillo MW, Ritchie MD. Pacific Symposium on Biocomputing--computational approaches for pharmacogenomics. Pharmacogenomics. 6: 111-3. PMID 15882130 DOI: 10.1517/14622416.6.2.111  0.92
2005 Soares ML, Coelho T, Sousa A, Batalov S, Conceição I, Sales-Luís ML, Ritchie MD, Williams SM, Nievergelt CM, Schork NJ, Saraiva MJ, Buxbaum JN. Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Human Molecular Genetics. 14: 543-53. PMID 15649951 DOI: 10.1093/hmg/ddi051  0.4
2004 Moore JH, Hahn LW, Ritchie MD, Thornton TA, White BC. Routine Discovery of Complex Genetic Models using Genetic Algorithms. Applied Soft Computing. 4: 79-86. PMID 20948983 DOI: 10.1016/j.asoc.2003.08.003  0.92
2004 Vanhoose AM, Ritchie MD, Winder DG. Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice. Neuroscience Letters. 370: 80-3. PMID 15489022 DOI: 10.1016/j.neulet.2004.07.093  0.92
2004 Shin NY, Dise RS, Schneider-Mergener J, Ritchie MD, Kilkenny DM, Hanks SK. Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. The Journal of Biological Chemistry. 279: 38331-7. PMID 15247284 DOI: 10.1074/jbc.M404675200  0.92
2004 Williams SM, Ritchie MD, Phillips JA, Dawson E, Prince M, Dzhura E, Willis A, Semenya A, Summar M, White BC, Addy JH, Kpodonu J, Wong LJ, Felder RA, Jose PA, et al. Multilocus analysis of hypertension: a hierarchical approach. Human Heredity. 57: 28-38. PMID 15133310 DOI: 10.1159/000077387  0.92
2004 Coffey CS, Hebert PR, Ritchie MD, Krumholz HM, Gaziano JM, Ridker PM, Brown NJ, Vaughan DE, Moore JH. An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. Bmc Bioinformatics. 5: 49. PMID 15119966 DOI: 10.1186/1471-2105-5-49  0.92
2004 Moore JH, Ritchie MD. STUDENTJAMA. The challenges of whole-genome approaches to common diseases. Jama. 291: 1642-3. PMID 15069055 DOI: 10.1001/jama.291.13.1642  0.92
2004 Tsai CT, Lai LP, Lin JL, Chiang FT, Hwang JJ, Ritchie MD, Moore JH, Hsu KL, Tseng CD, Liau CS, Tseng YZ. Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation. 109: 1640-6. PMID 15023884 DOI: 10.1161/01.CIR.0000124487.36586.26  0.92
2003 Moore JH, Thornton TA, Ritchie MD. Basic statistics. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Appendix 3M. PMID 18428338 DOI: 10.1002/0471142905.hga03ms37  0.92
2003 Ritchie MD, White BC, Parker JS, Hahn LW, Moore JH. Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases. Bmc Bioinformatics. 4: 28. PMID 12846935 DOI: 10.1186/1471-2105-4-28  0.92
2003 Hahn LW, Ritchie MD, Moore JH. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (Oxford, England). 19: 376-82. PMID 12584123  0.92
2003 Ritchie MD, Hahn LW, Moore JH. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genetic Epidemiology. 24: 150-7. PMID 12548676 DOI: 10.1002/gepi.10218  0.92
2002 Moore JH, Hahn LW, Ritchie MD, Thornton TA, White BC. Application of Genetic Algorithms to the Discovery of Complex Models for Simulation Studies in Human Genetics. Proceedings of the Genetic and Evolutionary Computation Conference / Gecco. Genetic and Evolutionary Computation Conference. 2002: 1150-1155. PMID 23413413  0.92
2002 Donaldson JC, Dise RS, Ritchie MD, Hanks SK. Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. The Journal of Biological Chemistry. 277: 29028-35. PMID 12006559 DOI: 10.1074/jbc.M111697200  0.92
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