Kevin D. Costa, Ph.D. - Publications

Bioengineering University of California, San Diego, La Jolla, CA 
cardiac biomechanics, tissue engineering, atomic force microscopy

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lee JJ, Rao S, Kaushik G, Azeloglu EU, Costa KD. Dehomogenized Elastic Properties of Heterogeneous Layered Materials in AFM Indentation Experiments. Biophysical Journal. 114: 2717-2731. PMID 29874620 DOI: 10.1016/j.bpj.2018.04.036  0.96
2017 Zhou N, Lee JJ, Stoll S, Ma B, Costa KD, Qiu H. Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 44: 701-715. PMID 29169155 DOI: 10.1159/000485284  0.32
2016 Zhou N, Lee JJ, Stoll S, Ma B, Wiener R, Wang C, Costa KD, Qiu H. Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension. Cardiovascular Research. PMID 28003268 DOI: 10.1093/cvr/cvw222  0.32
2016 Lee JJ, Galatioto J, Rao S, Ramirez F, Costa KD. Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome. Annals of Biomedical Engineering. PMID 27090893 DOI: 10.1007/s10439-016-1616-4  0.92
2016 Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, Casaccia P. Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 806-13. PMID 26791211 DOI: 10.1523/JNEUROSCI.2873-15.2016  0.92
2015 Kerscher P, Turnbull IC, Hodge AJ, Kim J, Seliktar D, Easley CJ, Costa KD, Lipke EA. Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues. Biomaterials. 83: 383-395. PMID 26826618 DOI: 10.1016/j.biomaterials.2015.12.011  0.48
2015 Turnbull IC, Eltoukhy AA, Fish KM, Nonnenmacher M, Ishikawa K, Chen J, Hajjar RJ, Anderson DG, Costa KD. Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26471463 DOI: 10.1038/mt.2015.193  0.92
2015 Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA. Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs. Circulation. Arrhythmia and Electrophysiology. 8: 193-202. PMID 25504561 DOI: 10.1161/CIRCEP.114.002049  0.92
2015 Ishikawa K, Fish K, Aguero J, Yaniz-Galende E, Jeong D, Kho C, Tilemann L, Fish L, Liang L, Eltoukhy AA, Anderson DG, Zsebo K, Costa KD, Hajjar RJ. Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine. Circulation. Heart Failure. 8: 167-74. PMID 25342737 DOI: 10.1161/CIRCHEARTFAILURE.114.001711  0.92
2014 Cook JR, Carta L, Bénard L, Chemaly ER, Chiu E, Rao SK, Hampton TG, Yurchenco P, Costa KD, Hajjar RJ, Ramirez F. Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. The Journal of Clinical Investigation. 124: 1329-39. PMID 24531548 DOI: 10.1172/JCI71059  0.92
2014 Turnbull IC, Karakikes I, Serrao GW, Backeris P, Lee JJ, Xie C, Senyei G, Gordon RE, Li RA, Akar FG, Hajjar RJ, Hulot JS, Costa KD. Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 644-54. PMID 24174427 DOI: 10.1096/fj.13-228007  0.92
2013 Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 34: 8878-86. PMID 23942210 DOI: 10.1016/j.biomaterials.2013.07.039  0.92
2013 Gianella A, Mieszawska AJ, Hoeben FJM, Janssen HM, Jarzyna PA, Cormode DP, Costa KD, Rao S, Farokhzad OC, Langer R, Fayad ZA, Mulder WJM. Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform Chemical Communications. 49: 9392-9394. PMID 23877789 DOI: 10.1039/c3cc43618g  0.92
2011 Costa KD, Kleinstein SH, Hershberg U. Biomedical model fitting and error analysis. Science Signaling. 4: tr9. PMID 21954296 DOI: 10.1126/scisignal.2001983  0.92
2011 Wang X, Chen S, Kong M, Wang Z, Costa KD, Li RA, Sun D. Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies. Lab On a Chip. 11: 3656-62. PMID 21918752 DOI: 10.1039/c1lc20653b  0.92
2011 Azeloglu EU, Costa KD. Atomic force microscopy in mechanobiology: measuring microelastic heterogeneity of living cells. Methods in Molecular Biology (Clifton, N.J.). 736: 303-29. PMID 21660735 DOI: 10.1007/978-1-61779-105-5_19  0.96
2010 Huo B, Lu XL, Costa KD, Xu Q, Guo XE. An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation. Cell Calcium. 47: 234-41. PMID 20060586 DOI: 10.1016/j.ceca.2009.12.005  0.92
2010 Azeloglu EU, Costa KD. Cross-bridge cycling gives rise to spatiotemporal heterogeneity of dynamic subcellular mechanics in cardiac myocytes probed with atomic force microscopy. American Journal of Physiology. Heart and Circulatory Physiology. 298: H853-60. PMID 20023124 DOI: 10.1152/ajpheart.00427.2009  0.96
2009 Azeloglu EU, Costa KD. Dynamic AFM elastography reveals phase dependent mechanical heterogeneity of beating cardiac myocytes. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 7180-3. PMID 19965272 DOI: 10.1109/IEMBS.2009.5335316  0.96
2009 Azeloglu EU, Kaushik G, Costa KD. Developing a hybrid computational model of AFM indentation for analysis of mechanically heterogeneous samples. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 4273-6. PMID 19964629 DOI: 10.1109/IEMBS.2009.5334043  0.96
2009 Ateshian GA, Costa KD, Azeloglu EU, Morrison B, Hung CT. Continuum modeling of biological tissue growth by cell division, and alteration of intracellular osmolytes and extracellular fixed charge density. Journal of Biomechanical Engineering. 131: 101001. PMID 19831471 DOI: 10.1115/1.3192138  0.96
2009 Cheung YK, Azeloglu EU, Shiovitz DA, Costa KD, Seliktar D, Sia SK. Microscale control of stiffness in a cell-adhesive substrate using microfluidics-based lithography. Angewandte Chemie (International Ed. in English). 48: 7188-92. PMID 19479917 DOI: 10.1002/anie.200900807  0.92
2009 Ateshian GA, Costa KD. A frame-invariant formulation of Fung elasticity. Journal of Biomechanics. 42: 781-5. PMID 19281991 DOI: 10.1016/j.jbiomech.2009.01.015  0.92
2009 Duan Q, Angelini ED, Herz SL, Ingrassia CM, Costa KD, Holmes JW, Homma S, Laine AF. Region-based endocardium tracking on real-time three-dimensional ultrasound. Ultrasound in Medicine & Biology. 35: 256-65. PMID 18963396 DOI: 10.1016/j.ultrasmedbio.2008.08.012  0.92
2008 Huo B, Lu XL, Hung CT, Costa KD, Xu Q, Whitesides GM, Guo XE. Fluid Flow Induced Calcium Response in Bone Cell Network. Cellular and Molecular Bioengineering. 1: 58-66. PMID 20852730 DOI: 10.1007/s12195-008-0011-0  0.32
2008 Azeloglu EU, Bhattacharya J, Costa KD. Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness. Journal of Applied Physiology (Bethesda, Md. : 1985). 105: 652-61. PMID 18535125 DOI: 10.1152/japplphysiol.00958.2007  0.96
2008 Lee EJ, Holmes JW, Costa KD. Remodeling of engineered tissue anisotropy in response to altered loading conditions. Annals of Biomedical Engineering. 36: 1322-34. PMID 18470621 DOI: 10.1007/s10439-008-9509-9  0.96
2008 Lee EJ, Kim DE, Azeloglu EU, Costa KD. Engineered cardiac organoid chambers: toward a functional biological model ventricle. Tissue Engineering. Part A. 14: 215-25. PMID 18333774 DOI: 10.1089/tea.2007.0351  0.96
2008 Azeloglu EU, Albro MB, Thimmappa VA, Ateshian GA, Costa KD. Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta. American Journal of Physiology. Heart and Circulatory Physiology. 294: H1197-205. PMID 18156194 DOI: 10.1152/ajpheart.01027.2007  0.92
2007 Lee WN, Ingrassia CM, Fung-Kee-Fung SD, Costa KD, Holmes JW, Konofagou EE. Theoretical quality assessment of myocardial elastography with in vivo validation. Ieee Transactions On Ultrasonics, Ferroelectrics, and Frequency Control. 54: 2233-45. PMID 18051158 DOI: 10.1109/TUFFC.2007.528  0.92
2007 Elkin BS, Azeloglu EU, Costa KD, Morrison B. Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation. Journal of Neurotrauma. 24: 812-22. PMID 17518536 DOI: 10.1089/neu.2006.0169  0.92
2006 Holmes JW, Costa KD. Imaging cardiac mechanics: what information do we need to extract from cardiac images? Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 1545-7. PMID 17946901 DOI: 10.1109/IEMBS.2006.259642  0.96
2006 Kim do E, Lee EJ, Martens TP, Kara R, Chaudhry HW, Itescu S, Costa KD. Engineered cardiac tissues for in vitro assessment of contractile function and repair mechanisms. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 849-52. PMID 17946863 DOI: 10.1109/IEMBS.2006.259753  0.92
2006 Herz SL, Ingrassia CM, Costa KD, Holmes JW. Model-based screening of wall motion measures for detection of ischemia in three-dimensional cardiac images. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 628-31. PMID 17946412 DOI: 10.1109/IEMBS.2006.260387  0.92
2006 Guo XE, Takai E, Jiang X, Xu Q, Whitesides GM, Yardley JT, Hung CT, Chow EM, Hantschel T, Costa KD. Intracellular calcium waves in bone cell networks under single cell nanoindentation. Molecular & Cellular Biomechanics : McB. 3: 95-107. PMID 17263256  0.92
2006 Costa KD, Sim AJ, Yin FC. Non-Hertzian approach to analyzing mechanical properties of endothelial cells probed by atomic force microscopy. Journal of Biomechanical Engineering. 128: 176-84. PMID 16524328 DOI: 10.1115/1.2165690  0.64
2005 Takai E, Costa KD, Shaheen A, Hung CT, Guo XE. Osteoblast elastic modulus measured by atomic force microscopy is substrate dependent. Annals of Biomedical Engineering. 33: 963-71. PMID 16060537 DOI: 10.1007/s10439-005-3555-3  0.92
2005 Herz SL, Ingrassia CM, Homma S, Costa KD, Holmes JW. Parameterization of left ventricular wall motion for detection of regional ischemia. Annals of Biomedical Engineering. 33: 912-9. PMID 16060531 DOI: 10.1007/s10439-005-3312-7  0.92
2005 Chao PG, Tang Z, Angelini E, West AC, Costa KD, Hung CT. Dynamic osmotic loading of chondrocytes using a novel microfluidic device. Journal of Biomechanics. 38: 1273-81. PMID 15863112 DOI: 10.1016/j.jbiomech.2004.06.016  0.92
2005 Ng KW, Wang CC, Mauck RL, Kelly TA, Chahine NO, Costa KD, Ateshian GA, Hung CT. A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 23: 134-41. PMID 15607885 DOI: 10.1016/j.orthres.2004.05.015  0.92
2004 Park S, Costa KD, Ateshian GA. Microscale frictional response of bovine articular cartilage from atomic force microscopy. Journal of Biomechanics. 37: 1679-87. PMID 15388310 DOI: 10.1016/j.jbiomech.2004.02.017  0.92
2003 Costa KD, Lee EJ, Holmes JW. Creating alignment and anisotropy in engineered heart tissue: role of boundary conditions in a model three-dimensional culture system. Tissue Engineering. 9: 567-77. PMID 13678436 DOI: 10.1089/107632703768247278  0.96
2002 Costa KD, Hucker WJ, Yin FC. Buckling of actin stress fibers: a new wrinkle in the cytoskeletal tapestry. Cell Motility and the Cytoskeleton. 52: 266-74. PMID 12112140 DOI: 10.1002/cm.10056  0.92
2002 Takayama Y, Costa KD, Covell JW. Contribution of laminar myofiber architecture to load-dependent changes in mechanics of LV myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 282: H1510-20. PMID 11893589 DOI: 10.1152/ajpheart.00261.2001  0.92
1997 Costa KD, May-Newman K, Farr D, O'Dell WG, McCulloch AD, Omens JH. Three-dimensional residual strain in midanterior canine left ventricle. American Journal of Physiology. Heart and Circulatory Physiology. 273: H1968-H1976. PMID 29586327 DOI: 10.1152/ajpheart.1997.273.4.H1968  0.56
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