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Brandt Eichman, Ph.D. - Publications

Affiliations: 
Biochemistry Vanderbilt University, Nashville, TN 
Area:
DNA replication
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75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Rua-Fernandez J, Lovejoy CA, Mehta KPM, Paulin KA, Toudji YT, Giansanti C, Eichman BF, Cortez D. Self-reversal facilitates the resolution of HMCES DNA-protein crosslinks in cells. Cell Reports. 42: 113427. PMID 37950866 DOI: 10.1016/j.celrep.2023.113427  0.488
2023 Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ. Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase. Journal of Molecular Biology. 168330. PMID 37884206 DOI: 10.1016/j.jmb.2023.168330  0.333
2023 Cordoba JJ, Mullins EA, Salay LE, Eichman BF, Chazin WJ. Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase. Biorxiv : the Preprint Server For Biology. PMID 37577606 DOI: 10.1101/2023.08.01.551538  0.332
2023 Rua-Fernandez J, Lovejoy CA, Mehta KPM, Paulin KA, Toudji YT, Eichman BF, Cortez D. Self-reversal facilitates the resolution of HMCES-DNA protein crosslinks in cells. Biorxiv : the Preprint Server For Biology. PMID 37398432 DOI: 10.1101/2023.06.14.544844  0.492
2023 Eichman BF. Repair and tolerance of DNA damage at the replication fork: A structural perspective. Current Opinion in Structural Biology. 81: 102618. PMID 37269798 DOI: 10.1016/j.sbi.2023.102618  0.409
2023 Ngo K, Gittens TH, Gonzalez DI, Hatmaker EA, Plotkin S, Engle M, Friedman GA, Goldin M, Hoerr RE, Eichman BF, Rokas A, Benton ML, Friedman KL. A comprehensive map of hotspots of de novo telomere addition in Saccharomyces cerevisiae. Genetics. PMID 37119805 DOI: 10.1093/genetics/iyad076  0.335
2023 Mullins EA, Salay LE, Durie CL, Jackman JE, Ohi MD, Chazin WJ, Eichman BF. A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α-primase. Biorxiv : the Preprint Server For Biology. PMID 36993335 DOI: 10.1101/2023.03.16.533013  0.518
2023 Ngo K, Gittens TH, Gonzalez DI, Hatmaker EA, Plotkin S, Engle M, Friedman GA, Goldin M, Hoerr RE, Eichman BF, Rokas A, Benton ML, Friedman KL. A comprehensive map of hotspots of de novo telomere addition in . Biorxiv : the Preprint Server For Biology. PMID 36993206 DOI: 10.1101/2023.03.20.533556  0.335
2023 Dorival J, Eichman BF. Human and bacterial TatD enzymes exhibit apurinic/apyrimidinic (AP) endonuclease activity. Nucleic Acids Research. 51: 2838-2849. PMID 36881763 DOI: 10.1093/nar/gkad133  0.32
2023 Campos LV, Van Ravenstein SX, Vontalge EJ, Greer BH, Heintzman DR, Kavlashvili T, McDonald WH, Rose KL, Eichman BF, Dewar JM. RTEL1 and MCM10 overcome topological stress during vertebrate replication termination. Cell Reports. 42: 112109. PMID 36807139 DOI: 10.1016/j.celrep.2023.112109  0.345
2022 Paulin KA, Cortez D, Eichman BF. The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA-protein crosslink. The Journal of Biological Chemistry. 102307. PMID 35934051 DOI: 10.1016/j.jbc.2022.102307  0.526
2022 Bradley NP, Wahl KL, Steenwyk JL, Rokas A, Eichman BF. Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases. Mbio. e0329721. PMID 35311535 DOI: 10.1128/mbio.03297-21  0.44
2022 Chen X, Bradley NP, Lu W, Wahl KL, Zhang M, Yuan H, Hou XF, Eichman BF, Tang GL. Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance. Nucleic Acids Research. PMID 35191495 DOI: 10.1093/nar/gkac085  0.545
2021 Mullins EA, Dorival J, Tang GL, Boger DL, Eichman BF. Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites. Nature Communications. 12: 6942. PMID 34836957 DOI: 10.1038/s41467-021-27284-7  0.306
2020 Rodriguez AA, Wojtaszek JL, Greer BH, Haldar T, Gates KS, Williams RS, Eichman BF. An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3. The Journal of Biological Chemistry. PMID 32878989 DOI: 10.1074/Jbc.Ra120.015541  0.582
2020 Amidon KM, Eichman BF. Structural biology of DNA abasic site protection by SRAP proteins. Dna Repair. 94: 102903. PMID 32663791 DOI: 10.1016/j.dnarep.2020.102903  0.541
2020 Bai G, Kermi C, Stoy H, Schiltz CJ, Bacal J, Zaino AM, Hadden MK, Eichman BF, Lopes M, Cimprich KA. HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis. Molecular Cell. PMID 32442397 DOI: 10.1016/J.Molcel.2020.04.031  0.355
2020 Bradley NP, Washburn LA, Christov PP, Watanabe CMH, Eichman BF. Escherichia coli YcaQ is a DNA glycosylase that unhooks DNA interstrand crosslinks. Nucleic Acids Research. PMID 32409837 DOI: 10.1093/Nar/Gkaa346  0.517
2020 Imani Nejad M, Housh K, Rodriguez AA, Haldar T, Kathe S, Wallace SS, Eichman BF, Gates KS. Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3. Dna Repair. 86: 102752. PMID 31923807 DOI: 10.1016/J.Dnarep.2019.102752  0.536
2019 Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK. The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10. Open Biology. 9: 190117. PMID 31409229 DOI: 10.1098/Rsob.190117  0.384
2019 Thompson PS, Amidon KM, Mohni KN, Cortez D, Eichman BF. Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link. Nature Structural & Molecular Biology. PMID 31235915 DOI: 10.1107/S0108767319097988  0.472
2019 Steenwyk JL, Opulente DA, Kominek J, Shen XX, Zhou X, Labella AL, Bradley NP, Eichman BF, Čadež N, Libkind D, DeVirgilio J, Hulfachor AB, Kurtzman CP, Hittinger CT, Rokas A. Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts. Plos Biology. 17: e3000255. PMID 31112549 DOI: 10.1371/Journal.Pbio.3000255  0.383
2019 Mullins EA, Rodriguez AA, Bradley NP, Eichman BF. Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway. Trends in Biochemical Sciences. PMID 31078398 DOI: 10.1016/J.Tibs.2019.04.006  0.426
2018 Mohni KN, Wessel SR, Zhao R, Wojciechowski AC, Luzwick JW, Layden H, Eichman BF, Thompson PS, Mehta KPM, Cortez D. HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA. Cell. PMID 30554877 DOI: 10.1016/J.Cell.2018.10.055  0.539
2018 Warren GM, Stein RA, Mchaourab HS, Eichman BF. Movement of the RecG Motor Domain upon DNA Binding Is Required for Efficient Fork Reversal. International Journal of Molecular Sciences. 19. PMID 30301235 DOI: 10.3390/Ijms19103049  0.573
2018 Shi R, Shen XX, Rokas A, Eichman BF. Structural Biology of the HEAT-Like Repeat Family of DNA Glycosylases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 30264543 DOI: 10.1002/Bies.201800133  0.547
2018 Chavez DA, Greer BH, Eichman BF. The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression. The Journal of Biological Chemistry. PMID 29643183 DOI: 10.1074/jbc.RA118.002905  0.533
2017 Shi R, Mullins EA, Shen XX, Lay KT, Yuen PK, David SS, Rokas A, Eichman BF. Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC. The Embo Journal. PMID 29054852 DOI: 10.15252/Embj.201797833  0.5
2017 Mullins EA, Shi R, Eichman BF. Toxicity and repair of DNA adducts produced by the natural product yatakemycin. Nature Chemical Biology. PMID 28759018 DOI: 10.1038/Nchembio.2439  0.458
2017 Mullins EA, Warren GM, Bradley NP, Eichman BF. Structure of a DNA glycosylase that unhooks interstrand cross-links. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396405 DOI: 10.1073/Pnas.1703066114  0.581
2016 Parsons ZD, Bland JM, Mullins EA, Eichman BF. A Catalytic Role for C-H/π Interactions in Base Excision Repair by Bacillus cereus DNA Glycosylase AlkD. Journal of the American Chemical Society. PMID 27571247 DOI: 10.1021/Jacs.6B07399  0.45
2016 Badu-Nkansah A, Mason AC, Eichman BF, Cortez D. Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain Containing Protein 3 (ZRANB3). The Journal of Biological Chemistry. PMID 26884333 DOI: 10.1074/Jbc.M115.709733  0.488
2015 Mullins EA, Shi R, Parsons ZD, Yuen PK, David SS, Igarashi Y, Eichman BF. The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions. Nature. PMID 26524531 DOI: 10.1038/Nature15728  0.541
2015 Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA. HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal. Molecular Cell. 58: 1090-100. PMID 26051180 DOI: 10.1016/J.Molcel.2015.05.013  0.532
2015 Mullins EA, Shi R, Kotsch LA, Eichman BF. A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases. Plos One. 10: e0127733. PMID 25978435 DOI: 10.1371/Journal.Pone.0127733  0.581
2015 Szulik MW, Pallan PS, Nocek B, Voehler M, Banerjee S, Brooks S, Joachimiak A, Egli M, Eichman BF, Stone MP. Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine. Biochemistry. 54: 1294-305. PMID 25632825 DOI: 10.1021/Bi501534X  0.38
2014 Mason AC, Rambo RP, Greer B, Pritchett M, Tainer JA, Cortez D, Eichman BF. A structure-specific nucleic acid-binding domain conserved among DNA repair proteins. Proceedings of the National Academy of Sciences of the United States of America. 111: 7618-23. PMID 24821763 DOI: 10.1073/Pnas.1324143111  0.536
2014 Feldkamp MD, Mason AC, Eichman BF, Chazin WJ. Structural analysis of replication protein A recruitment of the DNA damage response protein SMARCAL1. Biochemistry. 53: 3052-61. PMID 24730652 DOI: 10.1021/Bi500252W  0.531
2014 Troll CJ, Adhikary S, Cueff M, Mitra I, Eichman BF, Camps M. Interplay between base excision repair activity and toxicity of 3-methyladenine DNA glycosylases in an E. coli complementation system. Mutation Research. 763: 64-73. PMID 24709477 DOI: 10.1016/J.Mrfmmm.2014.03.007  0.348
2014 Brooks SC, Fischer RL, Huh JH, Eichman BF. 5-methylcytosine recognition by Arabidopsis thaliana DNA glycosylases DEMETER and DML3. Biochemistry. 53: 2525-32. PMID 24678721 DOI: 10.1021/Bi5002294  0.493
2014 Jang H, Shin H, Eichman BF, Huh JH. Excision of 5-hydroxymethylcytosine by DEMETER family DNA glycosylases. Biochemical and Biophysical Research Communications. 446: 1067-72. PMID 24661881 DOI: 10.1016/j.bbrc.2014.03.060  0.391
2014 Mullins EA, Rubinson EH, Eichman BF. The substrate binding interface of alkylpurine DNA glycosylase AlkD. Dna Repair. 13: 50-4. PMID 24286669 DOI: 10.1016/J.Dnarep.2013.10.009  0.551
2014 Vaithiyalingam S, Arnett DR, Aggarwal A, Eichman BF, Fanning E, Chazin WJ. Insights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase. Journal of Molecular Biology. 426: 558-69. PMID 24239947 DOI: 10.1016/J.Jmb.2013.11.007  0.47
2013 Rubinson EH, Christov PP, Eichman BF. Depurination of N7-methylguanine by DNA glycosylase AlkD is dependent on the DNA backbone. Biochemistry. 52: 7363-5. PMID 24090276 DOI: 10.1021/Bi401195R  0.502
2013 Du W, Josephrajan A, Adhikary S, Bowles T, Bielinsky AK, Eichman BF. Mcm10 self-association is mediated by an N-terminal coiled-coil domain. Plos One. 8: e70518. PMID 23894664 DOI: 10.1371/Journal.Pone.0070518  0.596
2013 Mullins EA, Rubinson EH, Pereira KN, Calcutt MW, Christov PP, Eichman BF. An HPLC-tandem mass spectrometry method for simultaneous detection of alkylated base excision repair products. Methods (San Diego, Calif.). 64: 59-66. PMID 23876937 DOI: 10.1016/J.Ymeth.2013.07.020  0.429
2013 Bétous R, Couch FB, Mason AC, Eichman BF, Manosas M, Cortez D. Substrate-selective repair and restart of replication forks by DNA translocases. Cell Reports. 3: 1958-69. PMID 23746452 DOI: 10.1016/J.Celrep.2013.05.002  0.493
2013 Adhikary S, Cato MC, McGary KL, Rokas A, Eichman BF. Non-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombe. Dna Repair. 12: 196-204. PMID 23273506 DOI: 10.1016/J.Dnarep.2012.12.001  0.6
2013 Brooks SC, Adhikary S, Rubinson EH, Eichman BF. Recent advances in the structural mechanisms of DNA glycosylases. Biochimica Et Biophysica Acta. 1834: 247-71. PMID 23076011 DOI: 10.1016/j.bbapap.2012.10.005  0.515
2012 Du W, Stauffer ME, Eichman BF. Structural biology of replication initiation factor Mcm10. Sub-Cellular Biochemistry. 62: 197-216. PMID 22918587 DOI: 10.1007/978-94-007-4572-8_11  0.652
2012 Bétous R, Mason AC, Rambo RP, Bansbach CE, Badu-Nkansah A, Sirbu BM, Eichman BF, Cortez D. SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication. Genes & Development. 26: 151-62. PMID 22279047 DOI: 10.1101/Gad.178459.111  0.521
2012 Rubinson EH, Eichman BF. Nucleic acid recognition by tandem helical repeats. Current Opinion in Structural Biology. 22: 101-9. PMID 22154606 DOI: 10.1016/j.sbi.2011.11.005  0.545
2011 Camps M, Eichman BF. Unraveling a connection between DNA demethylation repair and cancer. Molecular Cell. 44: 343-4. PMID 22055180 DOI: 10.1016/J.Molcel.2011.10.009  0.328
2011 Adhikary S, Eichman BF. Analysis of substrate specificity of Schizosaccharomyces pombe Mag1 alkylpurine DNA glycosylase. Embo Reports. 12: 1286-92. PMID 21960007 DOI: 10.1038/embor.2011.189  0.56
2010 Mok YG, Uzawa R, Lee J, Weiner GM, Eichman BF, Fischer RL, Huh JH. Domain structure of the DEMETER 5-methylcytosine DNA glycosylase. Proceedings of the National Academy of Sciences of the United States of America. 107: 19225-30. PMID 20974931 DOI: 10.1073/Pnas.1014348107  0.554
2010 Rubinson EH, Gowda AS, Spratt TE, Gold B, Eichman BF. An unprecedented nucleic acid capture mechanism for excision of DNA damage. Nature. 468: 406-11. PMID 20927102 DOI: 10.1038/nature09428  0.549
2010 Vaithiyalingam S, Warren EM, Eichman BF, Chazin WJ. Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase. Proceedings of the National Academy of Sciences of the United States of America. 107: 13684-9. PMID 20643958 DOI: 10.1073/Pnas.1002009107  0.811
2010 Robertson PD, Chagot B, Chazin WJ, Eichman BF. Solution NMR structure of the C-terminal DNA binding domain of Mcm10 reveals a conserved MCM motif. The Journal of Biological Chemistry. 285: 22942-9. PMID 20489205 DOI: 10.1074/Jbc.M110.131276  0.787
2010 Rubinson EH, Adhikary S, Eichman BF. Structural studies of alkylpurine DNA glycosylases Acs Symposium Series. 1041: 29-45. DOI: 10.1021/bk-2010-1041.ch003  0.583
2009 Warren EM, Huang H, Fanning E, Chazin WJ, Eichman BF. Physical interactions between Mcm10, DNA, and DNA polymerase alpha. The Journal of Biological Chemistry. 284: 24662-72. PMID 19608746 DOI: 10.1074/Jbc.M109.020438  0.786
2008 Warren EM, Vaithiyalingam S, Haworth J, Greer B, Bielinsky AK, Chazin WJ, Eichman BF. Structural basis for DNA binding by replication initiator Mcm10. Structure (London, England : 1993). 16: 1892-901. PMID 19081065 DOI: 10.1016/J.Str.2008.10.005  0.817
2008 Bowles T, Metz AH, O'Quin J, Wawrzak Z, Eichman BF. Structure and DNA binding of alkylation response protein AidB. Proceedings of the National Academy of Sciences of the United States of America. 105: 15299-304. PMID 18829440 DOI: 10.1073/pnas.0806521105  0.595
2008 Rubinson EH, Metz AH, O'Quin J, Eichman BF. A new protein architecture for processing alkylation damaged DNA: the crystal structure of DNA glycosylase AlkD. Journal of Molecular Biology. 381: 13-23. PMID 18585735 DOI: 10.1016/j.jmb.2008.05.078  0.61
2008 Robertson PD, Warren EM, Zhang H, Friedman DB, Lary JW, Cole JL, Tutter AV, Walter JC, Fanning E, Eichman BF. Domain architecture and biochemical characterization of vertebrate Mcm10. The Journal of Biological Chemistry. 283: 3338-48. PMID 18065420 DOI: 10.1074/Jbc.M706267200  0.783
2007 Metz AH, Hollis T, Eichman BF. DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG). The Embo Journal. 26: 2411-20. PMID 17410210 DOI: 10.1038/Sj.Emboj.7601649  0.605
2004 Eichman BF, Fanning E. The power of pumping together; deconstructing the engine of a DNA replication machine. Cell. 119: 3-4. PMID 15454074 DOI: 10.1016/J.Cell.2004.09.023  0.463
2004 Brieba LG, Eichman BF, Kokoska RJ, Doublié S, Kunkel TA, Ellenberger T. Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. The Embo Journal. 23: 3452-61. PMID 15297882 DOI: 10.1038/Sj.Emboj.7600354  0.563
2003 Eichman BF, O'Rourke EJ, Radicella JP, Ellenberger T. Crystal structures of 3-methyladenine DNA glycosylase MagIII and the recognition of alkylated bases. The Embo Journal. 22: 4898-909. PMID 14517230 DOI: 10.1093/Emboj/Cdg505  0.593
2002 Eichman BF, Ortiz-Lombardía M, Aymamí J, Coll M, Ho PS. The inherent properties of DNA four-way junctions: comparing the crystal structures of holliday junctions. Journal of Molecular Biology. 320: 1037-51. PMID 12126623 DOI: 10.1016/S0022-2836(02)00540-5  0.764
2001 Ho PS, Eichman BF. The crystal structures of DNA Holliday junctions. Current Opinion in Structural Biology. 11: 302-8. PMID 11406378 DOI: 10.1016/S0959-440X(00)00219-0  0.688
2001 Eichman BF, Mooers BH, Alberti M, Hearst JE, Ho PS. The crystal structures of psoralen cross-linked DNAs: drug-dependent formation of Holliday junctions. Journal of Molecular Biology. 308: 15-26. PMID 11302703 DOI: 10.1006/Jmbi.2001.4567  0.804
2000 Vargason JM, Eichman BF, Ho PS. The extended and eccentric E-DNA structure induced by cytosine methylation or bromination. Nature Structural Biology. 7: 758-61. PMID 10966645 DOI: 10.1038/78985  0.791
2000 Eichman BF, Vargason JM, Mooers BH, Ho PS. The Holliday junction in an inverted repeat DNA sequence: sequence effects on the structure of four-way junctions. Proceedings of the National Academy of Sciences of the United States of America. 97: 3971-6. PMID 10760268 DOI: 10.1073/Pnas.97.8.3971  0.746
1999 Eichman BF, Schroth GP, Basham BE, Ho PS. The intrinsic structure and stability of out-of-alternation base pairs in Z-DNA. Nucleic Acids Research. 27: 543-50. PMID 9862978 DOI: 10.1093/Nar/27.2.543  0.752
1997 Mooers BH, Eichman BF, Ho PS. The structures and relative stabilities of d(G x G) reverse Hoogsteen, d(G x T) reverse wobble, and d(G x C) reverse Watson-Crick base-pairs in DNA crystals. Journal of Molecular Biology. 269: 796-810. PMID 9223642 DOI: 10.1006/jmbi.1997.1100  0.747
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