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Youxing Jiang - Publications

Affiliations: 
Physiology University of Texas Southwestern Medical Center, Dallas, TX, United States 
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77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Gan N, Zeng W, Han Y, Chen Q, Jiang Y. Structural mechanism of proton conduction in otopetrin proton channel. Nature Communications. 15: 7250. PMID 39179582 DOI: 10.1038/s41467-024-51803-x  0.519
2024 Gan N, Han Y, Zeng W, Jiang Y. TRPML1 gating modulation by allosteric mutations and lipids (Design of allosteric mutations that recapitulate the gating of TRPML1 ). Biorxiv : the Preprint Server For Biology. PMID 39005349 DOI: 10.1101/2024.07.04.602033  0.412
2023 Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y. Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1. Nature Communications. 14: 6181. PMID 37794011 DOI: 10.1038/s41467-023-41885-4  0.347
2022 She J, Guo J, Jiang Y. Structure and Function of Plant and Mammalian TPC Channels. Handbook of Experimental Pharmacology. PMID 35879575 DOI: 10.1007/164_2022_599  0.857
2022 Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y. Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P and rapamycin. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35131932 DOI: 10.1073/pnas.2120404119  0.514
2021 Gan N, Jiang Y. Structural biology of cation channels important for lysosomal calcium release. Cell Calcium. 101: 102519. PMID 34952412 DOI: 10.1016/j.ceca.2021.102519  0.461
2021 Ye F, Xu L, Li X, Zeng W, Gan N, Zhao C, Yang W, Jiang Y, Guo J. Voltage-gating and cytosolic Ca activation mechanisms of two-pore channel AtTPC1. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34845029 DOI: 10.1073/pnas.2113946118  0.76
2021 Xue J, Han Y, Zeng W, Jiang Y. Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron. PMID 34699778 DOI: 10.1016/j.neuron.2021.10.006  0.529
2021 Xue J, Han Y, Baniasadi H, Zeng W, Pei J, Grishin NV, Wang J, Tu BP, Jiang Y. TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase. Elife. 10. PMID 34374645 DOI: 10.7554/eLife.71220  0.404
2021 Xue J, Han Y, Zeng W, Wang Y, Jiang Y. Structural mechanisms of gating and selectivity of human rod CNGA1 channel. Neuron. PMID 33651975 DOI: 10.1016/j.neuron.2021.02.007  0.613
2020 Wang Y, Han Y, She J, Nguyen NX, Mootha VK, Bai XC, Jiang Y. Structural insights into the Ca-dependent gating of the human mitochondrial calcium uniporter. Elife. 9. PMID 32762847 DOI: 10.7554/Elife.60513  0.818
2020 Xue J, Xie T, Zeng W, Jiang Y, Bai XC. Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations. Elife. 9. PMID 32723473 DOI: 10.7554/Elife.58823  0.383
2020 Wang Y, Han Y, She J, Nguyen NX, Mootha VK, Bai X, Jiang Y. Author response: Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter Elife. DOI: 10.7554/Elife.60513.Sa2  0.787
2020 Xue J, Xie T, Zeng W, Jiang Y, Bai X. Author response: Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations Elife. DOI: 10.7554/Elife.58823.Sa2  0.319
2020 Csanády L, Jiang Y, Pless SA. Decision letter: The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity Elife. DOI: 10.7554/Elife.56527.Sa1  0.492
2020 Galione A, Ren D, Jiang Y. Decision letter: Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function Elife. DOI: 10.7554/Elife.54712.Sa1  0.304
2019 Kim S, Zeng W, Bernard S, Liao J, Venkateshwaran M, Ane JM, Jiang Y. Publisher Correction: Ca-regulated Ca channels with an RCK gating ring control plant symbiotic associations. Nature Communications. 10: 4607. PMID 31591395 DOI: 10.1038/S41467-019-12590-Y  0.613
2019 Kim S, Zeng W, Bernard S, Liao J, Venkateshwaran M, Ane JM, Jiang Y. Ca-regulated Ca channels with an RCK gating ring control plant symbiotic associations. Nature Communications. 10: 3703. PMID 31420535 DOI: 10.1038/S41467-019-11698-5  0.704
2019 Wang Y, Nguyen NX, She J, Zeng W, Yang Y, Bai XC, Jiang Y. Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter. Cell. PMID 31080062 DOI: 10.1016/J.Cell.2019.03.050  0.82
2019 Chen Q, Zeng W, She J, Bai X, Jiang Y. Structural and functional characterization of an otopetrin family proton channel. Elife. 8. PMID 30973323 DOI: 10.7554/Elife.46710  0.825
2019 She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y. Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife. 8. PMID 30860481 DOI: 10.2210/Pdb6Nq2/Pdb  0.856
2019 Toombes G, Jiang Y, Sigworth F. Decision letter: Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology Elife. DOI: 10.7554/Elife.52164.Sa1  0.484
2019 Gaudet R, Jiang Y. Decision letter: Structure-based characterization of novel TRPV5 inhibitors Elife. DOI: 10.7554/Elife.49572.041  0.556
2019 Jiang Y, Jara-Oseguera A. Decision letter: Regulatory switch at the cytoplasmic interface controls TRPV channel gating Elife. DOI: 10.7554/Elife.47746.037  0.49
2019 Chen Q, Zeng W, She J, Bai X, Jiang Y. Author response: Structural and functional characterization of an otopetrin family proton channel Elife. DOI: 10.7554/Elife.46710.024  0.794
2019 She J, Zeng W, Guo J, Chen Q, Bai X, Jiang Y. Author response: Structural mechanisms of phospholipid activation of the human TPC2 channel Elife. DOI: 10.7554/Elife.45222.030  0.836
2018 Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, ... ... Jiang Y, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. PMID 30333625 DOI: 10.1038/S41586-018-0615-Z  0.526
2018 Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y. Author Correction: Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature. PMID 30108362 DOI: 10.1038/S41586-018-0427-1  0.567
2018 Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y. Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature. PMID 29995855 DOI: 10.1038/S41586-018-0333-6  0.716
2018 She J, Guo J, Chen Q, Zeng W, Jiang Y, Bai XC. Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel. Nature. PMID 29562233 DOI: 10.1038/Nature26139  0.87
2017 Guo J, She J, Zeng W, Chen Q, Bai XC, Jiang Y. Structures of the calcium-activated, non-selective cation channel TRPM4. Nature. 552: 205-209. PMID 29211714 DOI: 10.1038/Nature24997  0.857
2017 Chen Q, She J, Zeng W, Guo J, Xu H, Bai XC, Jiang Y. Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature. PMID 29019981 DOI: 10.1038/Nature24035  0.871
2017 Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, Jiang Y. The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature. PMID 28723891 DOI: 10.1038/Nature23269  0.871
2017 Guo J, Zeng W, Jiang Y. Tuning the ion selectivity of two-pore channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096396 DOI: 10.1016/J.Bpj.2016.11.1326  0.783
2017 Guo J, Zeng W, Jiang Y. Structure of the TPC1 Channel from Arabidopsis Thaliana Biophysical Journal. 112: 475a. DOI: 10.1016/J.Bpj.2016.11.2552  0.782
2016 Barthmes M, Liao J, Jiang Y, Brüggemann A, Wahl-Schott C. Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology. The Journal of General Physiology. 147: 485-96. PMID 27241699 DOI: 10.1085/Jgp.201611587  0.573
2016 Liao J, Marinelli F, Lee C, Huang Y, Faraldo-Gómez JD, Jiang Y. Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger. Nature Structural & Molecular Biology. PMID 27183196 DOI: 10.1038/Nsmb.3230  0.605
2015 Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y. Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana. Nature. PMID 26689363 DOI: 10.1038/Nature16446  0.769
2015 Lam YL, Zeng W, Derebe MG, Jiang Y. Structural implications of weak Ca2+ block in Drosophila cyclic nucleotide-gated channels. The Journal of General Physiology. 146: 255-63. PMID 26283200 DOI: 10.1085/Jgp.201511431  0.856
2015 Lee EE, Ma J, Sacharidou A, Mi W, Salato VK, Nguyen N, Jiang Y, Pascual JM, North PE, Shaul PW, Mettlen M, Wang RC. A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome. Molecular Cell. 58: 845-53. PMID 25982116 DOI: 10.1016/J.Molcel.2015.04.015  0.528
2015 Nguyen Y, Nguyen NX, Rogers JL, Liao J, MacMillan JB, Jiang Y, Sperandio V. Structural and mechanistic roles of novel chemical ligands on the SdiA quorum-sensing transcription regulator. Mbio. 6. PMID 25827420 DOI: 10.1128/Mbio.02429-14  0.668
2014 Lam YL, Zeng W, Sauer DB, Jiang Y. The conserved potassium channel filter can have distinct ion binding profiles: structural analysis of rubidium, cesium, and barium binding in NaK2K. The Journal of General Physiology. 144: 181-92. PMID 25024267 DOI: 10.1085/Jgp.201411191  0.846
2014 Barthmes M, Liao J, Wahl-Schott C, Jiang Y, Brüggemann A. Functional Characterization of Bacterial NCx by Surface Supported Membrane Technology Biophysical Journal. 106: 581a. DOI: 10.1016/J.Bpj.2013.11.3222  0.313
2013 Sauer DB, Zeng W, Canty J, Lam Y, Jiang Y. Sodium and potassium competition in potassium-selective and non-selective channels Nature Communications. 4. PMID 24217363 DOI: 10.1038/Ncomms3721  0.786
2013 John SA, Liao J, Jiang Y, Ottolia M. The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways. Proceedings of the National Academy of Sciences of the United States of America. 110: 7500-5. PMID 23589872 DOI: 10.1073/Pnas.1218751110  0.605
2012 Kong C, Zeng W, Ye S, Chen L, Sauer DB, Lam Y, Derebe MG, Jiang Y. Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. Elife. 1: e00184. PMID 23240087 DOI: 10.7554/Elife.00184  0.812
2012 Liao J, Li H, Zeng W, Sauer DB, Belmares R, Jiang Y. Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science (New York, N.Y.). 335: 686-90. PMID 22323814 DOI: 10.1126/Science.1215759  0.761
2012 Kong C, Zeng W, Ye S, Chen L, Sauer DB, Lam Y, Derebe MG, Jiang Y. Author response: Distinct gating mechanisms revealed by the structures of a multi-ligand gated K+ channel Elife. DOI: 10.7554/Elife.00184.016  0.78
2011 Sauer DB, Zenga W, Raghunathan S, Jiang Y. Protein interactions central to stabilizing the K + channel selectivity filter in a four-sited configuration for selective K + permeation Proceedings of the National Academy of Sciences of the United States of America. 108: 16634-16639. PMID 21933962 DOI: 10.1073/Pnas.1111688108  0.769
2011 Shi N, Zeng W, Ye S, Li Y, Jiang Y. Crucial points within the pore as determinants of K⁺ channel conductance and gating. Journal of Molecular Biology. 411: 27-35. PMID 21554888 DOI: 10.1016/J.Jmb.2011.04.058  0.636
2011 Alam A, Jiang Y. Structural studies of ion selectivity in tetrameric cation channels Journal of General Physiology. 137: 397-403. PMID 21518828 DOI: 10.1085/Jgp.201010546  0.836
2011 Cao Y, Jin X, Huang H, Derebe MG, Levin EJ, Kabaleeswaran V, Pan Y, Punta M, Love J, Weng J, Quick M, Ye S, Kloss B, Bruni R, Martinez-Hackert E, ... ... Jiang Y, et al. Crystal structure of a potassium ion transporter, TrkH. Nature. 471: 336-40. PMID 21317882 DOI: 10.1038/Nature09731  0.644
2011 Derebe MG, Zeng W, Li Y, Alam A, Jiang Y. Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proceedings of the National Academy of Sciences of the United States of America. 108: 592-7. PMID 21187429 DOI: 10.1073/Pnas.1013643108  0.865
2011 Derebe MG, Sauer DB, Zeng W, Alam A, Shi N, Jiang Y. Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites. Proceedings of the National Academy of Sciences of the United States of America. 108: 598-602. PMID 21187421 DOI: 10.1073/Pnas.1013636108  0.85
2010 Dorwart MR, Wray R, Brautigam CA, Jiang Y, Blount P. S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins. Plos Biology. 8: e1000555. PMID 21151884 DOI: 10.1371/Journal.Pbio.1000555  0.434
2010 Ye S, Li Y, Jiang Y. Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. Nature Structural & Molecular Biology. 17: 1019-23. PMID 20676101 DOI: 10.1038/Nsmb.1865  0.552
2010 Wu Y, Yang Y, Ye S, Jiang Y. Structure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channel. Nature. 466: 393-7. PMID 20574420 DOI: 10.1038/Nature09252  0.644
2010 Linn KM, Derebe MG, Jiang Y, Valiyaveetil FI. Semisynthesis of NaK, a Na(+) and K(+) conducting ion channel. Biochemistry. 49: 4450-6. PMID 20415433 DOI: 10.1021/Bi100413Z  0.522
2010 Derebe M, Zeng W, Jiang Y. Structural Insight into the Ion Selectivity and Ca2+ Blockage in Cyclic Nucleotide Gated Channels Biophysical Journal. 98: 707a. DOI: 10.1016/J.Bpj.2009.12.3876  0.67
2009 Alam A, Jiang Y. High-resolution structure of the open NaK channel Nature Structural and Molecular Biology. 16: 30-34. PMID 19098917 DOI: 10.1038/Nsmb.1531  0.858
2009 Alam A, Jiang Y. Structural analysis of ion selectivity in the NaK channel Nature Structural and Molecular Biology. 16: 35-41. PMID 19098915 DOI: 10.1038/Nsmb.1537  0.8
2009 Derebe M, Jiang Y. Insights into the Ion Selectivity Mechanism of CNG Channels from Mutants of NaK: Structural and Functional Studies Biophysical Journal. 96: 671a. DOI: 10.1016/J.Bpj.2008.12.3544  0.676
2007 Alam A, Shi N, Jiang Y. Structural insight into Ca2+ specificity in tetrameric cation channels. Proceedings of the National Academy of Sciences of the United States of America. 104: 15334-9. PMID 17878296 DOI: 10.1073/Pnas.0707324104  0.819
2007 Li Y, Berke I, Chen L, Jiang Y. Gating and inward rectifying properties of the MthK K+ channel with and without the gating ring. The Journal of General Physiology. 129: 109-20. PMID 17261840 DOI: 10.1085/Jgp.200609655  0.522
2006 Ye S, Li Y, Chen L, Jiang Y. Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels. Cell. 126: 1161-73. PMID 16990139 DOI: 10.1016/J.Cell.2006.08.029  0.631
2006 Shi N, Ye S, Alam A, Chen L, Jiang Y. Atomic structure of a Na+- and K+-conducting channel. Nature. 440: 570-4. PMID 16467789 DOI: 10.1038/Nature04508  0.862
2005 Dong J, Shi N, Berke I, Chen L, Jiang Y. Structures of the MthK RCK domain and the effect of Ca2+ on gating ring stability. The Journal of Biological Chemistry. 280: 41716-24. PMID 16227203 DOI: 10.1074/Jbc.M508144200  0.574
2003 Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R. The principle of gating charge movement in a voltage-dependent K+ channel. Nature. 423: 42-8. PMID 12721619 DOI: 10.1038/Nature01581  0.824
2003 Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R. X-ray structure of a voltage-dependent K+ channel. Nature. 423: 33-41. PMID 12721618 DOI: 10.1038/Nature01580  0.842
2003 Ruta V, Jiang Y, Lee A, Chen J, MacKinnon R. Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature. 422: 180-5. PMID 12629550 DOI: 10.1038/Nature01473  0.85
2002 Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. The open pore conformation of potassium channels. Nature. 417: 523-6. PMID 12037560 DOI: 10.1038/417523A  0.745
2002 Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417: 515-22. PMID 12037559 DOI: 10.1038/417515A  0.774
2001 Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron. 29: 593-601. PMID 11301020 DOI: 10.1016/S0896-6273(01)00236-7  0.789
2000 Jiang Y, MacKinnon R. The barium site in a potassium channel by x-ray crystallography. The Journal of General Physiology. 115: 269-72. PMID 10694255 DOI: 10.1085/Jgp.115.3.269  0.659
1997 Wang Y, Jiang Y, Meyering-Voss M, Sprinzl M, Sigler PB. Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus. Nature Structural Biology. 4: 650-6. PMID 9253415 DOI: 10.1038/Nsb0897-650  0.57
1996 Jiang Y, Nock S, Nesper M, Sprinzl M, Sigler PB. Structure and importance of the dimerization domain in elongation factor Ts from Thermus thermophilus. Biochemistry. 35: 10269-78. PMID 8756682 DOI: 10.1021/Bi960918W  0.571
1996 Jiang Y, Nock S, Nesper M, Sprinzl M, Sigler PB. Structure and importance of the dimerization domain in elongation factor Ts fromThermos thermophillus Acta Crystallographica Section a Foundations of Crystallography. 52: C187-C187. DOI: 10.1107/S0108767396091829  0.567
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