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Hans (Johannes Carolus) Clevers - Publications

Affiliations: 
1991- Utrecht University, Utrecht, Netherlands 
Area:
Molecular genetics, Molecular immunology
Website:
http://knaw.nl/nl/leden/leden/3984
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Year Citation  Score
2020 Saltsman JA, Hammond WJ, Narayan NJC, Requena D, Gehart H, Lalazar G, LaQuaglia MP, Clevers H, Simon S. A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing. Cancers. 12. PMID 32962010 DOI: 10.3390/Cancers12092668  0.305
2020 Beumer J, Clevers H. Cell fate specification and differentiation in the adult mammalian intestine. Nature Reviews Molecular Cell Biology. 22: 39-53. PMID 32958874 DOI: 10.1038/S41580-020-0278-0  0.487
2020 Pleguezuelos-Manzano C, Puschhof J, van den Brink S, Geurts V, Beumer J, Clevers H. Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells. Current Protocols in Immunology. 130: e106. PMID 32940424 DOI: 10.1002/Cpim.106  0.369
2020 Nikolaev M, Mitrofanova O, Broguiere N, Geraldo S, Dutta D, Tabata Y, Elci B, Brandenberg N, Kolotuev I, Gjorevski N, Clevers H, Lutolf MP. Homeostatic mini-intestines through scaffold-guided organoid morphogenesis. Nature. 585: 574-578. PMID 32939089 DOI: 10.1038/S41586-020-2724-8  0.433
2020 Driehuis E, Kretzschmar K, Clevers H. Establishment of patient-derived cancer organoids for drug-screening applications. Nature Protocols. 15: 3380-3409. PMID 32929210 DOI: 10.1038/S41596-020-0379-4  0.319
2020 Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, et al. LifeTime and improving European healthcare through cell-based interceptive medicine. Nature. PMID 32894860 DOI: 10.1038/S41586-020-2715-9  0.339
2020 Lõhmussaar K, Boretto M, Clevers H. Human-Derived Model Systems in Gynecological Cancer Research Trends in Cancer. 6: 1031-1043. PMID 32855097 DOI: 10.1016/J.Trecan.2020.07.007  0.304
2020 Hageman JH, Heinz MC, Kretzschmar K, Vaart Jvd, Clevers H, Snippert HJG. Intestinal Regeneration: Regulation by the Microenvironment. Developmental Cell. 54: 435-446. PMID 32841594 DOI: 10.1016/J.Devcel.2020.07.009  0.454
2020 Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, ... ... Clevers H, et al. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. Cell Stem Cell. PMID 32818433 DOI: 10.1016/J.Stem.2020.07.020  0.444
2020 Wei G, Gao N, Chen J, Fan L, Zeng Z, Gao G, Li L, Fang G, Hu K, Pang X, Fan HY, Clevers H, Liu M, Zhang X, Li D. ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation. Development (Cambridge, England). PMID 32747435 DOI: 10.1242/Dev.185678  0.443
2020 Mizutani T, Clevers H. Primary Intestinal Epithelial Organoid Culture. Methods of Molecular Biology. 2171: 185-200. PMID 32705642 DOI: 10.1007/978-1-0716-0747-3_11  0.47
2020 Boonekamp KE, Dayton TL, Clevers H. Intestinal organoids as tools for enriching and studying specific and rare cell types: advances and future directions. Journal of Molecular Cell Biology. 12: 562-568. PMID 32667995 DOI: 10.1093/Jmcb/Mjaa034  0.471
2020 Beumer J, Gehart H, Clevers H. Enteroendocrine Dynamics – New Tools Reveal Hormonal Plasticity in the Gut Endocrine Reviews. 41: 695-706. PMID 32531023 DOI: 10.1210/Endrev/Bnaa018  0.432
2020 Yengej FAY, Jansen J, Rookmaaker MB, Verhaar MC, Clevers H. Kidney Organoids and Tubuloids. Cells. 9: 1326. PMID 32466429 DOI: 10.3390/Cells9061326  0.356
2020 Lõhmussaar K, Kopper O, Korving J, Begthel H, Vreuls CPH, van Es JH, Clevers H. Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids. Nature Communications. 11: 2660. PMID 32461556 DOI: 10.1038/S41467-020-16432-0  0.326
2020 Driehuis E, Oosterom N, Heil SG, Muller IB, Lin M, Kolders S, Jansen G, de Jonge R, Pieters R, Clevers H, van den Heuvel-Eibrink MM. Patient-derived oral mucosa organoids as an in vitro model for methotrexate induced toxicity in pediatric acute lymphoblastic leukemia. Plos One. 15: e0231588. PMID 32421698 DOI: 10.1371/Journal.Pone.0231588  0.323
2020 Beumer J, Puschhof J, Bauzá-Martinez J, Martínez-Silgado A, Elmentaite R, James KR, Ross A, Hendriks D, Artegiani B, Busslinger GA, Ponsioen B, Andersson-Rolf A, Saftien A, Boot C, Kretzschmar K, ... ... Clevers H, et al. High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells. Cell. PMID 32407674 DOI: 10.1016/J.Cell.2020.04.036  0.334
2020 Vaart Jvd, Clevers H. Airway organoids as models of human disease Journal of Internal Medicine. 289: 604-613. PMID 32350962 DOI: 10.1111/Joim.13075  0.397
2020 Rosenbluth JM, Schackmann RCJ, Gray GK, Selfors LM, Li CM, Boedicker M, Kuiken HJ, Richardson A, Brock J, Garber J, Dillon D, Sachs N, Clevers H, Brugge JS. Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. Nature Communications. 11: 1711. PMID 32249764 DOI: 10.1038/S41467-020-15548-7  0.402
2020 Yan HHN, Siu HC, Ho SL, Yue SSK, Gao Y, Tsui WY, Chan D, Chan AS, Wong JWH, Man AHY, Lee BCH, Chan ASY, Chan AKW, Hui HS, Cheung AKL, ... ... Clevers H, et al. Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles. Gut. PMID 32217638 DOI: 10.1136/Gutjnl-2019-320019  0.339
2020 Wang D, Wang J, Bai L, Pan H, Feng H, Clevers H, Zeng YA. Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr Progenitors. Cell. 180: 1198-1211.e19. PMID 32200801 DOI: 10.1016/J.Cell.2020.02.048  0.416
2020 Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, ... ... Clevers H, et al. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nature Communications. 11: 1310. PMID 32161258 DOI: 10.1038/S41467-020-15155-6  0.355
2020 Ringel T, Frey N, Ringnalda F, Janjuha S, Cherkaoui S, Butz S, Srivatsa S, Pirkl M, Russo G, Villiger L, Rogler G, Clevers H, Beerenwinkel N, Zamboni N, Baubec T, et al. Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance. Cell Stem Cell. 26: 431-440.e8. PMID 32142663 DOI: 10.1016/J.Stem.2020.02.007  0.34
2020 Battich N, Beumer J, de Barbanson B, Krenning L, Baron CS, Tanenbaum ME, Clevers H, van Oudenaarden A. Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies. Science (New York, N.Y.). 367: 1151-1156. PMID 32139547 DOI: 10.1126/Science.Aax3072  0.391
2020 Pleguezuelos-Manzano C, Puschhof J, Huber AR, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, van der Linden R, ... ... Clevers H, et al. Mutational signature in colorectal cancer caused by genotoxic pks E. coli. Nature. PMID 32106218 DOI: 10.1038/S41586-020-2080-8  0.307
2020 Murata K, Jadhav U, Madha S, van Es J, Dean J, Cavazza A, Wucherpfennig K, Michor F, Clevers H, Shivdasani RA. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. PMID 32084390 DOI: 10.1016/J.Stem.2019.12.011  0.462
2020 Kruitwagen HS, Oosterhoff LA, van Wolferen ME, Chen C, Nantasanti Assawarachan S, Schneeberger K, Kummeling A, van Straten G, Akkerdaas IC, Vinke CR, van Steenbeek FG, van Bruggen LWL, Wolfswinkel J, Grinwis GCM, Fuchs SA, ... ... Clevers H, et al. Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a -Deficient Dog Model of Metabolic Liver Disease. Cells. 9. PMID 32053895 DOI: 10.3390/Cells9020410  0.318
2020 Post Y, Puschhof J, Beumer J, Kerkkamp HM, de Bakker MAG, Slagboom J, de Barbanson B, Wevers NR, Spijkers XM, Olivier T, Kazandjian TD, Ainsworth S, Iglesias CL, van de Wetering WJ, Heinz MC, ... ... Clevers H, et al. Snake Venom Gland Organoids. Cell. 180: 233-247.e21. PMID 31978343 DOI: 10.1016/J.Cell.2019.11.038  0.451
2020 Gao Y, Yan Y, Tripathi S, Pentinmikko N, Amaral A, Päivinen P, Domènech-Moreno E, Andersson S, Wong IPL, Clevers H, Katajisto P, Mäkelä TP. LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate. Gastroenterology. PMID 31930988 DOI: 10.1053/J.Gastro.2019.12.033  0.43
2020 Post Y, Clevers H. Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis. Cell Stem Cell. 25: 174-183. PMID 31374197 DOI: 10.1016/J.Stem.2019.07.002  0.433
2020 Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, Ineveld Rv, Derakhshan S, Custers L, Lijnzaad P, Begthel H, Kerstens H, Rookmaker M, Verhaar M, ... ... Clevers H, et al. Abstract IA27: Patient-derived organoids in pediatric cancer research Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-Ia27  0.35
2020 Puschhof J, Pleguezuelos-Manzano C, Huber AR, Bostel Rv, Clevers H. Abstract PR02: A mutational signature in human colorectal cancer induced by genotoxic pks+ E. coli Cancer Research. 80. DOI: 10.1158/1538-7445.Mvc2020-Pr02  0.329
2020 Gehart H, Clevers H. Stem Cell‐Derived Liver Cells Liver. 1015-1021. DOI: 10.1002/9781119436812.Ch77  0.381
2019 Bar-Ephraim YE, Kretzschmar K, Clevers H. Organoids in immunological research. Nature Reviews. Immunology. 20: 279-293. PMID 31853049 DOI: 10.1038/S41577-019-0248-Y  0.395
2019 van Es JH, Wiebrands K, López-Iglesias C, van de Wetering M, Zeinstra L, van den Born M, Korving J, Sasaki N, Peters PJ, van Oudenaarden A, Clevers H. Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion. Proceedings of the National Academy of Sciences of the United States of America. PMID 31843916 DOI: 10.1073/Pnas.1801888117  0.483
2019 Giobbe GG, Crowley C, Luni C, Campinoti S, Khedr M, Kretzschmar K, De Santis MM, Zambaiti E, Michielin F, Meran L, Hu Q, van Son G, Urbani L, Manfredi A, Giomo M, ... ... Clevers H, et al. Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture. Nature Communications. 10: 5658. PMID 31827102 DOI: 10.1038/S41467-019-13605-4  0.321
2019 Driehuis E, van Hoeck A, Moore K, Kolders S, Francies HE, Gulersonmez MC, Stigter ECA, Burgering B, Geurts V, Gracanin A, Bounova G, Morsink FH, Vries R, Boj S, van Es J, ... ... Clevers H, et al. Pancreatic cancer organoids recapitulate disease and allow personalized drug screening. Proceedings of the National Academy of Sciences of the United States of America. PMID 31818951 DOI: 10.1073/Pnas.1911273116  0.321
2019 Kretzschmar K, Clevers H. IFN-γ: The T cell’s license to kill stem cells in the inflamed intestine Science Immunology. 4. PMID 31811056 DOI: 10.1126/Sciimmunol.Aaz6821  0.379
2019 Schneeberger K, Sánchez-Romero N, Ye S, van Steenbeek FG, Oosterhoff LA, Pla Palacin I, Chen C, van Wolferen ME, van Tienderen G, Lieshout R, Colemonts-Vroninks H, Schene I, Hoekstra R, Verstegen MMA, van der Laan LJW, ... ... Clevers H, et al. Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells. Hepatology (Baltimore, Md.). PMID 31715015 DOI: 10.1002/Hep.31037  0.368
2019 Dekkers JF, Whittle JR, Vaillant F, Chen HR, Dawson C, Liu K, Geurts M, Herold MJ, Clevers H, Lindeman GJ, Visvader JE. Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids. Journal of the National Cancer Institute. PMID 31589320 DOI: 10.1093/Jnci/Djz196  0.311
2019 Schutgens F, Clevers H. Human Organoids: Tools for Understanding Biology and Treating Diseases. Annual Review of Pathology. 15: 211-234. PMID 31550983 DOI: 10.1146/Annurev-Pathmechdis-012419-032611  0.434
2019 Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, ... ... Clevers H, et al. Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Cell Stem Cell. PMID 31422913 DOI: 10.1016/J.Stem.2019.07.008  0.424
2019 Klotz BJ, Oosterhoff LA, Utomo L, Lim KS, Vallmajo-Martin Q, Clevers H, Woodfield TBF, Rosenberg AJWP, Malda J, Ehrbar M, Spee B, Gawlitta D. A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues. Advanced Healthcare Materials. e1900979. PMID 31402634 DOI: 10.1002/Adhm.201900979  0.376
2019 Fu YY, Egorova A, Sobieski C, Kuttiyara J, Calafiore M, Takashima S, Clevers H, Hanash AM. T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation. Immunity. PMID 31278057 DOI: 10.1016/J.Immuni.2019.06.003  0.42
2019 Joosten SPJ, Mizutani T, Spaargaren M, Clevers H, Pals ST. MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance. Gastroenterology. 157: 1153-1155.e1. PMID 31255653 DOI: 10.1053/J.Gastro.2019.06.029  0.38
2019 Boonekamp KE, Kretzschmar K, Wiener DJ, Asra P, Derakhshan S, Puschhof J, López-Iglesias C, Peters PJ, Basak O, Clevers H. Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures. Proceedings of the National Academy of Sciences of the United States of America. PMID 31253707 DOI: 10.1073/Pnas.1715272116  0.407
2019 Wang H, Xiang D, Liu B, He A, Randle HJ, Zhang KX, Dongre A, Sachs N, Clark AP, Tao L, Chen Q, Botchkarev VV, Xie Y, Dai N, Clevers H, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 178: 135-151.e19. PMID 31251913 DOI: 10.1016/J.Cell.2019.06.002  0.353
2019 Tuveson D, Clevers H. Cancer modeling meets human organoid technology. Science (New York, N.Y.). 364: 952-955. PMID 31171691 DOI: 10.1126/Science.Aaw6985  0.375
2019 Artegiani B, van Voorthuijsen L, Lindeboom RGH, Seinstra D, Heo I, Tapia P, López-Iglesias C, Postrach D, Dayton T, Oka R, Hu H, van Boxtel R, van Es JH, Offerhaus J, Peters PJ, ... ... Clevers H, et al. Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids. Cell Stem Cell. PMID 31130514 DOI: 10.1016/J.Stem.2019.04.017  0.335
2019 Driehuis E, Kolders S, Spelier S, Lohmussaar K, Willems SM, Devriese LA, de Bree R, de Ruiter EJ, Korving J, Begthel H, Van Es JH, Geurts V, He GW, van Jaarsveld RH, Oka R, ... ... Clevers H, et al. Oral mucosal organoids as a potential platform for personalized cancer therapy. Cancer Discovery. PMID 31053628 DOI: 10.1158/2159-8290.Cd-18-1522  0.301
2019 Bolhaqueiro ACF, Ponsioen B, Bakker B, Klaasen SJ, Kucukkose E, van Jaarsveld RH, Vivié J, Verlaan-Klink I, Hami N, Spierings DCJ, Sasaki N, Dutta D, Boj SF, Vries RGJ, Lansdorp PM, ... ... Clevers H, et al. Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids. Nature Genetics. PMID 31036964 DOI: 10.1038/S41588-019-0399-6  0.323
2019 Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, ... ... Clevers H, et al. An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity. Nature Medicine. PMID 31011202 DOI: 10.1038/S41591-019-0422-6  0.304
2019 Schutgens F, Rookmaaker MB, Margaritis T, Rios A, Ammerlaan C, Jansen J, Gijzen L, Vormann M, Vonk A, Viveen M, Yengej FY, Derakhshan S, de Winter-de Groot KM, Artegiani B, van Boxtel R, ... ... Clevers H, et al. Tubuloids derived from human adult kidney and urine for personalized disease modeling. Nature Biotechnology. 37: 303-313. PMID 30833775 DOI: 10.1038/S41587-019-0048-8  0.34
2019 Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, et al. Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors. Science Immunology. 4. PMID 30824528 DOI: 10.1126/Sciimmunol.Aaw1941  0.322
2019 Li N, Babaei-Jadidi R, Lorenzi F, Spencer-Dene B, Clarke P, Domingo E, Tulchinsky E, Vries RGJ, Kerr D, Pan Y, He Y, Bates DO, Tomlinson I, Clevers H, Nateri AS. An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance. Oncogenesis. 8: 13. PMID 30783098 DOI: 10.1038/s41389-019-0125-3  0.359
2019 Fakhiri J, Schneider MA, Puschhof J, Stanifer M, Schildgen V, Holderbach S, Voss Y, El Andari J, Schildgen O, Boulant S, Meister M, Clevers H, Yan Z, Qiu J, Grimm D. Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses. Molecular Therapy. Methods & Clinical Development. 12: 202-222. PMID 30766894 DOI: 10.1016/J.Omtm.2019.01.003  0.327
2019 Gehart H, van Es JH, Hamer K, Beumer J, Kretzschmar K, Dekkers JF, Rios A, Clevers H. Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping. Cell. PMID 30712869 DOI: 10.1016/J.Cell.2018.12.029  0.373
2019 Basham KJ, Rodriguez S, Turcu AF, Lerario AM, Logan CY, Rysztak MR, Gomez-Sanchez CE, Breault DT, Koo BK, Clevers H, Nusse R, Val P, Hammer GD. A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis. Genes & Development. PMID 30692207 DOI: 10.1101/Gad.317412.118  0.32
2019 Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, ... ... Clevers H, et al. Long-term expanding human airway organoids for disease modeling. The Embo Journal. PMID 30643021 DOI: 10.15252/Embj.2018100300  0.394
2019 Flanagan D, Barker N, Di Costanzo NS, Mason EA, Gurney A, Meniel VS, Koushyar S, Austin CR, Pearson HB, Boussioutas A, Clevers H, Phesse TJ, Vincan E. Frizzled-7 is required for Wnt signaling in gastric tumors with and without Apc mutations. Cancer Research. PMID 30622113 DOI: 10.1158/0008-5472.Can-18-2095  0.368
2019 Gehart H, Clevers H. Tales from the crypt: new insights into intestinal stem cells. Nature Reviews. Gastroenterology & Hepatology. 16: 19-34. PMID 30429586 DOI: 10.1038/S41575-018-0081-Y  0.484
2019 Artegiani B, Clevers H. Use and application of 3D-organoid technology. Human Molecular Genetics. 27: R99-R107. PMID 29796608 DOI: 10.1093/Hmg/Ddy187  0.346
2019 Clevers H. Expanding Impact of Stem Cell Science. Stem Cell Reports. 10: 1427-1428. PMID 29742387 DOI: 10.1016/J.Stemcr.2018.04.017  0.392
2019 Drost J, Clevers H. Organoids in cancer research. Nature Reviews. Cancer. 18: 407-418. PMID 29692415 DOI: 10.1038/S41568-018-0007-6  0.36
2019 Rios AC, Clevers H. Imaging organoids: a bright future ahead. Nature Methods. 15: 24-26. PMID 29298292 DOI: 10.1038/Nmeth.4537  0.37
2019 Cosgun KN, Deb G, Yang X, Xiao G, Sadras T, Lee J, Chan LN, Kume K, Yang L, Geng H, Chan J, Song JY, Jumaa H, Polson AG, Clevers H, et al. Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation Blood. 134: 748-748. DOI: 10.1182/Blood-2019-127263  0.387
2019 Zinzalla V, Drobits-Handl B, Savchenko A, Rinnenthal J, Bauer MJ, Sanderson M, Blake SM, Schweifer N, Vries RGJ, Clevers H, Kraut N. Abstract DDT01-01: BI 905677: A first-in-class LRP5/6 antagonist targeting Wnt-driven proliferation and immune escape Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-Ddt01-01  0.385
2019 Queiroz K, Driehuis E, Bonilla S, Lanz H, Clevers H, Joore J, Vulto P. Abstract 1173: A novel high throughput platform for head & neck cancer organoids drug screening Cancer Research. 79: 1173-1173. DOI: 10.1158/1538-7445.Am2019-1173  0.314
2019 Clevers H, Beumer J. Induction of different human enteroendocrine cells in intestinal organoids Protocol Exchange. DOI: 10.1038/Protex.2018.077  0.389
2018 Kretzschmar K, Post Y, Bannier-Hélaouët M, Mattiotti A, Drost J, Basak O, Li VSW, van den Born M, Gunst QD, Versteeg D, Kooijman L, van der Elst S, van Es JH, van Rooij E, van den Hoff MJB, ... Clevers H, et al. Profiling proliferative cells and their progeny in damaged murine hearts. Proceedings of the National Academy of Sciences of the United States of America. 115: E12245-E12254. PMID 30530645 DOI: 10.1073/Pnas.1805829115  0.386
2018 Fujii M, Clevers H, Sato T. Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids. Gastroenterology. 156: 562-576. PMID 30476497 DOI: 10.1053/J.Gastro.2018.11.048  0.364
2018 Lehle AS, Farin HF, Marquardt B, Michels BE, Magg T, Li Y, Liu Y, Ghalandary M, Lammens K, Hollizeck S, Rohlfs M, Hauck F, Conca R, Walz C, Weiss B, ... ... Clevers H, et al. Intestinal Inflammation and Dysregulated Immunity in Patients with Inherited Caspase-8 Deficiency. Gastroenterology. PMID 30267714 DOI: 10.1053/J.Gastro.2018.09.041  0.349
2018 Sasaki N, Clevers H. Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology. Current Opinion in Genetics & Development. 52: 117-122. PMID 30261425 DOI: 10.1016/J.Gde.2018.09.001  0.319
2018 Puschhof J, Clevers H. The Myofibroblasts' War on Drugs. Developmental Cell. 46: 669-670. PMID 30253163 DOI: 10.1016/J.Devcel.2018.09.008  0.321
2018 Beumer J, Clevers H. ROCKin' Intestinal Cell Fate: A Potential Avenue to Improve Glucose Sensitivity. Gastroenterology. 155: 974-976. PMID 30201364 DOI: 10.1053/J.Gastro.2018.09.005  0.31
2018 Schmitt M, Schewe M, Sacchetti A, Feijtel D, van de Geer WS, Teeuwssen M, Sleddens HF, Joosten R, van Royen ME, van de Werken HJG, van Es J, Clevers H, Fodde R. Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling. Cell Reports. 24: 2312-2328.e7. PMID 30157426 DOI: 10.1016/J.Celrep.2018.07.085  0.464
2018 Dijkstra KK, Cattaneo CM, Weeber F, Chalabi M, van de Haar J, Fanchi LF, Slagter M, van der Velden DL, Kaing S, Kelderman S, van Rooij N, van Leerdam ME, Depla A, Smit EF, Hartemink KJ, ... ... Clevers H, et al. Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids. Cell. PMID 30100188 DOI: 10.1016/J.Cell.2018.07.009  0.357
2018 Beumer J, Artegiani B, Post Y, Reimann F, Gribble F, Nguyen TN, Zeng H, Van den Born M, Van Es JH, Clevers H. Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient. Nature Cell Biology. PMID 30038251 DOI: 10.1038/S41556-018-0143-Y  0.39
2018 Heo I, Dutta D, Schaefer DA, Iakobachvili N, Artegiani B, Sachs N, Boonekamp KE, Bowden G, Hendrickx APA, Willems RJL, Peters PJ, Riggs MW, O'Connor R, Clevers H. Modelling Cryptosporidium infection in human small intestinal and lung organoids. Nature Microbiology. 3: 814-823. PMID 29946163 DOI: 10.1038/S41564-018-0177-8  0.312
2018 Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville T, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, ... ... Clevers H, et al. Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discovery. PMID 29853643 DOI: 10.1158/2159-8290.Cd-18-0349  0.304
2018 Chen C, Jochems P, Salz L, Schneeberger K, Penning LC, van de Graaf SFJ, Beuers U, Clevers H, Geijsen N, Masereeuw R, Spee B. Bioengineered bile ducts recapitulate key cholangiocyte functions. Biofabrication. PMID 29848792 DOI: 10.1088/1758-5090/Aac8Fd  0.365
2018 Chakrabarti R, Celià-Terrassa T, Kumar S, Hang X, Wei Y, Choudhury A, Hwang J, Peng J, Nixon B, Grady JJ, DeCoste C, Gao J, van Es JH, Li MO, Aifantis I, ... Clevers H, et al. Notch ligand Dll1 mediates cross-talk between mammary stem cells and the macrophageal niche. Science (New York, N.Y.). PMID 29773667 DOI: 10.1126/Science.Aan4153  0.326
2018 Grinenko T, Eugster A, Thielecke L, Ramasz B, Krüger A, Dietz S, Glauche I, Gerbaulet A, von Bonin M, Basak O, Clevers H, Chavakis T, Wielockx B. Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice. Nature Communications. 9: 1898. PMID 29765026 DOI: 10.1038/S41467-018-04188-7  0.459
2018 Harris A, Siggers P, Corrochano S, Warr N, Sagar D, Grimes DT, Suzuki M, Burdine RD, Cong F, Koo BK, Clevers H, Stévant I, Nef S, Wells S, Brauner R, et al. ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29735715 DOI: 10.1073/Pnas.1801223115  0.352
2018 Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB, Behjati S, Mitchell TJ, Grossmann S, Lightfoot H, Egan DA, Pronk A, Smakman N, van Gorp J, Anderson E, Gamble SJ, ... ... Clevers H, et al. Intra-tumour diversification in colorectal cancer at the single-cell level. Nature. PMID 29643510 DOI: 10.1038/S41586-018-0024-3  0.397
2018 Borten MA, Bajikar SS, Sasaki N, Clevers H, Janes KA. Automated brightfield morphometry of 3D organoid populations by OrganoSeg. Scientific Reports. 8: 5319. PMID 29593296 DOI: 10.1038/S41598-017-18815-8  0.301
2018 Loomans CJM, Williams Giuliani N, Balak J, Ringnalda F, van Gurp L, Huch M, Boj SF, Sato T, Kester L, de Sousa Lopes SMC, Roost MS, Bonner-Weir S, Engelse MA, Rabelink TJ, Heimberg H, ... ... Clevers H, et al. Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential. Stem Cell Reports. 10: 712-724. PMID 29539434 DOI: 10.1016/J.Stemcr.2018.02.005  0.404
2018 Clevers H, Watt FM. Defining Adult Stem Cells by Function, Not by Phenotype. Annual Review of Biochemistry. PMID 29494240 DOI: 10.1146/Annurev-Biochem-062917-012341  0.455
2018 Basak O, Krieger TG, Muraro MJ, Wiebrands K, Stange DE, Frias-Aldeguer J, Rivron NC, van de Wetering M, van Es JH, van Oudenaarden A, Simons BD, Clevers H. Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311336 DOI: 10.1073/Pnas.1715911114  0.435
2018 Linnekamp JF, Hooff SRV, Prasetyanti PR, Kandimalla R, Buikhuisen JY, Fessler E, Ramesh P, Lee KAST, Bochove GGW, de Jong JH, Cameron K, Leersum RV, Rodermond HM, Franitza M, Nürnberg P, ... ... Clevers H, et al. Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models. Cell Death and Differentiation. PMID 29305587 DOI: 10.1038/S41418-017-0011-5  0.373
2018 Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, ... ... Clevers H, et al. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell. 172: 373-386.e10. PMID 29224780 DOI: 10.1016/J.Cell.2017.11.010  0.321
2018 Jager M, Blokzijl F, Sasselli V, Boymans S, Janssen R, Besselink N, Clevers H, van Boxtel R, Cuppen E. Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures. Nature Protocols. 13: 59-78. PMID 29215633 DOI: 10.1038/Nprot.2017.111  0.341
2018 Cosgun KN, Deb G, Yang X, Xiao G, Sadras T, Auer F, Lee J, Abarientos A, Mangolini M, Aghajanirefah A, Geng H, Jumaa H, Polson AG, Clevers H, Muschen M. Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies Blood. 132: 547-547. DOI: 10.1182/Blood-2018-99-116956  0.317
2018 Rosenbluth JM, Schackmann R, Li C, Sachs N, Dillon D, Richardson A, Brock J, Garber J, Gray GK, Zoeller J, Boedicker M, Kuiken HJ, Clevers H, Brugge J. Abstract 989: Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages and can form chimeric mammary glands in vivo Cancer Research. 78: 989-989. DOI: 10.1158/1538-7445.Am2018-989  0.412
2018 Cosgun KN, Hecht A, Yang X, Mangolini M, Aghajanirefah A, Xiao G, Sadras T, Chen Z, Klemm L, Geng H, Hong C, Song Q, Zeng D, Jumaa H, Zeng D, ... Clevers H, et al. Abstract 4515: Lgr5 mediates positive B-cell selection and is critical for initiation and survival of B-cell malignancies Cancer Research. 78: 4515-4515. DOI: 10.1158/1538-7445.Am2018-4515  0.426
2018 Cosgun KN, Yang X, Mangolini M, Xiao G, Abarientos A, Aghajanirefah A, Klemm L, Sadras T, Geng H, Yang L, Song Q, Zeng D, Zeng D, Jumaa H, Polson A, ... Clevers H, et al. LGR5 Mediates Positive B-Cell Selection and is Critical for Survival of Normal and Transformed B Cells Experimental Hematology. 64: S59-S60. DOI: 10.1016/J.Exphem.2018.06.206  0.307
2018 Fu Y, Egorova A, Sobieski C, Calafiore M, Clevers H, Hanash AM. The Intestinal Stem Cell Compartment is the Initial Target of T Cell Invasion in GI Gvhd Biology of Blood and Marrow Transplantation. 24: S67. DOI: 10.1016/J.Bbmt.2017.12.638  0.427
2017 Duarte AA, Gogola E, Sachs N, Barazas M, Annunziato S, R de Ruiter J, Velds A, Blatter S, Houthuijzen JM, van de Ven M, Clevers H, Borst P, Jonkers J, Rottenberg S. BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance. Nature Methods. PMID 29256493 DOI: 10.1038/Nmeth.4535  0.312
2017 Artegiani B, Lyubimova A, Muraro M, van Es JH, van Oudenaarden A, Clevers H. A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche. Cell Reports. 21: 3271-3284. PMID 29241552 DOI: 10.1016/J.Celrep.2017.11.050  0.387
2017 Schutgens F, Rookmaaker MB, Blokzijl F, van Boxtel R, Vries R, Cuppen E, Verhaar MC, Clevers H. Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney. Proceedings of the National Academy of Sciences of the United States of America. 114: E11190-E11198. PMID 29237753 DOI: 10.1073/Pnas.1714145115  0.428
2017 Ren Z, van Andel H, de Lau W, Hartholt RB, Maurice MM, Clevers H, Kersten MJ, Spaargaren M, Pals ST. Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins. Blood. PMID 29212806 DOI: 10.1182/Blood-2017-07-797050  0.374
2017 Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell PJ, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, et al. Science Forum: The Human Cell Atlas. Elife. 6. PMID 29206104 DOI: 10.7554/Elife.27041  0.392
2017 Batlle E, Clevers H. Cancer stem cells revisited. Nature Medicine. 23: 1124-1134. PMID 28985214 DOI: 10.1038/Nm.4409  0.449
2017 Drost J, van Boxtel R, Blokzijl F, Mizutani T, Sasaki N, Sasselli V, de Ligt J, Behjati S, Grolleman JE, van Wezel T, Nik-Zainal S, Kuiper RP, Cuppen E, Clevers H. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer. Science (New York, N.Y.). 358: 234-238. PMID 28912133 DOI: 10.1126/Science.Aao3130  0.333
2017 Joosten SPJ, Zeilstra J, van Andel H, Mijnals RC, Zaunbrecher J, Duivenvoorden AAM, van de Wetering M, Clevers H, Spaargaren M, Pals ST. MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms. Gastroenterology. PMID 28716720 DOI: 10.1053/J.Gastro.2017.07.008  0.417
2017 Beumer J, Clevers H. How the Gut Feels, Smells, and Talks. Cell. 170: 10-11. PMID 28666112 DOI: 10.1016/J.Cell.2017.06.023  0.325
2017 Andersson-Rolf A, Zilbauer M, Koo BK, Clevers H. Stem Cells in Repair of Gastrointestinal Epithelia. Physiology (Bethesda, Md.). 32: 278-289. PMID 28615312 DOI: 10.1152/Physiol.00005.2017  0.367
2017 Flanagan DJ, Barker N, Nowell C, Clevers H, Ernst M, Phesse TJ, Vincan E. Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo. Disease Models & Mechanisms. PMID 28600348 DOI: 10.1242/Dmm.029876  0.379
2017 Nusse R, Clevers H. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell. 169: 985-999. PMID 28575679 DOI: 10.1016/J.Cell.2017.05.016  0.414
2017 Kretzschmar K, Clevers H. Wnt/β-catenin signaling in adult mammalian epithelial stem cells. Developmental Biology. 428: 273-282. PMID 28526587 DOI: 10.1016/J.Ydbio.2017.05.015  0.451
2017 Lasrado R, Boesmans W, Kleinjung J, Pin C, Bell D, Bhaw L, McCallum S, Zong H, Luo L, Clevers H, Vanden Berghe P, Pachnis V. Lineage-dependent spatial and functional organization of the mammalian enteric nervous system. Science (New York, N.Y.). 356: 722-726. PMID 28522527 DOI: 10.1126/Science.Aam7511  0.352
2017 Mizutani T, Tsukamoto Y, Clevers H. Oncogene-inducible organoids as a miniature platform to assess cancer characteristics. The Journal of Cell Biology. 216: 1505-1507. PMID 28512141 DOI: 10.1083/Jcb.201704014  0.352
2017 Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, et al. Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature. PMID 28467818 DOI: 10.1038/Nature22306  0.419
2017 Dayton TL, Clevers H. Beyond growth signaling: Paneth cells metabolically support ISCs. Cell Research. 27: 851-852. PMID 28429766 DOI: 10.1038/Cr.2017.59  0.45
2017 Bartfeld S, Clevers H. Stem cell-derived organoids and their application for medical research and patient treatment. Journal of Molecular Medicine (Berlin, Germany). 95: 729-738. PMID 28391362 DOI: 10.1007/S00109-017-1531-7  0.376
2017 Dutta D, Heo I, Clevers H. Disease Modeling in Stem Cell-Derived 3D Organoid Systems. Trends in Molecular Medicine. PMID 28341301 DOI: 10.1016/J.Molmed.2017.02.007  0.41
2017 Kretzschmar K, Clevers H. Everything has its time: Id2 clocks embryonic specification of Lgr5(+) gut stem cells. The Embo Journal. 36: 837-839. PMID 28298434 DOI: 10.15252/Embj.201796482  0.424
2017 Sachs N, Tsukamoto Y, Kujala P, Peters PJ, Clevers H. Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels. Development (Cambridge, England). 144: 1107-1112. PMID 28292848 DOI: 10.1242/Dev.143933  0.431
2017 Drost J, Clevers H. Translational applications of adult stem cell-derived organoids. Development (Cambridge, England). 144: 968-975. PMID 28292843 DOI: 10.1242/Dev.140566  0.403
2017 Fumagalli A, Drost J, Suijkerbuijk SJ, van Boxtel R, de Ligt J, Offerhaus GJ, Begthel H, Beerling E, Tan EH, Sansom OJ, Cuppen E, Clevers H, van Rheenen J. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proceedings of the National Academy of Sciences of the United States of America. PMID 28270604 DOI: 10.1073/Pnas.1701219114  0.372
2017 Tüysüz N, van Bloois L, van den Brink S, Begthel H, Verstegen MM, Cruz LJ, Hui L, van der Laan LJ, de Jonge J, Vries R, Braakman E, Mastrobattista E, Cornelissen JJ, Clevers H, Ten Berge D. Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells. Nature Communications. 8: 14578. PMID 28262686 DOI: 10.1038/Ncomms14578  0.407
2017 Driehuis E, Clevers H. WNT signaling events near the cell membrane and their pharmacological targeting for the treatment of cancer. British Journal of Pharmacology. PMID 28244067 DOI: 10.1111/Bph.13758  0.353
2017 Öhlund D, Handly-Santana A, Biffi G, Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA, Lee EJ, Chio II, Hwang CI, Tiriac H, Baker LA, Engle DD, ... ... Clevers H, et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. The Journal of Experimental Medicine. PMID 28232471 DOI: 10.1084/Jem.20162024  0.405
2017 Schneeberger K, Spee B, Costa P, Sachs N, Clevers H, Malda J. Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering? Biofabrication. PMID 28211365 DOI: 10.1088/1758-5090/Aa6121  0.314
2017 Driehuis E, Clevers H. CRISPR/Cas 9 genome editing and its applications in organoids. American Journal of Physiology. Gastrointestinal and Liver Physiology. 312: G257-G265. PMID 28126704 DOI: 10.1152/Ajpgi.00410.2016  0.32
2017 Bredenoord AL, Clevers H, Knoblich JA. Human tissues in a dish: The research and ethical implications of organoid technology. Science (New York, N.Y.). 355. PMID 28104841 DOI: 10.1126/Science.Aaf9414  0.304
2017 Cristobal A, van den Toorn HW, van de Wetering M, Clevers H, Heck AJ, Mohammed S. Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer. Cell Reports. 18: 263-274. PMID 28052255 DOI: 10.1016/J.Celrep.2016.12.016  0.315
2017 Regev A, Teichmann SA, Lander ES, Amit I, Benoist C, Birney E, Bodenmiller B, Campbell P, Carninci P, Clatworthy M, Clevers H, Deplancke B, Dunham I, Eberwine J, Eils R, et al. Author response: The Human Cell Atlas Elife. DOI: 10.7554/Elife.27041.011  0.324
2017 Cosgun KNN, Hecht A, Yang X, Mangolini M, Aghajanirefah A, Chen Z, Xiao G, Klemm L, Hong C, Geng H, Jumaa H, Clevers H, Muschen M. Lgr5 Functions As Negative Regulator of Wnt Signaling in B Cells and Is Critical for Self-Renewal of Normal and Transformed B Cells Blood. 130: 3989-3989. DOI: 10.1182/Blood.V130.Suppl_1.3989.3989  0.417
2017 Clevers H. Abstract IA6: Lgr5 stem cell-based organoids in human disease Cancer Research. 77. DOI: 10.1158/1538-7445.Newfront17-Ia6  0.495
2017 Chan LH, Zhou L, Ng KY, Wong TL, Chai S, Lee TK, Guan XY, Ching YP, Lo CM, Man K, Artegiani B, Clevers H, Yan HH, Leung SY, Richard S, et al. Abstract LB-139: PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-139  0.393
2017 Roovers R, Herpers B, James M, Eppink B, Cortina C, Maussang-Detaille D, Kolfschoten I, Boy S, Wetering Mvd, Lau WD, Doornbos R, Yan K, Salinaro L, Bakker L, Kruif jd, ... Clevers H, et al. Abstract 32: Preclinical evaluation of MCLA-158: A bispecific antibody targeting LGR5 and EGFR using patient-derived colon carcinoma organoids Cancer Research. 77: 32-32. DOI: 10.1158/1538-7445.Am2017-32  0.347
2016 Hosokawa J, Suzuki K, Meguro K, Tanaka S, Maezawa Y, Suto A, Fujimura L, Sakamoto A, Clevers H, Ohara O, Nakajima H. IκBNS enhances T follicular helper cell differentiation and function as downstream of Ascl2. The Journal of Allergy and Clinical Immunology. PMID 28040417 DOI: 10.1016/J.Jaci.2016.10.047  0.377
2016 van Andel H, Ren Z, Koopmans I, Joosten SP, Kocemba KA, de Lau W, Kersten MJ, de Bruin AM, Guikema JE, Clevers H, Spaargaren M, Pals ST. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28028233 DOI: 10.1073/Pnas.1618650114  0.404
2016 Basak O, Beumer J, Wiebrands K, Seno H, van Oudenaarden A, Clevers H. Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells. Cell Stem Cell. PMID 27939219 DOI: 10.1016/J.Stem.2016.11.001  0.491
2016 Steinhart Z, Pavlovic Z, Chandrashekhar M, Hart T, Wang X, Zhang X, Robitaille M, Brown KR, Jaksani S, Overmeer R, Boj SF, Adams J, Pan J, Clevers H, Sidhu S, et al. Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature Medicine. PMID 27869803 DOI: 10.1038/Nm.4219  0.369
2016 Gjorevski N, Sachs N, Manfrin A, Giger S, Bragina ME, Ordóñez-Morán P, Clevers H, Lutolf MP. Designer matrices for intestinal stem cell and organoid culture. Nature. PMID 27851739 DOI: 10.1038/Nature20168  0.403
2016 Beumer J, Clevers H. Regulation and plasticity of intestinal stem cells during homeostasis and regeneration. Development (Cambridge, England). 143: 3639-3649. PMID 27802133 DOI: 10.1242/Dev.133132  0.467
2016 Tetteh PW, Kretzschmar K, Begthel H, van den Born M, Korving J, Morsink F, Farin H, van Es JH, Offerhaus GJ, Clevers H. Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research. Proceedings of the National Academy of Sciences of the United States of America. 113: 11859-11864. PMID 27708166 DOI: 10.1073/Pnas.1614057113  0.417
2016 Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, ... ... Clevers H, et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature. PMID 27698416 DOI: 10.1038/Nature19768  0.343
2016 Kretzschmar K, Clevers H. Organoids: Modeling Development and the Stem Cell Niche in a Dish. Developmental Cell. 38: 590-600. PMID 27676432 DOI: 10.1016/J.Devcel.2016.08.014  0.436
2016 Drost J, Artegiani B, Clevers H. The Generation of Organoids for Studying Wnt Signaling. Methods in Molecular Biology (Clifton, N.J.). 1481: 141-59. PMID 27590160 DOI: 10.1007/978-1-4939-6393-5_15  0.398
2016 Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, ... Clevers H, et al. Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573849 DOI: 10.1073/Pnas.1607327113  0.472
2016 Broutier L, Andersson-Rolf A, Hindley CJ, Boj SF, Clevers H, Koo BK, Huch M. Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation. Nature Protocols. 11: 1724-43. PMID 27560176 DOI: 10.1038/Nprot.2016.097  0.39
2016 Cammareri P, Rose AM, Vincent DF, Wang J, Nagano A, Libertini S, Ridgway RA, Athineos D, Coates PJ, McHugh A, Pourreyron C, Dayal JH, Larsson J, Weidlich S, Spender LC, ... ... Clevers H, et al. Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. Nature Communications. 7: 12493. PMID 27558455 DOI: 10.1038/Ncomms12493  0.419
2016 Drost J, Clevers H. Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding. Molecular Cell. 63: 352-4. PMID 27494556 DOI: 10.1016/J.Molcel.2016.07.013  0.308
2016 Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J, Xie M, Petersen J, Pachnis V, Nicolis SK, Yu T, Sharpe P, Arenas E, Brismar H, Blom H, ... Clevers H, et al. Analysis of neural crest-derived clones reveals novel aspects of facial development. Science Advances. 2: e1600060. PMID 27493992 DOI: 10.1126/Sciadv.1600060  0.368
2016 Grün D, Muraro MJ, Boisset JC, Wiebrands K, Lyubimova A, Dharmadhikari G, van den Born M, van Es J, Jansen E, Clevers H, de Koning EJ, van Oudenaarden A. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell Stem Cell. PMID 27345837 DOI: 10.1016/J.Stem.2016.05.010  0.455
2016 Clevers H. Modeling Development and Disease with Organoids. Cell. 165: 1586-1597. PMID 27315476 DOI: 10.1016/J.Cell.2016.05.082  0.32
2016 Boj SF, Hwang CI, Baker LA, Engle DD, Tuveson DA, Clevers H. Model organoids provide new research opportunities for ductal pancreatic cancer. Molecular & Cellular Oncology. 3: e1014757. PMID 27308531 DOI: 10.1080/23723556.2015.1014757  0.315
2016 Boers SN, van Delden JJ, Clevers H, Bredenoord AL. Organoid biobanking: identifying the ethics: Organoids revive old and raise new ethical challenges for basic research and therapeutic use. Embo Reports. 17: 938-41. PMID 27296278 DOI: 10.15252/Embr.201642613  0.402
2016 Schwank G, Clevers H. CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids. Methods in Molecular Biology (Clifton, N.J.). 1422: 3-11. PMID 27246017 DOI: 10.1007/978-1-4939-3603-8_1  0.382
2016 Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, De Sousa E Melo F, Prasetyanti PR, IJspeert JE, Franitza M, Nürnberg P, van Noesel CJ, Dekker E, Vermeulen L, Clevers H, et al. TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. Embo Molecular Medicine. PMID 27221051 DOI: 10.15252/Emmm.201606184  0.367
2016 Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, ... ... Clevers H, et al. Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation. Cell Stem Cell. PMID 27184401 DOI: 10.1016/J.Stem.2016.04.002  0.476
2016 Visvader JE, Clevers H. Tissue-specific designs of stem cell hierarchies. Nature Cell Biology. PMID 26999737 DOI: 10.1038/Ncb3332  0.437
2016 Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu LN, Weng Q, Mao M, Li J, van Es JH, Xin M, ... ... Clevers H, et al. Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation. Nature Communications. 7: 10883. PMID 26955760 DOI: 10.1038/Ncomms10883  0.323
2016 Kuijk EW, Rasmussen S, Blokzijl F, Huch M, Gehart H, Toonen P, Begthel H, Clevers H, Geurts AM, Cuppen E. Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure. Scientific Reports. 6: 22154. PMID 26915950 DOI: 10.1038/Srep22154  0.349
2016 Farin HF, Jordens I, Mosa MH, Basak O, Korving J, Tauriello DV, de Punder K, Angers S, Peters PJ, Maurice MM, Clevers H. Visualization of a short-range Wnt gradient in the intestinal stem-cell niche. Nature. PMID 26863187 DOI: 10.1038/Nature16937  0.46
2016 Tetteh PW, Basak O, Farin HF, Wiebrands K, Kretzschmar K, Begthel H, van den Born M, Korving J, de Sauvage F, van Es JH, van Oudenaarden A, Clevers H. Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters. Cell Stem Cell. 18: 203-13. PMID 26831517 DOI: 10.1016/J.Stem.2016.01.001  0.467
2016 Karin M, Clevers H. Reparative inflammation takes charge of tissue regeneration. Nature. 529: 307-15. PMID 26791721 DOI: 10.1038/Nature17039  0.305
2016 Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans BN, Vries RG, Clevers H, de Haan G, van Os R, Coppes RP. Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports. 6: 150-62. PMID 26724906 DOI: 10.1016/J.Stemcr.2015.11.009  0.475
2016 Herpers B, Roovers R, Eppink B, Wetering MVd, Yan K, Salinaro L, Lau WD, Clevers H, Vries R, Throsby M, Price L. Abstract PR05: A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-Pr05  0.402
2016 Clevers H. Abstract IA04: Lgr5 stem cell-based organoids in human disease Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-Ia04  0.497
2016 Baker LA, Tiriac H, Corbo V, Boj SF, Hwang C, Chio IIC, Engle DD, Jager M, Ponz-Sarvise M, Spector MS, Gracanin A, Oni T, Yu KH, Boxtel Rv, Huch M, ... ... Clevers H, et al. Abstract B16: Using human patient-derived organoids to identify genetic dependencies in pancreatic cancer Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B16  0.361
2016 Clevers H. Abstract IA12: Lgr5 stem cell-based organoids in human disease Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-Ia12  0.497
2016 Clevers H. Cancer therapy: Defining stemness Nature. 534: 176-177. DOI: 10.1038/534176A  0.372
2016 Herpers B, Roovers R, Ebbink B, Van de Wetering M, Yan K, Salinaro L, Clevers H, De Lau W, Vries R, Throsby M, Price L. A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids European Journal of Cancer. 61: S130-S131. DOI: 10.1016/S0959-8049(16)61462-4  0.344
2015 Clevers H. STEM CELLS. What is an adult stem cell? Science (New York, N.Y.). 350: 1319-20. PMID 26659043 DOI: 10.1126/Science.Aad7016  0.42
2015 Bartfeld S, Clevers H. Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori. Journal of Visualized Experiments : Jove. PMID 26650279 DOI: 10.3791/53359  0.381
2015 Füllgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, Linnarsson S, Simons BD, Clevers H, Toftgård R, Kasper M. Dynamics of Lgr6(+) Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem Cell Reports. PMID 26607954 DOI: 10.1016/J.Stemcr.2015.09.013  0.4
2015 Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V. The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system. Gut Microbes. 0. PMID 26558327 DOI: 10.1080/19490976.2015.1109767  0.328
2015 Weeber F, van de Wetering M, Hoogstraat M, Dijkstra KK, Krijgsman O, Kuilman T, Gadellaa-van Hooijdonk CG, van der Velden DL, Peeper DS, Cuppen EP, Vries RG, Clevers H, Voest EE. Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proceedings of the National Academy of Sciences of the United States of America. 112: 13308-11. PMID 26460009 DOI: 10.1073/Pnas.1516689112  0.317
2015 Nantasanti S, Spee B, Kruitwagen HS, Chen C, Geijsen N, Oosterhoff LA, van Wolferen ME, Pelaez N, Fieten H, Wubbolts RW, Grinwis GC, Chan J, Huch M, Vries RR, Clevers H, et al. Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports. PMID 26455412 DOI: 10.1016/J.Stemcr.2015.09.002  0.348
2015 Hwang CI, Boj SF, Clevers H, Tuveson DA. Pre-clinical Models of Pancreatic Ductal Adenocarcinoma. The Journal of Pathology. PMID 26419819 DOI: 10.1002/Path.4651  0.329
2015 Schneeberger K, Vogel GF, Teunissen H, van Ommen DD, Begthel H, El Bouazzaoui L, van Vugt AH, Beekman JM, Klumperman J, Müller T, Janecke A, Gerner P, Huber LA, Hess MW, Clevers H, et al. An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking. Proceedings of the National Academy of Sciences of the United States of America. PMID 26392529 DOI: 10.1073/Pnas.1516672112  0.363
2015 Koizumi M, Oyama K, Yamakami Y, Kida T, Satoh R, Kato S, Hidema S, Oe T, Goto T, Clevers H, Nawa A, Nishimori K. Lgr4 Controls Specialization of Female Gonads in Mice. Biology of Reproduction. PMID 26333992 DOI: 10.1095/Biolreprod.114.123638  0.33
2015 Grün D, Lyubimova A, Kester L, Wiebrands K, Basak O, Sasaki N, Clevers H, van Oudenaarden A. Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature. 525: 251-5. PMID 26287467 DOI: 10.1038/Nature14966  0.463
2015 Gregorieff A, Clevers H. In Situ Hybridization to Identify Gut Stem Cells. Current Protocols in Stem Cell Biology. 34: 2F.1.1-11. PMID 26237569 DOI: 10.1002/9780470151808.Sc02F01S34  0.43
2015 Rookmaaker MB, Schutgens F, Verhaar MC, Clevers H. Development and application of human adult stem or progenitor cell organoids. Nature Reviews. Nephrology. 11: 546-54. PMID 26215513 DOI: 10.1038/Nrneph.2015.118  0.405
2015 Heo I, Clevers H. Expanding intestinal stem cells in culture. Cell Research. 25: 995-6. PMID 26169607 DOI: 10.1038/cr.2015.83  0.311
2015 Sato T, Clevers H. SnapShot: Growing Organoids from Stem Cells. Cell. 161: 1700-1700.e1. PMID 26091044 DOI: 10.1016/J.Cell.2015.06.028  0.439
2015 Dow LE, O'Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. Cell. 161: 1539-52. PMID 26091037 DOI: 10.1016/J.Cell.2015.05.033  0.433
2015 Koo BK, van Es JH, van den Born M, Clevers H. Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia. Proceedings of the National Academy of Sciences of the United States of America. 112: 7548-50. PMID 26023187 DOI: 10.1073/Pnas.1508113112  0.406
2015 Gehart H, Clevers H. Repairing organs: lessons from intestine and liver. Trends in Genetics : Tig. 31: 344-51. PMID 25989898 DOI: 10.1016/J.Tig.2015.04.005  0.373
2015 van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F, Pronk A, van Houdt W, van Gorp J, Taylor-Weiner A, Kester L, McLaren-Douglas A, Blokker J, Jaksani S, Bartfeld S, Volckman R, ... ... Clevers H, et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell. 161: 933-45. PMID 25957691 DOI: 10.1016/J.Cell.2015.03.053  0.394
2015 Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, ... ... Clevers H, et al. Sequential cancer mutations in cultured human intestinal stem cells. Nature. 521: 43-7. PMID 25924068 DOI: 10.1038/Nature14415  0.471
2015 Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, et al. Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells. Stem Cell Reports. 4: 759-67. PMID 25892522 DOI: 10.1016/J.Stemcr.2015.03.003  0.495
2015 Kundu P, Genander M, Strååt K, Classon J, Ridgway RA, Tan EH, Björk J, Martling A, van Es J, Sansom OJ, Clevers H, Pettersson S, Frisén J. An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth. Science Translational Medicine. 7: 281ra44. PMID 25834110 DOI: 10.1126/Scitranslmed.3010567  0.429
2015 Baggiolini A, Varum S, Mateos JM, Bettosini D, John N, Bonalli M, Ziegler U, Dimou L, Clevers H, Furrer R, Sommer L. Premigratory and migratory neural crest cells are multipotent in vivo. Cell Stem Cell. 16: 314-22. PMID 25748934 DOI: 10.1016/J.Stem.2015.02.017  0.438
2015 Weren RD, Venkatachalam R, Cazier JB, Farin HF, Kets CM, de Voer RM, Vreede L, Verwiel ET, van Asseldonk M, Kamping EJ, Kiemeney LA, Neveling K, Aben KK, Carvajal-Carmona L, Nagtegaal ID, ... ... Clevers H, et al. Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development. The Journal of Pathology. 236: 155-64. PMID 25712196 DOI: 10.1002/Path.4520  0.329
2015 van Es JH, Clevers H. Generation and analysis of mouse intestinal tumors and organoids harboring APC and K-Ras mutations. Methods in Molecular Biology (Clifton, N.J.). 1267: 125-44. PMID 25636467 DOI: 10.1007/978-1-4939-2297-0_6  0.373
2015 Schuijers J, Junker JP, Mokry M, Hatzis P, Koo BK, Sasselli V, van der Flier LG, Cuppen E, van Oudenaarden A, Clevers H. Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts. Cell Stem Cell. 16: 158-70. PMID 25620640 DOI: 10.1016/J.Stem.2014.12.006  0.471
2015 Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V. Microbiota controls the homeostasis of glial cells in the gut lamina propria. Neuron. 85: 289-95. PMID 25578362 DOI: 10.1016/J.Neuron.2014.12.037  0.415
2015 Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, ... ... Clevers H, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 160: 324-38. PMID 25557080 DOI: 10.1016/J.Cell.2014.12.021  0.348
2015 Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J, ... ... Clevers H, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 160: 299-312. PMID 25533785 DOI: 10.1016/J.Cell.2014.11.050  0.401
2015 Petersen N, Reimann F, van Es JH, van den Berg BM, Kroone C, Pais R, Jansen E, Clevers H, Gribble FM, de Koning EJ. Targeting development of incretin-producing cells increases insulin secretion. The Journal of Clinical Investigation. 125: 379-85. PMID 25500886 DOI: 10.1172/Jci75838  0.307
2015 Cammareri P, Rose AM, Vincent DF, Libertini S, Ridgway RA, Athineos D, Coates P, McHugh A, Pourreyron C, Larsson J, Spender LC, Sapkota G, Purdie K, Proby C, Harwood CA, ... ... Clevers H, et al. Abstract 1506: Frequent loss of function mutations in TGFβR1 and TGFβR2 identify hair follicle bulge stem cells as the cell of origin for cutaneous squamous cell carcinoma Cancer Research. 75: 1506-1506. DOI: 10.1158/1538-7445.Am2015-1506  0.444
2014 Simmini S, Bialecka M, Huch M, Kester L, van de Wetering M, Sato T, Beck F, van Oudenaarden A, Clevers H, Deschamps J. Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2. Nature Communications. 5: 5728. PMID 25500896 DOI: 10.1038/Ncomms6728  0.465
2014 Tetteh PW, Farin HF, Clevers H. Plasticity within stem cell hierarchies in mammalian epithelia. Trends in Cell Biology. 25: 100-8. PMID 25308311 DOI: 10.1016/J.Tcb.2014.09.003  0.433
2014 Bartfeld S, Bayram T, van de Wetering M, Huch M, Begthel H, Kujala P, Vries R, Peters PJ, Clevers H. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology. 148: 126-136.e6. PMID 25307862 DOI: 10.1053/J.Gastro.2014.09.042  0.357
2014 Clevers H, Loh KM, Nusse R. Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science (New York, N.Y.). 346: 1248012. PMID 25278615 DOI: 10.1126/Science.1248012  0.44
2014 Vereecke L, Vieira-Silva S, Billiet T, van Es JH, Mc Guire C, Slowicka K, Sze M, van den Born M, De Hertogh G, Clevers H, Raes J, Rutgeerts P, Vermeire S, Beyaert R, van Loo G. A20 controls intestinal homeostasis through cell-specific activities. Nature Communications. 5: 5103. PMID 25267258 DOI: 10.1038/Ncomms6103  0.346
2014 Schuijers J, van der Flier LG, van Es J, Clevers H. Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus. Stem Cell Reports. 3: 234-41. PMID 25254337 DOI: 10.1016/J.Stemcr.2014.05.018  0.476
2014 Bolden JE, Tasdemir N, Dow LE, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW. Inducible in vivo silencing of Brd4 identifies potential toxicities of sustained BET protein inhibition. Cell Reports. 8: 1919-29. PMID 25242322 DOI: 10.1016/J.Celrep.2014.08.025  0.363
2014 Basak O, van de Born M, Korving J, Beumer J, van der Elst S, van Es JH, Clevers H. Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele. The Embo Journal. 33: 2057-68. PMID 25092767 DOI: 10.15252/Embj.201488017  0.468
2014 Kaukua N, Shahidi MK, Konstantinidou C, Dyachuk V, Kaucka M, Furlan A, An Z, Wang L, Hultman I, Ahrlund-Richter L, Blom H, Brismar H, Lopes NA, Pachnis V, Suter U, ... Clevers H, et al. Glial origin of mesenchymal stem cells in a tooth model system. Nature. 513: 551-4. PMID 25079316 DOI: 10.1038/Nature13536  0.455
2014 Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC, Tamuri AU, Martincorena I, Petljak M, Alexandrov LB, Gundem G, Tarpey PS, Roerink S, Blokker J, Maddison M, Mudie L, ... ... Clevers H, et al. Genome sequencing of normal cells reveals developmental lineages and mutational processes. Nature. 513: 422-5. PMID 25043003 DOI: 10.1038/Nature13448  0.368
2014 Farin HF, Karthaus WR, Kujala P, Rakhshandehroo M, Schwank G, Vries RG, Kalkhoven E, Nieuwenhuis EE, Clevers H. Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ. The Journal of Experimental Medicine. 211: 1393-405. PMID 24980747 DOI: 10.1084/Jem.20130753  0.366
2014 Liu D, He XC, Qian P, Barker N, Trainor PA, Clevers H, Liu H, Li L. Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development. The Journal of Biological Chemistry. 289: 23809-16. PMID 24966324 DOI: 10.1074/Jbc.M114.568170  0.45
2014 Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, et al. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports. 2: 838-52. PMID 24936470 DOI: 10.1016/J.Stemcr.2014.05.001  0.35
2014 Koo BK, Clevers H. Stem cells marked by the r-spondin receptor LGR5 Gastroenterology. 147: 289-302. PMID 24859206 DOI: 10.1053/J.Gastro.2014.05.007  0.473
2014 Wang K, Yuen ST, Xu J, Lee SP, Yan HH, Shi ST, Siu HC, Deng S, Chu KM, Law S, Chan KH, Chan AS, Tsui WY, Ho SL, Chan AK, ... ... Clevers H, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nature Genetics. 46: 573-82. PMID 24816253 DOI: 10.1038/Ng.2983  0.321
2014 Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, ... ... Clevers H, et al. Loss of syntaxin 3 causes variant microvillus inclusion disease. Gastroenterology. 147: 65-68.e10. PMID 24726755 DOI: 10.1053/J.Gastro.2014.04.002  0.304
2014 Nakaya T, Ogawa S, Manabe I, Tanaka M, Sanada M, Sato T, Taketo MM, Nakao K, Clevers H, Fukayama M, Kuroda M, Nagai R. KLF5 regulates the integrity and oncogenicity of intestinal stem cells. Cancer Research. 74: 2882-91. PMID 24626089 DOI: 10.1158/0008-5472.Can-13-2574  0.499
2014 Veleva-Rotse BO, Smart JL, Baas AF, Edmonds B, Zhao ZM, Brown A, Klug LR, Hansen K, Reilly G, Gardner AP, Subbiah K, Gaucher EA, Clevers H, Barnes AP. STRAD pseudokinases regulate axogenesis and LKB1 stability. Neural Development. 9: 5. PMID 24594058 DOI: 10.1186/1749-8104-9-5  0.313
2014 de Lau W, Peng WC, Gros P, Clevers H. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes & Development. 28: 305-16. PMID 24532711 DOI: 10.1101/Gad.235473.113  0.445
2014 Ritsma L, Ellenbroek SI, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. Nature. 507: 362-5. PMID 24531760 DOI: 10.1038/Nature12972  0.457
2014 Middendorp S, Schneeberger K, Wiegerinck CL, Mokry M, Akkerman RD, van Wijngaarden S, Clevers H, Nieuwenhuis EE. Adult stem cells in the small intestine are intrinsically programmed with their location-specific function. Stem Cells (Dayton, Ohio). 32: 1083-91. PMID 24496776 DOI: 10.1002/Stem.1655  0.48
2014 Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, et al. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature. 507: 513-8. PMID 24463518 DOI: 10.1038/Nature12910  0.401
2014 Schuijers J, Mokry M, Hatzis P, Cuppen E, Clevers H. Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. The Embo Journal. 33: 146-56. PMID 24413017 DOI: 10.1002/Embj.201385358  0.308
2014 Snippert HJ, Schepers AG, van Es JH, Simons BD, Clevers H. Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. Embo Reports. 15: 62-9. PMID 24355609 DOI: 10.1002/Embr.201337799  0.457
2014 Mokry M, Middendorp S, Wiegerinck CL, Witte M, Teunissen H, Meddens CA, Cuppen E, Clevers H, Nieuwenhuis EE. Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium. Gastroenterology. 146: 1040-7. PMID 24333384 DOI: 10.1053/J.Gastro.2013.12.003  0.306
2014 Bigorgne AE, Farin HF, Lemoine R, Mahlaoui N, Lambert N, Gil M, Schulz A, Philippet P, Schlesser P, Abrahamsen TG, Oymar K, Davies EG, Ellingsen CL, Leteurtre E, Moreau-Massart B, ... ... Clevers H, et al. TTC7A mutations disrupt intestinal epithelial apicobasal polarity. The Journal of Clinical Investigation. 124: 328-37. PMID 24292712 DOI: 10.1172/Jci71471  0.389
2014 Yin X, Farin HF, van Es JH, Clevers H, Langer R, Karp JM. Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny. Nature Methods. 11: 106-12. PMID 24292484 DOI: 10.1038/Nmeth.2737  0.446
2014 Hirsch D, Barker N, McNeil N, Hu Y, Camps J, McKinnon K, Clevers H, Ried T, Gaiser T. LGR5 positivity defines stem-like cells in colorectal cancer. Carcinogenesis. 35: 849-58. PMID 24282287 DOI: 10.1093/Carcin/Bgt377  0.486
2014 Petersen N, Reimann F, Bartfeld S, Farin HF, Ringnalda FC, Vries RG, van den Brink S, Clevers H, Gribble FM, de Koning EJ. Generation of L cells in mouse and human small intestine organoids. Diabetes. 63: 410-20. PMID 24130334 DOI: 10.2337/Db13-0991  0.377
2014 Clevers H. A gutsy approach to stem cells and signalling: an interview with Hans Clevers. Disease Models & Mechanisms. 6: 1053-6. PMID 24046385 DOI: 10.1242/Dmm.013367  0.424
2014 Fischer JM, Schepers AG, Clevers H, Shibata D, Liskay RM. Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis. 35: 237-46. PMID 23996931 DOI: 10.1093/Carcin/Bgt296  0.376
2014 Stange DE, Clevers H. Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors. Stem Cells (Dayton, Ohio). 31: 2287-95. PMID 23836510 DOI: 10.1002/Stem.1475  0.474
2014 Huch M, Boj SF, Clevers H. Lgr5(+) liver stem cells, hepatic organoids and regenerative medicine. Regenerative Medicine. 8: 385-7. PMID 23826690 DOI: 10.2217/Rme.13.39  0.36
2014 Zeilstra J, Joosten SP, van Andel H, Tolg C, Berns A, Snoek M, van de Wetering M, Spaargaren M, Clevers H, Pals ST. Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling. Oncogene. 33: 665-70. PMID 23318432 DOI: 10.1038/Onc.2012.611  0.4
2014 Vela I, Gao D, Gopalan A, Sboner A, Undvall E, Wanjala J, Iaquinta P, Wongvipat J, Karthaus W, Clevers H, Solomon SB, Beltran H, Kossai M, Mosquera JM, Rubin MA, et al. Development of novel metastatic prostate cancer cell lines by “organoid” in vitro culture technology. Journal of Clinical Oncology. 32: 33-33. DOI: 10.1200/Jco.2014.32.4_Suppl.33  0.325
2014 Bolden J, Tasdemir N, Dow L, Es JHv, Wilkinson JE, Zhao Z, Clevers H, Lowe SW. Abstract LB-40: Induciblein vivosilencing of Brd4 identifies potential toxicities of sustained BET protein inhibition Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-40  0.368
2014 Vries RGJ, Clevers H. Abstract LB-35: Living biobank of cancer organoids for drug development and screening Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-35  0.323
2014 Ponz-Sarvise M, Corbo V, Öhlund D, Oni T, Handly-Santana A, Engle D, Tiriac H, Chio C, Feigin M, Baker L, Ardito-Abraham C, Park Y, Hwang C, Elyada E, Yu K, ... Clevers H, et al. 194 Pancreatic ductal organoids as a new platform for drug discovery European Journal of Cancer. 50: 63. DOI: 10.1016/S0959-8049(14)70320-X  0.341
2014 Forster R, Chiba K, Schaeffer L, Regalado S, Lai C, Gao Q, Kiani S, Farin H, Clevers H, Cost G, Chan A, Rebar E, Urnov F, Gregory P, Pachter L, et al. Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells Stem Cell Reports. 3: 215. DOI: 10.1016/J.Stemcr.2014.06.014  0.434
2013 Sachs N, Clevers H. Organoid cultures for the analysis of cancer phenotypes. Current Opinion in Genetics & Development. 24: 68-73. PMID 24657539 DOI: 10.1016/J.Gde.2013.11.012  0.325
2013 Koo BK, Sasselli V, Clevers H. Retroviral gene expression control in primary organoid cultures. Current Protocols in Stem Cell Biology. 27: Unit 5A.6.. PMID 24510288 DOI: 10.1002/9780470151808.Sc05A06S27  0.327
2013 Peng WC, de Lau W, Madoori PK, Forneris F, Granneman JC, Clevers H, Gros P. Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling. Plos One. 8: e83110. PMID 24349440 DOI: 10.1371/Journal.Pone.0083110  0.305
2013 Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell. 13: 653-8. PMID 24315439 DOI: 10.1016/J.Stem.2013.11.002  0.422
2013 Schwank G, Andersson-Rolf A, Koo BK, Sasaki N, Clevers H. Generation of BAC transgenic epithelial organoids. Plos One. 8: e76871. PMID 24204693 DOI: 10.1371/Journal.Pone.0076871  0.317
2013 Stange DE, Koo BK, Huch M, Sibbel G, Basak O, Lyubimova A, Kujala P, Bartfeld S, Koster J, Geahlen JH, Peters PJ, Van Es JH, Van De Wetering M, Mills JC, Clevers H. XDifferentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium Cell. 155. PMID 24120136 DOI: 10.1016/J.Cell.2013.09.008  0.443
2013 Huch M, Bonfanti P, Boj SF, Sato T, Loomans CJ, van de Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ringnalda F, Begthel H, Hamer K, Mulder J, van Es JH, ... ... Clevers H, et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. The Embo Journal. 32: 2708-21. PMID 24045232 DOI: 10.1038/Emboj.2013.204  0.452
2013 Clevers H. The intestinal crypt, a prototype stem cell compartment. Cell. 154: 274-84. PMID 23870119 DOI: 10.1016/J.Cell.2013.07.004  0.44
2013 Pilz GA, Shitamukai A, Reillo I, Pacary E, Schwausch J, Stahl R, Ninkovic J, Snippert HJ, Clevers H, Godinho L, Guillemot F, Borrell V, Matsuzaki F, Götz M. Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type. Nature Communications. 4: 2125. PMID 23839311 DOI: 10.1038/Ncomms3125  0.314
2013 Peng WC, de Lau W, Forneris F, Granneman JC, Huch M, Clevers H, Gros P. Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5. Cell Reports. 3: 1885-92. PMID 23809763 DOI: 10.1016/J.Celrep.2013.06.009  0.315
2013 Sato T, Clevers H. Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (New York, N.Y.). 340: 1190-4. PMID 23744940 DOI: 10.1126/Science.1234852  0.45
2013 Dekkers JF, Wiegerinck CL, de Jonge HR, Bronsveld I, Janssens HM, de Winter-de Groot KM, Brandsma AM, de Jong NW, Bijvelds MJ, Scholte BJ, Nieuwenhuis EE, van den Brink S, Clevers H, van der Ent CK, Middendorp S, et al. A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nature Medicine. 19: 939-45. PMID 23727931 DOI: 10.1038/Nm.3201  0.313
2013 Barker N, Tan S, Clevers H. Lgr proteins in epithelial stem cell biology. Development (Cambridge, England). 140: 2484-94. PMID 23715542 DOI: 10.1242/Dev.083113  0.453
2013 Marko CK, Menon BB, Chen G, Whitsett JA, Clevers H, Gipson IK. Spdef null mice lack conjunctival goblet cells and provide a model of dry eye. The American Journal of Pathology. 183: 35-48. PMID 23665202 DOI: 10.1016/J.Ajpath.2013.03.017  0.385
2013 Bianco P, Barker R, Brüstle O, Cattaneo E, Clevers H, Daley GQ, De Luca M, Goldstein L, Lindvall O, Mummery C, Robey PG, Sattler de Sousa E Brito C, Smith A. Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. The Embo Journal. 32: 1489-95. PMID 23644381 DOI: 10.1038/Emboj.2013.114  0.349
2013 Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, et al. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. Plos Biology. 11: e1001536. PMID 23610556 DOI: 10.1371/Journal.Pbio.1001536  0.408
2013 Spijker HS, Ravelli RB, Mommaas-Kienhuis AM, van Apeldoorn AA, Engelse MA, Zaldumbide A, Bonner-Weir S, Rabelink TJ, Hoeben RC, Clevers H, Mummery CL, Carlotti F, de Koning EJ. Conversion of mature human β-cells into glucagon-producing α-cells. Diabetes. 62: 2471-80. PMID 23569174 DOI: 10.2337/Db12-1001  0.392
2013 Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M, Ferrante M, Lee AS, Onderwater JJ, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, ... Clevers H, et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Reports. 3: 1128-39. PMID 23545496 DOI: 10.1016/J.Celrep.2013.02.031  0.451
2013 Clevers H. Stem Cells: A unifying theory for the crypt. Nature. 495: 53-4. PMID 23446347 DOI: 10.1038/Nature11958  0.468
2013 Li VS, Clevers H. Intestinal regeneration: YAP-tumor suppressor and oncoprotein? Current Biology : Cb. 23: R110-2. PMID 23391384 DOI: 10.1016/J.Cub.2012.12.021  0.423
2013 Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature. 494: 247-50. PMID 23354049 DOI: 10.1038/Nature11826  0.471
2013 Boilève A, Senovilla L, Vitale I, Lissa D, Martins I, Métivier D, van den Brink S, Clevers H, Galluzzi L, Castedo M, Kroemer G. Immunosurveillance against tetraploidization-induced colon tumorigenesis. Cell Cycle (Georgetown, Tex.). 12: 473-9. PMID 23324343 DOI: 10.4161/Cc.23369  0.403
2013 Schwitalla S, Fingerle AA, Cammareri P, Nebelsiek T, Göktuna SI, Ziegler PK, Canli O, Heijmans J, Huels DJ, Moreaux G, Rupec RA, Gerhard M, Schmid R, Barker N, Clevers H, et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell. 152: 25-38. PMID 23273993 DOI: 10.1016/J.Cell.2012.12.012  0.445
2013 Wang L, Benedito R, Bixel MG, Zeuschner D, Stehling M, Sävendahl L, Haigh JJ, Snippert H, Clevers H, Breier G, Kiefer F, Adams RH. Identification of a clonally expanding haematopoietic compartment in bone marrow. The Embo Journal. 32: 219-30. PMID 23188081 DOI: 10.1038/Emboj.2012.308  0.405
2013 Sato T, Clevers H. Primary mouse small intestinal epithelial cell cultures. Methods in Molecular Biology (Clifton, N.J.). 945: 319-28. PMID 23097115 DOI: 10.1007/978-1-62703-125-7_19  0.443
2013 Abo A, Clevers H. Modulating WNT receptor turnover for tissue repair. Nature Biotechnology. 30: 835-6. PMID 22965053 DOI: 10.1038/Nbt.2361  0.408
2013 Clevers H. Abstract IA1: Lgr5 stem cells in self-renewal and cancer Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Ia1  0.498
2013 Clevers H. Abstract PL01-04: Wnt signaling, Lgr5 stem cells, and cancer. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Pl01-04  0.502
2013 Hirsch DD, Barker N, McNeil N, Hu Y, Camps J, McKinnon K, Clevers H, Ried T, Gaiser T. Abstract 5023: Stem cell hypothesis and function of Lgr5 in the development of colon cancer. Cancer Research. 73: 5023-5023. DOI: 10.1158/1538-7445.Am2013-5023  0.5
2013 Clevers H. Abstract KN01: Wnt signaling, Lgr5 stem cells, and cancer. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Kn01  0.504
2012 Huls G, van Es J, Clevers H, de Haan G, van Os R. Loss of Tcf7 diminishes hematopoietic stem/progenitor cell function. Leukemia. 27: 1613-4. PMID 23212152 DOI: 10.1038/Leu.2012.354  0.352
2012 Tiemessen MM, Baert MR, Schonewille T, Brugman MH, Famili F, Salvatori DC, Meijerink JP, Ozbek U, Clevers H, van Dongen JJ, Staal FJ. The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. Plos Biology. 10: e1001430. PMID 23185135 DOI: 10.1371/Journal.Pbio.1001430  0.393
2012 Staal FJ, Clevers H. Tales of the unexpected: Tcf1 functions as a tumor suppressor for leukemias. Immunity. 37: 761-3. PMID 23159221 DOI: 10.1016/J.Immuni.2012.10.008  0.332
2012 Clevers H. The Paneth cell, caloric restriction, and intestinal integrity. The New England Journal of Medicine. 367: 1560-1. PMID 23075184 DOI: 10.1056/Nejmcibr1208353  0.449
2012 Barker N, van Oudenaarden A, Clevers H. Identifying the stem cell of the intestinal crypt: strategies and pitfalls. Cell Stem Cell. 11: 452-60. PMID 23040474 DOI: 10.1016/J.Stem.2012.09.009  0.442
2012 van Es JH, Sato T, van de Wetering M, Lyubimova A, Nee AN, Gregorieff A, Sasaki N, Zeinstra L, van den Born M, Korving J, Martens AC, Barker N, van Oudenaarden A, Clevers H. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nature Cell Biology. 14: 1099-104. PMID 23000963 DOI: 10.1038/Ncb2581  0.473
2012 Barker N, Rookmaaker MB, Kujala P, Ng A, Leushacke M, Snippert H, van de Wetering M, Tan S, Van Es JH, Huch M, Poulsom R, Verhaar MC, Peters PJ, Clevers H. Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development. Cell Reports. 2: 540-52. PMID 22999937 DOI: 10.1016/J.Celrep.2012.08.018  0.446
2012 Kemper K, Prasetyanti PR, De Lau W, Rodermond H, Clevers H, Medema JP. Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells Stem Cells. 30: 2378-2386. PMID 22969042 DOI: 10.1002/Stem.1233  0.477
2012 de Visser KE, Ciampricotti M, Michalak EM, Tan DW, Speksnijder EN, Hau CS, Clevers H, Barker N, Jonkers J. Developmental stage-specific contribution of LGR5(+) cells to basal and luminal epithelial lineages in the postnatal mammary gland. The Journal of Pathology. 228: 300-9. PMID 22926799 DOI: 10.1002/Path.4096  0.47
2012 Lum L, Clevers H. Cell biology. The unusual case of Porcupine. Science (New York, N.Y.). 337: 922-3. PMID 22923569 DOI: 10.1126/Science.1228179  0.426
2012 Farin HF, Van Es JH, Clevers H. Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells. Gastroenterology. 143: 1518-1529.e7. PMID 22922422 DOI: 10.1053/J.Gastro.2012.08.031  0.475
2012 Koo BK, Spit M, Jordens I, Low TY, Stange DE, van de Wetering M, van Es JH, Mohammed S, Heck AJ, Maurice MM, Clevers H. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors. Nature. 488: 665-9. PMID 22895187 DOI: 10.1038/Nature11308  0.494
2012 Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proceedings of the National Academy of Sciences of the United States of America. 109: 14007-12. PMID 22893683 DOI: 10.1073/Pnas.1211509109  0.305
2012 Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (New York, N.Y.). 337: 730-5. PMID 22855427 DOI: 10.1126/Science.1224676  0.493
2012 Hua G, Thin TH, Feldman R, Haimovitz-Friedman A, Clevers H, Fuks Z, Kolesnick R. Crypt base columnar stem cells in small intestines of mice are radioresistant. Gastroenterology. 143: 1266-76. PMID 22841781 DOI: 10.1053/J.Gastro.2012.07.106  0.417
2012 Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL. Rap2A links intestinal cell polarity to brush border formation. Nature Cell Biology. 14: 793-801. PMID 22797597 DOI: 10.1038/Ncb2537  0.322
2012 de Lau W, Kujala P, Schneeberger K, Middendorp S, Li VS, Barker N, Martens A, Hofhuis F, DeKoter RP, Peters PJ, Nieuwenhuis E, Clevers H. Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Molecular and Cellular Biology. 32: 3639-47. PMID 22778137 DOI: 10.1128/Mcb.00434-12  0.438
2012 Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, ... ... Clevers H, et al. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. The Embo Journal. 31: 3079-91. PMID 22692129 DOI: 10.1038/Emboj.2012.166  0.468
2012 Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, Clevers H. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell. 149: 1245-56. PMID 22682247 DOI: 10.1016/J.Cell.2012.05.002  0.318
2012 Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell. 149: 1192-205. PMID 22682243 DOI: 10.1016/J.Cell.2012.05.012  0.32
2012 Buske P, Przybilla J, Loeffler M, Sachs N, Sato T, Clevers H, Galle J. On the biomechanics of stem cell niche formation in the gut--modelling growing organoids. The Febs Journal. 279: 3475-87. PMID 22632461 DOI: 10.1111/J.1742-4658.2012.08646.X  0.442
2012 Schuijers J, Clevers H. Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. The Embo Journal. 31: 2685-96. PMID 22617424 DOI: 10.1038/Emboj.2012.149  0.47
2012 Li VS, Clevers H. In vitro expansion and transplantation of intestinal crypt stem cells. Gastroenterology. 143: 30-4. PMID 22613623 DOI: 10.1053/J.Gastro.2012.05.017  0.515
2012 Guardavaccaro D, Clevers H. Wnt/β-catenin and MAPK signaling: allies and enemies in different battlefields. Science Signaling. 5: pe15. PMID 22494969 DOI: 10.1126/Scisignal.2002921  0.328
2012 Schepers A, Clevers H. Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harbor Perspectives in Biology. 4: a007989. PMID 22474007 DOI: 10.1101/Cshperspect.A007989  0.435
2012 Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, Watanabe M. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nature Medicine. 18: 618-23. PMID 22406745 DOI: 10.1038/Nm.2695  0.437
2012 Lander AD, Kimble J, Clevers H, Fuchs E, Montarras D, Buckingham M, Calof AL, Trumpp A, Oskarsson T. What does the concept of the stem cell niche really mean today? Bmc Biology. 10: 19. PMID 22405133 DOI: 10.1186/1741-7007-10-19  0.458
2012 van Es JH, Haegebarth A, Kujala P, Itzkovitz S, Koo BK, Boj SF, Korving J, van den Born M, van Oudenaarden A, Robine S, Clevers H. A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal. Molecular and Cellular Biology. 32: 1918-27. PMID 22393260 DOI: 10.1128/MCB.06288-11  0.347
2012 Wong VW, Stange DE, Page ME, Buczacki S, Wabik A, Itami S, van de Wetering M, Poulsom R, Wright NA, Trotter MW, Watt FM, Winton DJ, Clevers H, Jensen KB. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nature Cell Biology. 14: 401-8. PMID 22388892 DOI: 10.1038/Ncb2464  0.48
2012 Itzkovitz S, Blat IC, Jacks T, Clevers H, van Oudenaarden A. Optimality in the development of intestinal crypts. Cell. 148: 608-19. PMID 22304925 DOI: 10.1016/J.Cell.2011.12.025  0.438
2012 Basak O, Clevers H. Neural stem cells for diabetes cell-based therapy. Embo Molecular Medicine. 3: 698-700. PMID 22238783 DOI: 10.1002/Emmm.201100178  0.411
2012 Stringer EJ, Duluc I, Saandi T, Davidson I, Bialecka M, Sato T, Barker N, Clevers H, Pritchard CA, Winton DJ, Wright NA, Freund JN, Deschamps J, Beck F. Cdx2 determines the fate of postnatal intestinal endoderm. Development (Cambridge, England). 139: 465-74. PMID 22190642 DOI: 10.1242/Dev.070722  0.437
2012 Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A. Single-molecule transcript counting of stem-cell markers in the mouse intestine. Nature Cell Biology. 14: 106-14. PMID 22119784 DOI: 10.1038/Ncb2384  0.468
2012 Clevers H. 1 Lgr5 Stem Cells in Self-renewal and Cancer European Journal of Cancer. 48: S1. DOI: 10.1182/Blood.V124.21.Sci-40.Sci-40  0.494
2012 Clevers H. Abstract PL02-02: Lgr5 ctem cells in self-renewal and cancer Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Pl02-02  0.501
2012 Li VS, Ng SS, Karthaus WR, Gerlach JP, Mohammed S, Heck A, Maurice MM, Mahmoudi T, Clevers H. Abstract 983: Wnt pathway activation involves inhibition of β-catenin ubiquitination within the endogenous Axin1 complex Cancer Research. 72: 983-983. DOI: 10.1158/1538-7445.Am2012-983  0.351
2012 Stange D, Munoz J, Heck A, Clevers H. The Lgr5 positive intestinal stem cell signature Zeitschrift FüR Gastroenterologie. 50. DOI: 10.1055/s-0032-1324022  0.312
2012 Schuijers J, Clevers H. Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins The Embo Journal. 31: 3031-3032. DOI: 10.1038/Emboj.2012.177  0.375
2011 Koo BK, Stange DE, Sato T, Karthaus W, Farin HF, Huch M, van Es JH, Clevers H. Controlled gene expression in primary Lgr5 organoid cultures. Nature Methods. 9: 81-3. PMID 22138822 DOI: 10.1038/Nmeth.1802  0.302
2011 Dalerba P, Kalisky T, Sahoo D, Rajendran PS, Rothenberg ME, Leyrat AA, Sim S, Okamoto J, Johnston DM, Qian D, Zabala M, Bueno J, Neff NF, Wang J, Shelton AA, ... ... Clevers H, et al. Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nature Biotechnology. 29: 1120-7. PMID 22081019 DOI: 10.1038/Nbt.2038  0.429
2011 Jung P, Sato T, Merlos-Suárez A, Barriga FM, Iglesias M, Rossell D, Auer H, Gallardo M, Blasco MA, Sancho E, Clevers H, Batlle E. Isolation and in vitro expansion of human colonic stem cells. Nature Medicine. 17: 1225-7. PMID 21892181 DOI: 10.1038/Nm.2470  0.465
2011 Sato T, Stange DE, Ferrante M, Vries RG, Van Es JH, Van den Brink S, Van Houdt WJ, Pronk A, Van Gorp J, Siersema PD, Clevers H. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology. 141: 1762-72. PMID 21889923 DOI: 10.1053/J.Gastro.2011.07.050  0.393
2011 Snippert HJ, Schepers AG, Delconte G, Siersema PD, Clevers H. Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment. Nature Protocols. 6: 1221-8. PMID 21799490 DOI: 10.1038/Nprot.2011.365  0.301
2011 Van Houdt WJ, Emmink BL, Pham TV, Piersma SR, Verheem A, Vries RG, Fratantoni SA, Pronk A, Clevers H, Borel Rinkes IH, Jimenez CR, Kranenburg O. Comparative proteomics of colon cancer stem cells and differentiated tumor cells identifies BIRC6 as a potential therapeutic target. Molecular & Cellular Proteomics : McP. 10: M111.011353. PMID 21788403 DOI: 10.1074/Mcp.M111.011353  0.465
2011 Simons BD, Clevers H. Stem cell self-renewal in intestinal crypt. Experimental Cell Research. 317: 2719-24. PMID 21787769 DOI: 10.1016/J.Yexcr.2011.07.010  0.469
2011 de Lau W, Barker N, Low TY, Koo BK, Li VS, Teunissen H, Kujala P, Haegebarth A, Peters PJ, van de Wetering M, Stange DE, van Es JE, Guardavaccaro D, Schasfoort RB, Mohri Y, ... ... Clevers H, et al. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 476: 293-7. PMID 21727895 DOI: 10.1038/Nature10337  0.4
2011 Froeling FE, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart IR, Kocher HM. Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression. Gastroenterology. 141: 1486-97, 1497.e1-14. PMID 21704588 DOI: 10.1053/J.Gastro.2011.06.047  0.397
2011 Di Palma S, Stange D, van de Wetering M, Clevers H, Heck AJ, Mohammed S. Highly sensitive proteome analysis of FACS-sorted adult colon stem cells. Journal of Proteome Research. 10: 3814-9. PMID 21696214 DOI: 10.1021/Pr200367P  0.332
2011 Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, et al. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell. 19: 776-91. PMID 21665151 DOI: 10.1016/J.Ccr.2011.05.008  0.304
2011 Simons BD, Clevers H. Strategies for homeostatic stem cell self-renewal in adult tissues. Cell. 145: 851-62. PMID 21663791 DOI: 10.1016/J.Cell.2011.05.033  0.433
2011 Emmink BL, Van Houdt WJ, Vries RG, Hoogwater FJ, Govaert KM, Verheem A, Nijkamp MW, Steller EJ, Jimenez CR, Clevers H, Borel Rinkes IH, Kranenburg O. Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan. Gastroenterology. 141: 269-78. PMID 21459094 DOI: 10.1053/J.Gastro.2011.03.052  0.386
2011 Merlos-Suárez A, Barriga FM, Jung P, Iglesias M, Céspedes MV, Rossell D, Sevillano M, Hernando-Momblona X, da Silva-Diz V, Muñoz P, Clevers H, Sancho E, Mangues R, Batlle E. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell. 8: 511-24. PMID 21419747 DOI: 10.1016/J.Stem.2011.02.020  0.474
2011 Clevers H. The cancer stem cell: premises, promises and challenges. Nature Medicine. 17: 313-9. PMID 21386835 DOI: 10.1038/Nm.2304  0.427
2011 Gerbe F, van Es JH, Makrini L, Brulin B, Mellitzer G, Robine S, Romagnolo B, Shroyer NF, Bourgaux JF, Pignodel C, Clevers H, Jay P. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. The Journal of Cell Biology. 192: 767-80. PMID 21383077 DOI: 10.1083/Jcb.201010127  0.475
2011 van der Velden YU, Wang L, Zevenhoven J, van Rooijen E, van Lohuizen M, Giles RH, Clevers H, Haramis AP. The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108: 4358-63. PMID 21368212 DOI: 10.1073/Pnas.1010210108  0.324
2011 Schepers AG, Vries R, van den Born M, van de Wetering M, Clevers H. Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes. The Embo Journal. 30: 1104-9. PMID 21297579 DOI: 10.1038/Emboj.2011.26  0.456
2011 Buske P, Galle J, Barker N, Aust G, Clevers H, Loeffler M. A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt. Plos Computational Biology. 7: e1001045. PMID 21253562 DOI: 10.1371/Journal.Pcbi.1001045  0.44
2011 Snippert HJ, Clevers H. Tracking adult stem cells. Embo Reports. 12: 113-22. PMID 21252944 DOI: 10.1038/Embor.2010.216  0.44
2011 Huch M, Clevers H. Sox9 marks adult organ progenitors. Nature Genetics. 43: 9-10. PMID 21217637 DOI: 10.1038/Ng0111-9  0.369
2011 Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 469: 415-8. PMID 21113151 DOI: 10.1038/Nature09637  0.483
2011 Barker N, Bartfeld S, Clevers H. Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell. 7: 656-70. PMID 21112561 DOI: 10.1016/J.Stem.2010.11.016  0.432
2011 Demarque MD, Nacerddine K, Neyret-Kahn H, Andrieux A, Danenberg E, Jouvion G, Bomme P, Hamard G, Romagnolo B, Terris B, Cumano A, Barker N, Clevers H, Dejean A. Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice. Gastroenterology. 140: 286-96. PMID 20951138 DOI: 10.1053/J.Gastro.2010.10.002  0.365
2011 Verhaegh W, Hatzis P, Clevers H, van dSA. P5-04-03: Personalized Cancer Treatment Selection Using Computational Signaling Pathway Models. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P5-04-03  0.355
2011 Froeling F, Chelala C, Clevers H, Hart I, Kocher H. Retinoic Acid-Induced Stellate Cell Quiescence Results in Sfrp4 Secretion Which Abrogates Wnt-β-Catenin Signalling Pathway Modulating Human Pancreatic Tumour Cell Behaviour Gastroenterology. 140: S-156-S-157. DOI: 10.1016/S0016-5085(11)60635-5  0.384
2011 Yui S, Nakamura T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Sato T, Clevers H, Watanabe M. Regeneration of Damaged Colonic Tissue by Transplantation of Colonic Epithelial Stem Cells Maintained and Expanded In Vitro Gastroenterology. 140: S-102. DOI: 10.1016/S0016-5085(11)60416-2  0.4
2011 Petersen N, van Gurp L, Farin H, van den Brink S, Clevers H, de Koning E. PS5 - 26. Modulation of GLP-1 secreting L-cells derived from intestinal stem cells Nederlands Tijdschrift Voor Diabetologie. 9: 108-108. DOI: 10.1007/S12467-011-0051-2  0.303
2010 Mahmoudi T, Boj SF, Hatzis P, Li VS, Taouatas N, Vries RG, Teunissen H, Begthel H, Korving J, Mohammed S, Heck AJ, Clevers H. The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. Plos Biology. 8: e1000539. PMID 21103407 DOI: 10.1371/Journal.Pbio.1000539  0.417
2010 Qiu W, Wang X, Leibowitz B, Liu H, Barker N, Okada H, Oue N, Yasui W, Clevers H, Schoen RE, Yu J, Zhang L. Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 20027-32. PMID 21041628 DOI: 10.1073/Pnas.1010430107  0.429
2010 Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, Barker N, Marchesi F, Thirunarayanan N, Vischer HF, Qin L, Mayer L, Harpaz N, Leurs R, Furtado GC, Clevers H, et al. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. The Journal of Clinical Investigation. 120: 3969-78. PMID 20978345 DOI: 10.1172/Jci42563  0.405
2010 Cole AM, Ridgway RA, Derkits SE, Parry L, Barker N, Clevers H, Clarke AR, Sansom OJ. P21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium Embo Molecular Medicine. 2: 472-486. PMID 20976827 DOI: 10.1002/Emmm.201000101  0.323
2010 van Es JH, de Geest N, van de Born M, Clevers H, Hassan BA. Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nature Communications. 1: 18. PMID 20975679 DOI: 10.1038/Ncomms1017  0.491
2010 Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 143: 134-44. PMID 20887898 DOI: 10.1016/J.Cell.2010.09.016  0.459
2010 Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ. Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Research. 70: 8149-58. PMID 20736363 DOI: 10.1158/0008-5472.Can-10-0315  0.365
2010 Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, et al. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Developmental Cell. 19: 259-69. PMID 20708588 DOI: 10.1016/J.Devcel.2010.07.015  0.368
2010 Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch JP, Dang DT, Brown M, Clevers H, Liu XS, Shivdasani RA. TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions. Proceedings of the National Academy of Sciences of the United States of America. 107: 15157-62. PMID 20696899 DOI: 10.1073/Pnas.1003822107  0.401
2010 Vries RG, Huch M, Clevers H. Stem cells and cancer of the stomach and intestine. Molecular Oncology. 4: 373-84. PMID 20598659 DOI: 10.1016/J.Molonc.2010.05.001  0.464
2010 Verheyen EM, Clevers H. Wnts as self-renewal factors: mammary stem cells and beyond. Cell Stem Cell. 6: 494-5. PMID 20569681 DOI: 10.1016/J.Stem.2010.05.004  0.45
2010 Kosinski C, Stange DE, Xu C, Chan AS, Ho C, Yuen ST, Mifflin RC, Powell DW, Clevers H, Leung SY, Chen X. Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology. 139: 893-903. PMID 20542037 DOI: 10.1053/J.Gastro.2010.06.014  0.306
2010 Barker N, Clevers H. Lineage tracing in the intestinal epithelium. Current Protocols in Stem Cell Biology. Unit5A.4. PMID 20443207 DOI: 10.1002/9780470151808.Sc05A04S13  0.456
2010 Barker N, Clevers H. Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology. 138: 1681-96. PMID 20417836 DOI: 10.1053/J.Gastro.2010.03.002  0.471
2010 Oerlemans MI, Goumans MJ, van Middelaar B, Clevers H, Doevendans PA, Sluijter JP. Active Wnt signaling in response to cardiac injury. Basic Research in Cardiology. 105: 631-41. PMID 20373104 DOI: 10.1007/S00395-010-0100-9  0.375
2010 Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H, Maurice MM. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Molecular Cell. 37: 607-19. PMID 20227366 DOI: 10.1016/J.Molcel.2010.01.035  0.368
2010 Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (New York, N.Y.). 327: 1385-9. PMID 20223988 DOI: 10.1126/Science.1184733  0.44
2010 Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker N, Clevers H, Ridgway RA, Sansom OJ, Näthke IS. Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell. 6: 175-81. PMID 20144789 DOI: 10.1016/J.Stem.2009.12.007  0.465
2010 Sue Ng S, Mahmoudi T, Li VS, Hatzis P, Boersema PJ, Mohammed S, Heck AJ, Clevers H. MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biological Chemistry. 391: 171-80. PMID 20128690 DOI: 10.1515/Bc.2010.028  0.36
2010 Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science (New York, N.Y.). 327: 542-5. PMID 20110496 DOI: 10.1126/Science.1180794  0.438
2010 Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, ... ... Clevers H, et al. Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell. 6: 25-36. PMID 20085740 DOI: 10.1016/J.Stem.2009.11.013  0.457
2010 Menke V, van Es JH, de Lau W, van den Born M, Kuipers EJ, Siersema PD, de Bruin RW, Kusters JG, Clevers H. Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition. Disease Models & Mechanisms. 3: 104-10. PMID 20075383 DOI: 10.1242/Dmm.003012  0.417
2010 Clevers H. Searching for adult stem cells in the intestine. Embo Molecular Medicine. 1: 255-9. PMID 20049728 DOI: 10.1002/Emmm.200900034  0.453
2010 Gregorieff A, Clevers H. UNIT 2F.1 In Situ Hybridization to Identify Gut Stem Cells Current Protocols in Stem Cell Biology. Unit 2F.1. PMID 20049690 DOI: 10.1002/9780470151808.Sc02F01S12  0.405
2010 Ng SS, Mahmoudi T, Danenberg E, Bejaoui I, de Lau W, Korswagen HC, Schutte M, Clevers H. Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. The Journal of Biological Chemistry. 284: 35308-13. PMID 19850932 DOI: 10.1074/Jbc.M109.078261  0.319
2010 Hollestelle A, Nagel JH, Smid M, Lam S, Elstrodt F, Wasielewski M, Ng SS, French PJ, Peeters JK, Rozendaal MJ, Riaz M, Koopman DG, Ten Hagen TL, de Leeuw BH, Zwarthoff EC, ... ... Clevers H, et al. Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Research and Treatment. 121: 53-64. PMID 19593635 DOI: 10.1007/S10549-009-0460-8  0.322
2010 Emmink BL, Houdt WJv, Vries RG, Hoogwater FJH, Jimenez CR, Clevers H, Rinkes IHMB, Kranenburg O. Abstract 4294: Differentiated colorectal cancer cells protect tumor-initiating cells from irinotecan Cancer Research. 70: 4294-4294. DOI: 10.1158/1538-7445.Am10-4294  0.422
2009 Faro A, Boj SF, Clevers H. Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish. Zebrafish. 6: 361-76. PMID 19929219 DOI: 10.1089/Zeb.2009.0617  0.453
2009 Clevers H. Eyeing up new Wnt pathway players. Cell. 139: 227-9. PMID 19837026 DOI: 10.1016/J.Cell.2009.09.027  0.301
2009 Mahmoudi T, Li VS, Ng SS, Taouatas N, Vries RG, Mohammed S, Heck AJ, Clevers H. The kinase TNIK is an essential activator of Wnt target genes. The Embo Journal. 28: 3329-40. PMID 19816403 DOI: 10.1038/Emboj.2009.285  0.372
2009 Chen G, Korfhagen TR, Xu Y, Kitzmiller J, Wert SE, Maeda Y, Gregorieff A, Clevers H, Whitsett JA. SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production. The Journal of Clinical Investigation. 119: 2914-24. PMID 19759516 DOI: 10.1172/Jci39731  0.405
2009 Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, Schlaudraff F, Liss B, Schirmacher P, Kestler H, Danenberg E, Barker N, Clevers H, Speicher MR, Rudolph KL. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nature Genetics. 41: 1138-43. PMID 19718028 DOI: 10.1038/Ng.426  0.338
2009 Gregorieff A, Stange DE, Kujala P, Begthel H, van den Born M, Korving J, Peters PJ, Clevers H. The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology. 137: 1333-45.e1-3. PMID 19549527 DOI: 10.1053/J.Gastro.2009.06.044  0.45
2009 Ye F, Chen Y, Hoang T, Montgomery RL, Zhao XH, Bu H, Hu T, Taketo MM, Van Es JH, Clevers H, Hsieh J, Bassel-Duby R, Olson EN, Lu QR. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the Β-catenin-TCF interaction Nature Neuroscience. 12: 829-838. PMID 19503085 DOI: 10.1038/Nn.2333  0.341
2009 Barker N, van Es JH, Jaks V, Kasper M, Snippert H, Toftgård R, Clevers H. Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells. Cold Spring Harbor Symposia On Quantitative Biology. 73: 351-6. PMID 19478326 DOI: 10.1101/Sqb.2008.72.003  0.447
2009 van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H. OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology. 137: 15-7. PMID 19450592 DOI: 10.1053/J.Gastro.2009.05.035  0.461
2009 Faro A, Boj SF, Ambrósio R, van den Broek O, Korving J, Clevers H. T-cell factor 4 (tcf7l2) is the main effector of Wnt signaling during zebrafish intestine organogenesis. Zebrafish. 6: 59-68. PMID 19374549 DOI: 10.1089/Zeb.2009.0580  0.423
2009 Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 459: 262-5. PMID 19329995 DOI: 10.1038/Nature07935  0.456
2009 Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H. Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology. 136: 2187-2194.e1. PMID 19324043 DOI: 10.1053/J.Gastro.2009.03.002  0.435
2009 van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell. 136: 903-12. PMID 19269367 DOI: 10.1016/J.Cell.2009.01.031  0.49
2009 Haegebarth A, Clevers H. Wnt signaling, lgr5, and stem cells in the intestine and skin. The American Journal of Pathology. 174: 715-21. PMID 19197002 DOI: 10.2353/Ajpath.2009.080758  0.482
2009 Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M, Danenberg E, Clarke AR, Sansom OJ, Clevers H. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 457: 608-11. PMID 19092804 DOI: 10.1038/Nature07602  0.501
2009 Offerhaus GJ, Milne AN, Oving IM, van Gijn ME, Hruban RH, Clevers H. A transgenic mouse model for "lipid hang-up", or why pathologists need to be involved in genetically engineered mouse modelling. Gut. 57: 1739-40. PMID 19022932 DOI: 10.1136/Gut.2008.161109  0.31
2009 van der Flier LG, Clevers H. Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annual Review of Physiology. 71: 241-60. PMID 18808327 DOI: 10.1146/Annurev.Physiol.010908.163145  0.486
2008 Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, Toftgård R. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nature Genetics. 40: 1291-9. PMID 18849992 DOI: 10.1038/Ng.239  0.455
2008 Barker N, van de Wetering M, Clevers H. The intestinal stem cell. Genes & Development. 22: 1856-64. PMID 18628392 DOI: 10.1101/Gad.1674008  0.453
2008 Goessling W, North TE, Lord AM, Ceol C, Lee S, Weidinger G, Bourque C, Strijbosch R, Haramis AP, Puder M, Clevers H, Moon RT, Zon LI. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology. 320: 161-74. PMID 18585699 DOI: 10.1016/J.Ydbio.2008.05.526  0.353
2008 Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U, Strobl LJ, Honjo T, Clevers H, Radtke F. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2 Embo Reports. 9: 377-383. PMID 18274550 DOI: 10.1038/Embor.2008.7  0.414
2008 Hatzis P, van der Flier LG, van Driel MA, Guryev V, Nielsen F, Denissov S, Nijman IJ, Koster J, Santo EE, Welboren W, Versteeg R, Cuppen E, van de Wetering M, Clevers H, Stunnenberg HG. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Molecular and Cellular Biology. 28: 2732-44. PMID 18268006 DOI: 10.1128/Mcb.02175-07  0.37
2008 Barker N, Clevers H. Tracking down the stem cells of the intestine: strategies to identify adult stem cells. Gastroenterology. 133: 1755-60. PMID 18054544 DOI: 10.1053/J.Gastro.2007.10.029  0.434
2008 Clevers H. Identification of stem cells in small intestine and colon by a single marker gene Lgr5 European Journal of Cancer Supplements. 6: 1. DOI: 10.1016/S1359-6349(08)71175-3  0.319
2007 Sabates-Bellver J, Van der Flier LG, de Palo M, Cattaneo E, Maake C, Rehrauer H, Laczko E, Kurowski MA, Bujnicki JM, Menigatti M, Luz J, Ranalli TV, Gomes V, Pastorelli A, Faggiani R, ... ... Clevers H, et al. Transcriptome profile of human colorectal adenomas. Molecular Cancer Research : McR. 5: 1263-75. PMID 18171984 DOI: 10.1158/1541-7786.Mcr-07-0267  0.432
2007 Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 449: 1003-7. PMID 17934449 DOI: 10.1038/Nature06196  0.489
2007 Muncan V, Faro A, Haramis AP, Hurlstone AF, Wienholds E, van Es J, Korving J, Begthel H, Zivkovic D, Clevers H. T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine. Embo Reports. 8: 966-73. PMID 17823612 DOI: 10.1038/Sj.Embor.7401071  0.417
2007 Wehkamp J, Wang G, Kübler I, Nuding S, Gregorieff A, Schnabel A, Kays RJ, Fellermann K, Burk O, Schwab M, Clevers H, Bevins CL, Stange EF. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. Journal of Immunology (Baltimore, Md. : 1950). 179: 3109-18. PMID 17709525 DOI: 10.4049/Jimmunol.179.5.3109  0.351
2007 Brugmann SA, Goodnough LH, Gregorieff A, Leucht P, ten Berge D, Fuerer C, Clevers H, Nusse R, Helms JA. Wnt signaling mediates regional specification in the vertebrate face. Development (Cambridge, England). 134: 3283-95. PMID 17699607 DOI: 10.1242/Dev.005132  0.303
2007 Mori-Akiyama Y, van den Born M, van Es JH, Hamilton SR, Adams HP, Zhang J, Clevers H, de Crombrugghe B. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology. 133: 539-46. PMID 17681175 DOI: 10.1053/J.Gastro.2007.05.020  0.469
2007 Gregorieff A, Clevers H. Giving APCmin tumours a SPARC. Gut. 56: 1341-3. PMID 17446305 DOI: 10.1136/Gut.2007.122135  0.347
2007 Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR. Myc deletion rescues Apc deficiency in the small intestine Nature. 446: 676-679. PMID 17377531 DOI: 10.1038/Nature05674  0.422
2007 Malaterre J, Carpinelli M, Ernst M, Alexander W, Cooke M, Sutton S, Dworkin S, Heath JK, Frampton J, McArthur G, Clevers H, Hilton D, Mantamadiotis T, Ramsay RG. c-Myb is required for progenitor cell homeostasis in colonic crypts. Proceedings of the National Academy of Sciences of the United States of America. 104: 3829-34. PMID 17360438 DOI: 10.1073/Pnas.0610055104  0.429
2007 Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (Cambridge, England). 134: 535-44. PMID 17215306 DOI: 10.1242/Dev.02733  0.382
2007 Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nature Reviews. Drug Discovery. 5: 997-1014. PMID 17139285 DOI: 10.1038/Nrd2154  0.356
2007 de Lau W, Barker N, Clevers H. WNT signaling in the normal intestine and colorectal cancer. Frontiers in Bioscience : a Journal and Virtual Library. 12: 471-91. PMID 17127311 DOI: 10.2741/2076  0.38
2006 Van der Flier LG, Sabates-Bellver J, Oving I, Haegebarth A, De Palo M, Anti M, Van Gijn ME, Suijkerbuijk S, Van de Wetering M, Marra G, Clevers H. The Intestinal Wnt/TCF Signature. Gastroenterology. 132: 628-32. PMID 17320548 DOI: 10.1053/J.Gastro.2006.08.039  0.405
2006 Clevers H. Wnt/beta-catenin signaling in development and disease. Cell. 127: 469-80. PMID 17081971 DOI: 10.1016/J.Cell.2006.10.018  0.381
2006 Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, Moreno De Alboran I, Clevers H, Clarke AR. Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc Molecular and Cellular Biology. 26: 8418-8426. PMID 16954380 DOI: 10.1128/Mcb.00821-06  0.402
2006 Markiewicz E, Tilgner K, Barker N, van de Wetering M, Clevers H, Dorobek M, Hausmanowa-Petrusewicz I, Ramaekers FC, Broers JL, Blankesteijn WM, Salpingidou G, Wilson RG, Ellis JA, Hutchison CJ. The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus. The Embo Journal. 25: 3275-85. PMID 16858403 DOI: 10.1038/Sj.Emboj.7601230  0.301
2006 Radtke F, Clevers H, Riccio O. From gut homeostasis to cancer. Current Molecular Medicine. 6: 275-89. PMID 16712475 DOI: 10.2174/156652406776894527  0.458
2006 Clevers H. Colon cancer--understanding how NSAIDs work. The New England Journal of Medicine. 354: 761-3. PMID 16481647 DOI: 10.1056/Nejmcibr055457  0.309
2006 Giles RH, Lolkema MP, Snijckers CM, Belderbos M, van der Groep P, Mans DA, van Beest M, van Noort M, Goldschmeding R, van Diest PJ, Clevers H, Voest EE. Interplay between VHL/HIF1alpha and Wnt/beta-catenin pathways during colorectal tumorigenesis. Oncogene. 25: 3065-70. PMID 16407833 DOI: 10.1038/Sj.Onc.1209330  0.398
2006 Clevers H, Batlle E. EphB/EphrinB receptors and Wnt signaling in colorectal cancer. Cancer Research. 66: 2-5. PMID 16397205 DOI: 10.1158/0008-5472.Can-05-3849  0.384
2006 Jansen M, de Leng WW, Baas AF, Myoshi H, Mathus-Vliegen L, Taketo MM, Clevers H, Giardiello FM, Offerhaus GJ. Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis. Gut. 55: 1-5. PMID 16344569 DOI: 10.1136/Gut.2005.069062  0.303
2005 Malliri A, Rygiel TP, van der Kammen RA, Song JY, Engers R, Hurlstone AF, Clevers H, Collard JG. The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development. The Journal of Biological Chemistry. 281: 543-8. PMID 16249175 DOI: 10.1074/Jbc.M507582200  0.391
2005 van Es JH, Clevers H. Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease. Trends in Molecular Medicine. 11: 496-502. PMID 16214417 DOI: 10.1016/J.Molmed.2005.09.008  0.344
2005 Clevers H. Stem cells, asymmetric division and cancer. Nature Genetics. 37: 1027-8. PMID 16195718 DOI: 10.1038/Ng1005-1027  0.441
2005 Batlle E, Bacani J, Begthel H, Jonkheer S, Jonkeer S, Gregorieff A, van de Born M, Malats N, Sancho E, Boon E, Pawson T, Gallinger S, Pals S, Clevers H. EphB receptor activity suppresses colorectal cancer progression. Nature. 435: 1126-30. PMID 15973414 DOI: 10.1038/Nature03626  0.395
2005 van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 435: 959-63. PMID 15959515 DOI: 10.1038/Nature03659  0.479
2005 Pinto D, Clevers H. Wnt control of stem cells and differentiation in the intestinal epithelium. Experimental Cell Research. 306: 357-63. PMID 15925592 DOI: 10.1016/J.Yexcr.2005.02.022  0.504
2005 Glass DA, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Developmental Cell. 8: 751-64. PMID 15866165 DOI: 10.1016/J.Devcel.2005.02.017  0.316
2005 Gregorieff A, Clevers H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes & Development. 19: 877-90. PMID 15833914 DOI: 10.1101/Gad.1295405  0.411
2005 Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 434: 843-50. PMID 15829953 DOI: 10.1038/Nature03319  0.475
2005 Forcet C, Etienne-Manneville S, Gaude H, Fournier L, Debilly S, Salmi M, Baas A, Olschwang S, Clevers H, Billaud M. Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Human Molecular Genetics. 14: 1283-92. PMID 15800014 DOI: 10.1093/Hmg/Ddi139  0.353
2005 Radtke F, Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science (New York, N.Y.). 307: 1904-9. PMID 15790842 DOI: 10.1126/Science.1104815  0.368
2005 van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, van den Born M, Begthel H, Brabletz T, Taketo MM, Clevers H. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nature Cell Biology. 7: 381-6. PMID 15778706 DOI: 10.1038/Ncb1240  0.5
2005 Riedl JA, Brandt DT, Batlle E, Price LS, Clevers H, Bos JL. Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. The Biochemical Journal. 389: 465-9. PMID 15725075 DOI: 10.1042/Bj20050048  0.414
2005 Pinto D, Clevers H. Wnt, stem cells and cancer in the intestine. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 97: 185-96. PMID 15715524 DOI: 10.1042/Bc20040094  0.477
2005 Laoukili J, Kooistra MR, Brás A, Kauw J, Kerkhoven RM, Morrison A, Clevers H, Medema RH. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nature Cell Biology. 7: 126-36. PMID 15654331 DOI: 10.1038/Ncb1217  0.315
2005 Sancho E, Batlle E, Clevers H. Signaling pathways in intestinal development and cancer. Annual Review of Cell and Developmental Biology. 20: 695-723. PMID 15473857 DOI: 10.1146/Annurev.Cellbio.20.010403.092805  0.442
2005 Gregorieff A, Pinto D, Begthel H, Destrée O, Kielman M, Clevers H. Expression Pattern of Wnt Signaling Components in the Adult Intestine Gastroenterology. 129: 626-638. DOI: 10.1053/J.Gastro.2005.06.007  0.446
2004 Clevers H. At the crossroads of inflammation and cancer. Cell. 118: 671-4. PMID 15369667 DOI: 10.1016/J.Cell.2004.09.005  0.309
2004 Blache P, van de Wetering M, Duluc I, Domon C, Berta P, Freund JN, Clevers H, Jay P. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. The Journal of Cell Biology. 166: 37-47. PMID 15240568 DOI: 10.1083/Jcb.200311021  0.453
2004 Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes & Development. 18: 1385-90. PMID 15198980 DOI: 10.1101/Gad.287404  0.409
2004 Baas AF, Smit L, Clevers H. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends in Cell Biology. 14: 312-9. PMID 15183188 DOI: 10.1016/J.Tcb.2004.04.001  0.401
2004 Le NH, van der Bent P, Huls G, van de Wetering M, Loghman-Adham M, Ong AC, Calvet JP, Clevers H, Breuning MH, van Dam H, Peters DJ. Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected. The Journal of Biological Chemistry. 279: 27472-81. PMID 15087466 DOI: 10.1074/Jbc.M312183200  0.356
2004 Derksen PW, Tjin E, Meijer HP, Klok MD, MacGillavry HD, van Oers MH, Lokhorst HM, Bloem AC, Clevers H, Nusse R, van der Neut R, Spaargaren M, Pals ST. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 6122-7. PMID 15067127 DOI: 10.1073/Pnas.0305855101  0.424
2004 Gregorieff A, Grosschedl R, Clevers H. Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. The Embo Journal. 23: 1825-33. PMID 15057272 DOI: 10.1038/Sj.Emboj.7600191  0.376
2004 Haramis AP, Begthel H, van den Born M, van Es J, Jonkheer S, Offerhaus GJ, Clevers H. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (New York, N.Y.). 303: 1684-6. PMID 15017003 DOI: 10.1126/Science.1093587  0.4
2004 Clevers H. Wnt breakers in colon cancer. Cancer Cell. 5: 5-6. PMID 14749120 DOI: 10.1016/S1535-6108(03)00339-8  0.368
2004 Sancho E, Batlle E, Clevers H. Live and let die in the intestinal epithelium. Current Opinion in Cell Biology. 15: 763-70. PMID 14644203 DOI: 10.1016/J.Ceb.2003.10.012  0.462
2004 Verbrugge A, Ruiter Td Td, Clevers H, Meyaard L. Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment. International Immunology. 15: 1349-58. PMID 14565933 DOI: 10.1093/Intimm/Dxg134  0.331
2004 van de Wetering M, Oving I, Muncan V, Pon Fong MT, Brantjes H, van Leenen D, Holstege FC, Brummelkamp TR, Agami R, Clevers H. Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. Embo Reports. 4: 609-15. PMID 12776180 DOI: 10.1038/Sj.Embor.Embor865  0.367
2004 Sancho E, Batlle E, Clevers H. Live and let die in the intestinal epithelium [Curr. Opin. Cell Biol. 15 (2003) 763] Current Opinion in Cell Biology. 16: 113. DOI: 10.1016/J.Ceb.2003.12.001  0.394
2003 Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, Taketo MM, Behringer RR, Shen MM, Birchmeier W. Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development (Cambridge, England). 130: 6283-94. PMID 14623818 DOI: 10.1242/Dev.00859  0.335
2003 Hurlstone AF, Haramis AP, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RH, Clevers H. The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature. 425: 633-7. PMID 14534590 DOI: 10.1038/Nature02028  0.358
2003 Clevers H. Thymocyte development: drama without Brahma. Immunity. 19: 157-8. PMID 12932348 DOI: 10.1016/S1074-7613(03)00213-9  0.302
2003 Brinkmeier ML, Potok MA, Cha KB, Gridley T, Stifani S, Meeldijk J, Clevers H, Camper SA. TCF and Groucho-related genes influence pituitary growth and development. Molecular Endocrinology (Baltimore, Md.). 17: 2152-61. PMID 12907761 DOI: 10.1210/Me.2003-0225  0.343
2003 Pinto D, Gregorieff A, Begthel H, Clevers H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes & Development. 17: 1709-13. PMID 12865297 DOI: 10.1101/Gad.267103  0.44
2003 Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Et Biophysica Acta. 1653: 1-24. PMID 12781368 DOI: 10.1016/S0304-419X(03)00005-2  0.42
2003 Held W, Clevers H, Grosschedl R. Redundant functions of TCF-1 and LEF-1 during T and NK cell development, but unique role of TCF-1 for Ly49 NK cell receptor acquisition. European Journal of Immunology. 33: 1393-8. PMID 12731066 DOI: 10.1002/Eji.200323840  0.388
2003 Bienz M, Clevers H. Armadillo/beta-catenin signals in the nucleus--proof beyond a reasonable doubt? Nature Cell Biology. 5: 179-82. PMID 12646868 DOI: 10.1038/Ncb0303-179  0.312
2003 Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, van Noort M, Hui CC, Clevers H, Dotto GP, Radtke F. Notch1 functions as a tumor suppressor in mouse skin. Nature Genetics. 33: 416-21. PMID 12590261 DOI: 10.1038/Ng1099  0.371
2003 van Es JH, Barker N, Clevers H. You Wnt some, you lose some: oncogenes in the Wnt signaling pathway. Current Opinion in Genetics & Development. 13: 28-33. PMID 12573432 DOI: 10.1016/S0959-437X(02)00012-6  0.362
2003 Clevers H. Inflating cell numbers by Wnt. Molecular Cell. 10: 1260-1. PMID 12504000 DOI: 10.1016/S1097-2765(02)00801-8  0.428
2002 Batlle E, Henderson JT, Beghtel H, van den Born MM, Sancho E, Huls G, Meeldijk J, Robertson J, van de Wetering M, Pawson T, Clevers H. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell. 111: 251-63. PMID 12408869 DOI: 10.1016/S0092-8674(02)01015-2  0.449
2002 van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, van der Horn K, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M, Moerer P, van den Born M, Soete G, Pals S, ... ... Clevers H, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 111: 241-50. PMID 12408868 DOI: 10.1016/S0092-8674(02)01014-0  0.401
2002 Gallagher RC, Hay T, Meniel V, Naughton C, Anderson TJ, Shibata H, Ito M, Clevers H, Noda T, Sansom OJ, Mason JO, Clarke AR. Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene. 21: 6446-57. PMID 12226748 DOI: 10.1038/Sj.Onc.1205892  0.351
2002 Cheon SS, Cheah AY, Turley S, Nadesan P, Poon R, Clevers H, Alman BA. beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proceedings of the National Academy of Sciences of the United States of America. 99: 6973-8. PMID 11983872 DOI: 10.1073/Pnas.102657399  0.351
2002 van de Wetering M, de Lau W, Clevers H. WNT signaling and lymphocyte development. Cell. S13-9. PMID 11983149 DOI: 10.1016/S0092-8674(02)00709-2  0.346
2002 van Noort M, Clevers H. TCF transcription factors, mediators of Wnt-signaling in development and cancer. Developmental Biology. 244: 1-8. PMID 11900454 DOI: 10.1006/Dbio.2001.0566  0.336
2002 Fodde R, Smits R, Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nature Reviews. Cancer. 1: 55-67. PMID 11900252 DOI: 10.1038/35094067  0.351
2002 van Noort M, Meeldijk J, van der Zee R, Destree O, Clevers H. Wnt signaling controls the phosphorylation status of beta-catenin. The Journal of Biological Chemistry. 277: 17901-5. PMID 11834740 DOI: 10.1074/Jbc.M111635200  0.31
2002 Lustig B, Jerchow B, Sachs M, Weiler S, Pietsch T, Karsten U, van de Wetering M, Clevers H, Schlag PM, Birchmeier W, Behrens J. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Molecular and Cellular Biology. 22: 1184-93. PMID 11809809 DOI: 10.1128/Mcb.22.4.1184-1193.2002  0.353
2002 Barker N, Clevers H. Tumor environment: a potent driving force in colorectal cancer? Trends in Molecular Medicine. 7: 535-7. PMID 11733201 DOI: 10.1016/S1471-4914(01)02215-8  0.311
2001 Barker N, Hurlstone A, Musisi H, Miles A, Bienz M, Clevers H. The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. The Embo Journal. 20: 4935-43. PMID 11532957 DOI: 10.1093/Emboj/20.17.4935  0.346
2001 Ioannidis V, Beermann F, Clevers H, Held W. The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival. Nature Immunology. 2: 691-7. PMID 11477404 DOI: 10.1038/90623  0.33
2001 Meyaard L, van der Vuurst de Vries AR, de Ruiter T, Lanier LL, Phillips JH, Clevers H. The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). The Journal of Experimental Medicine. 194: 107-12. PMID 11435477 DOI: 10.1084/Jem.194.1.107  0.321
2001 de Lau W, Clevers H. LEF1 turns over a new leaf. Nature Genetics. 28: 3-4. PMID 11326260 DOI: 10.1038/Ng0501-3  0.422
2001 Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, Gaspar C, van Es JH, Breukel C, Wiegant J, Giles RH, Clevers H. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nature Cell Biology. 3: 433-8. PMID 11283620 DOI: 10.1038/35070129  0.353
2001 Brantjes H, Roose J, van De Wetering M, Clevers H. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Research. 29: 1410-9. PMID 11266540 DOI: 10.1093/Nar/29.7.1410  0.325
2001 Staal FJ, Meeldijk J, Moerer P, Jay P, van de Weerdt BC, Vainio S, Nolan GP, Clevers H. Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. European Journal of Immunology. 31: 285-93. PMID 11265645 DOI: 10.1002/1521-4141(200101)31:1<285::Aid-Immu285>3.0.Co;2-D  0.412
2001 Barker N, Clevers H. Catenins, Wnt signaling and cancer. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 22: 961-5. PMID 11056471 DOI: 10.1002/1521-1878(200011)22:11<961::Aid-Bies1>3.0.Co;2-T  0.33
2000 Lawrence N, Dearden P, Hartley D, Roose J, Clevers H, Arias AM. dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila. The International Journal of Developmental Biology. 44: 749-56. PMID 11128568 DOI: 10.1387/Ijdb.11128568  0.336
2000 Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell. 103: 311-20. PMID 11057903 DOI: 10.1016/S0092-8674(00)00122-7  0.302
2000 Clevers H. Armadillo takes the APC shuttle. Nature Cell Biology. 2: E177-8. PMID 11025675 DOI: 10.1038/35036424  0.31
2000 Molenaar M, Brian E, Roose J, Clevers H, Destrée O. Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. Mechanisms of Development. 91: 311-5. PMID 10704855 DOI: 10.1016/S0925-4773(99)00259-2  0.301
2000 Clevers H. Axin and hepatocellular carcinomas. Nature Genetics. 24: 206-8. PMID 10700164 DOI: 10.1038/73396  0.328
2000 Barker N, Morin PJ, Clevers H. The Yin-Yang of TCF/β-catenin signaling Advances in Cancer Research. 77: 1-24. PMID 10549354 DOI: 10.1016/S0065-230X(08)60783-6  0.387
1999 Held W, Kunz B, Lowin-Kropf B, van de Wetering M, Clevers H. Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1. Immunity. 11: 433-42. PMID 10549625 DOI: 10.1016/S1074-7613(00)80118-1  0.358
1999 van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L. Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling. European Journal of Immunology. 29: 3160-7. PMID 10540327 DOI: 10.1002/(Sici)1521-4141(199910)29:10<3160::Aid-Immu3160>3.0.Co;2-S  0.68
1999 Roose J, Clevers H. TCF transcription factors: molecular switches in carcinogenesis. Biochimica Et Biophysica Acta. 1424: M23-37. PMID 10528152 DOI: 10.1016/S0304-419X(99)00026-8  0.348
1999 Roose J, Huls G, Beest Mv, Moerer P, Horn Kvd, Goldschmeding R, Logtenberg T, Clevers H. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science. 285: 1923-1926. PMID 10489374 DOI: 10.1126/Science.285.5435.1923  0.675
1999 Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, Matsumoto K. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature. 399: 798-802. PMID 10391247 DOI: 10.1038/21674  0.342
1999 Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H. The Sox-13 gene: structure, promoter characterization, and chromosomal localization. Genomics. 57: 301-5. PMID 10198172 DOI: 10.1006/Geno.1999.5779  0.303
1999 Galceran J, Fariñas I, Depew MJ, Clevers H, Grosschedl R. Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes & Development. 13: 709-17. PMID 10090727 DOI: 10.1101/Gad.13.6.709  0.357
1999 Wielenga VJ, Smits R, Korinek V, Smit L, Kielman M, Fodde R, Clevers H, Pals ST. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. The American Journal of Pathology. 154: 515-23. PMID 10027409 DOI: 10.1016/S0002-9440(10)65297-2  0.331
1999 van Es JH, Kirkpatrick C, van de Wetering M, Molenaar M, Miles A, Kuipers J, Destrée O, Peifer M, Clevers H. Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Current Biology : Cb. 9: 105-8. PMID 10021369 DOI: 10.1016/S0960-9822(99)80024-4  0.376
1999 Barker N, Huls G, Korinek V, Clevers H. Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium. The American Journal of Pathology. 154: 29-35. PMID 9916915 DOI: 10.1016/S0002-9440(10)65247-9  0.368
1999 Korver W, Schilham MW, Moerer P, van den Hoff MJ, Dam K, Lamers WH, Medema RH, Clevers H. Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident. Current Biology : Cb. 8: 1327-30. PMID 9843684 DOI: 10.1016/S0960-9822(07)00563-5  0.335
1999 Molenaar M, Roose J, Peterson J, Venanzi S, Clevers H, Destrée O. Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development. Mechanisms of Development. 75: 151-4. PMID 9739131 DOI: 10.1016/S0925-4773(98)00085-9  0.316
1998 Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, van de Wetering M, Destrée O, Clevers H. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature. 395: 608-12. PMID 9783587 DOI: 10.1038/26989  0.313
1998 Cavallo RA, Cox RT, Moline MM, Roose J, Polevoy GA, Clevers H, Peifer M, Bejsovec A. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 395: 604-8. PMID 9783586 DOI: 10.1038/26982  0.365
1998 Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters PJ, Clevers H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nature Genetics. 19: 379-83. PMID 9697701 DOI: 10.1038/1270  0.477
1998 Schilham MW, Clevers H. HMG box containing transcription factors in lymphocyte differentiation. Seminars in Immunology. 10: 127-32. PMID 9618758 DOI: 10.1006/Smim.1998.0114  0.369
1998 Clevers H, Ferrier P. Transcriptional control during T-cell development. Current Opinion in Immunology. 10: 166-71. PMID 9602305 DOI: 10.1016/S0952-7915(98)80245-8  0.384
1998 de Lau WB, Kuipers J, Peters PJ, Lokhorst HM, Clevers H, Bast BJ. Putative myeloma precursor cells expressing 2,6 sialic acid-modified antigens actually belong to the erythroid lineage. Leukemia Research. 22: 163-73. PMID 9593473 DOI: 10.1016/S0145-2126(97)00154-9  0.368
1998 Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G, Markman M, Lamers W, Destree O, Clevers H. Two members of the Tcf family implicated in Wnt/β-catenin signaling during embryogenesis in the mouse Molecular and Cellular Biology. 18: 1248-1256. PMID 9488439 DOI: 10.1128/Mcb.18.3.1248  0.347
1998 Okamura RM, Sigvardsson M, Galceran J, Verbeek S, Clevers H, Grosschedl R. Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity. 8: 11-20. PMID 9462507 DOI: 10.1016/S1074-7613(00)80454-9  0.379
1998 Korver W, Roose J, Wilson A, Clevers H. The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes. Immunobiology. 198: 157-61. PMID 9442387 DOI: 10.1016/S0171-2985(97)80036-8  0.348
1998 Clevers H, van de Wetering M. TCF/LEF factor earn their wings. Trends in Genetics : Tig. 13: 485-9. PMID 9433138 DOI: 10.1016/S0168-9525(97)01305-X  0.328
1998 Roose J, Korver W, Oving E, Wilson A, Wagenaar G, Markman M, Lamers W, Clevers H. High expression of the HMG box factor sox-13 in arterial walls during embryonic development. Nucleic Acids Research. 26: 469-76. PMID 9421502 DOI: 10.1093/Nar/26.2.469  0.32
1997 Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics. 46: 435-42. PMID 9441747 DOI: 10.1006/Geno.1997.5065  0.338
1997 Ya J, Schilham MW, Clevers H, Moorman AF, Lamers WH. Animal models of congenital defects in the ventriculoarterial connection of the heart. Journal of Molecular Medicine (Berlin, Germany). 75: 551-66. PMID 9297623 DOI: 10.1007/S001090050140  0.31
1997 Mayer K, Hieronymus T, Castrop J, Clevers H, Ballhausen WG. Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells. International Journal of Cancer. 72: 625-30. PMID 9259402 DOI: 10.1002/(Sici)1097-0215(19970807)72:4<625::Aid-Ijc13>3.0.Co;2-A  0.417
1997 Kjærulff S, Dooijes D, Clevers H, Nielsen O. Cell differentiation by interaction of two HMG‐box proteins: Mat1‐Mc activates M cell‐specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites The Embo Journal. 16: 4021-4033. PMID 9233811 DOI: 10.1093/Emboj/16.13.4021  0.313
1997 Dooijes D, Clevers H. Control of gene expression during lymphoid development: targeted gene disruption provides new clues. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 105: 337-44. PMID 9201234 DOI: 10.1111/J.1699-0463.1997.Tb00579.X  0.304
1997 van de Wetering M, Cavallo R, Dooijes D, van Beest M, van Es J, Loureiro J, Ypma A, Hursh D, Jones T, Bejsovec A, Peifer M, Mortin M, Clevers H. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell. 88: 789-99. PMID 9118222 DOI: 10.1016/S0092-8674(00)81925-X  0.346
1997 Korver W, Roose J, Clevers H. The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Research. 25: 1715-9. PMID 9108152 DOI: 10.1093/Nar/25.9.1715  0.368
1997 Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC Science. 275: 1787-1790. PMID 9065402 DOI: 10.1126/Science.275.5307.1787  0.339
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