| Year |
Citation |
Score |
| 2023 |
Balla H, Borsodi K, Őrsy P, Horváth B, Molnár PJ, Lénárt Á, Kosztelnik M, Ruisanchez É, Wess J, Offermanns S, Nyirády P, Benyó Z. Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions. American Journal of Physiology. Renal Physiology. PMID 37675459 DOI: 10.1152/ajprenal.00261.2022 |
0.448 |
|
| 2023 |
Zheng F, Wess J, Alzheimer C. Long-Term-But Not Short-Term-Plasticity at the Mossy Fiber-CA3 Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3 Muscarinic Acetylcholine Receptor Double Knockout Mice. Cells. 12. PMID 37508553 DOI: 10.3390/cells12141890 |
0.43 |
|
| 2023 |
Wess J. The third intracellular loop of GPCRs: size matters. Trends in Pharmacological Sciences. PMID 37208206 DOI: 10.1016/j.tips.2023.05.001 |
0.348 |
|
| 2022 |
Meister J, Bone DBJ, Knudsen JR, Barella LF, Velenosi TJ, Akhmedov D, Lee RJ, Cohen AH, Gavrilova O, Cui Y, Karsenty G, Chen M, Weinstein LS, Kleinert M, Berdeaux R, ... ... Wess J, et al. Clenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells. Nature Communications. 13: 22. PMID 35013148 DOI: 10.1038/s41467-021-27540-w |
0.308 |
|
| 2021 |
Wess J. In Vivo Metabolic Roles of G Proteins of the Gi Family Studied with Novel Mouse Models. Endocrinology. PMID 34871353 DOI: 10.1210/endocr/bqab245 |
0.327 |
|
| 2020 |
Wang L, Zhu L, Meister J, Bone DBJ, Pydi SP, Rossi M, Wess J. Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs. Annual Review of Pharmacology and Toxicology. PMID 32746768 DOI: 10.1146/Annurev-Pharmtox-030220-121042 |
0.405 |
|
| 2020 |
Pydi SP, Jain S, Barella LF, Zhu L, Sakamoto W, Meister J, Wang L, Lu H, Cui Y, Gavrilova O, Wess J. β-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia. Science Advances. 6: eaba1733. PMID 32548266 DOI: 10.1126/Sciadv.Aba1733 |
0.329 |
|
| 2020 |
Wang L, Pydi SP, Zhu L, Barella LF, Cui Y, Gavrilova O, Bence KK, Vernochet C, Wess J. Adipocyte G signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity. Nature Communications. 11: 2995. PMID 32532984 DOI: 10.1038/S41467-020-16756-X |
0.345 |
|
| 2020 |
Zhu L, Rossi M, Doliba NM, Wess J. Beta-cell M muscarinic acetylcholine receptors as potential targets for novel antidiabetic drugs. International Immunopharmacology. 81: 106267. PMID 32044662 DOI: 10.1016/J.Intimp.2020.106267 |
0.379 |
|
| 2020 |
Dattaroy D, Barella LF, Pydi SP, Cui Y, Kaestner KH, Wess J. 2129-P: Glucagon Secretion from Pancreatic Islets Is Regulated by Beta-Arrestin-1 Diabetes. 69. DOI: 10.2337/Db20-2129-P |
0.359 |
|
| 2020 |
Pydi SP, Jain S, Barella LF, Meister J, Wang L, Cui Y, Gavrilova O, Wess J. 1694-P: Beta-Arrestin 1 Suppresses Myogenic Reprogramming of Brown Fat to Maintain Euglycemia Diabetes. 69. DOI: 10.2337/Db20-1694-P |
0.382 |
|
| 2019 |
Meister J, Bone DBJ, Godlewski G, Liu Z, Lee RJ, Vishnivetskiy SA, Gurevich VV, Springer D, Kunos G, Wess J. Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice. Plos Genetics. 15: e1008424. PMID 31622341 DOI: 10.1371/Journal.Pgen.1008424 |
0.369 |
|
| 2019 |
Burczyk MS, Burkhalter MD, Tena TC, Grisanti LA, Kauk M, Matysik S, Donow C, Kustermann M, Rothe M, Cui Y, Raad F, Laue S, Moretti A, Zimmermann WH, Wess J, et al. Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish. Jci Insight. 4. PMID 31619590 DOI: 10.1172/Jci.Insight.121971 |
0.456 |
|
| 2019 |
Trivedi G, Inoue D, Chen C, Bitner L, Chung YR, Taylor J, Gönen M, Wess J, Abdel-Wahab O, Zhang L. Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors. Science Translational Medicine. 11. PMID 31554738 DOI: 10.1126/Scitranslmed.Aaw3781 |
0.406 |
|
| 2019 |
Zhu L, Rossi M, Cohen A, Pham J, Zheng H, Dattaroy D, Mukaibo T, Melvin JE, Langel JL, Hattar S, Matschinsky FM, Appella DH, Doliba NM, Wess J. Allosteric modulation of β-cell M muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 31451647 DOI: 10.1073/Pnas.1904943116 |
0.394 |
|
| 2019 |
Wang L, Pydi SP, Cui Y, Zhu L, Meister J, Gavrilova O, Berdeaux R, Fortin JP, Bence KK, Vernochet C, Wess J. Selective activation of G signaling in adipocytes causes striking metabolic improvements in mice. Molecular Metabolism. PMID 31272886 DOI: 10.1016/J.Molmet.2019.06.018 |
0.322 |
|
| 2019 |
Pydi SP, Jain S, Tung W, Cui Y, Zhu L, Sakamoto W, Jain S, Abel BS, Skarulis MC, Liu J, Huynh T, Pacak K, Caron MG, Gavrilova O, Finkel T, ... Wess J, et al. Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis. Nature Communications. 10: 2936. PMID 31270323 DOI: 10.1038/S41467-019-11003-4 |
0.351 |
|
| 2019 |
Barella LF, Rossi M, Zhu L, Cui Y, Mei FC, Cheng X, Chen W, Gurevich VV, Wess J. β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion. The Journal of Clinical Investigation. 130. PMID 31184597 DOI: 10.1172/Jci126309 |
0.319 |
|
| 2019 |
Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J. Intra-islet glucagon signaling is critical for maintaining glucose homeostasis. Jci Insight. 5. PMID 31012868 DOI: 10.1172/Jci.Insight.127994 |
0.379 |
|
| 2019 |
Bone DBJ, Meister J, Knudsen JR, Dattaroy D, Cohen A, Lee R, Lu H, Metzger D, Jensen TE, Wess J. Skeletal Muscle-Specific Activation of G Signaling Maintains Glucose Homeostasis. Diabetes. PMID 30936140 DOI: 10.2337/Db18-0796 |
0.37 |
|
| 2019 |
WANG L, PYDI SP, ZHU L, JAIN S, CUI Y, GAVRILOVA O, WESS J. 1781-P: Adipocyte GI Signaling Regulates Whole-Body Glucose Homeostasis and Insulin Sensitivity Diabetes. 68: 1781-P. DOI: 10.2337/Db19-1781-P |
0.354 |
|
| 2019 |
Vincent SG, Bone D, Wess J, Fisher JT. Late Breaking Abstract - Activation of a murine skeletal muscle M3 muscarinic Designer Receptor Exclusively Activated by Designer Drug (DREADD) has cardiopulmonary consequences European Respiratory Journal. 54. DOI: 10.1183/13993003.Congress-2019.Pa2028 |
0.455 |
|
| 2018 |
Romberg C, Bartko S, Wess J, Saksida LM, Bussey TJ. Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice. Psychopharmacology. PMID 30327842 DOI: 10.1007/S00213-018-5065-7 |
0.52 |
|
| 2018 |
Kaiser E, Tian Q, Wagner M, Barth M, Xian W, Schroeder L, Ruppenthal S, Kaestner L, Boehm U, Wartenberg P, Lu H, McMillin SM, Bone DB, Wess J, Lipp P. DREADD technology reveals major impact of Gq signaling on cardiac electrophysiology. Cardiovascular Research. PMID 30321287 DOI: 10.1093/Cvr/Cvy251 |
0.348 |
|
| 2018 |
Welliver RR, Polanco JJ, Seidman RA, Sinha AK, O'Bara MA, Khaku ZM, Santiago González DA, Nishiyama A, Wess J, Feltri ML, Paez PM, Sim FJ. Muscarinic receptor MR signaling prevents efficient remyelination by human and mouse oligodendrocyte progenitor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29959237 DOI: 10.1523/Jneurosci.1862-17.2018 |
0.482 |
|
| 2018 |
Klawonn AM, Wilhelms DB, Lindström SH, Singh AK, Jaarola M, Wess J, Fritz M, Engblom D. Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity. Frontiers in Molecular Neuroscience. 11: 139. PMID 29740282 DOI: 10.3389/fnmol.2018.00139 |
0.335 |
|
| 2018 |
Deckmann K, Rafiq A, Erdmann C, Illig C, Durschnabel M, Wess J, Weidner W, Bschleipfer T, Kummer W. Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201700582R. PMID 29401598 DOI: 10.1096/Fj.201700582R |
0.548 |
|
| 2018 |
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, ... ... Wess J, et al. Lack of beta-arrestin signaling in the absence of active G proteins. Nature Communications. 9: 341. PMID 29362459 DOI: 10.1038/S41467-017-02661-3 |
0.354 |
|
| 2018 |
Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, ... ... Wess J, et al. Hepatic Gi signaling regulates whole-body glucose homeostasis. The Journal of Clinical Investigation. PMID 29337301 DOI: 10.1172/Jci94505 |
0.323 |
|
| 2018 |
PYDI SP, WESS J. Adipocyte-Selective Deletion of ß-Arrestin-1 in Mice Causes Adiposity, Impaired Glucose Tolerance, and Reduced Insulin Sensitivity Diabetes. 67: 2034-P. DOI: 10.2337/Db18-2034-P |
0.363 |
|
| 2018 |
JAIN S, WESS J, JACOBSON KA. Polymorphic Role of P2Y6Receptor in Insulin Sensitive Organs—Adipose Tissue and Skeletal Muscle Diabetes. 67: 1769-P. DOI: 10.2337/Db18-1769-P |
0.353 |
|
| 2018 |
ZHU L, WESS J. A Positive Allosteric Modulator Enhances the Ability of Beta Cell M3 Muscarinic Receptors to Simulate Insulin Secretion In Vitro and In Vivo Diabetes. 67: 1767-P. DOI: 10.2337/Db18-1767-P |
0.442 |
|
| 2017 |
Moehle MS, Pancani T, Byun N, Yohn SE, Wilson GH, Dickerson JW, Remke DH, Xiang Z, Niswender CM, Wess J, Jones CK, Lindsley CW, Rook JM, Conn PJ. Cholinergic Projections to the Substantia Nigra Pars Reticulata Inhibit Dopamine Modulation of Basal Ganglia through the M4 Muscarinic Receptor. Neuron. 96: 1358-1372.e4. PMID 29268098 DOI: 10.1016/J.Neuron.2017.12.008 |
0.455 |
|
| 2017 |
Gould RW, Grannan MD, Gunter BW, Ball J, Bubser M, Bridges TM, Wess J, Wood MW, Brandon NJ, Duggan ME, Niswender CM, Lindsley CW, Conn PJ, Jones CK. Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154. Neuropharmacology. PMID 28729220 DOI: 10.1016/J.Neuropharm.2017.07.013 |
0.426 |
|
| 2017 |
Zhu L, Rossi M, Cui Y, Lee RJ, Sakamoto W, Perry NA, Urs NM, Caron MG, Gurevich VV, Godlewski G, Kunos G, Chen M, Chen W, Wess J. Hepatic β-arrestin 2 is essential for maintaining euglycemia. The Journal of Clinical Investigation. PMID 28650340 DOI: 10.1172/Jci92913 |
0.31 |
|
| 2017 |
Akhmedov D, Mendoza-Rodriguez MG, Rajendran K, Rossi M, Wess J, Berdeaux R. Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling. Molecular and Cellular Biology. 37. PMID 28167604 DOI: 10.1128/Mcb.00584-16 |
0.398 |
|
| 2017 |
Calcutt NA, Smith DR, Frizzi K, Sabbir MG, Chowdhury SK, Mixcoatl-Zecuatl T, Saleh A, Muttalib N, Van der Ploeg R, Ochoa J, Gopaul A, Tessler L, Wess J, Jolivalt CG, Fernyhough P. Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy. The Journal of Clinical Investigation. PMID 28094765 DOI: 10.1172/Jci88321 |
0.376 |
|
| 2016 |
Bradley SJ, Bourgognon JM, Sanger HE, Verity N, Mogg AJ, White DJ, Butcher AJ, Moreno JA, Molloy C, Macedo-Hatch T, Edwards JM, Wess J, Pawlak R, Read DJ, Sexton PM, et al. M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss. The Journal of Clinical Investigation. PMID 27991860 DOI: 10.1172/Jci87526 |
0.448 |
|
| 2016 |
Leaderbrand K, Chen HJ, Corcoran KA, Guedea AL, Jovasevic V, Wess J, Radulovic J. Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory. Learning & Memory (Cold Spring Harbor, N.Y.). 23: 631-638. PMID 27918283 DOI: 10.1101/Lm.043133.116 |
0.397 |
|
| 2016 |
Foster DJ, Wilson JM, Remke DH, Mahmood MS, Uddin MJ, Wess J, Patel S, Marnett LJ, Niswender CM, Jones CK, Xiang Z, Lindsley CW, Rook JM, Conn PJ. Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release. Neuron. PMID 27618677 DOI: 10.1016/J.Neuron.2016.08.017 |
0.527 |
|
| 2016 |
Wess J. Use of Designer G Protein-Coupled Receptors to Dissect Metabolic Pathways. Trends in Endocrinology and Metabolism: Tem. 27: 600-3. PMID 27381463 DOI: 10.1016/J.Tem.2016.04.001 |
0.402 |
|
| 2016 |
Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ. M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia. Neuron. 90: 1139. PMID 27253449 DOI: 10.1016/J.Neuron.2016.05.017 |
0.483 |
|
| 2016 |
Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, et al. The Gq signalling pathway inhibits brown and beige adipose tissue. Nature Communications. 7: 10895. PMID 26955961 DOI: 10.1038/Ncomms10895 |
0.332 |
|
| 2016 |
Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J. A G Protein-Biased Designer G Protein-Coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-Dependent Signaling Pathways. The Journal of Biological Chemistry. PMID 26851281 DOI: 10.1074/Jbc.M115.702282 |
0.406 |
|
| 2016 |
Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J. Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nature Communications. 7: 10268. PMID 26743492 DOI: 10.1038/Ncomms10268 |
0.366 |
|
| 2015 |
Rossi M, Ruiz de Azua I, Barella LF, Sakamoto W, Zhu L, Cui Y, Lu H, Rebholz H, Matschinsky FM, Doliba NM, Butcher AJ, Tobin AB, Wess J. CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 26598688 DOI: 10.1073/Pnas.1519430112 |
0.384 |
|
| 2015 |
Shen W, Plotkin JL, Francardo V, Ko WK, Xie Z, Li Q, Fieblinger T, Wess J, Neubig RR, Lindsley CW, Conn PJ, Greengard P, Bezard E, Cenci MA, Surmeier DJ. M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia. Neuron. 88: 762-773. PMID 26590347 DOI: 10.1016/J.Neuron.2015.10.039 |
0.405 |
|
| 2015 |
Rossi M, Cui Z, Nakajima K, Hu J, Zhu L, Wess J. Virus-Mediated Expression of DREADDs for In Vivo Metabolic Studies. Methods in Molecular Biology (Clifton, N.J.). 1335: 205-21. PMID 26260603 DOI: 10.1007/978-1-4939-2914-6_14 |
0.409 |
|
| 2015 |
Gould RW, Dencker D, Grannan M, Bubser M, Zhan X, Wess J, Xiang Z, Locuson C, Lindsley CW, Conn PJ, Jones CK. A role for the M1 muscarinic acetylcholine receptor in top-down cognitive processing using a touchscreen visual discrimination task in mice. Acs Chemical Neuroscience. PMID 26176846 DOI: 10.1021/Acschemneuro.5B00123 |
0.441 |
|
| 2015 |
Darby M, Schnoeller C, Vira A, Culley FJ, Culley F, Bobat S, Logan E, Kirstein F, Wess J, Cunningham AF, Brombacher F, Selkirk ME, Horsnell WG. The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection. Plos Pathogens. 11: e1004636. PMID 25629518 DOI: 10.1371/Journal.Ppat.1004636 |
0.414 |
|
| 2015 |
Kistemaker LE, van Os RP, Dethmers-Ausema A, Bos IS, Hylkema MN, van den Berge M, Hiemstra PS, Wess J, Meurs H, Kerstjens HA, Gosens R. Muscarinic M3 receptors on structural cells regulate cigarette smoke-induced neutrophilic airway inflammation in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 308: L96-103. PMID 25381025 DOI: 10.1152/Ajplung.00259.2014 |
0.492 |
|
| 2015 |
Kaiser E, Schröder L, Wiesen K, Wess J, Tian Q, Kaestner L, Lipp P. Novel Roles of Gq-Dependent Signal Transduction for Cardiac Pacemaking and Cardiac Impulse Propagation Studied by Gq-KO and a DREADD Biophysical Journal. 108: 131a-132a. DOI: 10.1016/J.Bpj.2014.11.732 |
0.344 |
|
| 2014 |
Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, et al. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. Acs Chemical Neuroscience. 5: 920-42. PMID 25137629 DOI: 10.1021/Cn500128B |
0.543 |
|
| 2014 |
Kruse AC, Kobilka BK, Gautam D, Sexton PM, Christopoulos A, Wess J. Muscarinic acetylcholine receptors: novel opportunities for drug development. Nature Reviews. Drug Discovery. 13: 549-60. PMID 24903776 DOI: 10.1038/Nrd4295 |
0.527 |
|
| 2014 |
Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. The Journal of Biological Chemistry. 289: 14321-30. PMID 24695732 DOI: 10.1074/Jbc.M114.550384 |
0.506 |
|
| 2014 |
Kruse AC, Hu J, Kobilka BK, Wess J. Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development. Current Opinion in Pharmacology. 16: 24-30. PMID 24662799 DOI: 10.1016/J.Coph.2014.02.006 |
0.517 |
|
| 2014 |
Procino G, Milano S, Carmosino M, Barbieri C, Nicoletti MC, Li JH, Wess J, Svelto M. Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice. Kidney International. 86: 127-38. PMID 24522493 DOI: 10.1038/Ki.2014.10 |
0.332 |
|
| 2014 |
Byun NE, Grannan M, Bubser M, Barry RL, Thompson A, Rosanelli J, Gowrishankar R, Kelm ND, Damon S, Bridges TM, Melancon BJ, Tarr JC, Brogan JT, Avison MJ, Deutch AY, ... Wess J, et al. Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1578-93. PMID 24442096 DOI: 10.1038/Npp.2014.2 |
0.502 |
|
| 2014 |
Gericke A, Steege A, Manicam C, Böhmer T, Wess J, Pfeiffer N. Role of the M3 muscarinic acetylcholine receptor subtype in murine ophthalmic arteries after endothelial removal Investigative Ophthalmology and Visual Science. 55: 625-631. PMID 24408978 DOI: 10.1167/Iovs.13-13549 |
0.501 |
|
| 2014 |
Kistemaker LEM, Bos ST, Mudde WM, Hylkema MN, Hiemstra PS, Wess J, Meurs H, Kerstjens HAM, Gosens R. Muscarinic M3 receptors contribute to allergen-induced airway remodeling in mice American Journal of Respiratory Cell and Molecular Biology. 50: 690-698. PMID 24156289 DOI: 10.1165/rcmb.2013-0220OC |
0.421 |
|
| 2014 |
Kruse AC, Li J, Hu J, Kobilka BK, Wess J. Novel insights into M3 muscarinic acetylcholine receptor physiology and structure. Journal of Molecular Neuroscience : Mn. 53: 316-23. PMID 24068573 DOI: 10.1007/S12031-013-0127-0 |
0.542 |
|
| 2013 |
Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, ... ... Wess J, et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 504: 101-6. PMID 24256733 DOI: 10.1038/Nature12735 |
0.501 |
|
| 2013 |
Hu J, Hu K, Liu T, Stern MK, Mistry R, Challiss RA, Costanzi S, Wess J. Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation. The Journal of Biological Chemistry. 288: 34777-90. PMID 24133207 DOI: 10.1074/Jbc.M113.503714 |
0.433 |
|
| 2013 |
Kruse AC, Weiss DR, Rossi M, Hu J, Hu K, Eitel K, Gmeiner P, Wess J, Kobilka BK, Shoichet BK. Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. Molecular Pharmacology. 84: 528-40. PMID 23887926 DOI: 10.1124/Mol.113.087551 |
0.575 |
|
| 2013 |
Li JH, Jain S, McMillin SM, Cui Y, Gautam D, Sakamoto W, Lu H, Jou W, McGuinness OP, Gavrilova O, Wess J. A novel experimental strategy to assess the metabolic effects of selective activation of a Gq- coupled receptor in hepatocytes in vivo Endocrinology. 154: 3539-3551. PMID 23861369 DOI: 10.1210/En.2012-2127 |
0.474 |
|
| 2013 |
Ferguson SM, Phillips PE, Roth BL, Wess J, Neumaier JF. Direct-pathway striatal neurons regulate the retention of decision-making strategies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11668-76. PMID 23843534 DOI: 10.1523/Jneurosci.4783-12.2013 |
0.304 |
|
| 2013 |
Nakajima K, Jain S, de Azua IR, McMillin SM, Rossi M, Wess J. Minireview: Novel aspects of M3 muscarinic receptor signaling in pancreatic β-cells Molecular Endocrinology. 27: 1208-1216. PMID 23820900 DOI: 10.1210/Me.2013-1084 |
0.472 |
|
| 2013 |
Wess J, Nakajima K, Jain S. Novel designer receptors to probe GPCR signaling and physiology Trends in Pharmacological Sciences. 34: 385-392. PMID 23769625 DOI: 10.1016/J.Tips.2013.04.006 |
0.478 |
|
| 2013 |
Jain S, De Azua IR, Lu H, White MF, Guettier JM, Wess J. Chronic activation of a designer Gq-coupled receptor improves β cell function Journal of Clinical Investigation. 123: 1750-1762. PMID 23478411 DOI: 10.1172/Jci66432 |
0.397 |
|
| 2013 |
Kistemaker LEM, Bos IST, Hylkema MN, Nawijn MC, Hiemstra PS, Wess J, Meurs H, Kerstjens HAM, Gosens R. Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice European Respiratory Journal. 42: 1677-1688. PMID 23397297 DOI: 10.1183/09031936.00112412 |
0.415 |
|
| 2013 |
Arteaga-Solis E, Zee T, Emala CW, Vinson C, Wess J, Karsenty G. Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metabolism. 17: 35-48. PMID 23312282 DOI: 10.1016/J.Cmet.2012.12.004 |
0.323 |
|
| 2013 |
Farrell MS, Pei Y, Wan Y, Yadav PN, Daigle TL, Urban DJ, Lee HM, Sciaky N, Simmons A, Nonneman RJ, Huang XP, Hufeisen SJ, Guettier JM, Moy SS, Wess J, et al. A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 854-62. PMID 23303063 DOI: 10.1038/Npp.2012.251 |
0.38 |
|
| 2013 |
Forrest D, Wess J. A heartfelt response: new thyroid hormone-sensitive neurons in the hypothalamus. The Journal of Clinical Investigation. 123: 117-20. PMID 23257363 DOI: 10.1172/Jci67448 |
0.343 |
|
| 2012 |
Kohlmeier KA, Ishibashi M, Wess J, Bickford ME, Leonard CS. Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus. Journal of Neurophysiology. 108: 2751-66. PMID 22956788 DOI: 10.1152/Jn.01120.2011 |
0.538 |
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| 2012 |
Nakajima KI, Wess J. Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor Molecular Pharmacology. 82: 575-582. PMID 22821234 DOI: 10.1124/Mol.112.080358 |
0.462 |
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| 2012 |
De Azua IR, Nakajima KI, Rossi M, Cui Y, Jou W, Gavrilova O, Wess J. Spinophilin as a novel regulator of M3 muscarinic receptor-mediated insulin release in vitro and in vivo Faseb Journal. 26: 4275-4286. PMID 22730439 DOI: 10.1096/Fj.12-204644 |
0.486 |
|
| 2012 |
Dencker D, Weikop P, Sørensen G, Woldbye DPD, Wörtwein G, Wess J, Fink-Jensen A. An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine Psychopharmacology. 224: 277-287. PMID 22648127 DOI: 10.1007/S00213-012-2751-8 |
0.456 |
|
| 2012 |
Ruiz De Azua I, Gautam D, Jain S, Guettier JM, Wess J. Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors Life Sciences. 91: 986-991. PMID 22525375 DOI: 10.1016/J.Lfs.2012.04.010 |
0.55 |
|
| 2012 |
Zheng F, Wess J, Alzheimer C. M 2 muscarinic acetylcholine receptors regulate long-term potentiation at hippocampal CA3 pyramidal cell synapses in an input-specific fashion Journal of Neurophysiology. 108: 91-100. PMID 22490561 DOI: 10.1152/Jn.00740.2011 |
0.475 |
|
| 2012 |
Dencker D, Thomsen M, Wörtwein G, Weikop P, Cui Y, Jeon J, Wess J, Fink-Jensen A. Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease. Acs Chemical Neuroscience. 3: 80-89. PMID 22389751 DOI: 10.1021/Cn200110Q |
0.777 |
|
| 2012 |
Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature. 482: 552-6. PMID 22358844 DOI: 10.1038/Nature10867 |
0.539 |
|
| 2012 |
Hollenhorst MI, Lips KS, Wolff M, Wess J, Gerbig S, Takats Z, Kummer W, Fronius M. Luminal cholinergic signalling in airway lining fluid: A novel mechanism for activating chloride secretion via Ca 2+-dependent Cl - and K + channels British Journal of Pharmacology. 166: 1388-1402. PMID 22300281 DOI: 10.1111/J.1476-5381.2012.01883.X |
0.367 |
|
| 2012 |
Wess J. Novel muscarinic receptor mutant mouse models Handbook of Experimental Pharmacology. 208: 95-117. PMID 22222697 DOI: 10.1007/978-3-642-23274-9_6 |
0.518 |
|
| 2012 |
Guo JD, Hazra R, Dabrowska J, Muly EC, Wess J, Rainnie DG. Presynaptic muscarinic M(2) receptors modulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuropharmacology. 62: 1671-83. PMID 22166222 DOI: 10.1016/J.Neuropharm.2011.11.013 |
0.562 |
|
| 2012 |
Veeraragavan S, Graham D, Bui N, Yuva-Paylor LA, Wess J, Paylor R. Genetic reduction of muscarinic M 4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS) Behavioural Brain Research. 228: 1-8. PMID 22123412 DOI: 10.1016/J.Bbr.2011.11.018 |
0.534 |
|
| 2012 |
Hu J, Thor D, Zhou Y, Liu T, Wang Y, McMillin SM, Mistry R, Challiss RAJ, Costanzi S, Wess J. Structural aspects of M3 muscarinic acetylcholine receptor dimer formation and activation Faseb Journal. 26: 604-616. PMID 22031716 DOI: 10.1096/fj.11-191510 |
0.323 |
|
| 2012 |
Thomsen M, Lindsley CW, Conn PJ, Wessell JE, Fulton BS, Wess J, Caine SB. Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice Psychopharmacology. 220: 673-685. PMID 21964721 DOI: 10.1007/S00213-011-2516-9 |
0.769 |
|
| 2012 |
Dencker D, Thomsen M, Wörtwein G, Weikop P, Cui Y, Jeon J, Wess J, Fink-Jensen A. Muscarinic acetylcholine receptor subtypes as potential drug targets for the treatment of schizophrenia, drug abuse, and Parkinson's disease Acs Chemical Neuroscience. 3: 80-89. DOI: 10.1021/cn200110q |
0.65 |
|
| 2011 |
Challiss RAJ, Wess J. Receptors: GPCR-G protein preassembly? Nature Chemical Biology. 7: 657-658. PMID 21931312 DOI: 10.1038/Nchembio.665 |
0.367 |
|
| 2011 |
Bartko SJ, Romberg C, White B, Wess J, Bussey TJ, Saksida LM. Intact attentional processing but abnormal responding in M1 muscarinic receptor-deficient mice using an automated touchscreen method. Neuropharmacology. 61: 1366-78. PMID 21903112 DOI: 10.1016/J.Neuropharm.2011.08.023 |
0.482 |
|
| 2011 |
Gericke A, Sniatecki JJ, Goloborodko E, Steege A, Zavaritskaya O, Vetter JM, Grus FH, Patzak A, Wess J, Pfeiffer N. Identification of the muscarinic acetylcholine receptor subtype mediating cholinergic vasodilation in murine retinal arterioles Investigative Ophthalmology and Visual Science. 52: 7479-7484. PMID 21873683 DOI: 10.1167/Iovs.11-7370 |
0.572 |
|
| 2011 |
Raufman JP, Shant J, Xie G, Cheng K, Gao XM, Shiu B, Shah N, Drachenberg CB, Heath J, Wess J, Khurana S. Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice. Carcinogenesis. 32: 1396-402. PMID 21705482 DOI: 10.1093/Carcin/Bgr118 |
0.468 |
|
| 2011 |
McMillin SM, Heusel M, Liu T, Costanzi S, Wess J. Structural basis of M 3 muscarinic receptor dimer/oligomer formation Journal of Biological Chemistry. 286: 28584-28598. PMID 21685385 DOI: 10.1074/Jbc.M111.259788 |
0.483 |
|
| 2011 |
Creson TK, Austin DR, Shaltiel G, Mccammon J, Wess J, Manji HK, Chen G. Lithium treatment attenuates muscarinic M1 receptor dysfunction Bipolar Disorders. 13: 238-249. PMID 21676127 DOI: 10.1111/J.1399-5618.2011.00915.X |
0.488 |
|
| 2011 |
Dencker D, Wörtwein G, Weikop P, Jeon J, Thomsen M, Sager TN, Mørk A, Woldbye DPD, Wess J, Fink-Jensen A. Involvement of a subpopulation of neuronal M 4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M 1/M 4 preferring muscarinic receptor agonist xanomeline Journal of Neuroscience. 31: 5905-5908. PMID 21508215 DOI: 10.1523/Jneurosci.0370-11.2011 |
0.774 |
|
| 2011 |
Schmidt LS, Thomsen M, Weikop P, Dencker D, Wess J, Woldbye DPD, Wortwein G, Fink-Jensen A. Increased cocaine self-administration in M 4 muscarinic acetylcholine receptor knockout mice Psychopharmacology. 216: 367-378. PMID 21373792 DOI: 10.1007/S00213-011-2225-4 |
0.75 |
|
| 2011 |
Gericke A, Sniatecki JJ, Mayer VGA, Goloborodko E, Patzak A, Wess J, Pfeiffer N. Role of m1, m3, and m5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice American Journal of Physiology - Heart and Circulatory Physiology. 300: H1602-H1608. PMID 21335473 DOI: 10.1152/ajpheart.00982.2010 |
0.425 |
|
| 2011 |
Fink-Jensen A, Schmidt LS, Dencker D, Schülein C, Wess J, Wörtwein G, Woldbye DPD. Antipsychotic-induced catalepsy is attenuated in mice lacking the M 4 muscarinic acetylcholine receptor European Journal of Pharmacology. 656: 39-44. PMID 21269601 DOI: 10.1016/J.Ejphar.2011.01.018 |
0.577 |
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| 2011 |
Kupchik YM, Barchad-Avitzur O, Wess J, Ben-Chaim Y, Parnas I, Parnas H. A novel fast mechanism for GPCR-mediated signal transduction--control of neurotransmitter release. The Journal of Cell Biology. 192: 137-51. PMID 21200029 DOI: 10.1085/Jgp1372Oia2 |
0.411 |
|
| 2011 |
Azua IRd, Gautam D, Guettier JM, Wess J. Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: Therapeutic implications Trends in Endocrinology and Metabolism. 22: 74-80. PMID 21106385 DOI: 10.1016/J.Tem.2010.10.004 |
0.483 |
|
| 2011 |
Rosemond E, Rossi M, McMillin SM, Scarselli M, Donaldson JG, Wess J. Regulation of M3 muscarinic receptor expression and function by transmembrane protein 147 Molecular Pharmacology. 79: 251-261. PMID 21056967 DOI: 10.1124/Mol.110.067363 |
0.365 |
|
| 2010 |
Kong KC, Butcher AJ, McWilliams P, Jones D, Wess J, Hamdan FF, Werry T, Rosethorne EM, Charlton SJ, Munson SE, Cragg HA, Smart AD, Tobin AB. M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1 Proceedings of the National Academy of Sciences of the United States of America. 107: 21181-21186. PMID 21078968 DOI: 10.1073/Pnas.1011651107 |
0.537 |
|
| 2010 |
Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. The Journal of Biological Chemistry. 285: 40427-37. PMID 20940295 DOI: 10.1074/Jbc.M110.176966 |
0.505 |
|
| 2010 |
Gautam D, De Azua IR, Li JH, Guettier JM, Heard T, Cui Y, Lu H, Jou W, Gavrilova O, Zawalich WS, Wess J. Beneficial metabolic effects caused by persistent activation of β-cell M3 muscarinic acetylcholine receptors in transgenic mice Endocrinology. 151: 5185-5194. PMID 20843999 DOI: 10.1210/En.2010-0519 |
0.412 |
|
| 2010 |
Hu J, Wang Y, Zhang X, Lloyd JR, Li JH, Karpiak J, Costanzi S, Wess J. Structural basis of G protein-coupled receptor-G protein interactions. Nature Chemical Biology. 6: 541-8. PMID 20512139 DOI: 10.1038/Nchembio.385 |
0.455 |
|
| 2010 |
Maison SF, Liu XP, Vetter DE, Eatock RA, Nathanson NM, Wess J, Liberman MC. Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 6751-62. PMID 20463237 DOI: 10.1523/Jneurosci.5080-09.2010 |
0.523 |
|
| 2010 |
Poulin B, Butcher A, McWilliams P, Bourgognon JM, Pawlak R, Kong KC, Bottrill A, Mistry S, Wess J, Rosethorne EM, Charlton SJ, Tobin AB. The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 107: 9440-5. PMID 20439723 DOI: 10.1073/Pnas.0914801107 |
0.569 |
|
| 2010 |
De Azua IR, Scarselli M, Rosemond E, Gautam D, Jou W, Gavrilova O, Ebert PJ, Levitt P, Wess J. RGS4 is a negative regulator of insulin release from pancreatic β-cells in vitro and in vivo Proceedings of the National Academy of Sciences of the United States of America. 107: 7999-8004. PMID 20385802 DOI: 10.1073/Pnas.1003655107 |
0.354 |
|
| 2010 |
Davis AA, Fritz JJ, Wess J, Lah JJ, Levey AI. Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4190-6. PMID 20335454 DOI: 10.1523/Jneurosci.6393-09.2010 |
0.447 |
|
| 2010 |
Threlfell S, Clements MA, Khodai T, Pienaar IS, Exley R, Wess J, Cragg SJ. Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3398-408. PMID 20203199 DOI: 10.1523/Jneurosci.5620-09.2010 |
0.46 |
|
| 2010 |
Khurana S, Shah N, Cheng K, Shiu B, Samimi R, Belo A, Shant J, Drachenberg C, Wess J, Raufman JP. Scopolamine treatment and muscarinic receptor subtype-3 gene ablation augment azoxymethane-induced murine liver injury. The Journal of Pharmacology and Experimental Therapeutics. 333: 639-49. PMID 20197374 DOI: 10.1124/Jpet.109.165118 |
0.354 |
|
| 2010 |
Shi Y, Oury F, Yadav VK, Wess J, Liu XS, Guo XE, Murshed M, Karsenty G. Signaling through the M(3) muscarinic receptor favors bone mass accrual by decreasing sympathetic activity. Cell Metabolism. 11: 231-8. PMID 20197056 DOI: 10.1016/J.Cmet.2010.01.005 |
0.33 |
|
| 2010 |
Jeon J, Dencker D, Wörtwein G, Woldbye DP, Cui Y, Davis AA, Levey AI, Schütz G, Sager TN, Mørk A, Li C, Deng CX, Fink-Jensen A, Wess J. A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2396-405. PMID 20147565 DOI: 10.1523/Jneurosci.3843-09.2010 |
0.534 |
|
| 2010 |
Wess J. More Is Not Always Better: α2A-Adrenoceptor Expression in Type 2 Diabetes Cell Metabolism. 11: 3-5. PMID 20085729 DOI: 10.1016/J.Cmet.2009.12.002 |
0.338 |
|
| 2010 |
Balasubramanian R, Ruiz de Azua I, Wess J, Jacobson KA. Activation of distinct P2Y receptor subtypes stimulates insulin secretion in MIN6 mouse pancreatic beta cells. Biochemical Pharmacology. 79: 1317-26. PMID 20067775 DOI: 10.1016/J.Bcp.2009.12.026 |
0.428 |
|
| 2010 |
Schlenz H, Kummer W, Jositsch G, Wess J, Krasteva G. Muscarinic receptor-mediated bronchoconstriction is coupled to caveolae in murine airways American Journal of Physiology - Lung Cellular and Molecular Physiology. 298: L626-L636. PMID 20023174 DOI: 10.1152/Ajplung.00261.2009 |
0.416 |
|
| 2010 |
Thomsen M, Wess J, Fulton BS, Fink-Jensen A, Caine SB. Modulation of prepulse inhibition through both M1 and M 4 muscarinic receptors in mice Psychopharmacology. 208: 401-416. PMID 20013114 DOI: 10.1007/S00213-009-1740-Z |
0.768 |
|
| 2010 |
Thomsen M, Conn PJ, Lindsley C, Wess J, Boon JY, Fulton BS, Fink-Jensen A, Caine SB. Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation Journal of Pharmacology and Experimental Therapeutics. 332: 959-969. PMID 19996296 DOI: 10.1124/Jpet.109.162057 |
0.746 |
|
| 2010 |
Schmidt LS, Miller AD, Lester DB, Bay-Richter C, Schülein C, Frikke-Schmidt H, Wess J, Blaha CD, Woldbye DP, Fink-Jensen A, Wortwein G. Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice. Psychopharmacology. 207: 547-58. PMID 19820917 DOI: 10.1007/S00213-009-1685-2 |
0.453 |
|
| 2009 |
Tanahashi Y, Unno T, Matsuyama H, Ishii T, Yamada M, Wess J, Komori S. Multiple muscarinic pathways mediate the suppression of voltage-gated Ca2+ channels in mouse intestinal smooth muscle cells. British Journal of Pharmacology. 158: 1874-83. PMID 20050185 DOI: 10.1111/J.1476-5381.2009.00475.X |
0.331 |
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| 2009 |
Wright MC, Potluri S, Wang X, Dentcheva E, Gautam D, Tessler A, Wess J, Rich MM, Son YJ. Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14942-55. PMID 19940190 DOI: 10.1523/Jneurosci.2276-09.2009 |
0.342 |
|
| 2009 |
Guettier JM, Gautam D, Scarselli M, Ruiz de Azua I, Li JH, Rosemond E, Ma X, Gonzalez FJ, Armbruster BN, Lu H, Roth BL, Wess J. A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proceedings of the National Academy of Sciences of the United States of America. 106: 19197-202. PMID 19858481 DOI: 10.1073/Pnas.0906593106 |
0.336 |
|
| 2009 |
Pooput C, Rosemond E, Karpiak J, Deflorian F, Vilar S, Costanzi S, Wess J, Kirk KL. Structural basis of the selectivity of the β2-adrenergic receptor for fluorinated catecholamines Bioorganic and Medicinal Chemistry. 17: 7987-7992. PMID 19857969 DOI: 10.1016/J.Bmc.2009.10.015 |
0.478 |
|
| 2009 |
Li JH, Gautam D, Han SJ, Guettier JM, Cui Y, Lu H, Deng C, O'Hare J, Jou W, Gavrilova O, Buettner C, Wess J. Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice Diabetes. 58: 2776-2787. PMID 19752163 DOI: 10.2337/Db09-0522 |
0.342 |
|
| 2009 |
Li JH, Chou CL, Li B, Gavrilova O, Eisner C, Schnermann J, Anderson SA, Deng CX, Knepper MA, Wess J. A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus. The Journal of Clinical Investigation. 119: 3115-26. PMID 19729836 DOI: 10.1172/Jci39680 |
0.433 |
|
| 2009 |
Liu QH, Zheng YM, Korde AS, Yadav VR, Rathore R, Wess J, Wang YX. Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle. Proceedings of the National Academy of Sciences of the United States of America. 106: 11418-23. PMID 19549818 DOI: 10.1073/Pnas.0813307106 |
0.303 |
|
| 2009 |
Kitazawa T, Asakawa K, Nakamura T, Teraoka H, Unno T, Komori S, Yamada M, Wess J. M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 330: 487-93. PMID 19429792 DOI: 10.1124/Jpet.109.153304 |
0.583 |
|
| 2009 |
Gericke A, Mayer VGA, Steege A, Patzak A, Neumann U, Grus FH, Joachim SC, Choritz L, Wess J, Pfeiffer N. Cholinergic responses of ophthalmic arteries in M3 and M5 muscarinic acetylcholine receptor knockout mice Investigative Ophthalmology and Visual Science. 50: 4822-4827. PMID 19407017 DOI: 10.1167/iovs.09-3600 |
0.454 |
|
| 2009 |
Kitamura N, Araya R, Kudoh M, Kishida H, Kimura T, Murayama M, Takashima A, Sakamaki Y, Hashikawa T, Ito S, Ohtsuki S, Terasaki T, Wess J, Yamada M. Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency. Plos One. 4: e5159. PMID 19357782 DOI: 10.1371/Journal.Pone.0005159 |
0.432 |
|
| 2009 |
Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y, Parlow AF, Gavrilova O, Szalayova I, Mezey E, Wess J. Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proceedings of the National Academy of Sciences of the United States of America. 106: 6398-403. PMID 19332789 DOI: 10.1073/Pnas.0900977106 |
0.541 |
|
| 2009 |
Klein MK, Haberberger RV, Hartmann P, Faulhammer P, Lips KS, Krain B, Wess J, Kummer W, König P. Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development. The European Respiratory Journal. 33: 1113-21. PMID 19213795 DOI: 10.1183/09031936.00015108 |
0.567 |
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| 2009 |
Jositsch G, Papadakis T, Haberberger RV, Wolff M, Wess J, Kummer W. Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 379: 389-95. PMID 18974978 DOI: 10.1007/S00210-008-0365-9 |
0.369 |
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| 2008 |
Wess J, Han SJ, Kim SK, Jacobson KA, Li JH. Conformational changes involved in G-protein-coupled-receptor activation. Trends in Pharmacological Sciences. 29: 616-25. PMID 18838178 DOI: 10.1016/J.Tips.2008.08.006 |
0.468 |
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| 2008 |
Schliebe N, Strotmann R, Busse K, Mitschke D, Biebermann H, Schomburg L, Köhrle J, Bär J, Römpler H, Wess J, Schöneberg T, Sangkuhl K. V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis. American Journal of Physiology. Renal Physiology. 295: F1177-90. PMID 18715941 DOI: 10.1152/Ajprenal.00465.2007 |
0.322 |
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| 2008 |
Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nature Methods. 5: 673-8. PMID 18668035 DOI: 10.1038/Nmeth.1232 |
0.396 |
|
| 2008 |
Bonsi P, Martella G, Cuomo D, Platania P, Sciamanna G, Bernardi G, Wess J, Pisani A. Loss of muscarinic autoreceptor function impairs long-term depression but not long-term potentiation in the striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6258-63. PMID 18550768 DOI: 10.1523/Jneurosci.1678-08.2008 |
0.524 |
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| 2008 |
Raufman JP, Samimi R, Shah N, Khurana S, Shant J, Drachenberg C, Xie G, Wess J, Cheng K. Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Research. 68: 3573-8. PMID 18483237 DOI: 10.1158/0008-5472.Can-07-6810 |
0.417 |
|
| 2008 |
Gautam D, Jeon J, Li JH, Han SJ, Hamdan FF, Cui Y, Lu H, Deng C, Gavrilova O, Wess J. Metabolic roles of the M3 muscarinic acetylcholine receptor studied with M3 receptor mutant mice: a review. Journal of Receptor and Signal Transduction Research. 28: 93-108. PMID 18437633 DOI: 10.1080/10799890801942002 |
0.579 |
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| 2008 |
Wang H, Liang S, Burgdorf J, Wess J, Yeomans J. Ultrasonic vocalizations induced by sex and amphetamine in M2, M4, M5 muscarinic and D2 dopamine receptor knockout mice. Plos One. 3: e1893. PMID 18382674 DOI: 10.1371/Journal.Pone.0001893 |
0.417 |
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| 2008 |
Bainbridge NK, Koselke LR, Jeon J, Bailey KR, Wess J, Crawley JN, Wrenn CC. Learning and memory impairments in a congenic C57BL/6 strain of mice that lacks the M2 muscarinic acetylcholine receptor subtype. Behavioural Brain Research. 190: 50-8. PMID 18346798 DOI: 10.1016/j.bbr.2008.02.001 |
0.429 |
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| 2008 |
Li JH, Hamdan FF, Kim SK, Jacobson KA, Zhang X, Han SJ, Wess J. Ligand-specific changes in M3 muscarinic acetylcholine receptor structure detected by a disulfide scanning strategy. Biochemistry. 47: 2776-88. PMID 18247581 DOI: 10.1021/Bi7019113 |
0.564 |
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| 2008 |
Kitazawa T, Hirama R, Masunaga K, Nakamura T, Asakawa K, Cao J, Teraoka H, Unno T, Komori S, Yamada M, Wess J, Taneike T. Muscarinic receptor subtypes involved in carbachol-induced contraction of mouse uterine smooth muscle. Naunyn-Schmiedeberg's Archives of Pharmacology. 377: 503-13. PMID 18071676 DOI: 10.1007/S00210-007-0223-1 |
0.585 |
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| 2008 |
Shirey JK, Xiang Z, Orton D, Brady AE, Johnson KA, Williams R, Ayala JE, Rodriguez AL, Wess J, Weaver D, Niswender CM, Conn PJ. An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nature Chemical Biology. 4: 42-50. PMID 18059262 DOI: 10.1038/Nchembio.2007.55 |
0.526 |
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| 2008 |
Hu J, Li J, Costanzi S, Zhang X, Wess J. Mapping of Contact Sites Between the M3 Muscarinic Acetylcholine Receptor and Gq by Cross‐linking Approaches The Faseb Journal. 22: 293-293. DOI: 10.1096/Fasebj.22.2_Supplement.293 |
0.471 |
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| 2008 |
Rosemond E, Scarselli M, De Azua IR, Wess J. Identification of a novel protein partner of the M3 muscarinic acetylcholine receptor The Faseb Journal. 22: 250-250. DOI: 10.1096/Fasebj.22.2_Supplement.250 |
0.562 |
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| 2007 |
LaCroix C, Freeling J, Giles A, Wess J, Li YF. Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress. American Journal of Physiology. Heart and Circulatory Physiology. 294: H810-20. PMID 18055517 DOI: 10.1152/AJPHEART.00724.2007 |
0.348 |
|
| 2007 |
Gautam D, Han SJ, Duttaroy A, Mears D, Hamdan FF, Li JH, Cui Y, Jeon J, Wess J. Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis. Diabetes, Obesity & Metabolism. 9: 158-69. PMID 17919190 DOI: 10.1111/J.1463-1326.2007.00781.X |
0.456 |
|
| 2007 |
Zhang HM, Zhou HY, Chen SR, Gautam D, Wess J, Pan HL. Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 323: 963-71. PMID 17878406 DOI: 10.1124/Jpet.107.127795 |
0.494 |
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| 2007 |
Wess J, Eglen RM, Gautam D. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nature Reviews. Drug Discovery. 6: 721-33. PMID 17762886 DOI: 10.1038/Nrd2379 |
0.546 |
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| 2007 |
Li JH, Han SJ, Hamdan FF, Kim SK, Jacobson KA, Bloodworth LM, Zhang X, Wess J. Distinct structural changes in a G protein-coupled receptor caused by different classes of agonist ligands. The Journal of Biological Chemistry. 282: 26284-93. PMID 17623649 DOI: 10.1074/Jbc.M704875200 |
0.506 |
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| 2007 |
Sakamoto T, Unno T, Kitazawa T, Taneike T, Yamada M, Wess J, Nishimura M, Komori S. Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells. The Journal of Physiology. 582: 41-61. PMID 17463038 DOI: 10.1113/Jphysiol.2007.133165 |
0.413 |
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| 2007 |
Zarghooni S, Wunsch J, Bodenbenner M, Brüggmann D, Grando SA, Schwantes U, Wess J, Kummer W, Lips KS. Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium. Life Sciences. 80: 2308-13. PMID 17337281 DOI: 10.1016/J.Lfs.2007.01.046 |
0.344 |
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| 2007 |
Thomsen M, Wörtwein G, Fink-Jensen A, Woldbye DP, Wess J, Caine SB. Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice. Psychopharmacology. 192: 97-110. PMID 17310388 DOI: 10.1007/S00213-006-0682-Y |
0.791 |
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| 2007 |
Vezys V, Masopust D, Desmarets M, Wess J, Zimring JC. Analysis of CD8+ T cell-mediated anti-viral responses in mice with targeted deletions of the M1 or M5 muscarinic cholinergic receptors. Life Sciences. 80: 2330-3. PMID 17286988 DOI: 10.1016/J.Lfs.2007.01.001 |
0.463 |
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| 2007 |
Scarselli M, Li B, Kim SK, Wess J. Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation. The Journal of Biological Chemistry. 282: 7385-96. PMID 17213190 DOI: 10.1074/Jbc.M610394200 |
0.42 |
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| 2007 |
Li B, Scarselli M, Knudsen CD, Kim SK, Jacobson KA, McMillin SM, Wess J. Rapid identification of functionally critical amino acids in a G protein-coupled receptor. Nature Methods. 4: 169-74. PMID 17206152 DOI: 10.1038/Nmeth990 |
0.45 |
|
| 2007 |
Kitazawa T, Hashiba K, Cao J, Unno T, Komori S, Yamada M, Wess J, Taneike T. Functional roles of muscarinic M2 and M3 receptors in mouse stomach motility: studies with muscarinic receptor knockout mice. European Journal of Pharmacology. 554: 212-22. PMID 17113073 DOI: 10.1016/J.Ejphar.2006.10.013 |
0.533 |
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| 2007 |
Li JH, Han S, Hamdan FF, Kim S, Jacobson KA, Bloodworth LM, Zhang X, Wess J. Identification of distinct, ligand‐specific structural changes in a G protein‐coupled receptor The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A425-C |
0.409 |
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| 2007 |
Rosemond E, Li B, McMillin S, Wess J. A novel strategy to identify proteins that interact with the M3 muscarinic receptor in vivo using the split-ubiquitin system in yeast The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A424-A |
0.519 |
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| 2007 |
Araya R, Kitamura N, Kimura T, Wess J, Yamada M. Estrogen prevents cerebrovascular deficits by the lack of M5 muscarinic acetylcholine receptor through MAPK activation Neuroscience Research. 58. DOI: 10.1016/J.Neures.2007.06.361 |
0.56 |
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| 2006 |
Gautam D, Duttaroy A, Cui Y, Han SJ, Deng C, Seeger T, Alzheimer C, Wess J. M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes. Journal of Molecular Neuroscience : Mn. 30: 157-60. PMID 17192665 DOI: 10.1385/Jmn:30:1:157 |
0.572 |
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| 2006 |
Kummer W, Wiegand S, Akinci S, Schinkel AH, Wess J, Koepsell H, Haberberger RV, Lips KS. Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse. Journal of Molecular Neuroscience : Mn. 30: 67-8. PMID 17192631 DOI: 10.1385/Jmn:30:1:67 |
0.331 |
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| 2006 |
Unno T, Matsuyama H, Izumi Y, Yamada M, Wess J, Komori S. Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice. British Journal of Pharmacology. 149: 1022-30. PMID 17099717 DOI: 10.1038/Sj.Bjp.0706955 |
0.554 |
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| 2006 |
Gautam D, Gavrilova O, Jeon J, Pack S, Jou W, Cui Y, Li JH, Wess J. Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency. Cell Metabolism. 4: 363-75. PMID 17084710 DOI: 10.1016/J.Cmet.2006.09.008 |
0.536 |
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| 2006 |
Origlia N, Kuczewski N, Aztiria E, Gautam D, Wess J, Domenici L. Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex. The Journal of Physiology. 577: 829-40. PMID 17023506 DOI: 10.1113/Jphysiol.2006.117119 |
0.496 |
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| 2006 |
Araya R, Noguchi T, Yuhki M, Kitamura N, Higuchi M, Saido TC, Seki K, Itohara S, Kawano M, Tanemura K, Takashima A, Yamada K, Kondoh Y, Kanno I, Wess J, et al. Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiology of Disease. 24: 334-44. PMID 16956767 DOI: 10.1016/J.Nbd.2006.07.010 |
0.44 |
|
| 2006 |
Gautam D, Han SJ, Hamdan FF, Jeon J, Li B, Li JH, Cui Y, Mears D, Lu H, Deng C, Heard T, Wess J. A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metabolism. 3: 449-61. PMID 16753580 DOI: 10.1016/J.Cmet.2006.04.009 |
0.421 |
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| 2006 |
Ward SD, Hamdan FF, Bloodworth LM, Siddiqui NA, Li JH, Wess J. Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor. Biochemistry. 45: 676-85. PMID 16411743 DOI: 10.1021/Bi051503Q |
0.492 |
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| 2006 |
Zhang HM, Chen SR, Matsui M, Gautam D, Wess J, Pan HL. Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice. Molecular Pharmacology. 69: 1048-55. PMID 16365281 DOI: 10.1124/Mol.105.018069 |
0.508 |
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| 2006 |
Allen IC, Hartney JM, Coffman TM, Penn RB, Wess J, Koller BH. Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L526-33. PMID 16243899 DOI: 10.1152/Ajplung.00340.2005 |
0.421 |
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| 2005 |
Niebauer RT, Gao ZG, Li B, Wess J, Jacobson KA. Signaling of the Human P2Y(1) Receptor Measured by a Yeast Growth Assay with Comparisons to Assays of Phospholipase C and Calcium Mobilization in 1321N1 Human Astrocytoma Cells. Purinergic Signalling. 1: 241-7. PMID 16467903 DOI: 10.1007/S11302-005-6310-1 |
0.42 |
|
| 2005 |
Wess J. Allosteric binding sites on muscarinic acetylcholine receptors. Molecular Pharmacology. 68: 1506-9. PMID 16183853 DOI: 10.1124/Mol.105.019141 |
0.447 |
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| 2005 |
Thomsen M, Woldbye DP, Wörtwein G, Fink-Jensen A, Wess J, Caine SB. Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8141-9. PMID 16148222 DOI: 10.1523/Jneurosci.2077-05.2005 |
0.706 |
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| 2005 |
Goutagny R, Comte JC, Salvert D, Gomeza J, Yamada M, Wess J, Luppi PH, Fort P. Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors. Neuropsychobiology. 52: 140-6. PMID 16110248 DOI: 10.1159/000087560 |
0.534 |
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| 2005 |
Han SJ, Hamdan FF, Kim SK, Jacobson KA, Bloodworth LM, Li B, Wess J. Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor. The Journal of Biological Chemistry. 280: 34849-58. PMID 16093246 DOI: 10.1074/Jbc.M506711200 |
0.534 |
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| 2005 |
Trendelenburg AU, Meyer A, Wess J, Starke K. Distinct mixtures of muscarinic receptor subtypes mediate inhibition of noradrenaline release in different mouse peripheral tissues, as studied with receptor knockout mice. British Journal of Pharmacology. 145: 1153-9. PMID 15965496 DOI: 10.1038/Sj.Bjp.0706297 |
0.512 |
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| 2005 |
Unno T, Matsuyama H, Sakamoto T, Uchiyama M, Izumi Y, Okamoto H, Yamada M, Wess J, Komori S. M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice. British Journal of Pharmacology. 146: 98-108. PMID 15965495 DOI: 10.1038/Sj.Bjp.0706300 |
0.56 |
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| 2005 |
Khurana S, Yamada M, Wess J, Kennedy RH, Raufman JP. Deoxycholyltaurine-induced vasodilation of rodent aorta is nitric oxide- and muscarinic M(3) receptor-dependent. European Journal of Pharmacology. 517: 103-10. PMID 15964566 DOI: 10.1016/J.Ejphar.2005.05.037 |
0.458 |
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| 2005 |
Xie G, Drachenberg C, Yamada M, Wess J, Raufman JP. Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors. American Journal of Physiology. Gastrointestinal and Liver Physiology. 289: G521-9. PMID 15933222 DOI: 10.1152/Ajpgi.00105.2004 |
0.549 |
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| 2005 |
Kuczewski N, Aztiria E, Gautam D, Wess J, Domenici L. Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice. The Journal of Physiology. 566: 907-19. PMID 15919709 DOI: 10.1113/Jphysiol.2005.089987 |
0.454 |
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| 2005 |
Zimring JC, Kapp LM, Yamada M, Wess J, Kapp JA. Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway. Journal of Neuroimmunology. 164: 66-75. PMID 15913791 DOI: 10.1016/J.Jneuroim.2005.03.018 |
0.495 |
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| 2005 |
Han SJ, Hamdan FF, Kim SK, Jacobson KA, Brichta L, Bloodworth LM, Li JH, Wess J. Pronounced conformational changes following agonist activation of the M(3) muscarinic acetylcholine receptor. The Journal of Biological Chemistry. 280: 24870-9. PMID 15870064 DOI: 10.1074/Jbc.M500379200 |
0.568 |
|
| 2005 |
Gautam D, Han SJ, Heard TS, Cui Y, Miller G, Bloodworth L, Wess J. Cholinergic stimulation of amylase secretion from pancreatic acinar cells studied with muscarinic acetylcholine receptor mutant mice. The Journal of Pharmacology and Experimental Therapeutics. 313: 995-1002. PMID 15764735 DOI: 10.1124/Jpet.105.084855 |
0.567 |
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| 2005 |
Parnas H, Slutsky I, Rashkovan G, Silman I, Wess J, Parnas I. Depolarization initiates phasic acetylcholine release by relief of a tonic block imposed by presynaptic M2 muscarinic receptors. Journal of Neurophysiology. 93: 3257-69. PMID 15703226 DOI: 10.1152/Jn.01131.2004 |
0.493 |
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| 2005 |
Chen SR, Wess J, Pan HL. Functional activity of the M2 and M4 receptor subtypes in the spinal cord studied with muscarinic acetylcholine receptor knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 313: 765-70. PMID 15665136 DOI: 10.1124/Jpet.104.082537 |
0.508 |
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| 2005 |
Li B, Nowak NM, Kim SK, Jacobson KA, Bagheri A, Schmidt C, Wess J. Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor. The Journal of Biological Chemistry. 280: 5664-75. PMID 15572356 DOI: 10.1074/Jbc.M411623200 |
0.553 |
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| 2005 |
Alzheimer C, Wess J. Muskarinische Acetylcholinrezeptoren und die neuronalen Mechanismen kognitiver Leistungen E-Neuroforum. 11. DOI: 10.1515/Nf-2005-0204 |
0.437 |
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| 2004 |
Seeger T, Fedorova I, Zheng F, Miyakawa T, Koustova E, Gomeza J, Basile AS, Alzheimer C, Wess J. M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10117-27. PMID 15537882 DOI: 10.1523/Jneurosci.3581-04.2004 |
0.522 |
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| 2004 |
Gautam D, Heard TS, Cui Y, Miller G, Bloodworth L, Wess J. Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and double-knockout mice. Molecular Pharmacology. 66: 260-7. PMID 15266016 DOI: 10.1124/Mol.66.2.260 |
0.589 |
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| 2004 |
Chernyavsky AI, Arredondo J, Wess J, Karlsson E, Grando SA. Novel signaling pathways mediating reciprocal control of keratinocyte migration and wound epithelialization through M3 and M4 muscarinic receptors. The Journal of Cell Biology. 166: 261-72. PMID 15263021 DOI: 10.1083/Jcb.200401034 |
0.512 |
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| 2004 |
Tzavara ET, Bymaster FP, Davis RJ, Wade MR, Perry KW, Wess J, McKinzie DL, Felder C, Nomikos GG. M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1410-2. PMID 15231726 DOI: 10.1096/Fj.04-1575Fje |
0.508 |
|
| 2004 |
Duttaroy A, Zimliki CL, Gautam D, Cui Y, Mears D, Wess J. Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes. 53: 1714-20. PMID 15220195 DOI: 10.2337/Diabetes.53.7.1714 |
0.505 |
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| 2004 |
Khurana S, Chacon I, Xie G, Yamada M, Wess J, Raufman JP, Kennedy RH. Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-/- mice. European Journal of Pharmacology. 493: 127-32. PMID 15189773 DOI: 10.1016/J.Ejphar.2004.04.012 |
0.487 |
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| 2004 |
Lamping KG, Wess J, Cui Y, Nuno DW, Faraci FM. Muscarinic (M) receptors in coronary circulation: gene-targeted mice define the role of M2 and M3 receptors in response to acetylcholine. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1253-8. PMID 15130910 DOI: 10.1161/01.Atv.0000130661.82773.Ca |
0.562 |
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| 2004 |
Boudinot E, Yamada M, Wess J, Champagnat J, Foutz AS. Ventilatory pattern and chemosensitivity in M1 and M3 muscarinic receptor knockout mice. Respiratory Physiology & Neurobiology. 139: 237-45. PMID 15122990 DOI: 10.1016/J.Resp.2003.10.006 |
0.533 |
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| 2004 |
Nguyen VT, Chernyavsky AI, Arredondo J, Bercovich D, Orr-Urtreger A, Vetter DE, Wess J, Beaudet AL, Kitajima Y, Grando SA. Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes. Experimental Cell Research. 294: 534-49. PMID 15023540 DOI: 10.1016/J.Yexcr.2003.12.010 |
0.444 |
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| 2004 |
Sangkuhl K, Schulz A, Römpler H, Yun J, Wess J, Schöneberg T. Aminoglycoside-mediated rescue of a disease-causing nonsense mutation in the V2 vasopressin receptor gene in vitro and in vivo. Human Molecular Genetics. 13: 893-903. PMID 14998935 DOI: 10.1093/Hmg/Ddh105 |
0.438 |
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| 2004 |
Fisher JT, Vincent SG, Gomeza J, Yamada M, Wess J. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 711-3. PMID 14977875 DOI: 10.1096/Fj.03-0648Fje |
0.521 |
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| 2004 |
Wess J. Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications. Annual Review of Pharmacology and Toxicology. 44: 423-50. PMID 14744253 DOI: 10.1146/Annurev.Pharmtox.44.101802.121622 |
0.554 |
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| 2003 |
Struckmann N, Schwering S, Wiegand S, Gschnell A, Yamada M, Kummer W, Wess J, Haberberger RV. Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice. Molecular Pharmacology. 64: 1444-1451. PMID 14645675 DOI: 10.1124/Mol.64.6.1444 |
0.548 |
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| 2003 |
Yamada M, Basile AS, Fedorova I, Zhang W, Duttaroy A, Cui Y, Lamping KG, Faraci FM, Deng CX, Wess J. Novel insights into M5 muscarinic acetylcholine receptor function by the use of gene targeting technology. Life Sciences. 74: 345-53. PMID 14607263 DOI: 10.1016/J.Lfs.2003.09.022 |
0.611 |
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| 2003 |
Fink-Jensen A, Fedorova I, Wörtwein G, Woldbye DP, Rasmussen T, Thomsen M, Bolwig TG, Knitowski KM, McKinzie DL, Yamada M, Wess J, Basile A. Role for M5 muscarinic acetylcholine receptors in cocaine addiction. Journal of Neuroscience Research. 74: 91-6. PMID 13130510 DOI: 10.1002/Jnr.10728 |
0.75 |
|
| 2003 |
Wess J. Novel insights into muscarinic acetylcholine receptor function using gene targeting technology. Trends in Pharmacological Sciences. 24: 414-20. PMID 12915051 DOI: 10.1016/S0165-6147(03)00195-0 |
0.555 |
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| 2003 |
Schmidt C, Li B, Bloodworth L, Erlenbach I, Zeng FY, Wess J. Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast. Identification of point mutations that "silence" a constitutively active mutant M3 receptor and greatly impair receptor/G protein coupling. The Journal of Biological Chemistry. 278: 30248-60. PMID 12750375 DOI: 10.1074/Jbc.M304991200 |
0.56 |
|
| 2003 |
Bymaster FP, Carter PA, Yamada M, Gomeza J, Wess J, Hamilton SE, Nathanson NM, McKinzie DL, Felder CC. Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. The European Journal of Neuroscience. 17: 1403-10. PMID 12713643 DOI: 10.1046/J.1460-9568.2003.02588.X |
0.551 |
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| 2003 |
Slutsky I, Wess J, Gomeza J, Dudel J, Parnas I, Parnas H. Use of knockout mice reveals involvement of M2-muscarinic receptors in control of the kinetics of acetylcholine release. Journal of Neurophysiology. 89: 1954-67. PMID 12686574 DOI: 10.1152/Jn.00668.2002 |
0.477 |
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| 2003 |
Bymaster FP, McKinzie DL, Felder CC, Wess J. Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochemical Research. 28: 437-42. PMID 12675128 DOI: 10.1023/A:1022844517200 |
0.543 |
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| 2003 |
Jagoda EM, Kiesewetter DO, Shimoji K, Ravasi L, Yamada M, Gomeza J, Wess J, Eckelman WC. Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice. Neuropharmacology. 44: 653-61. PMID 12668051 DOI: 10.1016/S0028-3908(03)00050-9 |
0.489 |
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| 2003 |
Chernyavsky AI, Nguyen VT, Arredondo J, Ndoye A, Zia S, Wess J, Grando SA. The M4 muscarinic receptor-selective effects on keratinocyte crawling locomotion. Life Sciences. 72: 2069-73. PMID 12628458 DOI: 10.1016/S0024-3205(03)00085-7 |
0.526 |
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| 2003 |
Wess J, Duttaroy A, Gomeza J, Zhang W, Yamada M, Felder CC, Bernardini N, Reeh PW. Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: A review Life Sciences. 72: 2047-2054. PMID 12628455 DOI: 10.1016/S0024-3205(03)00082-1 |
0.613 |
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| 2003 |
Trendelenburg AU, Gomeza J, Klebroff W, Zhou H, Wess J. Heterogeneity of presynaptic muscarinic receptors mediating inhibition of sympathetic transmitter release: a study with M2- and M4-receptor-deficient mice. British Journal of Pharmacology. 138: 469-80. PMID 12569072 DOI: 10.1038/Sj.Bjp.0705053 |
0.583 |
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| 2003 |
Xie G, Yamada M, Wess J, Raufman J. The M1 muscarinic receptor is required for full expression of cholinergic agonist-induced pepsinogen secretion Gastroenterology. 124: A141. DOI: 10.1016/S0016-5085(03)80699-6 |
0.565 |
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| 2002 |
Duttaroy A, Gomeza J, Gan JW, Siddiqui N, Basile AS, Harman WD, Smith PL, Felder CC, Levey AI, Wess J. Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice. Molecular Pharmacology. 62: 1084-93. PMID 12391271 DOI: 10.1124/Mol.62.5.1084 |
0.606 |
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| 2002 |
Hemrick-Luecke SK, Bymaster FP, Evans DC, Wess J, Felder CC. Muscarinic agonist-mediated increases in serum corticosterone levels are abolished in m(2) muscarinic acetylcholine receptor knockout mice. The Journal of Pharmacology and Experimental Therapeutics. 303: 99-103. PMID 12235238 DOI: 10.1124/Jpet.102.036020 |
0.593 |
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| 2002 |
Basile AS, Fedorova I, Zapata A, Liu X, Shippenberg T, Duttaroy A, Yamada M, Wess J. Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. Proceedings of the National Academy of Sciences of the United States of America. 99: 11452-7. PMID 12154229 DOI: 10.1073/Pnas.162371899 |
0.572 |
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| 2002 |
Zhang W, Yamada M, Gomeza J, Basile AS, Wess J. Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6347-52. PMID 12151512 DOI: 10.1523/Jneurosci.22-15-06347.2002 |
0.564 |
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| 2002 |
Porter AC, Bymaster FP, DeLapp NW, Yamada M, Wess J, Hamilton SE, Nathanson NM, Felder CC. M1 muscarinic receptor signaling in mouse hippocampus and cortex. Brain Research. 944: 82-9. PMID 12106668 DOI: 10.1016/S0006-8993(02)02721-X |
0.576 |
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| 2002 |
Hamdan FF, Ward SD, Siddiqui NA, Bloodworth LM, Wess J. Use of an in situ disulfide cross-linking strategy to map proximities between amino acid residues in transmembrane domains I and VII of the M3 muscarinic acetylcholine receptor. Biochemistry. 41: 7647-58. PMID 12056896 DOI: 10.1021/Bi016029C |
0.507 |
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| 2002 |
Bernardini N, Roza C, Sauer SK, Gomeza J, Wess J, Reeh PW. Muscarinic M2 receptors on peripheral nerve endings: a molecular target of antinociception. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: RC229. PMID 12045234 DOI: 10.1523/Jneurosci.22-12-J0002.2002 |
0.529 |
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| 2002 |
Stengel PW, Yamada M, Wess J, Cohen ML. M(3)-receptor knockout mice: muscarinic receptor function in atria, stomach fundus, urinary bladder, and trachea. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 282: R1443-9. PMID 11959688 DOI: 10.1152/Ajpregu.00486.2001 |
0.575 |
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| 2002 |
Zhang W, Basile AS, Gomeza J, Volpicelli LA, Levey AI, Wess J. Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1709-17. PMID 11880500 DOI: 10.1523/Jneurosci.22-05-01709.2002 |
0.57 |
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| 2002 |
Fisahn A, Yamada M, Duttaroy A, Gan JW, Deng CX, McBain CJ, Wess J. Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron. 33: 615-24. PMID 11856534 DOI: 10.1016/S0896-6273(02)00587-1 |
0.484 |
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| 2002 |
Zhou H, Meyer A, Starke K, Gomeza J, Wess J, Trendelenburg AU. Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M(2)- and M(4)-receptor-deficient mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 365: 112-22. PMID 11819029 DOI: 10.1007/S00210-001-0517-7 |
0.522 |
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| 2002 |
Ward SD, Hamdan FF, Bloodworth LM, Wess J. Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy. The Journal of Biological Chemistry. 277: 2247-57. PMID 11698401 DOI: 10.1074/Jbc.M107647200 |
0.536 |
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| 2002 |
Wess J. Considerations in the design and use of chimeric G protein-coupled receptors. Methods in Enzymology. 343: 295-312. PMID 11665575 DOI: 10.1016/S0076-6879(02)43143-6 |
0.522 |
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| 2002 |
Zeng F, Soldner A, Schöneberg T, Wess J. Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling Journal of Neurochemistry. 72: 2404-2414. PMID 10349850 DOI: 10.1046/J.1471-4159.1999.0722404.X |
0.553 |
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| 2001 |
Berkeley JL, Gomeza J, Wess J, Hamilton SE, Nathanson NM, Levey AI. M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices. Molecular and Cellular Neurosciences. 18: 512-24. PMID 11922142 DOI: 10.1006/Mcne.2001.1042 |
0.499 |
|
| 2001 |
Yamada M, Lamping KG, Duttaroy A, Zhang W, Cui Y, Bymaster FP, McKinzie DL, Felder CC, Deng CX, Faraci FM, Wess J. Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 14096-101. PMID 11707605 DOI: 10.1073/Pnas.251542998 |
0.588 |
|
| 2001 |
Felder CC, Porter AC, Skillman TL, Zhang L, Bymaster FP, Nathanson NM, Hamilton SE, Gomeza J, Wess J, McKinzie DL. Elucidating the role of muscarinic receptors in psychosis. Life Sciences. 68: 2605-13. PMID 11392633 DOI: 10.1016/S0024-3205(01)01059-1 |
0.548 |
|
| 2001 |
Shapiro MS, Gomeza J, Hamilton SE, Hille B, Loose MD, Nathanson NM, Roche JP, Wess J. Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons. Life Sciences. 68: 2481-7. PMID 11392616 DOI: 10.1016/S0024-3205(01)01042-6 |
0.566 |
|
| 2001 |
Bymaster FP, Carter PA, Zhang L, Falcone JF, Stengel PW, Cohen ML, Shannon HE, Gomeza J, Wess J, Felder CC. Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice. Life Sciences. 68: 2473-9. PMID 11392615 DOI: 10.1016/S0024-3205(01)01041-4 |
0.57 |
|
| 2001 |
Gomeza J, Zhang L, Kostenis E, Felder CC, Bymaster FP, Brodkin J, Shannon H, Xia B, Duttaroy A, Deng Cx, Wess J. Generation and pharmacological analysis of M2 and M4 muscarinic receptor knockout mice Life Sciences. 68: 2457-2466. PMID 11392613 DOI: 10.1016/S0024-3205(01)01039-6 |
0.63 |
|
| 2001 |
Erlenbach I, Kostenis E, Schmidt C, Hamdan FF, Pausch MH, Wess J. Functional expression of M(1), M(3) and M(5) muscarinic acetylcholine receptors in yeast. Journal of Neurochemistry. 77: 1327-37. PMID 11389184 DOI: 10.1046/J.1471-4159.2001.00344.X |
0.578 |
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| 2001 |
Erlenbach I, Kostenis E, Schmidt C, Serradeil-Le Gal C, Raufaste D, Dumont ME, Pausch MH, Wess J. Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis. The Journal of Biological Chemistry. 276: 29382-92. PMID 11375990 DOI: 10.1074/Jbc.M103203200 |
0.489 |
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| 2001 |
Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R, Ogawa M, Chou CJ, Xia B, Crawley JN, Felder CC, Deng CX, Wess J. Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature. 410: 207-12. PMID 11242080 DOI: 10.1038/35065604 |
0.545 |
|
| 2001 |
Miyakawa T, Yamada M, Duttaroy A, Wess J. Hyperactivity and Intact Hippocampus-Dependent Learning in Mice Lacking the M1Muscarinic Acetylcholine Receptor The Journal of Neuroscience. 21: 5239-5250. DOI: 10.1523/Jneurosci.21-14-05239.2001 |
0.482 |
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| 2000 |
Yun J, Schöneberg T, Liu J, Schulz A, Ecelbarger CA, Promeneur D, Nielsen S, Sheng H, Grinberg A, Deng CX, Wess J. Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene. Journal of Clinical Investigation. 106: 1361-1371. PMID 11104789 DOI: 10.1172/Jci9154 |
0.371 |
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| 2000 |
Wess J. Physiological roles of G-protein-coupled receptor kinases revealed by gene-targeting technology. Trends in Pharmacological Sciences. 21: 364-7. PMID 11050310 DOI: 10.1016/S0165-6147(00)01542-X |
0.373 |
|
| 2000 |
Zeng F, Wess J. Molecular aspects of muscarinic receptor dimerization. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 23: S19-31. PMID 11008064 DOI: 10.1016/S0893-133X(00)00146-9 |
0.587 |
|
| 1999 |
Shapiro MS, Loose MD, Hamilton SE, Nathanson NM, Gomeza J, Wess J, Hille B. Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca(2+) channels by using knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 10899-904. PMID 10485923 DOI: 10.1073/pnas.96.19.10899 |
0.454 |
|
| 1999 |
Gomeza J, Zhang L, Kostenis E, Felder C, Bymaster F, Brodkin J, Shannon H, Xia B, Deng C, Wess J. Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 10483-8. PMID 10468635 DOI: 10.1073/Pnas.96.18.10483 |
0.626 |
|
| 1999 |
Zeng F, Wess J. Identification and Molecular Characterization of m3 Muscarinic Receptor Dimers Journal of Biological Chemistry. 274: 19487-19497. PMID 10383466 DOI: 10.1074/Jbc.274.27.19487 |
0.548 |
|
| 1999 |
Zeng F, Hopp A, Soldner A, Wess J. Use of a Disulfide Cross-linking Strategy to Study Muscarinic Receptor Structure and Mechanisms of Activation Journal of Biological Chemistry. 274: 16629-16640. PMID 10347230 DOI: 10.1074/Jbc.274.23.16629 |
0.52 |
|
| 1999 |
Wess J, Blin N, Mutschler E, Blüml K. Muscarinic acetylcholine receptors: structural basis of ligand binding and G protein coupling. Life Sciences. 56: 915-22. PMID 10188793 DOI: 10.1016/0024-3205(95)00028-5 |
0.555 |
|
| 1999 |
Kostenis E, Zeng F, Wess J. Structure-function analysis of muscarinic receptors and their associated G proteins Life Sciences. 64: 355-362. PMID 10069496 DOI: 10.1016/S0024-3205(98)00574-8 |
0.534 |
|
| 1999 |
Gomeza J, Shannon H, Kostenis E, Felder C, Zhang L, Brodkin J, Grinberg A, Sheng H, Wess J. Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 1692-7. PMID 9990086 DOI: 10.1073/Pnas.96.4.1692 |
0.623 |
|
| 1999 |
Wess J. Molecular basis of receptor/G-protein-coupling selectivity. Pharmacology & Therapeutics. 80: 231-64. PMID 9888696 DOI: 10.1016/S0163-7258(98)00030-8 |
0.445 |
|
| 1999 |
Jakubik J, Wess J. Use Of A Sandwich Enzyme-Linked Immunosorbent Assay Strategy To Study Mechanisms Of G Protein-Coupled Receptor Assembly Journal of Biological Chemistry. 274: 1349-1358. PMID 9880506 DOI: 10.1074/Jbc.274.3.1349 |
0.565 |
|
| 1999 |
Zeng F, Wess J. Development of a disulfide cross-linking strategy to study muscarinic receptor structure Life Sciences. 64: 565. DOI: 10.1016/S0024-3205(99)90485-X |
0.422 |
|
| 1998 |
Schöneberg T, Kostenis E, Liu J, Gudermann T, Wess J. Molecular aspects of vasopressin receptor function Advances in Experimental Medicine and Biology. 449: 347-358. PMID 10026824 DOI: 10.1007/978-1-4615-4871-3_44 |
0.485 |
|
| 1998 |
Zhu X, Wess J. Truncated V2 vasopressin receptors as negative regulators of wild-type V2 receptor function. Biochemistry. 37: 15773-15784. PMID 9843382 DOI: 10.1021/Bi981162Z |
0.476 |
|
| 1998 |
Erlenbach I, Wess J. Molecular Basis of V2 Vasopressin Receptor/GsCoupling Selectivity Journal of Biological Chemistry. 273: 26549-26558. PMID 9756892 DOI: 10.1074/Jbc.273.41.26549 |
0.484 |
|
| 1998 |
Kostenis E, Zeng F, Wess J. Functional Characterization of a Series of Mutant G Protein αq Subunits Displaying Promiscuous Receptor Coupling Properties Journal of Biological Chemistry. 273: 17886-17892. PMID 9651394 DOI: 10.1074/Jbc.273.28.17886 |
0.487 |
|
| 1997 |
Kostenis E, Gomeza J, Lerche C, Wess J. Genetic analysis of receptor-Galphaq coupling selectivity. The Journal of Biological Chemistry. 272: 23675-81. PMID 9295309 DOI: 10.1074/Jbc.272.38.23675 |
0.536 |
|
| 1997 |
Schöneberg T, Sandig V, Wess J, Gudermann T, Schultz G. Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer: Molecular basis and clinical implication Journal of Clinical Investigation. 100: 1547-1556. PMID 9294123 DOI: 10.1172/Jci119678 |
0.453 |
|
| 1997 |
Wess J, Liu J, Blin N, Yun J, Lerche C, Kostenis E. Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems. Life Sciences. 60: 1007-14. PMID 9121341 DOI: 10.1016/S0024-3205(97)00041-6 |
0.536 |
|
| 1997 |
Kostenis E, Conklin BR, Wess J. Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits. Biochemistry. 36: 1487-95. PMID 9063897 DOI: 10.1021/Bi962554D |
0.462 |
|
| 1997 |
Wess J, Blin N, Yun J, Schöneberg T, Liu J. Molecular aspects of muscarinic receptor assembly and function. Progress in Brain Research. 109: 153-62. PMID 9009702 DOI: 10.1016/S0079-6123(08)62097-X |
0.489 |
|
| 1997 |
Wess J. Molecular biology of muscarinic acetylcholine receptors. Critical Reviews in Neurobiology. 10: 69-99. PMID 8853955 DOI: 10.1615/Critrevneurobiol.V10.I1.40 |
0.464 |
|
| 1997 |
Hou X, Wehrle J, Menge W, Ciccarelli E, Wess J, Mutschler E, Lambrecht G, Timmerman H, Waelbroeck M. Influence of monovalent cations on the binding of a charged and an uncharged ('carbo'-)muscarinic antagonist to muscarinic receptors. British Journal of Pharmacology. 117: 955-61. PMID 8851517 DOI: 10.1111/J.1476-5381.1996.Tb15287.X |
0.516 |
|
| 1997 |
Wess J. G‐protein‐coupled receptors: molecular mechanisms involved in receptor activation and selectivity of G‐protein recognition The Faseb Journal. 11: 346-354. DOI: 10.1096/Fasebj.11.5.9141501 |
0.446 |
|
| 1996 |
Wenkert D, Schoneberg T, Merendino JJ, Rodriguez Pena MS, Vinitsky R, Goldsmith PK, Wess J, Spiegel AM. Functional characterization of five V2 vasopressin receptor gene mutations. Molecular and Cellular Endocrinology. 124: 43-50. PMID 9027323 DOI: 10.1016/S0303-7207(96)03926-3 |
0.422 |
|
| 1996 |
Singer-Lahat D, Liu J, Wess J, Felder CC. The third intracellular domain of the m3 muscarinic receptor determines coupling to calcium influx in transfected Chinese hamster ovary cells. Febs Letters. 386: 51-4. PMID 8635603 DOI: 10.1016/0014-5793(96)00398-5 |
0.536 |
|
| 1996 |
Liu J, Blin N, Conklin BR, Wess J. Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis. The Journal of Biological Chemistry. 271: 6172-8. PMID 8626406 DOI: 10.1074/Jbc.271.11.6172 |
0.564 |
|
| 1996 |
Liu J, Wess J. Different Single Receptor Domains Determine the Distinct G Protein Coupling Profiles of Members of the Vasopressin Receptor Family Journal of Biological Chemistry. 271: 8772-8778. PMID 8621513 DOI: 10.1074/Jbc.271.15.8772 |
0.487 |
|
| 1996 |
Schoneberg T, Yun J, Wenkert D, Wess J. Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co‐expressed receptor polypeptide. The Embo Journal. 15: 1283-1291. DOI: 10.1002/J.1460-2075.1996.Tb00470.X |
0.489 |
|
| 1995 |
Liu J, Conklin BR, Blin N, Yun J, Wess J. Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proceedings of the National Academy of Sciences of the United States of America. 92: 11642-6. PMID 8524820 DOI: 10.1073/Pnas.92.25.11642 |
0.501 |
|
| 1995 |
Kim J, Wess J, van Rhee AM, Schöneberg T, Jacobson KA. Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor. The Journal of Biological Chemistry. 270: 13987-97. PMID 7775460 DOI: 10.1074/Jbc.270.23.13987 |
0.446 |
|
| 1995 |
Mutschler E, Moser U, Wess J, Lambrecht G. Muscarinic receptor subtypes — pharmacological, molecular biological and therapeutical aspects Pharmaceutica Acta Helvetiae. 69: 243-258. PMID 7651968 DOI: 10.1016/0031-6865(94)00045-W |
0.475 |
|
| 1995 |
Liu J, Schöneberg T, Rhee Mv, Wess J. Mutational Analysis of the Relative Orientation of Transmembrane Helices I and VII in G Protein-coupled Receptors Journal of Biological Chemistry. 270: 19532-19539. PMID 7642637 DOI: 10.1074/Jbc.270.33.19532 |
0.561 |
|
| 1995 |
Schöneberg T, Liu J, Wess J. Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor Journal of Biological Chemistry. 270: 18000-18006. PMID 7629108 DOI: 10.1074/Jbc.270.30.18000 |
0.529 |
|
| 1995 |
Blin N, Wess J. Mapping of muscarinic receptor domains conferring specificity of coupling to Gq Life Sciences. 56: 1032. DOI: 10.1016/0024-3205(95)93776-B |
0.382 |
|
| 1994 |
Bluml K, Mutschler E, Wess J. Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling Proceedings of the National Academy of Sciences of the United States of America. 91: 7980-7984. PMID 8058746 DOI: 10.1073/Pnas.91.17.7980 |
0.496 |
|
| 1993 |
Wess J. Mutational analysis of muscarinic acetylcholine receptors: structural basis of ligand/receptor/G protein interactions. Life Sciences. 53: 1447-63. PMID 8412508 DOI: 10.1016/0024-3205(93)90618-D |
0.535 |
|
| 1993 |
Maggio R, Vogel Z, Wess J. Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors Proceedings of the National Academy of Sciences of the United States of America. 90: 3103-3107. PMID 8385357 DOI: 10.1073/Pnas.90.7.3103 |
0.56 |
|
| 1993 |
Wess J. Molecular basis of muscarinic acetylcholine receptor function. Trends in Pharmacological Sciences. 14: 308-13. PMID 8249149 DOI: 10.1016/0165-6147(93)90049-P |
0.549 |
|
| 1993 |
Vogel Z, Maggio R, Palmer J, Wess J. Conserved threonine and tyrosine residues play important roles in acetylcholine binding and muscarinic receptor activation Life Sciences. 52: 558. DOI: 10.1016/0024-3205(93)90333-X |
0.43 |
|
| 1993 |
Maggio R, Vogel Z, Nanavati S, Wess J. Coexpression of N- and C- terminal muscarinic receptor domains results in functional receptors Life Sciences. 52: 558. DOI: 10.1016/0024-3205(93)90332-W |
0.436 |
|
| 1993 |
Wess J, Nanavati S, Vogel Z, Maggio R. Mutational analysis of the m3 muscarinic receptor: Functional role of proline residues that are highly conserved among all G protein-coupled receptors Life Sciences. 52: 557. DOI: 10.1016/0024-3205(93)90331-V |
0.53 |
|
| 1992 |
Felder CC, Poulter MO, Wess J. Muscarinic receptor-operated Ca2+ influx in transfected fibroblast cells is independent of inositol phosphates and release of intracellular Ca2+. Proceedings of the National Academy of Sciences of the United States of America. 89: 509-13. PMID 1731321 DOI: 10.1073/PNAS.89.2.509 |
0.321 |
|
| 1991 |
Angeli P, Brasili L, Cantalamessa F, Marucci G, Wess J. Determination of muscarinic agonist potencies at M1 and M2 muscarinic receptors in a modified pithed rat preparation. Naunyn-Schmiedeberg's Archives of Pharmacology. 342: 625-9. PMID 2096296 DOI: 10.1007/BF00175704 |
0.477 |
|
| 1990 |
Mutschler E, Feifel R, Moser U, Tacke R, Wess J, Lambrecht G. Muscarinic receptor subtypes European Journal of Pharmacology. 183: 117-119. DOI: 10.1016/0014-2999(90)91384-N |
0.51 |
|
| 1988 |
Wess J, Angeli P, Melchiorre C, Moser U, Mutschler E, Lambrecht G. Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo. Naunyn-Schmiedeberg's Archives of Pharmacology. 338: 246-9. PMID 3057387 DOI: 10.1007/BF00173395 |
0.449 |
|
| 1988 |
Eltze M, Gmelin G, Wess J, Strohmann C, Tacke R, Mutschler E, Lambrecht G. Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type. European Journal of Pharmacology. 158: 233-242. PMID 2472963 DOI: 10.1016/0014-2999(88)90072-6 |
0.533 |
|
| 1986 |
Lambrecht G, Moser U, Mutschler E, Walther G, Wess J. Muscarinic ganglionic stimulants: conformationally restrained analogues related to [4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]trimethylammonium chloride. Journal of Medicinal Chemistry. 29: 1309-1311. PMID 3806582 DOI: 10.1021/Jm00157A036 |
0.396 |
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