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Randal Halfmann - Publications

Affiliations: 
Biology Stowers Instistute for Medical Research 
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kandola T, Venkatesan S, Zhang J, Lerbakken BT, Von Schulze A, Blanck JF, Wu J, Unruh JR, Berry P, Lange JJ, Box AC, Cook M, Sagui C, Halfmann R. Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal. Elife. 12. PMID 37921648 DOI: 10.7554/eLife.86939  0.762
2023 Kandola T, Venkatesan S, Zhang J, Lerbakken B, Schulze AV, Blanck JF, Wu J, Unruh J, Berry P, Lange JJ, Box A, Cook M, Sagui C, Halfmann R. Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal. Biorxiv : the Preprint Server For Biology. PMID 36993401 DOI: 10.1101/2023.03.20.533418  0.759
2023 Rodriguez Gama A, Miller T, Lange JJ, Wu J, Song X, Venkatesan S, Unruh JR, Bradford D, Halfmann R. Protein supersaturation powers innate immune signaling. Biorxiv : the Preprint Server For Biology. PMID 36993308 DOI: 10.1101/2023.03.20.533581  0.755
2023 Miller T, Wu J, Venkatesan S, Gama AR, Halfmann R. DAmFRET measures saturating concentrations and toxicities of protein phase transitions in vivo. Molecular Biology of the Cell. mbcE22110503. PMID 36920097 DOI: 10.1091/mbc.E22-11-0503  0.798
2022 Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R. A nucleation barrier spring-loads the CBM signalosome for binary activation. Elife. 11. PMID 35727133 DOI: 10.7554/eLife.79826  0.322
2021 Posey AE, Ruff KM, Lalmansingh JM, Kandola TS, Lange JJ, Halfmann R, Pappu RV. Mechanistic inferences from analysis of measurements of protein phase transitions in live cells. Journal of Molecular Biology. 166848. PMID 33539877 DOI: 10.1016/j.jmb.2021.166848  0.791
2020 Nuckolls NL, Mok AC, Lange JJ, Yi K, Kandola TS, Hunn AM, McCroskey S, Snyder JL, Bravo Núñez MA, McClain M, McKinney SA, Wood C, Halfmann R, Zanders SE. The meiotic driver utilizes controlled protein aggregation to generate selective cell death. Elife. 9. PMID 33108274 DOI: 10.7554/eLife.55694  0.797
2020 Halfmann R, Venkatesan S, Wu J. Translation Initiation Rates Govern Protein Self‐Assembly In Vivo The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07306  0.759
2020 Wu J, Halfmann R. Competing modes of assembly restrict amyloid formation by a neurodegenerative protein, TDP43 The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05411  0.426
2020 Lalmansingh JM, Posey AE, Kandola T, Halfmann R, Pappu RV. Basin Mapping Method for Extracting Comparative Assessments of Protein Phase Behavior from In Vivo Measurements Biophysical Journal. 118: 538a. DOI: 10.1016/J.Bpj.2019.11.2949  0.766
2019 Venkatesan S, Kandola TS, Rodríguez-Gama A, Box A, Halfmann R. Detecting and Characterizing Protein Self-Assembly In Vivo by Flow Cytometry. Journal of Visualized Experiments : Jove. PMID 31380843 DOI: 10.3791/59577  0.76
2019 Holliday MJ, Witt A, Rodríguez Gama A, Walters BT, Arthur CP, Halfmann R, Rohou A, Dueber EC, Fairbrother WJ. Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation. Nature Communications. 10: 3070. PMID 31296852 DOI: 10.2210/Pdb6N2P/Pdb  0.356
2019 Khan T, Kandola TS, Wu J, Venkatesan S, Ketter E, Lange JJ, Gama AR, Box A, Unruh JR, Cook M, Halfmann R. Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior. Molecular Cell. 73: 857. PMID 30794793 DOI: 10.1016/j.molcel.2019.01.045  0.71
2018 Khan T, Kandola TS, Wu J, Venkatesan S, Ketter E, Lange JJ, Rodríguez Gama A, Box A, Unruh JR, Cook M, Halfmann R. Quantifying Nucleation In Vivo Reveals the Physical Basis of Prion-like Phase Behavior. Molecular Cell. 71: 155-168.e7. PMID 29979963 DOI: 10.1016/J.Molcel.2018.06.016  0.758
2018 Posey AE, Kandola T, Pappu RV, Halfmann R. Advances in Quantitative Analysis of Intracellular Protein Phase Separation Kinetics and its Modulation by Cellular Interactions Biophysical Journal. 114: 588a. DOI: 10.1016/J.Bpj.2017.11.3219  0.777
2017 Zhang XF, Sun R, Guo Q, Zhang S, Meulia T, Halfmann R, Li D, Qu F. A self-perpetuating repressive state of a viral replication protein blocks superinfection by the same virus. Plos Pathogens. 13: e1006253. PMID 28267773 DOI: 10.1371/Journal.Ppat.1006253  0.309
2016 Halfmann R. A glass menagerie of low complexity sequences. Current Opinion in Structural Biology. 38: 18-25. PMID 27258703 DOI: 10.1016/J.Sbi.2016.05.002  0.424
2014 Close DW, Paul CD, Langan PS, Wilce MC, Traore DA, Halfmann R, Rocha RC, Waldo GS, Payne RJ, Rucker JB, Prescott M, Bradbury AR. Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering. Proteins. PMID 25287913 DOI: 10.1002/Prot.24699  0.4
2014 Cai X, Chen J, Xu H, Liu S, Jiang QX, Halfmann R, Chen ZJ. Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell. 156: 1207-22. PMID 24630723 DOI: 10.1016/J.Cell.2014.01.063  0.308
2013 Holmes DL, Lancaster AK, Lindquist S, Halfmann R. Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Cell. 153: 153-65. PMID 23540696 DOI: 10.1016/J.Cell.2013.02.026  0.588
2012 Halfmann R, Wright JR, Alberti S, Lindquist S, Rexach M. Prion formation by a yeast GLFG nucleoporin. Prion. 6: 391-9. PMID 22561191 DOI: 10.4161/pri.20199  0.624
2012 Halfmann R, Jarosz DF, Jones SK, Chang A, Lancaster AK, Lindquist S. Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature. 482: 363-8. PMID 22337056 DOI: 10.1038/Nature10875  0.71
2011 Halfmann R, Alberti S, Krishnan R, Lyle N, O'Donnell CW, King OD, Berger B, Pappu RV, Lindquist S. Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Molecular Cell. 43: 72-84. PMID 21726811 DOI: 10.1016/J.Molcel.2011.05.013  0.622
2011 O'Donnell CW, Waldispühl J, Lis M, Halfmann R, Devadas S, Lindquist S, Berger B. A method for probing the mutational landscape of amyloid structure Bioinformatics. 27: i34-i42. PMID 21685090 DOI: 10.1093/bioinformatics/btr238  0.516
2010 Halfmann R, Lindquist S. Epigenetics in the extreme: Prions and the inheritance of environmentally acquired traits Science. 330: 629-632. PMID 21030648 DOI: 10.1126/Science.1191081  0.567
2010 Alberti S, Halfmann R, Lindquist S. Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast. Methods in Enzymology. 470: 709-34. PMID 20946833 DOI: 10.1016/S0076-6879(10)70030-6  0.621
2010 Halfmann R, Alberti S, Lindquist S. Prions, protein homeostasis, and phenotypic diversity. Trends in Cell Biology. 20: 125-33. PMID 20071174 DOI: 10.1016/j.tcb.2009.12.003  0.55
2009 Alberti S, Halfmann R, King O, Kapila A, Lindquist S. A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell. 137: 146-58. PMID 19345193 DOI: 10.1016/J.Cell.2009.02.044  0.63
2008 Halfmann R, Lindquist S. Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis. Journal of Visualized Experiments : Jove. PMID 19066511 DOI: 10.3791/838  0.634
2008 Douglas PM, Treusch S, Ren HY, Halfmann R, Duennwald ML, Lindquist S, Cyr DM. Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 7206-11. PMID 18480252 DOI: 10.1073/Pnas.0802593105  0.782
2008 Halfmann R, Lindquist S. Screening for amyloid aggregation by semi-denaturing detergent-agarose gel electrophoresis Journal of Visualized Experiments. DOI: 10.3791/838  0.477
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