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Joshua Levitz - Publications

Affiliations: 
Biochemistry Weill Cornell Medicine 
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lao-Peregrin C, Xiang G, Kim J, Srivastava I, Fall AB, Gerhard DM, Kohtala P, Kim D, Song M, Garcia-Marcos M, Levitz J, Lee FS. Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk. Cell Reports. 43: 113595. PMID 38117654 DOI: 10.1016/j.celrep.2023.113595  0.49
2023 Lee J, Gonzalez-Hernandez AJ, Kristt M, Abreu N, Roßmann K, Arefin A, Marx DC, Broichhagen J, Levitz J. Distinct beta-arrestin coupling and intracellular trafficking of metabotropic glutamate receptor homo- and heterodimers. Science Advances. 9: eadi8076. PMID 38055809 DOI: 10.1126/sciadv.adi8076  0.43
2023 Menon I, Sych T, Son Y, Morizumi T, Lee J, Ernst OP, Khelashvili G, Sezgin E, Levitz J, Menon AK. A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. Biorxiv : the Preprint Server For Biology. PMID 38045315 DOI: 10.1101/2023.11.24.568580  0.34
2023 Luebbers A, Gonzalez-Hernandez AJ, Zhou M, Eyles SJ, Levitz J, Garcia-Marcos M. Dissecting the molecular basis for the modulation of neurotransmitter GPCR signaling by GINIP. Structure (London, England : 1993). PMID 37989308 DOI: 10.1016/j.str.2023.10.010  0.825
2023 Lao-Peregrin C, Xiang G, Kim J, Srivastava I, Fall AB, Gerhard DM, Kohtala P, Kim D, Song M, Garcia-Marcos M, Levitz J, Lee FS. Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk. Biorxiv : the Preprint Server For Biology. PMID 37693535 DOI: 10.1101/2023.08.28.555210  0.493
2023 Mancinelli C, Marx DC, Gonzalez-Hernandez AJ, Mancinelli L, Khelashvilli G, Levitz J, Eliezer D. Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. Biorxiv : the Preprint Server For Biology. PMID 37645938 DOI: 10.1101/2023.08.16.553551  0.803
2023 Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J. Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization. Biorxiv : the Preprint Server For Biology. PMID 37645747 DOI: 10.1101/2023.08.13.552748  0.785
2022 Xiang G, Acosta-Ruiz A, Radoux-Mergault A, Kristt M, Kim J, Moon JD, Broichhagen J, Inoue A, Lee FS, Stoeber M, Dittman JS, Levitz J. Control of Gα signaling dynamics and GPCR cross-talk by GRKs. Science Advances. 8: eabq3363. PMID 36427324 DOI: 10.1126/sciadv.abq3363  0.425
2022 Birke R, Ast J, Roosen DA, Lee J, Roßmann K, Huhn C, Mathes B, Lisurek M, Bushiri D, Sun H, Jones B, Lehmann M, Levitz J, Haucke V, Hodson DJ, et al. Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins. Organic & Biomolecular Chemistry. PMID 35188523 DOI: 10.1039/d1ob02216d  0.421
2022 Morstein J, Romano G, Hetzler B, Plante A, Haake C, Levitz J, Trauner D. Photoswitchable Serotonins for Optical Control of the 5-HT2A Receptor. Angewandte Chemie (International Ed. in English). PMID 34989082 DOI: 10.1002/anie.202117094  0.444
2021 Selvakumar P, Lee J, Khanra N, He C, Munguba H, Kiese L, Broichhagen J, Reiner A, Levitz J, Meyerson JR. Structural and compositional diversity in the kainate receptor family. Cell Reports. 37: 109891. PMID 34706237 DOI: 10.1016/j.celrep.2021.109891  0.661
2021 Khelashvili G, Pillai AN, Lee J, Pandey K, Payne AM, Siegel Z, Cuendet MA, Lewis TR, Arshavsky VY, Broichhagen J, Levitz J, Menon AK. Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin. Scientific Reports. 11: 10536. PMID 34006992 DOI: 10.1038/s41598-021-90039-3  0.414
2021 Abreu N, Acosta-Ruiz A, Xiang G, Levitz J. Mechanisms of differential desensitization of metabotropic glutamate receptors. Cell Reports. 35: 109050. PMID 33910009 DOI: 10.1016/j.celrep.2021.109050  0.826
2021 Thibado JK, Tano JY, Lee J, Salas-Estrada L, Provasi D, Strauss A, Marcelo Lamim Ribeiro J, Xiang G, Broichhagen J, Filizola M, Lohse MJ, Levitz J. Differences in interactions between transmembrane domains tune the activation of metabotropic glutamate receptors. Elife. 10. PMID 33880992 DOI: 10.7554/eLife.67027  0.568
2021 Gutzeit VA, Acosta-Ruiz A, Munguba H, Häfner S, Landra-Willm A, Mathes B, Mony J, Yarotski D, Börjesson K, Liston C, Sandoz G, Levitz J, Broichhagen J. A fine-tuned azobenzene for enhanced photopharmacology in vivo. Cell Chemical Biology. PMID 33735619 DOI: 10.1016/j.chembiol.2021.02.020  0.807
2020 Poc P, Gutzeit VA, Ast J, Lee J, Jones BJ, D'Este E, Mathes B, Lehmann M, Hodson DJ, Levitz J, Broichhagen J. Interrogating surface intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates. Chemical Science. 11: 7871-7883. PMID 34123074 DOI: 10.1039/d0sc02794d  0.802
2020 Ellaithy A, Gonzalez-Maeso J, Logothetis DA, Levitz J. Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function. Trends in Biochemical Sciences. PMID 32861513 DOI: 10.1016/J.Tibs.2020.07.008  0.589
2020 Abreu N, Levitz J. Optogenetic Techniques for Manipulating and Sensing G Protein-Coupled Receptor Signaling. Methods in Molecular Biology (Clifton, N.J.). 2173: 21-51. PMID 32651908 DOI: 10.1007/978-1-0716-0755-8_2  0.823
2020 Lee J, Munguba H, Gutzeit VA, Singh DR, Kristt M, Dittman JS, Levitz J. Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors. Cell Reports. 31: 107891. PMID 32610118 DOI: 10.1016/j.celrep.2020.107891  0.822
2020 Lee J, Munguba H, Gutzeit VA, Kristt M, Dittman JS, Levitz J. Defining the Homo- and Heterodimerization Propensities of Metabotropic Glutamate Receptors. Cell Reports. 31: 107605. PMID 32375054 DOI: 10.1016/J.Celrep.2020.107605  0.817
2020 Gutzeit VA, Ruiz AA, Kristt M, Liston C, Broichhagen J, Levitz J. Branched Photoswitchable Tethered Ligands for Optical Interrogation of Metabotropic Glutamate Receptor‐Mediated Modulation of Prefrontal Cortex Circuits The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05430  0.76
2020 Poc P, Gutzeit VA, Ast J, Lee J, Jones BJ, D'Este E, Mathes B, Lehmann M, Hodson DJ, Levitz J, Broichhagen J. Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates Chemical Science. 11: 7871-7883. DOI: 10.1039/D0Sc02794D  0.79
2019 Habrian CH, Levitz J, Vyklicky V, Fu Z, Hoagland A, McCort-Tranchepain I, Acher F, Isacoff EY. Conformational pathway provides unique sensitivity to a synaptic mGluR. Nature Communications. 10: 5572. PMID 31804469 DOI: 10.1038/S41467-019-13407-8  0.834
2019 Acosta-Ruiz A, Gutzeit VA, Skelly MJ, Meadows S, Lee J, Parekh P, Orr AG, Liston C, Pleil KE, Broichhagen J, Levitz J. Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo. Neuron. PMID 31784287 DOI: 10.1016/J.Neuron.2019.10.036  0.842
2019 Donthamsetti PC, Broichhagen J, Vyklicky V, Stanley C, Fu Z, Visel M, Levitz JL, Javitch JA, Trauner D, Isacoff EY. Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor. Journal of the American Chemical Society. PMID 31291105 DOI: 10.1021/Jacs.9B02895  0.7
2019 Gutzeit VA, Thibado J, Stor DS, Zhou Z, Blanchard SC, Andersen OS, Levitz J. Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor. Elife. 8. PMID 31172948 DOI: 10.7554/Elife.45116  0.835
2019 Acosta-Ruiz A, Broichhagen J, Levitz J. Optical Regulation of Class C GPCRs by Photoswitchable Orthogonal Remotely Tethered Ligands. Methods in Molecular Biology (Clifton, N.J.). 1947: 103-136. PMID 30969413 DOI: 10.1007/978-1-4939-9121-1_6  0.56
2019 Berry MH, Holt A, Salari A, Veit J, Visel M, Levitz J, Aghi K, Gaub BM, Sivyer B, Flannery JG, Isacoff EY. Restoration of high-sensitivity and adapting vision with a cone opsin. Nature Communications. 10: 1221. PMID 30874546 DOI: 10.1038/S41467-019-09124-X  0.747
2019 Zheng S, Abreu N, Levitz J, Kruse AC. Structural basis for KCTD-mediated rapid desensitization of GABA signalling. Nature. 567: 127-131. PMID 30814734 DOI: 10.1038/S41586-019-0990-0  0.811
2019 Gutzeit VA, Thibado J, Stor DS, Zhou Z, Blanchard SC, Andersen OS, Levitz J. Author response: Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor Elife. DOI: 10.7554/Elife.45116.029  0.812
2018 Farrants H, Gutzeit VA, Acosta Ruiz A, Trauner D, Johnsson K, Levitz J, Broichhagen J. SNAP-tagged nanobodies enable reversible optical control of a G protein-coupled receptor via a remotely tethered photoswitchable ligand. Acs Chemical Biology. PMID 30141622 DOI: 10.1021/Acschembio.8B00628  0.845
2018 Reiner A, Levitz J. Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert. Neuron. 98: 1080-1098. PMID 29953871 DOI: 10.1016/J.Neuron.2018.05.018  0.712
2018 Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Cao K, Kramer RH, Trauner D, Flannery J, Isacoff EY. Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nature Communications. 9: 1112. PMID 29535310 DOI: 10.1038/S41467-018-03585-2  0.771
2017 Pandey K, Ploier B, Goren MA, Levitz J, Khelashvili G, Menon AK. An engineered opsin monomer scrambles phospholipids. Scientific Reports. 7: 16741. PMID 29196630 DOI: 10.1038/S41598-017-16842-Z  0.384
2017 Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Trauner D, Flannery J, Isacoff EY. Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nature Communications. 8: 1862. PMID 29192252 DOI: 10.1038/S41467-017-01990-7  0.8
2017 Donthamsetti P, Winter N, Schönberger M, Levitz J, Stanley C, Javitch JA, Isacoff EY, Trauner D. Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist. Journal of the American Chemical Society. PMID 29166564 DOI: 10.1021/Jacs.7B07659  0.668
2017 Levitz J, Broichhagen J, Leippe P, Konrad D, Trauner D, Isacoff EY. Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396447 DOI: 10.1073/Pnas.1619652114  0.737
2016 Barber DM, Schönberger M, Burgstaller J, Levitz J, Weaver CD, Isacoff EY, Baier H, Trauner D. Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO). Chemical Science. 7: 2347-2352. PMID 28090283 DOI: 10.1039/C5Sc04084A  0.601
2016 Levitz J, Habrian C, Bharill S, Fu Z, Vafabakhsh R, Isacoff EY. Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors. Neuron. PMID 27641494 DOI: 10.1016/J.Neuron.2016.08.036  0.747
2016 Levitz J, Royal P, Comoglio Y, Wdziekonski B, Schaub S, Clemens DM, Isacoff EY, Sandoz G. Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035963 DOI: 10.1073/Pnas.1522459113  0.54
2016 Levitz J, Popescu AT, Reiner A, Isacoff EY. A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors. Frontiers in Molecular Neuroscience. 9: 2. PMID 26869877 DOI: 10.3389/Fnmol.2016.00002  0.78
2015 Broichhagen J, Damijonaitis A, Levitz J, Sokol KR, Leippe P, Konrad D, Isacoff EY, Trauner D. Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand. Acs Central Science. 1: 383-93. PMID 27162996 DOI: 10.1021/Acscentsci.5B00260  0.731
2015 Vafabakhsh R, Levitz J, Isacoff EY. Conformational dynamics of a class C G-protein-coupled receptor. Nature. 524: 497-501. PMID 26258295 DOI: 10.1038/Nature14679  0.709
2015 Carroll EC, Berlin S, Levitz J, Kienzler MA, Yuan Z, Madsen D, Larsen DS, Isacoff EY. Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. Proceedings of the National Academy of Sciences of the United States of America. 112: E776-85. PMID 25653339 DOI: 10.1073/Pnas.1416942112  0.664
2015 Reiner A, Levitz J, Isacoff EY. Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential. Current Opinion in Pharmacology. 20: 135-43. PMID 25573450 DOI: 10.1016/J.Coph.2014.12.008  0.777
2015 Vafabakhsh R, Levitz J, Isacoff EY. Confrontational Dynamics of a GPCR Revealed by Single Molecule FRET Biophysical Journal. 108: 3-9. DOI: 10.1016/J.Bpj.2014.11.1915  0.71
2014 Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff EY, Sandoz G. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America. 111: 13547-52. PMID 25197053 DOI: 10.1073/Pnas.1407160111  0.55
2014 Kienzler M, Levitz J, Isacoff E. Expanding the Visible Light Photoswitch Library: A Red-Shifted, Fast-Relaxing Azobenzene Photoswitch for Reversible Activation of Metabotropic Glutamate Receptors Biophysical Journal. 106: 380a-381a. DOI: 10.1016/J.Bpj.2013.11.2154  0.691
2014 Vafabakhsh R, Levitz J, Isacoff EY. The Activation Dynamics of Class C Gpcrs Revealed by Single Molecule FRET Biophysical Journal. 106: 194a. DOI: 10.1016/J.Bpj.2013.11.1149  0.721
2013 Reiner A, Levitz J, Isacoff E. Bringing optogenetics to the synapse. Neuron. 79: 209-10. PMID 23889927 DOI: 10.1016/J.Neuron.2013.07.009  0.667
2013 Sandoz G, Levitz J. Optogenetic techniques for the study of native potassium channels. Frontiers in Molecular Neuroscience. 6: 6. PMID 23596388 DOI: 10.3389/Fnmol.2013.00006  0.318
2013 Levitz J, Pantoja C, Gaub B, Janovjak H, Reiner A, Hoagland A, Schoppik D, Kane B, Stawski P, Schier AF, Trauner D, Isacoff EY. Optical control of metabotropic glutamate receptors. Nature Neuroscience. 16: 507-16. PMID 23455609 DOI: 10.1038/Nn.3346  0.835
2012 Sandoz G, Levitz J, Kramer RH, Isacoff EY. Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron. 74: 1005-14. PMID 22726831 DOI: 10.1016/J.Neuron.2012.04.026  0.613
2011 Levitz J, Gaub B, Janovjak H, Stawski P, Trauner D, Isacoff EY. Design and Application of a Light-Activated Metabotropic Glutamate Receptor for Optical Control of Intracellular Signaling Pathways Biophysical Journal. 100: 177a. DOI: 10.1016/J.Bpj.2010.12.1188  0.714
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