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George A Gutman - Publications

Affiliations: 
University of California, Irvine, Irvine, CA 
Area:
Antibody genes, Potassium Channels
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, ... ... Gutman GA, et al. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3952-64. PMID 24891519 DOI: 10.1096/Fj.14-251967  0.371
2014 Nguyen HM, Chhabra S, Chang SC, Huq RU, Tanner MR, Londono LM, Gindin M, Hotez PJ, Mohanty B, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. Kv1.3-Blocking Peptides from Parasitic Worms Exhibit Immunomodulatory Function Biophysical Journal. 106: 739a. DOI: 10.1016/J.Bpj.2013.11.4073  0.357
2009 Harmar AJ, Hills RA, Rosser EM, Jones M, Buneman OP, Dunbar DR, Greenhill SD, Hale VA, Sharman JL, Bonner TI, Catterall WA, Davenport AP, Delagrange P, Dollery CT, Foord SM, ... Gutman GA, et al. IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. Nucleic Acids Research. 37: D680-5. PMID 18948278 DOI: 10.1093/Nar/Gkn728  0.364
2008 Jang GM, Tanaka BS, Gutman GA, Goldin AL, Semler BL. Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression. Gene. 408: 133-45. PMID 18077107 DOI: 10.1016/J.Gene.2007.10.029  0.368
2006 Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, ... ... Gutman GA, et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America. 103: 17414-9. PMID 17088564 DOI: 10.1073/Pnas.0605136103  0.331
2005 Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels Pharmacological Reviews. 57: 463-472. PMID 16382103 DOI: 10.1124/Pr.57.4.9  0.445
2005 Yu FH, Yarov-Yarovoy V, Gutman GA, Catterall WA. Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacological Reviews. 57: 387-95. PMID 16382097 DOI: 10.1124/Pr.57.4.13  0.338
2005 Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG. Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases. Molecular Pharmacology. 67: 1369-81. PMID 15665253 DOI: 10.1124/Mol.104.008193  0.373
2005 Catterall WA, Gutman G. Introduction to the IUPHAR Compendium of Voltage-Gated Ion Channels 2005 Pharmacological Reviews. 57: 385. DOI: 10.1124/Pr.57.4.14  0.391
2004 Jang GM, Leong LE, Hoang LT, Wang PH, Gutman GA, Semler BL. Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA. The Journal of Biological Chemistry. 279: 47419-30. PMID 15339906 DOI: 10.1074/Jbc.M405885200  0.362
2004 Chandy KG, Wulff H, Beeton C, Pennington M, Gutman GA, Cahalan MD. K+ channels as targets for specific immunomodulation. Trends in Pharmacological Sciences. 25: 280-9. PMID 15120495 DOI: 10.1016/J.Tips.2004.03.010  0.434
2004 Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG. Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia. The Journal of Clinical Investigation. 113: 582-90. PMID 14966567 DOI: 10.1172/Jci200420216  0.32
2004 Kolski-Andreaco A, Tomita H, Shakkottai VG, Gutman GA, Cahalan MD, Gargus JJ, Chandy KG. SK3-1C, a dominant-negative suppressor of SKCa and IKCa channels. The Journal of Biological Chemistry. 279: 6893-904. PMID 14638680 DOI: 10.1074/Jbc.M311725200  0.424
2003 Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacological Reviews. 55: 583-6. PMID 14657415 DOI: 10.1124/Pr.55.4.9  0.413
2003 Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gargus JJ. Novel truncated isoform of SK3 potassium channel is a potent dominant-negative regulator of SK currents: implications in schizophrenia. Molecular Psychiatry. 8: 524-35, 460. PMID 12808432 DOI: 10.1038/Sj.Mp.4001271  0.405
2003 Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG. A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes. The Journal of Biological Chemistry. 278: 9928-37. PMID 12511563 DOI: 10.1074/Jbc.M212868200  0.448
2003 Catterall WA, Chandy KG, Clapham DE, Gutman GA, Hofmann F, Harmar AJ, Abernethy DR, Spedding M. International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels Pharmacological Reviews. 55: 573-574. DOI: 10.1124/Pr.55.4.5  0.365
2003 Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gargus JJ. Erratum: Naturally occurring dominant-negative SK3 channel isoform Molecular Psychiatry. 8: 766-766. DOI: 10.1038/Sj.Mp.4001407  0.361
2003 Tomita H, Shakkottai VG, Gutman GA, Sun G, Bunney WE, Cahalan MD, Chandy KG, Gamrgus JJ. Naturally occurring dominant-negative SK3 channel isoform Molecular Psychiatry. 8: 460. DOI: 10.1038/Sj.Mp.4001358  0.417
2001 Wulff H, Gutman GA, Cahalan MD, Chandy KG. Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. The Journal of Biological Chemistry. 276: 32040-5. PMID 11425865 DOI: 10.1074/Jbc.M105231200  0.401
2001 Miller MJ, Rauer H, Tomita H, Rauer H, Gargus JJ, Gutman GA, Cahalan MD, Chandy KG. Nuclear localization and dominant-negative suppression by a mutant SKCa3 N-terminal channel fragment identified in a patient with schizophrenia. The Journal of Biological Chemistry. 276: 27753-6. PMID 11395478 DOI: 10.1074/Jbc.C100221200  0.402
2001 Chandy KG, Cahalan M, Pennington M, Norton RS, Wulff H, Gutman GA. Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. Toxicon : Official Journal of the International Society On Toxinology. 39: 1269-76. PMID 11384714 DOI: 10.1016/S0041-0101(01)00120-9  0.402
2000 Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. The Journal of Biological Chemistry. 275: 37137-49. PMID 10961988 DOI: 10.1074/Jbc.M003941200  0.446
1999 Tytgat J, Chandy KG, Garcia ML, Gutman GA, Martin-Eauclaire MF, van der Walt JJ, Possani LD. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends in Pharmacological Sciences. 20: 444-7. PMID 10542442 DOI: 10.1016/S0165-6147(99)01398-X  0.306
1999 Dror V, Shamir E, Ghanshani S, Kimhi R, Swartz M, Barak Y, Weizman R, Avivi L, Litmanovitch T, Fantino E, Kalman K, Jones EG, Chandy KG, Gargus JJ, Gutman GA, et al. hKCa3/KCNN3 potassium channel gene: association of longer CAG repeats with schizophrenia in Israeli Ashkenazi Jews, expression in human tissues and localization to chromosome 1q21. Molecular Psychiatry. 4: 254-60. PMID 10395215 DOI: 10.1038/Sj.Mp.4000508  0.355
1999 Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. British Journal of Pharmacology. 126: 1707-16. PMID 10372812 DOI: 10.1038/Sj.Bjp.0702480  0.438
1998 Gargus JJ, Fantino E, Gutman GA. A piece in the puzzle: an ion channel candidate gene for schizophrenia Molecular Medicine Today. 4: 518-524. PMID 9866821 DOI: 10.1016/S1357-4310(98)01358-6  0.427
1998 Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide. The Journal of Biological Chemistry. 273: 32697-707. PMID 9830012 DOI: 10.1074/Jbc.273.49.32697  0.407
1998 Li T, Hu X, Chandy KG, Fantino E, Kalman K, Gutman G, Gargus JJ, Freeman B, Murray RM, Dawson E, Liu X, Bruinvels AT, Sham PC, Collier DA. Transmission disequilibrium analysis of a triplet repeat within the hKCa3 gene using family trios with schizophrenia. Biochemical and Biophysical Research Communications. 251: 662-5. PMID 9792831 DOI: 10.1006/Bbrc.1998.9484  0.315
1998 Ghanshani S, Coleman M, Gustavsson P, Wu AC, Gargus JJ, Gutman GA, Dahl N, Mohrenweiser H, Chandy KG. Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia. Genomics. 51: 160-1. PMID 9693050 DOI: 10.1006/Geno.1998.5333  0.36
1998 Negulescu D, Leong LE, Chandy KG, Semler BL, Gutman GA. Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry. The Journal of Biological Chemistry. 273: 20109-13. PMID 9685353 DOI: 10.1074/Jbc.273.32.20109  0.404
1998 Bowen T, Guy CA, Craddock N, Cardno AG, Williams NM, Spurlock G, Murphy KC, Jones LA, Gray M, Sanders RD, McCarthy G, Chandy KG, Fantino E, Kalman K, Gutman GA, et al. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia Molecular Psychiatry. 3: 266-269. PMID 9672903 DOI: 10.1038/Sj.Mp.4000400  0.329
1997 Spencer RH, Sokolov Y, Li H, Takenaka B, Milici AJ, Aiyar J, Nguyen A, Park H, Jap BK, Hall JE, Gutman GA, George Chandy K. Purification, visualization, and biophysical characterization of Kv1.3 tetramers Journal of Biological Chemistry. 272: 2389-2395. PMID 8999950 DOI: 10.1074/Jbc.272.4.2389  0.406
1997 Simon M, Conley EC, Shelton PA, Gutman GA, Chandy G. Transcription of the T-Cell Potassium Channel Kv1.3 Is Regulated by a GC-Rich TATA-Less Promoter Cellular Physiology and Biochemistry. 7: 243-250. DOI: 10.1159/000154879  0.434
1997 Chandy G, Strong M, Aiyar J, Gutman GA. Structural and Biochemical Features of the Kv1.3 Potassium Channel: An Aid to Guided Drug Design Cellular Physiology and Biochemistry. 7: 135-147. DOI: 10.1159/000154868  0.393
1996 Wymore RS, Negulescu D, Kinoshita K, Kalman K, Aiyar J, Gutman GA, Chandy KG. Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene. The Journal of Biological Chemistry. 271: 15629-34. PMID 8663090 DOI: 10.1074/Jbc.271.26.15629  0.388
1994 Chandy KG, Gutman GA. Nomenclature for mammalian potassium channel genes. Trends in Pharmacological Sciences. 14: 434. PMID 8122319 DOI: 10.1016/0165-6147(93)90181-I  0.437
1994 Wymore RS, Korenberg JR, Kinoshita KD, Aiyar J, Coyne C, Chen XN, Hustad CM, Copeland NG, Gutman GA, Jenkins NA. Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13. Genomics. 20: 191-202. PMID 8020965 DOI: 10.1006/Geno.1994.1153  0.417
1993 Spencer RH, Chandy KG, Gutman GA. Immunological identification of the Shaker-related Kv1.3 potassium channel protein in T and B lymphocytes, and detection of related proteins in files and yeast. Biochemical and Biophysical Research Communications. 191: 201-6. PMID 8447822 DOI: 10.1006/Bbrc.1993.1203  0.403
1993 Strong M, Chandy KG, Gutman GA. Molecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability. Molecular Biology and Evolution. 10: 221-42. PMID 7680747 DOI: 10.1093/Oxfordjournals.Molbev.A039986  0.459
1993 Strong M, Gutman GA. Missing link in ion channels. Nature. 362: 26-26. PMID 7680430 DOI: 10.1038/362026B0  0.369
1993 Chandy KG, Gutman GA, Grissmer S. Physiological role, molecular structure and evolutionary relationships of voltage-gated potassium channels in T lymphocytes Seminars in Neuroscience. 5: 125-134. DOI: 10.1016/S1044-5765(05)80007-7  0.448
1993 Gutman GA, Chandy KG. Nomenclature of mammalian voltage-dependent potassium channel genes Seminars in Neuroscience. 5: 101-106. DOI: 10.1016/S1044-5765(05)80004-1  0.432
1992 Ghanshani S, Pak M, McPherson JD, Strong M, Dethlefs B, Wasmuth JJ, Salkoff L, Gutman GA, Chandy KG. Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 12: 190-6. PMID 1740329 DOI: 10.1016/0888-7543(92)90365-Y  0.391
1992 Aguilar BA, Gutman GA. Transcription and diversity of immunoglobulin lambda chain variable genes in the rat. Immunogenetics. 37: 39-48. PMID 1428010 DOI: 10.1007/Bf00223543  0.333
1992 Blankenhorn EP, Smith PD, Williams CB, Gutman GA. Alleles of the rat T-cell receptor beta chain gene complex. Immunogenetics. 35: 324-31. PMID 1348495 DOI: 10.1007/Bf00189895  0.353
1990 Chandy KG, Williams CB, Spencer RH, Aguilar BA, Ghanshani S, Tempel BL, Gutman GA. A family of three mouse potassium channel genes with intronless coding regions. Science (New York, N.Y.). 247: 973-5. PMID 2305265 DOI: 10.1126/Science.2305265  0.467
1990 Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG. Expression and chromosomal localization of a lymphocyte K+ channel gene. Proceedings of the National Academy of Sciences of the United States of America. 87: 9411-5. PMID 2251283 DOI: 10.1073/Pnas.87.23.9411  0.464
1988 Frank MB, Gutman GA. Two pseudogenes among three rat immunoglobulin lambda chain genes. Molecular Immunology. 25: 953-60. PMID 3146024 DOI: 10.1016/0161-5890(88)90001-6  0.328
1987 Frank MB, Besta RM, Baverstock PR, Gutman GA. The structure and evolution of immunoglobulin kappa chain constant region genes in the genus Rattus. Molecular Immunology. 24: 953-61. PMID 3116413 DOI: 10.1016/0161-5890(87)90006-X  0.34
1987 Gutman GA, Besta RM, Frank MB, Baverstock PR. Duplication of J kappa genes within genus Rattus. Immunogenetics. 26: 14-20. PMID 3111993 DOI: 10.1007/Bf00345449  0.315
1987 Zhou DFH, Guo KZ, Tilles SA, Gutman GA. Expression of two mRNAs for immunoglobulin lambda chains in the rat Molecular Immunology. 24: 1151-1158. PMID 2447492 DOI: 10.1016/0161-5890(87)90161-1  0.319
1984 Frank MB, Besta RM, Baverstock PR, Gutman GA. Kappa-chain constant-region gene sequences in genus Rattus: coding regions are diverging more rapidly than noncoding regions. Molecular Biology and Evolution. 1: 489-501. PMID 6443796 DOI: 10.1093/Oxfordjournals.Molbev.A040328  0.324
1982 Sheppard HW, Gutman GA. Rat kappa-chain J-segment genes: Two recent gene duplications separate rat and mouse Cell. 29: 121-127. PMID 6286136 DOI: 10.1016/0092-8674(82)90096-4  0.361
1981 Sheppard HW, Gutman GA. Complex allotypes of rat κ chains are encoded by structural alleles Nature. 293: 669-671. PMID 6793876 DOI: 10.1038/293669A0  0.345
1978 Warner NL, Harris AW, McKenzie IF, De Luca D, Gutman G. Lymphocyte differentiation as analyzed by the expression of defined cell surface markers. Advances in Experimental Medicine and Biology. 98: 483-95. PMID 717178 DOI: 10.1007/978-1-4615-8858-0_29  0.316
1976 Gutman GA, Loh E, Hood L. Structure and regulation of immunoglobulins: kappa allotypes in the rat have multiple amino-acid differences in the constant region. Proceedings of the National Academy of Sciences of the United States of America. 72: 5046-50. PMID 813219 DOI: 10.1073/Pnas.72.12.5046  0.338
1973 Gutman GA, Weissman IL. Homing properties of thymus-independent follicular lymphocytes. Transplantation. 16: 621-9. PMID 4585386 DOI: 10.1097/00007890-197312000-00014  0.359
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