| Year |
Citation |
Score |
| 2024 |
Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F. Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8. Science Advances. 10: eadj7500. PMID 38306437 DOI: 10.1126/sciadv.adj7500 |
0.518 |
|
| 2023 |
Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, ... ... Xu F, et al. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nature Chemical Biology. PMID 37945893 DOI: 10.1038/s41589-023-01456-6 |
0.398 |
|
| 2023 |
Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, ... ... Xu F, et al. Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature. PMID 37935377 DOI: 10.1038/s41586-023-06775-1 |
0.38 |
|
| 2023 |
Li C, Wu Y, Wang W, Xu L, Zhou Y, Yue Y, Wu T, Yang M, Qiu Y, Huang M, Zhou F, Zhou Y, Hao P, Lin Z, Wang MW, ... ... Xu F, et al. Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7. Journal of Medicinal Chemistry. PMID 37669317 DOI: 10.1021/acs.jmedchem.2c01795 |
0.374 |
|
| 2023 |
Chen Y, Chen B, Wu T, Zhou F, Xu F. Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A. Protein & Cell. 14: 464-468. PMID 37285260 DOI: 10.1093/procel/pwac033 |
0.308 |
|
| 2023 |
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F. The activation mechanism and antibody binding mode for orphan GPR20. Cell Discovery. 9: 23. PMID 36849514 DOI: 10.1038/s41421-023-00520-8 |
0.336 |
|
| 2023 |
Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F. Cryo-EM structures of orphan GPR21 signaling complexes. Nature Communications. 14: 216. PMID 36639690 DOI: 10.1038/s41467-023-35882-w |
0.456 |
|
| 2022 |
Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault É, Longpré JM, Shi S, Lei H, ... ... Xu F, et al. Structural insight into apelin receptor-G protein stoichiometry. Nature Structural & Molecular Biology. 29: 688-697. PMID 35817871 DOI: 10.1038/s41594-022-00797-5 |
0.737 |
|
| 2021 |
Liu Y, Zhou F, Ding K, Xue D, Zhu Z, Li C, Li F, Xu Y, Xu F, Le Z, Zhao S, Tao H. Structure-Activity Relationship Studies of Hydantoin-Cored Ligands for Smoothened Receptor. Chemistryopen. 10: 1028-1032. PMID 34648230 DOI: 10.1002/open.202100216 |
0.367 |
|
| 2021 |
Zhao F, Wu Y, Zhou F, Xue D, Zhao S, Lu W, Liu X, Hu T, Qiu Y, Li R, Gu T, Xu Y, Xu F, Zhong G, Jiang Z, et al. Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement. Journal of Medicinal Chemistry. PMID 34492176 DOI: 10.1021/acs.jmedchem.1c01220 |
0.351 |
|
| 2021 |
Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F. Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G. Cell Research. PMID 34239071 DOI: 10.1038/s41422-021-00525-6 |
0.653 |
|
| 2020 |
Ma M, Guo S, Lin X, Li S, Wu Y, Zeng Y, Hu Y, Zhao S, Xu F, Xie X, Shui W. Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52. Acs Chemical Biology. PMID 33258587 DOI: 10.1021/acschembio.0c00867 |
0.358 |
|
| 2020 |
Huang W, Wu Q, Xu F, Li L, Li J, Que H, Zhang G. Functional characterization of retinoid X receptor with an emphasis on the mediation of organotin poisoning in the Pacific oyster (Crassostrea gigas). Gene. 144780. PMID 32439374 DOI: 10.1016/j.gene.2020.144780 |
0.317 |
|
| 2020 |
Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, ... Xu F, et al. Structural basis of ligand recognition and self-activation of orphan GPR52. Nature. PMID 32076264 DOI: 10.1038/S41586-020-2019-0 |
0.492 |
|
| 2019 |
Zhou F, Ding K, Zhou Y, Liu Y, Liu X, Zhao F, Wu Y, Zhang X, Tan Q, Stevens RC, Xu F, Tan W, Xiao Y, Zhao S, Tao H. Co-Localization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor. Journal of Medicinal Chemistry. PMID 31408335 DOI: 10.1021/Acs.Jmedchem.9B00283 |
0.742 |
|
| 2019 |
Xue D, Ye L, Zheng J, Wu Y, Zhang X, Xu Y, Li T, Stevens RC, Xu F, Zhuang M, Zhao S, Zhao F, Tao H. The structure-based traceless specific fluorescence labeling of the smoothened receptor. Organic & Biomolecular Chemistry. PMID 31180094 DOI: 10.1039/C9Ob00654K |
0.724 |
|
| 2018 |
Zhang X, Dong S, Xu F. Structural and Druggability Landscape of Frizzled G Protein-Coupled Receptors. Trends in Biochemical Sciences. PMID 30309741 DOI: 10.1016/J.Tibs.2018.09.002 |
0.779 |
|
| 2018 |
Yang S, Wu Y, Xu TH, de Waal PW, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, ... ... Xu F, et al. Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature. PMID 30135577 DOI: 10.1038/S41586-018-0447-X |
0.788 |
|
| 2017 |
Ye L, Ding K, Zhao F, Liu X, Wu Y, Liu Y, Xue D, Zhou F, Zhang X, Stevens RC, Xu F, Zhao S, Tao H. A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor. Medchemcomm. 8: 1332-1336. PMID 30108845 DOI: 10.1039/C7Md00104E |
0.771 |
|
| 2017 |
Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, ... ... Xu F, et al. Structural Basis for Apelin Control of the Human Apelin Receptor. Structure (London, England : 1993). PMID 28528775 DOI: 10.1016/J.Str.2017.04.008 |
0.721 |
|
| 2017 |
Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, ... ... Xu F, et al. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nature Communications. 8: 15383. PMID 28513578 DOI: 10.1038/Ncomms15383 |
0.787 |
|
| 2015 |
Zhang X, Stevens RC, Xu F. The importance of ligands for G protein-coupled receptor stability. Trends in Biochemical Sciences. 40: 79-87. PMID 25601764 DOI: 10.1016/J.Tibs.2014.12.005 |
0.794 |
|
| 2012 |
Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC. Structural basis for allosteric regulation of GPCRs by sodium ions. Science (New York, N.Y.). 337: 232-6. PMID 22798613 DOI: 10.1126/Science.1219218 |
0.755 |
|
| 2012 |
Chun E, Thompson AA, Liu W, Roth CB, Griffith MT, Katritch V, Kunken J, Xu F, Cherezov V, Hanson MA, Stevens RC. Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure (London, England : 1993). 20: 967-76. PMID 22681902 DOI: 10.1016/J.Str.2012.04.010 |
0.741 |
|
| 2012 |
Tosh DK, Phan K, Gao ZG, Gakh AA, Xu F, Deflorian F, Abagyan R, Stevens RC, Jacobson KA, Katritch V. Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening. Journal of Medicinal Chemistry. 55: 4297-308. PMID 22486652 DOI: 10.1021/Jm300095S |
0.761 |
|
| 2012 |
Deflorian F, Kumar TS, Phan K, Gao ZG, Xu F, Wu H, Katritch V, Stevens RC, Jacobson KA. Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound Aâ‚‚A adenosine receptor. Journal of Medicinal Chemistry. 55: 538-52. PMID 22104008 DOI: 10.1021/Jm201461Q |
0.795 |
|
| 2011 |
Xu F, Stevens RC. Trapping small caffeine in a large GPCR pocket. Structure (London, England : 1993). 19: 1204-7. PMID 21893281 DOI: 10.1016/J.Str.2011.08.007 |
0.614 |
|
| 2011 |
Xu F, Liu W, Hanson MA, Stevens RC, Cherezov V. Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases. Crystal Growth & Design. 11: 1193-1201. PMID 21660116 DOI: 10.1021/Cg101385E |
0.699 |
|
| 2011 |
Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC. Structure of an agonist-bound human A2A adenosine receptor. Science (New York, N.Y.). 332: 322-7. PMID 21393508 DOI: 10.1126/Science.1202793 |
0.805 |
|
| 2011 |
Cherezov V, Wu B, Chien E, Liu W, Xu F, Stevens RC. Structural biology of G protein-coupled receptors Acta Crystallographica Section a Foundations of Crystallography. 67: C132-C132. DOI: 10.1107/S0108767311096760 |
0.651 |
|
| 2008 |
Guo M, Xu F, Yamada J, Egelhofer T, Gao Y, Hartzog GA, Teng M, Niu L. Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation. Structure (London, England : 1993). 16: 1649-58. PMID 19000817 DOI: 10.1016/J.Str.2008.08.013 |
0.339 |
|
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