| Year |
Citation |
Score |
| 2023 |
Kim SH, Shin S, Baek M, Xiong K, Karottki KJC, Hefzi H, Grav LM, Pedersen LE, Kildegaard HF, Lewis NE, Lee JS, Lee GM. Identification of hyperosmotic stress-responsive genes in Chinese hamster ovary cells via genome-wide virus-free CRISPR/Cas9 screening. Metabolic Engineering. PMID 37709005 DOI: 10.1016/j.ymben.2023.09.006 |
0.618 |
|
| 2023 |
Masson HO, Karottki KJC, Tat J, Hefzi H, Lewis NE. From observational to actionable: rethinking omics in biologics production. Trends in Biotechnology. PMID 37062598 DOI: 10.1016/j.tibtech.2023.03.009 |
0.521 |
|
| 2022 |
Ha TK, Òdena A, Karottki KJC, Kim CL, Hefzi H, Lee GM, Faustrup Kildegaard H, Nielsen LK, Grav LM, Lewis NE. Enhancing CHO cell productivity through a dual selection system using Aspg and Gs in glutamine free medium. Biotechnology and Bioengineering. PMID 36562657 DOI: 10.1002/bit.28318 |
0.543 |
|
| 2021 |
Xiong K, Karottki KJC, Hefzi H, Li S, Grav LM, Li S, Spahn P, Lee JS, Ventina I, Lee GM, Lewis NE, Kildegaard HF, Pedersen LE. Erratum: An optimized genome-wide, virus-free CRISPR screen for mammalian cells. Cell Reports Methods. 1: 100115. PMID 35475003 DOI: 10.1016/j.crmeth.2021.100115 |
0.749 |
|
| 2021 |
Spahn PN, Zhang X, Hu Q, Lu H, Hamaker NK, Hefzi H, Li S, Kuo CC, Huang Y, Lee JC, Davis AJ, Ly P, Lee KH, Lewis NE. Restoration of DNA Repair Mitigates Genome Instability and Increases Productivity of Chinese Hamster Ovary Cells. Biotechnology and Bioengineering. PMID 34953085 DOI: 10.1002/bit.28016 |
0.761 |
|
| 2021 |
Xiong K, Karottki KJC, Hefzi H, Li S, Grav LM, Li S, Spahn P, Lee JS, Ventina I, Lee GM, Lewis NE, Kildegaard HF, Pedersen LE. An optimized genome-wide, virus-free CRISPR screen for mammalian cells. Cell Reports Methods. 1. PMID 34935002 DOI: 10.1016/j.crmeth.2021.100062 |
0.767 |
|
| 2021 |
Shamie I, Duttke SH, Karottki KJC, Han CZ, Hansen AH, Hefzi H, Xiong K, Li S, Roth SJ, Tao J, Lee GM, Glass CK, Kildegaard HF, Benner C, Lewis NE. A Chinese hamster transcription start site atlas that enables targeted editing of CHO cells. Nar Genomics and Bioinformatics. 3: lqab061. PMID 34268494 DOI: 10.1093/nargab/lqab061 |
0.757 |
|
| 2021 |
Karottki KJC, Hefzi H, Li S, Pedersen LE, Spahn PN, Joshi C, Ruckerbauer D, Bort JAH, Thomas A, Lee JS, Borth N, Lee GM, Kildegaard HF, Lewis NE. A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes. Metabolic Engineering. PMID 33813034 DOI: 10.1016/j.ymben.2021.03.017 |
0.75 |
|
| 2020 |
Gutierrez JM, Feizi A, Li S, Kallehauge TB, Hefzi H, Grav LM, Ley D, Baycin Hizal D, Betenbaugh MJ, Voldborg B, Faustrup Kildegaard H, Min Lee G, Palsson BO, Nielsen J, Lewis NE. Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion. Nature Communications. 11: 68. PMID 31896772 DOI: 10.1038/S41467-019-13867-Y |
0.757 |
|
| 2019 |
Julie la Cour Karottki K, Hefzi H, Xiong K, Shamie I, Hansen AH, Li S, Pedersen LE, Li S, Lee JS, Lee GM, Kildegaard HF, Lewis NE. Awakening dormant glycosyltransferases in CHO cells with CRISPRa. Biotechnology and Bioengineering. PMID 31631317 DOI: 10.1002/Bit.27199 |
0.767 |
|
| 2019 |
Ley D, Pereira S, Pedersen LE, Arnsdorf J, Hefzi H, Davy AM, Ha TK, Wulff T, Kildegaard HF, Andersen MR. Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion. Metabolic Engineering. PMID 31526854 DOI: 10.1016/J.Ymben.2019.09.005 |
0.468 |
|
| 2019 |
Pristovsek N, Nallapereddy S, Grav LM, Hefzi H, Lewis NE, Rugbjerg P, Hansen HG, Lee GM, Andersen MR, Kildegaard HF. Systematic Evaluation of Site-Specific Recombinant Gene Expression for Programmable Mammalian Cell Engineering. Acs Synthetic Biology. PMID 30807689 DOI: 10.1021/Acssynbio.8B00453 |
0.586 |
|
| 2018 |
Brunk E, Chang RL, Xia J, Hefzi H, Yurkovich JT, Kim D, Buckmiller E, Wang HH, Cho BK, Yang C, Palsson BO, Church GM, Lewis NE. Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow. Proceedings of the National Academy of Sciences of the United States of America. PMID 30301795 DOI: 10.1073/Pnas.1811971115 |
0.748 |
|
| 2018 |
Abdel-Haleem AM, Hefzi H, Mineta K, Gao X, Gojobori T, Palsson BO, Lewis NE, Jamshidi N. Functional interrogation of Plasmodium genus metabolism identifies species- and stage-specific differences in nutrient essentiality and drug targeting. Plos Computational Biology. 14: e1005895. PMID 29300748 DOI: 10.1371/Journal.Pcbi.1005895 |
0.74 |
|
| 2016 |
Hefzi H, Ang KS, Hanscho M, Bordbar A, Ruckerbauer D, Lakshmanan M, Orellana CA, Baycin-Hizal D, Huang Y, Ley D, Martinez VS, Kyriakopoulos S, Jiménez NE, Zielinski DC, Quek LE, et al. A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism. Cell Systems. 3: 434-443.e8. PMID 27883890 DOI: 10.1016/J.Cels.2016.10.020 |
0.715 |
|
| 2016 |
Swainston N, Smallbone K, Hefzi H, Dobson PD, Brewer J, Hanscho M, Zielinski DC, Ang KS, Gardiner NJ, Gutierrez JM, Kyriakopoulos S, Lakshmanan M, Li S, Liu JK, Martínez VS, et al. Recon 2.2: from reconstruction to model of human metabolism. Metabolomics : Official Journal of the Metabolomic Society. 12: 109. PMID 27358602 DOI: 10.1007/S11306-016-1051-4 |
0.7 |
|
| 2016 |
Golabgir A, Gutierrez JM, Hefzi H, Li S, Palsson BO, Herwig C, Lewis NE. Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow. Biotechnology Advances. PMID 26948029 DOI: 10.1016/J.Biotechadv.2016.02.011 |
0.732 |
|
| 2014 |
Hefzi H, Lewis NE. From random mutagenesis to systems biology in metabolic engineering of mammalian cells Pharmaceutical Bioprocessing. 2: 355-358. DOI: 10.4155/Pbp.14.36 |
0.678 |
|
| 2013 |
Hefzi H, Palsson BO, Lewis NE. Reconstruction of Genome-Scale Metabolic Networks Handbook of Systems Biology. 229-250. DOI: 10.1016/B978-0-12-385944-0.00012-5 |
0.648 |
|
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