| Year |
Citation |
Score |
| 2024 |
Phongbunchoo Y, Braikia FZ, Pessoa-Rodrigues C, Ramamoorthy S, Ramachandran H, Grosschedl A, Ma F, Cauchy P, Akhtar A, Sen R, Mittler G, Grosschedl R. YY1-mediated enhancer-promoter communication in the immunoglobulin μ locus is regulated by MSL/MOF recruitment. Cell Reports. 43: 114456. PMID 38990722 DOI: 10.1016/j.celrep.2024.114456 |
0.314 |
|
| 2024 |
Karayol R, Borroto MC, Haghshenas S, Namasivayam A, Reilly J, Levy MA, Relator R, Kerkhof J, McConkey H, Shvedunova M, Petersen AK, Magnussen K, Zweier C, Vasileiou G, Reis A, ... ... Akhtar A, et al. MSL2 variants lead to a neurodevelopmental syndrome with lack of coordination, epilepsy, specific dysmorphisms, and a distinct episignature. American Journal of Human Genetics. PMID 38815585 DOI: 10.1016/j.ajhg.2024.05.001 |
0.3 |
|
| 2024 |
Zhou Y, Panhale A, Shvedunova M, Balan M, Gomez-Auli A, Holz H, Seyfferth J, Helmstädter M, Kayser S, Zhao Y, Erdogdu NU, Grzadzielewska I, Mittler G, Manke T, Akhtar A. RNA damage compartmentalization by DHX9 stress granules. Cell. 187: 1701-1718.e28. PMID 38503283 DOI: 10.1016/j.cell.2024.02.028 |
0.624 |
|
| 2023 |
Sun Y, Wiese M, Hmadi R, Karayol R, Seyfferth J, Martinez Greene JA, Erdogdu NU, Deboutte W, Arrigoni L, Holz H, Renschler G, Hirsch N, Foertsch A, Basilicata MF, Stehle T, ... ... Akhtar A, et al. MSL2 ensures biallelic gene expression in mammals. Nature. PMID 38030723 DOI: 10.1038/s41586-023-06781-3 |
0.66 |
|
| 2023 |
Tsang TH, Wiese M, Helmstädter M, Stehle T, Seyfferth J, Shvedunova M, Holz H, Walz G, Akhtar A. Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells. Science Advances. 9: eadh5598. PMID 37624894 DOI: 10.1126/sciadv.adh5598 |
0.347 |
|
| 2020 |
Valsecchi CIK, Basilicata MF, Georgiev P, Gaub A, Seyfferth J, Kulkarni T, Panhale A, Semplicio G, Manjunath V, Holz H, Dasmeh P, Akhtar A. RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature. PMID 33208948 DOI: 10.1038/s41586-020-2935-z |
0.405 |
|
| 2020 |
Pessoa Rodrigues C, Herman JS, Herquel B, Valsecchi CIK, Stehle T, Grün D, Akhtar A. Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate. Science Advances. 6: eaaz4815. PMID 32671208 DOI: 10.1126/sciadv.aaz4815 |
0.351 |
|
| 2020 |
Samata M, Alexiadis A, Richard G, Georgiev P, Nuebler J, Kulkarni T, Renschler G, Basilicata MF, Zenk FL, Shvedunova M, Semplicio G, Mirny L, Iovino N, Akhtar A. Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation. Cell. PMID 32502394 DOI: 10.1016/J.Cell.2020.05.026 |
0.342 |
|
| 2020 |
Gaub A, Sheikh BN, Basilicata MF, Vincent M, Nizon M, Colson C, Bird MJ, Bradner JE, Thevenon J, Boutros M, Akhtar A. Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Nature Communications. 11: 2243. PMID 32382029 DOI: 10.1038/s41467-020-16103-0 |
0.436 |
|
| 2020 |
Ilik IA, Aktas T, Maticzka D, Backofen R, Akhtar A. FLASH: ultra-fast protocol to identify RNA-protein interactions in cells. Nucleic Acids Research. 48: e15. PMID 31802123 DOI: 10.1093/nar/gkz1141 |
0.307 |
|
| 2019 |
Bhardwaj V, Semplicio G, Erdogdu NU, Manke T, Akhtar A. MAPCap allows high-resolution detection and differential expression analysis of transcription start sites. Nature Communications. 10: 3219. PMID 31363093 DOI: 10.1038/s41467-019-11115-x |
0.653 |
|
| 2019 |
Sheikh BN, Guhathakurta S, Akhtar A. The non-specific lethal (NSL) complex at the crossroads of transcriptional control and cellular homeostasis. Embo Reports. 20: e47630. PMID 31267707 DOI: 10.15252/embr.201847630 |
0.372 |
|
| 2019 |
Panhale A, Richter FM, Ramírez F, Shvedunova M, Manke T, Mittler G, Akhtar A. CAPRI enables comparison of evolutionarily conserved RNA interacting regions. Nature Communications. 10: 2682. PMID 31213602 DOI: 10.1038/s41467-019-10585-3 |
0.648 |
|
| 2019 |
Lam KC, Chung HR, Semplicio G, Iyer SS, Gaub A, Bhardwaj V, Holz H, Georgiev P, Akhtar A. The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise. Genes & Development. PMID 30819819 DOI: 10.1101/gad.321489.118 |
0.376 |
|
| 2018 |
Valsecchi CIK, Basilicata MF, Semplicio G, Georgiev P, Gutierrez NM, Akhtar A. Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells. Nature Communications. 9: 3626. PMID 30194291 DOI: 10.1038/s41467-018-05642-2 |
0.359 |
|
| 2018 |
Samata M, Akhtar A. Dosage Compensation of the X Chromosome: A Complex Epigenetic Assignment Involving Chromatin Regulators and Long Noncoding RNAs. Annual Review of Biochemistry. 87: 323-350. PMID 29668306 DOI: 10.1146/annurev-biochem-062917-011816 |
0.39 |
|
| 2018 |
Ramírez F, Bhardwaj V, Arrigoni L, Lam KC, Grüning BA, Villaveces J, Habermann B, Akhtar A, Manke T. High-resolution TADs reveal DNA sequences underlying genome organization in flies. Nature Communications. 9: 189. PMID 29335486 DOI: 10.1038/s41467-017-02525-w |
0.589 |
|
| 2017 |
Ilik IA, Maticzka D, Georgiev P, Gutierrez NM, Backofen R, Akhtar A. A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila. Genes & Development. PMID 29066499 DOI: 10.1101/gad.304600.117 |
0.38 |
|
| 2017 |
Aktaş T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, Manke T, Backofen R, Akhtar A. DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature. PMID 28355180 DOI: 10.1038/nature21715 |
0.656 |
|
| 2016 |
Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, Dündar F, Dasmeh P, Mittler G, Cadete FT, Ramírez F, Conrad T, Wei W, Raja S, Manke T, ... ... Akhtar A, et al. Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation. Nature Structural & Molecular Biology. PMID 27183194 DOI: 10.1038/Nsmb.3233 |
0.729 |
|
| 2016 |
Quinn JJ, Zhang QC, Georgiev P, Ilik IA, Akhtar A, Chang HY. Rapid evolutionary turnover underlies conserved lncRNA-genome interactions. Genes & Development. 30: 191-207. PMID 26773003 DOI: 10.1101/Gad.272187.115 |
0.324 |
|
| 2015 |
Ramírez F, Lingg T, Toscano S, Lam KC, Georgiev P, Chung HR, Lajoie BR, de Wit E, Zhan Y, de Laat W, Dekker J, Manke T, Akhtar A. High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila. Molecular Cell. 60: 146-62. PMID 26431028 DOI: 10.1016/J.Molcel.2015.08.024 |
0.658 |
|
| 2015 |
Meunier S, Shvedunova M, Van Nguyen N, Avila L, Vernos I, Akhtar A. An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Nature Communications. 6: 7889. PMID 26243146 DOI: 10.1038/ncomms8889 |
0.351 |
|
| 2015 |
Keller CI, Akhtar A. The MSL complex: juggling RNA-protein interactions for dosage compensation and beyond. Current Opinion in Genetics & Development. 31: 1-11. PMID 25900149 DOI: 10.1016/j.gde.2015.03.007 |
0.389 |
|
| 2014 |
Quinn JJ, Ilik IA, Qu K, Georgiev P, Chu C, Akhtar A, Chang HY. Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification. Nature Biotechnology. 32: 933-40. PMID 24997788 DOI: 10.1038/Nbt.2943 |
0.332 |
|
| 2014 |
Chelmicki T, Dündar F, Turley MJ, Khanam T, Aktas T, Ramírez F, Gendrel AV, Wright PR, Videm P, Backofen R, Heard E, Manke T, Akhtar A. MOF-associated complexes ensure stem cell identity and Xist repression. Elife. 3: e02024. PMID 24842875 DOI: 10.7554/eLife.02024 |
0.688 |
|
| 2014 |
Dias J, Van Nguyen N, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J, Akhtar A. Structural analysis of the KANSL1/WDR5/ KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex Genes and Development. 28: 929-942. PMID 24788516 DOI: 10.1101/Gad.240200.114 |
0.359 |
|
| 2013 |
Ilik IA, Quinn JJ, Georgiev P, Tavares-Cadete F, Maticzka D, Toscano S, Wan Y, Spitale RC, Luscombe N, Backofen R, Chang HY, Akhtar A. Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila. Molecular Cell. 51: 156-73. PMID 23870142 DOI: 10.1016/J.Molcel.2013.07.001 |
0.393 |
|
| 2012 |
Hallacli E, Lipp M, Georgiev P, Spielman C, Cusack S, Akhtar A, Kadlec J. Msl1-Mediated Dimerization of the Dosage Compensation Complex Is Essential for Male X-Chromosome Regulation in Drosophila Molecular Cell. 48: 587-600. PMID 23084835 DOI: 10.1016/J.Molcel.2012.09.014 |
0.319 |
|
| 2012 |
Conrad T, Cavalli FM, Vaquerizas JM, Luscombe NM, Akhtar A. Drosophila dosage compensation involves enhanced Pol II recruitment to male X-linked promoters. Science (New York, N.Y.). 337: 742-6. PMID 22821985 DOI: 10.1126/science.1221428 |
0.377 |
|
| 2012 |
Lam KC, Mühlpfordt F, Vaquerizas JM, Raja SJ, Holz H, Luscombe NM, Manke T, Akhtar A. The NSL complex regulates housekeeping genes in Drosophila. Plos Genetics. 8: e1002736. PMID 22723752 DOI: 10.1371/journal.pgen.1002736 |
0.692 |
|
| 2012 |
Conrad T, Cavalli FM, Holz H, Hallacli E, Kind J, Ilik I, Vaquerizas JM, Luscombe NM, Akhtar A. The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex. Developmental Cell. 22: 610-24. PMID 22421046 DOI: 10.1016/j.devcel.2011.12.016 |
0.36 |
|
| 2011 |
Conrad T, Akhtar A. Dosage compensation in Drosophila melanogaster: epigenetic fine-tuning of chromosome-wide transcription. Nature Reviews. Genetics. 13: 123-34. PMID 22251873 DOI: 10.1038/nrg3124 |
0.359 |
|
| 2011 |
Georgiev P, Chlamydas S, Akhtar A. Drosophila dosage compensation: males are from Mars, females are from Venus. Fly. 5: 147-54. PMID 21339706 DOI: 10.4161/fly.5.2.14934 |
0.351 |
|
| 2011 |
Arib G, Akhtar A. Multiple facets of nuclear periphery in gene expression control. Current Opinion in Cell Biology. 23: 346-53. PMID 21242077 DOI: 10.1016/j.ceb.2010.12.005 |
0.337 |
|
| 2011 |
Kadlec J, Hallacli E, Lipp M, Holz H, Sanchez-Weatherby J, Cusack S, Akhtar A. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. Nature Structural & Molecular Biology. 18: 142-9. PMID 21217699 DOI: 10.1038/Nsmb.1960 |
0.316 |
|
| 2010 |
Andersen DS, Raja SJ, Colombani J, Shaw RL, Langton PF, Akhtar A, Tapon N. Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription. Molecular and Cellular Biology. 30: 4744-55. PMID 20679484 DOI: 10.1128/Mcb.01586-09 |
0.451 |
|
| 2010 |
Raja SJ, Charapitsa I, Conrad T, Vaquerizas JM, Gebhardt P, Holz H, Kadlec J, Fraterman S, Luscombe NM, Akhtar A. The nonspecific lethal complex is a transcriptional regulator in Drosophila. Molecular Cell. 38: 827-41. PMID 20620954 DOI: 10.1016/j.molcel.2010.05.021 |
0.387 |
|
| 2010 |
Laverty C, Lucci J, Akhtar A. The MSL complex: X chromosome and beyond. Current Opinion in Genetics & Development. 20: 171-8. PMID 20167472 DOI: 10.1016/j.gde.2010.01.007 |
0.368 |
|
| 2009 |
Hallacli E, Akhtar A. X chromosomal regulation in flies: when less is more. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 17: 603-19. PMID 19802702 DOI: 10.1007/s10577-009-9054-x |
0.31 |
|
| 2009 |
Zhou Y, Schmitz KM, Mayer C, Yuan X, Akhtar A, Grummt I. Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing. Nature Cell Biology. 11: 1010-6. PMID 19578370 DOI: 10.1038/ncb1914 |
0.398 |
|
| 2009 |
Ilik I, Akhtar A. roX RNAs: non-coding regulators of the male X chromosome in flies. Rna Biology. 6: 113-21. PMID 19229132 DOI: 10.4161/rna.6.2.8060 |
0.39 |
|
| 2008 |
Kind J, Vaquerizas JM, Gebhardt P, Gentzel M, Luscombe NM, Bertone P, Akhtar A. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Cell. 133: 813-28. PMID 18510926 DOI: 10.1016/J.Cell.2008.04.036 |
0.358 |
|
| 2008 |
Bell O, Conrad T, Kind J, Wirbelauer C, Akhtar A, Schübeler D. Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster. Molecular and Cellular Biology. 28: 3401-9. PMID 18347056 DOI: 10.1128/MCB.00006-08 |
0.378 |
|
| 2008 |
Pfister S, Rea S, Taipale M, Mendrzyk F, Straub B, Ittrich C, Thuerigen O, Sinn HP, Akhtar A, Lichter P. The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. International Journal of Cancer. 122: 1207-13. PMID 18058815 DOI: 10.1002/ijc.23283 |
0.597 |
|
| 2007 |
Kind J, Akhtar A. Cotranscriptional recruitment of the dosage compensation complex to X-linked target genes. Genes & Development. 21: 2030-40. PMID 17699750 DOI: 10.1101/gad.430807 |
0.364 |
|
| 2007 |
Akhtar A, Gasser SM. The nuclear envelope and transcriptional control. Nature Reviews. Genetics. 8: 507-17. PMID 17549064 DOI: 10.1038/nrg2122 |
0.388 |
|
| 2006 |
Mendjan S, Akhtar A. The right dose for every sex. Chromosoma. 116: 95-106. PMID 17124606 DOI: 10.1007/s00412-006-0089-x |
0.453 |
|
| 2006 |
Buscaino A, Legube G, Akhtar A. X-chromosome targeting and dosage compensation are mediated by distinct domains in MSL-3. Embo Reports. 7: 531-8. PMID 16547465 DOI: 10.1038/sj.embor.7400658 |
0.32 |
|
| 2006 |
Legube G, McWeeney SK, Lercher MJ, Akhtar A. X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila. Genes & Development. 20: 871-83. PMID 16547175 DOI: 10.1101/Gad.377506 |
0.326 |
|
| 2006 |
Mendjan S, Taipale M, Kind J, Holz H, Gebhardt P, Schelder M, Vermeulen M, Buscaino A, Duncan K, Mueller J, Wilm M, Stunnenberg HG, Saumweber H, Akhtar A. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila Molecular Cell. 21: 811-823. PMID 16543150 DOI: 10.1016/j.molcel.2006.02.007 |
0.718 |
|
| 2006 |
Niggeweg R, Köcher T, Gentzel M, Buscaino A, Taipale M, Akhtar A, Wilm M. A general precursor ion-like scanning mode on quadrupole-TOF instruments compatible with chromatographic separation. Proteomics. 6: 41-53. PMID 16302280 DOI: 10.1002/pmic.200501332 |
0.571 |
|
| 2005 |
Taipale M, Rea S, Richter K, Vilar A, Lichter P, Imhof A, Akhtar A. hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Molecular and Cellular Biology. 25: 6798-810. PMID 16024812 DOI: 10.1128/MCB.25.15.6798-6810.2005 |
0.66 |
|
| 2005 |
Taipale M, Akhtar A. Chromatin mechanisms in Drosophila dosage compensation. Progress in Molecular and Subcellular Biology. 38: 123-49. PMID 15881893 DOI: 10.1007/3-540-27310-7_5 |
0.701 |
|
| 2004 |
Morales V, Straub T, Neumann MF, Mengus G, Akhtar A, Becker PB. Functional integration of the histone acetyltransferase MOF into the dosage compensation complex. The Embo Journal. 23: 2258-68. PMID 15141166 DOI: 10.1038/sj.emboj.7600235 |
0.412 |
|
| 2003 |
Buscaino A, Köcher T, Kind JH, Holz H, Taipale M, Wagner K, Wilm M, Akhtar A. MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complex. Molecular Cell. 11: 1265-77. PMID 12769850 DOI: 10.1016/s1097-2765(03)00140-0 |
0.705 |
|
| 2003 |
Akhtar A. Dosage compensation: an intertwined world of RNA and chromatin remodelling. Current Opinion in Genetics & Development. 13: 161-9. PMID 12672493 DOI: 10.1016/s0959-437x(03)00016-9 |
0.382 |
|
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