| Year |
Citation |
Score |
| 2022 |
Thomas SE, McCarthy WJ, El Bakali J, Brown KP, Kim SY, Blaszczyk M, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Structural Characterization of Phosphopantetheine Adenylyl Transferase Ligand Interactions: Implications for Fragment-Based Drug Design. Frontiers in Molecular Biosciences. 9: 880432. PMID 35712348 DOI: 10.3389/fmolb.2022.880432 |
0.619 |
|
| 2022 |
Charoensutthivarakul S, Thomas SE, Curran A, Brown KP, Belardinelli JM, Whitehouse AJ, Acebrón-García-de-Eulate M, Sangan J, Gramani SG, Jackson M, Mendes V, Floto RA, Blundell TL, Coyne AG, Abell C. Development of Inhibitors of SAICAR Synthetase (PurC) from Using a Fragment-Based Approach. Acs Infectious Diseases. PMID 35037462 DOI: 10.1021/acsinfecdis.1c00432 |
0.54 |
|
| 2022 |
Liang S, Thomas SE, Chaplin AK, Hardwick SW, Chirgadze DY, Blundell TL. Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature. PMID 34987222 DOI: 10.1038/s41586-021-04274-9 |
0.745 |
|
| 2021 |
Beaudoin CA, Jamasb AR, Alsulami AF, Copoiu L, van Tonder AJ, Hala S, Bannerman BP, Thomas SE, Vedithi SC, Torres PHM, Blundell TL. Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses. Computational and Structural Biotechnology Journal. PMID 34234921 DOI: 10.1016/j.csbj.2021.06.041 |
0.69 |
|
| 2021 |
Gupta P, Thomas SE, Zaidan SA, Pasillas MA, Cory-Wright J, Sebastián-Pérez V, Burgess A, Cattermole E, Meghir C, Abell C, Coyne AG, Jacobs WR, Blundell TL, Tiwari S, Mendes V. A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of . Computational and Structural Biotechnology Journal. 19: 3491-3506. PMID 34194673 DOI: 10.1016/j.csbj.2021.06.006 |
0.456 |
|
| 2021 |
Alsulami AF, Thomas SE, Jamasb AR, Beaudoin CA, Moghul I, Bannerman B, Copoiu L, Vedithi SC, Torres P, Blundell TL. SARS-CoV-2 3D database: understanding the coronavirus proteome and evaluating possible drug targets. Briefings in Bioinformatics. PMID 33416848 DOI: 10.1093/bib/bbaa404 |
0.665 |
|
| 2020 |
Thomas SE, Whitehouse AJ, Brown K, Burbaud S, Belardinelli JM, Sangen J, Lahiri R, Libardo MDJ, Gupta P, Malhotra S, Boshoff HIM, Jackson M, Abell C, Coyne AG, Blundell TL, et al. Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Research. PMID 32602532 DOI: 10.1093/Nar/Gkaa539 |
0.759 |
|
| 2019 |
Whitehouse A, Thomas SE, Brown KP, Fanourakis A, Chan D, Libardo MDJ, Mendes V, Boshoff HIM, Floto RA, Abell C, Blundell TL, Coyne AG. Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches. Journal of Medicinal Chemistry. PMID 31282680 DOI: 10.1021/Acs.Jmedchem.9B00809 |
0.484 |
|
| 2019 |
Thomas SE, Collins P, James RH, Mendes V, Charoensutthivarakul S, Radoux C, Abell C, Coyne AG, Floto RA, von Delft F, Blundell TL. Structure-guided fragment-based drug discovery at the synchrotron: screening binding sites and correlations with hotspot mapping. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 377: 20180422. PMID 31030650 DOI: 10.1098/Rsta.2018.0422 |
0.558 |
|
| 2019 |
Waman VP, Vedithi SC, Thomas SE, Bannerman BP, Munir A, Skwark MJ, Malhotra S, Blundell TL. Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery. Emerging Microbes & Infections. 8: 109-118. PMID 30866765 DOI: 10.1080/22221751.2018.1561158 |
0.663 |
|
| 2018 |
Tiwari S, van Tonder AJ, Vilchèze C, Mendes V, Thomas SE, Malek A, Chen B, Chen M, Kim J, Blundell TL, Parkhill J, Weinrick B, Berney M, Jacobs WR. Arginine-deprivation-induced oxidative damage sterilizes . Proceedings of the National Academy of Sciences of the United States of America. PMID 30143580 DOI: 10.1073/Pnas.1808874115 |
0.417 |
|
| 2017 |
Thomas SE, Mendes V, Kim SY, Malhotra S, Ochoa-Montaño B, Blaszczyk M, Blundell TL. Structural biology and the design of new therapeutics: from HIV and cancer to mycobacterial infections. Journal of Molecular Biology. PMID 28648615 DOI: 10.1016/j.jmb.2017.06.014 |
0.775 |
|
| 2017 |
Chan DS, Mendes V, Thomas SE, McConnell BN, Matak-Vinković D, Coyne AG, Blundell TL, Abell C. Fragment screening against the EthR-DNA interaction by native mass spectrometry. Angewandte Chemie (International Ed. in English). PMID 28513917 DOI: 10.1002/Anie.201702888 |
0.439 |
|
| 2017 |
Pandurangan AP, Ascher DB, Thomas SE, Blundell TL. Genomes, structural biology and drug discovery: combating the impacts of mutations in genetic disease and antibiotic resistance. Biochemical Society Transactions. 45: 303-311. PMID 28408471 DOI: 10.1042/BST20160422 |
0.785 |
|
| 2017 |
Shiu-Hin Chan D, Seetoh WG, McConnell BN, Matak-Vinković D, Thomas SE, Mendes V, Blaszczyk M, Coyne AG, Blundell TL, Abell C. Structural insights into the EthR-DNA interaction using native mass spectrometry. Chemical Communications (Cambridge, England). PMID 28287239 DOI: 10.1039/C7Cc00804J |
0.428 |
|
| 2016 |
Malhotra S, Thomas SE, Ochoa Montano B, Blundell TL. Structure-guided, target-based drug discovery - exploiting genome information from HIV to mycobacterial infections. Postepy Biochemii. 62: 262-272. PMID 28132480 |
0.786 |
|
| Show low-probability matches. |