| Year |
Citation |
Score |
| 2023 |
Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, ... ... Clemons PA, et al. Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nature Communications. 14: 7589. PMID 37989745 DOI: 10.1038/s41467-023-43518-2 |
0.733 |
|
| 2023 |
Mason JW, Chow YT, Hudson L, Tutter A, Michaud G, Westphal MV, Shu W, Ma X, Tan ZY, Coley CW, Clemons PA, Bonazzi S, Berst F, Briner K, Liu S, et al. DNA-encoded library-enabled discovery of proximity-inducing small molecules. Nature Chemical Biology. PMID 37919549 DOI: 10.1038/s41589-023-01458-4 |
0.511 |
|
| 2023 |
Hudson L, Mason JW, Westphal MV, Richter MJR, Thielman JR, Hua BK, Gerry CJ, Xia G, Osswald HL, Knapp JM, Tan ZY, Kokkonda P, Tresco BIC, Liu S, Reidenbach AG, ... ... Clemons PA, et al. Diversity-oriented synthesis encoded by deoxyoligonucleotides. Nature Communications. 14: 4930. PMID 37582753 DOI: 10.1038/s41467-023-40575-5 |
0.784 |
|
| 2023 |
Athanasiadis P, Ravikumar B, Elliott RJR, Dawson JC, Carragher NO, Clemons PA, Johanssen T, Ebner D, Aittokallio T. Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells. Iscience. 26: 107209. PMID 37485377 DOI: 10.1016/j.isci.2023.107209 |
0.362 |
|
| 2023 |
Moshkov N, Becker T, Yang K, Horvath P, Dancik V, Wagner BK, Clemons PA, Singh S, Carpenter AE, Caicedo JC. Predicting compound activity from phenotypic profiles and chemical structures. Nature Communications. 14: 1967. PMID 37031208 DOI: 10.1038/s41467-023-37570-1 |
0.603 |
|
| 2023 |
Sharifnia T, Wawer MJ, Goodale A, Lee Y, Kazachkova M, Dempster JM, Muller S, Levy J, Freed DM, Sommer J, Kalfon J, Vazquez F, Hahn WC, Root DE, Clemons PA, et al. Mapping the landscape of genetic dependencies in chordoma. Nature Communications. 14: 1933. PMID 37024492 DOI: 10.1038/s41467-023-37593-8 |
0.488 |
|
| 2023 |
Dahlin JL, Hua BK, Zucconi BE, Nelson SD, Singh S, Carpenter AE, Shrimp JH, Lima-Fernandes E, Wawer MJ, Chung LPW, Agrawal A, O'Reilly M, Barsyte-Lovejoy D, Szewczyk M, Li F, ... ... Clemons PA, et al. Reference compounds for characterizing cellular injury in high-content cellular morphology assays. Nature Communications. 14: 1364. PMID 36914634 DOI: 10.1038/s41467-023-36829-x |
0.683 |
|
| 2022 |
Lim D, Zhou Q, Cox KJ, Law BK, Lee M, Kokkonda P, Sreekanth V, Pergu R, Chaudhary SK, Gangopadhyay SA, Maji B, Lai S, Amako Y, Thompson DB, Subramanian HKK, ... ... Clemons PA, et al. A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules. Nature Cell Biology. PMID 36396978 DOI: 10.1038/s41556-022-01005-8 |
0.635 |
|
| 2022 |
Small JC, Joblin-Mills A, Carbone K, Kost-Alimova M, Ayukawa K, Khodier C, Dancik V, Clemons PA, Munkacsi AB, Wagner BK. Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity. Acs Chemical Biology. PMID 35439415 DOI: 10.1021/acschembio.2c00052 |
0.596 |
|
| 2021 |
Clemons PA, Bittker JA, Wagner FF, Hands A, Dančík V, Schreiber SL, Choudhary A, Wagner BK. The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes. Slas Discovery : Advancing Life Sciences R & D. 24725552211019410. PMID 34130532 DOI: 10.1177/24725552211019410 |
0.767 |
|
| 2021 |
Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, et al. An expanded universe of cancer targets. Cell. 184: 1142-1155. PMID 33667368 DOI: 10.1016/j.cell.2021.02.020 |
0.664 |
|
| 2021 |
Sheppard HE, Dall'Agnese A, Park WD, Shamim MH, Dubrulle J, Johnson HL, Stossi F, Cogswell P, Sommer J, Levy J, Sharifnia T, Wawer MJ, Nabet B, Gray NS, Clemons PA, et al. Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity. Cell Reports. Medicine. 2: 100188. PMID 33521702 DOI: 10.1016/j.xcrm.2020.100188 |
0.388 |
|
| 2020 |
Zou Y, Henry WS, Ricq EL, Graham ET, Phadnis VV, Maretich P, Paradkar S, Boehnke N, Deik AA, Reinhardt F, Eaton JK, Ferguson B, Wang W, Fairman J, Keys HR, ... ... Clemons PA, et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature. PMID 32939090 DOI: 10.1038/S41586-020-2732-8 |
0.636 |
|
| 2020 |
Eaton JK, Furst L, Ruberto RA, Moosmayer D, Hilpmann A, Ryan MJ, Zimmermann K, Cai LL, Niehues M, Badock V, Kramm A, Chen S, Hillig RC, Clemons PA, Gradl S, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nature Chemical Biology. PMID 32231343 DOI: 10.1038/S41589-020-0501-5 |
0.56 |
|
| 2019 |
Oberlick EM, Rees MG, Seashore-Ludlow B, Vazquez F, Nelson GM, Dharia NV, Weir BA, Tsherniak A, Ghandi M, Krill-Burger JM, Meyers RM, Wang X, Montgomery P, Root DE, Bieber JM, ... ... Clemons PA, et al. Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors. Cell Reports. 28: 2331-2344.e8. PMID 31461650 DOI: 10.1016/J.Celrep.2019.07.021 |
0.755 |
|
| 2019 |
Gerry CJ, Wawer MJ, Clemons PA, Schreiber SL. DNA barcoding a complete matrix of stereoisomeric small molecules. Journal of the American Chemical Society. PMID 31184885 DOI: 10.1021/Jacs.9B01203 |
0.524 |
|
| 2019 |
Maji B, Gangopadhyay SA, Lee M, Shi M, Wu P, Heler R, Mok B, Lim D, Siriwardena SU, Paul B, Dančík V, Vetere A, Mesleh MF, Marraffini LA, Liu DR, ... Clemons PA, et al. A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9. Cell. 177: 1067-1079.e19. PMID 31051099 DOI: 10.1016/J.Cell.2019.04.009 |
0.684 |
|
| 2019 |
Bessen JL, Afeyan LK, Dančík V, Koblan LW, Thompson DB, Leichner C, Clemons PA, Liu DR. High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nature Communications. 10: 1937. PMID 31028261 DOI: 10.1038/S41467-019-09987-0 |
0.322 |
|
| 2019 |
Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, ... ... Clemons PA, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nature Communications. 10: 1617. PMID 30962421 DOI: 10.1038/S41467-019-09277-9 |
0.758 |
|
| 2019 |
Struntz NB, Chen A, Deutzmann A, Wilson RM, Stefan E, Evans HL, Ramirez MA, Liang T, Caballero F, Wildschut MHE, Neel DV, Freeman DB, Pop MS, McConkey M, Muller S, ... ... Clemons PA, et al. Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription. Cell Chemical Biology. PMID 30880155 DOI: 10.1016/J.Chembiol.2019.02.009 |
0.695 |
|
| 2019 |
Hong AL, Tseng YY, Wala JA, Kim WJ, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, ... ... Clemons PA, et al. Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition. Elife. 8. PMID 30860482 DOI: 10.7554/Elife.44161 |
0.521 |
|
| 2019 |
Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, ... ... Clemons PA, et al. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nature Medicine. PMID 30664779 DOI: 10.1038/S41591-018-0312-3 |
0.668 |
|
| 2019 |
Rees MG, Seashore-Ludlow B, Clemons PA. Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines. Methods in Molecular Biology (Clifton, N.J.). 1888: 233-254. PMID 30519951 DOI: 10.1007/978-1-4939-8891-4_14 |
0.458 |
|
| 2019 |
Hong AL, Tseng Y, Wala JA, Kim W, Kynnap BD, Doshi MB, Kugener G, Sandoval GJ, Howard TP, Li J, Yang X, Tillgren M, Ghandi M, Sayeed A, Deasy R, ... ... Clemons PA, et al. Author response: Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition Elife. DOI: 10.7554/Elife.44161.051 |
0.398 |
|
| 2018 |
Si Y, Xu D, Bum-Erdene K, Ghozayel M, Yang B, Clemons PA, Meroueh S. Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries. Chemmedchem. PMID 30548204 DOI: 10.1002/Cmdc.201800537 |
0.451 |
|
| 2018 |
Weinstein ZB, Kuru N, Kiriakov S, Palmer AC, Khalil AS, Clemons PA, Zaman MH, Roth FP, Cokol M. Modeling the impact of drug interactions on therapeutic selectivity. Nature Communications. 9: 3452. PMID 30150706 DOI: 10.1038/S41467-018-05954-3 |
0.37 |
|
| 2018 |
Melillo B, Zoller J, Hua BK, Verho O, Borghs J, Nelson SD, Maetani M, Wawer MJ, Clemons PA, Schreiber SL. Synergistic effects of stereochemistry and appendages on the performance diversity of a collection of synthetic compounds. Journal of the American Chemical Society. PMID 30133283 DOI: 10.1021/Jacs.8B07319 |
0.818 |
|
| 2018 |
Alvarez MJ, Subramaniam PS, Tang LH, Grunn A, Aburi M, Rieckhof G, Komissarova EV, Hagan EA, Bodei L, Clemons PA, Dela Cruz FS, Dhall D, Diolaiti D, Fraker DA, Ghavami A, et al. A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors. Nature Genetics. PMID 29915428 DOI: 10.1038/S41588-018-0138-4 |
0.521 |
|
| 2018 |
Basu A, Mitra R, Liu H, Schreiber SL, Clemons PA. RWEN: Response-Weighted Elastic Net For Prediction of Chemosensitivity of Cancer Cell Lines. Bioinformatics (Oxford, England). PMID 29688307 DOI: 10.1093/Bioinformatics/Bty199 |
0.554 |
|
| 2018 |
Ferrer-Luna R, Ramkissoon SH, Ramkissoon LA, Pellton K, Schumacher SE, Lamothe R, Cheah JH, Haidar S, Kang YJ, Knoff DS, Maire CL, Olausson KH, Song W, Idbaih A, Rinne ML, ... ... Clemons PA, et al. Abstract B077: Comprehensive molecular characterization and high-throughput chemical screening identifies genetic dependencies and molecular vulnerabilities in glioblastoma cell line models Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-B077 |
0.596 |
|
| 2017 |
Aksoy BA, Dancík V, Smith K, Mazerik JN, Ji Z, Gross B, Nikolova O, Jaber N, Califano A, Schreiber SL, Gerhard DS, Hermida LC, Jagu S, Sander C, Floratos A, ... Clemons PA, et al. CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network. Database : the Journal of Biological Databases and Curation. 2017. PMID 29220450 DOI: 10.1093/Database/Bax054 |
0.488 |
|
| 2017 |
Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, Lahr DL, Hirschman JE, Liu Z, Donahue M, Julian B, ... ... Clemons PA, et al. A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. Cell. 171: 1437-1452.e17. PMID 29195078 DOI: 10.1016/J.Cell.2017.10.049 |
0.751 |
|
| 2017 |
Caicedo JC, Cooper S, Heigwer F, Warchal S, Qiu P, Molnar C, Vasilevich AS, Barry JD, Bansal HS, Kraus O, Wawer M, Paavolainen L, Herrmann MD, Rohban M, Hung J, ... ... Clemons PA, et al. Data-analysis strategies for image-based cell profiling. Nature Methods. 14: 849-863. PMID 28858338 DOI: 10.1038/Nmeth.4397 |
0.315 |
|
| 2017 |
Kim JW, Abudayyeh OO, Yeerna H, Yeang CH, Stewart M, Jenkins RW, Kitajima S, Konieczkowski DJ, Medetgul-Ernar K, Cavazos T, Mah C, Ting S, Van Allen EM, Cohen O, Mcdermott J, ... ... Clemons P, et al. Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States. Cell Systems. 5: 105-118.e9. PMID 28837809 DOI: 10.1016/J.Cels.2017.08.002 |
0.36 |
|
| 2017 |
Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, ... ... Clemons PA, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. PMID 28678785 DOI: 10.1038/Nature23007 |
0.784 |
|
| 2017 |
Bray MA, Gustafsdottir SM, Ljosa V, Singh S, Sokolnicki KL, Bittker JA, Bodycombe NE, Dancík V, Hasaka TP, Hon CS, Kemp MM, Li K, Walpita D, Wawer MJ, Golub TR, ... ... Clemons PA, et al. A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay. Gigascience. PMID 28327978 DOI: 10.1093/Gigascience/Giw014 |
0.706 |
|
| 2017 |
Hong AL, Tseng Y, Kynnap BD, Doshi MB, Sandoval G, Oh C, Sayeed A, Shubhroz G, Church AJ, Keskula P, Peng A, Clemons PA, Tsherniak A, Vazquez F, Rodriguez-Galindo C, et al. Abstract B17: Identification of Druggable Targets through Functional Multi-Omics in Renal Medullary Carcinoma Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-B17 |
0.548 |
|
| 2017 |
Tseng Y(, Hong A, Gill S, Keskula P, Raghavan S, Cheah J, Tsherniak A, Vazquez F, Alkhairy S, Peng A, Sayeed A, Deasy R, Ronning P, Kantoff P, Garraway L, ... ... Clemons P, et al. Abstract A02: Expanding tumor chemical-genetic interaction map using next-generation cancer models Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A02 |
0.691 |
|
| 2017 |
Ferrer-Luna R, Ramkissoon SH, Olausson KH, Ramkissoon LA, Schumacher S, Lamothe R, Cheah JH, Pellton K, Haidar S, Kang YJ, Paolella BR, Maire C, Song W, Meng A, Idbaih A, ... ... Clemons PA, et al. Abstract 4974: Pharmacogenomic interactions in glioblastoma cell line models Cancer Research. 77: 4974-4974. DOI: 10.1158/1538-7445.Am2017-4974 |
0.748 |
|
| 2017 |
Tseng Y, Hong A, Keskula P, Gill S, Cheah J, Kryukov G, Tsherniak A, Vazquez F, Cowley G, Alkhairy S, Oh C, Peng A, Deasy R, Sayeed A, Ronning P, ... ... Clemons P, et al. Abstract 1953: Accelerating prediction of pediatric and rare cancer vulnerabilities using next-generation cancer models Cancer Research. 77: 1953-1953. DOI: 10.1158/1538-7445.Am2017-1953 |
0.626 |
|
| 2016 |
Speyer G, Mahendra D, Tran HJ, Kiefer J, Schreiber SL, Clemons PA, Dhruv H, Berens M, Kim S. DIFFERENTIAL PATHWAY DEPENDENCY DISCOVERY ASSOCIATED WITH DRUG RESPONSE ACROSS CANCER CELL LINES. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 497-508. PMID 27897001 |
0.491 |
|
| 2016 |
Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, ... ... Clemons PA, et al. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. PMID 27641501 DOI: 10.1016/J.Cell.2016.08.057 |
0.579 |
|
| 2016 |
Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, ... ... Clemons PA, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/Nature19804 |
0.796 |
|
| 2016 |
Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, et al. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR. PMID 27401613 DOI: 10.1158/1541-7786.Mcr-16-0090 |
0.802 |
|
| 2016 |
Gerry CJ, Hua BK, Wawer MJ, Knowles JP, Nelson SD, Verho O, Dandapani S, Wagner BK, Clemons PA, Booker-Milburn KI, Boskovic ZV, Schreiber SL. Real-Time Biological Annotation of Synthetic Compounds. Journal of the American Chemical Society. PMID 27398798 DOI: 10.1021/Jacs.6B04614 |
0.81 |
|
| 2016 |
Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, ... ... Clemons PA, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nature Communications. 7: 11987. PMID 27329820 DOI: 10.1038/Ncomms11987 |
0.8 |
|
| 2016 |
Yard BD, Adams DJ, Chie EK, Tamayo P, Battaglia JS, Gopal P, Rogacki K, Pearson BE, Phillips J, Raymond DP, Pennell NA, Almeida F, Cheah JH, Clemons PA, Shamji A, et al. A genetic basis for the variation in the vulnerability of cancer to DNA damage. Nature Communications. 7: 11428. PMID 27109210 DOI: 10.1038/Ncomms11428 |
0.693 |
|
| 2016 |
Hanaford AR, Archer TC, Price A, Kahlert UD, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dančík V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees M, Shamji AF, et al. DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27012813 DOI: 10.1158/1078-0432.Ccr-15-3011 |
0.719 |
|
| 2016 |
Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A stimulates human beta-cell proliferation. Diabetes. PMID 26953159 DOI: 10.2337/Db15-1127 |
0.601 |
|
| 2016 |
Sykes DB, Kfoury YS, Mercier F, Wawer M, Schajnovitz A, Meyer H, Pierce KA, Stoeckigt D, Clish CB, Clemons PA, Janzer A, Scadden DT. Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia Blood. 128: 1656-1656. DOI: 10.1182/Blood.V128.22.1656.1656 |
0.372 |
|
| 2016 |
Tseng Y, Keskula P, Hong AL, Gill S, Cheah JH, Kryukov GV, Tsherniak A, Vazquez F, Cowley G, Oh C, Peng A, Sayeed A, Deasy R, Ronning P, Kantoff P, ... ... Clemons PA, et al. Abstract B26: Accelerating prediction of tumor vulnerabilities using next-generation cancer models Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B26 |
0.684 |
|
| 2016 |
Raghavan S, Gill S, Aguirre AJ, Tseng YM, Peng A, Keskula P, Wu X, Oh C, Cheah J, Kryukov G, Sicinska E, Wolpin BM, Kulke MH, Fuchs CS, Clemons P, et al. Abstract B13: Human pancreatic cancer organoids for functional dependency profiling Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Pdx16-B13 |
0.685 |
|
| 2016 |
Hong AL, Cowley GS, Tseng Y, Cheah JH, Jonas O, Doshi MB, Kynnap BD, Oh C, Meyer S, Clemons P, Burger M, Vazquez F, Weir B, Kryukov GV, Church A, et al. Abstract B38: Developing a functional genomics platform to interrogate rare pediatric cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-B38 |
0.581 |
|
| 2016 |
Tseng Y, Hong A, Keskula P, Gill S, Cheah J, Kryukov G, Tsherniak A, Vazquez F, Cowley G, Oh C, Peng A, Sayeed A, Deasy R, Ronning P, Kantoff P, ... ... Clemons P, et al. Abstract 4367: Accelerating prediction of tumor vulnerabilities using next-generation cancer models Cancer Research. 76: 4367-4367. DOI: 10.1158/1538-7445.Am2016-4367 |
0.693 |
|
| 2016 |
Hanaford AR, Archer TC, Price A, Kahlert U, Maciaczyk J, Guido N, Kim W, Ehrenberger T, Clemons P, Dancik V, Seashore-Ludlow B, Viswanathan V, Stewart M, Rees M, Shamji A, et al. Abstract 2476: DiSCoVERing innovative therapies for rare tumors: Combining genetically accurate disease models with advanced in silico analysis to identify novel therapeutic targets Cancer Research. 76: 2476-2476. DOI: 10.1158/1538-7445.Am2016-2476 |
0.483 |
|
| 2016 |
Speyer G, Dhruv H, Kiefer J, Schreiber S, Clemons P, Berens ME, Kim S. Abstract 1520: Identifying differential dependency networks accounting for response to NEDD8-inhibitor in large-scale cancer cell line data Cancer Research. 76: 1520-1520. DOI: 10.1158/1538-7445.Am2016-1520 |
0.575 |
|
| 2016 |
Hanaford A, Archer T, Price A, Kahlert U, Maciaczyk J, Nikkhah G, Kim JW, Ehrenberger T, Clemons PA, Dančík V, Seashore-Ludlow B, Viswanathan V, Stewart ML, Rees MG, Shamji A, et al. MB-103DiSCoVERing INNOVATIVE THERAPIES: COMBINING GENETICALLY ACCURATE DISEASE MODELS OF MEDULLOBLASTOMA WITH ADVANCED IN SILICO ANALYSIS TO IDENTIFY NOVEL THERAPEUTIC TARGETS Neuro-Oncology. 18: iii120.3-iii120. DOI: 10.1093/Neuonc/Now076.98 |
0.699 |
|
| 2015 |
Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, ... ... Clemons PA, et al. Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Nature Chemical Biology. PMID 26656090 DOI: 10.1038/Nchembio.1986 |
0.827 |
|
| 2015 |
de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nature Chemical Biology. PMID 26656089 DOI: 10.1038/Nchembio.1984 |
0.826 |
|
| 2015 |
Seashore-Ludlow B, Rees MG, Cheah JH, Cokol M, Price EV, Coletti ME, Jones V, Bodycombe NE, Soule CK, Gould J, Alexander B, Li A, Montgomery P, Wawer MJ, Kuru N, ... ... Clemons PA, et al. Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset. Cancer Discovery. 5: 1210-23. PMID 26482930 DOI: 10.1158/2159-8290.Cd-15-0235 |
0.784 |
|
| 2015 |
Kuo SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G, Dan?ík V, Kuballa P, Latorre I, Conway KL, Sarkar S, Maetzel D, Jaenisch R, Clemons PA, Schreiber SL, Shamji AF, et al. Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. Proceedings of the National Academy of Sciences of the United States of America. PMID 26195741 DOI: 10.1073/Pnas.1512289112 |
0.714 |
|
| 2015 |
Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/J.Cell.2015.05.023 |
0.729 |
|
| 2015 |
Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dan?ík V, Ciarlo C, Paulk J, ... ... Clemons PA, et al. Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling. Journal of the American Chemical Society. 137: 7929-34. PMID 26042473 DOI: 10.1021/Jacs.5B04284 |
0.8 |
|
| 2015 |
Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, ... ... Clemons PA, et al. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Reports. PMID 25660025 DOI: 10.1016/J.Celrep.2015.01.017 |
0.799 |
|
| 2015 |
Burns SM, Vetere A, Walpita D, Dan?ík V, Khodier C, Perez J, Clemons PA, Wagner BK, Altshuler D. High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function. Cell Metabolism. 21: 126-37. PMID 25565210 DOI: 10.1016/J.Cmet.2014.12.010 |
0.596 |
|
| 2015 |
Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, et al. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discovery. 5: 154-67. PMID 25501949 DOI: 10.1158/2159-8290.Cd-14-0552 |
0.737 |
|
| 2015 |
Johannessen CM, Clemons PA, Wagner BK. Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery. Trends in Genetics : Tig. 31: 16-23. PMID 25498789 DOI: 10.1016/J.Tig.2014.11.002 |
0.684 |
|
| 2015 |
Howe EA, de Souza A, Lahr DL, Chatwin S, Montgomery P, Alexander BR, Nguyen DT, Cruz Y, Stonich DA, Walzer G, Rose JT, Picard SC, Liu Z, Rose JN, Xiang X, ... ... Clemons PA, et al. BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types. Nucleic Acids Research. 43: D1163-70. PMID 25477388 DOI: 10.1093/Nar/Gku1244 |
0.554 |
|
| 2015 |
Zhou AY, Martins MM, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, et al. Abstract B48: Identification of novel drug interactions with MYC via a quantitative chemical-genetic interaction map Molecular Cancer Research. 13. DOI: 10.1158/1557-3125.Myc15-B48 |
0.733 |
|
| 2015 |
Zhou AY, Martins MM, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, et al. Abstract B44: A systems approach combining genomics, advocacy, and emerging novel therapeutics to address triple-negative breast cancer (TNBC) outcomes disparities Cancer Epidemiology, Biomarkers & Prevention. 24. DOI: 10.1158/1538-7755.Disp14-B44 |
0.693 |
|
| 2015 |
Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, et al. Abstract PR15: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-Pr15 |
0.745 |
|
| 2015 |
Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji A, et al. Abstract PR07: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr07 |
0.745 |
|
| 2015 |
Waal Ld, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, et al. Abstract C136: Identification of selective cancer cytotoxic modulators of phosphodiesterase 3a by predictive chemogenomics Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C136 |
0.816 |
|
| 2015 |
Ferrer-Luna R, Ramkissoon SH, Ramkissoon LA, Lamothe R, Cheah JH, Schumacher SE, Haidar S, Clemons PA, Shamji A, Ligon KL, Beroukhim R. Abstract B66: Identification of genetic and non-genetic dependencies in glioblastoma cell lines targeted by small molecules Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-B66 |
0.713 |
|
| 2014 |
Jerby-Arnon L, Pfetzer N, Waldman YY, McGarry L, James D, Shanks E, Seashore-Ludlow B, Weinstock A, Geiger T, Clemons PA, Gottlieb E, Ruppin E. Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell. 158: 1199-209. PMID 25171417 DOI: 10.1016/J.Cell.2014.07.027 |
0.385 |
|
| 2014 |
Abeyruwan S, Vempati UD, Küçük-McGinty H, Visser U, Koleti A, Mir A, Sakurai K, Chung C, Bittker JA, Clemons PA, Brudz S, Siripala A, Morales AJ, Romacker M, Twomey D, et al. Evolving BioAssay Ontology (BAO): modularization, integration and applications. Journal of Biomedical Semantics. 5: S5. PMID 25093074 DOI: 10.1186/2041-1480-5-S1-S5 |
0.371 |
|
| 2014 |
Adams DJ, Ito D, Rees MG, Seashore-Ludlow B, Puyang X, Ramos AH, Cheah JH, Clemons PA, Warmuth M, Zhu P, Shamji AF, Schreiber SL. NAMPT is the cellular target of STF-31-like small-molecule probes. Acs Chemical Biology. 9: 2247-54. PMID 25058389 DOI: 10.1021/Cb500347P |
0.756 |
|
| 2014 |
Wawer MJ, Li K, Gustafsdottir SM, Ljosa V, Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E, Taylor B, Grant GB, Hon CS, Duvall JR, Wilson JA, ... ... Clemons PA, et al. Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proceedings of the National Academy of Sciences of the United States of America. 111: 10911-6. PMID 25024206 DOI: 10.1073/Pnas.1410933111 |
0.765 |
|
| 2014 |
Green DV, Clemons PA. Knowledge from Small-Molecule Screening and Profiling Data. Journal of Biomolecular Screening. 19: 611-613. PMID 24842910 DOI: 10.1177/1087057114531209 |
0.373 |
|
| 2014 |
Choudhary A, Hu He K, Mertins P, Udeshi ND, Dan?ík V, Fomina-Yadlin D, Kubicek S, Clemons PA, Schreiber SL, Carr SA, Wagner BK. Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming. Plos One. 9: e95194. PMID 24759943 DOI: 10.1371/Journal.Pone.0095194 |
0.653 |
|
| 2014 |
Wawer MJ, Jaramillo DE, Dan?ík V, Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, Clemons PA. Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles. Journal of Biomolecular Screening. 19: 738-748. PMID 24710340 DOI: 10.1177/1087057114530783 |
0.817 |
|
| 2014 |
Dan?ík V, Carrel H, Bodycombe NE, Seiler KP, Fomina-Yadlin D, Kubicek ST, Hartwell K, Shamji AF, Wagner BK, Clemons PA. Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses. Journal of Biomolecular Screening. 19: 771-781. PMID 24464433 DOI: 10.1177/1087057113520226 |
0.783 |
|
| 2014 |
de Souza A, Bittker JA, Lahr DL, Brudz S, Chatwin S, Oprea TI, Waller A, Yang JJ, Southall N, Guha R, Schürer SC, Vempati UD, Southern MR, Dawson ES, Clemons PA, et al. An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines. Journal of Biomolecular Screening. 19: 614-627. PMID 24441647 DOI: 10.1177/1087057113517139 |
0.319 |
|
| 2014 |
Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Regulation of ferroptotic cancer cell death by GPX4. Cell. 156: 317-31. PMID 24439385 DOI: 10.1016/J.Cell.2013.12.010 |
0.789 |
|
| 2014 |
Gutierrez A, Pan L, Groen RWJ, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, et al. Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia Journal of Clinical Investigation. 124: 644-655. PMID 24401270 DOI: 10.1172/Jci65093 |
0.578 |
|
| 2014 |
Gutierrez A, Pan L, Groen R, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, Verplank L, An F, et al. Abstract IA8: A new class of drugs active in T-ALL is revealed in a zebrafish screen Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Modorg-Ia8 |
0.414 |
|
| 2013 |
Gustafsdottir SM, Ljosa V, Sokolnicki KL, Anthony Wilson J, Walpita D, Kemp MM, Petri Seiler K, Carrel HA, Golub TR, Schreiber SL, Clemons PA, Carpenter AE, Shamji AF. Multiplex cytological profiling assay to measure diverse cellular states. Plos One. 8: e80999. PMID 24312513 DOI: 10.1371/Journal.Pone.0080999 |
0.739 |
|
| 2013 |
Hartwell KA, Miller PG, Mukherjee S, Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M, Järås M, Puram R, Dancik V, Al-Shahrour F, Kindler T, Tothova Z, Chattopadhyay S, ... ... Clemons PA, et al. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nature Chemical Biology. 9: 840-8. PMID 24161946 DOI: 10.1038/Nchembio.1367 |
0.806 |
|
| 2013 |
Ljosa V, Caie PD, Ter Horst R, Sokolnicki KL, Jenkins EL, Daya S, Roberts ME, Jones TR, Singh S, Genovesio A, Clemons PA, Carragher NO, Carpenter AE. Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment. Journal of Biomolecular Screening. 18: 1321-9. PMID 24045582 DOI: 10.1177/1087057113503553 |
0.397 |
|
| 2013 |
Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, ... ... Clemons PA, et al. An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell. 154: 1151-61. PMID 23993102 DOI: 10.1016/J.Cell.2013.08.003 |
0.802 |
|
| 2013 |
Li G, Diogo D, Wu D, Spoonamore J, Dancik V, Franke L, Kurreeman F, Rossin EJ, Duclos G, Hartland C, Zhou X, Li K, Liu J, De Jager PL, Siminovitch KA, ... ... Clemons PA, et al. Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway. Plos Genetics. 9: e1003487. PMID 23696745 DOI: 10.1371/Journal.Pgen.1003487 |
0.362 |
|
| 2013 |
Mulrooney CA, Lahr DL, Quintin MJ, Youngsaye W, Moccia D, Asiedu JK, Mulligan EL, Akella LB, Marcaurelle LA, Montgomery P, Bittker JA, Clemons PA, Brudz S, Dandapani S, Duvall JR, et al. An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries. Journal of Computer-Aided Molecular Design. 27: 455-68. PMID 23585218 DOI: 10.1007/S10822-013-9641-Y |
0.363 |
|
| 2013 |
Schenone M, Dan?ík V, Wagner BK, Clemons PA. Target identification and mechanism of action in chemical biology and drug discovery. Nature Chemical Biology. 9: 232-40. PMID 23508189 DOI: 10.1038/Nchembio.1199 |
0.667 |
|
| 2013 |
Ferrer-Luna R, Ramkissoon S, Cheah J, Lamothe R, Schumacher S, Shamji A, Clemons P, Reardon D, Wen P, Schreiber S, Ligon K, Beroukhim R. Abstract A103: High-throughput genomic and chemical screening in glioblastoma cell lines. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-A103 |
0.726 |
|
| 2012 |
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, ... ... Clemons PA, et al. Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL. Cell. 150: 575-89. PMID 22863010 DOI: 10.1016/J.Cell.2012.06.032 |
0.669 |
|
| 2012 |
Kubicek S, Gilbert JC, Fomina-Yadlin D, Gitlin AD, Yuan Y, Wagner FF, Holson EB, Luo T, Lewis TA, Taylor B, Gupta S, Shamji AF, Wagner BK, Clemons PA, Schreiber SL. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 5364-9. PMID 22434908 DOI: 10.1073/Pnas.1201079109 |
0.804 |
|
| 2012 |
Walpita D, Hasaka T, Spoonamore J, Vetere A, Takane KK, Fomina-Yadlin D, Fiaschi-Taesch N, Shamji A, Clemons PA, Stewart AF, Schreiber SL, Wagner BK. A human islet cell culture system for high-throughput screening. Journal of Biomolecular Screening. 17: 509-18. PMID 22156222 DOI: 10.1177/1087057111430253 |
0.781 |
|
| 2012 |
Swamidass SJ, Calhoun BT, Bittker JA, Bodycombe NE, Clemons PA. Utility-aware screening with clique-oriented prioritization. Journal of Chemical Information and Modeling. 52: 29-37. PMID 22117901 DOI: 10.1021/Ci2003285 |
0.345 |
|
| 2012 |
Gutierrez A, Kentsis A, Pan L, Baleydier F, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons PA, VerPlank L, An WF, Burbank J, et al. Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor Blood. 120: 3558-3558. DOI: 10.1182/Blood.V120.21.3558.3558 |
0.408 |
|
| 2011 |
Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK. A small-molecule screening strategy to identify suppressors of statin myopathy. Acs Chemical Biology. 6: 900-4. PMID 21732624 DOI: 10.1021/Cb200206W |
0.62 |
|
| 2011 |
Seiler KP, Bodycombe NE, Hawkins T, Shell R, Lemon A, de Souza A, Clemons PA. Master data management: getting your house in order. Combinatorial Chemistry & High Throughput Screening. 14: 749-56. PMID 21631416 DOI: 10.2174/138620711796957189 |
0.358 |
|
| 2011 |
Hung AW, Ramek A, Wang Y, Kaya T, Wilson JA, Clemons PA, Young DW. Route to three-dimensional fragments using diversity-oriented synthesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 6799-804. PMID 21482811 DOI: 10.1073/Pnas.1015271108 |
0.749 |
|
| 2011 |
Clemons PA, Wilson JA, Dan?ík V, Muller S, Carrinski HA, Wagner BK, Koehler AN, Schreiber SL. Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections. Proceedings of the National Academy of Sciences of the United States of America. 108: 6817-22. PMID 21482810 DOI: 10.1073/Pnas.1015024108 |
0.803 |
|
| 2011 |
Bochner BR, Siri M, Huang RH, Noble S, Lei XH, Clemons PA, Wagner BK. Assay of the multiple energy-producing pathways of mammalian cells. Plos One. 6: e18147. PMID 21455318 DOI: 10.1371/Journal.Pone.0018147 |
0.611 |
|
| 2011 |
Kim YK, Lee JS, Bi X, Ha HH, Ng SH, Ahn YH, Lee JJ, Wagner BK, Clemons PA, Chang YT. The binding of fluorophores to proteins depends on the cellular environment. Angewandte Chemie (International Ed. in English). 50: 2761-3. PMID 21370369 DOI: 10.1002/Anie.201007626 |
0.624 |
|
| 2011 |
Shaw SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A, Schreiber SL. Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes. Proceedings of the National Academy of Sciences of the United States of America. 108: 492-7. PMID 21183721 DOI: 10.1073/Pnas.1016789108 |
0.542 |
|
| 2011 |
Kim YK, Lee J, Bi X, Ha H, Ng SH, Ahn Y, Lee J, Wagner BK, Clemons PA, Chang Y. Cover Picture: The Binding of Fluorophores to Proteins Depends on the Cellular Environment (Angew. Chem. Int. Ed. 12/2011) Angewandte Chemie International Edition. 50: 2649-2649. DOI: 10.1002/Anie.201101113 |
0.571 |
|
| 2011 |
Kim YK, Lee J, Bi X, Ha H, Ng SH, Ahn Y, Lee J, Wagner BK, Clemons PA, Chang Y. Titelbild: The Binding of Fluorophores to Proteins Depends on the Cellular Environment (Angew. Chem. 12/2011) Angewandte Chemie. 123: 2699-2699. DOI: 10.1002/Ange.201101113 |
0.567 |
|
| 2010 |
Muncipinto G, Kaya T, Wilson JA, Kumagai N, Clemons PA, Schreiber SL. Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions. Organic Letters. 12: 5230-3. PMID 20977261 DOI: 10.1021/Ol102266J |
0.609 |
|
| 2010 |
Clemons PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, Schreiber SL. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles. Proceedings of the National Academy of Sciences of the United States of America. 107: 18787-92. PMID 20956335 DOI: 10.1073/Pnas.1012741107 |
0.813 |
|
| 2010 |
Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/Nbt0910-904 |
0.806 |
|
| 2010 |
Fomina-Yadlin D, Kubicek S, Walpita D, Dancik V, Hecksher-Sørensen J, Bittker JA, Sharifnia T, Shamji A, Clemons PA, Wagner BK, Schreiber SL. Small-molecule inducers of insulin expression in pancreatic alpha-cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 15099-104. PMID 20696901 DOI: 10.1073/Pnas.1010018107 |
0.783 |
|
| 2010 |
Dancík V, Seiler KP, Young DW, Schreiber SL, Clemons PA. Distinct biological network properties between the targets of natural products and disease genes. Journal of the American Chemical Society. 132: 9259-61. PMID 20565092 DOI: 10.1021/Ja102798T |
0.647 |
|
| 2010 |
Chou DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, Wagner BK. Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis. Acs Chemical Biology. 5: 729-34. PMID 20550176 DOI: 10.1021/Cb100129D |
0.793 |
|
| 2010 |
Swamidass SJ, Bittker JA, Bodycombe NE, Ryder SP, Clemons PA. An economic framework to prioritize confirmatory tests after a high-throughput screen. Journal of Biomolecular Screening. 15: 680-6. PMID 20547534 DOI: 10.1177/1087057110372803 |
0.325 |
|
| 2010 |
Pizzirani D, Kaya T, Clemons PA, Schreiber SL. Stereochemical and skeletal diversity arising from amino propargylic alcohols Organic Letters. 12: 2822-2825. PMID 20481457 DOI: 10.1021/Ol100914B |
0.423 |
|
| 2010 |
Wen QJ, Silver S, Lewis T, Ponduru S, Dancik V, Goldenson B, Bray M, Carpenter A, Clemons P, Root D, Stern A, Gould R, Crispino J. A Kinome shRNA Screen to Identify Pathways That Regulate Megakaryocyte Polyploidization and New Targets for Differentiation Therapy Blood. 116: 89-89. DOI: 10.1182/Blood.V116.21.89.89 |
0.432 |
|
| 2009 |
Kelly KA, Shaw SY, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R. Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integrative Biology : Quantitative Biosciences From Nano to Macro. 1: 311-7. PMID 20023731 DOI: 10.1039/B821775K |
0.534 |
|
| 2009 |
Wagner BK, Clemons PA. Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling. Current Opinion in Chemical Biology. 13: 539-48. PMID 19825513 DOI: 10.1016/J.Cbpa.2009.09.018 |
0.673 |
|
| 2009 |
Tanikawa T, Fridman M, Zhu W, Faulk B, Joseph IC, Kahne D, Wagner BK, Clemons PA. Using biological performance similarity to inform disaccharide library design. Journal of the American Chemical Society. 131: 5075-83. PMID 19298063 DOI: 10.1021/Ja806583Y |
0.645 |
|
| 2008 |
Petri Seiler K, Kuehn H, Pat Happ M, Decaprio D, Clemons PA. Using ChemBank to probe chemical biology. Current Protocols in Bioinformatics / Editoral Board, Andreas D. Baxevanis ... [Et Al.]. Unit 14.5. PMID 18551413 DOI: 10.1002/0471250953.Bi1405S22 |
0.429 |
|
| 2008 |
Wagner BK, Carrinski HA, Ahn YH, Kim YK, Gilbert TJ, Fomina DA, Schreiber SL, Chang YT, Clemons PA. Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening. Journal of the American Chemical Society. 130: 4208-9. PMID 18327938 DOI: 10.1021/Ja077656D |
0.748 |
|
| 2008 |
Seiler KP, George GA, Happ MP, Bodycombe NE, Carrinski HA, Norton S, Brudz S, Sullivan JP, Muhlich J, Serrano M, Ferraiolo P, Tolliday NJ, Schreiber SL, Clemons PA. ChemBank: a small-molecule screening and cheminformatics resource database. Nucleic Acids Research. 36: D351-9. PMID 17947324 DOI: 10.1093/Nar/Gkm843 |
0.559 |
|
| 2007 |
Bender A, Young DW, Jenkins JL, Serrano M, Mikhailov D, Clemons PA, Davies JW. Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint. Combinatorial Chemistry & High Throughput Screening. 10: 719-31. PMID 18045083 DOI: 10.2174/138620707782507313 |
0.639 |
|
| 2007 |
Duffner JL, Clemons PA, Koehler AN. A pipeline for ligand discovery using small-molecule microarrays. Current Opinion in Chemical Biology. 11: 74-82. PMID 17169601 DOI: 10.1016/J.Cbpa.2006.11.031 |
0.71 |
|
| 2006 |
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, ... Clemons PA, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.). 313: 1929-35. PMID 17008526 DOI: 10.1126/Science.1132939 |
0.604 |
|
| 2006 |
Tolliday N, Clemons PA, Ferraiolo P, Koehler AN, Lewis TA, Li X, Schreiber SL, Gerhard DS, Eliasof S. Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics. Cancer Research. 66: 8935-42. PMID 16982730 DOI: 10.1158/0008-5472.Can-06-2552 |
0.742 |
|
| 2006 |
Kelly KA, Clemons PA, Yu AM, Weissleder R. High-throughput identification of phage-derived imaging agents. Molecular Imaging. 5: 24-30. PMID 16779967 DOI: 10.2310/7290.2006.00003 |
0.381 |
|
| 2005 |
Forman JJ, Clemons PA, Schreiber SL, Haggarty SJ. SpectralNET--an application for spectral graph analysis and visualization. Bmc Bioinformatics. 6: 260. PMID 16236170 DOI: 10.1186/1471-2105-6-260 |
0.61 |
|
| 2004 |
Haggarty SJ, Clemons PA, Wong JC, Schreiber SL. Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors. Combinatorial Chemistry & High Throughput Screening. 7: 669-76. PMID 15578929 DOI: 10.2174/1386207043328319 |
0.745 |
|
| 2004 |
Kim YK, Arai MA, Arai T, Lamenzo JO, Dean EF, Patterson N, Clemons PA, Schreiber SL. Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space. Journal of the American Chemical Society. 126: 14740-5. PMID 15535697 DOI: 10.1021/Ja048170P |
0.63 |
|
| 2004 |
Wagner BK, Haggarty SJ, Clemons PA. Chemical genomics: probing protein function using small molecules. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 4: 313-20. PMID 15462609 DOI: 10.2165/00129785-200404050-00004 |
0.731 |
|
| 2004 |
Clemons PA. Complex phenotypic assays in high-throughput screening. Current Opinion in Chemical Biology. 8: 334-8. PMID 15183333 DOI: 10.1016/J.Cbpa.2004.04.002 |
0.437 |
|
| 2003 |
Haggarty SJ, Clemons PA, Schreiber SL. Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations. Journal of the American Chemical Society. 125: 10543-5. PMID 12940736 DOI: 10.1021/Ja035413P |
0.652 |
|
| 2002 |
Clemons PA, Gladstone BG, Seth A, Chao ED, Foley MA, Schreiber SL. Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. Chemistry & Biology. 9: 49-61. PMID 11841938 DOI: 10.1016/S1074-5521(02)00085-6 |
0.463 |
|
| 2002 |
Wagner BK, Clemons PA. Dual-purpose drug discovery Trends in Biotechnology. 20: 492-493. DOI: 10.1016/S0167-7799(02)02097-8 |
0.599 |
|
| 2002 |
Wagner BK, Clemons PA. An even-handed approach Trends in Biotechnology. 20: 53. DOI: 10.1016/S0167-7799(01)01927-8 |
0.595 |
|
| 2001 |
Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2 |
0.815 |
|
| 2001 |
Blackwell HE, Clemons PA, Schreiber SL. Exploiting site-site interactions on solid support to generate dimeric molecules. Organic Letters. 3: 1185-8. PMID 11348190 DOI: 10.1021/Ol015647I |
0.624 |
|
| 2001 |
Clemons PA, Wagner BK. Hay in a needlestack? Trends in Biotechnology. 19: 435-436. DOI: 10.1016/S0167-7799(01)01848-0 |
0.512 |
|
| 2001 |
Wagner BK, Clemons PA. Better signaling through chemistry Trends in Biotechnology. 19: 127. DOI: 10.1016/S0167-7799(01)01611-0 |
0.593 |
|
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