Kathryn M. Appleton, Ph.D.
Affiliations: | 2014 | Medical University of South Carolina, Charleston, SC, United States |
Area:
Pharmacology, Endocrinology BiologyGoogle:
"Kathryn Appleton"Parents
Sign in to add mentor| Yuri Peterson | grad student | 2014 | MUSC | |
| (Receptor and Ligand Determinants in Arrestin Function.) | ||||
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Publications
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| Strungs E, Appleton K, Kwon J, et al. (2018) Application of Intramolecular FlAsH-BRET to the Classification Arrestin Activation Modes Protocol Exchange |
| Lee MH, Appleton KM, El-Shewy HM, et al. (2016) S1P in HDL Promotes Interaction Between SR-BI and S1PR1 and Activates S1PR1-Mediated Biological Functions: Calcium Flux and S1PR1 Internalization. Journal of Lipid Research |
| Haak AJ, Appleton KM, Lisabeth EM, et al. (2016) Pharmacological inhibition of Myocardin-related transcription factor pathway blocks lung metastases of RhoC overexpressing melanoma. Molecular Cancer Therapeutics |
| Lee MH, Appleton KM, Strungs EG, et al. (2016) The conformational signature of β-arrestin2 predicts its trafficking and signalling functions. Nature |
| Appleton KM, Bigham KJ, Lindsey CC, et al. (2014) Development of inhibitors of heterotrimeric Gαi subunits. Bioorganic & Medicinal Chemistry. 22: 3423-34 |
| Raymond JR, Appleton KM, Pierce JY, et al. (2014) Suppression of GNAI2 message in ovarian cancer. Journal of Ovarian Research. 7: 6 |
| Wilson PC, Lee MH, Appleton KM, et al. (2013) The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers. The Journal of Biological Chemistry. 288: 18872-84 |
| Appleton KM, Luttrell LM. (2013) Emergent biological properties of arrestin pathway-selective biased agonism. Journal of Receptor and Signal Transduction Research. 33: 153-61 |
| Appleton KM, Lee MH, Alele C, et al. (2013) Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity. Methods in Enzymology. 522: 229-62 |
| Leonard AP, Appleton KM, Luttrell LM, et al. (2013) A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 19: 150-70 |