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Richard L. Schowen

Affiliations: 
Chemistry University of Kansas, Lawrence, KS, United States 
Area:
Organic chemistry and enzymology: reaction mechanisms, bioorganic chemistry, catalysis, isotope effects
Website:
http://www.chem.ku.edu/people/faculty/dschowen
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"Richard L. Schowen"
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Parents

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C. Gardner Swain grad student 1958-1962 MIT
 (The use of isotope effects to determine the mechanism of nucleophilic displacement at silicon)

Children

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Daniel M. Quinn grad student 1977 University of Kansas
W Phillip Huskey grad student 1985 University of Kansas
Michael P. Garoutte grad student 1989-1995 University of Kansas
Roger L. Mac Kinnon grad student 2001 University of Kansas
Ashley D. Wilson grad student 2001 University of Kansas
Andrew Bennet post-doc University of Kansas

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Publications

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Lopalco A, Dalwadi G, Niu S, et al. (2015) Mechanism of Decarboxylation of Pyruvic Acid in the Presence of Hydrogen Peroxide. Journal of Pharmaceutical Sciences
Anandarajah K, Schowen KB, Schowen RL. (2013) Isotope Effects and Temperature Dependences in the Action of the Glucose Dehydrogenase of the Mesophilic Bacterium Bacillus megaterium. Journal of Physical Organic Chemistry. 26
Cai S, Fang J, Li QS, et al. (2010) Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. Role of lysyl and tyrosyl residues of the C-terminal extension. Biochemistry. 49: 8434-41
Limbach HH, Schowen KB, Schowen RL. (2010) Heavy atom motions and tunneling in hydrogen transfer reactions: The importance of the pre-tunneling state Journal of Physical Organic Chemistry. 23: 586-605
Li QS, Cai S, Fang J, et al. (2009) Evaluation of NAD(H) analogues as selective inhibitors for Trypanosoma cruzi S-adenosylhomocysteine hydrolase. Nucleosides, Nucleotides & Nucleic Acids. 28: 473-84
Li QS, Cai S, Fang J, et al. (2008) Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability. Biochemistry. 47: 4983-91
Schowen RL. (2007) Isotopic and other studies on the molecular origins of substrate regulation of some pyruvate decarboxylases: a reconsideration. Isotopes in Environmental and Health Studies. 43: 1-16
Li QS, Cai S, Borchardt RT, et al. (2007) Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes. Biochemistry. 46: 5798-809
Gradinaru R, Schowen R, Ghisla S. (2007) Solvent isotope effects in reactions of human medium-chain acyl-CoA dehydrogenase active site mutants Biochemistry. 46: 2497-2509
Schowen RL. (2007) The use of solvent isotope effects in the pursuit of enzyme mechanisms Journal of Labelled Compounds and Radiopharmaceuticals. 50: 1052-1062
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