| Year |
Citation |
Score |
| 2023 |
Chen R, Li J, Wang J, Ibarra I, Cheng X, Luecken M, Liu J, Monavarfeshani A, Yan W, Zheng Y, Zuo Z, Colborn S, Cortez B, Owen LA, Tran N, ... ... Chen S, et al. Integrated multi-omics single cell atlas of the human retina. Research Square. PMID 38014002 DOI: 10.21203/rs.3.rs-3471275/v1 |
0.763 |
|
| 2023 |
Wang J, Cheng X, Liang Q, Owen LA, Lu J, Zheng Y, Wang M, Chen S, DeAngelis MM, Li Y, Chen R. Single-cell multiomics of the human retina reveals hierarchical transcription factor collaboration in mediating cell type-specific effects of genetic variants on gene regulation. Genome Biology. 24: 269. PMID 38012720 DOI: 10.1186/s13059-023-03111-8 |
0.381 |
|
| 2023 |
Zheng Y, Sun C, Zhang X, Ruzycki PA, Chen S. Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms. Elife. 12. PMID 37963072 DOI: 10.7554/eLife.87147 |
0.479 |
|
| 2023 |
Sun C, Ruzycki PA, Chen S. Rho enhancers play unexpectedly minor roles in Rhodopsin transcription and rod cell integrity. Scientific Reports. 13: 12899. PMID 37558693 DOI: 10.1038/s41598-023-39979-6 |
0.503 |
|
| 2023 |
Sun C, Chen S. Gene Augmentation for Autosomal Dominant CRX-Associated Retinopathies. Advances in Experimental Medicine and Biology. 1415: 135-141. PMID 37440026 DOI: 10.1007/978-3-031-27681-1_21 |
0.457 |
|
| 2023 |
Occelli LM, Tran NM, Chen S, Petersen-Jones SM. Cat LCA-CRX Model, Homozygous for an Antimorphic Mutation Has a Unique Phenotype. Translational Vision Science & Technology. 12: 15. PMID 37351895 DOI: 10.1167/tvst.12.6.15 |
0.758 |
|
| 2023 |
Shepherdson JL, Friedman RZ, Zheng Y, Sun C, Oh IY, Granas DM, Cohen BA, Chen S, White MA. Pathogenic variants in CRX have distinct -regulatory effects on enhancers and silencers in photoreceptors. Biorxiv : the Preprint Server For Biology. PMID 37292699 DOI: 10.1101/2023.05.27.542576 |
0.401 |
|
| 2023 |
Sun C, Chen S. Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development. Frontiers in Molecular Neuroscience. 16: 1134839. PMID 37181651 DOI: 10.3389/fnmol.2023.1134839 |
0.547 |
|
| 2023 |
Zheng Y, Sun C, Zhang X, Ruzycki PA, Chen S. Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms. Biorxiv : the Preprint Server For Biology. PMID 36778408 DOI: 10.1101/2023.02.01.526652 |
0.499 |
|
| 2022 |
Sun C, Zhang X, Ruzycki PA, Chen S. Essential Functions of MLL1 and MLL2 in Retinal Development and Cone Cell Maintenance. Frontiers in Cell and Developmental Biology. 10: 829536. PMID 35223853 DOI: 10.3389/fcell.2022.829536 |
0.448 |
|
| 2020 |
Enright JM, Zhang S, Thebeau C, Siebert E, Jin A, Gadiraju V, Zhang X, Chen S, Semenkovich CF, Rajagopal R. Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression. Journal of Clinical Medicine. 10. PMID 33396512 DOI: 10.3390/jcm10010126 |
0.382 |
|
| 2019 |
Oh IY, Chen S. High-Throughput Analysis of Retinal Cis-Regulatory Networks by Massively Parallel Reporter Assays. Advances in Experimental Medicine and Biology. 1185: 359-364. PMID 31884638 DOI: 10.1007/978-3-030-27378-1_59 |
0.495 |
|
| 2019 |
Chen F, Zheng A, Li F, Wen S, Chen S, Tao Z. Screening and identification of potential target genes in head and neck cancer using bioinformatics analysis. Oncology Letters. 18: 2955-2966. PMID 31452775 DOI: 10.3892/ol.2019.10616 |
0.325 |
|
| 2018 |
Brightman DS, Grant RL, Ruzycki PA, Suzuki R, Hennig AK, Chen S. MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Scientific Reports. 8: 11902. PMID 30093671 DOI: 10.1038/S41598-018-30355-3 |
0.48 |
|
| 2018 |
Ruzycki PA, Zhang X, Chen S. CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sites. Epigenetics & Chromatin. 11: 42. PMID 30068366 DOI: 10.1186/S13072-018-0212-2 |
0.44 |
|
| 2017 |
Ruzycki PA, Linne CD, Hennig AK, Chen S. Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice. Investigative Ophthalmology & Visual Science. 58: 4644-4653. PMID 28903150 DOI: 10.1167/Iovs.17-22075 |
0.536 |
|
| 2016 |
Occelli LM, Tran NM, Narfström K, Chen S, Petersen-Jones SM. CrxRdy Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis. Investigative Ophthalmology & Visual Science. 57: 3780-3792. PMID 27427859 DOI: 10.1167/Iovs.16-19444 |
0.776 |
|
| 2016 |
Brightman DS, Razafsky D, Potter C, Hodzic D, Chen S. Nrl-Cre transgenic mouse mediates loxP recombination in developing rod photoreceptors. Genesis (New York, N.Y. : 2000). PMID 26789558 DOI: 10.1002/Dvg.22918 |
0.467 |
|
| 2015 |
Ruzycki PA, Tran NM, Kefalov VJ, Kolesnikov AV, Chen S. Graded gene expression changes determine phenotype severity in mouse models of CRX-associated retinopathies. Genome Biology. 16: 171. PMID 26324254 DOI: 10.1186/S13059-015-0732-Z |
0.789 |
|
| 2014 |
Masuda T, Zhang X, Berlinicke C, Wan J, Yerrabelli A, Conner EA, Kjellstrom S, Bush R, Thorgeirsson SS, Swaroop A, Chen S, Zack DJ. The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15356-68. PMID 25392503 DOI: 10.1523/Jneurosci.2089-14.2014 |
0.677 |
|
| 2014 |
Tran NM, Chen S. Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 243: 1153-66. PMID 24888636 DOI: 10.1002/Dvdy.24151 |
0.794 |
|
| 2014 |
Tran NM, Zhang A, Zhang X, Huecker JB, Hennig AK, Chen S. Mechanistically distinct mouse models for CRX-associated retinopathy. Plos Genetics. 10: e1004111. PMID 24516401 DOI: 10.1371/Journal.Pgen.1004111 |
0.775 |
|
| 2013 |
Hennig AK, Peng GH, Chen S. Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression. Plos One. 8: e69721. PMID 23922782 DOI: 10.1371/Journal.Pone.0069721 |
0.544 |
|
| 2013 |
Peng GH, Chen S. Double chromatin immunoprecipitation: analysis of target co-occupancy of retinal transcription factors. Methods in Molecular Biology (Clifton, N.J.). 935: 311-28. PMID 23150378 DOI: 10.1007/978-1-62703-080-9_22 |
0.563 |
|
| 2012 |
Peng GH, Chen S. Revealing looping organization of mammalian photoreceptor genes using chromosome conformation capture (3C) assays. Methods in Molecular Biology (Clifton, N.J.). 884: 305-18. PMID 22688716 DOI: 10.1007/978-1-61779-848-1_22 |
0.419 |
|
| 2011 |
Rao RC, Hennig AK, Malik MT, Chen DF, Chen S. Epigenetic regulation of retinal development and disease. Journal of Ocular Biology, Diseases, and Informatics. 4: 121-36. PMID 23538488 DOI: 10.1007/S12177-012-9083-0 |
0.515 |
|
| 2011 |
Peng GH, Chen S. Active opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor network. Proceedings of the National Academy of Sciences of the United States of America. 108: 17821-6. PMID 22006320 DOI: 10.1073/Pnas.1109209108 |
0.548 |
|
| 2011 |
Montana CL, Lawrence KA, Williams NL, Tran NM, Peng GH, Chen S, Corbo JC. Transcriptional regulation of neural retina leucine zipper (Nrl), a photoreceptor cell fate determinant. The Journal of Biological Chemistry. 286: 36921-31. PMID 21865162 DOI: 10.1074/Jbc.M111.279026 |
0.802 |
|
| 2011 |
de Melo J, Peng GH, Chen S, Blackshaw S. The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneurons. Development (Cambridge, England). 138: 2325-36. PMID 21558380 DOI: 10.1242/Dev.061846 |
0.579 |
|
| 2010 |
Onishi A, Peng GH, Chen S, Blackshaw S. Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation. Nature Neuroscience. 13: 1059-65. PMID 20729845 DOI: 10.1038/Nn.2618 |
0.512 |
|
| 2010 |
Onishi A, Peng GH, Poth EM, Lee DA, Chen J, Alexis U, de Melo J, Chen S, Blackshaw S. The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival. Proceedings of the National Academy of Sciences of the United States of America. 107: 11579-84. PMID 20534447 DOI: 10.1073/Pnas.1000102107 |
0.57 |
|
| 2009 |
Onishi A, Peng GH, Hsu C, Alexis U, Chen S, Blackshaw S. Pias3-dependent SUMOylation directs rod photoreceptor development. Neuron. 61: 234-46. PMID 19186166 DOI: 10.1016/J.Neuron.2008.12.006 |
0.599 |
|
| 2009 |
Escher P, Gouras P, Roduit R, Tiab L, Bolay S, Delarive T, Chen S, Tsai CC, Hayashi M, Zernant J, Merriam JE, Mermod N, Allikmets R, Munier FL, Schorderet DF. Mutations in NR2E3 can cause dominant or recessive retinal degenerations in the same family. Human Mutation. 30: 342-51. PMID 19006237 DOI: 10.1002/humu.20858 |
0.412 |
|
| 2008 |
Mali RS, Peng GH, Zhang X, Dang L, Chen S, Mitton KP. FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo. Bmc Molecular Biology. 9: 87. PMID 18854042 DOI: 10.1186/1471-2199-9-87 |
0.593 |
|
| 2008 |
Hennig AK, Peng GH, Chen S. Regulation of photoreceptor gene expression by Crx-associated transcription factor network. Brain Research. 1192: 114-33. PMID 17662965 DOI: 10.1016/J.Brainres.2007.06.036 |
0.525 |
|
| 2007 |
Peng GH, Chen S. Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Human Molecular Genetics. 16: 2433-52. PMID 17656371 DOI: 10.1093/Hmg/Ddm200 |
0.543 |
|
| 2007 |
Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. The Journal of Biological Chemistry. 282: 30150-60. PMID 17646170 DOI: 10.1074/Jbc.M705265200 |
0.387 |
|
| 2006 |
Dorval KM, Bobechko BP, Fujieda H, Chen S, Zack DJ, Bremner R. CHX10 targets a subset of photoreceptor genes. The Journal of Biological Chemistry. 281: 744-51. PMID 16236706 DOI: 10.1074/Jbc.M509470200 |
0.698 |
|
| 2005 |
Peng GH, Chen S. Chromatin immunoprecipitation identifies photoreceptor transcription factor targets in mouse models of retinal degeneration: new findings and challenges. Visual Neuroscience. 22: 575-86. PMID 16332268 DOI: 10.1017/S0952523805225063 |
0.647 |
|
| 2005 |
Palhan VB, Chen S, Peng GH, Tjernberg A, Gamper AM, Fan Y, Chait BT, La Spada AR, Roeder RG. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 102: 8472-7. PMID 15932940 DOI: 10.1073/Pnas.0503505102 |
0.502 |
|
| 2005 |
Lerner LE, Peng GH, Gribanova YE, Chen S, Farber DB. Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx. The Journal of Biological Chemistry. 280: 20642-50. PMID 15781457 DOI: 10.1074/Jbc.M500957200 |
0.337 |
|
| 2005 |
Peng GH, Ahmad O, Ahmad F, Liu J, Chen S. The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes. Human Molecular Genetics. 14: 747-64. PMID 15689355 DOI: 10.1093/Hmg/Ddi070 |
0.621 |
|
| 2004 |
Rhee KD, Goureau O, Chen S, Yang XJ. Cytokine-induced activation of signal transducer and activator of transcription in photoreceptor precursors regulates rod differentiation in the developing mouse retina. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9779-88. PMID 15525763 DOI: 10.1523/Jneurosci.1785-04.2004 |
0.3 |
|
| 2004 |
Wang QL, Chen S, Esumi N, Swain PK, Haines HS, Peng G, Melia BM, McIntosh I, Heckenlively JR, Jacobson SG, Stone EM, Swaroop A, Zack DJ. QRX, a novel homeobox gene, modulates photoreceptor gene expression. Human Molecular Genetics. 13: 1025-40. PMID 15028672 DOI: 10.1093/Hmg/Ddh117 |
0.81 |
|
| 2004 |
Pittler SJ, Zhang Y, Chen S, Mears AJ, Zack DJ, Ren Z, Swain PK, Yao S, Swaroop A, White JB. Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity. The Journal of Biological Chemistry. 279: 19800-7. PMID 15001570 DOI: 10.1074/Jbc.M401864200 |
0.68 |
|
| 2004 |
Chen S, Peng GH, Wang X, Smith AC, Grote SK, Sopher BL, La Spada AR. Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization. Human Molecular Genetics. 13: 53-67. PMID 14613968 DOI: 10.1093/Hmg/Ddh005 |
0.544 |
|
| 2003 |
Yoo SY, Pennesi ME, Weeber EJ, Xu B, Atkinson R, Chen S, Armstrong DL, Wu SM, Sweatt JD, Zoghbi HY. SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity. Neuron. 37: 383-401. PMID 12575948 DOI: 10.1016/S0896-6273(02)01190-X |
0.37 |
|
| 2002 |
Dunaief JL, King A, Esumi N, Eagen M, Dentchev T, Sung CH, Chen S, Zack DJ. Protein Phosphatase 1 binds strongly to the retinoblastoma protein but not to p107 or p130 in vitro and in vivo. Current Eye Research. 24: 392-6. PMID 12434308 DOI: 10.1076/Ceyr.24.5.392.8524 |
0.707 |
|
| 2002 |
Wang X, Xu S, Rivolta C, Li LY, Peng GH, Swain PK, Sung CH, Swaroop A, Berson EL, Dryja TP, Chen S. Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function. The Journal of Biological Chemistry. 277: 43288-300. PMID 12215455 DOI: 10.1074/Jbc.M207952200 |
0.621 |
|
| 2002 |
Chen S, Wang QL, Xu S, Liu I, Li LY, Wang Y, Zack DJ. Functional analysis of cone-rod homeobox (CRX) mutations associated with retinal dystrophy. Human Molecular Genetics. 11: 873-84. PMID 11971869 DOI: 10.1093/Hmg/11.8.873 |
0.779 |
|
| 2001 |
La Spada AR, Fu YH, Sopher BL, Libby RT, Wang X, Li LY, Einum DD, Huang J, Possin DE, Smith AC, Martinez RA, Koszdin KL, Treuting PM, Ware CB, Hurley JB, ... ... Chen S, et al. Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. Neuron. 31: 913-27. PMID 11580893 DOI: 10.1016/S0896-6273(01)00422-6 |
0.527 |
|
| 2000 |
Chau KY, Chen S, Zack DJ, Ono SJ. Functional domains of the cone-rod homeobox (CRX) transcription factor. The Journal of Biological Chemistry. 275: 37264-70. PMID 10984472 DOI: 10.1074/Jbc.M002763200 |
0.698 |
|
| 2000 |
Mitton KP, Swain PK, Chen S, Xu S, Zack DJ, Swaroop A. The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation. The Journal of Biological Chemistry. 275: 29794-9. PMID 10887186 DOI: 10.1074/Jbc.M003658200 |
0.659 |
|
| 2000 |
Chen S, Zack DJ. Cloning and characterization of retinal transcription factors, using target site-based methodology. Methods in Enzymology. 316: 590-610. PMID 10800704 DOI: 10.1016/S0076-6879(00)16752-7 |
0.7 |
|
| 1999 |
Fei Y, Matragoon S, Smith SB, Overbeek PA, Chen S, Zack DJ, Liou GI. Functional dissection of the promoter of the interphotoreceptor retinoid-binding protein gene: the cone-rod-homeobox element is essential for photoreceptor-specific expression in vivo. Journal of Biochemistry. 125: 1189-99. PMID 10348924 DOI: 10.1093/Oxfordjournals.Jbchem.A022403 |
0.715 |
|
| 1999 |
Swaroop A, Wang QL, Wu W, Cook J, Coats C, Xu S, Chen S, Zack DJ, Sieving PA. Leber congenital amaurosis caused by a homozygous mutation (R90W) in the homeodomain of the retinal transcription factor CRX: direct evidence for the involvement of CRX in the development of photoreceptor function. Human Molecular Genetics. 8: 299-305. PMID 9931337 DOI: 10.1093/Hmg/8.2.299 |
0.725 |
|
| 1998 |
Freund CL, Wang QL, Chen S, Muskat BL, Wiles CD, Sheffield VC, Jacobson SG, McInnes RR, Zack DJ, Stone EM. De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis. Nature Genetics. 18: 311-2. PMID 9537410 DOI: 10.1038/Ng0498-311 |
0.562 |
|
| 1997 |
Swain PK, Chen S, Wang QL, Affatigato LM, Coats CL, Brady KD, Fishman GA, Jacobson SG, Swaroop A, Stone E, Sieving PA, Zack DJ. Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration. Neuron. 19: 1329-36. PMID 9427255 DOI: 10.1016/S0896-6273(00)80423-7 |
0.668 |
|
| 1997 |
Chen S, Wang QL, Nie Z, Sun H, Lennon G, Copeland NG, Gilbert DJ, Jenkins NA, Zack DJ. Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron. 19: 1017-30. PMID 9390516 DOI: 10.1016/S0896-6273(00)80394-3 |
0.646 |
|
| 1996 |
Kumar R, Chen S, Scheurer D, Wang QL, Duh E, Sung CH, Rehemtulla A, Swaroop A, Adler R, Zack DJ. The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures. The Journal of Biological Chemistry. 271: 29612-8. PMID 8939891 DOI: 10.1074/Jbc.271.47.29612 |
0.765 |
|
| 1996 |
Chen S, Zack DJ. Ret 4, a positive acting rhodopsin regulatory element identified using a bovine retina in vitro transcription system. The Journal of Biological Chemistry. 271: 28549-57. PMID 8910484 DOI: 10.1074/Jbc.271.45.28549 |
0.684 |
|
| 1996 |
Nie Z, Chen S, Kumar R, Zack DJ. RER, an evolutionarily conserved sequence upstream of the rhodopsin gene, has enhancer activity. The Journal of Biological Chemistry. 271: 2667-75. PMID 8576239 DOI: 10.1074/Jbc.271.5.2667 |
0.737 |
|
| 1990 |
Finley RL, Chen S, Ma J, Byrne P, West RW. Opposing regulatory functions of positive and negative elements in UASG control transcription of the yeast GAL genes. Molecular and Cellular Biology. 10: 5663-70. PMID 2122231 DOI: 10.1128/MCB.10.11.5663 |
0.319 |
|
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