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Samuel H. Sternberg, Ph.D. - Publications

Affiliations: 
2018- Chemistry Columbia University, New York, NY 
Area:
molecular structure of RNA enzymes (ribozymes)
Website:
https://www.sternberglab.org/sam-sternberg
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51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Gelsinger DR, Vo PLH, Klompe SE, Ronda C, Wang HH, Sternberg SH. Bacterial genome engineering using CRISPR-associated transposases. Nature Protocols. PMID 38216671 DOI: 10.1038/s41596-023-00927-3  0.854
2023 Wiegand T, Hoffmann FT, Walker MWG, Tang S, Richard E, Le HC, Meers C, Sternberg SH. Emergence of RNA-guided transcription factors via domestication of transposon-encoded TnpB nucleases. Biorxiv : the Preprint Server For Biology. PMID 38076855 DOI: 10.1101/2023.11.30.569447  0.503
2023 Žedaveinytė R, Meers C, Le HC, Mortman EE, Tang S, Lampe GD, Pesari SR, Gelsinger DR, Wiegand T, Sternberg SH. Antagonistic conflict between transposon-encoded introns and guide RNAs. Biorxiv : the Preprint Server For Biology. PMID 38045383 DOI: 10.1101/2023.11.20.567912  0.452
2023 George JT, Acree C, Park JU, Kong M, Wiegand T, Pignot YL, Kellogg EH, Greene EC, Sternberg SH. Mechanism of target site selection by type V-K CRISPR-associated transposases. Science (New York, N.Y.). 382: eadj8543. PMID 37972161 DOI: 10.1126/science.adj8543  0.401
2023 Tang S, Sternberg SH. Genome editing with retroelements. Science (New York, N.Y.). 382: 370-371. PMID 37883564 DOI: 10.1126/science.adi3183  0.494
2023 Meers C, Le HC, Pesari SR, Hoffmann FT, Walker MWG, Gezelle J, Tang S, Sternberg SH. Transposon-encoded nucleases use guide RNAs to promote their selfish spread. Nature. 622: 863-871. PMID 37758954 DOI: 10.1038/s41586-023-06597-1  0.504
2023 George JT, Acree C, Park JU, Kong M, Wiegand T, Pignot YL, Kellogg EH, Greene EC, Sternberg SH. Mechanism of target site selection by type V-K CRISPR-associated transposases. Biorxiv : the Preprint Server For Biology. PMID 37503092 DOI: 10.1101/2023.07.14.548620  0.503
2023 Walker MWG, Klompe SE, Zhang DJ, Sternberg SH. Novel molecular requirements for CRISPR RNA-guided transposition. Nucleic Acids Research. PMID 37078593 DOI: 10.1093/nar/gkad270  0.868
2023 Meers C, Le H, Pesari SR, Hoffmann FT, Walker MWG, Gezelle J, Sternberg SH. Transposon-encoded nucleases use guide RNAs to selfishly bias their inheritance. Biorxiv : the Preprint Server For Biology. PMID 36993599 DOI: 10.1101/2023.03.14.532601  0.77
2023 Gelsinger DR, Vo PLH, Klompe SE, Ronda C, Wang H, Sternberg SH. Bacterial genome engineering using CRISPR RNA-guided transposases. Biorxiv : the Preprint Server For Biology. PMID 36993567 DOI: 10.1101/2023.03.18.533263  0.854
2023 Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH. Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases. Biorxiv : the Preprint Server For Biology. PMID 36993517 DOI: 10.1101/2023.03.17.533036  0.789
2023 Lampe GD, King RT, Halpin-Healy TS, Klompe SE, Hogan MI, Vo PLH, Tang S, Chavez A, Sternberg SH. Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases. Nature Biotechnology. PMID 36991112 DOI: 10.1038/s41587-023-01748-1  0.782
2023 Walker MWG, Klompe SE, Zhang DJ, Sternberg SH. Transposon mutagenesis libraries reveal novel molecular requirements during CRISPR RNA-guided DNA integration. Biorxiv : the Preprint Server For Biology. PMID 36711804 DOI: 10.1101/2023.01.19.524723  0.868
2022 Nemudryi A, Nemudraia A, Wiegand T, Sternberg SH, Wiedenheft B. A viral "codebreaker" intercepts a host alarm. Cell Host & Microbe. 30: 1647-1648. PMID 36521436 DOI: 10.1016/j.chom.2022.11.005  0.587
2022 Lampe GD, Sternberg SH. Novel recombinases for large DNA insertions. Nature Biotechnology. PMID 36424492 DOI: 10.1038/s41587-022-01600-y  0.401
2022 Hoffmann FT, Kim M, Beh LY, Wang J, Vo PLH, Gelsinger DR, George JT, Acree C, Mohabir JT, Fernández IS, Sternberg SH. Selective TnsC recruitment enhances the fidelity of RNA-guided transposition. Nature. PMID 36002573 DOI: 10.1038/s41586-022-05059-4  0.803
2022 Klompe SE, Jaber N, Beh LY, Mohabir JT, Bernheim A, Sternberg SH. Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons. Molecular Cell. PMID 35051352 DOI: 10.1016/j.molcel.2021.12.021  0.864
2021 Vo PLH, Acree C, Smith ML, Sternberg SH. Unbiased profiling of CRISPR RNA-guided transposition products by long-read sequencing. Mobile Dna. 12: 13. PMID 34103093 DOI: 10.1186/s13100-021-00242-2  0.576
2020 Vo PLH, Ronda C, Klompe SE, Chen EE, Acree C, Wang HH, Sternberg SH. CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering. Nature Biotechnology. PMID 33230293 DOI: 10.1038/s41587-020-00745-y  0.865
2020 Halpin-Healy TS, Klompe SE, Sternberg SH, Fernández IS. Publisher Correction: Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system. Nature. PMID 32843756 DOI: 10.1038/S41586-020-2662-5  0.784
2019 Halpin-Healy TS, Klompe SE, Sternberg SH, Fernández IS. Structural basis of DNA targeting by a transposon-encoded CRISPR-Cas system. Nature. PMID 31853065 DOI: 10.1038/S41586-019-1849-0  0.843
2019 Cameron P, Coons MM, Klompe SE, Lied AM, Smith SC, Vidal B, Donohoue PD, Rotstein T, Kohrs BW, Nyer DB, Kennedy R, Banh LM, Williams C, Toh MS, Irby MJ, ... ... Sternberg SH, et al. Harnessing type I CRISPR-Cas systems for genome engineering in human cells. Nature Biotechnology. PMID 31740839 DOI: 10.1038/S41587-019-0310-0  0.849
2019 Klompe SE, Vo PLH, Halpin-Healy TS, Sternberg SH. Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration. Nature. PMID 31189177 DOI: 10.1038/S41586-019-1323-Z  0.844
2018 Klompe SE, Sternberg SH. Harnessing "A Billion Years of Experimentation": The Ongoing Exploration and Exploitation of CRISPR-Cas Immune Systems. The Crispr Journal. 1: 141-158. PMID 31021200 DOI: 10.1089/crispr.2018.0012  0.812
2017 Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. Nature. PMID 28931002 DOI: 10.1038/nature24268  0.661
2017 Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9. Science Advances. 3: eaao0027. PMID 28808686 DOI: 10.1126/Sciadv.Aao0027  0.718
2017 Jackson RN, van Erp PB, Sternberg SH, Wiedenheft B. Conformational regulation of CRISPR-associated nucleases. Current Opinion in Microbiology. 37: 110-119. PMID 28646675 DOI: 10.1016/J.Mib.2017.05.010  0.723
2017 Boyle EA, Andreasson JOL, Chircus LM, Sternberg SH, Wu MJ, Guegler CK, Doudna JA, Greenleaf WJ. High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding. Proceedings of the National Academy of Sciences of the United States of America. PMID 28495970 DOI: 10.1073/Pnas.1700557114  0.702
2017 Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. Conformational Dynamics of Cas9 during DNA Binding Biophysical Journal. 112: 71a. DOI: 10.1016/J.Bpj.2016.11.429  0.721
2016 Singh D, Sternberg SH, Fei J, Doudna JA, Ha T. Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9. Nature Communications. 7: 12778. PMID 27624851 DOI: 10.1038/Ncomms12778  0.751
2016 Sternberg SH, Richter H, Charpentier E, Qimron U. Adaptation in CRISPR-Cas Systems. Molecular Cell. PMID 26949040 DOI: 10.1016/J.Molcel.2016.01.030  0.423
2015 Sternberg SH, LaFrance B, Kaplan M, Doudna JA. Conformational control of DNA target cleavage by CRISPR-Cas9. Nature. 527: 110-3. PMID 26524520 DOI: 10.1038/Nature15544  0.729
2015 Redding S, Sternberg SH, Marshall M, Gibb B, Bhat P, Guegler CK, Wiedenheft B, Doudna JA, Greene EC. Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System. Cell. 163: 854-65. PMID 26522594 DOI: 10.1016/J.Cell.2015.10.003  0.832
2015 Sternberg SH, Doudna JA. Expanding the Biologist's Toolkit with CRISPR-Cas9. Molecular Cell. 58: 568-74. PMID 26000842 DOI: 10.1016/J.Molcel.2015.02.032  0.669
2015 Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, ... Sternberg SH, et al. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science (New York, N.Y.). 348: 36-8. PMID 25791083 DOI: 10.1126/Science.Aab1028  0.578
2015 Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna JA. Rational design of a split-Cas9 enzyme complex. Proceedings of the National Academy of Sciences of the United States of America. 112: 2984-9. PMID 25713377 DOI: 10.1073/Pnas.1501698112  0.874
2015 Singh D, Sternberg SH, Fei J, Doudna JA, Ha T. Real-Time Observation of DNA Recognition by the RNA-Guided Endonuclease Cas9 using Single-Molecule FRET Biophysical Journal. 108: 26a. DOI: 10.1016/J.Bpj.2014.11.169  0.775
2014 O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature. 516: 263-6. PMID 25274302 DOI: 10.1038/Nature13769  0.852
2014 Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proceedings of the National Academy of Sciences of the United States of America. 111: 6618-23. PMID 24748111 DOI: 10.1073/Pnas.1405079111  0.792
2014 Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science (New York, N.Y.). 343: 1247997. PMID 24505130 DOI: 10.1126/Science.1247997  0.804
2014 Sternberg SH, Redding S, Jinek M, Greene EC, Doudna JA. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature. 507: 62-7. PMID 24476820 DOI: 10.1038/Nature13011  0.746
2014 Redding S, Sternberg SH, Bhat P, Guegler CK, Hochstrasser ML, Wiedenheft B, Doudna JA, Greene EC. Targeting and Degradation of Viral DNA by the CRISPR-Cas System of Escherichia Coli Biophysical Journal. 106: 430a. DOI: 10.1016/J.Bpj.2013.11.2421  0.844
2013 Sternberg SH, Redding S, Bhat P, Jinek M, Wiedenheft B, Doudna JA, Greene EC. Single-Molecule Observation of Viral DNA Targeting by CRISPR/Cas Immune Systems Biophysical Journal. 104: 198a. DOI: 10.1016/J.Bpj.2012.11.1120  0.838
2012 Haurwitz RE, Sternberg SH, Doudna JA. Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA. The Embo Journal. 31: 2824-32. PMID 22522703 DOI: 10.1038/Emboj.2012.107  0.82
2012 Sternberg SH, Haurwitz RE, Doudna JA. Mechanism of substrate selection by a highly specific CRISPR endoribonuclease. Rna (New York, N.Y.). 18: 661-72. PMID 22345129 DOI: 10.1261/Rna.030882.111  0.822
2012 Wiedenheft B, Sternberg SH, Doudna JA. RNA-guided genetic silencing systems in bacteria and archaea. Nature. 482: 331-8. PMID 22337052 DOI: 10.1038/Nature10886  0.762
2012 Jensen MK, Fei J, Richard AC, Sternberg SH, Gonzalez RL. The Magnesium Dependence of Ribosome and tRNA Dynamics in Single Pre-Translocation Ribosomal Complexes Biophysical Journal. 102: 69a. DOI: 10.1016/J.Bpj.2011.11.403  0.394
2010 Chakravarthy S, Sternberg SH, Kellenberger CA, Doudna JA. Substrate-specific kinetics of Dicer-catalyzed RNA processing. Journal of Molecular Biology. 404: 392-402. PMID 20932845 DOI: 10.1016/J.Jmb.2010.09.030  0.694
2010 Fei J, Wang J, Sternberg SH, MacDougall DD, Elvekrog MM, Pulukkunat DK, Englander MT, Gonzalez RL. A highly purified, fluorescently labeled in vitro translation system for single-molecule studies of protein synthesis. Methods in Enzymology. 472: 221-59. PMID 20580967 DOI: 10.1016/S0076-6879(10)72008-5  0.332
2009 Sternberg SH, Fei J, Prywes N, McGrath KA, Gonzalez RL. Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling. Nature Structural & Molecular Biology. 16: 861-8. PMID 19597483 DOI: 10.1038/Nsmb.1622  0.329
2009 Gonzalez RL, Fei J, Sternberg SH. Coupling Of Ribosome And tRNA Dynamics During Translation Biophysical Journal. 96: 10a. DOI: 10.1016/J.Bpj.2008.12.947  0.337
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