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Richard Y-C Huang, Ph.D. - Publications

Affiliations: 
2012 Chemistry Washington University, Saint Louis, St. Louis, MO 
Area:
Mass spectrometry for protein biochemistry and biophysics
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Liu XR, Huang RY, Zhao F, Chen G, Tao L. Advances in mass spectrometry-based epitope mapping of protein therapeutics. Journal of Pharmaceutical and Biomedical Analysis. 215: 114754. PMID 35427962 DOI: 10.1016/j.jpba.2022.114754  0.364
2021 Li BX, Kim DK, Bloom S, Huang RY, Qiao JX, Ewing WR, Oblinsky DG, Scholes GD, MacMillan DWC. Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation. Nature Chemistry. PMID 34183819 DOI: 10.1038/s41557-021-00733-y  0.302
2021 Song JH, Wagner ND, Yan J, Li J, Huang RY, Balog AJ, Newitt JA, Chen G, Gross ML. Native mass spectrometry and gas-phase fragmentation provide rapid and in-depth topological characterization of a PROTAC ternary complex. Cell Chemical Biology. PMID 34081921 DOI: 10.1016/j.chembiol.2021.05.005  0.61
2021 Huang RY, Wang Y, Jhatakia AD, Deng AX, Bee C, Deshpande S, Rangan VS, Bezman N, Gudmundsson O, Chen G. Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies. Journal of the American Society For Mass Spectrometry. PMID 33415981 DOI: 10.1021/jasms.0c00399  0.307
2020 Deyanova EG, Huang RY, Madia PA, Nandi P, Gudmundsson O, Chen G. Rapid Fingerprinting of a Highly Glycosylated Fusion Protein by Microfluidic Chip-based Capillary Electrophoresis-Mass Spectrometry. Electrophoresis. PMID 32885501 DOI: 10.1002/elps.202000132  0.332
2020 Huang RY, Wang F, Wheeler M, Wang Y, Langish R, Chau B, Dong J, Morishige W, Bezman N, Strop P, Rajpal A, Gudmundsson O, Chen G. An Integrated Approach for Characterizing Bispecific Antibody/Antigens Complexes and Mapping Binding Epitopes with SEC/MALS, Native Mass Spectrometry and Protein Footprinting. Analytical Chemistry. PMID 32639723 DOI: 10.1021/acs.analchem.0c01876  0.342
2020 Zhang MM, Huang RY, Beno BR, Deyanova EG, Li J, Chen G, Gross ML. Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-based Hydrogen/Deuterium Exchange, Cross-linking, and Molecular Docking. Analytical Chemistry. PMID 32441507 DOI: 10.1021/Acs.Analchem.0C01291  0.41
2019 Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable J, Steckler C, et al. Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Centroid Data Measured between 3.6 °C and 25.4 °C for the Fab Fragment of NISTmAb. Journal of Research of the National Institute of Standards and Technology. 124: 1-7. PMID 34877153 DOI: 10.6028/jres.124.009  0.597
2019 Li KS, Schaper Bergman ET, Beno BR, Huang RY, Deyanova E, Chen G, Gross ML. Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor. Journal of the American Society For Mass Spectrometry. PMID 31720974 DOI: 10.1007/S13361-019-02316-1  0.5
2019 Zhang MM, Beno BR, Huang RY, Adhikari J, Deyanova EG, Li J, Chen G, Gross ML. An Integrated Approach for Determining a Protein-Protein Binding Interface in Solution and an Evaluation of HDX Kinetics for Adjudicating Candidate Docking Models. Analytical Chemistry. PMID 31710208 DOI: 10.1021/Acs.Analchem.9B03879  0.482
2019 Hudgens JW, Gallagher ES, Karageorgos I, Anderson KW, Filliben JJ, Huang RY, Chen G, Bou-Assaf GM, Espada A, Chalmers MJ, Harguindey E, Zhang HM, Walters BT, Zhang J, Venable JD, et al. Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry Measurements of the Fab fragment of NISTmAb. Analytical Chemistry. PMID 31045344 DOI: 10.1021/Acs.Analchem.9B01100  0.628
2018 Huang RY, O'Neil SR, Lipovšek D, Chen G. Conformational Assessment of Adnectin and Adnectin-Drug Conjugate by Hydrogen/Deuterium Exchange Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 29736601 DOI: 10.1007/s13361-018-1966-2  0.347
2017 Li KS, Chen G, Mo J, Huang RY, Deyanova EG, Beno BR, O'Neil S, Tymiak AA, Gross ML. Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics. Analytical Chemistry. PMID 28621526 DOI: 10.1021/Acs.Analchem.7B01748  0.496
2017 Li J, Wei H, Krystek SR, Bond D, Brender TM, Cohen D, Feiner J, Hamacher N, Harshman J, Huang RY, Julien SH, Lin Z, Moore K, Mueller L, Noriega C, et al. Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis. Analytical Chemistry. PMID 28193005 DOI: 10.1021/Acs.Analchem.6B03058  0.432
2016 Huang RY, Iacob RE, Krystek SR, Jin M, Wei H, Tao L, Das TK, Tymiak AA, Engen JR, Chen G. Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 27527097 DOI: 10.1007/S13361-016-1452-7  0.344
2016 Mehl JT, Sleczka BG, Ciccimaro EF, Kozhich AT, Gilbertson DG, Vuppugalla R, Huang CS, Stevens B, Mo J, Deyanova EG, Wang Y, Huang RY, Chen G, Olah TV. Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS. Bioanalysis. PMID 27397670 DOI: 10.4155/Bio-2016-0035  0.306
2016 Yu D, Song Y, Huang RY, Swanson RK, Tan Z, Schutsky E, Lewandowski A, Chen G, Li ZJ. Molecular perspective of antibody aggregates and their adsorption on Protein A resin. Journal of Chromatography. A. PMID 27344283 DOI: 10.1016/j.chroma.2016.06.031  0.33
2014 Yan Y, Chen G, Wei H, Huang RY, Mo J, Rempel DL, Tymiak AA, Gross ML. Fast photochemical oxidation of proteins (FPOP) maps the epitope of EGFR binding to adnectin. Journal of the American Society For Mass Spectrometry. 25: 2084-92. PMID 25267085 DOI: 10.1007/S13361-014-0993-X  0.598
2014 Huang RY, Chen G. Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry. Analytical and Bioanalytical Chemistry. 406: 6541-58. PMID 24948090 DOI: 10.1007/s00216-014-7924-3  0.372
2013 Liu H, Chen J, Huang RY, Weisz D, Gross ML, Pakrasi HB. Mass spectrometry-based footprinting reveals structural dynamics of loop E of the chlorophyll-binding protein CP43 during photosystem II assembly in the cyanobacterium Synechocystis 6803. The Journal of Biological Chemistry. 288: 14212-20. PMID 23546881 DOI: 10.1074/Jbc.M113.467613  0.554
2012 Zhang H, Wen J, Huang RY, Blankenship RE, Gross ML. Mass spectrometry-based carboxyl footprinting of proteins: method evaluation. International Journal of Mass Spectrometry. 312: 78-86. PMID 22408386 DOI: 10.1016/J.Ijms.2011.07.015  0.574
2012 Huang RY, Wen J, Blankenship RE, Gross ML. Hydrogen-deuterium exchange mass spectrometry reveals the interaction of Fenna-Matthews-Olson protein and chlorosome CsmA protein. Biochemistry. 51: 187-93. PMID 22142245 DOI: 10.1021/Bi201620Y  0.548
2011 Liu H, Huang RY, Chen J, Gross ML, Pakrasi HB. Psb27, a transiently associated protein, binds to the chlorophyll binding protein CP43 in photosystem II assembly intermediates. Proceedings of the National Academy of Sciences of the United States of America. 108: 18536-41. PMID 22031695 DOI: 10.1073/Pnas.1111597108  0.572
2011 Huang RY, Garai K, Frieden C, Gross ML. Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization. Biochemistry. 50: 9273-82. PMID 21899263 DOI: 10.1021/Bi2010027  0.473
2011 Sperry JB, Huang RY, Zhu MM, Rempel DL, Gross ML. Hydrophobic Peptides Affect Binding of Calmodulin and Ca as Explored by H/D Amide Exchange and Mass Spectrometry. International Journal of Mass Spectrometry. 302: 85-92. PMID 21765646 DOI: 10.1016/J.Ijms.2010.08.013  0.652
2011 Huang RY, Rempel DL, Gross ML. HD exchange and PLIMSTEX determine the affinities and order of binding of Ca2+ with troponin C. Biochemistry. 50: 5426-35. PMID 21574565 DOI: 10.1021/Bi200377C  0.434
2011 Huang RY, Laing JG, Kanter EM, Berthoud VM, Bao M, Rohrs HW, Townsend RR, Yamada KA. Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. Journal of Proteome Research. 10: 1098-109. PMID 21158428 DOI: 10.1021/Pr1008702  0.369
2010 Zhang H, Huang RY, Jalili PR, Irungu JW, Nicol GR, Ray KB, Rohrs HW, Gross ML. Improved mass spectrometric characterization of protein glycosylation reveals unusual glycosylation of maize-derived bovine trypsin. Analytical Chemistry. 82: 10095-101. PMID 21077632 DOI: 10.1021/Ac1020722  0.501
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