| Year |
Citation |
Score |
| 2023 |
Davoodi S, Daryaee F, Iuliano JN, Tolentino Collado J, He Y, Pollard AC, Gil AA, Aramini JM, Tonge PJ. Evaluating the Impact of the Tyr158 p on the Mechanism and Inhibition of InhA, the Enoyl-ACP Reductase from . Biochemistry. PMID 37270808 DOI: 10.1021/acs.biochem.2c00606 |
0.362 |
|
| 2022 |
Tolentino Collado J, Iuliano JN, Pirisi K, Jewlikar S, Adamczyk K, Greetham GM, Towrie M, Tame JRH, Meech SR, Tonge PJ, Lukacs A. Unraveling the Photoactivation Mechanism of a Light-Activated Adenylyl Cyclase Using Ultrafast Spectroscopy Coupled with Unnatural Amino Acid Mutagenesis. Acs Chemical Biology. PMID 36038143 DOI: 10.1021/acschembio.2c00575 |
0.305 |
|
| 2021 |
Fernández de Luco J, Recio-Balsells AI, Ghiano DG, Bortolotti A, Belardinelli JM, Liu N, Hoffmann P, Lherbet C, Tonge PJ, Tekwani B, Morbidoni HR, Labadie GR. Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents. Rsc Medicinal Chemistry. 12: 120-128. PMID 34046604 DOI: 10.1039/d0md00291g |
0.653 |
|
| 2021 |
Eltschkner S, Kehrein J, Le TA, Davoodi S, Merget B, Basak S, Weinrich JD, Schiebel J, Tonge PJ, Engels B, Sotriffer C, Kisker C. A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure. Acs Infectious Diseases. PMID 33710875 DOI: 10.1021/acsinfecdis.0c00437 |
0.324 |
|
| 2020 |
Chitrakar I, Iuliano JN, He Y, Woroniecka H, Tolentino Collado J, Wint J, Walker SG, Tonge PJ, French JB. Structural basis for the regulation of biofilm formation and iron uptake in A. baumannii by the blue-light using photoreceptor, BlsA. Acs Infectious Diseases. PMID 32926768 DOI: 10.1021/Acsinfecdis.0C00156 |
0.356 |
|
| 2020 |
Iuliano JN, Tolentino Collado J, Gil AA, Ravindran PT, Lukacs A, Shin S, Woroniecka HA, Adamczyk K, Aramini JM, Edupuganti UR, Hall CR, Greetham GM, Sazanovich IV, Clark IP, Daryaee T, ... ... Tonge PJ, et al. Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix. Acs Chemical Biology. PMID 32880430 DOI: 10.1021/Acschembio.0C00543 |
0.342 |
|
| 2020 |
Iuliano JN, Hall CR, Green D, Jones GA, Lukacs A, Illarionov B, Bacher A, Fischer M, French JB, Tonge PJ, Meech SR. Excited State Vibrations of Isotopically Labeled FMN Free and Bound to a Light-Oxygen-Voltage (LOV) Protein. The Journal of Physical Chemistry. B. PMID 32786715 DOI: 10.1021/Acs.Jpcb.0C04943 |
0.357 |
|
| 2020 |
Karadi K, Kapetanaki SM, Raics K, Pecsi I, Kapronczai R, Fekete Z, Iuliano JN, Collado JT, Gil AA, Orban J, Nyitrai M, Greetham GM, Vos MH, Tonge PJ, Meech SR, et al. Functional dynamics of a single tryptophan residue in a BLUF protein revealed by fluorescence spectroscopy. Scientific Reports. 10: 2061. PMID 32029866 DOI: 10.1038/S41598-020-59073-5 |
0.405 |
|
| 2019 |
Hall CR, Tolentino Collado J, Iuliano JN, Adamczyk K, Lukacs A, Greetham GM, Sazanovich IV, Tonge PJ, Meech SR. Site Specific Protein Dynamics Probed by Ultrafast Infrared Spectroscopy of a Noncanonical Amino Acid. The Journal of Physical Chemistry. B. PMID 31596584 DOI: 10.1021/Acs.Jpcb.9B09425 |
0.389 |
|
| 2019 |
Iuliano JN, French JB, Tonge PJ. Vibrational spectroscopy of flavoproteins. Methods in Enzymology. 620: 189-214. PMID 31072487 DOI: 10.1016/Bs.Mie.2019.03.011 |
0.331 |
|
| 2019 |
Si Y, Basak S, Li Y, Merino J, Iuliano JN, Walker SG, Tonge PJ. Antibacterial Activity and Mode of Action of a Sulfonamide-Based Class of Oxaborole Leucyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. PMID 31007018 DOI: 10.1021/Acsinfecdis.9B00071 |
0.357 |
|
| 2019 |
Evans CE, Si Y, Matarlo JS, Yin Y, French JB, Tonge PJ, Tan DS. Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE. Biochemistry. PMID 30912442 DOI: 10.1021/Acs.Biochem.9B00003 |
0.408 |
|
| 2019 |
Tonge PJ. Quantifying the Interactions between Biomolecules: Guidelines for Assay Design and Data Analysis. Acs Infectious Diseases. PMID 30860805 DOI: 10.1021/Acsinfecdis.9B00012 |
0.32 |
|
| 2018 |
Lu H, Iuliano JN, Tonge PJ. Structure-kinetic relationships that control the residence time of drug-target complexes: insights from molecular structure and dynamics. Current Opinion in Chemical Biology. 44: 101-109. PMID 29986213 DOI: 10.1016/J.Cbpa.2018.06.002 |
0.479 |
|
| 2018 |
Laptenok SP, Gil AA, Hall CR, Lukacs A, Iuliano JN, Jones GA, Greetham GM, Donaldson P, Miyawaki A, Tonge PJ, Meech SR. Infrared spectroscopy reveals multi-step multi-timescale photoactivation in the photoconvertible protein archetype dronpa. Nature Chemistry. PMID 29892029 DOI: 10.1038/S41557-018-0073-0 |
0.383 |
|
| 2017 |
Iuliano JN, Gil AA, Laptenok SP, Hall CR, Tolentino Collado J, Lukacs A, Hag Ahmed SA, Abyad J, Daryaee T, Greetham GM, Sazanovich IV, Illarionov B, Bacher A, Fischer M, Towrie M, ... ... Tonge PJ, et al. Variation in LOV Photoreceptor Activation Dynamics Probed by Time Resolved Infrared Spectroscopy. Biochemistry. PMID 29239168 DOI: 10.1021/Acs.Biochem.7B01040 |
0.333 |
|
| 2017 |
Gil AA, Laptenok SP, Iuliano JN, Lukacs A, Verma A, Hall CR, Yoon E, Brust R, Greetham GM, Towrie M, French JB, Meech SR, Tonge PJ. Photoactivation of the BLUF protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues. Journal of the American Chemical Society. PMID 28876066 DOI: 10.1021/Jacs.7B07849 |
0.643 |
|
| 2017 |
Tonge PJ. Drug-Target Kinetics in Drug Discovery. Acs Chemical Neuroscience. PMID 28640596 DOI: 10.1021/Acschemneuro.7B00185 |
0.324 |
|
| 2017 |
Daryaee F, Zhang Z, Gogarty KR, Li Y, Merino J, Fisher SL, Tonge PJ. A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy. Chemical Science. 8: 3434-3443. PMID 28507715 DOI: 10.1039/C6Sc03306G |
0.306 |
|
| 2017 |
Neckles CM, Eltschkner S, Cummings JE, Hirschbeck M, Daryaee F, Bommineni GR, Zhang Z, Spagnuolo LA, Yu W, Davoodi S, Slayden RA, Kisker C, Tonge PJ. Rational Optimization of Diphenyl Ether Binding Kinetics to the Enoyl-ACP Reductase FabI1 from Burkholderia pseudomallei. Biochemistry. PMID 28225601 DOI: 10.1021/Acs.Biochem.6B01048 |
0.421 |
|
| 2017 |
Spagnuolo LA, Eltschkner S, Yu W, Daryaee F, Davoodi S, Knudson SE, Allen EK, Merino J, Pschibul A, Moree B, Thivalapill N, Truglio JJ, Salafsky J, Slayden RA, Kisker C, ... Tonge PJ, et al. Evaluating the contribution of transition state destabilization to changes in the residence time of triazole-based InhA inhibitors. Journal of the American Chemical Society. PMID 28151657 DOI: 10.1021/Jacs.6B11148 |
0.412 |
|
| 2017 |
Gil AA, Laptenok SP, French JB, Iuliano JN, Lukacs A, Hall CR, Sazanovich IV, Greetham GM, Bacher A, Illarionov B, Fischer M, Tonge PJ, Meech SR. Femtosecond To Millisecond Dynamics Of Light Induced Allostery In The Avena Sativa Lov Domain. The Journal of Physical Chemistry. B. PMID 28068090 DOI: 10.1021/Acs.Jpcb.7B00088 |
0.405 |
|
| 2017 |
Hall CR, Heisler IA, Jones GA, Frost JE, Gil AA, Tonge PJ, Meech SR. Femtosecond stimulated Raman study of the photoactive flavoprotein AppABLUF Chemical Physics Letters. 683: 365-369. DOI: 10.1016/J.Cplett.2017.03.030 |
0.374 |
|
| 2016 |
Evans CE, Matarlo JS, Tonge PJ, Tan DS. Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics. Organic Letters. 18: 6384-6387. PMID 27978658 DOI: 10.1021/Acs.Orglett.6B03272 |
0.364 |
|
| 2016 |
Knudson SE, Cummings JE, Bommineni GR, Pan P, Tonge PJ, Slayden RA. Formulation studies of InhA inhibitors and combination therapy to improve efficacy against Mycobacterium tuberculosis. Tuberculosis (Edinburgh, Scotland). 101: 8-14. PMID 27865404 DOI: 10.1016/J.Tube.2016.07.016 |
0.516 |
|
| 2016 |
Ghiano DG, de la Iglesia A, Liu N, Tonge PJ, Morbidoni HR, Labadie GR. Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives. European Journal of Medicinal Chemistry. 125: 842-852. PMID 27750201 DOI: 10.1016/J.Ejmech.2016.09.086 |
0.676 |
|
| 2016 |
Daryaee F, Chang A, Schiebel J, Lu Y, Zhang Z, Kapilashrami K, Walker SG, Kisker C, Sotriffer CA, Fisher SL, Tonge PJ. Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase. Chemical Science. 7: 5945-5954. PMID 27547299 DOI: 10.1039/C6Sc01000H |
0.768 |
|
| 2016 |
Matarlo JS, Lu Y, Daryaee F, Daryaee T, Ruzsicska B, Walker SG, Tonge PJ. A Methyl 4-Oxo-4-phenylbut-2-enoate with in Vivo Activity against MRSA that Inhibits MenB in the Bacterial Menaquinone Biosynthesis Pathway. Acs Infectious Diseases. 2: 329-340. PMID 27294200 DOI: 10.1021/Acsinfecdis.6B00023 |
0.338 |
|
| 2016 |
Bommineni GR, Kapilashrami K, Cummings JE, Lu Y, Knudson SE, Gu C, Walker SG, Slayden RA, Tonge PJ. Thiolactomycin-based inhibitors of bacterial β-ketoacyl-ACP synthases with in vivo activity. Journal of Medicinal Chemistry. PMID 27187871 DOI: 10.1021/Acs.Jmedchem.6B00236 |
0.775 |
|
| 2016 |
Neckles CM, Pschibul A, Lai CE, Hirschbeck M, Kuper J, Davoodi S, Zou J, Liu N, Pan P, Shah S, Daryaee F, Bommineni GR, Lai C, Simmerling C, Kisker C, ... Tonge PJ, et al. Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase FabV. Biochemistry. PMID 27136302 DOI: 10.1021/Acs.Biochem.5B01301 |
0.761 |
|
| 2015 |
Gil AA, Haigney AL, Laptenok SP, Brust RJ, Lukacs A, Iuliano J, Jeng J, Melief E, Zhao RK, Yoon E, Clark IP, Towrie M, Greetham GM, Ng A, Truglio JJ, ... ... Tonge PJ, et al. The Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: The Effect of the Y21 pKa on the Forward and Reverse Ground State Reactions. Journal of the American Chemical Society. PMID 26708408 DOI: 10.1021/Jacs.5B11115 |
0.792 |
|
| 2015 |
Torres A, Luke JD, Kullas AL, Kapilashrami K, Botbol Y, Koller A, Tonge PJ, Chen EI, Macian F, van der Velden AW. Asparagine deprivation mediated by Salmonella asparaginase causes suppression of activation-induced T cell metabolic reprogramming. Journal of Leukocyte Biology. PMID 26497246 DOI: 10.1189/Jlb.4A0615-252R |
0.746 |
|
| 2015 |
Matarlo JS, Evans CE, Sharma I, Lavaud LJ, Ngo SC, Shek R, Rajashankar KR, French JB, Tan DS, Tonge PJ. Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents. Biochemistry. PMID 26394156 DOI: 10.1021/Acs.Biochem.5B00966 |
0.434 |
|
| 2015 |
Touchette MH, Bommineni GR, Delle Bovi RJ, Gadbery JE, Nicora CD, Shukla AK, Kyle JE, Metz TO, Martin DW, Sampson NS, Miller WT, Tonge PJ, Seeliger JC. Diacyltransferase Activity and Chain Length Specificity of Mycobacterium tuberculosis PapA5 in the Synthesis of Alkyl β-Diol Lipids. Biochemistry. 54: 5457-68. PMID 26271001 DOI: 10.1021/Acs.Biochem.5B00455 |
0.368 |
|
| 2015 |
Wang H, Liu L, Lu Y, Pan P, Hooker JM, Fowler JS, Tonge PJ. Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. PMID 26227776 DOI: 10.1016/J.Bmcl.2015.07.019 |
0.515 |
|
| 2015 |
Lai CT, Li HJ, Yu W, Shah S, Bommineni GR, Perrone V, Garcia-Diaz M, Tonge PJ, Simmerling C. Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA. Biochemistry. 54: 4683-91. PMID 26147157 DOI: 10.1021/Acs.Biochem.5B00284 |
0.636 |
|
| 2015 |
Laptenok SP, Lukacs A, Gil A, Brust R, Sazanovich IV, Greetham GM, Tonge PJ, Meech SR. Complete Proton Transfer Cycle in GFP and Its T203V and S205V Mutants. Angewandte Chemie (International Ed. in English). 54: 9303-7. PMID 26087935 DOI: 10.1002/Anie.201503672 |
0.614 |
|
| 2015 |
Walkup GK, You Z, Ross PL, Allen EK, Daryaee F, Hale MR, O'Donnell J, Ehmann DE, Schuck VJ, Buurman ET, Choy AL, Hajec L, Murphy-Benenato K, Marone V, Patey SA, ... ... Tonge PJ, et al. Translating slow-binding inhibition kinetics into cellular and in vivo effects. Nature Chemical Biology. 11: 416-23. PMID 25894085 DOI: 10.1038/Nchembio.1796 |
0.309 |
|
| 2015 |
Schiebel J, Chang A, Merget B, Bommineni GR, Yu W, Spagnuolo LA, Baxter MV, Tareilus M, Tonge PJ, Kisker C, Sotriffer CA. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognition and reduction. Biochemistry. 54: 1943-55. PMID 25706582 DOI: 10.1021/Bi5014358 |
0.436 |
|
| 2015 |
Yu W, Neckles C, Chang A, Bommineni GR, Spagnuolo L, Zhang Z, Liu N, Lai C, Truglio J, Tonge PJ. A [(32)P]NAD(+)-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors. Analytical Biochemistry. 474: 40-9. PMID 25684450 DOI: 10.1016/J.Ab.2014.12.022 |
0.68 |
|
| 2015 |
Perryman AL, Yu W, Wang X, Ekins S, Forli S, Li SG, Freundlich JS, Tonge PJ, Olson AJ. A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA. Journal of Chemical Information and Modeling. 55: 645-59. PMID 25636146 DOI: 10.1021/Ci500672V |
0.366 |
|
| 2015 |
Laptenok SP, Lukacs A, Brust R, Haigney A, Gil A, Towrie M, Greetham GM, Tonge PJ, Meech SR. Electron transfer quenching in light adapted and mutant forms of the AppA BLUF domain. Faraday Discussions. 177: 293-311. PMID 25633480 DOI: 10.1039/C4Fd00189C |
0.811 |
|
| 2015 |
Manjunatha UH, S Rao SP, Kondreddi RR, Noble CG, Camacho LR, Tan BH, Ng SH, Ng PS, Ma NL, Lakshminarayana SB, Herve M, Barnes SW, Yu W, Kuhen K, Blasco F, ... ... Tonge PJ, et al. Direct inhibitors of InhA are active against Mycobacterium tuberculosis. Science Translational Medicine. 7: 269ra3. PMID 25568071 DOI: 10.1126/Scitranslmed.3010597 |
0.344 |
|
| 2015 |
Lai CT, Li HJ, Yu W, Shah S, Bommineni GR, Perrone V, Garcia-Diaz M, Tonge PJ, Simmerling C. Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA Biochemistry. 54: 4683-4691. DOI: 10.1021/acs.biochem.5b00284 |
0.485 |
|
| 2014 |
Schiebel J, Chang A, Shah S, Lu Y, Liu L, Pan P, Hirschbeck MW, Tareilus M, Eltschkner S, Yu W, Cummings JE, Knudson SE, Bommineni GR, Walker SG, Slayden RA, ... ... Tonge PJ, et al. Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor. The Journal of Biological Chemistry. 289: 15987-6005. PMID 24739388 DOI: 10.1074/Jbc.M113.532804 |
0.587 |
|
| 2014 |
Brust R, Haigney A, Lukacs A, Gil A, Hossain S, Addison K, Lai CT, Towrie M, Greetham GM, Clark IP, Illarionov B, Bacher A, Kim RR, Fischer M, Simmerling C, ... ... Tonge PJ, et al. Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii. The Journal of Physical Chemistry Letters. 5: 220-224. PMID 24723998 DOI: 10.1021/Jz4023738 |
0.793 |
|
| 2014 |
Pan P, Knudson SE, Bommineni GR, Li HJ, Lai CT, Liu N, Garcia-Diaz M, Simmerling C, Patil SS, Slayden RA, Tonge PJ. Time-dependent diaryl ether inhibitors of InhA: structure-activity relationship studies of enzyme inhibition, antibacterial activity, and in vivo efficacy. Chemmedchem. 9: 776-91. PMID 24616444 DOI: 10.1002/Cmdc.201300429 |
0.804 |
|
| 2014 |
Lukacs A, Brust R, Haigney A, Laptenok SP, Addison K, Gil A, Towrie M, Greetham GM, Tonge PJ, Meech SR. BLUF domain function does not require a metastable radical intermediate state. Journal of the American Chemical Society. 136: 4605-15. PMID 24579721 DOI: 10.1021/Ja4121082 |
0.804 |
|
| 2014 |
Li HJ, Lai CT, Pan P, Yu W, Liu N, Bommineni GR, Garcia-Diaz M, Simmerling C, Tonge PJ. A structural and energetic model for the slow-onset inhibition of the Mycobacterium tuberculosis enoyl-ACP reductase InhA. Acs Chemical Biology. 9: 986-93. PMID 24527857 DOI: 10.1021/Cb400896G |
0.811 |
|
| 2014 |
Cummings JE, Beaupre AJ, Knudson SE, Liu N, Yu W, Neckles C, Wang H, Khanna A, Bommineni GR, Trunck LA, Schweizer HP, Tonge PJ, Slayden RA. Substituted diphenyl ethers as a novel chemotherapeutic platform against Burkholderia pseudomallei. Antimicrobial Agents and Chemotherapy. 58: 1646-51. PMID 24379198 DOI: 10.1128/Aac.02296-13 |
0.683 |
|
| 2014 |
Cummings JE, Kingry LC, Rholl DA, Schweizer HP, Tonge PJ, Slayden RA. The Burkholderia pseudomallei enoyl-acyl carrier protein reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy. Antimicrobial Agents and Chemotherapy. 58: 931-5. PMID 24277048 DOI: 10.1128/Aac.00176-13 |
0.306 |
|
| 2014 |
Pan P, Knudson SE, Bommineni GR, Li H, Lai C, Liu N, Garcia-Diaz M, Simmerling C, Patil SS, Slayden RA, Tonge PJ. Cover Picture: Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy (ChemMedChem 4/2014) Chemmedchem. 9: 673-673. DOI: 10.1002/Cmdc.201490010 |
0.784 |
|
| 2013 |
Schiebel J, Kapilashrami K, Fekete A, Bommineni GR, Schaefer CM, Mueller MJ, Tonge PJ, Kisker C. Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 288: 34190-204. PMID 24108128 DOI: 10.1074/Jbc.M113.511436 |
0.799 |
|
| 2013 |
Brust R, Lukacs A, Haigney A, Addison K, Gil A, Towrie M, Clark IP, Greetham GM, Tonge PJ, Meech SR. Proteins in action: femtosecond to millisecond structural dynamics of a photoactive flavoprotein. Journal of the American Chemical Society. 135: 16168-74. PMID 24083781 DOI: 10.1021/Ja407265P |
0.793 |
|
| 2013 |
Lukacs A, Haigney A, Brust R, Addison K, Towrie M, Greetham GM, Jones GA, Miyawaki A, Tonge PJ, Meech SR. Protein photochromism observed by ultrafast vibrational spectroscopy. The Journal of Physical Chemistry. B. 117: 11954-9. PMID 24033093 DOI: 10.1021/Jp406142G |
0.804 |
|
| 2013 |
Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D. Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target. Journal of Natural Products. 76: 1064-70. PMID 23806111 DOI: 10.1021/Np400083K |
0.345 |
|
| 2013 |
Chang A, Schiebel J, Yu W, Bommineni GR, Pan P, Baxter MV, Khanna A, Sotriffer CA, Kisker C, Tonge PJ. Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complex. Biochemistry. 52: 4217-28. PMID 23697754 DOI: 10.1021/Bi400413C |
0.572 |
|
| 2013 |
Kapilashrami K, Bommineni GR, Machutta CA, Kim P, Lai CT, Simmerling C, Picart F, Tonge PJ. Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy. The Journal of Biological Chemistry. 288: 6045-52. PMID 23306195 DOI: 10.1074/Jbc.M112.414516 |
0.8 |
|
| 2013 |
Kingry LC, Cummings JE, Brookman KW, Bommineni GR, Tonge PJ, Slayden RA. The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection. Journal of Bacteriology. 195: 351-8. PMID 23144254 DOI: 10.1128/Jb.01957-12 |
0.329 |
|
| 2013 |
Lukacs A, Haigney A, Brust R, Zhao R, Greetham G, Towrie M, Tonge PJ, Meech SR. Transient IR study of blue light sensing proteins Epj Web of Conferences. 41. DOI: 10.1051/epjconf/20134107009 |
0.78 |
|
| 2012 |
Haigney A, Lukacs A, Brust R, Zhao RK, Towrie M, Greetham GM, Clark I, Illarionov B, Bacher A, Kim RR, Fischer M, Meech SR, Tonge PJ. Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA. The Journal of Physical Chemistry. B. 116: 10722-9. PMID 22871066 DOI: 10.1021/Jp305220M |
0.809 |
|
| 2012 |
Schiebel J, Chang A, Lu H, Baxter MV, Tonge PJ, Kisker C. Staphylococcus aureus FabI: inhibition, substrate recognition, and potential implications for in vivo essentiality. Structure (London, England : 1993). 20: 802-13. PMID 22579249 DOI: 10.1016/J.Str.2012.03.013 |
0.52 |
|
| 2012 |
Lukacs A, Zhao RK, Haigney A, Brust R, Greetham GM, Towrie M, Tonge PJ, Meech SR. Excited state structure and dynamics of the neutral and anionic flavin radical revealed by ultrafast transient mid-IR to visible spectroscopy. The Journal of Physical Chemistry. B. 116: 5810-8. PMID 22515837 DOI: 10.1021/Jp2116559 |
0.8 |
|
| 2012 |
Pan P, Tonge PJ. Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds. Current Topics in Medicinal Chemistry. 12: 672-93. PMID 22283812 DOI: 10.2174/156802612799984535 |
0.614 |
|
| 2012 |
Hirschbeck MW, Kuper J, Lu H, Liu N, Neckles C, Shah S, Wagner S, Sotriffer CA, Tonge PJ, Kisker C. Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors. Structure (London, England : 1993). 20: 89-100. PMID 22244758 DOI: 10.1016/J.Str.2011.07.019 |
0.76 |
|
| 2012 |
Lu X, Zhou R, Sharma I, Li X, Kumar G, Swaminathan S, Tonge PJ, Tan DS. Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis. Chembiochem : a European Journal of Chemical Biology. 13: 129-36. PMID 22109989 DOI: 10.1002/Cbic.201100585 |
0.606 |
|
| 2012 |
Kondo M, Heisler IA, Stoner-Ma D, Tonge PJ, Meech SR. Ultrafast proton transfer in the green fluorescent protein: Analysing the instantaneous emission at product state wavelengths Journal of Photochemistry and Photobiology a: Chemistry. 234: 21-26. DOI: 10.1016/J.Jphotochem.2011.12.016 |
0.78 |
|
| 2011 |
Li X, Liu N, Zhang H, Knudson SE, Li HJ, Lai CT, Simmerling C, Slayden RA, Tonge PJ. CoA Adducts of 4-Oxo-4-Phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway. Acs Medicinal Chemistry Letters. 2: 818-823. PMID 22267981 DOI: 10.1021/Ml200141E |
0.807 |
|
| 2011 |
Borgaro JG, Chang A, Machutta CA, Zhang X, Tonge PJ. Substrate recognition by β-ketoacyl-ACP synthases. Biochemistry. 50: 10678-86. PMID 22017312 DOI: 10.1021/Bi201199X |
0.806 |
|
| 2011 |
Lukacs A, Haigney A, Brust R, Zhao RK, Stelling AL, Clark IP, Towrie M, Greetham GM, Meech SR, Tonge PJ. Photoexcitation of the blue light using FAD photoreceptor AppA results in ultrafast changes to the protein matrix. Journal of the American Chemical Society. 133: 16893-900. PMID 21899315 DOI: 10.1021/Ja2060098 |
0.801 |
|
| 2011 |
Zhao RK, Lukacs A, Haigney A, Brust R, Greetham GM, Towrie M, Tonge PJ, Meech SR. Ultrafast transient mid IR to visible spectroscopy of fully reduced flavins. Physical Chemistry Chemical Physics : Pccp. 13: 17642-8. PMID 21887430 DOI: 10.1039/C1Cp22097G |
0.796 |
|
| 2011 |
Li HJ, Li X, Liu N, Zhang H, Truglio JJ, Mishra S, Kisker C, Garcia-Diaz M, Tonge PJ. Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member. Biochemistry. 50: 9532-44. PMID 21830810 DOI: 10.1021/Bi200877X |
0.813 |
|
| 2011 |
Lee W, Luckner SR, Kisker C, Tonge PJ, Engels B. Elucidation of the protonation states of the catalytic residues in mtKasA: implications for inhibitor design. Biochemistry. 50: 5743-56. PMID 21615093 DOI: 10.1021/Bi200006T |
0.44 |
|
| 2011 |
Kinnings SL, Liu N, Tonge PJ, Jackson RM, Xie L, Bourne PE. Correction to "Machine learning-based method to improve docking scoring functions and its application to drug repurposing". Journal of Chemical Information and Modeling. 51: 1195-7. PMID 21526828 DOI: 10.1021/Ci2001346 |
0.617 |
|
| 2011 |
Liu N, Cummings JE, England K, Slayden RA, Tonge PJ. Mechanism and inhibition of the FabI enoyl-ACP reductase from Burkholderia pseudomallei. The Journal of Antimicrobial Chemotherapy. 66: 564-73. PMID 21393229 DOI: 10.1093/Jac/Dkq509 |
0.704 |
|
| 2011 |
Kinnings SL, Liu N, Tonge PJ, Jackson RM, Xie L, Bourne PE. A machine learning-based method to improve docking scoring functions and its application to drug repurposing. Journal of Chemical Information and Modeling. 51: 408-19. PMID 21291174 DOI: 10.1021/Ci100369F |
0.663 |
|
| 2011 |
Haigney A, Lukacs A, Zhao RK, Stelling AL, Brust R, Kim RR, Kondo M, Clark I, Towrie M, Greetham GM, Illarionov B, Bacher A, Römisch-Margl W, Fischer M, Meech SR, ... Tonge PJ, et al. Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein Biochemistry. 50: 1321-1328. PMID 21218799 DOI: 10.1021/Bi101589A |
0.802 |
|
| 2011 |
Zhang Z, Zhou R, Sauder JM, Tonge PJ, Burley SK, Swaminathan S. Structural and functional studies of fatty acyl adenylate ligases from E. coli and L. pneumophila. Journal of Molecular Biology. 406: 313-24. PMID 21185305 DOI: 10.1016/J.Jmb.2010.12.011 |
0.399 |
|
| 2011 |
Kumar K, Awasthi D, Lee SY, Zanardi I, Ruzsicska B, Knudson S, Tonge PJ, Slayden RA, Ojima I. Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. Journal of Medicinal Chemistry. 54: 374-81. PMID 21126020 DOI: 10.1021/Jm1012006 |
0.331 |
|
| 2010 |
Kumar K, Awasthi D, Berger WT, Tonge PJ, Slayden RA, Ojima I. Discovery of anti-TB agents that target the cell-division protein FtsZ. Future Medicinal Chemistry. 2: 1305-23. PMID 21339840 DOI: 10.4155/Fmc.10.220 |
0.342 |
|
| 2010 |
Li X, Liu N, Zhang H, Knudson SE, Slayden RA, Tonge PJ. Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters. 20: 6306-9. PMID 20850304 DOI: 10.1016/J.Bmcl.2010.08.076 |
0.782 |
|
| 2010 |
Lu H, Tonge PJ. Drug-target residence time: critical information for lead optimization. Current Opinion in Chemical Biology. 14: 467-74. PMID 20663707 DOI: 10.1016/J.Cbpa.2010.06.176 |
0.434 |
|
| 2010 |
Luckner SR, Liu N, am Ende CW, Tonge PJ, Kisker C. A slow, tight binding inhibitor of InhA, the enoyl-acyl carrier protein reductase from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 285: 14330-7. PMID 20200152 DOI: 10.1074/Jbc.M109.090373 |
0.715 |
|
| 2010 |
Lu H, Tonge PJ. Mechanism and inhibition of the FabV enoyl-ACP reductase from Burkholderia mallei. Biochemistry. 49: 1281-9. PMID 20055482 DOI: 10.1021/Bi902001A |
0.56 |
|
| 2010 |
Machutta CA, Bommineni GR, Luckner SR, Kapilashrami K, Ruzsicska B, Simmerling C, Kisker C, Tonge PJ. Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin. The Journal of Biological Chemistry. 285: 6161-9. PMID 20018879 DOI: 10.1074/Jbc.M109.077909 |
0.803 |
|
| 2010 |
Kondo M, Heisler IA, Stoner-Ma D, Tonge PJ, Meech SR. Ultrafast dynamics of protein proton transfer on short hydrogen bond potential energy surfaces: S65T/H148D GFP. Journal of the American Chemical Society. 132: 1452-3. PMID 19916498 DOI: 10.1021/Ja907690G |
0.784 |
|
| 2010 |
Lukacs A, Haigney A, Kondo M, Brust R, Gretham G, Towrie M, Tonge PJ, TongeMeech SR. Ultrafast dynamics of the BLUF mutant dAppA Q63E revealed by TRIR and fluorescent upconversion Optics Infobase Conference Papers. |
0.793 |
|
| 2010 |
Zhang H, Machutta CA, Tonge PJ. Fatty acid biosynthesis and oxidation Comprehensive Natural Products Ii: Chemistry and Biology. 8: 231-275. |
0.455 |
|
| 2009 |
England K, am Ende C, Lu H, Sullivan TJ, Marlenee NL, Bowen RA, Knudson SE, Knudson DL, Tonge PJ, Slayden RA. Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia. The Journal of Antimicrobial Chemotherapy. 64: 1052-61. PMID 19734171 DOI: 10.1093/Jac/Dkp307 |
0.637 |
|
| 2009 |
Luckner SR, Machutta CA, Tonge PJ, Kisker C. Crystal structures of Mycobacterium tuberculosis KasA show mode of action within cell wall biosynthesis and its inhibition by thiolactomycin. Structure (London, England : 1993). 17: 1004-13. PMID 19604480 DOI: 10.1016/J.Str.2009.04.012 |
0.364 |
|
| 2009 |
Kinnings SL, Liu N, Buchmeier N, Tonge PJ, Xie L, Bourne PE. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. Plos Computational Biology. 5: e1000423. PMID 19578428 DOI: 10.1371/Journal.Pcbi.1000423 |
0.676 |
|
| 2009 |
Lu H, England K, am Ende C, Truglio JJ, Luckner S, Reddy BG, Marlenee NL, Knudson SE, Knudson DL, Bowen RA, Kisker C, Slayden RA, Tonge PJ. Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity. Acs Chemical Biology. 4: 221-31. PMID 19206187 DOI: 10.1021/Cb800306Y |
0.519 |
|
| 2009 |
Tonge PJ, Meech SR. Excited state dynamics in the green fluorescent protein Journal of Photochemistry and Photobiology a: Chemistry. 205: 1-11. DOI: 10.1016/J.Jphotochem.2009.03.021 |
0.352 |
|
| 2008 |
Stoner-Ma D, Jaye AA, Ronayne KL, Nappa J, Tonge PJ, Meech SR. Ultrafast Electronic and Vibrational Dynamics of Stabilized A State Mutants of the Green Fluorescent Protein (GFP): Snipping the Proton Wire. Chemical Physics. 350: 193-200. PMID 19554079 DOI: 10.1016/J.Chemphys.2008.02.021 |
0.797 |
|
| 2008 |
Lu X, Zhang H, Tonge PJ, Tan DS. Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis. Bioorganic & Medicinal Chemistry Letters. 18: 5963-6. PMID 18762421 DOI: 10.1016/J.Bmcl.2008.07.130 |
0.611 |
|
| 2008 |
Kruh NA, Borgaro JG, Ruzsicska BP, Xu H, Tonge PJ. A novel interaction linking the FAS-II and phthiocerol dimycocerosate (PDIM) biosynthetic pathways. The Journal of Biological Chemistry. 283: 31719-25. PMID 18703500 DOI: 10.1074/Jbc.M802169200 |
0.778 |
|
| 2008 |
Respicio L, Nair PA, Huang Q, Anil B, Tracz S, Truglio JJ, Kisker C, Raleigh DP, Ojima I, Knudson DL, Tonge PJ, Slayden RA. Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery. Tuberculosis (Edinburgh, Scotland). 88: 420-9. PMID 18479968 DOI: 10.1016/J.Tube.2008.03.001 |
0.73 |
|
| 2008 |
am Ende CW, Knudson SE, Liu N, Childs J, Sullivan TJ, Boyne M, Xu H, Gegina Y, Knudson DL, Johnson F, Peloquin CA, Slayden RA, Tonge PJ. Synthesis and in vitro antimycobacterial activity of B-ring modified diaryl ether InhA inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 3029-33. PMID 18457948 DOI: 10.1016/J.Bmcl.2008.04.038 |
0.754 |
|
| 2008 |
Karioti A, Skaltsa H, Zhang X, Tonge PJ, Perozzo R, Kaiser M, Franzblau SG, Tasdemir D. Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 15: 1125-9. PMID 18424102 DOI: 10.1016/J.Phymed.2008.02.018 |
0.359 |
|
| 2008 |
Malo GD, Wang M, Wu D, Stelling AL, Tonge PJ, Wachter RM. Crystal structure and Raman studies of dsFP483, a cyan fluorescent protein from Discosoma striata. Journal of Molecular Biology. 378: 871-86. PMID 18395223 DOI: 10.1016/J.Jmb.2008.02.069 |
0.707 |
|
| 2008 |
Xu H, Sullivan TJ, Sekiguchi J, Kirikae T, Ojima I, Stratton CF, Mao W, Rock FL, Alley MR, Johnson F, Walker SG, Tonge PJ. Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus. Biochemistry. 47: 4228-36. PMID 18335995 DOI: 10.1021/Bi800023A |
0.669 |
|
| 2008 |
Lu H, Tonge PJ. Inhibitors of FabI, an enzyme drug target in the bacterial fatty acid biosynthesis pathway. Accounts of Chemical Research. 41: 11-20. PMID 18193820 DOI: 10.1021/Ar700156E |
0.535 |
|
| 2008 |
Stoner-Ma D, Jaye AA, Ronayne KL, Nappa J, Meech SR, Tonge PJ. An alternate proton acceptor for excited-state proton transfer in green fluorescent protein: rewiring GFP. Journal of the American Chemical Society. 130: 1227-35. PMID 18179211 DOI: 10.1021/Ja0754507 |
0.801 |
|
| 2007 |
Stelling AL, Ronayne KL, Nappa J, Tonge PJ, Meech SR. Ultrafast structural dynamics in BLUF domains: transient infrared spectroscopy of AppA and its mutants. Journal of the American Chemical Society. 129: 15556-64. PMID 18031038 DOI: 10.1021/Ja074074N |
0.714 |
|
| 2007 |
Tasdemir D, Topaloglu B, Perozzo R, Brun R, O'Neill R, Carballeira NM, Zhang X, Tonge PJ, Linden A, Rüedi P. Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli. Bioorganic & Medicinal Chemistry. 15: 6834-45. PMID 17765547 DOI: 10.1016/J.Bmc.2007.07.032 |
0.349 |
|
| 2007 |
Boyne ME, Sullivan TJ, amEnde CW, Lu H, Gruppo V, Heaslip D, Amin AG, Chatterjee D, Lenaerts A, Tonge PJ, Slayden RA. Targeting fatty acid biosynthesis for the development of novel chemotherapeutics against Mycobacterium tuberculosis: evaluation of A-ring-modified diphenyl ethers as high-affinity InhA inhibitors. Antimicrobial Agents and Chemotherapy. 51: 3562-7. PMID 17664324 DOI: 10.1128/Aac.00383-07 |
0.67 |
|
| 2007 |
Kruh NA, Rawat R, Ruzsicska BP, Tonge PJ. Probing mechanisms of resistance to the tuberculosis drug isoniazid: Conformational changes caused by inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis. Protein Science : a Publication of the Protein Society. 16: 1617-27. PMID 17600151 DOI: 10.1110/Ps.062749007 |
0.809 |
|
| 2007 |
Bonnac L, Gao GY, Chen L, Felczak K, Bennett EM, Xu H, Kim T, Liu N, Oh H, Tonge PJ, Pankiewicz KW. Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters. 17: 4588-91. PMID 17560106 DOI: 10.1016/J.Bmcl.2007.05.084 |
0.677 |
|
| 2007 |
Bell AF, Stratton CF, Zhang X, Novichenok P, Jaye AA, Nair PA, Parikh S, Rawat R, Tonge PJ. Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis. Journal of the American Chemical Society. 129: 6425-31. PMID 17472376 DOI: 10.1021/Ja068219M |
0.788 |
|
| 2007 |
Huang Q, Tonge PJ, Slayden RA, Kirikae T, Ojima I. FtsZ: a novel target for tuberculosis drug discovery. Current Topics in Medicinal Chemistry. 7: 527-43. PMID 17346197 DOI: 10.2174/156802607780059790 |
0.342 |
|
| 2007 |
Tonge PJ, Kisker C, Slayden RA. Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis. Current Topics in Medicinal Chemistry. 7: 489-98. PMID 17346194 DOI: 10.2174/156802607780059781 |
0.358 |
|
| 2007 |
Zwahlen J, Kolappan S, Zhou R, Kisker C, Tonge PJ. Structure and mechanism of MbtI, the salicylate synthase from Mycobacterium tuberculosis. Biochemistry. 46: 954-64. PMID 17240979 DOI: 10.1021/Bi060852X |
0.768 |
|
| 2007 |
Kolappan S, Zwahlen J, Zhou R, Truglio JJ, Tonge PJ, Kisker C. Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family. Biochemistry. 46: 946-53. PMID 17240978 DOI: 10.1021/Bi0608515 |
0.765 |
|
| 2006 |
Sullivan TJ, Truglio JJ, Boyne ME, Novichenok P, Zhang X, Stratton CF, Li HJ, Kaur T, Amin A, Johnson F, Slayden RA, Kisker C, Tonge PJ. High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis. Acs Chemical Biology. 1: 43-53. PMID 17163639 DOI: 10.1021/Cb0500042 |
0.786 |
|
| 2006 |
Stoner-Ma D, Melief EH, Nappa J, Ronayne KL, Tonge PJ, Meech SR. Proton relay reaction in green fluorescent protein (GFP): Polarization-resolved ultrafast vibrational spectroscopy of isotopically edited GFP. The Journal of Physical Chemistry. B. 110: 22009-18. PMID 17064171 DOI: 10.1021/Jp065326U |
0.791 |
|
| 2006 |
Kondo M, Nappa J, Ronayne KL, Stelling AL, Tonge PJ, Meech SR. Ultrafast vibrational spectroscopy of the flavin chromophore. The Journal of Physical Chemistry. B. 110: 20107-10. PMID 17034182 DOI: 10.1021/Jp0650735 |
0.697 |
|
| 2006 |
Rafi S, Novichenok P, Kolappan S, Zhang X, Stratton CF, Rawat R, Kisker C, Simmerling C, Tonge PJ. Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli. The Journal of Biological Chemistry. 281: 39285-93. PMID 17012233 DOI: 10.1074/Jbc.M608758200 |
0.811 |
|
| 2006 |
Rafi SB, Cui G, Song K, Cheng X, Tonge PJ, Simmerling C. Insight through molecular mechanics Poisson-Boltzmann surface area calculations into the binding affinity of triclosan and three analogues for FabI, the E. coli enoyl reductase. Journal of Medicinal Chemistry. 49: 4574-80. PMID 16854062 DOI: 10.1021/Jm060222T |
0.35 |
|
| 2006 |
Callahan BP, Bell AF, Tonge PJ, Wolfenden R. A Raman-active competitive inhibitor of OMP decarboxylase. Bioorganic Chemistry. 34: 59-65. PMID 16457871 DOI: 10.1016/J.Bioorg.2005.12.001 |
0.371 |
|
| 2006 |
Huang Q, Kirikae F, Kirikae T, Pepe A, Amin A, Respicio L, Slayden RA, Tonge PJ, Ojima I. Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents. Journal of Medicinal Chemistry. 49: 463-6. PMID 16420032 DOI: 10.1021/Jm050920Y |
0.307 |
|
| 2006 |
Jaye AA, Stoner-Ma D, Matousek P, Towrie M, Tonge PJ, Meech SR. Time-resolved emission spectra of green fluorescent protein Photochemistry and Photobiology. 82: 373-379. DOI: 10.1562/2005-05-07-Ra-518 |
0.78 |
|
| 2005 |
Carlisle-Moore L, Gordon CR, Machutta CA, Miller WT, Tonge PJ. Substrate recognition by the human fatty-acid synthase. The Journal of Biological Chemistry. 280: 42612-8. PMID 16215233 DOI: 10.1074/Jbc.M507082200 |
0.783 |
|
| 2005 |
Doll C, Bell AF, Power N, Tonge PJ, Tipton PA. Procatalytic ligand strain. Ionization and perturbation of 8-nitroxanthine at the urate oxidase active site. Biochemistry. 44: 11440-6. PMID 16114880 DOI: 10.1021/Bi0507837 |
0.371 |
|
| 2005 |
Wu J, Bell AF, Jaye AA, Tonge PJ. Ring current effects in the active site of medium-chain Acyl-CoA dehydrogenase revealed by NMR spectroscopy. Journal of the American Chemical Society. 127: 8424-32. PMID 15941276 DOI: 10.1021/Ja050083P |
0.566 |
|
| 2005 |
Stoner-Ma D, Jaye AA, Matousek P, Towrie M, Meech SR, Tonge PJ. Observation of excited-state proton transfer in green fluorescent protein using ultrafast vibrational spectroscopy. Journal of the American Chemical Society. 127: 2864-5. PMID 15740117 DOI: 10.1021/Ja042466D |
0.798 |
|
| 2005 |
Vengris M, Stokkum IHMv, He X, Bell AF, Tonge PJ, Grondelle Rv, Larsen DS. Ultrafast excited and ground-state isomerization dynamics of the Green Fluorescent Protein chromophore in solution Springer Series in Chemical Physics. 79: 610-612. DOI: 10.1007/3-540-27213-5_186 |
0.482 |
|
| 2004 |
Sivaraman S, Sullivan TJ, Johnson F, Novichenok P, Cui G, Simmerling C, Tonge PJ. Inhibition of the bacterial enoyl reductase FabI by triclosan: a structure-reactivity analysis of FabI inhibition by triclosan analogues. Journal of Medicinal Chemistry. 47: 509-18. PMID 14736233 DOI: 10.1021/Jm030182I |
0.795 |
|
| 2004 |
Vengris M, Van Stokkum IHM, He X, Bell AF, Tonge PJ, Van Grondelle R, Larsen DS. Ultrafast excited and ground-state dynamics of the green fluorescent protein chromophore in solution Journal of Physical Chemistry A. 108: 4587-4598. DOI: 10.1021/Jp037902H |
0.489 |
|
| 2003 |
Rawat R, Whitty A, Tonge PJ. The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance. Proceedings of the National Academy of Sciences of the United States of America. 100: 13881-6. PMID 14623976 DOI: 10.1073/Pnas.2235848100 |
0.638 |
|
| 2003 |
Wu J, Bell AF, Luo L, Stephens AW, Stankovich MT, Tonge PJ. Probing hydrogen-bonding interactions in the active site of medium-chain acyl-CoA dehydrogenase using Raman spectroscopy. Biochemistry. 42: 11846-56. PMID 14529297 DOI: 10.1021/Bi0344578 |
0.643 |
|
| 2003 |
He X, Bell AF, Tonge PJ. Ground state isomerization of a model green fluorescent protein chromophore. Febs Letters. 549: 35-8. PMID 12914920 DOI: 10.1016/S0014-5793(03)00761-0 |
0.487 |
|
| 2003 |
Truglio JJ, Theis K, Feng Y, Gajda R, Machutta C, Tonge PJ, Kisker C. Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis. The Journal of Biological Chemistry. 278: 42352-60. PMID 12909628 DOI: 10.1074/Jbc.M307399200 |
0.645 |
|
| 2003 |
Bell AF, Stoner-Ma D, Wachter RM, Tonge PJ. Light-driven decarboxylation of wild-type green fluorescent protein. Journal of the American Chemical Society. 125: 6919-26. PMID 12783544 DOI: 10.1021/Ja034588W |
0.797 |
|
| 2003 |
Sivaraman S, Zwahlen J, Bell AF, Hedstrom L, Tonge PJ. Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs. Biochemistry. 42: 4406-13. PMID 12693936 DOI: 10.1021/Bi0300229 |
0.805 |
|
| 2003 |
Boyé S, Krogh H, Nielsen IB, Nielsen SB, Pedersen SU, Pedersen UV, Andersen LH, Bell AF, He X, Tonge PJ. Vibrationally resolved photoabsorption spectroscopy of red fluorescent protein chromophore anions. Physical Review Letters. 90: 118103. PMID 12688970 DOI: 10.1103/PhysRevLett.90.118103 |
0.427 |
|
| 2003 |
Boyé S, Nielsen SB, Krogh H, Nielsen IB, Pedersen UV, Bell AF, He X, Tonge PJ, Andersen LH. Gas-phase absorption properties of DsRed model chromophores Physical Chemistry Chemical Physics. 5: 3021-3026. DOI: 10.1039/B304956F |
0.472 |
|
| 2002 |
Bell AF, Feng Y, Hofstein HA, Parikh S, Wu J, Rudolph MJ, Kisker C, Whitty A, Tonge PJ. Stereoselectivity of enoyl-CoA hydratase results from preferential activation of one of two bound substrate conformers. Chemistry & Biology. 9: 1247-55. PMID 12445775 DOI: 10.1016/S1074-5521(02)00263-6 |
0.808 |
|
| 2002 |
Feng Y, Hofstein HA, Zwahlen J, Tonge PJ. Effect of mutagenesis on the stereochemistry of enoyl-CoA hydratase. Biochemistry. 41: 12883-90. PMID 12379132 DOI: 10.1021/Bi020382G |
0.783 |
|
| 2002 |
He X, Bell AF, Tonge PJ. Synthesis and spectroscopic studies of model red fluorescent protein chromophores. Organic Letters. 4: 1523-6. PMID 11975619 DOI: 10.1021/Ol0200403 |
0.454 |
|
| 2002 |
He X, Bell AF, Tonge PJ. Isotopic labeling and normal-mode analysis of a model green fluorescent protein chromophore Journal of Physical Chemistry B. 106: 6056-6066. DOI: 10.1021/Jp0145560 |
0.472 |
|
| 2001 |
Dai M, Feng Y, Tonge PJ. Synthesis of crotonyl-oxyCoA: a mechanistic probe of the reaction catalyzed by enoyl-CoA hydratase. Journal of the American Chemical Society. 123: 506-7. PMID 11456558 DOI: 10.1021/Ja003406K |
0.541 |
|
| 2001 |
Bell AF, Wu J, Feng Y, Tonge PJ. Involvement of glycine 141 in substrate activation by enoyl-CoA hydratase. Biochemistry. 40: 1725-33. PMID 11327833 DOI: 10.1021/Bi001733Z |
0.726 |
|
| 2001 |
Bell AF, He X, Ridge JP, Hanson GR, McEwan AG, Tonge PJ. Active site heterogeneity in dimethyl sulfoxide reductase from Rhodobacter capsulatus revealed by Raman spectroscopy. Biochemistry. 40: 440-8. PMID 11148038 DOI: 10.1021/Bi002065K |
0.517 |
|
| 2000 |
Pellett JD, Sabaj KM, Stephens AW, Bell AF, Wu J, Tonge PJ, Stankovich MT. Medium-chain acyl-coenzyme A dehydrogenase bound to a product analogue, hexadienoyl-coenzyme A: effects on reduction potential, pK(a), and polarization. Biochemistry. 39: 13982-92. PMID 11076541 DOI: 10.1021/Bi0006464 |
0.617 |
|
| 2000 |
Parikh SL, Xiao G, Tonge PJ. Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid. Biochemistry. 39: 7645-50. PMID 10869170 DOI: 10.1021/Bi0008940 |
0.807 |
|
| 2000 |
Bell AF, He X, Wachter RM, Tonge PJ. Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy. Biochemistry. 39: 4423-31. PMID 10757992 DOI: 10.1021/Bi992675O |
0.54 |
|
| 2000 |
Tonge PJ. Another brick in the wall Nature Structural Biology. 7: 94-96. PMID 10655605 DOI: 10.1038/72458 |
0.325 |
|
| 2000 |
Rudik I, Bell A, Tonge PJ, Thorpe C. 4-Hydroxycinnamoyl-CoA: an ionizable probe of the active site of the medium chain acyl-CoA dehydrogenase. Biochemistry. 39: 92-101. PMID 10625483 DOI: 10.1021/Bi9915364 |
0.384 |
|
| 2000 |
Wu WJ, Feng Y, He X, Hofstein HA, Raleigh DP, Tonge PJ. Stereospecificity of the reaction catalyzed by enoyl-CoA hydratase Journal of the American Chemical Society. 122: 3987-3994. DOI: 10.1021/Ja992286H |
0.643 |
|
| 1999 |
Parikh S, Moynihan DP, Xiao G, Tonge PJ. Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis Biochemistry. 38: 13623-13634. PMID 10521269 DOI: 10.1021/Bi990529C |
0.818 |
|
| 1999 |
Stankovich MT, Sabaj KM, Tonge PJ. Structure/function of medium chain Acyl-CoA dehydrogenase: The importance of substrate polarization Archives of Biochemistry and Biophysics. 370: 16-21. PMID 10496972 DOI: 10.1006/Abbi.1999.1385 |
0.31 |
|
| 1999 |
Hofstein HA, Feng Y, Anderson VE, Tonge PJ. Role of glutamate 144 and glutamate 164 in the catalytic mechanism of enoyl-CoA hydratase. Biochemistry. 38: 9508-16. PMID 10413528 DOI: 10.1021/Bi990506Y |
0.61 |
|
| 1999 |
Stewart MJ, Parikh S, Xiao G, Tonge PJ, Kisker C. Structural basis and mechanism of enoyl reductase inhibition by triclosan. Journal of Molecular Biology. 290: 859-65. PMID 10398587 DOI: 10.1006/Jmbi.1999.2907 |
0.806 |
|
| 1998 |
Wu WJ, Tonge PJ, Raleigh DP. Stereospecific 1H and 13C NMR assignments of crotonyl CoA and hexadienoyl CoA: Conformational analysis and comparison with protein-CoA complexes Journal of the American Chemical Society. 120: 9988-9994. DOI: 10.1021/Ja982243L |
0.348 |
|
| 1997 |
Clarkson J, Tonge PJ, Taylor KL, Dunaway-Mariano D, Carey PR. Raman study of the polarizing forces promoting catalysis in 4-chlorobenzoate-CoA dehalogenase. Biochemistry. 36: 10192-9. PMID 9254617 DOI: 10.1021/Bi970941X |
0.338 |
|
| 1997 |
Wu WJ, Anderson VE, Raleigh DP, Tonge PJ. Structure of hexadienoyl-coa bound to enoyl-coa hydratase determined by transferred nuclear overhauser effect measurements: Mechanistic predictions based on the x-ray structure of 4-(chlorobenzoyl)-coa dehalogenaset Biochemistry. 36: 2211-2220. PMID 9047322 DOI: 10.1021/Bi962549+ |
0.403 |
|
| 1997 |
Tonge PJ, Carey PR, Fausto R. Molecular structure of S-ethyl thioacrylate: Combined vibrational spectroscopic and ab initio SCF-MO study Journal of the Chemical Society - Faraday Transactions. 93: 3619-3624. DOI: 10.1039/A703448B |
0.313 |
|
| 1996 |
Doran JD, Tonge PJ, Mort JS, Carey PR. Deacylation and reacylation for a series of acyl cysteine proteases, including acyl groups derived from novel chromophoric substrates Biochemistry. 35: 12487-12494. PMID 8823184 DOI: 10.1021/Bi960648H |
0.388 |
|
| 1995 |
Taylor KL, Liu RQ, Liang PH, Price J, Dunaway-Mariano D, Tonge PJ, Clarkson J, Carey PR. Evidence for electrophilic catalysis in the 4-chlorobenzoyl-CoA dehalogenase reaction: UV, Raman, and 13C-NMR spectral studies of dehalogenase complexes of benzoyl-CoA adducts. Biochemistry. 34: 13881-8. PMID 7577982 DOI: 10.1021/Bi00042A020 |
0.415 |
|
| 1995 |
Tonge PJ, Anderson VE, Fausto R, Kim M, Pusztai-Carey M, Carey PR. Localized electron polarization in a substrate analog binding to the active site of enoyl-CoA hydratase: Raman spectroscopic and conformational analyses of rotamers of hexadienoyl thiolesters Biospectroscopy. 1: 387-394. DOI: 10.1002/Bspy.350010604 |
0.386 |
|
| 1994 |
D'Ordine RL, Bahnson BJ, Tonge PJ, Anderson VE. Enoyl-coenzyme A hydratase-catalyzed exchange of the alpha-protons of coenzyme A thiol esters: a model for an enolized intermediate in the enzyme-catalyzed elimination? Biochemistry. 33: 14733-42. PMID 7993901 DOI: 10.1021/Bi00253A011 |
0.341 |
|
| 1994 |
D'Ordine RL, Tonge PJ, Carey PR, Anderson VE. Electronic rearrangement induced by substrate analog binding to the enoyl-CoA hydratase active site: evidence for substrate activation. Biochemistry. 33: 12635-43. PMID 7918489 DOI: 10.1021/Bi00208A014 |
0.384 |
|
| 1994 |
Doran JD, Tonge PJ, Kim M, Carey PR. Facile characterization of the spectra of cis and trans photoisomers in a mixture of acyl-enzymes by Raman difference spectroscopy Photochemistry and Photobiology. 60: 432-434. DOI: 10.1111/J.1751-1097.1994.Tb05129.X |
0.306 |
|
| 1994 |
Fausto R, Martins AG, Teixeira-Dias JJC, Tonge PJ, Carey PR. Rotational isomerism in CH3CH2-C(=S)SR (R = CH3, CH2CH3): A combined vibrational spectroscopic and ab Initio study Journal of Physical Chemistry. 98: 3592-3600. DOI: 10.1021/J100065A010 |
0.332 |
|
| 1994 |
Fausto R, Gabriela Martins A, Teixeira-Dias JJC, Tonge PJ, Carey PR. Rotational isomerism in CH3C(S)SCH3 and CH3C(S)SCH2CH3: a combined vibrational spectroscopic and ab initio study Journal of Molecular Structure. 323: 59-69. DOI: 10.1016/0022-2860(94)07979-X |
0.312 |
|
| 1993 |
Tonge PJ, Carey PR, Callender R, Deng H, Ekiel I, Muhandiram DR. Characterization of trans- and cis-5-methylthienylacryloyl chymotrypsin using Raman difference spectroscopy, NMR, and kinetics: Carbonyl environment and reactivity Journal of the American Chemical Society. 115: 8757-8762. DOI: 10.1021/Ja00072A031 |
0.348 |
|
| 1992 |
Tonge PJ, Gour-Salin B, Lachance P, Storer AC, Carey PR. Resonance Raman spectroscopic and kinetic consequences of a nitrogen ... sulphur enzyme-substrate contact in a series of dithioacylpapains. Biophysical Journal. 63: 191-6. PMID 1420866 DOI: 10.1016/S0006-3495(92)81591-6 |
0.336 |
|
| 1992 |
Tonge PJ, Carey PR. Forces, bond lengths, and reactivity: Fundamental insight into the mechanism of enzyme catalysis Biochemistry. 31: 9122-9125. PMID 1390699 DOI: 10.1021/Bi00153A002 |
0.347 |
|
| 1992 |
Tonge PJ, Carey PR, Anderson VE. Multiple forms of thioacetyl coenzyme a binding to citrate synthase. Resonance raman evidence Journal of the American Chemical Society. 114: 8738-8739. DOI: 10.1021/Ja00048A078 |
0.306 |
|
| 1991 |
Tonge PJ, Pusztai M, White AJ, Wharton CW, Carey PR. Resonance Raman and Fourier transform infrared spectroscopic studies of the acyl carbonyl group in [3-(5-methyl-2-thienyl)acryloyl]chymotrypsin: Evidence for artifacts in the spectra obtained by both techniques Biochemistry. 30: 4790-4795. PMID 2029519 DOI: 10.1021/Bi00233A021 |
0.369 |
|
| 1990 |
Tonge PJ, Carey PR. Length of the acyl carbonyl bond in acyl-serine proteases correlates with reactivity Biochemistry. 29: 10723-10727. PMID 2271679 DOI: 10.1021/Bi00500A002 |
0.337 |
|
| 1990 |
Carey PR, Tonge PJ. Chemistry of enzyme-substrate complexes revealed by resonance Raman spectroscopy Chemical Society Reviews. 19: 293-316. DOI: 10.1039/Cs9901900293 |
0.33 |
|
| 1989 |
Tonge PJ, Carey PR. Direct observation of the titration of substrate carbonyl groups in the active site of α-chymotrypsin by resonance Raman spectroscopy Biochemistry. 28: 6701-6709. PMID 2790025 DOI: 10.1021/Bi00442A025 |
0.389 |
|
| 1989 |
Tonge PJ, Lee H, Sans Cartier LR, Ruzsicska BP, Carey PR. Striking changes observed in key acyl-enzyme linkages by resonance Raman experiments near 77 K Journal of the American Chemical Society. 111: 1496-1497. DOI: 10.1021/Ja00186A055 |
0.322 |
|
| 1989 |
Tonge PJ, Carrey PR. Resonance Raman and absorption spectroscopic characterization of the chemically engineered enzyme thiolsubtilisin; comparison with a natural thiolenzyme Journal of Molecular Liquids. 42: 195-212. DOI: 10.1016/0167-7322(89)80034-0 |
0.378 |
|
| Show low-probability matches. |
