Lai Y. Leung, Ph.D. - Publications

Affiliations: 
2010 Biomedical Engineering Wayne State University, Detroit, MI, United States 
Area:
Biomedical, Biomechanics

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li X, Pierre K, Yang Z, Nguyen L, Johnson G, Venetucci J, Torres I, Lucke-Wold B, Shi Y, Boutte A, Shear D, Leung LY, Wang KKW. Blood-Based Brain and Global Biomarker Changes after Combined Hypoxemia and Hemorrhagic Shock in a Rat Model of Penetrating Ballistic-Like Brain Injury. Neurotrauma Reports. 2: 370-380. PMID 34901937 DOI: 10.1089/neur.2021.0006  0.377
2021 Pandya JD, Leung LY, Hwang HM, Yang X, Deng-Bryant Y, Shear DA. Time-course Evaluation of Brain Regional Mitochondrial Bioenergetics in a Preclinical Model of Severe Penetrating Traumatic Brain Injury. Journal of Neurotrauma. PMID 33544034 DOI: 10.1089/neu.2020.7379  0.391
2020 Bailey ZS, Leung LY, Yang X, Cardiff K, Gilsdorf J, Shear D, Kochanek PM. Pre-Hospital Whole Blood Resuscitation Reduces Fluid Requirement While Maintaining Critical Physiology in a Model of Penetrating Traumatic Brain Injury and Hemorrhage: Implications on Resource-Limited Combat Casualty Care. Shock (Augusta, Ga.). PMID 32925600 DOI: 10.1097/Shk.0000000000001662  0.394
2020 Zusman BE, Kochanek PM, Bailey ZS, Leung LY, Vagni VA, Okonkwo DO, Puccio AM, Shutter LA, Janesko-Feldman KL, Gilsdorf JS, Shear DA, Jha RM. Multifaceted Benefit of Whole Blood Versus Lactated Ringer's Resuscitation After Traumatic Brain Injury and Hemorrhagic Shock in Mice. Neurocritical Care. PMID 32886294 DOI: 10.1007/S12028-020-01084-1  0.454
2019 Bailey ZS, Cardiff K, Yang X, Gilsdorf J, Shear D, Rasmussen TE, Leung LY. The Effects of Balloon Occlusion of the Aorta on Cerebral Blood Flow, Intracranial Pressure, and Brain Tissue Oxygen Tension in a Rodent Model of Penetrating Ballistic-Like Brain Injury. Frontiers in Neurology. 10: 1309. PMID 31920932 DOI: 10.3389/Fneur.2019.01309  0.429
2019 Wilfred BS, Madathil SK, Cardiff K, Urankar S, Yang X, Hwang HM, Gilsdorf J, Shear DA, Leung LY. Alterations in peripheral organs following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury. Journal of Neurotrauma. PMID 31595817 DOI: 10.1089/Neu.2019.6570  0.462
2019 Deng-Bryant Y, Leung LY, Madathil S, Flerlage J, Yang F, Yang W, Gilsdorf J, Shear D. Chronic Cognitive Deficits and Associated Histopathology Following Closed-Head Concussive Injury in Rats. Frontiers in Neurology. 10: 699. PMID 31312174 DOI: 10.3389/Fneur.2019.00699  0.385
2019 Pandya JD, Leung LY, Yang X, Flerlage WJ, Gilsdorf JS, Deng-Bryant Y, Shear DA. Comprehensive Profile of Acute Mitochondrial Dysfunction in a Preclinical Model of Severe Penetrating TBI. Frontiers in Neurology. 10: 605. PMID 31244764 DOI: 10.3389/Fneur.2019.00605  0.363
2018 Kassi AAY, Mahavadi AK, Clavijo A, Caliz D, Lee SW, Ahmed AI, Yokobori S, Hu Z, Spurlock MS, Wasserman JM, Rivera KN, Nodal S, Powell HR, Di L, Torres R, ... Leung LY, et al. Enduring Neuroprotective Effect of Subacute Neural Stem Cell Transplantation After Penetrating TBI. Frontiers in Neurology. 9: 1097. PMID 30719019 DOI: 10.3389/Fneur.2018.01097  0.34
2018 Madathil SK, Wilfred BS, Urankar SE, Yang W, Leung LY, Gilsdorf JS, Shear DA. Early Microglial Activation Following Closed-Head Concussive Injury Is Dominated by Pro-Inflammatory M-1 Type. Frontiers in Neurology. 9: 964. PMID 30498469 DOI: 10.3389/Fneur.2018.00964  0.441
2018 Leung LY, Cardiff K, Yang X, Srambical Wilfred B, Gilsdorf J, Shear D. Selective Brain Cooling Reduces Motor Deficits Induced by Combined Traumatic Brain Injury, Hypoxemia and Hemorrhagic Shock. Frontiers in Neurology. 9: 612. PMID 30123177 DOI: 10.3389/Fneur.2018.00612  0.461
2018 Yang Z, Zhu T, Mondello S, Akel M, Wong AT, Kothari IM, Lin F, Shear DA, Gilsdorf J, Leung LY, Bramlett HM, Dixon CE, Dietrich WD, Hayes RL, Povlishock J, et al. Serum-based phospho-neurofilament-heavy protein as theranostic biomarker in three models of traumatic brain injury: an Operation Brain Trauma Therapy (OBTT) study. Journal of Neurotrauma. PMID 29987972 DOI: 10.1089/Neu.2017.5586  0.525
2017 Madathil SK, Deng-Bryant Y, Wilfred BS, Leung LY, Gilsdorf JS, Shear DA. Alterations in brain-derived neurotrophic factor and insulin-like growth factor-1 protein levels after penetrating ballistic-like brain injury in rats. The Journal of Trauma and Acute Care Surgery. 83: S16-S24. PMID 28628600 DOI: 10.1097/Ta.0000000000001471  0.493
2017 Madathil SK, Deng-Bryant Y, Wilfred BS, Leung LY, Gilsdorf JS, Shear DA. Alterations in BDNF and IGF-1 protein levels following penetrating ballistic-like brain injury in rats. The Journal of Trauma and Acute Care Surgery. PMID 28383475 DOI: 10.1097/TA.0000000000001471  0.463
2017 Mountney A, Boutte A, Cartagena CM, Flerlage WJ, Johnson D, Rho C, Lu XM, Yarnell AM, Marcsisin SR, Sousa J, Vuong C, Zottig VE, Leung LY, Deng-Bryant Y, Gilsdorf J, et al. Functional and molecular correlates following single and repeated rat closed-head concussion; indices of vulnerability following brain injury. Journal of Neurotrauma. PMID 28326890 DOI: 10.1089/Neu.2016.4679  0.58
2016 Browning JR, Whiteman AC, Leung LY, Lu XM, Shear DA. Air-puff induced vocalizations: A novel approach to detecting negative affective state following concussion in rats. Journal of Neuroscience Methods. PMID 27984100 DOI: 10.1016/J.Jneumeth.2016.10.017  0.336
2016 Leung LY, Deng-Bryant Y, Cardiff K, Winter M, Tortella F, Shear D. Neurochemical changes following combined hypoxemia and hemorrhagic shock in a rat model of penetrating ballistic-like brain injury: A microdialysis study. The Journal of Trauma and Acute Care Surgery. 81: 860-867. PMID 27769083 DOI: 10.1097/Ta.0000000000001206  0.583
2016 Pandya JD, Sullivan PG, Leung LY, Tortella FC, Shear DA, Deng-Bryant Y. Advanced and High-Throughput Method for Mitochondrial Bioenergetics Evaluation in Neurotrauma. Methods in Molecular Biology (Clifton, N.J.). 1462: 597-610. PMID 27604740 DOI: 10.1007/978-1-4939-3816-2_32  0.37
2016 Deng-Bryant Y, Leung LY, Caudle K, Tortella F, Shear D. Cognitive Evaluation Using Morris Water Maze in Neurotrauma. Methods in Molecular Biology (Clifton, N.J.). 1462: 539-51. PMID 27604737 DOI: 10.1007/978-1-4939-3816-2_29  0.464
2016 Leung LY, Deng-Bryant Y, Shear D, Tortella F. Experimental Models Combining TBI, Hemorrhagic Shock, and Hypoxemia. Methods in Molecular Biology (Clifton, N.J.). 1462: 445-58. PMID 27604733 DOI: 10.1007/978-1-4939-3816-2_25  0.531
2016 Deng-Bryant Y, Readnower R, Leung LY, Tortella F, Shear D. Methods of Drug Delivery in Neurotrauma. Methods in Molecular Biology (Clifton, N.J.). 1462: 89-100. PMID 27604714 DOI: 10.1007/978-1-4939-3816-2_6  0.32
2015 Lu XM, Shear DA, Deng-Bryant Y, Leung LY, Wei G, Chen Z, Tortella FC. Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury. Therapeutic Hypothermia and Temperature Management. PMID 26684246 DOI: 10.1089/Ther.2015.0017  0.573
2015 Leung LY, Deng-Bryant Y, Shear D, Tortella F. Combined hypoxemic and hypotensive insults altered physiological responses and neurofunction in a severity-dependent manner following penetrating ballistic-like brain injury in rats. The Journal of Trauma and Acute Care Surgery. 79: S130-8. PMID 26406425 DOI: 10.1097/Ta.0000000000000785  0.602
2015 Tortella FC, Leung LY. Traumatic Brain Injury and Polytrauma in Theaters of Combat: The Case for Neurotrauma Resuscitation? Shock (Augusta, Ga.). 44: 17-26. PMID 25895144 DOI: 10.1097/Shk.0000000000000380  0.546
2015 Lu XC, Shear DA, Graham PB, Bridson GW, Uttamsingh V, Chen Z, Leung LY, Tortella FC. Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury. Journal of Neurotrauma. PMID 25794265 DOI: 10.1089/Neu.2014.3766  0.425
2015 Gajavelli S, Kentaro S, Diaz J, Yokobori S, Spurlock M, Diaz D, Jackson C, Wick A, Zhao W, Leung LY, Shear D, Tortella F, Bullock MR. Glucose and oxygen metabolism after penetrating ballistic-like brain injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 773-80. PMID 25669903 DOI: 10.1038/Jcbfm.2014.243  0.482
2015 Deng-Bryant Y, Readnower RD, Leung LY, Cunningham TL, Shear DA, Tortella FC. Treatment with amnion-derived cellular cytokine solution (ACCS) induces persistent motor improvement and ameliorates neuroinflammation in a rat model of penetrating ballistic-like brain injury. Restorative Neurology and Neuroscience. 33: 189-203. PMID 25588460 DOI: 10.3233/Rnn-140455  0.522
2014 Leung LY, Larimore Z, Holmes L, Cartagena C, Mountney A, Deng-Bryant Y, Schmid K, Shear D, Tortella F. The WRAIR projectile concussive impact model of mild traumatic brain injury: re-design, testing and preclinical validation. Annals of Biomedical Engineering. 42: 1618-30. PMID 24756867 DOI: 10.1007/S10439-014-1014-8  0.459
2013 Leung LY, Wei G, Shear DA, Tortella FC. The acute effects of hemorrhagic shock on cerebral blood flow, brain tissue oxygen tension, and spreading depolarization following penetrating ballistic-like brain injury. Journal of Neurotrauma. 30: 1288-98. PMID 23461630 DOI: 10.1089/Neu.2012.2715  0.53
2013 Lu XC, Mountney A, Chen Z, Wei G, Cao Y, Leung LY, Khatri V, Cunningham T, Tortella FC. Similarities and differences of acute nonconvulsive seizures and other epileptic activities following penetrating and ischemic brain injuries in rats. Journal of Neurotrauma. 30: 580-90. PMID 23234254 DOI: 10.1089/Neu.2012.2641  0.505
2013 Mountney A, Leung LY, Pedersen R, Shear D, Tortella F. Longitudinal assessment of gait abnormalities following penetrating ballistic-like brain injury in rats. Journal of Neuroscience Methods. 212: 1-16. PMID 22981945 DOI: 10.1016/J.Jneumeth.2012.08.025  0.554
2012 Kane MJ, Angoa-Pérez M, Francescutti DM, Sykes CE, Briggs DI, Leung LY, VandeVord PJ, Kuhn DM. Altered gene expression in cultured microglia in response to simulated blast overpressure: possible role of pulse duration. Neuroscience Letters. 522: 47-51. PMID 22698585 DOI: 10.1016/J.Neulet.2012.06.012  0.49
2012 Chen Z, Leung LY, Mountney A, Liao Z, Yang W, Lu XC, Dave J, Deng-Bryant Y, Wei G, Schmid K, Shear DA, Tortella FC. A novel animal model of closed-head concussive-induced mild traumatic brain injury: development, implementation, and characterization. Journal of Neurotrauma. 29: 268-80. PMID 21988140 DOI: 10.1089/Neu.2011.2057  0.59
2012 Murakami Y, Wei G, Yang X, Lu XC, Leung LY, Shear DA, Tortella FC. Brain oxygen tension monitoring following penetrating ballistic-like brain injury in rats. Journal of Neuroscience Methods. 203: 115-21. PMID 21983109 DOI: 10.1016/J.Jneumeth.2011.09.025  0.558
2008 Leung LY, VandeVord PJ, Dal Cengio AL, Bir C, Yang KH, King AI. Blast related neurotrauma: a review of cellular injury. Molecular & Cellular Biomechanics : McB. 5: 155-68. PMID 18751525  0.601
2008 Vandevord PJ, Leung LY, Hardy W, Mason M, Yang KH, King AI. Up-regulation of reactivity and survival genes in astrocytes after exposure to short duration overpressure. Neuroscience Letters. 434: 247-52. PMID 18342445 DOI: 10.1016/J.Neulet.2008.01.056  0.588
2006 Jin X, Lee JB, Leung LY, Zhang L, Yang KH, King AI. Biomechanical response of the bovine pia-arachnoid complex to tensile loading at varying strain-rates. Stapp Car Crash Journal. 50: 637-49. PMID 17311181 DOI: 10.4271/2006-22-0025  0.532
2006 Leung LY, Tong KY, Zhang SM, Zeng XH, Zhang KP, Zheng XX. Neurochemical effects of exercise and neuromuscular electrical stimulation on brain after stroke: A microdialysis study using rat model Neuroscience Letters. 397: 135-139. PMID 16384643 DOI: 10.1016/J.Neulet.2005.12.006  0.32
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